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ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) [Homo sapiens (human)]

Gene Symbol ALDH2
Entrez Gene ID 217
Full Name aldehyde dehydrogenase 2 family (mitochondrial)
Synonyms ALDH-E2, ALDHI, ALDM
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.2

Summary This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]. lac of sum
Disorder MIM:

100650

Disorder Html: Alcohol sensitivity, acute, 610251 (3); {Hangover, susceptibility





The following ALDH2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALDH2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23457 NM_000690 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99
OHu23602 NM_001204889 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu23457
Accession Version NM_000690.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1554bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product aldehyde dehydrogenase, mitochondrial isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC353712.1, BC002967.1 and CB851683.1. This sequence is a reference standard in the RefSeqGene project. On Mar 11, 2011 this sequence version replaced gi:25777731. Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC002967.1, AY621070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG AAGATGTGGA CAAGGCAGTG
AAGGCCGCCC GGGCCGCCTT CCAGCTGGGC TCACCTTGGC GCCGCATGGA CGCATCACAC
AGGGGCCGGC TGCTGAACCG CCTGGCCGAT CTGATCGAGC GGGACCGGAC CTACCTGGCG
GCCTTGGAGA CCCTGGACAA TGGCAAGCCC TATGTCATCT CCTACCTGGT GGATTTGGAC
ATGGTCCTCA AATGTCTCCG GTATTATGCC GGCTGGGCTG ATAAGTACCA CGGGAAAACC
ATCCCCATTG ACGGAGACTT CTTCAGCTAC ACACGCCATG AACCTGTGGG GGTGTGCGGG
CAGATCATTC CGTGGAATTT CCCGCTCCTG ATGCAAGCAT GGAAGCTGGG CCCAGCCTTG
GCAACTGGAA ACGTGGTTGT GATGAAGGTA GCTGAGCAGA CACCCCTCAC CGCCCTCTAT
GTGGCCAACC TGATCAAGGA GGCTGGCTTT CCCCCTGGTG TGGTCAACAT TGTGCCTGGA
TTTGGCCCCA CGGCTGGGGC CGCCATTGCC TCCCATGAGG ATGTGGACAA AGTGGCATTC
ACAGGCTCCA CTGAGATTGG CCGCGTAATC CAGGTTGCTG CTGGGAGCAG CAACCTCAAG
AGAGTGACCT TGGAGCTGGG GGGGAAGAGC CCCAACATCA TCATGTCAGA TGCCGATATG
GATTGGGCCG TGGAACAGGC CCACTTCGCC CTGTTCTTCA ACCAGGGCCA GTGCTGCTGT
GCCGGCTCCC GGACCTTCGT GCAGGAGGAC ATCTATGATG AGTTTGTGGA GCGGAGCGTT
GCCCGGGCCA AGTCTCGGGT GGTCGGGAAC CCCTTTGATA GCAAGACCGA GCAGGGGCCG
CAGGTGGATG AAACTCAGTT TAAGAAGATC CTCGGCTACA TCAACACGGG GAAGCAAGAG
GGGGCGAAGC TGCTGTGTGG TGGGGGCATT GCTGCTGACC GTGGTTACTT CATCCAGCCC
ACTGTGTTTG GAGATGTGCA GGATGGCATG ACCATCGCCA AGGAGGAGAT CTTCGGGCCA
GTGATGCAGA TCCTGAAGTT CAAGACCATA GAGGAGGTTG TTGGGAGAGC CAACAATTCC
ACGTACGGGC TGGCCGCAGC TGTCTTCACA AAGGATTTGG ACAAGGCCAA TTACCTGTCC
CAGGCCCTCC AGGCGGGCAC TGTGTGGGTC AACTGCTATG ATGTGTTTGG AGCCCAGTCA
CCCTTTGGTG GCTACAAGAT GTCGGGGAGT GGCCGGGAGT TGGGCGAGTA CGGGCTGCAG
GCATACACTG AAGTGAAAAC TGTCACAGTC AAAGTGCCTC AGAAGAACTC ATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000681.2
CDS97..1650
Misc Feature(1)85..87(+)
Misc Feature(2)103..1644(+)
Misc Feature(3)187..1629(+)
Misc Feature(4)361..1629(+)
Misc Feature(5)640..1344(+)
Misc Feature(6)652..1053(+)
Misc Feature(7)652..654(+)
Exon (1)1..210
Gene:ALDH2
Gene Synonym:
Exon (2)211..315
Gene:ALDH2
Gene Synonym:
Exon (3)316..456
Gene:ALDH2
Gene Synonym:
Exon (4)457..536
Gene:ALDH2
Gene Synonym:
Exon (5)537..648
Gene:ALDH2
Gene Synonym:
Exon (6)649..777
Gene:ALDH2
Gene Synonym:
Exon (7)778..891
Gene:ALDH2
Gene Synonym:
Exon (8)892..994
Gene:ALDH2
Gene Synonym:
Exon (9)995..1179
Gene:ALDH2
Gene Synonym:
Exon (10)1180..1344
Gene:ALDH2
Gene Synonym:
Exon (11)1345..1502
