The following EPOR gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPOR gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1527bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||erythropoietin receptor precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC019092.2, M60459.1,
AC024575.6 and BU619338.1.
This sequence is a reference standard in the RefSeqGene project.
On May 14, 2010 this sequence version replaced gi:4557561.
Summary: This gene encodes the erythropoietin receptor which is a
member of the cytokine receptor family. Upon erythropoietin
binding, this receptor activates Jak2 tyrosine kinase which
activates different intracellular pathways including: Ras/MAP
kinase, phosphatidylinositol 3-kinase and STAT transcription
factors. The stimulated erythropoietin receptor appears to have a
role in erythroid cell survival. Defects in the erythropoietin
receptor may produce erythroleukemia and familial erythrocytosis.
Dysregulation of this gene may affect the growth of certain tumors.
Alternate splicing results in multiple transcript
variants.[provided by RefSeq, May 2010].
Transcript Variant: This variant (1) encodes the functional
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: M60459.1, BC112153.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 5' end.