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FGFR2 fibroblast growth factor receptor 2 [Homo sapiens (human)]

Gene Symbol FGFR2
Entrez Gene ID 2263
Full Name fibroblast growth factor receptor 2
Synonyms BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
General protein information
Preferred Names
fibroblast growth factor receptor 2
Names
fibroblast growth factor receptor 2
FGFR-2
FGF receptor
soluble FGFR4 variant 4
bacteria-expressed kinase
hydroxyaryl-protein kinase
keratinocyte growth factor receptor
BEK fibroblast growth factor receptor
protein tyrosine kinase, receptor like 14
NP_000132.3
NP_001138385.1
NP_001138386.1
NP_001138387.1
NP_001138388.1
NP_001138389.1
NP_001138390.1
NP_001138391.1
NP_075259.4
NP_075418.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q26

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. lac of sum
Disorder MIM:

176943

Disorder Html: Crouzon syndrome, 123500 (3); Jackson-Weiss syndrome, 123150 (3); Beare-Stevenson cutis gyrata syndrome, 123790 (3); Pfeiffer syndrome, 101600
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu27185 NM_022970 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu22945 NM_001144913 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu27162 NM_001144918 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 8, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu22401 NM_001144919 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 9, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu26260 NM_000141 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu27093 NM_001144914 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 4, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu26187 NM_001144916 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 6, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu26708 NM_001144917 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 7, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu22621 NM_023029 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 11, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu26352 NM_001144915 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 5, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu44132 XM_006717708 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu44133 XM_006717709 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X2, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu44134 XM_006717710 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X3, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu44135 XM_006717711 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X4, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu44136 XM_006717712 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X5, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu57774 XM_011539510 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X6, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu44137 XM_006717713 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X7, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu27185D
Sequence Information ORF Nucleotide Sequence (Length: 2469bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product fibroblast growth factor receptor 2 isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039243.1, CN345547.1, M55614.1, M80634.1, BC037338.2 and CB305736.1. This sequence is a reference standard in the RefSeqGene project. On May 24, 2008 this sequence version replaced gi:108773805. Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1. Sequence Note: A downstream AUG translation start codon is selected for this RefSeq based on the presence of a strong Kozak consensus signal, a strong community standard for the use of the downstream start codon, and on a higher probability of an N-terminal signal peptide being present in the resulting protein. The use of an alternative in-frame upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. Translation from the annotated downstream start codon is likely to occur via leaky scanning and/or reinitiation. CCDS Note: A downstream AUG translation start codon is selected for this CCDS representation based on a strong community standard for its use, and on a higher probability of a signal peptide being present in the protein N-terminus. The use of an alternative upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. The upstream AUG has a weak Kozak signal while the downstream AUG has a strong Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream AUG. The presence of multiple upstream ORFs suggests that a combination of leaky scanning and translational reinitiation may be necessary to achieve translation of the annotated ORF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M80634.1, M97193.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID: 15863034) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA GCCACCAACC
AAATACCAAA TCTCTCAACC AGAAGTGTAC GTGGCTGCGC CAGGGGAGTC GCTAGAGGTG
CGCTGCCTGT TGAAAGATGC CGCCGTGATC AGTTGGACTA AGGATGGGGT GCACTTGGGG
CCCAACAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAGGGCGC CACGCCTAGA
GACTCCGGCC TCTATGCTTG TACTGCCAGT AGGACTGTAG ACAGTGAAAC TTGGTACTTC
ATGGTGAATG TCACAGATGC CATCTCATCC GGAGATGATG AGGATGACAC CGATGGTGCG
GAAGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA
AAGATGGAAA AGCGGCTCCA TGCTGTGCCT GCGGCCAACA CTGTCAAGTT TCGCTGCCCA
GCCGGGGGGA ACCCAATGCC AACCATGCGG TGGCTGAAAA ACGGGAAGGA GTTTAAGCAG
GAGCATCGCA TTGGAGGCTA CAAGGTACGA AACCAGCACT GGAGCCTCAT TATGGAAAGT
GTGGTCCCAT CTGACAAGGG AAATTATACC TGTGTAGTGG AGAATGAATA CGGGTCCATC
AATCACACGT ACCACCTGGA TGTTGTGGAG CGATCGCCTC ACCGGCCCAT CCTCCAAGCC
GGACTGCCGG CAAATGCCTC CACAGTGGTC GGAGGAGACG TAGAGTTTGT CTGCAAGGTT
TACAGTGATG CCCAGCCCCA CATCCAGTGG ATCAAGCACG TGGAAAAGAA CGGCAGTAAA
TACGGGCCCG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC
AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACCGAGGCGG ATGCTGGGGA ATATATATGT
AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCAAAA
CAGCAAGCGC CTGGAAGAGA AAAGGAGATT ACAGCTTCCC CAGACTACCT GGAGATAGCC
ATTTACTGCA TAGGGGTCTT CTTAATCGCC TGTATGGTGG TAACAGTCAT CCTGTGCCGA
ATGAAGAACA CGACCAAGAA GCCAGACTTC AGCAGCCAGC CGGCTGTGCA CAAGCTGACC
AAACGTATCC CCCTGCGGAG ACAGGTAACA GTTTCGGCTG AGTCCAGCTC CTCCATGAAC
TCCAACACCC CGCTGGTGAG GATAACAACA CGCCTCTCTT CAACGGCAGA CACCCCCATG
CTGGCAGGGG TCTCCGAGTA TGAACTTCCA GAGGACCCAA AATGGGAGTT TCCAAGAGAT
AAGCTGACAC TGGGCAAGCC CCTGGGAGAA GGTTGCTTTG GGCAAGTGGT CATGGCGGAA
GCAGTGGGAA TTGACAAAGA CAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGTTG
AAAGATGATG CCACAGAGAA AGACCTTTCT GATCTGGTGT CAGAGATGGA GATGATGAAG
ATGATTGGGA AACACAAGAA TATCATAAAT CTTCTTGGAG CCTGCACACA GGATGGGCCT
CTCTATGTCA TAGTTGAGTA TGCCTCTAAA GGCAACCTCC GAGAATACCT CCGAGCCCGG
AGGCCACCCG GGATGGAGTA CTCCTATGAC ATTAACCGTG TTCCTGAGGA GCAGATGACC
TTCAAGGACT TGGTGTCATG CACCTACCAG CTGGCCAGAG GCATGGAGTA CTTGGCTTCC
CAAAAATGTA TTCATCGAGA TTTAGCAGCC AGAAATGTTT TGGTAACAGA AAACAATGTG
ATGAAAATAG CAGACTTTGG ACTCGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG
ACCACCAATG GGCGGCTTCC AGTCAAGTGG ATGGCTCCAG AAGCCCTGTT TGATAGAGTA
TACACTCATC AGAGTGATGT CTGGTCCTTC GGGGTGTTAA TGTGGGAGAT CTTCACTTTA
GGGGGCTCGC CCTACCCAGG GATTCCCGTG GAGGAACTTT TTAAGCTGCT GAAGGAAGGA
CACAGAATGG ATAAGCCAGC CAACTGCACC AACGAACTGT ACATGATGAT GAGGGACTGT
TGGCATGCAG TGCCCTCCCA GAGACCAACG TTCAAGCAGT TGGTAGAAGA CTTGGATCGA
ATTCTCACTC TCACAACCAA TGAGGAATAC TTGGACCTCA GCCAACCTCT CGAACAGTAT
TCACCTAGTT ACCCTGACAC AAGAAGTTCT TGTTCTTCAG GAGATGATTC TGTTTTTTCT
CCAGACCCCA TGCCTTACGA ACCATGCCTT CCTCAGTATC CACACATAAA CGGCAGTGTT
AAAACATGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_075259.4
CDS648..3116
Misc Feature(1)531..533(+)
Misc Feature(2)591..593(+)
Misc Feature(3)786..1019(+)
Misc Feature(4)807..977(+)
Misc Feature(5)1137..1391(+)
Misc Feature(6)1143..1157(+)
Misc Feature(7)1146..1181(+)
Misc Feature(8)1164..1361(+)
Misc Feature(9)1434..1718(+)
Misc Feature(10)1458..1721(+)
Misc Feature(11)1485..1679(+)
Misc Feature(12)2016..2954(+)
Misc Feature(13)2091..2921(+)
Misc Feature(14)2109..2777(+)
Misc Feature(15)2109..2582(+)
Misc Feature(16)2526..2777(+)
Misc Feature(17)2577..2654(+)
Exon (1)1..497
Gene:FGFR2
Gene Synonym:
Exon (2)498..756
Gene:FGFR2
Gene Synonym:
Exon (3)757..1023
Gene:FGFR2
Gene Synonym:
Exon (4)1024..1101
Gene:FGFR2
Gene Synonym:
Exon (5)1102..1271
Gene:FGFR2
Gene Synonym:
Exon (6)1272..1395
Gene:FGFR2
Gene Synonym:
Exon (7)1396..1586
Gene:FGFR2
Gene Synonym:
Exon (8)1587..1734
Gene:FGFR2
Gene Synonym:
Exon (9)1735..1937
Gene:FGFR2
Gene Synonym:
Exon (10)1938..2089
Gene:FGFR2
Gene Synonym:
Exon (11)2090..2211
Gene:FGFR2
Gene Synonym:
Exon (12)2212..2322
Gene:FGFR2
Gene Synonym:
Exon (13)2323..2513
Gene:FGFR2
Gene Synonym:
Exon (14)2514..2636
Gene:FGFR2
Gene Synonym:
Exon (15)2637..2707
Gene:FGFR2
Gene Synonym:
Exon (16)2708..2845
Gene:FGFR2
Gene Synonym:
Exon (17)2846..2951
Gene:FGFR2
Gene Synonym:
Exon (18)2952..4643
Gene:FGFR2
Gene Synonym:
Translation
Position Chain Variation Link
22 22 a, c dbSNP:549524538
77 77 c, t dbSNP:41301041
190 190 a, c dbSNP:41301043
227 227 c, t dbSNP:567128020
252 252 c, g dbSNP:547319962
277 277 a, c, g dbSNP:527570655
289 289 c, t dbSNP:564784147
290 290 c, t dbSNP:41301545
296 296 c, t dbSNP:772658678
311 311 a, g dbSNP:531721871
330 330 c, g dbSNP:41301547
351 351 -, cc dbSNP:41301549
410 410 c, t dbSNP:542734413
412 412 a, c, g dbSNP:1047111
475 475 a, g dbSNP:540975865
491 491 a, g dbSNP:41258305
501 501 c, t dbSNP:769814958
509 509 a, g dbSNP:574834089
513 513 c, t dbSNP:554557891
520 520 a, g dbSNP:547739869
540 540 c, t dbSNP:540720034
541 541 g, t dbSNP:761776466
552 552 g, t dbSNP:775497340
557 557 g, t dbSNP:769902826
558 558 c, t dbSNP:759690410
559 559 a, c, g dbSNP:771307977
561 561 a, g dbSNP:747423954
566 566 c, t dbSNP:778082131
570 570 g, t dbSNP:772523670
572 572 c, t dbSNP:748677100
573 573 c, t dbSNP:41287990
574 574 a, g dbSNP:4647922
576 576 -, agaggaagt dbSNP:780553051
577 577 a, g dbSNP:748929124
582 582 a, g dbSNP:779800206
586 586 -, t dbSNP:770287475
587 587 g, t dbSNP:3135721
601 601 c, t dbSNP:755803072
602 602 a, g dbSNP:201606812
607 607 a, c dbSNP:767413285
611 611 c, g dbSNP:757197396
617 617 c, t dbSNP:751455486
624 624 a, g dbSNP:765236201
628 628 c, t dbSNP:759620495
629 629 a, g dbSNP:776670842
631 631 c, g dbSNP:766629665
636 636 g, t dbSNP:760884709
641 641 c, t dbSNP:773626594
642 642 a, g dbSNP:772427122
645 645 a, c dbSNP:748610621
648 648 a, g dbSNP:774885289
662 662 c, t dbSNP:768068971
663 663 c, t dbSNP:141724446
664 664 a, c, g dbSNP:3750819
670 670 g, t dbSNP:147307031
671 671 c, t dbSNP:781146007
675 675 c, g dbSNP:370122049
680 680 c, g, t dbSNP:200562301
681 681 a, g dbSNP:143978938
688 688 c, t dbSNP:753987054
697 697 c, t dbSNP:766435280
703 703 c, t dbSNP:760903123
709 709 c, t dbSNP:773358865
711 711 c, t dbSNP:377570596
712 712 a, g dbSNP:189010277
715 715 a, c dbSNP:774554190
716 716 c, t dbSNP:769243397
734 734 a, g dbSNP:749806452
741 741 a, g dbSNP:775194870
743 743 a, g dbSNP:769369328
747 747 c, g dbSNP:373546701
752 752 a, g dbSNP:780856634
755 755 a, g dbSNP:770654393
759 759 c, t dbSNP:775973432
761 761 a, g dbSNP:370046872
766 766 c, t dbSNP:746629822
774 774 a, c dbSNP:777638930
776 776 a, c dbSNP:771790476
785 785 a, c dbSNP:748117555
788 788 a, g dbSNP:778777292
790 790 a, c dbSNP:200700308
797 797 c, t dbSNP:376622125
805 805 c, t dbSNP:371358242
806 806 a, g, t dbSNP:1047102
807 807 c, t dbSNP:151126801
817 817 c, t dbSNP:56226109
818 818 a, g dbSNP:753279848
829 829 a, g dbSNP:199575491
840 840 a, g dbSNP:760115258
843 843 a, g dbSNP:148514974
847 847 c, t dbSNP:145746586
848 848 c, t dbSNP:200386134
849 849 a, g dbSNP:374996878
850 850 c, t dbSNP:537841180
