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ESR2 estrogen receptor 2 (ER beta) [Homo sapiens (human)]

Gene Symbol ESR2
Entrez Gene ID 2100
Full Name estrogen receptor 2 (ER beta)
Synonyms ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
General protein information
Preferred Names
estrogen receptor beta
Names
estrogen receptor beta
estrogen receptor beta 4
estrogen nuclear receptor beta variant a
estrogen nuclear receptor beta variant b
nuclear receptor subfamily 3 group A member 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q23.2

Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601663

Disorder Html:





The following ESR2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ESR2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu57581 XM_011536545 PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $439
OHu25562 XM_011536546 PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$307.3
$439
OHu22338 NM_001214902 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant d, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu22461 NM_001271876 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant f, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu23139 NM_001271877 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant g, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu23506 NM_001291712 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant k, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.3
$319
OHu25562 NM_001437 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$307.3
$439
OHu23506 NM_001040275 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.3
$319
OHu23506 NM_001291723 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant l, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.3
$319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu57581
Accession Version XM_011536545.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1623bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product estrogen receptor beta isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_026437.13) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGGAGA CAAAGTGTGG GCATTTTTCC AAAATGGGAG
CTGATAAACA TCAACAGAGC ATCACTAATT TACAAAGGCA TTTCTGAGAA GCCTGAAGAT
CACCCATACC CAAAGGAGGA AAGCCAAATG CACCCTCAGG AGCAGCACAC AAATAAGAGA
AACAGCAACT GGACCACAGG CACTCCACGT GCATCTCTCC AACATATTGT GCTGCGCAAA
TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011534847.1
CDS538..2160
Misc Feature(1)598..909(+)
Misc Feature(2)967..1212(+)
Misc Feature(3)982..1149(+)
Misc Feature(4)1009..1152(+)
Misc Feature(5)1087..1137(+)
Misc Feature(6)1324..1941(+)
Misc Feature(7)1429..1575(+)
Misc Feature(8)1465..1533(+)
Misc Feature(9)1744..1938(+)
Translation
Position Chain Variation Link
30 30 c, g dbSNP:777311693
56 56 c, t dbSNP:147604405
64 64 c, t dbSNP:549397346
72 72 c, g dbSNP:145304885
77 77 g, t dbSNP:35036378
88 88 g, t dbSNP:766797386
92 92 -, aagg dbSNP:144533879
129 129 c, t dbSNP:756601291
134 134 a, g dbSNP:375468181
159 159 a, c dbSNP:544752773
186 186 a, g dbSNP:527334187
194 194 c, t dbSNP:757409225
222 222 a, g dbSNP:750982027
236 236 g, t dbSNP:111572677
252 252 c, g dbSNP:763849389
302 302 a, c dbSNP:113832870
307 307 g, t dbSNP:546036025
322 322 g, t dbSNP:767557773
333 333 c, t dbSNP:577167636
365 365 g, t dbSNP:147844441
380 380 c, t dbSNP:557297941
383 383 c, g, t dbSNP:537439799
384 384 -, c, cc dbSNP:3832949
384 384 c, g dbSNP:764224568
450 450 a, g dbSNP:752998368
463 463 a, g dbSNP:140514427
465 465 a, g dbSNP:779390544
479 479 a, g dbSNP:186173828
486 486 c, t dbSNP:772255075
487 487 a, g dbSNP:746385847
488 488 a, g dbSNP:774892627
489 489 a, c dbSNP:374747596
490 490 c, g dbSNP:747695780
491 491 g, t dbSNP:780545357
497 497 a, c dbSNP:544267958
501 501 c, t dbSNP:746603320
508 508 a, g dbSNP:779905252
509 509 a, c, g dbSNP:750231632
524 524 c, t dbSNP:765335664
530 530 -, gaatg dbSNP:770398805
530 530 a, c, t dbSNP:754023746
535 535 g, t dbSNP:754382190
536 536 a, t dbSNP:764034141
538 538 a, g dbSNP:760953580
542 542 a, g dbSNP:752802126
544 544 a, g dbSNP:111918185
553 553 g, t dbSNP:759956733
554 554 c, t dbSNP:774665914
556 556 c, t dbSNP:578240507
563 563 g, t dbSNP:771475824
572 572 c, g dbSNP:763399801
582 582 c, t dbSNP:146774535
584 584 a, g dbSNP:767986827
587 587 a, g dbSNP:746690121
596 596 -, aatccatc dbSNP:748819718
597 597 a, g dbSNP:371185098
601 601 a, g, t dbSNP:76299711
602 602 c, t dbSNP:778833916
613 613 g, t dbSNP:757286052
617 617 -, acggc dbSNP:772916512
617 617 a, g dbSNP:753680835
618 618 c, t dbSNP:145033525
619 619 a, g dbSNP:181439439
625 625 a, g dbSNP:750603094
629 629 -, ta dbSNP:139951512
631 631 a, g dbSNP:752813103
632 632 c, t dbSNP:767669644
633 633 a, t dbSNP:759731803
634 634 c, t dbSNP:751944011
643 643 g, t dbSNP:766687268
646 646 a, g dbSNP:61760170
654 654 a, c dbSNP:773535672
655 655 a, c, t dbSNP:577163101
665 665 a, g dbSNP:775038176
677 677 c, t dbSNP:771904224
681 681 c, g dbSNP:745470989
683 683 a, g dbSNP:778885246
687 687 c, t dbSNP:557221858
688 688 c, t dbSNP:749093040
689 689 c, t dbSNP:777634220
698 698 g, t dbSNP:558493944
701 701 a, c dbSNP:752767552
717 717 c, g dbSNP:781199121
719 719 a, g dbSNP:200128566
720 720 c, t dbSNP:751713041
736 736 a, g dbSNP:376782264
737 737 a, g dbSNP:758750077
742 742 c, g dbSNP:373249723
748 748 c, t dbSNP:750795212
749 749 a, g dbSNP:765704047
766 766 a, c dbSNP:762362679
769 769 g, t dbSNP:774889601
773 773 c, t dbSNP:61760171
789 789 a, g dbSNP:762164271
807 807 g, t dbSNP:199868673
814 814 c, t dbSNP:147382781
815 815 a, g dbSNP:142737037
819 819 c, g dbSNP:770698509
827 827 a, g dbSNP:199565279
829 829 c, t dbSNP:139503857
835 835 a, g dbSNP:568366119
836 836 c, t dbSNP:769639263
837 837 a, g dbSNP:150887025
864 864 a, c dbSNP:781253938
872 872 a, c, t dbSNP:141516067
877 877 a, g dbSNP:780323597
892 892 a, g dbSNP:148388530
897 897 c, g, t dbSNP:765590594
901 901 c, g dbSNP:751133775
903 903 a, c, g dbSNP:370669059
906 906 a, c dbSNP:142771803
909 909 c, g dbSNP:775813046
912 912 a, g dbSNP:764783863
919 919 a, g dbSNP:761663618
921 921 c, t dbSNP:138182239
927 927 a, g dbSNP:768631700
929 929 a, g dbSNP:760559822
931 931 c, g dbSNP:145711407
932 932 a, g dbSNP:200062531
933 933 c, t dbSNP:746096082
936 936 c, t dbSNP:140630557
937 937 a, g dbSNP:774742997
942 942 c, t dbSNP:749716786
947 947 c, t dbSNP:778231084
952 952 a, g dbSNP:756718563
957 957 a, g dbSNP:145757800
962 962 c, t dbSNP:779443173
965 965 a, g dbSNP:757984082
969 969 a, g dbSNP:150153463
984 984 c, t dbSNP:749898001
985 985 a, g, t dbSNP:761435805
990 990 c, t dbSNP:753657562
996 996 c, t dbSNP:763840228
997 997 a, g dbSNP:760612953
998 998 a, g dbSNP:775445438
1001 1001 a, g dbSNP:771893373
1002 1002 c, t dbSNP:200625141
1005 1005 a, t dbSNP:1541060
1008 1008 a, g dbSNP:150534198
1011 1011 a, c dbSNP:749478587
1014 1014 c, t dbSNP:373386845
1019 1019 a, g dbSNP:770224156
1023 1023 a, g dbSNP:748510590
1031 1031 c, t dbSNP:141760704
1032 1032 a, g dbSNP:151012840
1041 1041 a, t dbSNP:745433371
1047 1047 a, g dbSNP:778238323
1062 1062 a, g dbSNP:369907593
1074 1074 a, g dbSNP:752555445
1075 1075 c, t dbSNP:770100746
1078 1078 -, aat dbSNP:750091675
1087 1087 a, c dbSNP:767173223
1097 1097 c, g dbSNP:754945292
1106 1106 a, g dbSNP:552876311
1107 1107 a, g dbSNP:751392863
1108 1108 g, t dbSNP:766405281
1110 1110 c, t dbSNP:763191319
1112 1112 c, t dbSNP:369253565
1115 1115 a, t dbSNP:773394073
1116 1116 c, t dbSNP:374870812
1117 1117 a, g dbSNP:145278854
1119 1119 c, t dbSNP:139479509
1123 1123 a, g dbSNP:761893224
1126 1126 a, c dbSNP:760053106
