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EPOR cDNA ORF clone, Homo sapiens (human)

Gene Symbol EPOR
Entrez Gene ID 2057
Full Name erythropoietin receptor
Synonyms EPO-R
General protein information
Preferred Names
erythropoietin receptor
Names
erythropoietin receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.3-p13.2

Summary This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. lac of sum
Disorder MIM:

133171

Disorder Html: [Erythrocytosis, familial], 133100 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000121 NP_000112 erythropoietin receptor precursor



Homo sapiens (human) EPOR NP_000112.1
Pan troglodytes (chimpanzee) EPOR XP_003953409.1
Macaca mulatta (Rhesus monkey) EPOR XP_001105833.1
Canis lupus familiaris (dog) EPOR NP_001041576.1
Bos taurus (cattle) EPOR NP_001192530.1
Mus musculus (house mouse) Epor NP_034279.3
Rattus norvegicus (Norway rat) Epor NP_058698.2
Danio rerio (zebrafish) epor NP_001036799.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following EPOR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPOR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23230
NM_000121 Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23230
Clone ID Related Accession (Same CDS sequence) NM_000121
Accession Version NM_000121.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1527bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product erythropoietin receptor precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC019092.2, M60459.1, AC024575.6 and BU619338.1. This sequence is a reference standard in the RefSeqGene project. On May 14, 2010 this sequence version replaced gi:4557561. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60459.1, BC112153.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGACCACC TCGGGGCGTC CCTCTGGCCC CAGGTCGGCT CCCTTTGTCT CCTGCTCGCT 
GGGGCCGCCT GGGCGCCCCC GCCTAACCTC CCGGACCCCA AGTTCGAGAG CAAAGCGGCC
TTGCTGGCGG CCCGGGGGCC CGAAGAGCTT CTGTGCTTCA CCGAGCGGTT GGAGGACTTG
GTGTGTTTCT GGGAGGAAGC GGCGAGCGCT GGGGTGGGCC CGGGCAACTA CAGCTTCTCC
TACCAGCTCG AGGATGAGCC ATGGAAGCTG TGTCGCCTGC ACCAGGCTCC CACGGCTCGT
GGTGCGGTGC GCTTCTGGTG TTCGCTGCCT ACAGCCGACA CGTCGAGCTT CGTGCCCCTA
GAGTTGCGCG TCACAGCAGC CTCCGGCGCT CCGCGATATC ACCGTGTCAT CCACATCAAT
GAAGTAGTGC TCCTAGACGC CCCCGTGGGG CTGGTGGCGC GGTTGGCTGA CGAGAGCGGC
CACGTAGTGT TGCGCTGGCT CCCGCCGCCT GAGACACCCA TGACGTCTCA CATCCGCTAC
GAGGTGGACG TCTCGGCCGG CAACGGCGCA GGGAGCGTAC AGAGGGTGGA GATCCTGGAG
GGCCGCACCG AGTGTGTGCT GAGCAACCTG CGGGGCCGGA CGCGCTACAC CTTCGCCGTC
CGCGCGCGTA TGGCTGAGCC GAGCTTCGGC GGCTTCTGGA GCGCCTGGTC GGAGCCTGTG
TCGCTGCTGA CGCCTAGCGA CCTGGACCCC CTCATCCTGA CGCTCTCCCT CATCCTCGTG
GTCATCCTGG TGCTGCTGAC CGTGCTCGCG CTGCTCTCCC ACCGCCGGGC TCTGAAGCAG
AAGATCTGGC CTGGCATCCC GAGCCCAGAG AGCGAGTTTG AAGGCCTCTT CACCACCCAC
AAGGGTAACT TCCAGCTGTG GCTGTACCAG AATGATGGCT GCCTGTGGTG GAGCCCCTGC
ACCCCCTTCA CGGAGGACCC ACCTGCTTCC CTGGAAGTCC TCTCAGAGCG CTGCTGGGGG
ACGATGCAGG CAGTGGAGCC GGGGACAGAT GATGAGGGCC CCCTGCTGGA GCCAGTGGGC
AGTGAGCATG CCCAGGATAC CTATCTGGTG CTGGACAAAT GGTTGCTGCC CCGGAACCCG
CCCAGTGAGG ACCTCCCAGG GCCTGGTGGC AGTGTGGACA TAGTGGCCAT GGATGAAGGC
TCAGAAGCAT CCTCCTGCTC ATCTGCTTTG GCCTCGAAGC CCAGCCCAGA GGGAGCCTCT
GCTGCCAGCT TTGAGTACAC TATCCTGGAC CCCAGCTCCC AGCTCTTGCG TCCATGGACA
CTGTGCCCTG AGCTGCCCCC TACCCCACCC CACCTAAAGT ACCTGTACCT TGTGGTATCT
GACTCTGGCA TCTCAACTGA CTACAGCTCA GGGGACTCCC AGGGAGCCCA AGGGGGCTTA
TCCGATGGCC CCTACTCCAA CCCTTATGAG AACAGCCTTA TCCCAGCCGC TGAGCCTCTG
CCCCCCAGCT ATGTGGCTTG CTCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000112.1
CDS136..1662
Misc Feature(1)58..60(+)
Misc Feature(2)244..555(+)
Misc Feature(3)484..486(+)
Misc Feature(4)571..867(+)
Misc Feature(5)769..831(+)
Misc Feature(6)832..846(+)
Misc Feature(7)832..846(+)
Misc Feature(8)886..954(+)
Misc Feature(9)979..1005(+)
Misc Feature(10)1237..1239(+)
Misc Feature(11)1237..1239(+)
Misc Feature(12)1411..1413(+)
Misc Feature(13)1411..1413(+)
Misc Feature(14)1489..1506(+)
Misc Feature(15)1495..1503(+)
Misc Feature(16)1495..1497(+)
Misc Feature(17)1495..1497(+)
Misc Feature(18)1501..1503(+)
Misc Feature(19)1501..1503(+)
Misc Feature(20)1537..1539(+)
Misc Feature(21)1588..1590(+)
Misc Feature(22)1588..1590(+)
Misc Feature(23)1600..1602(+)
Misc Feature(24)1645..1647(+)
Exon (1)1..250
Gene:EPOR
Gene Synonym:
Exon (2)251..386
Gene:EPOR
Gene Synonym:
Exon (3)387..562
Gene:EPOR
Gene Synonym:
Exon (4)563..720
Gene:EPOR
Gene Synonym:
Exon (5)721..874
Gene:EPOR
Gene Synonym:
Exon (6)875..962
Gene:EPOR
Gene Synonym:
Exon (7)963..1050
Gene:EPOR
Gene Synonym:
Exon (8)1051..2441
Gene:EPOR
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000121
Organism Homo sapiens (human)
Definition Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000121