851 851 c, g dbSNP:747982371
852 852 a, g dbSNP:371714070
855 855 a, g dbSNP:768650541
869 869 a, g dbSNP:367962518
875 875 a, g dbSNP:781348632
876 876 a, g dbSNP:757219761
878 878 a, g dbSNP:747287641
881 881 c, t dbSNP:778093907
882 882 c, t dbSNP:758671612
889 889 c, t dbSNP:753179677
894 894 a, g dbSNP:765682593
895 895 a, g dbSNP:748315048
896 896 c, t dbSNP:755520875
898 898 g, t dbSNP:144714823
899 899 a, g dbSNP:779848635
910 910 c, t dbSNP:200369248
926 926 a, g dbSNP:760052114
935 935 c, t dbSNP:55806379
936 936 a, g dbSNP:372430349
941 941 a, g dbSNP:1047101
946 946 a, g dbSNP:774193926
953 953 c, t dbSNP:368662264
956 956 c, t dbSNP:749255726
957 957 c, t dbSNP:775253363
983 983 c, t dbSNP:771065999
1000 1000 a, g, t dbSNP:139263005
1007 1007 a, c dbSNP:758751243
1009 1009 c, t dbSNP:748322657
1011 1011 a, g dbSNP:779423644
1015 1015 a, g dbSNP:375935265
1022 1022 a, t dbSNP:754388941
1034 1034 a, t dbSNP:749651751
1038 1038 a, g dbSNP:780458049
1040 1040 a, g dbSNP:756641429
1045 1045 a, t dbSNP:750876096
1046 1046 c, g, t dbSNP:373155033
1048 1048 a, t dbSNP:751236652
1058 1058 c, t dbSNP:763704465
1065 1065 a, g dbSNP:762636391
1066 1066 c, t dbSNP:752501698
1067 1067 a, g dbSNP:765024365
1068 1068 a, g dbSNP:759550441
1084 1084 a, g dbSNP:776668623
1089 1089 a, g dbSNP:772298926
1096 1096 a, g dbSNP:762030875
1097 1097 -, caa dbSNP:752218106
1100 1100 c, g dbSNP:774538633
1103 1103 a, g dbSNP:763094016
1104 1104 a, g dbSNP:775743948
1116 1116 a, g dbSNP:770169545
1120 1120 a, g dbSNP:112880592
1124 1124 a, g dbSNP:746281842
1141 1141 a, g dbSNP:146244307
1145 1145 c, t dbSNP:777075226
1148 1148 c, t dbSNP:766869457
1160 1160 a, g dbSNP:747502119
1180 1180 a, g dbSNP:141796960
1184 1184 c, t dbSNP:139617492
1190 1190 c, t dbSNP:150598483
1191 1191 a, g, t dbSNP:200766273
1196 1196 g, t dbSNP:753750519
1198 1198 a, t dbSNP:202212545
1199 1199 a, c, g dbSNP:750312209
1203 1203 a, g dbSNP:55977237
1204 1204 c, t dbSNP:755793
1208 1208 a, g dbSNP:775411475
1213 1213 c, t dbSNP:761753706
1215 1215 c, t dbSNP:147987917
1216 1216 a, g dbSNP:759750319
1222 1222 a, t dbSNP:777039355
1229 1229 c, t dbSNP:771218136
1255 1255 a, g dbSNP:747502397
1263 1263 a, g dbSNP:773718005
1313 1313 a, c dbSNP:755490768
1322 1322 c, g dbSNP:537758598
1330 1330 a, t dbSNP:146948953
1333 1333 a, t dbSNP:368224180
1343 1343 a, g, t dbSNP:1047100
1346 1346 a, g dbSNP:748983200
1347 1347 c, g dbSNP:779806520
1358 1358 c, t dbSNP:769311722
1362 1362 a, t dbSNP:555207905
1363 1363 c, t dbSNP:780846065
1365 1365 a, g dbSNP:757276690
1367 1367 c, g dbSNP:751395138
1374 1374 a, g dbSNP:778994181
1375 1375 c, t dbSNP:755001161
1376 1376 a, g dbSNP:199890227
1397 1397 a, g dbSNP:771784064
1398 1398 a, c dbSNP:748113099
1402 1402 cgc, tct dbSNP:281865420
1402 1402 cg, tt dbSNP:121918498
1402 1402 c, g, t dbSNP:79184941
1403 1403 ctt, gcc dbSNP:387907372
1403 1403 a, g dbSNP:138769323
1405 1405 c, g dbSNP:77543610
1406 1406 g, t dbSNP:3135755
1410 1410 c, t dbSNP:149200230
1412 1412 c, g dbSNP:200759234
1419 1419 c, t dbSNP:747171741
1427 1427 c, t dbSNP:778288494
1433 1433 a, g, t dbSNP:753082618
1435 1435 c, t dbSNP:779326224
1436 1436 a, g dbSNP:138315382
1446 1446 c, t dbSNP:121918505
1448 1448 c, t dbSNP:753345992
1451 1451 a, g dbSNP:765814642
1457 1457 a, c, t dbSNP:150488750
1458 1458 a, g dbSNP:183250272
1460 1460 a, g dbSNP:761649011
1464 1464 -, gac dbSNP:121918503
1466 1466 c, g, t dbSNP:140427785
1477 1477 c, t dbSNP:762937564
1480 1480 g, t dbSNP:776587763
1484 1484 a, g dbSNP:771068222
1499 1499 c, g dbSNP:747267954
1503 1503 c, t dbSNP:778094013
1505 1505 a, c dbSNP:772391649
1513 1513 a, c dbSNP:121918497
1515 1515 c, g, t dbSNP:121918501
1517 1517 c, g, t dbSNP:121918499
1521 1521 a, g dbSNP:121918500
1524 1524 c, t dbSNP:748526473
1526 1526 c, t dbSNP:55745510
1527 1527 a, g dbSNP:755453106
1538 1538 c, t dbSNP:754300987
1539 1539 a, g dbSNP:779566502
1546 1546 a, g dbSNP:755570604
1550 1550 c, t dbSNP:768862267
1553 1553 g, t dbSNP:532964975
1555 1555 c, g dbSNP:374608214
1556 1556 c, t dbSNP:761525014
1557 1557 a, g dbSNP:370877537
1559 1559 c, t dbSNP:570589620
1563 1563 c, g dbSNP:199937788
1565 1565 a, g dbSNP:762804005
1571 1571 c, t dbSNP:775459922
1572 1572 c, t dbSNP:4647921
1576 1576 a, g dbSNP:121913475
1578 1578 a, g dbSNP:771158421
1588 1588 a, g dbSNP:3206759
1592 1592 a, g dbSNP:749699527
1594 1594 g, t dbSNP:1129324
1595 1595 a, g dbSNP:775831408
1596 1596 a, g, t dbSNP:1143401
1603 1603 a, g dbSNP:770347175
1609 1609 a, c dbSNP:1129323
1610 1610 g, t dbSNP:1129322
1616 1616 a, g dbSNP:369682344
1618 1618 a, t dbSNP:1129321
1619 1619 a, g, t dbSNP:756750786
1620 1620 a, c dbSNP:1129320
1626 1626 c, g dbSNP:563769835
1628 1628 a, g dbSNP:1143402
1633 1633 a, g dbSNP:777532382
1637 1637 a, g dbSNP:1129318
1640 1640 c, t dbSNP:752595302
1645 1645 a, c, t dbSNP:1047095
1646 1646 a, g dbSNP:768008676
1649 1649 c, t dbSNP:1047090
1658 1658 a, g dbSNP:753784222
1663 1663 c, t dbSNP:1047088
1664 1664 a, g dbSNP:1047087
1672 1672 g, t dbSNP:1065581
1681 1681 a, c dbSNP:1047083
1682 1682 c, t dbSNP:187206427
1685 1685 a, t dbSNP:1047082
1689 1689 a, c dbSNP:1065582
1691 1691 g, t dbSNP:1047078
1696 1696 a, t dbSNP:1047077
1700 1700 c, g dbSNP:1047076
1704 1704 g, t dbSNP:774261262
1706 1706 a, c dbSNP:1047074
1710 1710 c, t dbSNP:1129316
1712 1712 c, g dbSNP:1129314
1714 1714 c, g dbSNP:377431543
1715 1715 a, g, t dbSNP:1129313
1718 1718 a, c, t dbSNP:1129312
1730 1730 a, g dbSNP:775849795
1735 1735 c, t dbSNP:757846343
1736 1736 a, g dbSNP:151250769
1745 1745 a, g dbSNP:762873779
1746 1746 a, g dbSNP:762423026
1747 1747 a, g dbSNP:752220358
1749 1749 a, g dbSNP:775136828
1753 1753 a, t dbSNP:143645832
1760 1760 a, g dbSNP:759215543
1765 1765 c, g dbSNP:121913477
1770 1770 a, g dbSNP:776413718
