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ERBB3 erb-b2 receptor tyrosine kinase 3 [Homo sapiens (human)]

Gene Symbol ERBB3
Entrez Gene ID 2065
Full Name erb-b2 receptor tyrosine kinase 3
Synonyms ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
General protein information
Preferred Names
receptor tyrosine-protein kinase erbB-3
Names
receptor tyrosine-protein kinase erbB-3
proto-oncogene-like protein c-ErbB-3
tyrosine kinase-type cell surface receptor HER3
NP_001005915.1
NP_001973.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

190151

Disorder Html: Lethal congenital contractural syndrome 2, 607598 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu27015 NM_001982 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock 16 Starting from $99.00
OHu20847 NM_001005915 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant s, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu27015D
Sequence Information ORF Nucleotide Sequence (Length: 4029bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-3 isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC344156.1, DC347955.1, BC082992.1, BU674508.1 and AA524528.1. This sequence is a reference standard in the RefSeqGene project. On Jan 7, 2011 this sequence version replaced gi:54792099. Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M34309.1, BC082992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
ATGAGGGCGA ACGACGCTCT GCAGGTGCTG GGCTTGCTTT TCAGCCTGGC CCGGGGCTCC 
GAGGTGGGCA ACTCTCAGGC AGTGTGTCCT GGGACTCTGA ATGGCCTGAG TGTGACCGGC
GATGCTGAGA ACCAATACCA GACACTGTAC AAGCTCTACG AGAGGTGTGA GGTGGTGATG
GGGAACCTTG AGATTGTGCT CACGGGACAC AATGCCGACC TCTCCTTCCT GCAGTGGATT
CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAATGAAT TCTCTACTCT ACCATTGCCC
AACCTCCGCG TGGTGCGAGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTCGTCATG
TTGAACTATA ACACCAACTC CAGCCACGCT CTGCGCCAGC TCCGCTTGAC TCAGCTCACC
GAGATTCTGT CAGGGGGTGT TTATATTGAG AAGAACGATA AGCTTTGTCA CATGGACACA
ATTGACTGGA GGGACATCGT GAGGGACCGA GATGCTGAGA TAGTGGTGAA GGACAATGGC
AGAAGCTGTC CCCCCTGTCA TGAGGTTTGC AAGGGGCGAT GCTGGGGTCC TGGATCAGAA
GACTGCCAGA CATTGACCAA GACCATCTGT GCTCCTCAGT GTAATGGTCA CTGCTTTGGG
CCCAACCCCA ACCAGTGCTG CCATGATGAG TGTGCCGGGG GCTGCTCAGG CCCTCAGGAC
ACAGACTGCT TTGCCTGCCG GCACTTCAAT GACAGTGGAG CCTGTGTACC TCGCTGTCCA
CAGCCTCTTG TCTACAACAA GCTAACTTTC CAGCTGGAAC CCAATCCCCA CACCAAGTAT
CAGTATGGAG GAGTTTGTGT AGCCAGCTGT CCCCATAACT TTGTGGTGGA TCAAACATCC
TGTGTCAGGG CCTGTCCTCC TGACAAGATG GAAGTAGATA AAAATGGGCT CAAGATGTGT
GAGCCTTGTG GGGGACTATG TCCCAAAGCC TGTGAGGGAA CAGGCTCTGG GAGCCGCTTC
CAGACTGTGG ACTCGAGCAA CATTGATGGA TTTGTGAACT GCACCAAGAT CCTGGGCAAC
CTGGACTTTC TGATCACCGG CCTCAATGGA GACCCCTGGC ACAAGATCCC TGCCCTGGAC
CCAGAGAAGC TCAATGTCTT CCGGACAGTA CGGGAGATCA CAGGTTACCT GAACATCCAG
TCCTGGCCGC CCCACATGCA CAACTTCAGT GTTTTTTCCA ATTTGACAAC CATTGGAGGC
AGAAGCCTCT ACAACCGGGG CTTCTCATTG TTGATCATGA AGAACTTGAA TGTCACATCT
CTGGGCTTCC GATCCCTGAA GGAAATTAGT GCTGGGCGTA TCTATATAAG TGCCAATAGG
CAGCTCTGCT ACCACCACTC TTTGAACTGG ACCAAGGTGC TTCGGGGGCC TACGGAAGAG
CGACTAGACA TCAAGCATAA TCGGCCGCGC AGAGACTGCG TGGCAGAGGG CAAAGTGTGT
GACCCACTGT GCTCCTCTGG GGGATGCTGG GGCCCAGGCC CTGGTCAGTG CTTGTCCTGT
CGAAATTATA GCCGAGGAGG TGTCTGTGTG ACCCACTGCA ACTTTCTGAA TGGGGAGCCT
CGAGAATTTG CCCATGAGGC CGAATGCTTC TCCTGCCACC CGGAATGCCA ACCCATGGAG
GGCACTGCCA CATGCAATGG CTCGGGCTCT GATACTTGTG CTCAATGTGC CCATTTTCGA
GATGGGCCCC ACTGTGTGAG CAGCTGCCCC CATGGAGTCC TAGGTGCCAA GGGCCCAATC
TACAAGTACC CAGATGTTCA GAATGAATGT CGGCCCTGCC ATGAGAACTG CACCCAGGGG
TGTAAAGGAC CAGAGCTTCA AGACTGTTTA GGACAAACAC TGGTGCTGAT CGGCAAAACC
CATCTGACAA TGGCTTTGAC AGTGATAGCA GGATTGGTAG TGATTTTCAT GATGCTGGGC
GGCACTTTTC TCTACTGGCG TGGGCGCCGG ATTCAGAATA AAAGGGCTAT GAGGCGATAC
TTGGAACGGG GTGAGAGCAT AGAGCCTCTG GACCCCAGTG AGAAGGCTAA CAAAGTCTTG
GCCAGAATCT TCAAAGAGAC AGAGCTAAGG AAGCTTAAAG TGCTTGGCTC GGGTGTCTTT
GGAACTGTGC ACAAAGGAGT GTGGATCCCT GAGGGTGAAT CAATCAAGAT TCCAGTCTGC
ATTAAAGTCA TTGAGGACAA GAGTGGACGG CAGAGTTTTC AAGCTGTGAC AGATCATATG
CTGGCCATTG GCAGCCTGGA CCATGCCCAC ATTGTAAGGC TGCTGGGACT ATGCCCAGGG
TCATCTCTGC AGCTTGTCAC TCAATATTTG CCTCTGGGTT CTCTGCTGGA TCATGTGAGA
CAACACCGGG GGGCACTGGG GCCACAGCTG CTGCTCAACT GGGGAGTACA AATTGCCAAG
GGAATGTACT ACCTTGAGGA ACATGGTATG GTGCATAGAA ACCTGGCTGC CCGAAACGTG
CTACTCAAGT CACCCAGTCA GGTTCAGGTG GCAGATTTTG GTGTGGCTGA CCTGCTGCCT
CCTGATGATA AGCAGCTGCT ATACAGTGAG GCCAAGACTC CAATTAAGTG GATGGCCCTT
GAGAGTATCC ACTTTGGGAA ATACACACAC CAGAGTGATG TCTGGAGCTA TGGTGTGACA
GTTTGGGAGT TGATGACCTT CGGGGCAGAG CCCTATGCAG GGCTACGATT GGCTGAAGTA
CCAGACCTGC TAGAGAAGGG GGAGCGGTTG GCACAGCCCC AGATCTGCAC AATTGATGTC
TACATGGTGA TGGTCAAGTG TTGGATGATT GATGAGAACA TTCGCCCAAC CTTTAAAGAA
CTAGCCAATG AGTTCACCAG GATGGCCCGA GACCCACCAC GGTATCTGGT CATAAAGAGA
GAGAGTGGGC CTGGAATAGC CCCTGGGCCA GAGCCCCATG GTCTGACAAA CAAGAAGCTA
GAGGAAGTAG AGCTGGAGCC AGAACTAGAC CTAGACCTAG ACTTGGAAGC AGAGGAGGAC
AACCTGGCAA CCACCACACT GGGCTCCGCC CTCAGCCTAC CAGTTGGAAC ACTTAATCGG
CCACGTGGGA GCCAGAGCCT TTTAAGTCCA TCATCTGGAT ACATGCCCAT GAACCAGGGT
AATCTTGGGG AGTCTTGCCA GGAGTCTGCA GTTTCTGGGA GCAGTGAACG GTGCCCCCGT
CCAGTCTCTC TACACCCAAT GCCACGGGGA TGCCTGGCAT CAGAGTCATC AGAGGGGCAT
GTAACAGGCT CTGAGGCTGA GCTCCAGGAG AAAGTGTCAA TGTGTAGGAG CCGGAGCAGG
AGCCGGAGCC CACGGCCACG CGGAGATAGC GCCTACCATT CCCAGCGCCA CAGTCTGCTG
ACTCCTGTTA CCCCACTCTC CCCACCCGGG TTAGAGGAAG AGGATGTCAA CGGTTATGTC
ATGCCAGATA CACACCTCAA AGGTACTCCC TCCTCCCGGG AAGGCACCCT TTCTTCAGTG
