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EN2 engrailed homeobox 2 [Homo sapiens (human)]

Gene Symbol EN2
Entrez Gene ID 2020
Full Name engrailed homeobox 2
Synonyms
General protein information
Preferred Names
homeobox protein engrailed-2
Names
homeobox protein engrailed-2
hu-En-2
engrailed-2
engrailed homolog 2
homeobox protein en-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q36

Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

131310

Disorder Html: {Autism susceptibility 10}, 611016 (3)





The following EN2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EN2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu17809 NM_001427 Homo sapiens engrailed homeobox 2 (EN2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu17809
Accession Version NM_001427.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1002bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu17809D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein engrailed-2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008060.5 and H16179.1. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2007 this sequence version replaced gi:7710120. Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGAGGAGA ATGACCCCAA GCCTGGCGAA GCAGCGGCGG CGGTGGAGGG ACAGCGGCAG 
CCGGAATCCA GCCCCGGCGG CGGCTCGGGC GGCGGCGGCG GTAGCAGCCC GGGCGAAGCG
GACACCGGGC GCCGGCGGGC TCTGATGCTG CCCGCGGTCC TGCAGGCGCC CGGCAACCAC
CAGCACCCGC ACCGCATCAC CAACTTCTTC ATCGACAACA TCCTGCGGCC CGAGTTCGGC
CGGCGAAAGG ACGCGGGGAC CTGCTGTGCG GGCGCGGGAG GAGGAAGGGG CGGCGGAGCC
GGCGGCGAAG GCGGCGCGAG CGGTGCGGAG GGAGGCGGCG GCGCGGGCGG CTCGGAGCAG
CTCTTGGGCT CGGGCTCCCG AGAGCCCCGG CAGAACCCGC CATGTGCGCC CGGCGCGGGC
GGGCCGCTCC CAGCCGCCGG CAGCGACTCT CCGGGTGACG GGGAAGGCGG CTCCAAGACG
CTCTCGCTGC ACGGTGGCGC CAAGAAAGGC GGCGACCCCG GCGGCCCCCT GGACGGGTCG
CTCAAGGCCC GCGGCTTGGG CGGCGGCGAC CTGTCGGTGA GCTCGGACTC GGACAGCTCG
CAAGCCGGCG CCAACCTGGG CGCGCAGCCC ATGCTCTGGC CGGCGTGGGT CTACTGTACG
CGCTACTCGG ACCGGCCTTC TTCAGGTCCC AGGTCTCGAA AACCAAAGAA GAAGAACCCG
AACAAAGAGG ACAAGCGGCC GCGCACGGCC TTTACCGCCG AGCAGCTGCA GAGGCTCAAG
GCCGAGTTCC AGACCAACAG GTACCTGACG GAGCAGCGGC GCCAGAGCCT GGCGCAGGAG
CTGAGCCTCA ACGAGTCACA GATCAAGATT TGGTTCCAGA ACAAGCGCGC CAAGATCAAG
AAGGCCACGG GCAACAAGAA CACGCTGGCC GTGCACCTCA TGGCACAGGG CTTGTACAAC
CACTCCACCA CAGCCAAGGA GGGCAAGTCG GACAGCGAGT AG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001418.2
CDS250..1251
Misc Feature(1)97..99(+)
Misc Feature(2)976..1155(+)
Misc Feature(3)982..1152(+)
Misc Feature(4)982..1152(+)
Misc Feature(5)988..1140(+)
Misc Feature(6)1075..1077(+)