1127 1127 a, g dbSNP:539747077
1129 1129 c, t dbSNP:768839285
1146 1146 a, c dbSNP:761261331
1149 1149 c, t dbSNP:776039661
1150 1150 c, t dbSNP:772568096
1151 1151 a, g dbSNP:748841139
1156 1156 c, t dbSNP:371856990
1157 1157 a, g dbSNP:368924653
1165 1165 c, t dbSNP:747686242
1166 1166 a, g dbSNP:781052752
1167 1167 c, g, t dbSNP:2228481
1168 1168 a, g dbSNP:556956556
1170 1170 a, g dbSNP:74808355
1182 1182 g, t dbSNP:750554682
1184 1184 a, c dbSNP:765370070
1186 1186 c, t dbSNP:762101051
1197 1197 a, c, g dbSNP:774894727
1198 1198 a, g dbSNP:78851986
1203 1203 a, g dbSNP:761268108
1206 1206 -, ga dbSNP:764429735
1206 1206 a, g dbSNP:776182715
1212 1212 a, g dbSNP:113888207
1215 1215 c, g dbSNP:746620276
1218 1218 c, t dbSNP:775430518
1219 1219 c, t dbSNP:530072718
1220 1220 a, c, t dbSNP:561226739
1221 1221 c, t dbSNP:757190866
1222 1222 a, g dbSNP:145387917
1223 1223 a, c, g, t dbSNP:199669101
1225 1225 a, c dbSNP:200629827
1226 1226 a, g dbSNP:752856261
1230 1230 a, g dbSNP:767711085
1235 1235 c, g dbSNP:200990124
1242 1242 c, t dbSNP:368036749
1243 1243 c, g dbSNP:755401425
1245 1245 c, t dbSNP:751889019
1246 1246 a, g dbSNP:766843910
1248 1248 a, g dbSNP:763467918
1260 1260 c, t dbSNP:776036845
1262 1262 c, t dbSNP:763594392
1265 1265 a, g dbSNP:760419460
1267 1267 a, g dbSNP:576722274
1273 1273 a, g dbSNP:775342550
1284 1284 c, t dbSNP:771849161
1285 1285 a, c, g dbSNP:201239439
1290 1290 c, t dbSNP:770801445
1291 1291 a, g dbSNP:543025691
1292 1292 a, c, t dbSNP:370979619
1293 1293 -, g dbSNP:753146864
1294 1294 c, g dbSNP:748219656
1295 1295 c, t dbSNP:781431063
1296 1296 c, g dbSNP:755168876
1300 1300 c, g dbSNP:751892376
1304 1304 c, g dbSNP:202146084
1309 1309 c, t dbSNP:143949374
1318 1318 a, g dbSNP:758834110
1320 1320 c, t dbSNP:750886730
1321 1321 g, t dbSNP:765827699
1329 1329 a, c dbSNP:760331553
1332 1332 -, c dbSNP:759924525
1332 1332 c, t dbSNP:554390029
1335 1335 a, g dbSNP:767333417
1338 1338 g, t dbSNP:149404315
1339 1339 c, t dbSNP:774048787
1342 1342 a, g dbSNP:770714265
1344 1344 c, g dbSNP:762636828
1345 1345 c, t dbSNP:139838202
1349 1349 a, c, t dbSNP:748286878
1358 1358 a, t dbSNP:781190983
1367 1367 a, c dbSNP:768870975
1368 1368 a, g dbSNP:747213970
1371 1371 c, t dbSNP:780304063
1377 1377 a, g dbSNP:769393357
1380 1380 g, t dbSNP:758845568
1381 1381 a, g dbSNP:750720041
1383 1383 a, c, t dbSNP:757821946
1387 1387 c, t dbSNP:752264246
1390 1390 c, t dbSNP:767100418
1403 1403 a, t dbSNP:759137869
1408 1408 a, g dbSNP:751277839
1410 1410 a, g dbSNP:527718361
1411 1411 a, g dbSNP:765919886
1417 1417 a, g dbSNP:762875795
1425 1425 a, g dbSNP:559087939
1434 1434 c, t dbSNP:769738063
1438 1438 c, g, t dbSNP:747372616
1440 1440 a, g dbSNP:776723904
1441 1441 g, t dbSNP:768672906
1444 1444 g, t dbSNP:747036560
1448 1448 a, c, t dbSNP:539389612
1452 1452 a, g dbSNP:746299554
1462 1462 a, g dbSNP:779359374
1468 1468 a, g, t dbSNP:201349732
1473 1473 g, t dbSNP:550448628
1486 1486 a, c, t dbSNP:138920605
1488 1488 -, c dbSNP:774779393
1491 1491 c, t dbSNP:777043910
1496 1496 g, t dbSNP:769145181
1497 1497 a, g dbSNP:745438689
1504 1504 a, g dbSNP:778333818
1506 1506 c, t dbSNP:145690231
1508 1508 g, t dbSNP:748895913
1509 1509 g, t dbSNP:777642861
1512 1512 c, g, t dbSNP:58256696
1521 1521 a, g dbSNP:1256049
1522 1522 a, c, t dbSNP:575267235
1523 1523 a, g dbSNP:145661652
1524 1524 a, g dbSNP:766529045
1527 1527 c, g dbSNP:141414270
1529 1529 -, t dbSNP:762454979
1534 1534 a, g dbSNP:750660776
1539 1539 c, t dbSNP:56926155
1540 1540 c, t dbSNP:149090049
1548 1548 a, g dbSNP:144986202
1553 1553 g, t dbSNP:769163374
1554 1554 a, c dbSNP:573246090
1557 1557 a, g dbSNP:146977918
1562 1562 a, g dbSNP:553390407
1573 1573 c, t dbSNP:200264592
1578 1578 a, c dbSNP:770374094
1579 1579 a, g dbSNP:372274623
1580 1580 c, t dbSNP:758311034
1588 1588 c, t dbSNP:769476765
1590 1590 c, t dbSNP:747912769
1591 1591 a, g dbSNP:368060197
1593 1593 a, c dbSNP:754998201
1595 1595 a, t dbSNP:752612054
1621 1621 c, g dbSNP:550575939
1629 1629 g, t dbSNP:141474553
1638 1638 a, g dbSNP:147847668
1639 1639 a, g dbSNP:144249047
1644 1644 c, g, t dbSNP:80118085
1645 1645 a, g dbSNP:745947456
1658 1658 g, t dbSNP:778982958
1665 1665 c, t dbSNP:531227990
1671 1671 c, t dbSNP:376348920
1672 1672 a, g dbSNP:754008155
1677 1677 c, g dbSNP:374768593
1679 1679 c, t dbSNP:112017626
1685 1685 a, c dbSNP:764274252
1687 1687 a, g dbSNP:756507443
1688 1688 c, t dbSNP:753050523
1692 1692 a, g dbSNP:768030327
1695 1695 g, t dbSNP:760024678
1699 1699 c, t dbSNP:772629994
1700 1700 a, g dbSNP:764756707
1713 1713 c, g dbSNP:1256054
1717 1717 c, t dbSNP:776464052
1719 1719 c, g dbSNP:768417560
1725 1725 a, g dbSNP:45624541
1737 1737 c, g dbSNP:775365033
1743 1743 -, tc dbSNP:746812518
1743 1743 c, g dbSNP:72548752
1744 1744 a, g dbSNP:771907276
1746 1746 g, t dbSNP:79216673
1752 1752 g, t dbSNP:778878210
1753 1753 c, g, t dbSNP:373170989
1754 1754 c, g, t dbSNP:111471356
1756 1756 a, t dbSNP:778031158
1760 1760 c, t dbSNP:78255744
1761 1761 c, t dbSNP:753066940
1765 1765 a, g dbSNP:753401843
1774 1774 c, g dbSNP:2229618
1783 1783 -, g dbSNP:34624204
1793 1793 a, g, t dbSNP:752438967
1796 1796 c, t dbSNP:767044157
1800 1800 c, t dbSNP:759440360
1801 1801 a, g dbSNP:773962693
1805 1805 a, g dbSNP:770908423
1807 1807 c, t dbSNP:142544449
1808 1808 a, g dbSNP:773306825
1810 1810 a, g dbSNP:371686799
1812 1812 a, g dbSNP:369993150
1817 1817 c, t dbSNP:146717881
1826 1826 a, t dbSNP:755668062
1827 1827 c, g dbSNP:768749310
1831 1831 a, g dbSNP:377196538
1832 1832 a, c dbSNP:211694397
1833 1833 c, t dbSNP:148775627
1834 1834 a, g dbSNP:200615874
1838 1838 c, t dbSNP:565419607
1839 1839 c, t dbSNP:368248753
1843 1843 a, g dbSNP:779536246
1854 1854 g, t dbSNP:113652563
1855 1855 a, g, t dbSNP:370716868
1860 1860 c, t dbSNP:60101369
1861 1861 a, g dbSNP:754524028
1865 1865 a, g dbSNP:751404448
1868 1868 a, g dbSNP:367855747
1869 1869 c, t dbSNP:144392940
1870 1870 a, g dbSNP:773174281
1878 1878 a, c dbSNP:765157926
1887 1887 a, g dbSNP:761939611
1888 1888 a, c dbSNP:776514667
1897 1897 c, t dbSNP:768924970
1898 1898 a, g dbSNP:139785869
1901 1901 c, t dbSNP:775944471
1902 1902 a, g dbSNP:772610168
1904 1904 c, t dbSNP:746200870
1910 1910 a, t dbSNP:146380568
1917 1917 g, t dbSNP:757823564
1918 1918 a, c dbSNP:747701419
1920 1920 c, g dbSNP:780531016
1921 1921 c, t dbSNP:754686565
1922 1922 c, t dbSNP:375446581
1926 1926 c, t dbSNP:765985203
1929 1929 a, c, t dbSNP:543310306
1930 1930 a, g dbSNP:777286766
1937 1937 a, g dbSNP:765174403
1938 1938 c, g, t dbSNP:776801399
1940 1940 c, t dbSNP:764031807
1941 1941 a, g dbSNP:370033234
1945 1945 -, a dbSNP:549375992
1959 1959 a, c dbSNP:564506805
1964 1964 a, t dbSNP:747199272
1981 1981 a, t dbSNP:773370117
2010 2010 c, t dbSNP:544811509
2015 2015 c, g dbSNP:536165319
2019 2019 g, t dbSNP:747904901
2056 2056 a, g dbSNP:778872622
2076 2076 a, g dbSNP:145628567
2100 2100 a, c dbSNP:183540086
2130 2130 a, c dbSNP:572897686
2146 2146 g, t dbSNP:549908035
2153 2153 a, g dbSNP:7147022
2204 2204 -, ct dbSNP:776877224
2322 2322 c, t dbSNP:61987297
2366 2366 a, g dbSNP:191522698
2382 2382 a, g dbSNP:374498855
2388 2388 c, t dbSNP:776161784
2406 2406 c, t dbSNP:189174615
2407 2407 a, g dbSNP:140630558
2455 2455 c, t dbSNP:549105091
2466 2466 g, t dbSNP:372875361
2475 2475 g, t dbSNP:566467126
2477 2477 a, c dbSNP:76432029
2487 2487 a, g dbSNP:533152556
2491 2491 c, t dbSNP:780721335
2542 2542 g, t dbSNP:551139330
2555 2555 -, t dbSNP:11369182
2568 2568 -, t dbSNP:111982316
2569 2569 -, t dbSNP:201610379
2569 2569 c, t dbSNP:28367065
2570 2570 -, c dbSNP:779278020