GGTCTCAGTT CTGTCCTGGG TACTGAAGAA GAAGATGAAG ATGAGGAGTA TGAATACATG
AACCGGAGGA GAAGGCACAG TCCACCTCAT CCCCCTAGGC CAAGTTCCCT TGAGGAGCTG
GGTTATGAGT ACATGGATGT GGGGTCAGAC CTCAGTGCCT CTCTGGGCAG CACACAGAGT
TGCCCACTCC ACCCTGTACC CATCATGCCC ACTGCAGGCA CAACTCCAGA TGAAGACTAT
GAATATATGA ATCGGCAACG AGATGGAGGT GGTCCTGGGG GTGATTATGC AGCCATGGGG
GCCTGCCCAG CATCTGAGCA AGGGTATGAA GAGATGAGAG CTTTTCAGGG GCCTGGACAT
CAGGCCCCCC ATGTCCATTA TGCCCGCCTA AAAACTCTAC GTAGCTTAGA GGCTACAGAC
TCTGCCTTTG ATAACCCTGA TTACTGGCAT AGCAGGCTTT TCCCCAAGGC TAATGCCCAG
AGAACGTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001973.2
CDS277..4305
Misc Feature(1)220..222(+)
Misc Feature(2)442..777(+)
Misc Feature(3)811..1272(+)
Misc Feature(4)814..921(+)
Misc Feature(5)952..1074(+)
Misc Feature(6)1333..1698(+)
Misc Feature(7)1771..2166(+)
Misc Feature(8)1774..1935(+)
Misc Feature(9)1930..>2052(+)
Misc Feature(10)2188..2304(+)
Misc Feature(11)2197..2277(+)
Misc Feature(12)2206..2268(+)
Misc Feature(13)2377..3213(+)
Misc Feature(14)2401..3171(+)
Misc Feature(15)2419..2832(+)
Misc Feature(16)2893..2895(+)
Misc Feature(17)3436..3438(+)
Misc Feature(18)3643..3645(+)
Misc Feature(19)3865..3867(+)
Misc Feature(20)3871..3873(+)
Misc Feature(21)3940..3942(+)
Misc Feature(22)4054..4056(+)
Misc Feature(23)4060..4062(+)
Misc Feature(24)4102..4104(+)
Misc Feature(25)4141..4143(+)
Misc Feature(26)4258..4260(+)
Exon (1)1..358
Gene:ERBB3
Gene Synonym:
Exon (2)359..510
Gene:ERBB3
Gene Synonym:
Exon (3)511..697
Gene:ERBB3
Gene Synonym:
Exon (4)698..823
Gene:ERBB3
Gene Synonym:
Exon (5)824..889
Gene:ERBB3
Gene Synonym:
Exon (6)890..1008
Gene:ERBB3
Gene Synonym:
Exon (7)1009..1150
Gene:ERBB3
Gene Synonym:
Exon (8)1151..1264
Gene:ERBB3
Gene Synonym:
Exon (9)1265..1385
Gene:ERBB3
Gene Synonym:
Exon (10)1386..1459
Gene:ERBB3
Gene Synonym:
Exon (11)1460..1550
Gene:ERBB3
Gene Synonym:
Exon (12)1551..1756
Gene:ERBB3
Gene Synonym:
Exon (13)1757..1889
Gene:ERBB3
Gene Synonym:
Exon (14)1890..1980
Gene:ERBB3
Gene Synonym:
Exon (15)1981..2135
Gene:ERBB3
Gene Synonym:
Exon (16)2136..2189
Gene:ERBB3
Gene Synonym:
Exon (17)2190..2331
Gene:ERBB3
Gene Synonym:
Exon (18)2332..2451
Gene:ERBB3
Gene Synonym:
Exon (19)2452..2550
Gene:ERBB3
Gene Synonym:
Exon (20)2551..2736
Gene:ERBB3
Gene Synonym:
Exon (21)2737..2892
Gene:ERBB3
Gene Synonym:
Exon (22)2893..2968
Gene:ERBB3
Gene Synonym:
Exon (23)2969..3115
Gene:ERBB3
Gene Synonym:
Exon (24)3116..3213
Gene:ERBB3
Gene Synonym:
Exon (25)3214..3405
Gene:ERBB3
Gene Synonym:
Exon (26)3406..3477
Gene:ERBB3
Gene Synonym:
Exon (27)3478..3778
Gene:ERBB3
Gene Synonym:
Exon (28)3779..5757
Gene:ERBB3
Gene Synonym:
Translation
Position Chain Variation Link
20 20 a, g dbSNP:527525537
43 43 c, g dbSNP:542546359
57 57 c, t dbSNP:560882038
66 66 -, ctct, ttct dbSNP:374077612
67 67 -, ct dbSNP:141470287
82 82 a, t dbSNP:74094518
83 83 -, tctc dbSNP:546131783
84 84 a, t dbSNP:113949839
86 86 -, a dbSNP:758493433
124 124 c, g dbSNP:374443471
158 158 c, t dbSNP:568978172
165 165 c, t dbSNP:758462871
219 219 c, t dbSNP:533262937
227 227 c, g dbSNP:376536781
231 231 -, c dbSNP:759985332
238 238 a, g dbSNP:368991808
239 239 a, c dbSNP:373287161
248 248 c, g dbSNP:376595441
256 256 c, g, t dbSNP:759686993
259 259 g, t dbSNP:752771982
263 263 c, t dbSNP:762991374
264 264 c, g dbSNP:369524865
265 265 c, g, t dbSNP:373016496
272 272 a, g dbSNP:572862632
292 292 a, g dbSNP:757100419
304 304 a, c dbSNP:767359947
309 309 a, c dbSNP:750252178
325 325 a, g dbSNP:755757062
328 328 a, c dbSNP:779598315
331 331 a, g dbSNP:748811895
335 335 a, c, t dbSNP:34379766
335 335 -, c dbSNP:768059072
337 337 a, g dbSNP:778250041
354 354 a, g dbSNP:190034531
355 355 a, g dbSNP:771442726
360 360 a, g dbSNP:747687493
361 361 c, t dbSNP:757712749
365 365 c, t dbSNP:56017157
366 366 c, t dbSNP:746211618
373 373 c, t dbSNP:770120793
375 375 a, g dbSNP:775764667
391 391 a, g dbSNP:750029748
393 393 c, g, t dbSNP:749408634
394 394 a, g dbSNP:774536437
396 396 a, c, t dbSNP:762010415
397 397 a, g dbSNP:374953448
400 400 a, g dbSNP:760515344
403 403 a, g dbSNP:766147426
414 414 c, t dbSNP:753681468
419 419 c, t dbSNP:759044259
420 420 a, g dbSNP:764891356
422 422 -, tg dbSNP:764925612
434 434 a, g dbSNP:752180033
436 436 a, g dbSNP:757941835
439 439 a, t dbSNP:781661153
448 448 a, g dbSNP:750947241
450 450 a, g dbSNP:756656037
451 451 a, g dbSNP:780212356
457 457 a, g dbSNP:749691155
459 459 a, g dbSNP:552030360
470 470 c, t dbSNP:779330902
477 477 c, t dbSNP:748210428
479 479 c, t dbSNP:142735651
480 480 g, t dbSNP:760399408
486 486 a, c dbSNP:773189933
491 491 a, c dbSNP:570614098
492 492 c, t dbSNP:765693205
493 493 a, g, t dbSNP:143770796
507 507 a, g dbSNP:199806001
523 523 a, g dbSNP:748439445
525 525 g, t dbSNP:772436902
530 530 c, g dbSNP:777650340
534 534 c, t dbSNP:201378576
540 540 c, t dbSNP:770750571
541 541 a, g dbSNP:77228285
544 544 g, t dbSNP:759321206
556 556 a, g, t dbSNP:769634421
558 558 c, t dbSNP:762522193
562 562 a, g dbSNP:200856864
570 570 a, g dbSNP:773682670
571 571 c, t dbSNP:761437304
578 578 a, g, t dbSNP:201479792
579 579 c, t dbSNP:755384403
580 580 c, t dbSNP:765639633
582 582 a, c dbSNP:142358877
583 583 c, t dbSNP:146486757
584 584 a, g dbSNP:778104039
585 585 c, t dbSNP:747026534
590 590 g, t dbSNP:984896
591 591 a, g dbSNP:185577186
592 592 c, t dbSNP:757425458