Gene:ALDH2
Gene Synonym:
Exon (12)1503..1617
Gene:ALDH2
Gene Synonym:
Exon (13)1618..2060
Gene:ALDH2
Gene Synonym:
Translation
Position Chain Variation Link
2 2 c, t dbSNP:569534440
24 24 a, g dbSNP:186586514
47 47 a, g dbSNP:368926957
61 61 a, g dbSNP:764415326
66 66 a, c dbSNP:533001896
71 71 a, c dbSNP:762299805
78 78 c, t dbSNP:765749495
90 90 c, g dbSNP:750453063
94 94 a, g dbSNP:758442315
100 100 c, t dbSNP:777511085
105 105 c, t dbSNP:6490301
109 109 a, g dbSNP:551088152
115 115 c, g dbSNP:766577822
116 116 a, g dbSNP:566590864
134 134 -, gcc dbSNP:764941692
135 135 c, g dbSNP:1064903
142 142 c, t dbSNP:755268259
146 146 g, t dbSNP:372948453
162 162 a, c dbSNP:781131621
168 168 a, c, t dbSNP:200369180
177 177 c, t dbSNP:779416753
182 182 a, g dbSNP:756057023
213 213 g, t dbSNP:200757003
217 217 a, c, g dbSNP:141574314
228 228 a, g dbSNP:376595585
239 239 c, t dbSNP:757254188
240 240 c, t dbSNP:769828747
241 241 a, g, t dbSNP:778279256
253 253 a, g dbSNP:771649244
265 265 a, g dbSNP:775156542
269 269 a, g dbSNP:748467000
270 270 c, t dbSNP:770124797
272 272 c, t dbSNP:773666853
279 279 c, t dbSNP:146739827
298 298 a, g dbSNP:763365886
304 304 a, g dbSNP:771527950
307 307 a, g dbSNP:774238705
310 310 a, g dbSNP:369662183
320 320 a, g dbSNP:777988122
326 326 a, t dbSNP:749678731
330 330 a, g dbSNP:771277872
335 335 c, t dbSNP:140347209
336 336 a, g dbSNP:142646023
342 342 c, t dbSNP:574259526
343 343 a, g dbSNP:375845001
346 346 c, g, t dbSNP:760971491
347 347 a, g dbSNP:199624420
351 351 c, t dbSNP:151016544
355 355 c, t dbSNP:765039944
357 357 c, g dbSNP:750341773
365 365 g, t dbSNP:758376495
366 366 a, c dbSNP:779535686
367 367 a, t dbSNP:751128369
368 368 c, g dbSNP:754530560
370 370 a, c dbSNP:201582342
375 375 a, g dbSNP:749574153
377 377 a, g dbSNP:201745983
379 379 c, t dbSNP:140919090
387 387 c, t dbSNP:746346111
392 392 a, c dbSNP:772769308
394 394 a, c dbSNP:775694148
397 397 -, ag dbSNP:758654733
397 397 a, g dbSNP:747096195
399 399 a, g dbSNP:768692057
403 403 c, t dbSNP:150202179
404 404 a, g dbSNP:761993467
409 409 c, t dbSNP:13306164
415 415 c, t dbSNP:773061919
416 416 a, g, t dbSNP:141696414
421 421 g, t dbSNP:766318505
423 423 a, c, t dbSNP:751006312
424 424 c, g, t dbSNP:147086207
432 432 c, t dbSNP:199967065
433 433 a, g, t dbSNP:755761896
436 436 c, t dbSNP:190764869
437 437 a, g dbSNP:758915089
439 439 a, g dbSNP:376099569
443 443 a, g dbSNP:747014064
448 448 c, t dbSNP:768761406
456 456 a, g dbSNP:540044752
475 475 a, g dbSNP:367911769
486 486 a, c dbSNP:138443541
488 488 a, g dbSNP:774052763
491 491 c, t dbSNP:759512257
502 502 -, acatctccta dbSNP:751690737
502 502 c, g, t dbSNP:771960765
504 504 -, g dbSNP:755001438
505 505 c, g dbSNP:760105168
516 516 c, g dbSNP:141373324
527 527 a, c, g dbSNP:753520756
528 528 a, t dbSNP:766849182
535 535 c, t dbSNP:751931265
536 536 a, g dbSNP:371993659
543 543 g, t dbSNP:753125040
544 544 a, g dbSNP:141629803
545 545 c, g dbSNP:756650696
546 546 a, c dbSNP:372921830
561 561 a, g dbSNP:753972907
567 567 c, t dbSNP:575953094
568 568 a, c, g dbSNP:779006912
580 580 c, t dbSNP:758149074
581 581 c, g dbSNP:779941847
584 584 c, t dbSNP:746940858
588 588 c, t dbSNP:533704716
589 589 a, g dbSNP:144375294
599 599 c, t dbSNP:776223807
603 603 c, t dbSNP:747670612
607 607 a, t dbSNP:375708006
610 610 c, t dbSNP:368356402
611 611 a, g dbSNP:762718195
619 619 a, c dbSNP:767739457
627 627 c, g dbSNP:775896862
633 633 c, t dbSNP:201725825
634 634 a, g dbSNP:764594848