Target ORF information:

RefSeq Version XM_011536545
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011536545

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGGAGA CAAAGTGTGG GCATTTTTCC AAAATGGGAG
CTGATAAACA TCAACAGAGC ATCACTAATT TACAAAGGCA TTTCTGAGAA GCCTGAAGAT
CACCCATACC CAAAGGAGGA AAGCCAAATG CACCCTCAGG AGCAGCACAC AAATAAGAGA
AACAGCAACT GGACCACAGG CACTCCACGT GCATCTCTCC AACATATTGT GCTGCGCAAA
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25562
Accession Version XM_011536546.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1593bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product estrogen receptor beta isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_026437.13) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGTAAC AAGGGCATGG AACATCTGCT CAACATGAAG
TGCAAAAATG TGGTCCCAGT GTATGACCTG CTGCTGGAGA TGCTGAATGC CCACGTGCTT
CGCGGGTGCA AGTCCTCCAT CACGGGGTCC GAGTGCAGCC CGGCAGAGGA CAGTAAAAGC
AAAGAGGGCT CCCAGAACCC ACAGTCTCAG TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011534848.1
CDS1039..2631
Misc Feature(1)1099..1410(+)
Misc Feature(2)1468..1713(+)
Misc Feature(3)1483..1650(+)
Misc Feature(4)1510..1653(+)
Misc Feature(5)1588..1638(+)
Misc Feature(6)1825..2532(+)
Misc Feature(7)1930..2463(+)
Misc Feature(8)1966..2520(+)
Misc Feature(9)2245..2448(+)
Translation
Position Chain Variation Link
3 3 c, t dbSNP:551142036
20 20 c, t dbSNP:531011580
91 91 c, g dbSNP:17226088
149 149 c, g dbSNP:548625285
175 175 g, t dbSNP:771202993
179 179 c, t dbSNP:145013131
231 231 a, c dbSNP:149938423
281 281 c, t dbSNP:746721650
293 293 g, t dbSNP:560881571
304 304 a, g dbSNP:540162172
331 331 c, t dbSNP:375016427
336 336 a, c dbSNP:533044966
351 351 -, tg dbSNP:372284435
354 354 -, gt dbSNP:138879712
377 377 -, aact dbSNP:751800402
381 381 -, gt dbSNP:778100455
457 457 g, t dbSNP:745768806
464 464 a, c dbSNP:143284927
530 530 -, a dbSNP:746729811
593 593 a, g dbSNP:142232928
613 613 a, c dbSNP:758823826
620 620 a, c dbSNP:753303275
624 624 a, c dbSNP:779116174
640 640 c, g dbSNP:532411612
669 669 g, t dbSNP:570041579
674 674 a, g dbSNP:184217696
684 684 a, c dbSNP:755151422
687 687 c, t dbSNP:377369697
691 691 a, g dbSNP:561190072
710 710 a, g dbSNP:749994469
712 712 a, g dbSNP:72722328
722 722 a, g dbSNP:754077067
725 725 c, g dbSNP:531407954
782 782 a, g dbSNP:569762186
811 811 a, g dbSNP:759086778
826 826 -, a dbSNP:577266240
854 854 a, c, g dbSNP:35142532
872 872 a, g dbSNP:748572453
913 913 a, c dbSNP:529966631
930 930 c, t dbSNP:774945468
951 951 a, g dbSNP:752998368
964 964 a, g dbSNP:140514427
966 966 a, g dbSNP:779390544
980 980 a, g dbSNP:186173828
987 987 c, t dbSNP:772255075
988 988 a, g dbSNP:746385847
989 989 a, g dbSNP:774892627
990 990 a, c dbSNP:374747596
991 991 c, g dbSNP:747695780
992 992 g, t dbSNP:780545357
998 998 a, c dbSNP:544267958
1002 1002 c, t dbSNP:746603320
1009 1009 a, g dbSNP:779905252
1010 1010 a, c, g dbSNP:750231632
1025 1025 c, t dbSNP:765335664
1031 1031 -, gaatg dbSNP:770398805
1031 1031 a, c, t dbSNP:754023746
1036 1036 g, t dbSNP:754382190
1037 1037 a, t dbSNP:764034141
1039 1039 a, g dbSNP:760953580
1043 1043 a, g dbSNP:752802126
1045 1045 a, g dbSNP:111918185
1054 1054 g, t dbSNP:759956733
1055 1055 c, t dbSNP:774665914
1057 1057 c, t dbSNP:578240507
1064 1064 g, t dbSNP:771475824
1073 1073 c, g dbSNP:763399801
1083 1083 c, t dbSNP:146774535
1085 1085 a, g dbSNP:767986827
1088 1088 a, g dbSNP:746690121
1097 1097 -, aatccatc dbSNP:748819718
1098 1098 a, g dbSNP:371185098
1102 1102 a, g, t dbSNP:76299711
1103 1103 c, t dbSNP:778833916
1114 1114 g, t dbSNP:757286052
1118 1118 -, acggc dbSNP:772916512
1118 1118 a, g dbSNP:753680835
1119 1119 c, t dbSNP:145033525
1120 1120 a, g dbSNP:181439439
1126 1126 a, g dbSNP:750603094
1130 1130 -, ta dbSNP:139951512
1132 1132 a, g dbSNP:752813103
1133 1133 c, t dbSNP:767669644
1134 1134 a, t dbSNP:759731803
1135 1135 c, t dbSNP:751944011
1144 1144 g, t dbSNP:766687268
1147 1147 a, g dbSNP:61760170
1155 1155 a, c dbSNP:773535672
1156 1156 a, c, t dbSNP:577163101
1166 1166 a, g dbSNP:775038176
1178 1178 c, t dbSNP:771904224
1182 1182 c, g dbSNP:745470989
1184 1184 a, g dbSNP:778885246
1188 1188 c, t dbSNP:557221858
1189 1189 c, t dbSNP:749093040
1190 1190 c, t dbSNP:777634220
1199 1199 g, t dbSNP:558493944
1202 1202 a, c dbSNP:752767552
1218 1218 c, g dbSNP:781199121
1220 1220 a, g dbSNP:200128566
1221 1221 c, t dbSNP:751713041
1237 1237 a, g dbSNP:376782264
1238 1238 a, g dbSNP:758750077
1243 1243 c, g dbSNP:373249723
1249 1249 c, t dbSNP:750795212
1250 1250 a, g dbSNP:765704047
1267 1267 a, c dbSNP:762362679
1270 1270 g, t dbSNP:774889601
1274 1274 c, t dbSNP:61760171
1290 1290 a, g dbSNP:762164271
1308 1308 g, t dbSNP:199868673
1315 1315 c, t dbSNP:147382781
1316 1316 a, g dbSNP:142737037
1320 1320 c, g dbSNP:770698509
1328 1328 a, g dbSNP:199565279
1330 1330 c, t dbSNP:139503857
1336 1336 a, g dbSNP:568366119
1337 1337 c, t dbSNP:769639263
1338 1338 a, g dbSNP:150887025
1365 1365 a, c dbSNP:781253938
1373 1373 a, c, t dbSNP:141516067
1378 1378 a, g dbSNP:780323597
1393 1393 a, g dbSNP:148388530
1398 1398 c, g, t dbSNP:765590594
1402 1402 c, g dbSNP:751133775
1404 1404 a, c, g dbSNP:370669059
1407 1407 a, c dbSNP:142771803
1410 1410 c, g dbSNP:775813046
1413 1413 a, g dbSNP:764783863
1420 1420 a, g dbSNP:761663618
1422 1422 c, t dbSNP:138182239
1428 1428 a, g dbSNP:768631700
1430 1430 a, g dbSNP:760559822
1432 1432 c, g dbSNP:145711407
1433 1433 a, g dbSNP:200062531
1434 1434 c, t dbSNP:746096082
1437 1437 c, t dbSNP:140630557
1438 1438 a, g dbSNP:774742997
1443 1443 c, t dbSNP:749716786
1448 1448 c, t dbSNP:778231084
1453 1453 a, g dbSNP:756718563
1458 1458 a, g dbSNP:145757800
1463 1463 c, t dbSNP:779443173
1466 1466 a, g dbSNP:757984082
1470 1470 a, g dbSNP:150153463
1485 1485 c, t dbSNP:749898001
1486 1486 a, g, t dbSNP:761435805
1491 1491 c, t dbSNP:753657562
1497 1497 c, t dbSNP:763840228
1498 1498 a, g dbSNP:760612953
1499 1499 a, g dbSNP:775445438
1502 1502 a, g dbSNP:771893373
1503 1503 c, t dbSNP:200625141
1506 1506 a, t dbSNP:1541060
1509 1509 a, g dbSNP:150534198
1512 1512 a, c dbSNP:749478587
1515 1515 c, t dbSNP:373386845
1520 1520 a, g dbSNP:770224156
1524 1524 a, g dbSNP:748510590
1532 1532 c, t dbSNP:141760704
1533 1533 a, g dbSNP:151012840
1542 1542 a, t dbSNP:745433371
1548 1548 a, g dbSNP:778238323
1563 1563 a, g dbSNP:369907593
1575 1575 a, g dbSNP:752555445
1576 1576 c, t dbSNP:770100746
1579 1579 -, aat dbSNP:750091675
1588 1588 a, c dbSNP:767173223
1598 1598 c, g dbSNP:754945292
1607 1607 a, g dbSNP:552876311
1608 1608 a, g dbSNP:751392863
1609 1609 g, t dbSNP:766405281
1611 1611 c, t dbSNP:763191319
1613 1613 c, t dbSNP:369253565
1616 1616 a, t dbSNP:773394073
1617 1617 c, t dbSNP:374870812
1618 1618 a, g dbSNP:145278854
1620 1620 c, t dbSNP:139479509
1624 1624 a, g dbSNP:761893224
1627 1627 a, c dbSNP:760053106
1628 1628 a, g dbSNP:539747077
1630 1630 c, t dbSNP:768839285
1647 1647 a, c dbSNP:761261331
1650 1650 c, t dbSNP:776039661
1651 1651 c, t dbSNP:772568096
1652 1652 a, g dbSNP:748841139
1657 1657 c, t dbSNP:371856990
1658 1658 a, g dbSNP:368924653
1666 1666 c, t dbSNP:747686242
1667 1667 a, g dbSNP:781052752
1668 1668 c, g, t dbSNP:2228481
1669 1669 a, g dbSNP:556956556
1671 1671 a, g dbSNP:74808355
1683 1683 g, t dbSNP:750554682
1685 1685 a, c dbSNP:765370070
1687 1687 c, t dbSNP:762101051
1698 1698 a, c, g dbSNP:774894727
1699 1699 a, g dbSNP:78851986
1704 1704 a, g dbSNP:761268108
1707 1707 -, ga dbSNP:764429735
1707 1707 a, g dbSNP:776182715
1713 1713 a, g dbSNP:113888207
1716 1716 c, g dbSNP:746620276
1719 1719 c, t dbSNP:775430518
1720 1720 c, t dbSNP:530072718
1721 1721 a, c, t dbSNP:561226739
1722 1722 c, t dbSNP:757190866
1723 1723 a, g dbSNP:145387917
1724 1724 a, c, g, t dbSNP:199669101
1726 1726 a, c dbSNP:200629827
1727 1727 a, g dbSNP:752856261
1731 1731 a, g dbSNP:767711085
1736 1736 c, g dbSNP:200990124
1743 1743 c, t dbSNP:368036749
1744 1744 c, g dbSNP:755401425
1746 1746 c, t dbSNP:751889019
1747 1747 a, g dbSNP:766843910
1749 1749 a, g dbSNP:763467918
1761 1761 c, t dbSNP:776036845
1763 1763 c, t dbSNP:763594392
1766 1766 a, g dbSNP:760419460
1768 1768 a, g dbSNP:576722274
1774 1774 a, g dbSNP:775342550
1785 1785 c, t dbSNP:771849161
1786 1786 a, c, g dbSNP:201239439
1791 1791 c, t dbSNP:770801445
1792 1792 a, g dbSNP:543025691
1793 1793 a, c, t dbSNP:370979619
1794 1794 -, g dbSNP:753146864
1795 1795 c, g dbSNP:748219656
1796 1796 c, t dbSNP:781431063
1797 1797 c, g dbSNP:755168876
1801 1801 c, g dbSNP:751892376
1805 1805 c, g dbSNP:202146084
1810 1810 c, t dbSNP:143949374
1819 1819 a, g dbSNP:758834110
1821 1821 c, t dbSNP:750886730
1822 1822 g, t dbSNP:765827699
1830 1830 a, c dbSNP:760331553
1833 1833 -, c dbSNP:759924525
1833 1833 c, t dbSNP:554390029
1836 1836 a, g dbSNP:767333417
1839 1839 g, t dbSNP:149404315
1840 1840 c, t dbSNP:774048787
1843 1843 a, g dbSNP:770714265
1845 1845 c, g dbSNP:762636828
1846 1846 c, t dbSNP:139838202
1850 1850 a, c, t dbSNP:748286878
1859 1859 a, t dbSNP:781190983
1868 1868 a, c dbSNP:768870975
1869 1869 a, g dbSNP:747213970
1872 1872 c, t dbSNP:780304063
1878 1878 a, g dbSNP:769393357
1881 1881 g, t dbSNP:758845568
1882 1882 a, g dbSNP:750720041
1884 1884 a, c, t dbSNP:757821946
