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EPO cDNA ORF clone, Homo sapiens (human)

Gene Symbol EPO
Entrez Gene ID 2056
Full Name erythropoietin
Synonyms EP, MVCD2
General protein information
Preferred Names
erythropoietin
Names
erythropoietin
epoetin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22

Summary This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

133170

Disorder Html: {Microvascular complications of diabetes 2}, 612623 (3)





The following EPO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20340 NM_000799 Homo sapiens erythropoietin (EPO), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu20340
Accession Version NM_000799.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 582bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product erythropoietin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X02157.1 and S65458.1. This sequence is a reference standard in the RefSeqGene project. On Apr 6, 2005 this sequence version replaced gi:4503588. Summary: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02157.1, BC093628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMEA2159368 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGGGGTGC ACGAATGTCC TGCCTGGCTG TGGCTTCTCC TGTCCCTGCT GTCGCTCCCT 
CTGGGCCTCC CAGTCCTGGG CGCCCCACCA CGCCTCATCT GTGACAGCCG AGTCCTGGAG
AGGTACCTCT TGGAGGCCAA GGAGGCCGAG AATATCACGA CGGGCTGTGC TGAACACTGC
AGCTTGAATG AGAATATCAC TGTCCCAGAC ACCAAAGTTA ATTTCTATGC CTGGAAGAGG
ATGGAGGTCG GGCAGCAGGC CGTAGAAGTC TGGCAGGGCC TGGCCCTGCT GTCGGAAGCT
GTCCTGCGGG GCCAGGCCCT GTTGGTCAAC TCTTCCCAGC CGTGGGAGCC CCTGCAGCTG
CATGTGGATA AAGCCGTCAG TGGCCTTCGC AGCCTCACCA CTCTGCTTCG GGCTCTGGGA
GCCCAGAAGG AAGCCATCTC CCCTCCAGAT GCGGCCTCAG CTGCTCCACT CCGAACAATC
ACTGCTGACA CTTTCCGCAA ACTCTTCCGA GTCTACTCCA ATTTCCTCCG GGGAAAGCTG
AAGCTGTACA CAGGGGAGGC CTGCAGGACA GGGGACAGAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000790.2
CDS182..763
Misc Feature(1)116..118(+)
Misc Feature(2)269..760(+)
Misc Feature(3)281..745(+)
Misc Feature(4)332..334(+)
Misc Feature(5)347..361(+)
Misc Feature(6)374..376(+)
Misc Feature(7)509..511(+)
Misc Feature(8)638..640(+)
Exon (1)1..194
Gene:EPO
Gene Synonym:
Exon (2)195..340
Gene:EPO
Gene Synonym:
Exon (3)341..427
Gene:EPO
Gene Synonym:
Exon (4)428..607
Gene:EPO
Gene Synonym:
Exon (5)608..1330
Gene:EPO
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, g dbSNP:376713532
14 14 c, t dbSNP:761765700
127 127 -, a dbSNP:34144627
127 127 g, t dbSNP:746847015
136 136 a, g dbSNP:756641457
140 140 a, g dbSNP:777893099
142 142 c, t dbSNP:141701177
146 146 a, c, t dbSNP:757521071
152 152 g, t dbSNP:745609348
162 162 a, g dbSNP:771913982
165 165 c, t dbSNP:779789360
170 170 c, t dbSNP:746962384
173 173 g, t dbSNP:768536667
174 174 c, g dbSNP:776523447
187 187 a, g dbSNP:776099080
190 190 a, g dbSNP:759518255
200 200 c, t dbSNP:747612452
218 218 c, t dbSNP:77762674
220 220 c, t dbSNP:541174516
226 226 a, c, t dbSNP:767873303
234 234 c, t dbSNP:770536039
235 235 a, g dbSNP:73409072
237 237 g, t dbSNP:760976625
257 257 c, g, t dbSNP:764644750
262 262 c, t dbSNP:750729016
268 268 a, c dbSNP:761916506
271 271 a, c dbSNP:765404850
272 272 c, t dbSNP:750589543
289 289 c, t dbSNP:140045752
291 291 a, g dbSNP:766552442
293 293 a, g dbSNP:200020971
302 302 a, c dbSNP:780420565
311 311 c, t dbSNP:754755075
326 326 g, t dbSNP:781053357
327 327 c, t dbSNP:748086642
328 328 c, g, t dbSNP:149877548
329 329 a, g dbSNP:748786072
335 335 a, t dbSNP:770575141
339 339 c, t dbSNP:773895305
340 340 c, g dbSNP:747340501
342 342 c, t dbSNP:201069425
344 344 c, g dbSNP:778559798
352 352 c, t dbSNP:61735970