636 636 c, g dbSNP:753847903
647 647 c, t dbSNP:191240032
648 648 a, g dbSNP:765448984
660 660 a, g dbSNP:58280059
675 675 a, g dbSNP:758493011
692 692 c, t dbSNP:766713154
706 706 a, g dbSNP:780065997
708 708 c, t dbSNP:751364520
709 709 a, g dbSNP:754845817
722 722 a, t dbSNP:781185157
723 723 a, g dbSNP:752652573
724 724 a, g dbSNP:756140607
741 741 c, t dbSNP:777131735
744 744 c, g dbSNP:144641798
747 747 c, t dbSNP:138201631
748 748 a, g dbSNP:377123780
754 754 c, t dbSNP:747323948
761 761 a, c dbSNP:540073928
771 771 a, c, g dbSNP:777018900
777 777 g, t dbSNP:770348553
789 789 c, t dbSNP:771771961
795 795 c, t dbSNP:781479853
799 799 a, g dbSNP:748550381
805 805 a, g, t dbSNP:529768244
808 808 g, t dbSNP:749694206
810 810 a, g dbSNP:763423158
815 815 a, g dbSNP:771107075
822 822 c, t dbSNP:774642632
825 825 c, t dbSNP:759815398
827 827 c, t dbSNP:543030829
828 828 a, g dbSNP:139862632
837 837 c, t dbSNP:111277749
838 838 a, g dbSNP:760546011
845 845 c, t dbSNP:111540940
851 851 a, g dbSNP:753791195
859 859 a, c, g dbSNP:544714733
863 863 a, g dbSNP:749950720
898 898 c, t dbSNP:201835306
899 899 a, g dbSNP:765859442
900 900 c, t dbSNP:538246934
901 901 a, g dbSNP:754656921
906 906 a, c dbSNP:778189721
916 916 g, t dbSNP:749680221
918 918 c, t dbSNP:757770420
925 925 a, g, t dbSNP:139133423
935 935 -, a dbSNP:71445558
937 937 -, a dbSNP:749630753
946 946 c, t dbSNP:150631941
953 953 -, g dbSNP:771889973
954 954 a, g, t dbSNP:554937672
954 954 -, g dbSNP:775259976
955 955 a, c, g, t dbSNP:145077856
956 956 a, c, g, t dbSNP:776421832
959 959 a, g dbSNP:773112716
962 962 a, g dbSNP:762922297
965 965 a, g dbSNP:372262254
970 970 -, a dbSNP:768044419
980 980 -, t dbSNP:776136452
981 981 a, g dbSNP:765912648
989 989 a, c dbSNP:148698157
990 990 c, t dbSNP:759174174
991 991 a, g dbSNP:142271678
997 997 a, c, g, t dbSNP:571588910
999 999 c, t dbSNP:558605071
1005 1005 c, g, t dbSNP:147887880
1006 1006 a, g dbSNP:201108880
1011 1011 a, g dbSNP:141555810
1017 1017 a, c dbSNP:749044025
1023 1023 c, t dbSNP:565642382
1024 1024 g, t dbSNP:534531260
1029 1029 g, t dbSNP:759563266
1032 1032 a, c, t dbSNP:771673604
1059 1059 c, t dbSNP:760390936
1066 1066 c, t dbSNP:763851306
1067 1067 a, g dbSNP:372053825
1070 1070 a, c dbSNP:763250692
1074 1074 c, t dbSNP:766818746
1075 1075 a, g dbSNP:751980357
1078 1078 c, t dbSNP:755579750
1082 1082 a, t dbSNP:376029750
1091 1091 a, g dbSNP:752792758
1094 1094 a, g dbSNP:756266195
1106 1106 a, t dbSNP:1062136
1108 1108 c, t dbSNP:202226446
1109 1109 a, g dbSNP:749059028
1113 1113 c, t dbSNP:147049749
1114 1114 a, g dbSNP:756978401
1117 1117 g, t dbSNP:778805131
1119 1119 c, t dbSNP:370850207
1120 1120 c, t dbSNP:767381323
1121 1121 a, g dbSNP:775082307
1123 1123 g, t dbSNP:746521872
1130 1130 c, t dbSNP:768374581
1132 1132 a, c, t dbSNP:776126532
1133 1133 a, g dbSNP:766650595
1136 1136 c, t dbSNP:774840012
1140 1140 c, t dbSNP:759981145
1146 1146 c, t dbSNP:112460655
1158 1158 c, g dbSNP:768020372
1167 1167 a, g dbSNP:141025702
1176 1176 a, g dbSNP:752737734
1184 1184 a, c dbSNP:769503071
1186 1186 a, g, t dbSNP:546693939
1195 1195 c, t dbSNP:772515139
1198 1198 a, g dbSNP:775949935
1203 1203 a, g dbSNP:201721832
1209 1209 c, t dbSNP:568437854
1210 1210 a, g dbSNP:764073001
1222 1222 a, g dbSNP:201023185
1223 1223 c, t dbSNP:551054294
1224 1224 a, c, g dbSNP:182362882
1226 1226 c, g dbSNP:758039402
1227 1227 g, t dbSNP:780035440
1229 1229 a, g dbSNP:751540537
1236 1236 a, c, g dbSNP:150253385