1774 1774 a, g dbSNP:121913478
1781 1781 a, g dbSNP:770670545
1787 1787 c, t dbSNP:760627156
1791 1791 g, t dbSNP:387906678
1794 1794 c, t dbSNP:121913474
1798 1798 c, t dbSNP:773178450
1802 1802 a, g dbSNP:772014466
1805 1805 c, g dbSNP:531426519
1806 1806 g, t dbSNP:780167791
1812 1812 a, g dbSNP:769919776
1815 1815 a, g, t dbSNP:781714766
1817 1817 c, g dbSNP:757648006
1821 1821 a, g dbSNP:751951199
1822 1822 g, t dbSNP:387906677
1826 1826 a, g dbSNP:778187292
1841 1841 a, g dbSNP:377132080
1849 1849 a, t dbSNP:752209605
1855 1855 a, g dbSNP:764748528
1858 1858 a, c, t dbSNP:753437208
1862 1862 c, g, t dbSNP:562297920
1863 1863 a, g dbSNP:772986332
1871 1871 a, g dbSNP:771960546
1888 1888 c, t dbSNP:372348666
1889 1889 a, g dbSNP:147674677
1890 1890 a, g dbSNP:769880096
1892 1892 c, t dbSNP:746116691
1895 1895 a, g dbSNP:529337365
1901 1901 -, gctgaccaa dbSNP:781717945
1904 1904 a, g dbSNP:771248107
1916 1916 c, t dbSNP:747449724
1927 1927 a, g dbSNP:769536077
1943 1943 a, g dbSNP:748855113
1952 1952 c, t dbSNP:141297318
1953 1953 a, g dbSNP:146589618
1975 1975 a, c dbSNP:368002690
1976 1976 c, t dbSNP:184889995
1977 1977 c, g dbSNP:7078073
1978 1978 c, t dbSNP:757125418
1979 1979 a, g, t dbSNP:374423103
1980 1980 c, t dbSNP:143361368
1983 1983 a, g dbSNP:776868501
1994 1994 a, g dbSNP:766502777
1995 1995 a, g dbSNP:761012674
1998 1998 c, t dbSNP:536181987
1999 1999 a, g, t dbSNP:773245022
2011 2011 c, t dbSNP:148672240
2012 2012 a, g dbSNP:200183009
2025 2025 a, g, t dbSNP:370602437
2028 2028 c, t dbSNP:755574715
2031 2031 g, t dbSNP:745349225
2032 2032 c, t dbSNP:376451171
2034 2034 c, g dbSNP:756855939
2038 2038 a, t dbSNP:751433223
2073 2073 a, g dbSNP:777657579
2074 2074 a, g dbSNP:758417193
2079 2079 c, g dbSNP:752644307
2080 2080 c, t dbSNP:765241522
2085 2085 c, g dbSNP:760845434
2091 2091 c, t dbSNP:144116729
2098 2098 c, t dbSNP:767430380
2103 2103 a, c dbSNP:774235257
2105 2105 a, c, g dbSNP:149962204
2136 2136 a, g dbSNP:751731391
2144 2144 a, g dbSNP:764280287
2160 2160 a, g dbSNP:370273049
2175 2175 a, g dbSNP:775829173
2176 2176 a, g dbSNP:770391340
2180 2180 g, t dbSNP:759906958
2181 2181 a, g dbSNP:765066758
2182 2182 c, t dbSNP:770309121
2183 2183 a, g dbSNP:138985383
2186 2186 c, t dbSNP:777606451
2189 2189 c, t dbSNP:74160617
2195 2195 c, g, t dbSNP:778789088
2198 2198 a, g dbSNP:200522893
2207 2207 a, g dbSNP:749140651
2212 2212 a, g, t dbSNP:55689343
2215 2215 a, t dbSNP:756076618
2222 2222 a, g dbSNP:74160613
2226 2226 a, g dbSNP:121918507
2237 2237 c, t dbSNP:777772933
2260 2260 a, t dbSNP:758628019
2274 2274 a, g dbSNP:752880857
2287 2287 a, c dbSNP:765658636
2296 2296 a, g dbSNP:763017169
2297 2297 a, t dbSNP:121913476
2299 2299 c, t dbSNP:755350933
2323 2323 a, g dbSNP:761446954
2328 2328 c, t dbSNP:751077552
2336 2336 c, g dbSNP:763714394
2344 2344 a, c dbSNP:121918506
2364 2364 c, t dbSNP:371854567
2396 2396 c, t dbSNP:369850306
2397 2397 a, g dbSNP:138712692
2400 2400 a, g dbSNP:759496676
2411 2411 c, t dbSNP:147173572
2413 2413 a, c dbSNP:770827652
2417 2417 c, t dbSNP:748232060
2424 2424 c, t dbSNP:141929882
2425 2425 a, g dbSNP:768761510
2435 2435 a, g dbSNP:55724054
2438 2438 a, g dbSNP:56335660
2450 2450 c, t dbSNP:375961106
2452 2452 a, g dbSNP:780587674
2453 2453 a, g dbSNP:756595803
2465 2465 a, g dbSNP:750783841
2468 2468 c, g, t dbSNP:371395564
2490 2490 a, g dbSNP:751047267
2495 2495 a, g dbSNP:763592672
2497 2497 a, g dbSNP:762545440
2502 2502 a, g dbSNP:752349068
2510 2510 a, g dbSNP:143796403
2516 2516 c, t dbSNP:369637667
2517 2517 a, g dbSNP:775697900
2532 2532 a, g dbSNP:121918509
2552 2552 a, g dbSNP:770154701
2561 2561 c, t dbSNP:149008039
2563 2563 a, g dbSNP:777169135
2573 2573 a, g dbSNP:771278654
2580 2580 a, g dbSNP:138631412
2585 2585 c, t dbSNP:747316497
2591 2591 c, t dbSNP:35337478
2592 2592 a, g dbSNP:121918508
2599 2599 a, g dbSNP:758829154
2610 2610 a, g dbSNP:747718232
2639 2639 g, t dbSNP:768200252
2640 2640 c, t dbSNP:113014479
2642 2642 a, g dbSNP:748763422
2651 2651 c, g dbSNP:61731218
2666 2666 a, t dbSNP:755708679
2678 2678 c, t dbSNP:766703071
2684 2684 a, g dbSNP:750244862
2685 2685 a, g dbSNP:371596204
2687 2687 a, g dbSNP:141253851
2690 2690 c, t dbSNP:751495618
2701 2701 c, g dbSNP:764102895
2706 2706 a, g dbSNP:760895785
2714 2714 c, t dbSNP:767692675
2717 2717 c, t dbSNP:369130429
2727 2727 a, g dbSNP:774682374
2728 2728 c, t dbSNP:146571201
2755 2755 c, t dbSNP:150015885
2765 2765 a, g dbSNP:763301309
2768 2768 a, g dbSNP:775097622
2774 2774 c, t dbSNP:140813163
2804 2804 a, g dbSNP:777780454
2826 2826 a, g dbSNP:776188535
2839 2839 a, g dbSNP:200453002
2840 2840 c, t dbSNP:55637244
2879 2879 c, g dbSNP:771807547
2880 2880 c, t dbSNP:747941020
2881 2881 c, t dbSNP:375719482
2882 2882 c, t dbSNP:142639988
2888 2888 c, g dbSNP:116895810
2895 2895 a, g dbSNP:754928713
2896 2896 c, t dbSNP:745947630
2900 2900 c, t dbSNP:781182356
2901 2901 a, c dbSNP:757501816
2910 2910 a, g dbSNP:751731823
2911 2911 g, t dbSNP:777950855
2926 2926 a, g dbSNP:55774317
2933 2933 c, t dbSNP:753103160
2939 2939 c, t dbSNP:41294229
2947 2947 a, g dbSNP:765724372
2952 2952 a, g dbSNP:763622845
2958 2958 c, g, t dbSNP:201752803
2961 2961 a, g dbSNP:765174665
2963 2963 c, g dbSNP:759404861
2978 2978 c, g, t dbSNP:148478597
2979 2979 a, c, g dbSNP:374993905
2987 2987 c, t dbSNP:768983108
2996 2996 g, t dbSNP:147439731
3019 3019 a, g dbSNP:780497781
3030 3030 a, g dbSNP:756718577
3049 3049 c, t dbSNP:746336453
3057 3057 a, g dbSNP:781527776
3060 3060 c, g, t dbSNP:575812178
3064 3064 a, c dbSNP:763867175
3065 3065 c, t dbSNP:558460047
3066 3066 a, c, g dbSNP:764959117
3071 3071 a, g dbSNP:371712759
3074 3074 c, g dbSNP:759496942
3076 3076 c, t dbSNP:368003279
3085 3085 a, g dbSNP:766217118
3088 3088 c, g dbSNP:567030847
3094 3094 -, ta dbSNP:771208561
3098 3098 c, t dbSNP:774232306