1888 1888 c, t dbSNP:752264246
1891 1891 c, t dbSNP:767100418
1904 1904 a, t dbSNP:759137869
1909 1909 a, g dbSNP:751277839
1911 1911 a, g dbSNP:527718361
1912 1912 a, g dbSNP:765919886
1918 1918 a, g dbSNP:762875795
1926 1926 a, g dbSNP:559087939
1935 1935 c, t dbSNP:769738063
1939 1939 c, g, t dbSNP:747372616
1941 1941 a, g dbSNP:776723904
1942 1942 g, t dbSNP:768672906
1945 1945 g, t dbSNP:747036560
1949 1949 a, c, t dbSNP:539389612
1953 1953 a, g dbSNP:746299554
1963 1963 a, g dbSNP:779359374
1969 1969 a, g, t dbSNP:201349732
1974 1974 g, t dbSNP:550448628
1987 1987 a, c, t dbSNP:138920605
1989 1989 -, c dbSNP:774779393
1992 1992 c, t dbSNP:777043910
1997 1997 g, t dbSNP:769145181
1998 1998 a, g dbSNP:745438689
2005 2005 a, g dbSNP:778333818
2007 2007 c, t dbSNP:145690231
2009 2009 g, t dbSNP:748895913
2010 2010 g, t dbSNP:777642861
2013 2013 c, g, t dbSNP:58256696
2022 2022 a, g dbSNP:1256049
2023 2023 a, c, t dbSNP:575267235
2024 2024 a, g dbSNP:145661652
2025 2025 a, g dbSNP:766529045
2028 2028 c, g dbSNP:141414270
2030 2030 -, t dbSNP:762454979
2035 2035 a, g dbSNP:750660776
2040 2040 c, t dbSNP:56926155
2041 2041 c, t dbSNP:149090049
2049 2049 a, g dbSNP:144986202
2054 2054 g, t dbSNP:769163374
2055 2055 a, c dbSNP:573246090
2058 2058 a, g dbSNP:146977918
2063 2063 a, g dbSNP:553390407
2074 2074 c, t dbSNP:200264592
2079 2079 a, c dbSNP:770374094
2080 2080 a, g dbSNP:372274623
2081 2081 c, t dbSNP:758311034
2089 2089 c, t dbSNP:769476765
2091 2091 c, t dbSNP:747912769
2092 2092 a, g dbSNP:368060197
2094 2094 a, c dbSNP:754998201
2096 2096 a, t dbSNP:752612054
2122 2122 c, g dbSNP:550575939
2130 2130 g, t dbSNP:141474553
2139 2139 a, g dbSNP:147847668
2140 2140 a, g dbSNP:144249047
2145 2145 c, g, t dbSNP:80118085
2146 2146 a, g dbSNP:745947456
2159 2159 g, t dbSNP:778982958
2166 2166 c, t dbSNP:531227990
2172 2172 c, t dbSNP:376348920
2173 2173 a, g dbSNP:754008155
2178 2178 c, g dbSNP:374768593
2180 2180 c, t dbSNP:112017626
2186 2186 a, c dbSNP:764274252
2188 2188 a, g dbSNP:756507443
2189 2189 c, t dbSNP:753050523
2193 2193 a, g dbSNP:768030327
2196 2196 g, t dbSNP:760024678
2200 2200 c, t dbSNP:772629994
2201 2201 a, g dbSNP:764756707
2214 2214 c, g dbSNP:1256054
2218 2218 c, t dbSNP:776464052
2220 2220 c, g dbSNP:768417560
2226 2226 a, g dbSNP:45624541
2238 2238 c, g dbSNP:775365033
2244 2244 -, tc dbSNP:746812518
2244 2244 c, g dbSNP:72548752
2245 2245 a, g dbSNP:771907276
2247 2247 g, t dbSNP:79216673
2253 2253 g, t dbSNP:778878210
2254 2254 c, g, t dbSNP:373170989
2255 2255 c, g, t dbSNP:111471356
2257 2257 a, t dbSNP:778031158
2261 2261 c, t dbSNP:78255744
2262 2262 c, t dbSNP:753066940
2266 2266 a, g dbSNP:753401843
2275 2275 c, g dbSNP:2229618
2284 2284 -, g dbSNP:34624204
2294 2294 a, g, t dbSNP:752438967
2297 2297 c, t dbSNP:767044157
2301 2301 c, t dbSNP:759440360
2302 2302 a, g dbSNP:773962693
2306 2306 a, g dbSNP:770908423
2308 2308 c, t dbSNP:142544449
2309 2309 a, g dbSNP:773306825
2311 2311 a, g dbSNP:371686799
2313 2313 a, g dbSNP:369993150
2318 2318 c, t dbSNP:146717881
2327 2327 a, t dbSNP:755668062
2328 2328 c, g dbSNP:768749310
2332 2332 a, g dbSNP:377196538
2333 2333 a, c dbSNP:211694397
2334 2334 c, t dbSNP:148775627
2335 2335 a, g dbSNP:200615874
2339 2339 c, t dbSNP:565419607
2340 2340 c, t dbSNP:368248753
2344 2344 a, g dbSNP:779536246
2355 2355 g, t dbSNP:113652563
2356 2356 a, g, t dbSNP:370716868
2361 2361 c, t dbSNP:60101369
2362 2362 a, g dbSNP:754524028
2366 2366 a, g dbSNP:751404448
2369 2369 a, g dbSNP:367855747
2370 2370 c, t dbSNP:144392940
2371 2371 a, g dbSNP:773174281
2379 2379 a, c dbSNP:765157926
2388 2388 a, g dbSNP:761939611
2389 2389 a, c dbSNP:776514667
2398 2398 c, t dbSNP:768924970
2399 2399 a, g dbSNP:139785869
2402 2402 c, t dbSNP:775944471
2403 2403 a, g dbSNP:772610168
2405 2405 c, t dbSNP:746200870
2411 2411 a, t dbSNP:146380568
2418 2418 g, t dbSNP:757823564
2419 2419 a, c dbSNP:747701419
2421 2421 c, g dbSNP:780531016
2422 2422 c, t dbSNP:754686565
2423 2423 c, t dbSNP:375446581
2427 2427 c, t dbSNP:765985203
2430 2430 a, c, t dbSNP:543310306
2431 2431 a, g dbSNP:777286766
2438 2438 a, g dbSNP:765174403
2439 2439 c, g, t dbSNP:776801399
2441 2441 c, t dbSNP:764031807
2442 2442 a, g dbSNP:370033234
2451 2451 a, g dbSNP:752826189
2459 2459 a, g dbSNP:767658683
2461 2461 c, t dbSNP:759669003
2462 2462 a, g dbSNP:751875571
2465 2465 a, t dbSNP:374430941
2471 2471 a, g dbSNP:763287137
2487 2487 c, t dbSNP:773568662
2488 2488 a, g dbSNP:765668910
2499 2499 a, g, t dbSNP:772039917
2502 2502 c, t dbSNP:771618763
2506 2506 c, t dbSNP:745350863
2511 2511 g, t dbSNP:773938169
2514 2514 a, g dbSNP:770601599
2520 2520 a, g dbSNP:749047805
2521 2521 a, c, t dbSNP:756030287
2530 2530 c, t dbSNP:560348068
2532 2532 c, t dbSNP:369733925
2533 2533 a, g dbSNP:141940742
2539 2539 c, t dbSNP:528840784
2540 2540 a, g dbSNP:751676149
2542 2542 a, g dbSNP:766524153
2546 2546 a, g dbSNP:188329310
2553 2553 c, t dbSNP:375552642
2555 2555 c, t dbSNP:765586360
2561 2561 c, t dbSNP:149353401
2562 2562 a, g dbSNP:531728197
2564 2564 a, g dbSNP:138689384
2568 2568 c, g, t dbSNP:773850651
2569 2569 a, g dbSNP:770491054
2574 2574 c, t dbSNP:748928216
2579 2579 c, t dbSNP:565210086
2580 2580 a, g dbSNP:374713642
2581 2581 a, g dbSNP:376023274
2583 2583 a, g dbSNP:201044476
2584 2584 a, g dbSNP:781340136
2586 2586 a, g dbSNP:150646898
2600 2600 a, c dbSNP:747065083
2603 2603 a, g dbSNP:199757132
2611 2611 c, t dbSNP:200502775
2613 2613 a, g dbSNP:758569519
2620 2620 -, ca dbSNP:779856508
2621 2621 a, t dbSNP:750705148
2622 2622 a, g dbSNP:112815397
2624 2624 c, t dbSNP:757686092
2625 2625 g, t dbSNP:754184089
2633 2633 a, g dbSNP:200747927
2634 2634 c, g, t dbSNP:367649109
2639 2639 c, t dbSNP:374618716
2644 2644 a, c dbSNP:762341251
2662 2662 a, g dbSNP:772987842
2669 2669 a, g dbSNP:769561814
2670 2670 a, g dbSNP:4986938
2678 2678 c, t dbSNP:148179737
2679 2679 a, g dbSNP:768747695
2683 2683 a, g dbSNP:535832331
2688 2688 a, g dbSNP:111531403
2694 2694 g, t dbSNP:553565492
2717 2717 c, g dbSNP:534158918
2722 2722 c, g dbSNP:571500085
2766 2766 c, t dbSNP:543245318
2798 2798 a, g dbSNP:778510816
2805 2805 a, g dbSNP:183618483
2835 2835 -, gg dbSNP:139042995
2847 2847 c, g dbSNP:754550908
2851 2851 c, t dbSNP:538154412
2865 2865 a, g dbSNP:569412030
2876 2876 a, g dbSNP:781349834
2884 2884 g, t dbSNP:529570917
2920 2920 -, ct dbSNP:71444647
2985 2985 c, t dbSNP:752035108
2987 2987 a, g dbSNP:764663011
3009 3009 a, g dbSNP:549376508
3023 3023 -, g dbSNP:765911654
3036 3036 g, t dbSNP:8006145
3054 3054 c, t dbSNP:566254425
3065 3065 a, g dbSNP:560661287
3067 3067 c, t dbSNP:546761177
3084 3084 c, t dbSNP:527520283
3095 3095 c, t dbSNP:752669387
3097 3097 c, t dbSNP:540666851
3099 3099 c, g dbSNP:765389927
3105 3105 c, t dbSNP:374468752
3120 3120 a, g dbSNP:143794525
3124 3124 c, t dbSNP:149036359
3128 3128 a, g dbSNP:944459
3134 3134 a, g dbSNP:554830032
3149 3149 a, g dbSNP:562605925
3155 3155 a, t dbSNP:35743760
3170 3170 a, g dbSNP:146413257
3173 3173 a, c dbSNP:553874239
3177 3177 g, t dbSNP:539938573
3272 3272 c, t dbSNP:192958119
3296 3296 a, g dbSNP:760433168
3303 3303 c, t dbSNP:187851763
3323 3323 a, g dbSNP:201591914
3340 3340 c, t dbSNP:538017233
3345 3345 c, t dbSNP:771951851
3349 3349 a, g dbSNP:111964431
3358 3358 a, g dbSNP:569553828
3362 3362 a, c dbSNP:555760010
3377 3377 a, g dbSNP:535875435
3421 3421 a, g dbSNP:748119265
3434 3434 c, t dbSNP:545050577
3435 3435 a, g dbSNP:566740935
3474 3474 -, tgggtg dbSNP:536195897
3476 3476 c, t dbSNP:575751468
3486 3486 a, g dbSNP:78810983
3492 3492 c, g dbSNP:773672506
3511 3511 c, g dbSNP:768221658
3523 3523 c, t dbSNP:140302812
3532 3532 a, t dbSNP:184823952
3554 3554 a, c dbSNP:1256065
3559 3559 a, c dbSNP:192959676
3595 3595 a, g dbSNP:1256066
3599 3599 c, t dbSNP:761226052
3620 3620 a, g dbSNP:778302795
3631 3631 a, g dbSNP:542550388
3635 3635 a, g dbSNP:758933946
3664 3664 a, g dbSNP:528930460
3676 3676 c, t dbSNP:7159990
3683 3683 a, c dbSNP:370625185
3687 3687 c, t dbSNP:554065843
3695 3695 g, t dbSNP:539803187
3711 3711 c, g dbSNP:753252346
3722 3722 g, t dbSNP:368094997
3750 3750 -, ttat dbSNP:537536961
3766 3766 g, t dbSNP:577336628
3820 3820 c, t dbSNP:200501869
3863 3863 a, g dbSNP:28418648
3869 3869 a, c dbSNP:755082238
3881 3881 a, g dbSNP:370180323
3887 3887 c, t dbSNP:1152602
3889 3889 c, t dbSNP:570681995
3927 3927 a, c dbSNP:187354334
3933 3933 a, c dbSNP:535768267
3964 3964 a, g dbSNP:551506896
3976 3976 a, g dbSNP:553411787
4040 4040 a, g dbSNP:557228457
4052 4052 a, t dbSNP:549615155
4080 4080 -, tt dbSNP:538295342
4154 4154 c, g dbSNP:569383120
4221 4221 a, g dbSNP:61144058
4224 4224 a, g dbSNP:767308396
4253 4253 c, t dbSNP:761593081
4258 4258 a, t dbSNP:57296917
4271 4271 a, g dbSNP:373310647
4273 4273 a, g dbSNP:568413175
4275 4275 a, t dbSNP:774327775
4292 4292 c, t dbSNP:549588489
4308 4308 a, t dbSNP:183425904
4319 4319 a, g dbSNP:149729017
4339 4339 a, c dbSNP:139566191
4340 4340 a, g dbSNP:762491307
4423 4423 c, t dbSNP:774910066
4433 4433 c, g dbSNP:549116928
4438 4438 c, t dbSNP:560743660
4513 4513 a, g, t dbSNP:190727936
4515 4515 a, c dbSNP:371511858
4530 4530 a, g dbSNP:559983902
4577 4577 a, c dbSNP:539866395