1239 1239 -, gc dbSNP:773035280
1241 1241 a, c, t dbSNP:372769067
1242 1242 a, g dbSNP:769295295
1248 1248 a, g dbSNP:777507942
1249 1249 c, g dbSNP:748985887
1252 1252 c, t dbSNP:772390903
1264 1264 a, g dbSNP:775896971
1271 1271 c, t dbSNP:200738174
1276 1276 a, c, t dbSNP:761154464
1287 1287 c, t dbSNP:138931620
1294 1294 c, t dbSNP:149442966
1299 1299 c, t dbSNP:765328106
1303 1303 c, t dbSNP:201705553
1305 1305 c, t dbSNP:750644484
1314 1314 g, t dbSNP:763334012
1323 1323 c, t dbSNP:766266356
1333 1333 a, g dbSNP:751415641
1338 1338 a, g dbSNP:754808238
1349 1349 c, t dbSNP:550022818
1350 1350 c, g, t dbSNP:199811756
1351 1351 a, g dbSNP:777079274
1353 1353 a, g dbSNP:764022056
1362 1362 a, g dbSNP:753304028
1365 1365 a, g dbSNP:756781003
1383 1383 c, t dbSNP:764776351
1384 1384 a, g dbSNP:750085443
1385 1385 c, t dbSNP:374377652
1387 1387 a, g dbSNP:144598865
1398 1398 c, t dbSNP:138505396
1402 1402 a, c dbSNP:368435076
1404 1404 a, g dbSNP:778449798
1406 1406 c, g dbSNP:749863724
1418 1418 c, t dbSNP:771107373
1419 1419 a, g dbSNP:141556759
1422 1422 c, t dbSNP:746086528
1431 1431 c, t dbSNP:772193708
1449 1449 a, g dbSNP:775286182
1453 1453 c, t dbSNP:760416164
1458 1458 a, c dbSNP:547207199
1459 1459 a, g dbSNP:776526118
1461 1461 a, g dbSNP:761778133
1466 1466 a, g dbSNP:764713289
1470 1470 c, t dbSNP:371851241
1477 1477 c, g dbSNP:201405479
1480 1480 a, g dbSNP:765981127
1482 1482 a, c, t dbSNP:753058436
1485 1485 c, t dbSNP:536321330
1489 1489 c, g dbSNP:754387972
1490 1490 c, t dbSNP:757893333
1491 1491 a, g dbSNP:778990792
1503 1503 c, g dbSNP:759333754
1521 1521 a, g dbSNP:764536284
1542 1542 -, tgg dbSNP:751776846
1546 1546 a, g dbSNP:754265114
1559 1559 c, t dbSNP:371493214
1560 1560 a, g dbSNP:190914158
1563 1563 a, g dbSNP:1064933
1566 1566 c, t dbSNP:750466695
1569 1569 a, c dbSNP:758384827
1570 1570 c, t dbSNP:199724286
1571 1571 a, g dbSNP:747227657
1575 1575 a, g dbSNP:755207315
1576 1576 c, t dbSNP:780899853
1581 1581 c, t dbSNP:747970101
1582 1582 a, g dbSNP:769724893
1587 1587 c, g, t dbSNP:201939387
1593 1593 a, g dbSNP:770346038
1606 1606 a, g dbSNP:671
1611 1611 a, g dbSNP:569388000
1612 1612 a, c dbSNP:767280255
1644 1644 c, t dbSNP:775259939
1647 1647 a, g dbSNP:760414925
1651 1651 a, g dbSNP:765515172
1658 1658 a, g dbSNP:199997803
1662 1662 a, g dbSNP:187335908
1663 1663 c, t dbSNP:763302651
1677 1677 c, t dbSNP:540182020
1679 1679 c, t dbSNP:751588480
1686 1686 a, g dbSNP:759588558
1688 1688 a, g dbSNP:375668624
1693 1693 a, g dbSNP:369765587
1729 1729 c, t dbSNP:370433121
1731 1731 c, g dbSNP:755554206
1765 1765 -, a dbSNP:574551187
1777 1777 a, g dbSNP:113787291
1803 1803 c, t dbSNP:58352818
1864 1864 a, g dbSNP:548292659
1878 1878 c, t dbSNP:561559310
1927 1927 -, cgctt dbSNP:572001362
1928 1928 c, t dbSNP:192282635
1942 1942 c, t dbSNP:77603030
1943 1943 a, g dbSNP:552684652
1949 1949 a, g dbSNP:553112128
1968 1968 c, t dbSNP:572829790
1997 1997 a, t dbSNP:571106658
2008 2008 c, t dbSNP:185494407
2013 2013 g, t dbSNP:770699571
2048 2048 g, t dbSNP:778739435

Target ORF information:

RefSeq Version NM_000690
Organism Homo sapiens (human)
Definition Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000690

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG AAGATGTGGA CAAGGCAGTG
AAGGCCGCCC GGGCCGCCTT CCAGCTGGGC TCACCTTGGC GCCGCATGGA CGCATCACAC
AGGGGCCGGC TGCTGAACCG CCTGGCCGAT CTGATCGAGC GGGACCGGAC CTACCTGGCG
GCCTTGGAGA CCCTGGACAA TGGCAAGCCC TATGTCATCT CCTACCTGGT GGATTTGGAC
