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FGF3 fibroblast growth factor 3 [Homo sapiens (human)]

Gene Symbol FGF3
Entrez Gene ID 2248
Full Name fibroblast growth factor 3
Synonyms HBGF-3, INT2
General protein information
Preferred Names
fibroblast growth factor 3
Names
fibroblast growth factor 3
FGF-3
oncogene INT2
proto-oncogene Int-2
INT-2 proto-oncogene protein
heparin-binding growth factor 3
murine mammary tumor virus integration site 2, mouse
V-INT2 murine mammary tumor virus integration site oncogene homolog
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

164950

Disorder Html: Deafness, congenital with inner ear agenesis, microtia, and





The following FGF3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18680 NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18680
Accession Version NM_005247.2
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product fibroblast growth factor 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X14445.1. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2001 this sequence version replaced gi:4885232. Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC113739.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGGCCTAA TCTGGCTGCT ACTGCTCAGC CTGCTGGAGC CCGGCTGGCC CGCAGCGGGC 
CCTGGGGCGC GGTTGCGGCG CGATGCGGGC GGCCGTGGCG GCGTCTACGA GCACCTTGGC
GGGGCGCCCC GGCGCCGCAA GCTCTACTGC GCCACGAAGT ACCACCTCCA GCTGCACCCG
AGCGGCCGCG TCAACGGCAG CCTGGAGAAC AGCGCCTACA GTATTTTGGA GATAACGGCA
GTGGAGGTGG GCATTGTGGC CATCAGGGGT CTCTTCTCCG GGCGGTACCT GGCCATGAAC
AAGAGGGGAC GACTCTATGC TTCGGAGCAC TACAGCGCCG AGTGCGAGTT TGTGGAGCGG
ATCCACGAGC TGGGCTATAA TACGTATGCC TCCCGGCTGT ACCGGACGGT GTCTAGTACG
CCTGGGGCCC GCCGGCAGCC CAGCGCCGAG AGACTGTGGT ACGTGTCTGT GAACGGCAAG
GGCCGGCCCC GCAGGGGCTT CAAGACCCGC CGCACACAGA AGTCCTCCCT GTTCCTGCCC
CGCGTGCTGG ACCACAGGGA CCACGAGATG GTGCGGCAGC TACAGAGTGG GCTGCCCAGA
CCCCCTGGTA AGGGGGTCCA GCCCCGACGG CGGCGGCAGA AGCAGAGCCC GGATAACCTG
GAGCCCTCTC ACGTTCAGGC TTCGAGACTG GGCTCCCAGC TGGAGGCCAG TGCGCACTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_005238.1
CDS492..1211
Misc Feature(1)627..1034(+)
Misc Feature(2)627..1034(+)
Misc Feature(3)963..1013(+)
Exon (1)1..711
Gene:FGF3
Gene Synonym:
Exon (2)712..815
Gene:FGF3
Gene Synonym:
Exon (3)816..1548
Gene:FGF3
Gene Synonym:
Translation
Position Chain Variation Link
318 318 c, g dbSNP:12418223
508 508 c, t dbSNP:121917706
560 560 g, t dbSNP:41538178
637 637 a, g dbSNP:281860300
641 641 a, c dbSNP:281860301
687 687 g, t dbSNP:121917705
736 736 a, g dbSNP:146864055
742 742 -, g dbSNP:142716324
746 746 -, t dbSNP:281860302
774 774 c, t dbSNP:281860303
801 801 c, t dbSNP:121917704
808 808 a, g dbSNP:281860306
831 831 a, c, g dbSNP:147952743
836 836 c, g, t dbSNP:116162988
837 837 a, c, g dbSNP:79472069
885 885 -, c dbSNP:281860304
899 899 a, g dbSNP:35420992
948 948 -, tg dbSNP:281860307
957 957 c, t dbSNP:121917703
1009 1009 a, t dbSNP:7110221
1055 1055 a, c, t dbSNP:113473565
1076 1076 g, t dbSNP:115545058
1081 1081 a, g dbSNP:754817690
1107 1107 -, g dbSNP:281860305
1120 1120 a, g dbSNP:115452181
1162 1162 a, c dbSNP:751354293
1256 1256 a, g dbSNP:758169085

Target ORF information:

RefSeq Version NM_005247
Organism Homo sapiens (human)
Definition Homo sapiens fibroblast growth factor 3 (FGF3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005247

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGGCCTAA TCTGGCTGCT ACTGCTCAGC CTGCTGGAGC CCGGCTGGCC CGCAGCGGGC 
CCTGGGGCGC GGTTGCGGCG CGATGCGGGC GGCCGTGGCG GCGTCTACGA GCACCTTGGC
GGGGCGCCCC GGCGCCGCAA GCTCTACTGC GCCACGAAGT ACCACCTCCA GCTGCACCCG
AGCGGCCGCG TCAACGGCAG CCTGGAGAAC AGCGCCTACA GTATTTTGGA GATAACGGCA
GTGGAGGTGG GCATTGTGGC CATCAGGGGT CTCTTCTCCG GGCGGTACCT GGCCATGAAC
AAGAGGGGAC GACTCTATGC TTCGGAGCAC TACAGCGCCG AGTGCGAGTT TGTGGAGCGG
ATCCACGAGC TGGGCTATAA TACGTATGCC TCCCGGCTGT ACCGGACGGT GTCTAGTACG
CCTGGGGCCC GCCGGCAGCC CAGCGCCGAG AGACTGTGGT ACGTGTCTGT GAACGGCAAG
GGCCGGCCCC GCAGGGGCTT CAAGACCCGC CGCACACAGA AGTCCTCCCT GTTCCTGCCC
CGCGTGCTGG ACCACAGGGA CCACGAGATG GTGCGGCAGC TACAGAGTGG GCTGCCCAGA
CCCCCTGGTA AGGGGGTCCA GCCCCGACGG CGGCGGCAGA AGCAGAGCCC GGATAACCTG
GAGCCCTCTC ACGTTCAGGC TTCGAGACTG GGCTCCCAGC TGGAGGCCAG TGCGCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.