Misc Feature(7)1153..1248(+)
Exon (1)1..934
Gene:EN2
Gene Synonym:
Exon (2)935..3395
Gene:EN2
Gene Synonym:
Translation
Position Chain Variation Link
25 25 g, t dbSNP:770375144
102 102 c, t dbSNP:371410446
151 151 a, g dbSNP:552094270
178 178 a, g dbSNP:769757719
203 203 c, t dbSNP:762071846
210 210 g, t dbSNP:370541113
211 211 c, t dbSNP:773123908
214 214 -, c dbSNP:762278148
217 217 c, g dbSNP:761281646
218 218 a, g dbSNP:766769570
227 227 a, g dbSNP:754255288
234 234 a, g dbSNP:759889328
275 275 g, t dbSNP:765518301
277 277 c, g dbSNP:193264681
284 284 a, c dbSNP:757950768
285 285 a, g dbSNP:763701034
290 290 c, t dbSNP:751012167
291 291 c, g dbSNP:757278329
324 324 c, t dbSNP:532391062
325 325 a, g dbSNP:745737925
331 331 a, g dbSNP:755989792
335 335 c, t dbSNP:779949325
360 360 a, g dbSNP:77846527
363 363 c, g dbSNP:566174464
368 368 c, t dbSNP:773386776
370 370 g, t dbSNP:747042694
379 379 c, g dbSNP:771494215
384 384 a, g dbSNP:777127172
388 388 c, g dbSNP:536399475
397 397 c, g dbSNP:377588499
411 411 a, g dbSNP:775802810
413 413 a, g dbSNP:762716299
420 420 c, g dbSNP:199573836
421 421 a, g dbSNP:751147295
437 437 c, t dbSNP:756727513
442 442 c, t dbSNP:767081992
476 476 a, g dbSNP:750411626
480 480 c, g dbSNP:756080887
487 487 a, g dbSNP:780033149
498 498 a, g dbSNP:749011148
501 501 c, t dbSNP:758700766
507 507 g, t dbSNP:777849011
510 510 c, t dbSNP:747188277
517 517 a, g dbSNP:771011601
520 520 g, t dbSNP:570191797
521 521 a, g dbSNP:746416611
530 530 a, g dbSNP:770265478
536 536 a, g dbSNP:775981370
543 543 c, t dbSNP:537721922
575 575 a, c dbSNP:764457005
585 585 c, g dbSNP:377426405
602 602 c, t dbSNP:559318676
610 610 c, t dbSNP:3735653
612 612 c, g dbSNP:541045263
626 626 c, t dbSNP:767169856
633 633 a, g dbSNP:375042010
650 650 c, t dbSNP:749919141
653 653 g, t dbSNP:112029171
669 669 a, c dbSNP:760740546
683 683 c, g dbSNP:552755714
688 688 c, g dbSNP:574481432
720 720 a, c dbSNP:535537749
748 748 a, g, t dbSNP:766401663
759 759 c, t dbSNP:754732993
772 772 a, g dbSNP:778710892
785 785 c, g dbSNP:751750999
786 786 c, g dbSNP:757428399
789 789 a, g dbSNP:781300184
790 790 c, t dbSNP:745936826
811 811 g, t dbSNP:770353560
820 820 c, g, t dbSNP:541607705
830 830 a, c, g dbSNP:528546284
831 831 a, c dbSNP:774741741
834 834 a, g dbSNP:761601412
849 849 c, g, t dbSNP:80239010
851 851 a, c dbSNP:760254150
855 855 c, g dbSNP:765844388
870 870 c, t dbSNP:753731945
883 883 c, t dbSNP:759469005
887 887 g, t dbSNP:764971631
891 891 g, t dbSNP:752504232
912 912 c, t dbSNP:757534951