3099 3099 a, g dbSNP:144176428
3102 3102 a, g dbSNP:749474548
3107 3107 c, t dbSNP:140318221
3117 3117 a, g dbSNP:547079762
3122 3122 -, act dbSNP:747773151
3141 3141 -, a dbSNP:773909650
3141 3141 a, t dbSNP:764198102
3143 3143 a, t dbSNP:763130972
3144 3144 a, g, t dbSNP:775669188
3150 3150 c, t dbSNP:746532522
3173 3173 a, g dbSNP:533590230
3187 3187 a, c dbSNP:571201278
3227 3227 a, g dbSNP:574474794
3253 3253 c, g dbSNP:777204983
3257 3257 a, g dbSNP:758066441
3266 3266 a, c dbSNP:184026174
3267 3267 -, a dbSNP:768166411
3283 3283 a, g dbSNP:778501615
3289 3289 a, g, t dbSNP:753575189
3291 3291 a, g dbSNP:562615339
3299 3299 c, g dbSNP:549203570
3300 3300 c, t dbSNP:4647917
3311 3311 g, t dbSNP:560611144
3313 3313 -, a dbSNP:748777325
3357 3357 a, t dbSNP:751685012
3367 3367 c, g dbSNP:764231570
3372 3372 a, g dbSNP:763095219
3374 3374 a, t dbSNP:1047058
3375 3375 c, t dbSNP:1047057
3382 3382 g, t dbSNP:770127980
3385 3385 a, c dbSNP:760012289
3396 3396 c, t dbSNP:776792297
3398 3398 a, g dbSNP:577983786
3403 3403 c, g dbSNP:747422874
3406 3406 c, t dbSNP:3135824
3409 3409 a, g dbSNP:544250610
3410 3410 c, t dbSNP:778261181
3421 3421 c, t dbSNP:747630815
3432 3432 c, t dbSNP:575896506
3437 3437 a, g dbSNP:3135825
3440 3440 a, g dbSNP:150519853
3501 3501 a, g dbSNP:41294349
3503 3503 a, g dbSNP:570497109
3508 3508 -, a dbSNP:35819635
3519 3519 a, g dbSNP:3135826
3535 3535 c, t dbSNP:778678344
3538 3538 a, t dbSNP:553479127
3541 3541 -, atatatt dbSNP:768174116
3541 3541 a, g dbSNP:768164829
3579 3579 a, g dbSNP:373313930
3583 3583 a, c dbSNP:191969195
3585 3585 a, g dbSNP:41294351
3612 3612 -, ctct dbSNP:576432930
3613 3613 c, t dbSNP:3135827
3673 3673 a, g, t dbSNP:569964727
3681 3681 c, g dbSNP:755059517
3695 3695 c, t dbSNP:533524841
3713 3713 a, g dbSNP:748862832
3719 3719 c, t dbSNP:557758000
3720 3720 c, g dbSNP:537398850
3736 3736 a, g dbSNP:751702753
3757 3757 -, taat dbSNP:548465887
3763 3763 a, c, t dbSNP:185913671
3777 3777 -, t dbSNP:533680275
3790 3790 g, t dbSNP:566155088
3846 3846 c, g dbSNP:549293047
3853 3853 c, g dbSNP:3135828
3865 3865 -, g dbSNP:36087207
3868 3868 -, c dbSNP:34055669
3870 3870 a, g dbSNP:763304190
3891 3891 c, t dbSNP:566653185
3922 3922 c, g dbSNP:781654432
3942 3942 c, t dbSNP:546780606
3944 3944 a, g dbSNP:201270816
3990 3990 a, g dbSNP:55723405
3994 3994 -, a dbSNP:35899971
4013 4013 a, g dbSNP:757687970
4031 4031 a, g dbSNP:751837122
4037 4037 a, g dbSNP:185617859
4041 4041 c, t dbSNP:3135829
4042 4042 a, g dbSNP:181383630
4050 4050 a, g dbSNP:776274615
4067 4067 g, t dbSNP:763034342
4076 4076 c, t dbSNP:41294353
4133 4133 c, t dbSNP:752834125
4173 4173 c, t dbSNP:562090437
4242 4242 c, t dbSNP:370106008
4247 4247 a, g dbSNP:764293761
4256 4256 a, g dbSNP:189063367
4329 4329 c, t dbSNP:765345628
4330 4330 a, g dbSNP:573135661
4370 4370 a, g dbSNP:367769355
4387 4387 c, g dbSNP:553168000
4388 4388 c, g dbSNP:545961397
4417 4417 a, c, t dbSNP:71640261
4435 4435 a, g dbSNP:3135830
4480 4480 a, g dbSNP:568759526
4502 4502 a, g dbSNP:555730451
4521 4521 a, g dbSNP:535761567
4523 4523 c, t dbSNP:532417198
4594 4594 a, g dbSNP:566742541
4614 4614 -, ataaa dbSNP:566259479
4628 4628 a, g dbSNP:141765473

Target ORF information:

RefSeq Version NM_022970
Organism Homo sapiens (human)
Definition Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022970

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA GCCACCAACC
AAATACCAAA TCTCTCAACC AGAAGTGTAC GTGGCTGCGC CAGGGGAGTC GCTAGAGGTG
CGCTGCCTGT TGAAAGATGC CGCCGTGATC AGTTGGACTA AGGATGGGGT GCACTTGGGG
CCCAACAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAGGGCGC CACGCCTAGA
GACTCCGGCC TCTATGCTTG TACTGCCAGT AGGACTGTAG ACAGTGAAAC TTGGTACTTC
ATGGTGAATG TCACAGATGC CATCTCATCC GGAGATGATG AGGATGACAC CGATGGTGCG
GAAGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA
AAGATGGAAA AGCGGCTCCA TGCTGTGCCT GCGGCCAACA CTGTCAAGTT TCGCTGCCCA
GCCGGGGGGA ACCCAATGCC AACCATGCGG TGGCTGAAAA ACGGGAAGGA GTTTAAGCAG
GAGCATCGCA TTGGAGGCTA CAAGGTACGA AACCAGCACT GGAGCCTCAT TATGGAAAGT
GTGGTCCCAT CTGACAAGGG AAATTATACC TGTGTAGTGG AGAATGAATA CGGGTCCATC
AATCACACGT ACCACCTGGA TGTTGTGGAG CGATCGCCTC ACCGGCCCAT CCTCCAAGCC
GGACTGCCGG CAAATGCCTC CACAGTGGTC GGAGGAGACG TAGAGTTTGT CTGCAAGGTT
TACAGTGATG CCCAGCCCCA CATCCAGTGG ATCAAGCACG TGGAAAAGAA CGGCAGTAAA
TACGGGCCCG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC
AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACCGAGGCGG ATGCTGGGGA ATATATATGT
AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCAAAA
CAGCAAGCGC CTGGAAGAGA AAAGGAGATT ACAGCTTCCC CAGACTACCT GGAGATAGCC
ATTTACTGCA TAGGGGTCTT CTTAATCGCC TGTATGGTGG TAACAGTCAT CCTGTGCCGA
ATGAAGAACA CGACCAAGAA GCCAGACTTC AGCAGCCAGC CGGCTGTGCA CAAGCTGACC
AAACGTATCC CCCTGCGGAG ACAGGTAACA GTTTCGGCTG AGTCCAGCTC CTCCATGAAC
TCCAACACCC CGCTGGTGAG GATAACAACA CGCCTCTCTT CAACGGCAGA CACCCCCATG
CTGGCAGGGG TCTCCGAGTA TGAACTTCCA GAGGACCCAA AATGGGAGTT TCCAAGAGAT
AAGCTGACAC TGGGCAAGCC CCTGGGAGAA GGTTGCTTTG GGCAAGTGGT CATGGCGGAA
GCAGTGGGAA TTGACAAAGA CAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGTTG
AAAGATGATG CCACAGAGAA AGACCTTTCT GATCTGGTGT CAGAGATGGA GATGATGAAG
ATGATTGGGA AACACAAGAA TATCATAAAT CTTCTTGGAG CCTGCACACA GGATGGGCCT
CTCTATGTCA TAGTTGAGTA TGCCTCTAAA GGCAACCTCC GAGAATACCT CCGAGCCCGG
AGGCCACCCG GGATGGAGTA CTCCTATGAC ATTAACCGTG TTCCTGAGGA GCAGATGACC
TTCAAGGACT TGGTGTCATG CACCTACCAG CTGGCCAGAG GCATGGAGTA CTTGGCTTCC
CAAAAATGTA TTCATCGAGA TTTAGCAGCC AGAAATGTTT TGGTAACAGA AAACAATGTG
ATGAAAATAG CAGACTTTGG ACTCGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG
ACCACCAATG GGCGGCTTCC AGTCAAGTGG ATGGCTCCAG AAGCCCTGTT TGATAGAGTA
TACACTCATC AGAGTGATGT CTGGTCCTTC GGGGTGTTAA TGTGGGAGAT CTTCACTTTA
GGGGGCTCGC CCTACCCAGG GATTCCCGTG GAGGAACTTT TTAAGCTGCT GAAGGAAGGA
CACAGAATGG ATAAGCCAGC CAACTGCACC AACGAACTGT ACATGATGAT GAGGGACTGT
TGGCATGCAG TGCCCTCCCA GAGACCAACG TTCAAGCAGT TGGTAGAAGA CTTGGATCGA