Target ORF information:

RefSeq Version XM_011536546
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011536546

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGTAAC AAGGGCATGG AACATCTGCT CAACATGAAG
TGCAAAAATG TGGTCCCAGT GTATGACCTG CTGCTGGAGA TGCTGAATGC CCACGTGCTT
CGCGGGTGCA AGTCCTCCAT CACGGGGTCC GAGTGCAGCC CGGCAGAGGA CAGTAAAAGC
AAAGAGGGCT CCCAGAACCC ACAGTCTCAG TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22338
Accession Version NM_001214902.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1446bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product estrogen receptor beta isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB006590.1, DQ838582.1, AL355094.3 and BC024181.2. Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (d) differs in the 3' UTR and 3' coding sequence, compared to variant a. The resulting isoform (3, also known as ER-beta4) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ838582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGATGG GGAGAAAAGC AATTCATTCA TTTGAAGTTA
TCTTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001201831.1
CDS91..1536
Misc Feature(1)25..27(+)
Misc Feature(2)151..462(+)
Misc Feature(3)520..765(+)
Misc Feature(4)535..702(+)
Misc Feature(5)562..705(+)
Misc Feature(6)640..690(+)
Misc Feature(7)877..1494(+)
Misc Feature(8)982..1128(+)
Misc Feature(9)1018..1086(+)
Misc Feature(10)1297..1491(+)
Exon (1)1..452
Gene:ESR2
Gene Synonym:
Exon (2)453..625
Gene:ESR2
Gene Synonym:
Exon (3)626..742
Gene:ESR2
Gene Synonym:
Exon (4)743..1042
Gene:ESR2
Gene Synonym:
Exon (5)1043..1181
Gene:ESR2
Gene Synonym:
Exon (6)1182..1315
Gene:ESR2
Gene Synonym:
Exon (7)1316..1496
Gene:ESR2
Gene Synonym:
Exon (8)1497..2393
Gene:ESR2
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:752998368
16 16 a, g dbSNP:140514427
18 18 a, g dbSNP:779390544
32 32 a, g dbSNP:186173828
39 39 c, t dbSNP:772255075
40 40 a, g dbSNP:746385847
41 41 a, g dbSNP:774892627
42 42 a, c dbSNP:374747596
43 43 c, g dbSNP:747695780
44 44 g, t dbSNP:780545357
50 50 a, c dbSNP:544267958
54 54 c, t dbSNP:746603320
61 61 a, g dbSNP:779905252
62 62 a, c, g dbSNP:750231632
77 77 c, t dbSNP:765335664
83 83 -, gaatg dbSNP:770398805
83 83 a, c, t dbSNP:754023746
88 88 g, t dbSNP:754382190
89 89 a, t dbSNP:764034141
91 91 a, g dbSNP:760953580
95 95 a, g dbSNP:752802126
97 97 a, g dbSNP:111918185
106 106 g, t dbSNP:759956733
107 107 c, t dbSNP:774665914
109 109 c, t dbSNP:578240507
116 116 g, t dbSNP:771475824
125 125 c, g dbSNP:763399801
135 135 c, t dbSNP:146774535
137 137 a, g dbSNP:767986827
140 140 a, g dbSNP:746690121
149 149 -, aatccatc dbSNP:748819718
150 150 a, g dbSNP:371185098
154 154 a, g, t dbSNP:76299711
155 155 c, t dbSNP:778833916
166 166 g, t dbSNP:757286052
170 170 -, acggc dbSNP:772916512
170 170 a, g dbSNP:753680835
171 171 c, t dbSNP:145033525
172 172 a, g dbSNP:181439439
178 178 a, g dbSNP:750603094
182 182 -, ta dbSNP:139951512
184 184 a, g dbSNP:752813103
185 185 c, t dbSNP:767669644
186 186 a, t dbSNP:759731803
187 187 c, t dbSNP:751944011
196 196 g, t dbSNP:766687268
199 199 a, g dbSNP:61760170
207 207 a, c dbSNP:773535672
208 208 a, c, t dbSNP:577163101
218 218 a, g dbSNP:775038176
230 230 c, t dbSNP:771904224
234 234 c, g dbSNP:745470989
236 236 a, g dbSNP:778885246
240 240 c, t dbSNP:557221858
241 241 c, t dbSNP:749093040
242 242 c, t dbSNP:777634220
251 251 g, t dbSNP:558493944
254 254 a, c dbSNP:752767552
270 270 c, g dbSNP:781199121
272 272 a, g dbSNP:200128566
273 273 c, t dbSNP:751713041
289 289 a, g dbSNP:376782264
290 290 a, g dbSNP:758750077
295 295 c, g dbSNP:373249723
301 301 c, t dbSNP:750795212
302 302 a, g dbSNP:765704047
319 319 a, c dbSNP:762362679
322 322 g, t dbSNP:774889601
326 326 c, t dbSNP:61760171
342 342 a, g dbSNP:762164271
360 360 g, t dbSNP:199868673
367 367 c, t dbSNP:147382781
368 368 a, g dbSNP:142737037
372 372 c, g dbSNP:770698509
380 380 a, g dbSNP:199565279
382 382 c, t dbSNP:139503857
388 388 a, g dbSNP:568366119
389 389 c, t dbSNP:769639263
390 390 a, g dbSNP:150887025
417 417 a, c dbSNP:781253938
425 425 a, c, t dbSNP:141516067
430 430 a, g dbSNP:780323597
445 445 a, g dbSNP:148388530
450 450 c, g, t dbSNP:765590594
454 454 c, g dbSNP:751133775
456 456 a, c, g dbSNP:370669059
459 459 a, c dbSNP:142771803
462 462 c, g dbSNP:775813046
465 465 a, g dbSNP:764783863
472 472 a, g dbSNP:761663618
474 474 c, t dbSNP:138182239
480 480 a, g dbSNP:768631700
482 482 a, g dbSNP:760559822
484 484 c, g dbSNP:145711407
485 485 a, g dbSNP:200062531
486 486 c, t dbSNP:746096082
489 489 c, t dbSNP:140630557
490 490 a, g dbSNP:774742997
495 495 c, t dbSNP:749716786
500 500 c, t dbSNP:778231084
505 505 a, g dbSNP:756718563
510 510 a, g dbSNP:145757800
515 515 c, t dbSNP:779443173
518 518 a, g dbSNP:757984082
522 522 a, g dbSNP:150153463
537 537 c, t dbSNP:749898001
538 538 a, g, t dbSNP:761435805
543 543 c, t dbSNP:753657562
549 549 c, t dbSNP:763840228
550 550 a, g dbSNP:760612953
551 551 a, g dbSNP:775445438
554 554 a, g dbSNP:771893373
555 555 c, t dbSNP:200625141
558 558 a, t dbSNP:1541060
561 561 a, g dbSNP:150534198
564 564 a, c dbSNP:749478587
567 567 c, t dbSNP:373386845
572 572 a, g dbSNP:770224156
576 576 a, g dbSNP:748510590
584 584 c, t dbSNP:141760704
585 585 a, g dbSNP:151012840
594 594 a, t dbSNP:745433371
600 600 a, g dbSNP:778238323
615 615 a, g dbSNP:369907593
627 627 a, g dbSNP:752555445
628 628 c, t dbSNP:770100746
631 631 -, aat dbSNP:750091675
640 640 a, c dbSNP:767173223
650 650 c, g dbSNP:754945292
659 659 a, g dbSNP:552876311
660 660 a, g dbSNP:751392863
661 661 g, t dbSNP:766405281
663 663 c, t dbSNP:763191319
665 665 c, t dbSNP:369253565
668 668 a, t dbSNP:773394073
669 669 c, t dbSNP:374870812
670 670 a, g dbSNP:145278854
672 672 c, t dbSNP:139479509
676 676 a, g dbSNP:761893224
679 679 a, c dbSNP:760053106
680 680 a, g dbSNP:539747077
682 682 c, t dbSNP:768839285
699 699 a, c dbSNP:761261331
702 702 c, t dbSNP:776039661
703 703 c, t dbSNP:772568096
704 704 a, g dbSNP:748841139
709 709 c, t dbSNP:371856990
710 710 a, g dbSNP:368924653
718 718 c, t dbSNP:747686242
719 719 a, g dbSNP:781052752
720 720 c, g, t dbSNP:2228481
721 721 a, g dbSNP:556956556
723 723 a, g dbSNP:74808355
735 735 g, t dbSNP:750554682
737 737 a, c dbSNP:765370070
739 739 c, t dbSNP:762101051
750 750 a, c, g dbSNP:774894727
751 751 a, g dbSNP:78851986
756 756 a, g dbSNP:761268108
759 759 -, ga dbSNP:764429735
759 759 a, g dbSNP:776182715
765 765 a, g dbSNP:113888207
768 768 c, g dbSNP:746620276
771 771 c, t dbSNP:775430518
772 772 c, t dbSNP:530072718
773 773 a, c, t dbSNP:561226739
774 774 c, t dbSNP:757190866
775 775 a, g dbSNP:145387917
776 776 a, c, g, t dbSNP:199669101
778 778 a, c dbSNP:200629827
779 779 a, g dbSNP:752856261
783 783 a, g dbSNP:767711085
788 788 c, g dbSNP:200990124
795 795 c, t dbSNP:368036749
796 796 c, g dbSNP:755401425
798 798 c, t dbSNP:751889019
799 799 a, g dbSNP:766843910
801 801 a, g dbSNP:763467918
813 813 c, t dbSNP:776036845
815 815 c, t dbSNP:763594392
818 818 a, g dbSNP:760419460
820 820 a, g dbSNP:576722274
826 826 a, g dbSNP:775342550
837 837 c, t dbSNP:771849161
838 838 a, c, g dbSNP:201239439
843 843 c, t dbSNP:770801445
844 844 a, g dbSNP:543025691
845 845 a, c, t dbSNP:370979619
846 846 -, g dbSNP:753146864
847 847 c, g dbSNP:748219656
848 848 c, t dbSNP:781431063
849 849 c, g dbSNP:755168876
853 853 c, g dbSNP:751892376
857 857 c, g dbSNP:202146084
862 862 c, t dbSNP:143949374
871 871 a, g dbSNP:758834110
873 873 c, t dbSNP:750886730
874 874 g, t dbSNP:765827699
882 882 a, c dbSNP:760331553
885 885 -, c dbSNP:759924525
885 885 c, t dbSNP:554390029
888 888 a, g dbSNP:767333417