933 933 a, g dbSNP:781388274
937 937 c, t dbSNP:753935837
948 948 a, c dbSNP:755492240
953 953 c, t dbSNP:779467371
955 955 -, aag dbSNP:759522843
960 960 g, t dbSNP:776247308
962 962 a, g dbSNP:748594617
966 966 a, c dbSNP:758843265
967 967 c, g dbSNP:778233183
968 968 c, t dbSNP:746689772
969 969 a, g dbSNP:145749730
976 976 a, g dbSNP:371468430
981 981 c, g dbSNP:776053013
985 985 c, t dbSNP:745380430
986 986 g, t dbSNP:148967146
987 987 g, t dbSNP:144197066
989 989 c, t dbSNP:769119430
990 990 a, g dbSNP:138007513
992 992 a, g dbSNP:762832115
995 995 c, t dbSNP:763911920
996 996 a, g dbSNP:774104222
1005 1005 a, c, t dbSNP:760858656
1006 1006 g, t dbSNP:75103128
1008 1008 c, t dbSNP:753930381
1009 1009 a, g dbSNP:755086292
1011 1011 a, g dbSNP:769434034
1022 1022 a, g dbSNP:753278021
1030 1030 a, g dbSNP:758934130
1032 1032 c, t dbSNP:373725366
1059 1059 a, g dbSNP:112687347
1063 1063 c, g dbSNP:756927720
1067 1067 a, g dbSNP:367902456
1072 1072 c, g dbSNP:745453203
1082 1082 c, t dbSNP:537483172
1083 1083 a, g dbSNP:146535449
1092 1092 c, g dbSNP:775498885
1100 1100 a, g dbSNP:749267229
1101 1101 c, t dbSNP:560776197
1125 1125 c, g dbSNP:141222652
1137 1137 c, t dbSNP:145531356
1141 1141 a, g dbSNP:771694848
1149 1149 a, g dbSNP:34614453
1155 1155 c, t dbSNP:776920563
1157 1157 c, t dbSNP:759624958
1158 1158 a, g dbSNP:148064651
1159 1159 a, g dbSNP:752793394
1161 1161 a, c dbSNP:763601729
1172 1172 a, c, t dbSNP:531423189
1173 1173 a, g dbSNP:140822188
1179 1179 c, g, t dbSNP:56008230
1180 1180 a, g dbSNP:543574732
1181 1181 a, t dbSNP:779590878
1200 1200 c, t dbSNP:748785870
1201 1201 c, t dbSNP:2361689
1203 1203 a, g dbSNP:778824239
1209 1209 a, c, t dbSNP:142774508
1212 1212 c, t dbSNP:772842405
1214 1214 c, g dbSNP:759842570
1215 1215 c, t dbSNP:770116054
1219 1219 a, g dbSNP:775769478
1232 1232 c, g dbSNP:763131813
1236 1236 c, g dbSNP:374787499
1238 1238 c, g, t dbSNP:367924841
1245 1245 c, t dbSNP:149481945
1251 1251 a, c, g dbSNP:773232233
1254 1254 a, c, t dbSNP:12674067
1255 1255 a, g dbSNP:375061145
1256 1256 g, t dbSNP:778233930
1257 1257 c, g dbSNP:748145360
1258 1258 a, g dbSNP:758237125
1263 1263 c, t dbSNP:549356337
1280 1280 a, t dbSNP:777673362
1284 1284 c, t dbSNP:369675027
1285 1285 a, g dbSNP:192274449
1287 1287 c, t dbSNP:775869823
1299 1299 -, t dbSNP:764108512
1310 1310 c, t dbSNP:766755955
1318 1318 g, t dbSNP:184624346
1344 1344 c, t dbSNP:374181653
1375 1375 g, t dbSNP:571482119
1397 1397 g, t dbSNP:539240179
1490 1490 g, t dbSNP:554132267
1504 1504 g, t dbSNP:572702916