ATTCTCACTC TCACAACCAA TGAGGAATAC TTGGACCTCA GCCAACCTCT CGAACAGTAT
TCACCTAGTT ACCCTGACAC AAGAAGTTCT TGTTCTTCAG GAGATGATTC TGTTTTTTCT
CCAGACCCCA TGCCTTACGA ACCATGCCTT CCTCAGTATC CACACATAAA CGGCAGTGTT
AAAACATGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu22945D
Sequence Information ORF Nucleotide Sequence (Length: 2310bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product fibroblast growth factor receptor 2 isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M97193.1, U11814.1, X56191.1, AC009988.12 and AK026508.1. Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. A downstream AUG translation start codon is selected for this RefSeq based on the presence of a strong Kozak consensus signal, a strong community standard for the use of the downstream start codon, and on a higher probability of an N-terminal signal peptide being present in the resulting protein. The use of an alternative in-frame upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. Translation from the annotated downstream start codon is likely to occur via leaky scanning and/or reinitiation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X56191.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID: 15863034) ##RefSeq-Attributes-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA GCCACCAACC
AAATACCAAA TCTCTCAACC AGAAGTGTAC GTGGCTGCGC CAGGGGAGTC GCTAGAGGTG
CGCTGCCTGT TGAAAGATGC CGCCGTGATC AGTTGGACTA AGGATGGGGT GCACTTGGGG
CCCAACAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAGGGCGC CACGCCTAGA
GACTCCGGCC TCTATGCTTG TACTGCCAGT AGGACTGTAG ACAGTGAAAC TTGGTACTTC
ATGGTGAATG TCACAGATGC CATCTCATCC GGAGATGATG AGGATGACAC CGATGGTGCG
GAAGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA
AAGATGGAAA AGCGGCTCCA TGCTGTGCCT GCGGCCAACA CTGTCAAGTT TCGCTGCCCA
GCCGGGGGGA ACCCAATGCC AACCATGCGG TGGCTGAAAA ACGGGAAGGA GTTTAAGCAG
GAGCATCGCA TTGGAGGCTA CAAGGTACGA AACCAGCACT GGAGCCTCAT TATGGAAAGT
GTGGTCCCAT CTGACAAGGG AAATTATACC TGTGTAGTGG AGAATGAATA CGGGTCCATC
AATCACACGT ACCACCTGGA TGTTGTGGAG CGATCGCCTC ACCGGCCCAT CCTCCAAGCC
GGACTGCCGG CAAATGCCTC CACAGTGGTC GGAGGAGACG TAGAGTTTGT CTGCAAGGTT
TACAGTGATG CCCAGCCCCA CATCCAGTGG ATCAAGCACG TGGAAAAGAA CGGCAGTAAA
TACGGGCCCG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC
AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACCGAGGCGG ATGCTGGGGA ATATATATGT
AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCAAAA
CAGCAAGCGC CTGGAAGAGA AAAGGAGATT ACAGCTTCCC CAGACTACCT GGAGATAGCC
ATTTACTGCA TAGGGGTCTT CTTAATCGCC TGTATGGTGG TAACAGTCAT CCTGTGCCGA
ATGAAGAACA CGACCAAGAA GCCAGACTTC AGCAGCCAGC CGGCTGTGCA CAAGCTGACC
AAACGTATCC CCCTGCGGAG ACAGGTAACA GTTTCGGCTG AGTCCAGCTC CTCCATGAAC
TCCAACACCC CGCTGGTGAG GATAACAACA CGCCTCTCTT CAACGGCAGA CACCCCCATG
CTGGCAGGGG TCTCCGAGTA TGAACTTCCA GAGGACCCAA AATGGGAGTT TCCAAGAGAT
AAGCTGACAC TGGGCAAGCC CCTGGGAGAA GGTTGCTTTG GGCAAGTGGT CATGGCGGAA
GCAGTGGGAA TTGACAAAGA CAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGTTG
AAAGATGATG CCACAGAGAA AGACCTTTCT GATCTGGTGT CAGAGATGGA GATGATGAAG
ATGATTGGGA AACACAAGAA TATCATAAAT CTTCTTGGAG CCTGCACACA GGATGGGCCT
CTCTATGTCA TAGTTGAGTA TGCCTCTAAA GGCAACCTCC GAGAATACCT CCGAGCCCGG
AGGCCACCCG GGATGGAGTA CTCCTATGAC ATTAACCGTG TTCCTGAGGA GCAGATGACC
TTCAAGGACT TGGTGTCATG CACCTACCAG CTGGCCAGAG GCATGGAGTA CTTGGCTTCC
CAAAAATGTA TTCATCGAGA TTTAGCAGCC AGAAATGTTT TGGTAACAGA AAACAATGTG
ATGAAAATAG CAGACTTTGG ACTCGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG
ACCACCAATG GGCGGCTTCC AGTCAAGTGG ATGGCTCCAG AAGCCCTGTT TGATAGAGTA
TACACTCATC AGAGTGATGT CTGGTCCTTC GGGGTGTTAA TGTGGGAGAT CTTCACTTTA
GGGGGCTCGC CCTACCCAGG GATTCCCGTG GAGGAACTTT TTAAGCTGCT GAAGGAAGGA
CACAGAATGG ATAAGCCAGC CAACTGCACC AACGAACTGT ACATGATGAT GAGGGACTGT
TGGCATGCAG TGCCCTCCCA GAGACCAACG TTCAAGCAGT TGGTAGAAGA CTTGGATCGA
ATTCTCACTC TCACAACCAA TGAGATCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001138385.1
CDS151..2460
Misc Feature(1)34..36(+)
Misc Feature(2)94..97(+)
Misc Feature(3)289..522(+)
Misc Feature(4)310..480(+)
Misc Feature(5)640..894(+)
Misc Feature(6)646..660(+)
Misc Feature(7)649..684(+)
Misc Feature(8)667..864(+)
Misc Feature(9)937..1221(+)
Misc Feature(10)961..1224(+)
Misc Feature(11)988..1182(+)
Misc Feature(12)1519..2454(+)
Misc Feature(13)1594..2424(+)
Misc Feature(14)1612..2280(+)
Misc Feature(15)1612..2085(+)
Misc Feature(16)2029..2280(+)
Misc Feature(17)2080..2157(+)
Exon (1)1..259
Gene:FGFR2
Gene Synonym:
Exon (2)260..526
Gene:FGFR2
Gene Synonym:
Exon (3)527..604
Gene:FGFR2
Gene Synonym:
Exon (4)605..774
Gene:FGFR2
Gene Synonym:
Exon (5)775..898
Gene:FGFR2
Gene Synonym:
Exon (6)899..1089
Gene:FGFR2
Gene Synonym:
Exon (7)1090..1237
Gene:FGFR2
Gene Synonym:
Exon (8)1238..1440
Gene:FGFR2
Gene Synonym:
Exon (9)1441..1592
Gene:FGFR2
Gene Synonym:
Exon (10)1593..1714
Gene:FGFR2
Gene Synonym:
Exon (11)1715..1825
Gene:FGFR2
Gene Synonym:
Exon (12)1826..2016
Gene:FGFR2
Gene Synonym:
Exon (13)2017..2139
Gene:FGFR2
Gene Synonym:
Exon (14)2140..2210
Gene:FGFR2
Gene Synonym:
Exon (15)2211..2348
Gene:FGFR2
Gene Synonym:
Exon (16)2349..2454
Gene:FGFR2
Gene Synonym:
Exon (17)2455..2781
Gene:FGFR2
Gene Synonym:
Translation
Position Chain Variation Link
4 4 c, t dbSNP:769814958
12 12 a, g dbSNP:574834089
16 16 c, t dbSNP:554557891
23 23 a, g dbSNP:547739869
43 43 c, t dbSNP:540720034
44 44 g, t dbSNP:761776466
55 55 g, t dbSNP:775497340
60 60 g, t dbSNP:769902826
61 61 c, t dbSNP:759690410
62 62 a, c, g dbSNP:771307977
64 64 a, g dbSNP:747423954
69 69 c, t dbSNP:778082131
73 73 g, t dbSNP:772523670
75 75 c, t dbSNP:748677100
76 76 c, t dbSNP:41287990
77 77 a, g dbSNP:4647922
79 79 -, agaggaagt dbSNP:780553051
80 80 a, g dbSNP:748929124
85 85 a, g dbSNP:779800206
89 89 -, t dbSNP:770287475
90 90 g, t dbSNP:3135721
104 104 c, t dbSNP:755803072
105 105 a, g dbSNP:201606812
110 110 a, c dbSNP:767413285
114 114 c, g dbSNP:757197396
120 120 c, t dbSNP:751455486