593 593 a, g dbSNP:780976894
609 609 c, t dbSNP:745744610
611 611 a, g dbSNP:769723853
613 613 c, g dbSNP:375644422
630 630 c, t dbSNP:775223707
631 631 a, g dbSNP:759113437
635 635 c, t dbSNP:749101304
644 644 a, g dbSNP:768175062
663 663 c, t dbSNP:774095251
667 667 c, t dbSNP:761229179
670 670 c, t dbSNP:569206705
674 674 a, c dbSNP:540018426
676 676 c, t dbSNP:772863490
679 679 c, t dbSNP:760053751
680 680 a, g dbSNP:765878149
690 690 a, g dbSNP:369698449
696 696 c, t dbSNP:373473538
697 697 a, g dbSNP:764216267
708 708 -, a dbSNP:781058680
712 712 g, t dbSNP:746368473
713 713 c, g dbSNP:374619740
722 722 c, t dbSNP:748544096
723 723 a, t dbSNP:772486476
732 732 c, t dbSNP:147412657
733 733 a, g dbSNP:147905731
745 745 c, t dbSNP:141700623
756 756 a, c dbSNP:766619595
757 757 a, g dbSNP:188795493
760 760 a, g dbSNP:759585997
767 767 a, g dbSNP:560422339
772 772 a, g dbSNP:374643843
775 775 g, t dbSNP:758421385
780 780 a, g dbSNP:763914719
784 784 c, t dbSNP:751430378
785 785 a, g dbSNP:200978269
790 790 g, t dbSNP:780753707
797 797 c, t dbSNP:562044145
800 800 g, t dbSNP:745349643
814 814 c, g dbSNP:755643469
818 818 a, g dbSNP:371016430
824 824 g, t dbSNP:368392747
825 825 -, t dbSNP:749430896
826 826 a, c dbSNP:764505233
828 828 c, t dbSNP:755808253
830 830 c, g dbSNP:779368926
831 831 a, c dbSNP:372292404
832 832 g, t dbSNP:748832619
832 832 -, t dbSNP:771162961
852 852 a, g dbSNP:188312953
854 854 a, g dbSNP:561743080
858 858 c, t dbSNP:747344439
869 869 g, t dbSNP:150454821
874 874 a, g dbSNP:146860437
875 875 a, g dbSNP:771269574
887 887 c, t dbSNP:56107455
888 888 a, c, t dbSNP:746010261
896 896 a, g dbSNP:752120492
899 899 c, t dbSNP:757785908
936 936 c, g dbSNP:781370237
941 941 a, g dbSNP:767977511
942 942 a, c dbSNP:769880860
946 946 a, t dbSNP:549747369
951 951 g, t dbSNP:749372152
953 953 a, g dbSNP:768913280
959 959 a, g dbSNP:774589520
961 961 a, g dbSNP:201079200
965 965 a, t dbSNP:772081729
967 967 g, t dbSNP:376656358
970 970 a, g, t dbSNP:140656187
972 972 c, t dbSNP:79638498
973 973 a, g dbSNP:753556193
975 975 a, g dbSNP:750546129
1005 1005 a, c dbSNP:764658539
1015 1015 c, t dbSNP:767905298
1016 1016 a, g dbSNP:374485725
1025 1025 a, g dbSNP:756590738
1029 1029 c, t dbSNP:766784893
1037 1037 a, c dbSNP:375740977
1048 1048 c, t dbSNP:755202592
1063 1063 c, t dbSNP:370272057
1066 1066 a, g dbSNP:748150381
1067 1067 c, t dbSNP:758573987
1070 1070 -, aca dbSNP:768003972
1075 1075 a, t dbSNP:777560897
1078 1078 c, t dbSNP:746909010
1080 1080 a, g dbSNP:770884727
1083 1083 c, t dbSNP:776358318
1086 1086 c, t dbSNP:745708003
1105 1105 c, t dbSNP:769400680
1109 1109 c, t dbSNP:775279860
1110 1110 c, g dbSNP:374000753
1112 1112 a, g dbSNP:763600586
1129 1129 a, g dbSNP:149635848
1145 1145 a, g dbSNP:143406438
1148 1148 c, t dbSNP:767016749
1150 1150 c, t dbSNP:754234296
1168 1168 c, g dbSNP:748901952
1175 1175 -, c dbSNP:775916001
1186 1186 g, t dbSNP:768226214
1212 1212 a, g dbSNP:773864864
1217 1217 a, g dbSNP:137870123
1233 1233 a, g dbSNP:372826813
1240 1240 c, t dbSNP:770284356
1244 1244 g, t dbSNP:771534313
1246 1246 a, g dbSNP:375335792
1253 1253 c, t dbSNP:780746041
1256 1256 c, g dbSNP:759969948
1261 1261 -, aa dbSNP:761253211
1282 1282 c, t dbSNP:775899344
1291 1291 c, g, t dbSNP:763264762
1292 1292 a, g dbSNP:751837696
1310 1310 c, t dbSNP:762035321
1311 1311 a, g dbSNP:767516997
1325 1325 c, g dbSNP:750531252
1335 1335 c, t dbSNP:756031721
1337 1337 a, g dbSNP:766278040
1338 1338 c, t dbSNP:753637842
1347 1347 c, t dbSNP:140648008
1365 1365 c, t dbSNP:778618876
1374 1374 c, t dbSNP:747748100
1375 1375 a, g dbSNP:758130617
1377 1377 a, c dbSNP:777380336
1382 1382 a, g dbSNP:200211366
1390 1390 c, g dbSNP:763820950
1391 1391 c, g dbSNP:751110954
1393 1393 c, t dbSNP:371094129
1394 1394 a, g dbSNP:780527140
1416 1416 c, t dbSNP:749968833
1422 1422 a, g dbSNP:530971245
1425 1425 a, g dbSNP:779437595
1430 1430 a, g dbSNP:12320176
1437 1437 -, c dbSNP:752509988
1438 1438 c, t dbSNP:772484121
1439 1439 a, g dbSNP:570637025
1446 1446 a, g dbSNP:747136840
1447 1447 c, t dbSNP:139868331
1448 1448 a, g dbSNP:776526512
1484 1484 c, t dbSNP:370847503
1485 1485 a, g dbSNP:760334728
1492 1492 a, c dbSNP:765810588
1493 1493 g, t dbSNP:770069064
1500 1500 c, g dbSNP:753381982
1501 1501 c, t dbSNP:758858885
1505 1505 g, t dbSNP:764713576
1516 1516 a, c dbSNP:74763375
1519 1519 c, t dbSNP:751842876
1527 1527 c, t dbSNP:757695889
1528 1528 a, g dbSNP:201880960
1529 1529 a, c, t dbSNP:141230043
1530 1530 g, t dbSNP:756432396
1536 1536 a, c, g dbSNP:201663351
1538 1538 a, g dbSNP:768445052
1547 1547 a, g dbSNP:774415293
1552 1552 c, t dbSNP:375932235
1557 1557 c, t dbSNP:200737450
1561 1561 -, c dbSNP:34331509
1564 1564 c, t dbSNP:750839021
1571 1571 c, t dbSNP:756381479
1581 1581 c, g, t dbSNP:199613777
1584 1584 a, g dbSNP:2229045
1602 1602 c, g, t dbSNP:200855296
1603 1603 a, t dbSNP:748051476
1606 1606 c, t dbSNP:771935902
1607 1607 a, g dbSNP:777498890
1623 1623 c, t dbSNP:2229046
1632 1632 c, g dbSNP:770543666
1633 1633 c, t dbSNP:776335440
1634 1634 a, g dbSNP:144549266
1641 1641 c, t dbSNP:367629214
1642 1642 a, g dbSNP:200007116
1653 1653 c, t dbSNP:750292694
1657 1657 a, c dbSNP:756039555
1659 1659 g, t dbSNP:750783773
1692 1692 c, g dbSNP:761188556
1700 1700 a, g dbSNP:372171124