ATGGTCCTCA AATGTCTCCG GTATTATGCC GGCTGGGCTG ATAAGTACCA CGGGAAAACC
ATCCCCATTG ACGGAGACTT CTTCAGCTAC ACACGCCATG AACCTGTGGG GGTGTGCGGG
CAGATCATTC CGTGGAATTT CCCGCTCCTG ATGCAAGCAT GGAAGCTGGG CCCAGCCTTG
GCAACTGGAA ACGTGGTTGT GATGAAGGTA GCTGAGCAGA CACCCCTCAC CGCCCTCTAT
GTGGCCAACC TGATCAAGGA GGCTGGCTTT CCCCCTGGTG TGGTCAACAT TGTGCCTGGA
TTTGGCCCCA CGGCTGGGGC CGCCATTGCC TCCCATGAGG ATGTGGACAA AGTGGCATTC
ACAGGCTCCA CTGAGATTGG CCGCGTAATC CAGGTTGCTG CTGGGAGCAG CAACCTCAAG
AGAGTGACCT TGGAGCTGGG GGGGAAGAGC CCCAACATCA TCATGTCAGA TGCCGATATG
GATTGGGCCG TGGAACAGGC CCACTTCGCC CTGTTCTTCA ACCAGGGCCA GTGCTGCTGT
GCCGGCTCCC GGACCTTCGT GCAGGAGGAC ATCTATGATG AGTTTGTGGA GCGGAGCGTT
GCCCGGGCCA AGTCTCGGGT GGTCGGGAAC CCCTTTGATA GCAAGACCGA GCAGGGGCCG
CAGGTGGATG AAACTCAGTT TAAGAAGATC CTCGGCTACA TCAACACGGG GAAGCAAGAG
GGGGCGAAGC TGCTGTGTGG TGGGGGCATT GCTGCTGACC GTGGTTACTT CATCCAGCCC
ACTGTGTTTG GAGATGTGCA GGATGGCATG ACCATCGCCA AGGAGGAGAT CTTCGGGCCA
GTGATGCAGA TCCTGAAGTT CAAGACCATA GAGGAGGTTG TTGGGAGAGC CAACAATTCC
ACGTACGGGC TGGCCGCAGC TGTCTTCACA AAGGATTTGG ACAAGGCCAA TTACCTGTCC
CAGGCCCTCC AGGCGGGCAC TGTGTGGGTC AACTGCTATG ATGTGTTTGG AGCCCAGTCA
CCCTTTGGTG GCTACAAGAT GTCGGGGAGT GGCCGGGAGT TGGGCGAGTA CGGGCTGCAG
GCATACACTG AAGTGAAAAC TGTCACAGTC AAAGTGCCTC AGAAGAACTC ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23602
Accession Version NM_001204889.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1413bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product aldehyde dehydrogenase, mitochondrial isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC353712.1, AK301375.1, BC002967.1 and CB851683.1. Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK301375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG CCTTGGAGAC CCTGGACAAT
GGCAAGCCCT ATGTCATCTC CTACCTGGTG GATTTGGACA TGGTCCTCAA ATGTCTCCGG
TATTATGCCG GCTGGGCTGA TAAGTACCAC GGGAAAACCA TCCCCATTGA CGGAGACTTC
TTCAGCTACA CACGCCATGA ACCTGTGGGG GTGTGCGGGC AGATCATTCC GTGGAATTTC
CCGCTCCTGA TGCAAGCATG GAAGCTGGGC CCAGCCTTGG CAACTGGAAA CGTGGTTGTG
ATGAAGGTAG CTGAGCAGAC ACCCCTCACC GCCCTCTATG TGGCCAACCT GATCAAGGAG
GCTGGCTTTC CCCCTGGTGT GGTCAACATT GTGCCTGGAT TTGGCCCCAC GGCTGGGGCC
GCCATTGCCT CCCATGAGGA TGTGGACAAA GTGGCATTCA CAGGCTCCAC TGAGATTGGC
CGCGTAATCC AGGTTGCTGC TGGGAGCAGC AACCTCAAGA GAGTGACCTT GGAGCTGGGG
GGGAAGAGCC CCAACATCAT CATGTCAGAT GCCGATATGG ATTGGGCCGT GGAACAGGCC
CACTTCGCCC TGTTCTTCAA CCAGGGCCAG TGCTGCTGTG CCGGCTCCCG GACCTTCGTG
CAGGAGGACA TCTATGATGA GTTTGTGGAG CGGAGCGTTG CCCGGGCCAA GTCTCGGGTG
GTCGGGAACC CCTTTGATAG CAAGACCGAG CAGGGGCCGC AGGTGGATGA AACTCAGTTT
AAGAAGATCC TCGGCTACAT CAACACGGGG AAGCAAGAGG GGGCGAAGCT GCTGTGTGGT
GGGGGCATTG CTGCTGACCG TGGTTACTTC ATCCAGCCCA CTGTGTTTGG AGATGTGCAG
GATGGCATGA CCATCGCCAA GGAGGAGATC TTCGGGCCAG TGATGCAGAT CCTGAAGTTC
AAGACCATAG AGGAGGTTGT TGGGAGAGCC AACAATTCCA CGTACGGGCT GGCCGCAGCT
GTCTTCACAA AGGATTTGGA CAAGGCCAAT TACCTGTCCC AGGCCCTCCA GGCGGGCACT
GTGTGGGTCA ACTGCTATGA TGTGTTTGGA GCCCAGTCAC CCTTTGGTGG CTACAAGATG
TCGGGGAGTG GCCGGGAGTT GGGCGAGTAC GGGCTGCAGG CATACACTGA AGTGAAAACT
GTCACAGTCA AAGTGCCTCA GAAGAACTCA TAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001191818.1
CDS97..1509
Misc Feature(1)85..87(+)
Misc Feature(2)103..1503(+)
Misc Feature(3)187..1488(+)
Misc Feature(4)385..1488(+)
Misc Feature(5)499..1203(+)
Misc Feature(6)511..912(+)
Exon (1)1..210
Gene:ALDH2
Gene Synonym:
Exon (2)211..315
Gene:ALDH2
Gene Synonym:
Exon (3)316..395
Gene:ALDH2
Gene Synonym:
Exon (4)396..507
Gene:ALDH2
Gene Synonym:
Exon (5)508..636
Gene:ALDH2
Gene Synonym:
Exon (6)637..750
Gene:ALDH2