127 127 a, g dbSNP:765236201
131 131 c, t dbSNP:759620495
132 132 a, g dbSNP:776670842
134 134 c, g dbSNP:766629665
139 139 g, t dbSNP:760884709
144 144 c, t dbSNP:773626594
145 145 a, g dbSNP:772427122
148 148 a, c dbSNP:748610621
151 151 a, g dbSNP:774885289
165 165 c, t dbSNP:768068971
166 166 c, t dbSNP:141724446
167 167 a, c, g dbSNP:3750819
173 173 g, t dbSNP:147307031
174 174 c, t dbSNP:781146007
178 178 c, g dbSNP:370122049
183 183 c, g, t dbSNP:200562301
184 184 a, g dbSNP:143978938
191 191 c, t dbSNP:753987054
200 200 c, t dbSNP:766435280
206 206 c, t dbSNP:760903123
212 212 c, t dbSNP:773358865
214 214 c, t dbSNP:377570596
215 215 a, g dbSNP:189010277
218 218 a, c dbSNP:774554190
219 219 c, t dbSNP:769243397
237 237 a, g dbSNP:749806452
244 244 a, g dbSNP:775194870
246 246 a, g dbSNP:769369328
250 250 c, g dbSNP:373546701
255 255 a, g dbSNP:780856634
258 258 a, g dbSNP:770654393
262 262 c, t dbSNP:775973432
264 264 a, g dbSNP:370046872
269 269 c, t dbSNP:746629822
277 277 a, c dbSNP:777638930
279 279 a, c dbSNP:771790476
288 288 a, c dbSNP:748117555
291 291 a, g dbSNP:778777292
293 293 a, c dbSNP:200700308
300 300 c, t dbSNP:376622125
308 308 c, t dbSNP:371358242
309 309 a, g, t dbSNP:1047102
310 310 c, t dbSNP:151126801
320 320 c, t dbSNP:56226109
321 321 a, g dbSNP:753279848
332 332 a, g dbSNP:199575491
343 343 a, g dbSNP:760115258
346 346 a, g dbSNP:148514974
350 350 c, t dbSNP:145746586
351 351 c, t dbSNP:200386134
352 352 a, g dbSNP:374996878
353 353 c, t dbSNP:537841180
354 354 c, g dbSNP:747982371
355 355 a, g dbSNP:371714070
358 358 a, g dbSNP:768650541
372 372 a, g dbSNP:367962518
378 378 a, g dbSNP:781348632
379 379 a, g dbSNP:757219761
381 381 a, g dbSNP:747287641
384 384 c, t dbSNP:778093907
385 385 c, t dbSNP:758671612
392 392 c, t dbSNP:753179677
397 397 a, g dbSNP:765682593
398 398 a, g dbSNP:748315048
399 399 c, t dbSNP:755520875
401 401 g, t dbSNP:144714823
402 402 a, g dbSNP:779848635
413 413 c, t dbSNP:200369248
429 429 a, g dbSNP:760052114
438 438 c, t dbSNP:55806379
439 439 a, g dbSNP:372430349
444 444 a, g dbSNP:1047101
449 449 a, g dbSNP:774193926
456 456 c, t dbSNP:368662264
459 459 c, t dbSNP:749255726
460 460 c, t dbSNP:775253363
486 486 c, t dbSNP:771065999
503 503 a, g, t dbSNP:139263005
510 510 a, c dbSNP:758751243
512 512 c, t dbSNP:748322657
514 514 a, g dbSNP:779423644
518 518 a, g dbSNP:375935265
525 525 a, t dbSNP:754388941
537 537 a, t dbSNP:749651751
541 541 a, g dbSNP:780458049
543 543 a, g dbSNP:756641429
548 548 a, t dbSNP:750876096
549 549 c, g, t dbSNP:373155033
551 551 a, t dbSNP:751236652
561 561 c, t dbSNP:763704465
568 568 a, g dbSNP:762636391
569 569 c, t dbSNP:752501698
570 570 a, g dbSNP:765024365
571 571 a, g dbSNP:759550441
587 587 a, g dbSNP:776668623
592 592 a, g dbSNP:772298926
599 599 a, g dbSNP:762030875
600 600 -, caa dbSNP:752218106
603 603 c, g dbSNP:774538633
606 606 a, g dbSNP:763094016
607 607 a, g dbSNP:775743948
619 619 a, g dbSNP:770169545
623 623 a, g dbSNP:112880592
627 627 a, g dbSNP:746281842
644 644 a, g dbSNP:146244307
648 648 c, t dbSNP:777075226
651 651 c, t dbSNP:766869457
663 663 a, g dbSNP:747502119
683 683 a, g dbSNP:141796960
687 687 c, t dbSNP:139617492
693 693 c, t dbSNP:150598483
694 694 a, g, t dbSNP:200766273
699 699 g, t dbSNP:753750519
701 701 a, t dbSNP:202212545
702 702 a, c, g dbSNP:750312209
706 706 a, g dbSNP:55977237
707 707 c, t dbSNP:755793
711 711 a, g dbSNP:775411475
716 716 c, t dbSNP:761753706
718 718 c, t dbSNP:147987917
719 719 a, g dbSNP:759750319
725 725 a, t dbSNP:777039355
732 732 c, t dbSNP:771218136
758 758 a, g dbSNP:747502397
766 766 a, g dbSNP:773718005
816 816 a, c dbSNP:755490768
825 825 c, g dbSNP:537758598
833 833 a, t dbSNP:146948953
836 836 a, t dbSNP:368224180
846 846 a, g, t dbSNP:1047100
849 849 a, g dbSNP:748983200
850 850 c, g dbSNP:779806520
861 861 c, t dbSNP:769311722
865 865 a, t dbSNP:555207905
866 866 c, t dbSNP:780846065
868 868 a, g dbSNP:757276690
870 870 c, g dbSNP:751395138
877 877 a, g dbSNP:778994181
878 878 c, t dbSNP:755001161
879 879 a, g dbSNP:199890227
900 900 a, g dbSNP:771784064
901 901 a, c dbSNP:748113099
905 905 cgc, tct dbSNP:281865420
905 905 cg, tt dbSNP:121918498
905 905 c, g, t dbSNP:79184941
906 906 ctt, gcc dbSNP:387907372
906 906 a, g dbSNP:138769323
908 908 c, g dbSNP:77543610
909 909 g, t dbSNP:3135755
913 913 c, t dbSNP:149200230
915 915 c, g dbSNP:200759234
922 922 c, t dbSNP:747171741
930 930 c, t dbSNP:778288494
936 936 a, g, t dbSNP:753082618
938 938 c, t dbSNP:779326224
939 939 a, g dbSNP:138315382
949 949 c, t dbSNP:121918505
951 951 c, t dbSNP:753345992
954 954 a, g dbSNP:765814642
960 960 a, c, t dbSNP:150488750
961 961 a, g dbSNP:183250272
963 963 a, g dbSNP:761649011
967 967 -, gac dbSNP:121918503
969 969 c, g, t dbSNP:140427785
980 980 c, t dbSNP:762937564
983 983 g, t dbSNP:776587763
987 987 a, g dbSNP:771068222
1002 1002 c, g dbSNP:747267954
1006 1006 c, t dbSNP:778094013
1008 1008 a, c dbSNP:772391649
1016 1016 a, c dbSNP:121918497
1018 1018 c, g, t dbSNP:121918501
1020 1020 c, g, t dbSNP:121918499
1024 1024 a, g dbSNP:121918500
1027 1027 c, t dbSNP:748526473
1029 1029 c, t dbSNP:55745510
1030 1030 a, g dbSNP:755453106
1041 1041 c, t dbSNP:754300987
1042 1042 a, g dbSNP:779566502
1049 1049 a, g dbSNP:755570604
1053 1053 c, t dbSNP:768862267
1056 1056 g, t dbSNP:532964975
1058 1058 c, g dbSNP:374608214
1059 1059 c, t dbSNP:761525014
1060 1060 a, g dbSNP:370877537
1062 1062 c, t dbSNP:570589620
1066 1066 c, g dbSNP:199937788
1068 1068 a, g dbSNP:762804005
1074 1074 c, t dbSNP:775459922
1075 1075 c, t dbSNP:4647921
1079 1079 a, g dbSNP:121913475
1081 1081 a, g dbSNP:771158421
1091 1091 a, g dbSNP:3206759
1095 1095 a, g dbSNP:749699527
1097 1097 g, t dbSNP:1129324
1098 1098 a, g dbSNP:775831408
1099 1099 a, g, t dbSNP:1143401