891 891 g, t dbSNP:149404315
892 892 c, t dbSNP:774048787
895 895 a, g dbSNP:770714265
897 897 c, g dbSNP:762636828
898 898 c, t dbSNP:139838202
902 902 a, c, t dbSNP:748286878
911 911 a, t dbSNP:781190983
920 920 a, c dbSNP:768870975
921 921 a, g dbSNP:747213970
924 924 c, t dbSNP:780304063
930 930 a, g dbSNP:769393357
933 933 g, t dbSNP:758845568
934 934 a, g dbSNP:750720041
936 936 a, c, t dbSNP:757821946
940 940 c, t dbSNP:752264246
943 943 c, t dbSNP:767100418
956 956 a, t dbSNP:759137869
961 961 a, g dbSNP:751277839
963 963 a, g dbSNP:527718361
964 964 a, g dbSNP:765919886
970 970 a, g dbSNP:762875795
978 978 a, g dbSNP:559087939
987 987 c, t dbSNP:769738063
991 991 c, g, t dbSNP:747372616
993 993 a, g dbSNP:776723904
994 994 g, t dbSNP:768672906
997 997 g, t dbSNP:747036560
1001 1001 a, c, t dbSNP:539389612
1005 1005 a, g dbSNP:746299554
1015 1015 a, g dbSNP:779359374
1021 1021 a, g, t dbSNP:201349732
1026 1026 g, t dbSNP:550448628
1039 1039 a, c, t dbSNP:138920605
1041 1041 -, c dbSNP:774779393
1044 1044 c, t dbSNP:777043910
1049 1049 g, t dbSNP:769145181
1050 1050 a, g dbSNP:745438689
1057 1057 a, g dbSNP:778333818
1059 1059 c, t dbSNP:145690231
1061 1061 g, t dbSNP:748895913
1062 1062 g, t dbSNP:777642861
1065 1065 c, g, t dbSNP:58256696
1074 1074 a, g dbSNP:1256049
1075 1075 a, c, t dbSNP:575267235
1076 1076 a, g dbSNP:145661652
1077 1077 a, g dbSNP:766529045
1080 1080 c, g dbSNP:141414270
1082 1082 -, t dbSNP:762454979
1087 1087 a, g dbSNP:750660776
1092 1092 c, t dbSNP:56926155
1093 1093 c, t dbSNP:149090049
1101 1101 a, g dbSNP:144986202
1106 1106 g, t dbSNP:769163374
1107 1107 a, c dbSNP:573246090
1110 1110 a, g dbSNP:146977918
1115 1115 a, g dbSNP:553390407
1126 1126 c, t dbSNP:200264592
1131 1131 a, c dbSNP:770374094
1132 1132 a, g dbSNP:372274623
1133 1133 c, t dbSNP:758311034
1141 1141 c, t dbSNP:769476765
1143 1143 c, t dbSNP:747912769
1144 1144 a, g dbSNP:368060197
1146 1146 a, c dbSNP:754998201
1148 1148 a, t dbSNP:752612054
1174 1174 c, g dbSNP:550575939
1182 1182 g, t dbSNP:141474553
1191 1191 a, g dbSNP:147847668
1192 1192 a, g dbSNP:144249047
1197 1197 c, g, t dbSNP:80118085
1198 1198 a, g dbSNP:745947456
1211 1211 g, t dbSNP:778982958
1218 1218 c, t dbSNP:531227990
1224 1224 c, t dbSNP:376348920
1225 1225 a, g dbSNP:754008155
1230 1230 c, g dbSNP:374768593
1232 1232 c, t dbSNP:112017626
1238 1238 a, c dbSNP:764274252
1240 1240 a, g dbSNP:756507443
1241 1241 c, t dbSNP:753050523
1245 1245 a, g dbSNP:768030327
1248 1248 g, t dbSNP:760024678
1252 1252 c, t dbSNP:772629994
1253 1253 a, g dbSNP:764756707
1266 1266 c, g dbSNP:1256054
1270 1270 c, t dbSNP:776464052
1272 1272 c, g dbSNP:768417560
1278 1278 a, g dbSNP:45624541
1290 1290 c, g dbSNP:775365033
1296 1296 -, tc dbSNP:746812518
1296 1296 c, g dbSNP:72548752
1297 1297 a, g dbSNP:771907276
1299 1299 g, t dbSNP:79216673
1305 1305 g, t dbSNP:778878210
1306 1306 c, g, t dbSNP:373170989
1307 1307 c, g, t dbSNP:111471356
1309 1309 a, t dbSNP:778031158
1313 1313 c, t dbSNP:78255744
1314 1314 c, t dbSNP:753066940
1318 1318 a, g dbSNP:753401843
1327 1327 c, g dbSNP:2229618
1336 1336 -, g dbSNP:34624204
1346 1346 a, g, t dbSNP:752438967
1349 1349 c, t dbSNP:767044157
1353 1353 c, t dbSNP:759440360
1354 1354 a, g dbSNP:773962693
1358 1358 a, g dbSNP:770908423
1360 1360 c, t dbSNP:142544449
1361 1361 a, g dbSNP:773306825
1363 1363 a, g dbSNP:371686799
1365 1365 a, g dbSNP:369993150
1370 1370 c, t dbSNP:146717881
1379 1379 a, t dbSNP:755668062
1380 1380 c, g dbSNP:768749310
1384 1384 a, g dbSNP:377196538
1385 1385 a, c dbSNP:211694397
1386 1386 c, t dbSNP:148775627
1387 1387 a, g dbSNP:200615874
1391 1391 c, t dbSNP:565419607
1392 1392 c, t dbSNP:368248753
1396 1396 a, g dbSNP:779536246
1407 1407 g, t dbSNP:113652563
1408 1408 a, g, t dbSNP:370716868
1413 1413 c, t dbSNP:60101369
1414 1414 a, g dbSNP:754524028
1418 1418 a, g dbSNP:751404448
1421 1421 a, g dbSNP:367855747
1422 1422 c, t dbSNP:144392940
1423 1423 a, g dbSNP:773174281
1431 1431 a, c dbSNP:765157926
1440 1440 a, g dbSNP:761939611
1441 1441 a, c dbSNP:776514667
1450 1450 c, t dbSNP:768924970
1451 1451 a, g dbSNP:139785869
1454 1454 c, t dbSNP:775944471
1455 1455 a, g dbSNP:772610168
1457 1457 c, t dbSNP:746200870
1463 1463 a, t dbSNP:146380568
1470 1470 g, t dbSNP:757823564
1471 1471 a, c dbSNP:747701419
1473 1473 c, g dbSNP:780531016
1474 1474 c, t dbSNP:754686565
1475 1475 c, t dbSNP:375446581
1479 1479 c, t dbSNP:765985203
1482 1482 a, c, t dbSNP:543310306
1483 1483 a, g dbSNP:777286766
1490 1490 a, g dbSNP:765174403
1491 1491 c, g, t dbSNP:776801399
1493 1493 c, t dbSNP:764031807
1494 1494 a, g dbSNP:370033234
1498 1498 g, t dbSNP:745969976
1512 1512 a, g dbSNP:778893833
1515 1515 c, t dbSNP:377351328
1522 1522 c, t dbSNP:373108044
1527 1527 c, g dbSNP:777942903
1533 1533 g, t dbSNP:756571791
1541 1541 a, g dbSNP:748451164
1556 1556 -, a dbSNP:753020149
1557 1557 c, t dbSNP:781731091
1560 1560 c, g dbSNP:755373668
1567 1567 a, g dbSNP:531237514
1571 1571 a, g dbSNP:561041296
1572 1572 a, g dbSNP:756808216
1584 1584 c, t dbSNP:369176105
1592 1592 c, t dbSNP:777567273
1593 1593 a, g dbSNP:758114722
1623 1623 g, t dbSNP:1152581
1636 1636 a, c dbSNP:765243492
1648 1648 c, g dbSNP:184960071
1660 1660 a, g dbSNP:754987526
1665 1665 a, g dbSNP:543219116
1668 1668 c, t dbSNP:574698914
1678 1678 a, c dbSNP:368684498
1686 1686 c, t dbSNP:551923717
1714 1714 a, g dbSNP:753357033
1727 1727 -, a dbSNP:35874406
1728 1728 c, t dbSNP:534641761
1748 1748 c, t dbSNP:776827958
1761 1761 a, c dbSNP:572063610
1765 1765 c, t dbSNP:374327245
1766 1766 a, g dbSNP:775089848
1767 1767 c, t dbSNP:562231691
1768 1768 c, t dbSNP:767489596
1770 1770 a, c, g dbSNP:774433480
1771 1771 c, g dbSNP:771046203
1779 1779 a, g dbSNP:371072055
1780 1780 c, t dbSNP:773485191
1795 1795 c, g dbSNP:769854243
1796 1796 c, t dbSNP:748554379
1797 1797 a, g dbSNP:192894852
1803 1803 a, c dbSNP:755532853
1804 1804 -, tactt dbSNP:755365572
1805 1805 -, ata dbSNP:781465098
1809 1809 a, g dbSNP:747570395
1821 1821 a, g dbSNP:138379290
1830 1830 a, c dbSNP:756892111
1831 1831 a, t dbSNP:753381745
1833 1833 -, aaca dbSNP:751885388
1836 1836 a, c dbSNP:146994281
1838 1838 c, t dbSNP:755655602
1859 1859 a, g dbSNP:370642838
1863 1863 a, t dbSNP:752567696
1876 1876 a, g dbSNP:768598288
1879 1879 -, a dbSNP:766817445
1879 1879 a, c dbSNP:767166888
1880 1880 c, t dbSNP:141329819
1881 1881 a, g, t dbSNP:766292098
1885 1885 -, g dbSNP:763409571
1896 1896 c, g dbSNP:763034969
1899 1899 c, t dbSNP:773209202
1905 1905 a, c dbSNP:770090739
1908 1908 c, t dbSNP:748273156
1909 1909 a, c, g dbSNP:74604027
1910 1910 c, g dbSNP:202224619
1913 1913 a, g dbSNP:747370497
1918 1918 a, c dbSNP:780761548
1926 1926 c, t dbSNP:543820675
1927 1927 a, c dbSNP:748807273
1928 1928 c, t dbSNP:777107369
1929 1929 c, t dbSNP:201485281
1931 1931 a, g dbSNP:752340205
1936 1936 c, t dbSNP:536416058
1938 1938 c, t dbSNP:754826501
1941 1941 -, t dbSNP:768344166
1941 1941 a, t dbSNP:751298003
1949 1949 a, g dbSNP:928554
1974 1974 a, c dbSNP:142219923
1985 1985 a, t dbSNP:527720340
1986 1986 a, g dbSNP:28440970
1990 1990 g, t dbSNP:551321938
1998 1998 a, g dbSNP:114629727
2021 2021 -, gtta dbSNP:748819053
2051 2051 a, g dbSNP:562814442
2062 2062 a, g dbSNP:8018687
2082 2082 c, t dbSNP:574533143
2096 2096 c, t dbSNP:561209885
2137 2137 c, t dbSNP:577859008
2146 2146 c, t dbSNP:541332551
2164 2164 a, g dbSNP:369615513
2179 2179 a, g dbSNP:557813812
2232 2232 a, g dbSNP:58262369
2250 2250 c, g dbSNP:558593421
2273 2273 a, c, g dbSNP:1255998
2285 2285 g, t dbSNP:770930430
2293 2293 a, g dbSNP:747171118
2335 2335 c, t dbSNP:576107158
2343 2343 a, g dbSNP:139004885

