The following F5 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F5 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 6675bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||coagulation factor V precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU279657.1, AK226079.1,
M16967.1 and Z99572.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 14, 2006 this sequence version replaced gi:105990534.
Summary: This gene encodes an essential cofactor of the blood
coagulation cascade. This factor circulates in plasma, and is
converted to the active form by the release of the activation
peptide by thrombin during coagulation. This generates a heavy
chain and a light chain which are held together by calcium ions.
The activated protein is a cofactor that participates with
activated coagulation factor X to activate prothrombin to thrombin.
Defects in this gene result in either an autosomal recessive
hemorrhagic diathesis or an autosomal dominant form of
thrombophilia, which is known as activated protein C resistance.
[provided by RefSeq, Oct 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: M16967.1, AK226079.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: full length.