Gene Synonym:
Exon (7)751..853
Gene:ALDH2
Gene Synonym:
Exon (8)854..1038
Gene:ALDH2
Gene Synonym:
Exon (9)1039..1203
Gene:ALDH2
Gene Synonym:
Exon (10)1204..1361
Gene:ALDH2
Gene Synonym:
Exon (11)1362..1476
Gene:ALDH2
Gene Synonym:
Exon (12)1477..1919
Gene:ALDH2
Gene Synonym:
Translation
Position Chain Variation Link
2 2 c, t dbSNP:569534440
24 24 a, g dbSNP:186586514
47 47 a, g dbSNP:368926957
61 61 a, g dbSNP:764415326
66 66 a, c dbSNP:533001896
71 71 a, c dbSNP:762299805
78 78 c, t dbSNP:765749495
90 90 c, g dbSNP:750453063
94 94 a, g dbSNP:758442315
100 100 c, t dbSNP:777511085
105 105 c, t dbSNP:6490301
109 109 a, g dbSNP:551088152
115 115 c, g dbSNP:766577822
116 116 a, g dbSNP:566590864
134 134 -, gcc dbSNP:764941692
135 135 c, g dbSNP:1064903
142 142 c, t dbSNP:755268259
146 146 g, t dbSNP:372948453
162 162 a, c dbSNP:781131621
168 168 a, c, t dbSNP:200369180
177 177 c, t dbSNP:779416753
182 182 a, g dbSNP:756057023
213 213 g, t dbSNP:200757003
217 217 a, c, g dbSNP:141574314
228 228 a, g dbSNP:376595585
239 239 c, t dbSNP:757254188
240 240 c, t dbSNP:769828747
241 241 a, g, t dbSNP:778279256
253 253 a, g dbSNP:771649244
265 265 a, g dbSNP:775156542
269 269 a, g dbSNP:748467000
270 270 c, t dbSNP:770124797
272 272 c, t dbSNP:773666853
279 279 c, t dbSNP:146739827
298 298 a, g dbSNP:763365886
304 304 a, g dbSNP:771527950
307 307 a, g dbSNP:774238705
310 310 a, g dbSNP:369662183
334 334 a, g dbSNP:367911769
345 345 a, c dbSNP:138443541
347 347 a, g dbSNP:774052763
350 350 c, t dbSNP:759512257
361 361 -, acatctccta dbSNP:751690737
361 361 c, g, t dbSNP:771960765
363 363 -, g dbSNP:755001438
364 364 c, g dbSNP:760105168
375 375 c, g dbSNP:141373324
386 386 a, c, g dbSNP:753520756
387 387 a, t dbSNP:766849182
394 394 c, t dbSNP:751931265
395 395 a, g dbSNP:371993659
402 402 g, t dbSNP:753125040
403 403 a, g dbSNP:141629803
404 404 c, g dbSNP:756650696
405 405 a, c dbSNP:372921830
420 420 a, g dbSNP:753972907
426 426 c, t dbSNP:575953094
427 427 a, c, g dbSNP:779006912
439 439 c, t dbSNP:758149074
440 440 c, g dbSNP:779941847
443 443 c, t dbSNP:746940858
447 447 c, t dbSNP:533704716
448 448 a, g dbSNP:144375294
458 458 c, t dbSNP:776223807
462 462 c, t dbSNP:747670612
466 466 a, t dbSNP:375708006
469 469 c, t dbSNP:368356402
470 470 a, g dbSNP:762718195
478 478 a, c dbSNP:767739457
486 486 c, g dbSNP:775896862
492 492 c, t dbSNP:201725825
493 493 a, g dbSNP:764594848
495 495 c, g dbSNP:753847903
506 506 c, t dbSNP:191240032
507 507 a, g dbSNP:765448984
519 519 a, g dbSNP:58280059
534 534 a, g dbSNP:758493011
551 551 c, t dbSNP:766713154
565 565 a, g dbSNP:780065997
567 567 c, t dbSNP:751364520
568 568 a, g dbSNP:754845817
581 581 a, t dbSNP:781185157
582 582 a, g dbSNP:752652573
583 583 a, g dbSNP:756140607
600 600 c, t dbSNP:777131735
603 603 c, g dbSNP:144641798
606 606 c, t dbSNP:138201631
607 607 a, g dbSNP:377123780
613 613 c, t dbSNP:747323948
620 620 a, c dbSNP:540073928
630 630 a, c, g dbSNP:777018900
636 636 g, t dbSNP:770348553
648 648 c, t dbSNP:771771961
654 654 c, t dbSNP:781479853
658 658 a, g dbSNP:748550381
664 664 a, g, t dbSNP:529768244
667 667 g, t dbSNP:749694206
669 669 a, g dbSNP:763423158
674 674 a, g dbSNP:771107075
681 681 c, t dbSNP:774642632
684 684 c, t dbSNP:759815398
686 686 c, t dbSNP:543030829
687 687 a, g dbSNP:139862632
696 696 c, t dbSNP:111277749
697 697 a, g dbSNP:760546011
704 704 c, t dbSNP:111540940
710 710 a, g dbSNP:753791195
718 718 a, c, g dbSNP:544714733
722 722 a, g dbSNP:749950720