1701 1701 a, g dbSNP:754056576
1702 1702 g, t dbSNP:765931642
1703 1703 a, g dbSNP:755162824
1704 1704 a, g dbSNP:779013163
1707 1707 c, t dbSNP:752745097
1710 1710 a, g, t dbSNP:758336051
1718 1718 c, g dbSNP:746806935
1722 1722 a, g dbSNP:770651825
1726 1726 a, c dbSNP:546727763
1739 1739 a, g dbSNP:780965539
1742 1742 c, t dbSNP:745490480
1743 1743 a, c, g dbSNP:544630584
1744 1744 c, t dbSNP:775042280
1745 1745 a, g dbSNP:149951770
1755 1755 c, t dbSNP:754618467
1756 1756 g, t dbSNP:182692782
1765 1765 a, g dbSNP:375153329
1769 1769 a, t dbSNP:146593760
1773 1773 g, t dbSNP:777034879
1791 1791 c, t dbSNP:759860285
1799 1799 c, g, t dbSNP:765496438
1801 1801 a, t dbSNP:763162378
1805 1805 -, g dbSNP:750392197
1814 1814 a, g dbSNP:145108143
1815 1815 -, at dbSNP:745930963
1815 1815 c, t dbSNP:186080571
1817 1817 -, ct dbSNP:771983298
1819 1819 a, g dbSNP:751658102
1827 1827 c, t dbSNP:140670767
1830 1830 c, g, t dbSNP:572923795
1837 1837 a, c dbSNP:755919824
1838 1838 a, g dbSNP:779911233
1840 1840 a, t dbSNP:748825294
1843 1843 c, t dbSNP:754708975
1844 1844 a, g dbSNP:530169899
1845 1845 c, t dbSNP:778519373
1849 1849 a, c, t dbSNP:543942622
1850 1850 a, g dbSNP:771536549
1857 1857 c, t dbSNP:777074650
1862 1862 g, t dbSNP:746234503
1866 1866 c, g dbSNP:55880327
1867 1867 a, t dbSNP:200670489
1872 1872 c, t dbSNP:763108970
1873 1873 c, t dbSNP:147888915
1886 1886 a, g dbSNP:774380215
1898 1898 a, g dbSNP:759562930
1914 1914 a, g dbSNP:267603577
1915 1915 a, g dbSNP:267603578
1917 1917 c, t dbSNP:377479010
1918 1918 c, g dbSNP:762488062
1923 1923 -, ctt dbSNP:759266496
1924 1924 c, t dbSNP:569403749
1926 1926 -, ctc dbSNP:766897145
1927 1927 g, t dbSNP:751025983
1928 1928 c, t dbSNP:201942735
1937 1937 c, t dbSNP:370634710
1938 1938 a, g dbSNP:754275955
1949 1949 c, t dbSNP:755509709
1950 1950 c, g dbSNP:567366033
1957 1957 a, g dbSNP:202048840
1974 1974 c, t dbSNP:779200761
1979 1979 c, t dbSNP:748595358
1980 1980 a, g dbSNP:746440071
1981 1981 c, g dbSNP:368322587
1994 1994 a, g dbSNP:758858051
1999 1999 c, g dbSNP:370896872
2001 2001 a, g dbSNP:201112536
2003 2003 a, g dbSNP:748808887
2005 2005 a, g dbSNP:141636701
2007 2007 c, t dbSNP:757588784
2010 2010 c, t dbSNP:781395095
2014 2014 c, t dbSNP:371577741
2015 2015 a, g dbSNP:200350558
2047 2047 c, t dbSNP:769847060
2050 2050 a, g dbSNP:775624369
2056 2056 c, t dbSNP:56073151
2058 2058 a, c dbSNP:768429976
2069 2069 g, t dbSNP:774044496
2078 2078 a, g dbSNP:761478277
2088 2088 a, c dbSNP:201250912
2095 2095 c, t dbSNP:772678619
2097 2097 -, g dbSNP:755981274
2106 2106 g, t dbSNP:760246763
2107 2107 c, t dbSNP:373609369
2109 2109 c, g dbSNP:753193028
2112 2112 c, g dbSNP:763378170
2116 2116 c, g dbSNP:200574817
2119 2119 a, g dbSNP:143726790
2121 2121 a, g dbSNP:745899873
2127 2127 c, t dbSNP:751896559
2129 2129 c, t dbSNP:757518347
2147 2147 c, g dbSNP:151083303
2149 2149 a, g dbSNP:756434433
2155 2155 c, t dbSNP:780132789
2170 2170 a, c, g dbSNP:544678821
2176 2176 c, g dbSNP:778783934
2178 2178 c, g dbSNP:55702663
2179 2179 a, g dbSNP:141054346
2187 2187 c, t dbSNP:150262923
2195 2195 a, c, t dbSNP:753940174
2201 2201 c, t dbSNP:371005132
2203 2203 a, c dbSNP:752570404
2207 2207 c, t dbSNP:758350871
2225 2225 a, c dbSNP:772987101
2230 2230 c, t dbSNP:777500852
2246 2246 c, t dbSNP:746842107
2249 2249 c, t dbSNP:756926213
2255 2255 c, g dbSNP:369758674
2256 2256 c, t dbSNP:746888057
2257 2257 a, g dbSNP:139022684
2262 2262 -, t dbSNP:757097775
2264 2264 -, ttctc dbSNP:778689388
2275 2275 c, t dbSNP:775164134
2281 2281 c, t dbSNP:200724560
2282 2282 a, g dbSNP:772747085
2284 2284 c, t dbSNP:773690291
2285 2285 a, g dbSNP:761002408
2286 2286 a, g dbSNP:766618651
2298 2298 a, c dbSNP:373838865
2317 2317 c, t dbSNP:142303928
2319 2319 a, g dbSNP:377676879
2323 2323 c, t dbSNP:56387488
2324 2324 a, g dbSNP:765179217
2325 2325 c, g dbSNP:752803014
2326 2326 c, g dbSNP:758297377
2327 2327 a, g dbSNP:764063127
2334 2334 c, g dbSNP:138548737
2342 2342 c, t dbSNP:777073878
2347 2347 a, g dbSNP:759635172
2351 2351 a, c, g dbSNP:181659329
2354 2354 c, g dbSNP:763091526
2368 2368 a, g dbSNP:368508813
2373 2373 c, g dbSNP:759676510
2392 2392 c, g dbSNP:371866354
2394 2394 a, g dbSNP:767179070
2424 2424 c, t dbSNP:79293052
2426 2426 c, t dbSNP:35961836
2427 2427 a, g dbSNP:755700670
2434 2434 -, tt dbSNP:772365638
2436 2436 a, t dbSNP:779910792
2443 2443 c, g dbSNP:189789018
2455 2455 g, t dbSNP:752289630
2468 2468 -, a dbSNP:747154798
2470 2470 a, g dbSNP:757680970
2505 2505 a, c dbSNP:368720651
2507 2507 c, t dbSNP:55787439
2517 2517 c, g dbSNP:760414488
2523 2523 a, c dbSNP:780421722
2524 2524 c, t dbSNP:373831196
2525 2525 a, g dbSNP:770870486
2528 2528 a, g dbSNP:774273587
2538 2538 a, g dbSNP:748319015
2540 2540 c, t dbSNP:771899301
2546 2546 c, t dbSNP:773134874
2548 2548 c, g, t dbSNP:3891921
2549 2549 a, g dbSNP:776486535
2556 2556 a, g dbSNP:759458720
2558 2558 c, t dbSNP:764788295
2560 2560 c, g dbSNP:775138327
2584 2584 c, t dbSNP:371109792
2594 2594 a, g dbSNP:763623076
2615 2615 a, g dbSNP:202221237
2616 2616 a, g dbSNP:201309981
2629 2629 c, t dbSNP:766932138
2631 2631 a, t dbSNP:754198128
2652 2652 a, g dbSNP:755304842
2659 2659 c, g, t dbSNP:144510847
2666 2666 a, g dbSNP:758578409
2677 2677 a, c dbSNP:777968329
2680 2680 c, t dbSNP:148448153
2682 2682 c, g dbSNP:375732870