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGACCACC TCGGGGCGTC CCTCTGGCCC CAGGTCGGCT CCCTTTGTCT CCTGCTCGCT 
GGGGCCGCCT GGGCGCCCCC GCCTAACCTC CCGGACCCCA AGTTCGAGAG CAAAGCGGCC
TTGCTGGCGG CCCGGGGGCC CGAAGAGCTT CTGTGCTTCA CCGAGCGGTT GGAGGACTTG
GTGTGTTTCT GGGAGGAAGC GGCGAGCGCT GGGGTGGGCC CGGGCAACTA CAGCTTCTCC
TACCAGCTCG AGGATGAGCC ATGGAAGCTG TGTCGCCTGC ACCAGGCTCC CACGGCTCGT
GGTGCGGTGC GCTTCTGGTG TTCGCTGCCT ACAGCCGACA CGTCGAGCTT CGTGCCCCTA
GAGTTGCGCG TCACAGCAGC CTCCGGCGCT CCGCGATATC ACCGTGTCAT CCACATCAAT
GAAGTAGTGC TCCTAGACGC CCCCGTGGGG CTGGTGGCGC GGTTGGCTGA CGAGAGCGGC
CACGTAGTGT TGCGCTGGCT CCCGCCGCCT GAGACACCCA TGACGTCTCA CATCCGCTAC
GAGGTGGACG TCTCGGCCGG CAACGGCGCA GGGAGCGTAC AGAGGGTGGA GATCCTGGAG
GGCCGCACCG AGTGTGTGCT GAGCAACCTG CGGGGCCGGA CGCGCTACAC CTTCGCCGTC
CGCGCGCGTA TGGCTGAGCC GAGCTTCGGC GGCTTCTGGA GCGCCTGGTC GGAGCCTGTG
TCGCTGCTGA CGCCTAGCGA CCTGGACCCC CTCATCCTGA CGCTCTCCCT CATCCTCGTG
GTCATCCTGG TGCTGCTGAC CGTGCTCGCG CTGCTCTCCC ACCGCCGGGC TCTGAAGCAG
AAGATCTGGC CTGGCATCCC GAGCCCAGAG AGCGAGTTTG AAGGCCTCTT CACCACCCAC
AAGGGTAACT TCCAGCTGTG GCTGTACCAG AATGATGGCT GCCTGTGGTG GAGCCCCTGC
ACCCCCTTCA CGGAGGACCC ACCTGCTTCC CTGGAAGTCC TCTCAGAGCG CTGCTGGGGG
ACGATGCAGG CAGTGGAGCC GGGGACAGAT GATGAGGGCC CCCTGCTGGA GCCAGTGGGC
AGTGAGCATG CCCAGGATAC CTATCTGGTG CTGGACAAAT GGTTGCTGCC CCGGAACCCG
CCCAGTGAGG ACCTCCCAGG GCCTGGTGGC AGTGTGGACA TAGTGGCCAT GGATGAAGGC
TCAGAAGCAT CCTCCTGCTC ATCTGCTTTG GCCTCGAAGC CCAGCCCAGA GGGAGCCTCT
GCTGCCAGCT TTGAGTACAC TATCCTGGAC CCCAGCTCCC AGCTCTTGCG TCCATGGACA
CTGTGCCCTG AGCTGCCCCC TACCCCACCC CACCTAAAGT ACCTGTACCT TGTGGTATCT
GACTCTGGCA TCTCAACTGA CTACAGCTCA GGGGACTCCC AGGGAGCCCA AGGGGGCTTA
TCCGATGGCC CCTACTCCAA CCCTTATGAG AACAGCCTTA TCCCAGCCGC TGAGCCTCTG
CCCCCCAGCT ATGTGGCTTG CTCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation
Biochem. Biophys. Res. Commun. 445 (1), 163-169 (2014)
Reinbothe S, Larsson AM, Vaapil M, Wigerup C, Sun J, Jogi A, Neumann D, Ronnstrand L and Pahlman S.