Target ORF information:

RefSeq Version NM_001214902
Organism Homo sapiens (human)
Definition Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant d, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001214902

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGATGG GGAGAAAAGC AATTCATTCA TTTGAAGTTA
TCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22461
Accession Version NM_001271876.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1425bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product estrogen receptor beta isoform 5
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB006590.1, DQ777076.1 and AL355094.3. Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (f) differs in the 3' UTR and 3' coding sequence, compared to variant a. The resulting isoform (5, also known as ER-beta4) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ777076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGGTCC TGTGTATACA AGTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001258805.1
CDS91..1515
Misc Feature(1)25..27(+)
Misc Feature(2)91..534(+)
Misc Feature(3)151..462(+)
Misc Feature(4)349..351(+)
Misc Feature(5)403..405(+)
Misc Feature(6)520..765(+)
Misc Feature(7)535..702(+)
Misc Feature(8)562..705(+)
Misc Feature(9)640..690(+)
Misc Feature(10)877..1500(+)
Misc Feature(11)982..1128(+)
Misc Feature(12)1018..1086(+)
Misc Feature(13)1297..1500(+)
Exon (1)1..452
Gene:ESR2
Gene Synonym:
Exon (2)453..625
Gene:ESR2
Gene Synonym:
Exon (3)626..742
Gene:ESR2
Gene Synonym:
Exon (4)743..1042
Gene:ESR2
Gene Synonym:
Exon (5)1043..1181
Gene:ESR2
Gene Synonym:
Exon (6)1182..1315
Gene:ESR2
Gene Synonym:
Exon (7)1316..1496
Gene:ESR2
Gene Synonym:
Exon (8)1497..1724
Gene:ESR2
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:752998368
16 16 a, g dbSNP:140514427
18 18 a, g dbSNP:779390544
32 32 a, g dbSNP:186173828
39 39 c, t dbSNP:772255075
40 40 a, g dbSNP:746385847
41 41 a, g dbSNP:774892627
42 42 a, c dbSNP:374747596
43 43 c, g dbSNP:747695780
44 44 g, t dbSNP:780545357
50 50 a, c dbSNP:544267958
54 54 c, t dbSNP:746603320
61 61 a, g dbSNP:779905252
62 62 a, c, g dbSNP:750231632
77 77 c, t dbSNP:765335664
83 83 -, gaatg dbSNP:770398805
83 83 a, c, t dbSNP:754023746
88 88 g, t dbSNP:754382190
89 89 a, t dbSNP:764034141
91 91 a, g dbSNP:760953580
95 95 a, g dbSNP:752802126
97 97 a, g dbSNP:111918185
106 106 g, t dbSNP:759956733
107 107 c, t dbSNP:774665914
109 109 c, t dbSNP:578240507
116 116 g, t dbSNP:771475824
125 125 c, g dbSNP:763399801
135 135 c, t dbSNP:146774535
137 137 a, g dbSNP:767986827
140 140 a, g dbSNP:746690121
149 149 -, aatccatc dbSNP:748819718
150 150 a, g dbSNP:371185098
154 154 a, g, t dbSNP:76299711
155 155 c, t dbSNP:778833916
166 166 g, t dbSNP:757286052
170 170 -, acggc dbSNP:772916512
170 170 a, g dbSNP:753680835
171 171 c, t dbSNP:145033525
172 172 a, g dbSNP:181439439
178 178 a, g dbSNP:750603094
182 182 -, ta dbSNP:139951512
184 184 a, g dbSNP:752813103
185 185 c, t dbSNP:767669644
186 186 a, t dbSNP:759731803
187 187 c, t dbSNP:751944011
196 196 g, t dbSNP:766687268
199 199 a, g dbSNP:61760170
207 207 a, c dbSNP:773535672
208 208 a, c, t dbSNP:577163101
218 218 a, g dbSNP:775038176
230 230 c, t dbSNP:771904224
234 234 c, g dbSNP:745470989
236 236 a, g dbSNP:778885246
240 240 c, t dbSNP:557221858
241 241 c, t dbSNP:749093040
242 242 c, t dbSNP:777634220
251 251 g, t dbSNP:558493944
254 254 a, c dbSNP:752767552
270 270 c, g dbSNP:781199121
272 272 a, g dbSNP:200128566
273 273 c, t dbSNP:751713041
289 289 a, g dbSNP:376782264
290 290 a, g dbSNP:758750077
295 295 c, g dbSNP:373249723
301 301 c, t dbSNP:750795212
302 302 a, g dbSNP:765704047
319 319 a, c dbSNP:762362679
322 322 g, t dbSNP:774889601
326 326 c, t dbSNP:61760171
342 342 a, g dbSNP:762164271
360 360 g, t dbSNP:199868673
367 367 c, t dbSNP:147382781
368 368 a, g dbSNP:142737037
372 372 c, g dbSNP:770698509
380 380 a, g dbSNP:199565279
382 382 c, t dbSNP:139503857
388 388 a, g dbSNP:568366119
389 389 c, t dbSNP:769639263
390 390 a, g dbSNP:150887025
417 417 a, c dbSNP:781253938
425 425 a, c, t dbSNP:141516067
430 430 a, g dbSNP:780323597
445 445 a, g dbSNP:148388530
450 450 c, g, t dbSNP:765590594
454 454 c, g dbSNP:751133775
456 456 a, c, g dbSNP:370669059
459 459 a, c dbSNP:142771803
462 462 c, g dbSNP:775813046
465 465 a, g dbSNP:764783863
472 472 a, g dbSNP:761663618
474 474 c, t dbSNP:138182239
480 480 a, g dbSNP:768631700
482 482 a, g dbSNP:760559822
484 484 c, g dbSNP:145711407
485 485 a, g dbSNP:200062531
486 486 c, t dbSNP:746096082
489 489 c, t dbSNP:140630557
490 490 a, g dbSNP:774742997
495 495 c, t dbSNP:749716786
500 500 c, t dbSNP:778231084
505 505 a, g dbSNP:756718563
510 510 a, g dbSNP:145757800
515 515 c, t dbSNP:779443173
518 518 a, g dbSNP:757984082
522 522 a, g dbSNP:150153463
537 537 c, t dbSNP:749898001
538 538 a, g, t dbSNP:761435805
543 543 c, t dbSNP:753657562
549 549 c, t dbSNP:763840228
550 550 a, g dbSNP:760612953
551 551 a, g dbSNP:775445438
554 554 a, g dbSNP:771893373
555 555 c, t dbSNP:200625141
558 558 a, t dbSNP:1541060
561 561 a, g dbSNP:150534198
564 564 a, c dbSNP:749478587
567 567 c, t dbSNP:373386845
572 572 a, g dbSNP:770224156
576 576 a, g dbSNP:748510590
584 584 c, t dbSNP:141760704
585 585 a, g dbSNP:151012840
594 594 a, t dbSNP:745433371
600 600 a, g dbSNP:778238323
615 615 a, g dbSNP:369907593
627 627 a, g dbSNP:752555445
628 628 c, t dbSNP:770100746
631 631 -, aat dbSNP:750091675
640 640 a, c dbSNP:767173223
650 650 c, g dbSNP:754945292
659 659 a, g dbSNP:552876311
660 660 a, g dbSNP:751392863
661 661 g, t dbSNP:766405281
663 663 c, t dbSNP:763191319
665 665 c, t dbSNP:369253565
668 668 a, t dbSNP:773394073
669 669 c, t dbSNP:374870812
670 670 a, g dbSNP:145278854
672 672 c, t dbSNP:139479509
676 676 a, g dbSNP:761893224
679 679 a, c dbSNP:760053106
680 680 a, g dbSNP:539747077
682 682 c, t dbSNP:768839285
699 699 a, c dbSNP:761261331
702 702 c, t dbSNP:776039661
703 703 c, t dbSNP:772568096
704 704 a, g dbSNP:748841139
709 709 c, t dbSNP:371856990
710 710 a, g dbSNP:368924653
718 718 c, t dbSNP:747686242
719 719 a, g dbSNP:781052752
720 720 c, g, t dbSNP:2228481
721 721 a, g dbSNP:556956556
723 723 a, g dbSNP:74808355
735 735 g, t dbSNP:750554682
737 737 a, c dbSNP:765370070
739 739 c, t dbSNP:762101051
750 750 a, c, g dbSNP:774894727
751 751 a, g dbSNP:78851986
756 756 a, g dbSNP:761268108
759 759 -, ga dbSNP:764429735
759 759 a, g dbSNP:776182715
765 765 a, g dbSNP:113888207
768 768 c, g dbSNP:746620276
771 771 c, t dbSNP:775430518
772 772 c, t dbSNP:530072718
773 773 a, c, t dbSNP:561226739
774 774 c, t dbSNP:757190866
775 775 a, g dbSNP:145387917
776 776 a, c, g, t dbSNP:199669101
778 778 a, c dbSNP:200629827
779 779 a, g dbSNP:752856261
783 783 a, g dbSNP:767711085
788 788 c, g dbSNP:200990124
795 795 c, t dbSNP:368036749
796 796 c, g dbSNP:755401425
798 798 c, t dbSNP:751889019
799 799 a, g dbSNP:766843910
801 801 a, g dbSNP:763467918
813 813 c, t dbSNP:776036845
815 815 c, t dbSNP:763594392
818 818 a, g dbSNP:760419460
820 820 a, g dbSNP:576722274
826 826 a, g dbSNP:775342550
837 837 c, t dbSNP:771849161
838 838 a, c, g dbSNP:201239439
843 843 c, t dbSNP:770801445
844 844 a, g dbSNP:543025691
845 845 a, c, t dbSNP:370979619
846 846 -, g dbSNP:753146864
847 847 c, g dbSNP:748219656
848 848 c, t dbSNP:781431063
849 849 c, g dbSNP:755168876
853 853 c, g dbSNP:751892376
857 857 c, g dbSNP:202146084
862 862 c, t dbSNP:143949374
871 871 a, g dbSNP:758834110
873 873 c, t dbSNP:750886730
874 874 g, t dbSNP:765827699
882 882 a, c dbSNP:760331553
885 885 -, c dbSNP:759924525
885 885 c, t dbSNP:554390029
888 888 a, g dbSNP:767333417
891 891 g, t dbSNP:149404315
892 892 c, t dbSNP:774048787
895 895 a, g dbSNP:770714265
897 897 c, g dbSNP:762636828
898 898 c, t dbSNP:139838202
902 902 a, c, t dbSNP:748286878
911 911 a, t dbSNP:781190983
920 920 a, c dbSNP:768870975
921 921 a, g dbSNP:747213970
924 924 c, t dbSNP:780304063
930 930 a, g dbSNP:769393357
933 933 g, t dbSNP:758845568
934 934 a, g dbSNP:750720041
936 936 a, c, t dbSNP:757821946
940 940 c, t dbSNP:752264246
943 943 c, t dbSNP:767100418
956 956 a, t dbSNP:759137869
961 961 a, g dbSNP:751277839
963 963 a, g dbSNP:527718361
964 964 a, g dbSNP:765919886
970 970 a, g dbSNP:762875795
978 978 a, g dbSNP:559087939
987 987 c, t dbSNP:769738063
991 991 c, g, t dbSNP:747372616
993 993 a, g dbSNP:776723904
994 994 g, t dbSNP:768672906
997 997 g, t dbSNP:747036560
1001 1001 a, c, t dbSNP:539389612
1005 1005 a, g dbSNP:746299554
1015 1015 a, g dbSNP:779359374
1021 1021 a, g, t dbSNP:201349732
1026 1026 g, t dbSNP:550448628
1039 1039 a, c, t dbSNP:138920605
1041 1041 -, c dbSNP:774779393
1044 1044 c, t dbSNP:777043910
1049 1049 g, t dbSNP:769145181
1050 1050 a, g dbSNP:745438689
1057 1057 a, g dbSNP:778333818
1059 1059 c, t dbSNP:145690231
1061 1061 g, t dbSNP:748895913
1062 1062 g, t dbSNP:777642861
1065 1065 c, g, t dbSNP:58256696
1074 1074 a, g dbSNP:1256049
1075 1075 a, c, t dbSNP:575267235
1076 1076 a, g dbSNP:145661652
1077 1077 a, g dbSNP:766529045
1080 1080 c, g dbSNP:141414270
1082 1082 -, t dbSNP:762454979
1087 1087 a, g dbSNP:750660776
1092 1092 c, t dbSNP:56926155
1093 1093 c, t dbSNP:149090049
1101 1101 a, g dbSNP:144986202
1106 1106 g, t dbSNP:769163374
1107 1107 a, c dbSNP:573246090
1110 1110 a, g dbSNP:146977918
1115 1115 a, g dbSNP:553390407
1126 1126 c, t dbSNP:200264592
1131 1131 a, c dbSNP:770374094
1132 1132 a, g dbSNP:372274623
1133 1133 c, t dbSNP:758311034
1141 1141 c, t dbSNP:769476765
1143 1143 c, t dbSNP:747912769
1144 1144 a, g dbSNP:368060197
1146 1146 a, c dbSNP:754998201
1148 1148 a, t dbSNP:752612054
1174 1174 c, g dbSNP:550575939
1182 1182 g, t dbSNP:141474553
1191 1191 a, g dbSNP:147847668
1192 1192 a, g dbSNP:144249047
1197 1197 c, g, t dbSNP:80118085
1198 1198 a, g dbSNP:745947456
1211 1211 g, t dbSNP:778982958
1218 1218 c, t dbSNP:531227990
1224 1224 c, t dbSNP:376348920
1225 1225 a, g dbSNP:754008155
1230 1230 c, g dbSNP:374768593
1232 1232 c, t dbSNP:112017626
1238 1238 a, c dbSNP:764274252
1240 1240 a, g dbSNP:756507443
1241 1241 c, t dbSNP:753050523
1245 1245 a, g dbSNP:768030327
1248 1248 g, t dbSNP:760024678
1252 1252 c, t dbSNP:772629994
1253 1253 a, g dbSNP:764756707
1266 1266 c, g dbSNP:1256054
1270 1270 c, t dbSNP:776464052
1272 1272 c, g dbSNP:768417560
1278 1278 a, g dbSNP:45624541
1290 1290 c, g dbSNP:775365033
1296 1296 -, tc dbSNP:746812518
1296 1296 c, g dbSNP:72548752
1297 1297 a, g dbSNP:771907276
1299 1299 g, t dbSNP:79216673
1305 1305 g, t dbSNP:778878210
1306 1306 c, g, t dbSNP:373170989
1307 1307 c, g, t dbSNP:111471356
1309 1309 a, t dbSNP:778031158
1313 1313 c, t dbSNP:78255744
1314 1314 c, t dbSNP:753066940
1318 1318 a, g dbSNP:753401843
1327 1327 c, g dbSNP:2229618
1336 1336 -, g dbSNP:34624204
1346 1346 a, g, t dbSNP:752438967
1349 1349 c, t dbSNP:767044157
1353 1353 c, t dbSNP:759440360
1354 1354 a, g dbSNP:773962693
1358 1358 a, g dbSNP:770908423
1360 1360 c, t dbSNP:142544449
1361 1361 a, g dbSNP:773306825
1363 1363 a, g dbSNP:371686799
1365 1365 a, g dbSNP:369993150
1370 1370 c, t dbSNP:146717881
1379 1379 a, t dbSNP:755668062
1380 1380 c, g dbSNP:768749310
1384 1384 a, g dbSNP:377196538
1385 1385 a, c dbSNP:211694397
1386 1386 c, t dbSNP:148775627
1387 1387 a, g dbSNP:200615874
1391 1391 c, t dbSNP:565419607
1392 1392 c, t dbSNP:368248753
1396 1396 a, g dbSNP:779536246
1407 1407 g, t dbSNP:113652563
1408 1408 a, g, t dbSNP:370716868
1413 1413 c, t dbSNP:60101369
1414 1414 a, g dbSNP:754524028
1418 1418 a, g dbSNP:751404448
1421 1421 a, g dbSNP:367855747
1422 1422 c, t dbSNP:144392940
1423 1423 a, g dbSNP:773174281
1431 1431 a, c dbSNP:765157926
1440 1440 a, g dbSNP:761939611
1441 1441 a, c dbSNP:776514667
1450 1450 c, t dbSNP:768924970
1451 1451 a, g dbSNP:139785869
1454 1454 c, t dbSNP:775944471
1455 1455 a, g dbSNP:772610168
1457 1457 c, t dbSNP:746200870
1463 1463 a, t dbSNP:146380568
1470 1470 g, t dbSNP:757823564
1471 1471 a, c dbSNP:747701419
1473 1473 c, g dbSNP:780531016
1474 1474 c, t dbSNP:754686565
1475 1475 c, t dbSNP:375446581
1479 1479 c, t dbSNP:765985203
1482 1482 a, c, t dbSNP:543310306
1483 1483 a, g dbSNP:777286766
1490 1490 a, g dbSNP:765174403
1491 1491 c, g, t dbSNP:776801399
1493 1493 c, t dbSNP:764031807
1494 1494 a, g dbSNP:370033234
1509 1509 c, t dbSNP:745928753
1511 1511 a, c, g dbSNP:17225885
1521 1521 a, t dbSNP:778068290
1529 1529 a, g dbSNP:756634129
1532 1532 g, t dbSNP:547407770
1534 1534 c, t dbSNP:753289405
1536 1536 g, t dbSNP:767909240
1543 1543 -, c dbSNP:749405121
1545 1545 g, t dbSNP:762585436
1551 1551 c, t dbSNP:757462620
1552 1552 a, g dbSNP:527656483
1556 1556 -, att dbSNP:777964107
1569 1569 c, t dbSNP:764986078
1575 1575 a, c dbSNP:761517968
1582 1582 -, ct dbSNP:756234081
1589 1589 g, t dbSNP:189371099
1595 1595 a, g dbSNP:776592562
1601 1601 c, t dbSNP:768623267
1604 1604 a, c dbSNP:760354788
1608 1608 c, t dbSNP:775564007
1611 1611 a, g dbSNP:771890859
1614 1614 g, t dbSNP:745969976
1628 1628 a, g dbSNP:778893833
1631 1631 c, t dbSNP:377351328
1638 1638 c, t dbSNP:373108044
1643 1643 c, g dbSNP:777942903
1649 1649 g, t dbSNP:756571791
1657 1657 a, g dbSNP:748451164
1672 1672 -, a dbSNP:753020149
1673 1673 c, t dbSNP:781731091
1676 1676 c, g dbSNP:755373668
1683 1683 a, g dbSNP:531237514
1687 1687 a, g dbSNP:561041296
1688 1688 a, g dbSNP:756808216
1700 1700 c, t dbSNP:369176105
1708 1708 c, t dbSNP:777567273
1709 1709 a, g dbSNP:758114722