757 757 c, t dbSNP:201835306
758 758 a, g dbSNP:765859442
759 759 c, t dbSNP:538246934
760 760 a, g dbSNP:754656921
765 765 a, c dbSNP:778189721
775 775 g, t dbSNP:749680221
777 777 c, t dbSNP:757770420
784 784 a, g, t dbSNP:139133423
794 794 -, a dbSNP:71445558
796 796 -, a dbSNP:749630753
805 805 c, t dbSNP:150631941
812 812 -, g dbSNP:771889973
813 813 a, g, t dbSNP:554937672
813 813 -, g dbSNP:775259976
814 814 a, c, g, t dbSNP:145077856
815 815 a, c, g, t dbSNP:776421832
818 818 a, g dbSNP:773112716
821 821 a, g dbSNP:762922297
824 824 a, g dbSNP:372262254
829 829 -, a dbSNP:768044419
839 839 -, t dbSNP:776136452
840 840 a, g dbSNP:765912648
848 848 a, c dbSNP:148698157
849 849 c, t dbSNP:759174174
850 850 a, g dbSNP:142271678
856 856 a, c, g, t dbSNP:571588910
858 858 c, t dbSNP:558605071
864 864 c, g, t dbSNP:147887880
865 865 a, g dbSNP:201108880
870 870 a, g dbSNP:141555810
876 876 a, c dbSNP:749044025
882 882 c, t dbSNP:565642382
883 883 g, t dbSNP:534531260
888 888 g, t dbSNP:759563266
891 891 a, c, t dbSNP:771673604
918 918 c, t dbSNP:760390936
925 925 c, t dbSNP:763851306
926 926 a, g dbSNP:372053825
929 929 a, c dbSNP:763250692
933 933 c, t dbSNP:766818746
934 934 a, g dbSNP:751980357
937 937 c, t dbSNP:755579750
941 941 a, t dbSNP:376029750
950 950 a, g dbSNP:752792758
953 953 a, g dbSNP:756266195
965 965 a, t dbSNP:1062136
967 967 c, t dbSNP:202226446
968 968 a, g dbSNP:749059028
972 972 c, t dbSNP:147049749
973 973 a, g dbSNP:756978401
976 976 g, t dbSNP:778805131
978 978 c, t dbSNP:370850207
979 979 c, t dbSNP:767381323
980 980 a, g dbSNP:775082307
982 982 g, t dbSNP:746521872
989 989 c, t dbSNP:768374581
991 991 a, c, t dbSNP:776126532
992 992 a, g dbSNP:766650595
995 995 c, t dbSNP:774840012
999 999 c, t dbSNP:759981145
1005 1005 c, t dbSNP:112460655
1017 1017 c, g dbSNP:768020372
1026 1026 a, g dbSNP:141025702
1035 1035 a, g dbSNP:752737734
1043 1043 a, c dbSNP:769503071
1045 1045 a, g, t dbSNP:546693939
1054 1054 c, t dbSNP:772515139
1057 1057 a, g dbSNP:775949935
1062 1062 a, g dbSNP:201721832
1068 1068 c, t dbSNP:568437854
1069 1069 a, g dbSNP:764073001
1081 1081 a, g dbSNP:201023185
1082 1082 c, t dbSNP:551054294
1083 1083 a, c, g dbSNP:182362882
1085 1085 c, g dbSNP:758039402
1086 1086 g, t dbSNP:780035440
1088 1088 a, g dbSNP:751540537
1095 1095 a, c, g dbSNP:150253385
1098 1098 -, gc dbSNP:773035280
1100 1100 a, c, t dbSNP:372769067
1101 1101 a, g dbSNP:769295295
1107 1107 a, g dbSNP:777507942
1108 1108 c, g dbSNP:748985887
1111 1111 c, t dbSNP:772390903
1123 1123 a, g dbSNP:775896971
1130 1130 c, t dbSNP:200738174
1135 1135 a, c, t dbSNP:761154464
1146 1146 c, t dbSNP:138931620
1153 1153 c, t dbSNP:149442966
1158 1158 c, t dbSNP:765328106
1162 1162 c, t dbSNP:201705553
1164 1164 c, t dbSNP:750644484
1173 1173 g, t dbSNP:763334012
1182 1182 c, t dbSNP:766266356
1192 1192 a, g dbSNP:751415641
1197 1197 a, g dbSNP:754808238
1208 1208 c, t dbSNP:550022818
1209 1209 c, g, t dbSNP:199811756
1210 1210 a, g dbSNP:777079274
1212 1212 a, g dbSNP:764022056
1221 1221 a, g dbSNP:753304028
1224 1224 a, g dbSNP:756781003
1242 1242 c, t dbSNP:764776351
1243 1243 a, g dbSNP:750085443
1244 1244 c, t dbSNP:374377652
1246 1246 a, g dbSNP:144598865
1257 1257 c, t dbSNP:138505396
1261 1261 a, c dbSNP:368435076
1263 1263 a, g dbSNP:778449798
1265 1265 c, g dbSNP:749863724
1277 1277 c, t dbSNP:771107373
1278 1278 a, g dbSNP:141556759
1281 1281 c, t dbSNP:746086528
1290 1290 c, t dbSNP:772193708