1505 1505 c, t dbSNP:754062814
1506 1506 a, g dbSNP:73734533
1633 1633 a, g dbSNP:759986176
1634 1634 c, t dbSNP:189436701
1660 1660 c, t dbSNP:181376144
1670 1670 c, g dbSNP:207468873
1719 1719 g, t dbSNP:775639494
1721 1721 a, g dbSNP:557801689
1731 1731 a, g dbSNP:779579742
1770 1770 c, g dbSNP:185936495
1776 1776 a, g dbSNP:368761266
1792 1792 a, g dbSNP:532304607
1825 1825 c, t dbSNP:372780297
1828 1828 c, g dbSNP:368291486
1845 1845 c, t dbSNP:559329863
1851 1851 -, g dbSNP:144219267
1861 1861 a, g dbSNP:56651365
1867 1867 c, g dbSNP:548222421
1874 1874 g, t dbSNP:143878581
1876 1876 c, t dbSNP:3808330
1896 1896 c, t dbSNP:762442195
1908 1908 c, t dbSNP:531617980
1918 1918 c, t dbSNP:549831481
1955 1955 a, g dbSNP:3808329
1964 1964 c, t dbSNP:189617846
1970 1970 c, t dbSNP:554342116
1971 1971 c, t dbSNP:751121930
1981 1981 c, t dbSNP:3808328
1989 1989 -, cttcctc dbSNP:569397767
1998 1998 g, t dbSNP:536927665
2001 2001 c, t dbSNP:10234087
2008 2008 c, t dbSNP:576070635
2018 2018 a, c dbSNP:537053165
2019 2019 -, cttt dbSNP:111556743
2021 2021 -, ttc dbSNP:769254190
2022 2022 -, tctt dbSNP:371995609
2044 2044 c, t dbSNP:574162792
2050 2050 -, ctt dbSNP:554226119
2060 2060 c, t dbSNP:139789685
2063 2063 c, t dbSNP:745455365
2067 2067 -, ctt dbSNP:574133828
2069 2069 c, t dbSNP:3808327
2075 2075 ct, tc dbSNP:386719925
2075 2075 c, t dbSNP:55729502
2076 2076 c, t dbSNP:3808326
2103 2103 c, t dbSNP:574574146
2114 2114 a, g dbSNP:562841947
2131 2131 a, t dbSNP:57599144
2157 2157 a, g dbSNP:563259530
2159 2159 a, c dbSNP:375798987
2168 2168 a, g dbSNP:531561890
2186 2186 -, c dbSNP:113000817
2188 2188 c, t dbSNP:549768076
2206 2206 c, t dbSNP:370047096
2212 2212 c, t dbSNP:564987207
2217 2217 c, t dbSNP:143914514
2223 2223 g, t dbSNP:768516312
2235 2235 a, g dbSNP:368877872
2244 2244 c, t dbSNP:4716597
2266 2266 c, t dbSNP:181828936
2267 2267 a, g dbSNP:369546982
2322 2322 c, t dbSNP:771068607
2380 2380 g, t dbSNP:114134796
2392 2392 c, t dbSNP:570366558
2418 2418 -, cttc dbSNP:575380918
2444 2444 c, t dbSNP:767302964
2446 2446 a, g, t dbSNP:67027007
2462 2462 a, c dbSNP:558576352
2530 2530 a, g dbSNP:186374442
2549 2549 c, t dbSNP:10949811
2559 2559 -, ac, acac dbSNP:763703116
2560 2560 -, acac dbSNP:144874127
2581 2581 -, cacc dbSNP:767236772
2581 2581 -, a, ac, aca, acaca dbSNP:35869460
2581 2581 a, c dbSNP:77385528
2582 2582 -, aca dbSNP:72022210
2583 2583 -, ac dbSNP:113684257
2584 2584 -, acc dbSNP:762287109
2584 2584 a, c dbSNP:200149777
2623 2623 a, c dbSNP:534694938
2627 2627 g, t dbSNP:552815057