356 356 c, t dbSNP:369033773
370 370 c, t dbSNP:781673396
382 382 c, t dbSNP:748564118
389 389 a, g dbSNP:62483572
396 396 a, g dbSNP:570715685
409 409 -, t dbSNP:34937405
409 409 g, t dbSNP:763035217
418 418 a, g dbSNP:57694744
422 422 a, g dbSNP:774561885
430 430 c, t dbSNP:749758292
431 431 a, c, g dbSNP:137953994
433 433 a, g dbSNP:759640016
442 442 c, t dbSNP:140683829
443 443 g, t dbSNP:370493713
450 450 c, t dbSNP:760394172
452 452 -, g dbSNP:71517124
464 464 a, g dbSNP:763792025
465 465 a, c dbSNP:776547281
467 467 c, g dbSNP:761633990
474 474 c, t dbSNP:765261245
475 475 a, g dbSNP:374875798
481 481 c, t dbSNP:758007491
488 488 c, t dbSNP:367645892
490 490 c, g dbSNP:751264643
491 491 a, g dbSNP:754729905
492 492 a, g, t dbSNP:777990553
497 497 a, g dbSNP:757662591
498 498 a, c dbSNP:779493836
505 505 a, g dbSNP:745887893
506 506 a, g dbSNP:772142028
517 517 c, t dbSNP:569327723
519 519 a, c dbSNP:775612706
522 522 c, t dbSNP:11976235
523 523 a, g dbSNP:768971818
529 529 a, g dbSNP:776259969
533 533 c, t dbSNP:761700728
540 540 c, t dbSNP:551748179
548 548 c, g dbSNP:773297902
552 552 a, g dbSNP:762488723
556 556 c, t dbSNP:566780061
557 557 a, g dbSNP:372093552
564 564 c, g dbSNP:746684403
570 570 a, g dbSNP:200241729
573 573 c, g dbSNP:376551627
580 580 c, t dbSNP:754099124
590 590 c, t dbSNP:369003114
591 591 a, g dbSNP:376745626
592 592 a, g dbSNP:746367858
599 599 c, g dbSNP:1126887
602 602 c, g dbSNP:758961204
611 611 a, g dbSNP:201051019
617 617 a, c dbSNP:780560676
619 619 c, t dbSNP:751552242
620 620 c, t dbSNP:755088347
621 621 c, g dbSNP:149431976
624 624 c, t dbSNP:748386526
625 625 g, t dbSNP:375550656
629 629 c, g dbSNP:770204024
633 633 a, c, t dbSNP:370232752
634 634 a, g dbSNP:78925197
640 640 a, g dbSNP:774438389
641 641 a, c, g dbSNP:758914998
648 648 c, t dbSNP:373734290
650 650 c, g dbSNP:760345451
652 652 c, t dbSNP:763785260
654 654 a, g dbSNP:750737268
664 664 c, t dbSNP:763338387
668 668 c, g dbSNP:201326665
673 673 g, t dbSNP:752118071
677 677 c, t dbSNP:73409075
678 678 a, g dbSNP:781324278
689 689 c, t dbSNP:752755372
690 690 a, g dbSNP:756377367
702 702 a, g dbSNP:778175956
721 721 a, g dbSNP:749028009
728 728 c, t dbSNP:757134843
732 732 c, t dbSNP:778634537
733 733 a, c, g dbSNP:144031260
740 740 g, t dbSNP:368744075
747 747 a, g dbSNP:746545386
750 750 c, t dbSNP:768257400
754 754 a, g dbSNP:776269617
755 755 a, g dbSNP:763243146
756 756 a, g dbSNP:750759945
757 757 c, g, t dbSNP:530329727
758 758 -, a dbSNP:369859204
758 758 a, g dbSNP:371108812
766 766 a, g dbSNP:760053342
767 767 g, t dbSNP:767954284
768 768 a, g dbSNP:375035296
779 779 c, t dbSNP:756270854
781 781 a, g dbSNP:764356536
786 786 a, c, t dbSNP:754101715
788 788 c, g dbSNP:778739489
789 789 a, c dbSNP:745700208
793 793 a, g dbSNP:189775061
794 794 c, t dbSNP:563121954
801 801 c, t dbSNP:746449281
802 802 a, g dbSNP:768167384
809 809 c, t dbSNP:200436414
811 811 a, g dbSNP:747791938
814 814 g, t dbSNP:769368895
826 826 c, t dbSNP:202242218
832 832 a, g dbSNP:551617369
856 856 g, t dbSNP:141911577
869 869 c, t dbSNP:192883541
906 906 a, g dbSNP:150610526
942 942 a, g dbSNP:184441242
983 983 c, g dbSNP:535398997
1018 1018 c, g dbSNP:769281334
1019 1019 a, c dbSNP:550360369
1030 1030 c, g dbSNP:78182250
1098 1098 c, t dbSNP:77450727
1113 1113 c, t dbSNP:771751685
1114 1114 g, t dbSNP:188830852
1145 1145 g, t dbSNP:564449
1182 1182 c, t dbSNP:533509296
1183 1183 a, g dbSNP:564197288
1193 1193 a, c dbSNP:574378882
1225 1225 a, g dbSNP:114461287
1257 1257 c, g dbSNP:563055654
1318 1318 c, g dbSNP:578191720
1323 1323 a, c dbSNP:545605665
1326 1326 a, t dbSNP:560335826