2683 2683 c, t dbSNP:747131244
2684 2684 a, g dbSNP:770976516
2687 2687 g, t dbSNP:182154425
2689 2689 c, g dbSNP:80185484
2690 2690 c, t dbSNP:745801537
2694 2694 c, g dbSNP:113375878
2697 2697 c, g dbSNP:769586905
2717 2717 a, g dbSNP:775183935
2729 2729 c, t dbSNP:762638258
2730 2730 c, t dbSNP:768244757
2733 2733 c, t dbSNP:773839032
2742 2742 a, g dbSNP:769661725
2748 2748 c, t dbSNP:201892971
2749 2749 c, g dbSNP:576617052
2750 2750 c, t dbSNP:754433840
2759 2759 a, g dbSNP:749096091
2760 2760 c, t dbSNP:768352400
2763 2763 c, t dbSNP:773926940
2772 2772 c, t dbSNP:543742419
2789 2789 a, g dbSNP:771520731
2793 2793 c, t dbSNP:558851810
2794 2794 a, g dbSNP:576402458
2801 2801 g, t dbSNP:760055268
2805 2805 a, g dbSNP:201149603
2808 2808 a, t dbSNP:141739894
2809 2809 c, g dbSNP:147206496
2812 2812 a, g dbSNP:764554418
2817 2817 a, g dbSNP:751770045
2820 2820 c, t dbSNP:757588627
2828 2828 c, t dbSNP:781394944
2829 2829 a, c dbSNP:558975107
2848 2848 -, ctg dbSNP:769041526
2866 2866 a, g dbSNP:756068516
2871 2871 g, t dbSNP:779924065
2872 2872 c, t dbSNP:140606920
2878 2878 c, t dbSNP:749255674
2882 2882 a, g dbSNP:143021252
2883 2883 c, t dbSNP:541947408
2887 2887 g, t dbSNP:778703567
2899 2899 a, t dbSNP:746673930
2919 2919 a, c, g dbSNP:377181290
2925 2925 a, c, t dbSNP:749784326
2949 2949 a, g dbSNP:774847268
2952 2952 c, t dbSNP:762337678
2977 2977 a, c, g dbSNP:765301443
2985 2985 a, g dbSNP:762898008
2986 2986 c, t dbSNP:763753546
2990 2990 c, t dbSNP:751422999
2993 2993 c, g dbSNP:371250480
2997 2997 c, t dbSNP:780969100
2998 2998 a, g dbSNP:776280433
3007 3007 a, c dbSNP:750109086
3013 3013 a, g dbSNP:144558290
3018 3018 a, g dbSNP:199524175
3022 3022 c, t dbSNP:748627495
3023 3023 a, g dbSNP:548359026
3025 3025 c, t dbSNP:375212605
3042 3042 c, t dbSNP:747462791
3045 3045 g, t dbSNP:771054853
3051 3051 a, g dbSNP:369435312
3055 3055 a, g dbSNP:776766992
3061 3061 c, t dbSNP:759764423
3062 3062 a, g dbSNP:769811937
3064 3064 c, t dbSNP:570154608
3071 3071 a, c dbSNP:762765641
3078 3078 c, g dbSNP:193920754
3081 3081 c, t dbSNP:764152740
3089 3089 a, t dbSNP:774015628
3099 3099 c, t dbSNP:373474079
3125 3125 c, t dbSNP:540444132
3126 3126 c, t dbSNP:757732235
3140 3140 a, g dbSNP:781502670
3150 3150 a, t dbSNP:746277687
3157 3157 c, t dbSNP:756327666
3160 3160 a, g dbSNP:60586767
3176 3176 a, g dbSNP:561787077
3177 3177 a, g dbSNP:754129713
3184 3184 c, t dbSNP:768736698
3185 3185 a, g dbSNP:774326613
3197 3197 a, g dbSNP:376939275
3207 3207 a, c, g dbSNP:772186703
3217 3217 c, g dbSNP:777784585
3227 3227 c, g dbSNP:746955432
3230 3230 a, g dbSNP:770800582
3233 3233 g, t dbSNP:776317437
3237 3237 c, t dbSNP:759192377
3247 3247 a, g dbSNP:372311528
3250 3250 c, t dbSNP:769377225
3254 3254 a, g dbSNP:775048781
3255 3255 c, t dbSNP:111656432
3269 3269 a, g dbSNP:56259600
3283 3283 a, g dbSNP:549592321
3295 3295 c, t dbSNP:750884386
3298 3298 c, g dbSNP:761205665
3300 3300 -, ctagac dbSNP:755187499
3316 3316 c, g dbSNP:766735121
3324 3324 a, g, t dbSNP:368317187
3328 3328 -, gag dbSNP:781370860
3328 3328 a, g dbSNP:779069907
3333 3333 c, g dbSNP:139267530
3339 3339 c, g dbSNP:758492908
3347 3347 a, c dbSNP:150001629
3348 3348 c, t dbSNP:746899911
3352 3352 a, g dbSNP:770810033
3355 3355 a, c dbSNP:781015952
3363 3363 c, t dbSNP:145259354
3364 3364 a, g dbSNP:370221639
3367 3367 c, t dbSNP:774951032
3376 3376 c, t dbSNP:748965595
3378 3378 a, t dbSNP:768118549
3379 3379 c, g, t dbSNP:370849499
3394 3394 c, t dbSNP:200017094
3395 3395 a, g dbSNP:149181380
3400 3400 c, t dbSNP:777051335
3401 3401 a, g, t dbSNP:759751183
3408 3408 c, g dbSNP:747724574
3412 3412 a, c dbSNP:771613701
3415 3415 a, c dbSNP:776943898
3421 3421 a, c, g dbSNP:151311358
3425 3425 -, cat dbSNP:768349544
3434 3434 c, g dbSNP:373276051
3441 3441 g, t dbSNP:17118292
3444 3444 a, c dbSNP:776033298
3455 3455 a, g dbSNP:375145270
3457 3457 a, c dbSNP:764464919
3461 3461 c, t dbSNP:751682177
3464 3464 a, g dbSNP:757229785
3466 3466 c, g dbSNP:767661045
3469 3469 c, t dbSNP:750291956
3473 3473 a, g dbSNP:756121964
3474 3474 c, t dbSNP:779802097
3477 3477 a, g dbSNP:142406728
3483 3483 c, t dbSNP:767467479
3484 3484 a, g dbSNP:750564739
3491 3491 c, t dbSNP:760520385
3493 3493 c, g dbSNP:540419748
3495 3495 a, c, g dbSNP:369994613
3505 3505 c, t dbSNP:112651994
3506 3506 a, g dbSNP:752248295
3513 3513 c, t dbSNP:529498703
3514 3514 c, t dbSNP:373840207
3515 3515 a, g dbSNP:376234145
3529 3529 c, t dbSNP:770418548
3530 3530 a, g dbSNP:780639000
3535 3535 a, g dbSNP:749837397
3541 3541 c, t dbSNP:551223118
3542 3542 a, g dbSNP:774819745
3547 3547 g, t dbSNP:761919744
3548 3548 a, g dbSNP:762684981
3554 3554 -, catcagagt dbSNP:766158165
3554 3554 c, t dbSNP:768349999
3560 3560 a, c dbSNP:772400489
3565 3565 c, t dbSNP:77822103
3593 3593 -, g dbSNP:751333751
3594 3594 c, t dbSNP:760684405
3598 3598 c, t dbSNP:766463645
3601 3601 c, t dbSNP:753723245
3604 3604 a, g dbSNP:532910077
3606 3606 c, g dbSNP:551404301
3610 3610 a, c, g dbSNP:752581968
3611 3611 c, t dbSNP:777547093
3616 3616 a, c dbSNP:751174259
3617 3617 c, t dbSNP:756767445
3624 3624 a, g dbSNP:2271189
3628 3628 c, t dbSNP:138517750
3629 3629 a, c, g dbSNP:201958747
3631 3631 a, t dbSNP:773123
3632 3632 a, g dbSNP:772330811
3640 3640 c, t dbSNP:773429549
3641 3641 a, g dbSNP:747256428