1308 1308 a, g dbSNP:775286182
1312 1312 c, t dbSNP:760416164
1317 1317 a, c dbSNP:547207199
1318 1318 a, g dbSNP:776526118
1320 1320 a, g dbSNP:761778133
1325 1325 a, g dbSNP:764713289
1329 1329 c, t dbSNP:371851241
1336 1336 c, g dbSNP:201405479
1339 1339 a, g dbSNP:765981127
1341 1341 a, c, t dbSNP:753058436
1344 1344 c, t dbSNP:536321330
1348 1348 c, g dbSNP:754387972
1349 1349 c, t dbSNP:757893333
1350 1350 a, g dbSNP:778990792
1362 1362 c, g dbSNP:759333754
1380 1380 a, g dbSNP:764536284
1401 1401 -, tgg dbSNP:751776846
1405 1405 a, g dbSNP:754265114
1418 1418 c, t dbSNP:371493214
1419 1419 a, g dbSNP:190914158
1422 1422 a, g dbSNP:1064933
1425 1425 c, t dbSNP:750466695
1428 1428 a, c dbSNP:758384827
1429 1429 c, t dbSNP:199724286
1430 1430 a, g dbSNP:747227657
1434 1434 a, g dbSNP:755207315
1435 1435 c, t dbSNP:780899853
1440 1440 c, t dbSNP:747970101
1441 1441 a, g dbSNP:769724893
1446 1446 c, g, t dbSNP:201939387
1452 1452 a, g dbSNP:770346038
1465 1465 a, g dbSNP:671
1470 1470 a, g dbSNP:569388000
1471 1471 a, c dbSNP:767280255
1503 1503 c, t dbSNP:775259939
1506 1506 a, g dbSNP:760414925
1510 1510 a, g dbSNP:765515172
1517 1517 a, g dbSNP:199997803
1521 1521 a, g dbSNP:187335908
1522 1522 c, t dbSNP:763302651
1536 1536 c, t dbSNP:540182020
1538 1538 c, t dbSNP:751588480
1545 1545 a, g dbSNP:759588558
1547 1547 a, g dbSNP:375668624
1552 1552 a, g dbSNP:369765587
1588 1588 c, t dbSNP:370433121
1590 1590 c, g dbSNP:755554206
1624 1624 -, a dbSNP:574551187
1636 1636 a, g dbSNP:113787291
1662 1662 c, t dbSNP:58352818
1723 1723 a, g dbSNP:548292659
1737 1737 c, t dbSNP:561559310
1786 1786 -, cgctt dbSNP:572001362
1787 1787 c, t dbSNP:192282635
1801 1801 c, t dbSNP:77603030
1802 1802 a, g dbSNP:552684652
1808 1808 a, g dbSNP:553112128
1827 1827 c, t dbSNP:572829790
1856 1856 a, t dbSNP:571106658
1867 1867 c, t dbSNP:185494407
1872 1872 g, t dbSNP:770699571
1907 1907 g, t dbSNP:778739435

Target ORF information:

RefSeq Version NM_001204889
Organism Homo sapiens (human)
Definition Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204889

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG CCTTGGAGAC CCTGGACAAT
GGCAAGCCCT ATGTCATCTC CTACCTGGTG GATTTGGACA TGGTCCTCAA ATGTCTCCGG
TATTATGCCG GCTGGGCTGA TAAGTACCAC GGGAAAACCA TCCCCATTGA CGGAGACTTC
TTCAGCTACA CACGCCATGA ACCTGTGGGG GTGTGCGGGC AGATCATTCC GTGGAATTTC
CCGCTCCTGA TGCAAGCATG GAAGCTGGGC CCAGCCTTGG CAACTGGAAA CGTGGTTGTG
ATGAAGGTAG CTGAGCAGAC ACCCCTCACC GCCCTCTATG TGGCCAACCT GATCAAGGAG
GCTGGCTTTC CCCCTGGTGT GGTCAACATT GTGCCTGGAT TTGGCCCCAC GGCTGGGGCC
GCCATTGCCT CCCATGAGGA TGTGGACAAA GTGGCATTCA CAGGCTCCAC TGAGATTGGC
CGCGTAATCC AGGTTGCTGC TGGGAGCAGC AACCTCAAGA GAGTGACCTT GGAGCTGGGG
GGGAAGAGCC CCAACATCAT CATGTCAGAT GCCGATATGG ATTGGGCCGT GGAACAGGCC
CACTTCGCCC TGTTCTTCAA CCAGGGCCAG TGCTGCTGTG CCGGCTCCCG GACCTTCGTG
CAGGAGGACA TCTATGATGA GTTTGTGGAG CGGAGCGTTG CCCGGGCCAA GTCTCGGGTG
GTCGGGAACC CCTTTGATAG CAAGACCGAG CAGGGGCCGC AGGTGGATGA AACTCAGTTT
AAGAAGATCC TCGGCTACAT CAACACGGGG AAGCAAGAGG GGGCGAAGCT GCTGTGTGGT
GGGGGCATTG CTGCTGACCG TGGTTACTTC ATCCAGCCCA CTGTGTTTGG AGATGTGCAG
GATGGCATGA CCATCGCCAA GGAGGAGATC TTCGGGCCAG TGATGCAGAT CCTGAAGTTC
AAGACCATAG AGGAGGTTGT TGGGAGAGCC AACAATTCCA CGTACGGGCT GGCCGCAGCT
GTCTTCACAA AGGATTTGGA CAAGGCCAAT TACCTGTCCC AGGCCCTCCA GGCGGGCACT
GTGTGGGTCA ACTGCTATGA TGTGTTTGGA GCCCAGTCAC CCTTTGGTGG CTACAAGATG
TCGGGGAGTG GCCGGGAGTT GGGCGAGTAC GGGCTGCAGG CATACACTGA AGTGAAAACT
GTCACAGTCA AAGTGCCTCA GAAGAACTCA TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.