Target ORF information:

RefSeq Version NM_000799
Organism Homo sapiens (human)
Definition Homo sapiens erythropoietin (EPO), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000799

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGGGTGC ACGAATGTCC TGCCTGGCTG TGGCTTCTCC TGTCCCTGCT GTCGCTCCCT 
CTGGGCCTCC CAGTCCTGGG CGCCCCACCA CGCCTCATCT GTGACAGCCG AGTCCTGGAG
AGGTACCTCT TGGAGGCCAA GGAGGCCGAG AATATCACGA CGGGCTGTGC TGAACACTGC
AGCTTGAATG AGAATATCAC TGTCCCAGAC ACCAAAGTTA ATTTCTATGC CTGGAAGAGG
ATGGAGGTCG GGCAGCAGGC CGTAGAAGTC TGGCAGGGCC TGGCCCTGCT GTCGGAAGCT
GTCCTGCGGG GCCAGGCCCT GTTGGTCAAC TCTTCCCAGC CGTGGGAGCC CCTGCAGCTG
CATGTGGATA AAGCCGTCAG TGGCCTTCGC AGCCTCACCA CTCTGCTTCG GGCTCTGGGA
GCCCAGAAGG AAGCCATCTC CCCTCCAGAT GCGGCCTCAG CTGCTCCACT CCGAACAATC
ACTGCTGACA CTTTCCGCAA ACTCTTCCGA GTCTACTCCA ATTTCCTCCG GGGAAAGCTG
AAGCTGTACA CAGGGGAGGC CTGCAGGACA GGGGACAGAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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