3646 3646 c, t dbSNP:770956274
3649 3649 a, c, t dbSNP:776728303
3650 3650 a, g dbSNP:765277521
3653 3653 c, g, t dbSNP:201486425
3655 3655 c, t dbSNP:763808045
3656 3656 a, g dbSNP:2271188
3657 3657 c, t dbSNP:757012593
3667 3667 a, g dbSNP:150312718
3670 3670 c, t dbSNP:750011302
3674 3674 a, g dbSNP:755540867
3680 3680 a, g dbSNP:779413213
3682 3682 a, c, t dbSNP:79759315
3683 3683 a, g dbSNP:758743468
3695 3695 c, t dbSNP:557728984
3696 3696 g, t dbSNP:137983681
3700 3700 c, t dbSNP:771187693
3709 3709 c, g dbSNP:776675136
3710 3710 c, t dbSNP:746015375
3721 3721 c, g dbSNP:769768196
3723 3723 c, g dbSNP:775439390
3725 3725 a, c, g dbSNP:149495975
3726 3726 c, g dbSNP:774338322
3736 3736 g, t dbSNP:761544555
3741 3741 c, t dbSNP:767345764
3747 3747 c, t dbSNP:147189912
3748 3748 a, g, t dbSNP:755595923
3757 3757 a, t dbSNP:764225931
3765 3765 c, t dbSNP:377479457
3766 3766 a, g dbSNP:370634525
3770 3770 a, g dbSNP:758866721
3779 3779 a, g dbSNP:776195897
3785 3785 -, cct dbSNP:768296093
3793 3793 c, t dbSNP:180986542
3794 3794 a, c, g dbSNP:138861245
3803 3803 a, c dbSNP:375222170
3805 3805 a, c, g dbSNP:55699040
3839 3839 c, t dbSNP:750813770
3841 3841 -, gaa dbSNP:780883720
3852 3852 c, t dbSNP:200811061
3859 3859 -, gag dbSNP:769797702
3861 3861 a, g dbSNP:766445884
3862 3862 a, g dbSNP:754106965
3863 3863 a, g dbSNP:147436223
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3870 3870 a, c dbSNP:748071169
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3881 3881 a, g dbSNP:373454755
3885 3885 a, g dbSNP:770761268
3891 3891 a, g dbSNP:776088161
3893 3893 a, g dbSNP:745555924
3910 3910 c, t dbSNP:769251414
3936 3936 c, g dbSNP:775019515
3937 3937 c, g dbSNP:762295587
3950 3950 c, t dbSNP:768081452
4017 4017 c, t dbSNP:773773362
4026 4026 c, t dbSNP:760891277
4027 4027 a, c dbSNP:371152673
4028 4028 c, g dbSNP:766792372
4029 4029 g, t dbSNP:753971721
4035 4035 c, t dbSNP:755294151
4037 4037 a, c dbSNP:55709407
4039 4039 a, g dbSNP:577222787
4047 4047 c, t dbSNP:765388650
4055 4055 a, t dbSNP:377380727
4062 4062 c, t dbSNP:758402895
4065 4065 a, g dbSNP:267603579
4068 4068 a, t dbSNP:777501187
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4070 4070 a, c, g dbSNP:142809206
4075 4075 c, t dbSNP:745487835
4076 4076 a, g dbSNP:538526313
4080 4080 c, t dbSNP:755800903
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4092 4092 -, g dbSNP:747814172
4092 4092 c, t dbSNP:748730380
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4125 4125 a, t dbSNP:139774513
4140 4140 g, t dbSNP:777106152
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4147 4147 -, gagat dbSNP:769228905
4151 4151 c, t dbSNP:765619131
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4164 4164 a, g dbSNP:779896968
4167 4167 g, t dbSNP:764254944
4168 4168 a, c dbSNP:751413071
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4211 4211 -, ct dbSNP:762900471
4211 4211 c, t dbSNP:771529756
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4785 4785 a, g dbSNP:560635272
4866 4866 g, t dbSNP:762190552
4897 4897 a, g dbSNP:545874178
4934 4934 g, t dbSNP:556562151
4940 4940 c, t dbSNP:527249652
4941 4941 c, g dbSNP:760370003
4991 4991 c, g dbSNP:139969906
5002 5002 c, t dbSNP:12322914
5044 5044 a, c dbSNP:531304096
5056 5056 -, a dbSNP:751543695
5057 5057 -, aaa dbSNP:150235513
5079 5079 a, c dbSNP:61632170
5082 5082 -, aaa dbSNP:569620844
5082 5082 a, c dbSNP:376657820
5084 5084 -, aaa, aaaa dbSNP:4016497
5090 5090 a, g dbSNP:146076136
5171 5171 g, t dbSNP:187008330
5205 5205 -, tg dbSNP:577236188
5206 5206 -, gt dbSNP:369073558
5215 5215 a, g dbSNP:571095209
5219 5219 a, g dbSNP:369874280
5238 5238 a, g dbSNP:547261509
5266 5266 a, g dbSNP:765576656
5294 5294 a, g dbSNP:565840792
5319 5319 a, g dbSNP:191973437
5370 5370 c, g dbSNP:534155843
5405 5405 a, c dbSNP:78743019
5416 5416 c, t dbSNP:555468041
5460 5460 c, g, t dbSNP:76373339
5482 5482 a, g dbSNP:538319940
5500 5500 a, g dbSNP:183300184
5533 5533 -, ctt dbSNP:559078261
5577 5577 a, t dbSNP:750698065
5614 5614 c, t dbSNP:763487393
5641 5641 c, t dbSNP:149441887
5644 5644 c, t dbSNP:559512976
5673 5673 -, a dbSNP:563581883
5678 5678 a, g dbSNP:188400828
5682 5682 cg, tgtc dbSNP:386763282
5682 5682 c, t dbSNP:190031571
5683 5683 -, tc dbSNP:145070592
5683 5683 a, g dbSNP:182361805
5696 5696 c, t dbSNP:761827109
5697 5697 c, t dbSNP:767787815
5707 5707 c, t dbSNP:541949168
5734 5734 a, c dbSNP:750680918
5745 5745 -, t dbSNP:112478453
5746 5746 a, t dbSNP:144785344
5757 5757 c, g dbSNP:148560992

Target ORF information:

RefSeq Version NM_001982
Organism Homo sapiens (human)
Definition Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001982

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
ATGAGGGCGA ACGACGCTCT GCAGGTGCTG GGCTTGCTTT TCAGCCTGGC CCGGGGCTCC 
GAGGTGGGCA ACTCTCAGGC AGTGTGTCCT GGGACTCTGA ATGGCCTGAG TGTGACCGGC
GATGCTGAGA ACCAATACCA GACACTGTAC AAGCTCTACG AGAGGTGTGA GGTGGTGATG
GGGAACCTTG AGATTGTGCT CACGGGACAC AATGCCGACC TCTCCTTCCT GCAGTGGATT
CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAATGAAT TCTCTACTCT ACCATTGCCC
AACCTCCGCG TGGTGCGAGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTCGTCATG
TTGAACTATA ACACCAACTC CAGCCACGCT CTGCGCCAGC TCCGCTTGAC TCAGCTCACC
GAGATTCTGT CAGGGGGTGT TTATATTGAG AAGAACGATA AGCTTTGTCA CATGGACACA