2673 2673 a, c dbSNP:752356970
2689 2689 a, c dbSNP:574540870
2711 2711 c, t dbSNP:190966205
2731 2731 c, t dbSNP:560665142
2733 2733 c, t dbSNP:117213382
2819 2819 a, g dbSNP:545735475
2840 2840 a, c, t dbSNP:549371674
2895 2895 a, g dbSNP:370953015
2911 2911 -, a dbSNP:758514907
2925 2925 c, t dbSNP:182759274
2949 2949 a, g dbSNP:547832038
2967 2967 a, g dbSNP:559599005
2984 2984 c, g dbSNP:753280242
2999 2999 a, g dbSNP:530265860
3044 3044 c, t dbSNP:118079538
3078 3078 -, aaagt dbSNP:762503040
3081 3081 a, c dbSNP:570301953
3099 3099 a, g dbSNP:537790903
3119 3119 a, t dbSNP:780620119
3120 3120 a, c dbSNP:570871717
3124 3124 c, t dbSNP:146402842
3149 3149 c, t dbSNP:552933923
3156 3156 -, c dbSNP:778165644
3156 3156 c, t dbSNP:538621101
3168 3168 a, g dbSNP:573063000
3196 3196 g, t dbSNP:547419446
3222 3222 -, at dbSNP:760202583
3238 3238 -, c dbSNP:34901594
3264 3264 c, t dbSNP:139745969
3276 3276 g, t dbSNP:186998101
3299 3299 c, t dbSNP:115156116
3310 3310 c, t dbSNP:568068965
3318 3318 c, t dbSNP:749917963
3320 3320 c, t dbSNP:373820948
3328 3328 c, t dbSNP:755786194
3329 3329 a, g dbSNP:535221848
3381 3381 c, t dbSNP:56178493

Target ORF information:

RefSeq Version NM_001427
Organism Homo sapiens (human)
Definition Homo sapiens engrailed homeobox 2 (EN2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001427

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGAGGAGA ATGACCCCAA GCCTGGCGAA GCAGCGGCGG CGGTGGAGGG ACAGCGGCAG 
CCGGAATCCA GCCCCGGCGG CGGCTCGGGC GGCGGCGGCG GTAGCAGCCC GGGCGAAGCG
GACACCGGGC GCCGGCGGGC TCTGATGCTG CCCGCGGTCC TGCAGGCGCC CGGCAACCAC
CAGCACCCGC ACCGCATCAC CAACTTCTTC ATCGACAACA TCCTGCGGCC CGAGTTCGGC
CGGCGAAAGG ACGCGGGGAC CTGCTGTGCG GGCGCGGGAG GAGGAAGGGG CGGCGGAGCC
GGCGGCGAAG GCGGCGCGAG CGGTGCGGAG GGAGGCGGCG GCGCGGGCGG CTCGGAGCAG
CTCTTGGGCT CGGGCTCCCG AGAGCCCCGG CAGAACCCGC CATGTGCGCC CGGCGCGGGC
GGGCCGCTCC CAGCCGCCGG CAGCGACTCT CCGGGTGACG GGGAAGGCGG CTCCAAGACG
CTCTCGCTGC ACGGTGGCGC CAAGAAAGGC GGCGACCCCG GCGGCCCCCT GGACGGGTCG
CTCAAGGCCC GCGGCTTGGG CGGCGGCGAC CTGTCGGTGA GCTCGGACTC GGACAGCTCG
CAAGCCGGCG CCAACCTGGG CGCGCAGCCC ATGCTCTGGC CGGCGTGGGT CTACTGTACG
CGCTACTCGG ACCGGCCTTC TTCAGGTCCC AGGTCTCGAA AACCAAAGAA GAAGAACCCG
AACAAAGAGG ACAAGCGGCC GCGCACGGCC TTTACCGCCG AGCAGCTGCA GAGGCTCAAG
GCCGAGTTCC AGACCAACAG GTACCTGACG GAGCAGCGGC GCCAGAGCCT GGCGCAGGAG
CTGAGCCTCA ACGAGTCACA GATCAAGATT TGGTTCCAGA ACAAGCGCGC CAAGATCAAG
AAGGCCACGG GCAACAAGAA CACGCTGGCC GTGCACCTCA TGGCACAGGG CTTGTACAAC
CACTCCACCA CAGCCAAGGA GGGCAAGTCG GACAGCGAGT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.