Target ORF information:

RefSeq Version NM_001271876
Organism Homo sapiens (human)
Definition Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant f, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001271876

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGCTTTGTG
GAGCTCAGCC TGTTCGACCA AGTGCGGCTC TTGGAGAGCT GTTGGATGGA GGTGTTAATG
ATGGGGCTGA TGTGGCGCTC AATTGACCAC CCCGGCAAGC TCATCTTTGC TCCAGATCTT
GTTCTGGACA GGGATGAGGG GAAATGCGTA GAAGGAATTC TGGAAATCTT TGACATGCTC
CTGGCAACTA CTTCAAGGTT TCGAGAGTTA AAACTCCAAC ACAAAGAATA TCTCTGTGTC
AAGGCCATGA TCCTGCTCAA TTCCAGTATG TACCCTCTGG TCACAGCGAC CCAGGATGCT
GACAGCAGCC GGAAGCTGGC TCACTTGCTG AACGCCGTGA CCGATGCTTT GGTTTGGGTG
ATTGCCAAGA GCGGCATCTC CTCCCAGCAG CAATCCATGC GCCTGGCTAA CCTCCTGATG
CTCCTGTCCC ACGTCAGGCA TGCGAGGTCC TGTGTATACA AGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23139
Accession Version NM_001271877.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1320bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product estrogen receptor beta isoform 6
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB006590.1, AF074599.1 and AL161756.6. Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (g) lacks two consecutive exons in the coding region compared to variant a. The resulting isoform (6, also known as 5/6) lacks an internal segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF074599.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGATATAA AAAACTCACC ATCTAGCCTT AATTCTCCTT CCTCCTACAA CTGCAGTCAA 
TCCATCTTAC CCCTGGAGCA CGGCTCCATA TACATACCTT CCTCCTATGT AGACAGCCAC
CATGAATATC CAGCCATGAC ATTCTATAGC CCTGCTGTGA TGAATTACAG CATTCCCAGC
AATGTCACTA ACTTGGAAGG TGGGCCTGGT CGGCAGACCA CAAGCCCAAA TGTGTTGTGG
CCAACACCTG GGCACCTTTC TCCTTTAGTG GTCCATCGCC AGTTATCACA TCTGTATGCG
GAACCTCAAA AGAGTCCCTG GTGTGAAGCA AGATCGCTAG AACACACCTT ACCTGTAAAC
AGAGAGACAC TGAAAAGGAA GGTTAGTGGG AACCGTTGCG CCAGCCCTGT TACTGGTCCA
GGTTCAAAGA GGGATGCTCA CTTCTGCGCT GTCTGCAGCG ATTACGCATC GGGATATCAC
TATGGAGTCT GGTCGTGTGA AGGATGTAAG GCCTTTTTTA AAAGAAGCAT TCAAGGACAT
AATGATTATA TTTGTCCAGC TACAAATCAG TGTACAATCG ATAAAAACCG GCGCAAGAGC
TGCCAGGCCT GCCGACTTCG GAAGTGTTAC GAAGTGGGAA TGGTGAAGTG TGGCTCCCGG
AGAGAGAGAT GTGGGTACCG CCTTGTGCGG AGACAGAGAA GTGCCGACGA GCAGCTGCAC
TGTGCCGGCA AGGCCAAGAG AAGTGGCGGC CACGCGCCCC GAGTGCGGGA GCTGCTGCTG
GACGCCCTGA GCCCCGAGCA GCTAGTGCTC ACCCTCCTGG AGGCTGAGCC GCCCCATGTG
CTGATCAGCC GCCCCAGTGC GCCCTTCACC GAGGCCTCCA TGATGATGTC CCTGACCAAG
TTGGCCGACA AGGAGTTGGT ACACATGATC AGCTGGGCCA AGAAGATTCC CGGTATGTAC
CCTCTGGTCA CAGCGACCCA GGATGCTGAC AGCAGCCGGA AGCTGGCTCA CTTGCTGAAC
GCCGTGACCG ATGCTTTGGT TTGGGTGATT GCCAAGAGCG GCATCTCCTC CCAGCAGCAA
TCCATGCGCC TGGCTAACCT CCTGATGCTC CTGTCCCACG TCAGGCATGC GAGTAACAAG
GGCATGGAAC ATCTGCTCAA CATGAAGTGC AAAAATGTGG TCCCAGTGTA TGACCTGCTG
CTGGAGATGC TGAATGCCCA CGTGCTTCGC GGGTGCAAGT CCTCCATCAC GGGGTCCGAG
TGCAGCCCGG CAGAGGACAG TAAAAGCAAA GAGGGCTCCC AGAACCCACA GTCTCAGTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001258806.1
CDS91..1410
Misc Feature(1)25..27(+)
Misc Feature(2)151..462(+)
Misc Feature(3)520..765(+)
Misc Feature(4)535..702(+)
Misc Feature(5)562..705(+)
Misc Feature(6)640..690(+)
Misc Feature(7)877..1311(+)
Exon (1)1..452
Gene:ESR2
Gene Synonym:
Exon (2)453..625
Gene:ESR2
Gene Synonym:
Exon (3)626..742
Gene:ESR2
Gene Synonym:
Exon (4)743..1042
Gene:ESR2
Gene Synonym:
Exon (5)1043..1223
Gene:ESR2
Gene Synonym:
Exon (6)1224..1518
Gene:ESR2
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:752998368
16 16 a, g dbSNP:140514427
18 18 a, g dbSNP:779390544
32 32 a, g dbSNP:186173828
39 39 c, t dbSNP:772255075
40 40 a, g dbSNP:746385847
41 41 a, g dbSNP:774892627
42 42 a, c dbSNP:374747596
43 43 c, g dbSNP:747695780
44 44 g, t dbSNP:780545357
50 50 a, c dbSNP:544267958
54 54 c, t dbSNP:746603320
61 61 a, g dbSNP:779905252
62 62 a, c, g dbSNP:750231632
77 77 c, t dbSNP:765335664
83 83 -, gaatg dbSNP:770398805
83 83 a, c, t dbSNP:754023746
88 88 g, t dbSNP:754382190
89 89 a, t dbSNP:764034141
91 91 a, g dbSNP:760953580
95 95 a, g dbSNP:752802126
97 97 a, g dbSNP:111918185
106 106 g, t dbSNP:759956733
107 107 c, t dbSNP:774665914
109 109 c, t dbSNP:578240507
116 116 g, t dbSNP:771475824
125 125 c, g dbSNP:763399801
135 135 c, t dbSNP:146774535
137 137 a, g dbSNP:767986827
140 140 a, g dbSNP:746690121
149 149 -, aatccatc dbSNP:748819718
150 150 a, g dbSNP:371185098
154 154 a, g, t dbSNP:76299711
155 155 c, t dbSNP:778833916
166 166 g, t dbSNP:757286052
170 170 -, acggc dbSNP:772916512
170 170 a, g dbSNP:753680835
171 171 c, t dbSNP:145033525
172 172 a, g dbSNP:181439439
178 178 a, g dbSNP:750603094
182 182 -, ta dbSNP:139951512
184 184 a, g dbSNP:752813103
185 185 c, t dbSNP:767669644
186 186 a, t dbSNP:759731803
187 187 c, t dbSNP:751944011
196 196 g, t dbSNP:766687268
199 199 a, g dbSNP:61760170
207 207 a, c dbSNP:773535672
208 208 a, c, t dbSNP:577163101
218 218 a, g dbSNP:775038176
230 230 c, t dbSNP:771904224
234 234 c, g dbSNP:745470989
236 236 a, g dbSNP:778885246
240 240 c, t dbSNP:557221858
241 241 c, t dbSNP:749093040
242 242 c, t dbSNP:777634220
251 251 g, t dbSNP:558493944
254 254 a, c dbSNP:752767552
270 270 c, g dbSNP:781199121
272 272 a, g dbSNP:200128566
273 273 c, t dbSNP:751713041
289 289 a, g dbSNP:376782264
290 290 a, g dbSNP:758750077
295 295 c, g dbSNP:373249723
301 301 c, t dbSNP:750795212
302 302 a, g dbSNP:765704047
319 319 a, c dbSNP:762362679
322 322 g, t dbSNP:774889601
326 326 c, t dbSNP:61760171
342 342 a, g dbSNP:762164271
360 360 g, t dbSNP:199868673
367 367 c, t dbSNP:147382781
368 368 a, g dbSNP:142737037
372 372 c, g dbSNP:770698509
380 380 a, g dbSNP:199565279
382 382 c, t dbSNP:139503857
388 388 a, g dbSNP:568366119
389 389 c, t dbSNP:769639263
390 390 a, g dbSNP:150887025
417