ATTGACTGGA GGGACATCGT GAGGGACCGA GATGCTGAGA TAGTGGTGAA GGACAATGGC
AGAAGCTGTC CCCCCTGTCA TGAGGTTTGC AAGGGGCGAT GCTGGGGTCC TGGATCAGAA
GACTGCCAGA CATTGACCAA GACCATCTGT GCTCCTCAGT GTAATGGTCA CTGCTTTGGG
CCCAACCCCA ACCAGTGCTG CCATGATGAG TGTGCCGGGG GCTGCTCAGG CCCTCAGGAC
ACAGACTGCT TTGCCTGCCG GCACTTCAAT GACAGTGGAG CCTGTGTACC TCGCTGTCCA
CAGCCTCTTG TCTACAACAA GCTAACTTTC CAGCTGGAAC CCAATCCCCA CACCAAGTAT
CAGTATGGAG GAGTTTGTGT AGCCAGCTGT CCCCATAACT TTGTGGTGGA TCAAACATCC
TGTGTCAGGG CCTGTCCTCC TGACAAGATG GAAGTAGATA AAAATGGGCT CAAGATGTGT
GAGCCTTGTG GGGGACTATG TCCCAAAGCC TGTGAGGGAA CAGGCTCTGG GAGCCGCTTC
CAGACTGTGG ACTCGAGCAA CATTGATGGA TTTGTGAACT GCACCAAGAT CCTGGGCAAC
CTGGACTTTC TGATCACCGG CCTCAATGGA GACCCCTGGC ACAAGATCCC TGCCCTGGAC
CCAGAGAAGC TCAATGTCTT CCGGACAGTA CGGGAGATCA CAGGTTACCT GAACATCCAG
TCCTGGCCGC CCCACATGCA CAACTTCAGT GTTTTTTCCA ATTTGACAAC CATTGGAGGC
AGAAGCCTCT ACAACCGGGG CTTCTCATTG TTGATCATGA AGAACTTGAA TGTCACATCT
CTGGGCTTCC GATCCCTGAA GGAAATTAGT GCTGGGCGTA TCTATATAAG TGCCAATAGG
CAGCTCTGCT ACCACCACTC TTTGAACTGG ACCAAGGTGC TTCGGGGGCC TACGGAAGAG
CGACTAGACA TCAAGCATAA TCGGCCGCGC AGAGACTGCG TGGCAGAGGG CAAAGTGTGT
GACCCACTGT GCTCCTCTGG GGGATGCTGG GGCCCAGGCC CTGGTCAGTG CTTGTCCTGT
CGAAATTATA GCCGAGGAGG TGTCTGTGTG ACCCACTGCA ACTTTCTGAA TGGGGAGCCT
CGAGAATTTG CCCATGAGGC CGAATGCTTC TCCTGCCACC CGGAATGCCA ACCCATGGAG
GGCACTGCCA CATGCAATGG CTCGGGCTCT GATACTTGTG CTCAATGTGC CCATTTTCGA
GATGGGCCCC ACTGTGTGAG CAGCTGCCCC CATGGAGTCC TAGGTGCCAA GGGCCCAATC
TACAAGTACC CAGATGTTCA GAATGAATGT CGGCCCTGCC ATGAGAACTG CACCCAGGGG
TGTAAAGGAC CAGAGCTTCA AGACTGTTTA GGACAAACAC TGGTGCTGAT CGGCAAAACC
CATCTGACAA TGGCTTTGAC AGTGATAGCA GGATTGGTAG TGATTTTCAT GATGCTGGGC
GGCACTTTTC TCTACTGGCG TGGGCGCCGG ATTCAGAATA AAAGGGCTAT GAGGCGATAC
TTGGAACGGG GTGAGAGCAT AGAGCCTCTG GACCCCAGTG AGAAGGCTAA CAAAGTCTTG
GCCAGAATCT TCAAAGAGAC AGAGCTAAGG AAGCTTAAAG TGCTTGGCTC GGGTGTCTTT
GGAACTGTGC ACAAAGGAGT GTGGATCCCT GAGGGTGAAT CAATCAAGAT TCCAGTCTGC
ATTAAAGTCA TTGAGGACAA GAGTGGACGG CAGAGTTTTC AAGCTGTGAC AGATCATATG
CTGGCCATTG GCAGCCTGGA CCATGCCCAC ATTGTAAGGC TGCTGGGACT ATGCCCAGGG
TCATCTCTGC AGCTTGTCAC TCAATATTTG CCTCTGGGTT CTCTGCTGGA TCATGTGAGA
CAACACCGGG GGGCACTGGG GCCACAGCTG CTGCTCAACT GGGGAGTACA AATTGCCAAG
GGAATGTACT ACCTTGAGGA ACATGGTATG GTGCATAGAA ACCTGGCTGC CCGAAACGTG
CTACTCAAGT CACCCAGTCA GGTTCAGGTG GCAGATTTTG GTGTGGCTGA CCTGCTGCCT
CCTGATGATA AGCAGCTGCT ATACAGTGAG GCCAAGACTC CAATTAAGTG GATGGCCCTT
GAGAGTATCC ACTTTGGGAA ATACACACAC CAGAGTGATG TCTGGAGCTA TGGTGTGACA
GTTTGGGAGT TGATGACCTT CGGGGCAGAG CCCTATGCAG GGCTACGATT GGCTGAAGTA
CCAGACCTGC TAGAGAAGGG GGAGCGGTTG GCACAGCCCC AGATCTGCAC AATTGATGTC
TACATGGTGA TGGTCAAGTG TTGGATGATT GATGAGAACA TTCGCCCAAC CTTTAAAGAA
CTAGCCAATG AGTTCACCAG GATGGCCCGA GACCCACCAC GGTATCTGGT CATAAAGAGA
GAGAGTGGGC CTGGAATAGC CCCTGGGCCA GAGCCCCATG GTCTGACAAA CAAGAAGCTA
GAGGAAGTAG AGCTGGAGCC AGAACTAGAC CTAGACCTAG ACTTGGAAGC AGAGGAGGAC
AACCTGGCAA CCACCACACT GGGCTCCGCC CTCAGCCTAC CAGTTGGAAC ACTTAATCGG
CCACGTGGGA GCCAGAGCCT TTTAAGTCCA TCATCTGGAT ACATGCCCAT GAACCAGGGT
AATCTTGGGG AGTCTTGCCA GGAGTCTGCA GTTTCTGGGA GCAGTGAACG GTGCCCCCGT
CCAGTCTCTC TACACCCAAT GCCACGGGGA TGCCTGGCAT CAGAGTCATC AGAGGGGCAT
GTAACAGGCT CTGAGGCTGA GCTCCAGGAG AAAGTGTCAA TGTGTAGGAG CCGGAGCAGG
AGCCGGAGCC CACGGCCACG CGGAGATAGC GCCTACCATT CCCAGCGCCA CAGTCTGCTG
ACTCCTGTTA CCCCACTCTC CCCACCCGGG TTAGAGGAAG AGGATGTCAA CGGTTATGTC
ATGCCAGATA CACACCTCAA AGGTACTCCC TCCTCCCGGG AAGGCACCCT TTCTTCAGTG
GGTCTCAGTT CTGTCCTGGG TACTGAAGAA GAAGATGAAG ATGAGGAGTA TGAATACATG
AACCGGAGGA GAAGGCACAG TCCACCTCAT CCCCCTAGGC CAAGTTCCCT TGAGGAGCTG
GGTTATGAGT ACATGGATGT GGGGTCAGAC CTCAGTGCCT CTCTGGGCAG CACACAGAGT
TGCCCACTCC ACCCTGTACC CATCATGCCC ACTGCAGGCA CAACTCCAGA TGAAGACTAT
GAATATATGA ATCGGCAACG AGATGGAGGT GGTCCTGGGG GTGATTATGC AGCCATGGGG
GCCTGCCCAG CATCTGAGCA AGGGTATGAA GAGATGAGAG CTTTTCAGGG GCCTGGACAT
CAGGCCCCCC ATGTCCATTA TGCCCGCCTA AAAACTCTAC GTAGCTTAGA GGCTACAGAC
TCTGCCTTTG ATAACCCTGA TTACTGGCAT AGCAGGCTTT TCCCCAAGGC TAATGCCCAG
AGAACGTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu20847D
Sequence Information ORF Nucleotide Sequence (Length: 552bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-3 isoform s precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M34309.1, AC034102.32 and S61953.1. Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (s) lacks many 3' exons found in variant 1 and contains an alternate 3' exon of its own, that causes a frameshift. The resulting isoform (s) is shorter lacking the intermembrane region present in isoform 1, and is secreted outside the cell. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA404839.1, AL554815.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGAGGGCGA ACGACGCTCT GCAGGTGCTG GGCTTGCTTT TCAGCCTGGC CCGGGGCTCC 
GAGGTGGGCA ACTCTCAGGC AGTGTGTCCT GGGACTCTGA ATGGCCTGAG TGTGACCGGC
GATGCTGAGA ACCAATACCA GACACTGTAC AAGCTCTACG AGAGGTGTGA GGTGGTGATG
GGGAACCTTG AGATTGTGCT CACGGGACAC AATGCCGACC TCTCCTTCCT GCAGTGGATT
CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAATGAAT TCTCTACTCT ACCATTGCCC
AACCTCCGCG TGGTGCGAGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTCGTCATG
TTGAACTATA ACACCAACTC CAGCCACGCT CTGCGCCAGC TCCGCTTGAC TCAGCTCACC
GGTCAGTTCC CGATGGTTCC TTCTGGCCTC ACCCCTCAGC CAGCCCAAGA CTGGTACCTC
CTTGATGATG ACCCAAGACT GCTCACTCTA AGTGCCTCTT CCAAGGTGCC TGTCACCTTG
GCCGCTGTCTT AA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001005915.1
CDS194..745
Misc Feature(1)137..139(+)