book

In vivo knockdown of adipocyte erythropoietin receptor does not alter glucose or energy homeostasis
Endocrinology 154 (10), 3652-3659 (2013)
Luk CT, Shi SY, Choi D, Cai EP, Schroer SA and Woo M.


book

Erythropoietin is involved in the angiogenic potential of bone marrow macrophages in multiple myeloma
Angiogenesis 16 (4), 963-973 (2013)
De Luisi A, Binetti L, Ria R, Ruggieri S, Berardi S, Catacchio I, Racanelli V, Pavone V, Rossini B, Vacca A and Ribatti D.


book

Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes
PLoS ONE 8 (4), E60326 (2013)
Lisowska KA, Frackowiak JE, Mikosik A and Witkowski JM.


book

A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells
Science 257 (5073), 1138-1141 (1992)
Nakamura Y, Komatsu N and Nakauchi H.


book

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130
Mol. Cell. Biol. 12 (2), 706-715 (1992)
Yoshimura A and Lodish HF.


book

Genomic organization of the human erythropoietin receptor gene
Genomics 11 (4), 974-980 (1991)
Penny LA and Forget BG.


book

Cloning of the gene encoding the human erythropoietin receptor
Blood 78 (10), 2557-2563 (1991)
Maouche L, Tournamille C, Hattab C, Boffa G, Cartron JP and Chretien S.


book

The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1
Exp. Hematol. 19 (9), 973-977 (1991)
Ehrenman K and St John T.


book

Human erythropoietin receptor: cloning, expression, and biologic characterization
Blood 76 (1), 31-35 (1990)
Jones SS, D'Andrea AD, Haines LL and Wong GG.


 
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