Misc Feature(2)359..>613(+)
Exon (1)1..275
Gene:ERBB3
Gene Synonym:
Exon (2)276..427
Gene:ERBB3
Gene Synonym:
Exon (3)428..1050
Gene:ERBB3
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, t dbSNP:113949839
3 3 -, a dbSNP:758493433
41 41 c, g dbSNP:374443471
75 75 c, t dbSNP:568978172
82 82 c, t dbSNP:758462871
136 136 c, t dbSNP:533262937
144 144 c, g dbSNP:376536781
148 148 -, c dbSNP:759985332
155 155 a, g dbSNP:368991808
156 156 a, c dbSNP:373287161
165 165 c, g dbSNP:376595441
173 173 c, g, t dbSNP:759686993
176 176 g, t dbSNP:752771982
180 180 c, t dbSNP:762991374
181 181 c, g dbSNP:369524865
182 182 c, g, t dbSNP:373016496
189 189 a, g dbSNP:572862632
209 209 a, g dbSNP:757100419
221 221 a, c dbSNP:767359947
226 226 a, c dbSNP:750252178
242 242 a, g dbSNP:755757062
245 245 a, c dbSNP:779598315
248 248 a, g dbSNP:748811895
252 252 a, c, t dbSNP:34379766
252 252 -, c dbSNP:768059072
254 254 a, g dbSNP:778250041
271 271 a, g dbSNP:190034531
272 272 a, g dbSNP:771442726
277 277 a, g dbSNP:747687493
278 278 c, t dbSNP:757712749
282 282 c, t dbSNP:56017157
283 283 c, t dbSNP:746211618
290 290 c, t dbSNP:770120793
292 292 a, g dbSNP:775764667
308 308 a, g dbSNP:750029748
310 310 c, g, t dbSNP:749408634
311 311 a, g dbSNP:774536437
313 313 a, c, t dbSNP:762010415
314 314 a, g dbSNP:374953448
317 317 a, g dbSNP:760515344
320 320 a, g dbSNP:766147426
331 331 c, t dbSNP:753681468
336 336 c, t dbSNP:759044259
337 337 a, g dbSNP:764891356
339 339 -, tg dbSNP:764925612
351 351 a, g dbSNP:752180033
353 353 a, g dbSNP:757941835
356 356 a, t dbSNP:781661153
365 365 a, g dbSNP:750947241
367 367 a, g dbSNP:756656037
368 368 a, g dbSNP:780212356
374 374 a, g dbSNP:749691155
376 376 a, g dbSNP:552030360
387 387 c, t dbSNP:779330902
394 394 c, t dbSNP:748210428
396 396 c, t dbSNP:142735651
397 397 g, t dbSNP:760399408
403 403 a, c dbSNP:773189933
408 408 a, c dbSNP:570614098
409 409 c, t dbSNP:765693205
410 410 a, g, t dbSNP:143770796
424 424 a, g dbSNP:199806001
440 440 a, g dbSNP:748439445
442 442 g, t dbSNP:772436902
447 447 c, g dbSNP:777650340
451 451 c, t dbSNP:201378576
457 457 c, t dbSNP:770750571
458 458 a, g dbSNP:77228285
461 461 g, t dbSNP:759321206
473 473 a, g, t dbSNP:769634421
475 475 c, t dbSNP:762522193
479 479 a, g dbSNP:200856864
487 487 a, g dbSNP:773682670
488 488 c, t dbSNP:761437304
495 495 a, g, t dbSNP:201479792
496 496 c, t dbSNP:755384403
497 497 c, t dbSNP:765639633
499 499 a, c dbSNP:142358877
500 500 c, t dbSNP:146486757
501 501 a, g dbSNP:778104039
502 502 c, t dbSNP:747026534
507 507 g, t dbSNP:984896
508 508 a, g dbSNP:185577186
509 509 c, t dbSNP:757425458
510 510 a, g dbSNP:780976894
526 526 c, t dbSNP:745744610
528 528 a, g dbSNP:769723853
530 530 c, g dbSNP:375644422
547 547 c, t dbSNP:775223707
548 548 a, g dbSNP:759113437
552 552 c, t dbSNP:749101304
561 561 a, g dbSNP:768175062
580 580 c, t dbSNP:774095251
584 584 c, t dbSNP:761229179
587 587 c, t dbSNP:569206705
591 591 a, c dbSNP:540018426
593 593 c, t dbSNP:772863490
596 596 c, t dbSNP:760053751
597 597 a, g dbSNP:765878149
607 607 a, g dbSNP:369698449
613 613 c, t dbSNP:373473538
614 614 a, g dbSNP:764216267
620 620 c, t dbSNP:751866833
624 624 c, t dbSNP:757433330
625 625 a, g dbSNP:781263660
645 645 c, t dbSNP:745974664
648 648 c, t dbSNP:755994398
651 651 a, c dbSNP:780012513
652 652 a, g dbSNP:537427649
657 657 c, t dbSNP:199586304
660 660 a, g dbSNP:368815108
671 671 c, t dbSNP:773866522
674 674 c, t dbSNP:747781332
683 683 a, g dbSNP:771629308
686 686 c, g dbSNP:772810438
689 689 a, g dbSNP:760284985
694 694 a, g dbSNP:770391904
699 699 c, t dbSNP:776203562
701 701 c, t dbSNP:763214247
703 703 a, c dbSNP:552306307
707 707 a, g dbSNP:751870363
708 708 c, t dbSNP:762050460
719 719 g, t dbSNP:767745935
733 733 c, g dbSNP:750476308
737 737 a, g dbSNP:188955993
740 740 a, g dbSNP:779965253
743 743 g, t dbSNP:372736362
755 755 g, t dbSNP:534803783
757 757 c, t dbSNP:553090262
762 762 a, c dbSNP:747927084
768 768 c, t dbSNP:771709447
774 774 a, c, g dbSNP:548496368
779 779 -, cagt dbSNP:754936669
779 779 a, c dbSNP:559937373
782 782 c, t dbSNP:776293588
785 785 a, g dbSNP:763449522
850 850 c, t dbSNP:552597623
863 863 c, t dbSNP:79581177
892 892 c, t dbSNP:148655905
893 893 a, g dbSNP:548907427
900 900 a, g dbSNP:775133016
906 906 a, g dbSNP:545742674
1024 1024 a, g dbSNP:557470204

Target ORF information:

RefSeq Version NM_001005915
Organism Homo sapiens (human)
Definition Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant s, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001005915

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAGGGCGA ACGACGCTCT GCAGGTGCTG GGCTTGCTTT TCAGCCTGGC CCGGGGCTCC 
GAGGTGGGCA ACTCTCAGGC AGTGTGTCCT GGGACTCTGA ATGGCCTGAG TGTGACCGGC
GATGCTGAGA ACCAATACCA GACACTGTAC AAGCTCTACG AGAGGTGTGA GGTGGTGATG
GGGAACCTTG AGATTGTGCT CACGGGACAC AATGCCGACC TCTCCTTCCT GCAGTGGATT
CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAATGAAT TCTCTACTCT ACCATTGCCC
AACCTCCGCG TGGTGCGAGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTCGTCATG
TTGAACTATA ACACCAACTC CAGCCACGCT CTGCGCCAGC TCCGCTTGAC TCAGCTCACC
GGTCAGTTCC CGATGGTTCC TTCTGGCCTC ACCCCTCAGC CAGCCCAAGA CTGGTACCTC
CTTGATGATG ACCCAAGACT GCTCACTCTA AGTGCCTCTT CCAAGGTGCC TGTCACCTTG
GCCGCTGTCTT AA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.