1106 1106 a, g dbSNP:770347175
1112 1112 a, c dbSNP:1129323
1113 1113 g, t dbSNP:1129322
1119 1119 a, g dbSNP:369682344
1121 1121 a, t dbSNP:1129321
1122 1122 a, g, t dbSNP:756750786
1123 1123 a, c dbSNP:1129320
1129 1129 c, g dbSNP:563769835
1131 1131 a, g dbSNP:1143402
1136 1136 a, g dbSNP:777532382
1140 1140 a, g dbSNP:1129318
1143 1143 c, t dbSNP:752595302
1148 1148 a, c, t dbSNP:1047095
1149 1149 a, g dbSNP:768008676
1152 1152 c, t dbSNP:1047090
1161 1161 a, g dbSNP:753784222
1166 1166 c, t dbSNP:1047088
1167 1167 a, g dbSNP:1047087
1175 1175 g, t dbSNP:1065581
1184 1184 a, c dbSNP:1047083
1185 1185 c, t dbSNP:187206427
1188 1188 a, t dbSNP:1047082
1192 1192 a, c dbSNP:1065582
1194 1194 g, t dbSNP:1047078
1199 1199 a, t dbSNP:1047077
1203 1203 c, g dbSNP:1047076
1207 1207 g, t dbSNP:774261262
1209 1209 a, c dbSNP:1047074
1213 1213 c, t dbSNP:1129316
1215 1215 c, g dbSNP:1129314
1217 1217 c, g dbSNP:377431543
1218 1218 a, g, t dbSNP:1129313
1221 1221 a, c, t dbSNP:1129312
1233 1233 a, g dbSNP:775849795
1238 1238 c, t dbSNP:757846343
1239 1239 a, g dbSNP:151250769
1248 1248 a, g dbSNP:762873779
1249 1249 a, g dbSNP:762423026
1250 1250 a, g dbSNP:752220358
1252 1252 a, g dbSNP:775136828
1256 1256 a, t dbSNP:143645832
1263 1263 a, g dbSNP:759215543
1268 1268 c, g dbSNP:121913477
1273 1273 a, g dbSNP:776413718
1277 1277 a, g dbSNP:121913478
1284 1284 a, g dbSNP:770670545
1290 1290 c, t dbSNP:760627156
1294 1294 g, t dbSNP:387906678
1297 1297 c, t dbSNP:121913474
1301 1301 c, t dbSNP:773178450
1305 1305 a, g dbSNP:772014466
1308 1308 c, g dbSNP:531426519
1309 1309 g, t dbSNP:780167791
1315 1315 a, g dbSNP:769919776
1318 1318 a, g, t dbSNP:781714766
1320 1320 c, g dbSNP:757648006
1324 1324 a, g dbSNP:751951199
1325 1325 g, t dbSNP:387906677
1329 1329 a, g dbSNP:778187292
1344 1344 a, g dbSNP:377132080
1352 1352 a, t dbSNP:752209605
1358 1358 a, g dbSNP:764748528
1361 1361 a, c, t dbSNP:753437208
1365 1365 c, g, t dbSNP:562297920
1366 1366 a, g dbSNP:772986332
1374 1374 a, g dbSNP:771960546
1391 1391 c, t dbSNP:372348666
1392 1392 a, g dbSNP:147674677
1393 1393 a, g dbSNP:769880096
1395 1395 c, t dbSNP:746116691
1398 1398 a, g dbSNP:529337365
1404 1404 -, gctgaccaa dbSNP:781717945
1407 1407 a, g dbSNP:771248107
1419 1419 c, t dbSNP:747449724
1430 1430 a, g dbSNP:769536077
1446 1446 a, g dbSNP:748855113
1455 1455 c, t dbSNP:141297318
1456 1456 a, g dbSNP:146589618
1478 1478 a, c dbSNP:368002690
1479 1479 c, t dbSNP:184889995
1480 1480 c, g dbSNP:7078073
1481 1481 c, t dbSNP:757125418
1482 1482 a, g, t dbSNP:374423103
1483 1483 c, t dbSNP:143361368
1486 1486 a, g dbSNP:776868501
1497 1497 a, g dbSNP:766502777
1498 1498 a, g dbSNP:761012674
1501 1501 c, t dbSNP:536181987
1502 1502 a, g, t dbSNP:773245022
1514 1514 c, t dbSNP:148672240
1515 1515 a, g dbSNP:200183009
1528 1528 a, g, t dbSNP:370602437
1531 1531 c, t dbSNP:755574715
1534 1534 g, t dbSNP:745349225
1535 1535 c, t dbSNP:376451171
1537 1537 c, g dbSNP:756855939
1541 1541 a, t dbSNP:751433223
1576 1576 a, g dbSNP:777657579
1577 1577 a, g dbSNP:758417193
1582 1582 c, g dbSNP:752644307
1583 1583 c, t dbSNP:765241522
1588 1588 c, g dbSNP:760845434
1594 1594 c, t dbSNP:144116729
1601 1601 c, t dbSNP:767430380
1606 1606 a, c dbSNP:774235257
1608 1608 a, c, g dbSNP:149962204
1639 1639 a, g dbSNP:751731391
1647 1647 a, g dbSNP:764280287
1663 1663 a, g dbSNP:370273049
1678 1678 a, g dbSNP:775829173
1679 1679 a, g dbSNP:770391340
1683 1683 g, t dbSNP:759906958
1684 1684 a, g dbSNP:765066758
1685 1685 c, t dbSNP:770309121
1686 1686 a, g dbSNP:138985383
1689 1689 c, t dbSNP:777606451
1692 1692 c, t dbSNP:74160617
1698 1698 c, g, t dbSNP:778789088
1701 1701 a, g dbSNP:200522893
1710 1710 a, g dbSNP:749140651
1715 1715 a, g, t dbSNP:55689343
1718 1718 a, t dbSNP:756076618
1725 1725 a, g dbSNP:74160613
1729 1729 a, g dbSNP:121918507
1740 1740 c, t dbSNP:777772933
1763 1763 a, t dbSNP:758628019
1777 1777 a, g dbSNP:752880857
1790 1790 a, c dbSNP:765658636
1799 1799 a, g dbSNP:763017169
1800 1800 a, t dbSNP:121913476
1802 1802 c, t dbSNP:755350933
1826 1826 a, g dbSNP:761446954
1831 1831 c, t dbSNP:751077552
1839 1839 c, g dbSNP:763714394
1847 1847 a, c dbSNP:121918506
1867 1867 c, t dbSNP:371854567
1899 1899 c, t dbSNP:369850306
1900 1900 a, g dbSNP:138712692
1903 1903 a, g dbSNP:759496676
1914 1914 c, t dbSNP:147173572
1916 1916 a, c dbSNP:770827652
1920 1920 c, t dbSNP:748232060
1927 1927 c, t dbSNP:141929882
1928 1928 a, g dbSNP:768761510
1938 1938 a, g dbSNP:55724054
1941 1941 a, g dbSNP:56335660
1953 1953 c, t dbSNP:375961106
1955 1955 a, g dbSNP:780587674
1956 1956 a, g dbSNP:756595803
1968 1968 a, g dbSNP:750783841
1971 1971 c, g, t dbSNP:371395564
1993 1993 a, g dbSNP:751047267
1998 1998 a, g dbSNP:763592672
2000 2000 a, g dbSNP:762545440
2005 2005 a, g dbSNP:752349068
2013 2013 a, g dbSNP:143796403
2019 2019 c, t dbSNP:369637667
2020 2020 a, g dbSNP:775697900
2035 2035 a, g dbSNP:121918509
2055 2055 a, g dbSNP:770154701
2064 2064 c, t dbSNP:149008039
2066 2066 a, g dbSNP:777169135
2076 2076 a, g dbSNP:771278654
2083 2083 a, g dbSNP:138631412
2088 2088 c, t dbSNP:747316497
2094 2094 c, t dbSNP:35337478
2095 2095 a, g dbSNP:121918508
2102 2102 a, g dbSNP:758829154
2113 2113 a, g dbSNP:747718232
2142 2142 g, t dbSNP:768200252
2143 2143 c, t dbSNP:113014479
2145 2145 a, g dbSNP:748763422
2154 2154 c, g dbSNP:61731218
2169 2169 a, t dbSNP:755708679
2181 2181 c, t dbSNP:766703071
2187 2187 a, g dbSNP:750244862
2188 2188 a, g dbSNP:371596204
2190 2190 a, g dbSNP:141253851
2193 2193 c, t dbSNP:751495618
2204 2204 c, g dbSNP:764102895
2209 2209 a, g dbSNP:760895785
2217 2217 c, t dbSNP:767692675
2220 2220 c, t dbSNP:369130429
2230 2230 a, g dbSNP:774682374
2231 2231 c, t dbSNP:146571201
2258 2258 c, t dbSNP:150015885
2268 2268 a, g dbSNP:763301309
2271 2271 a, g dbSNP:775097622
2277 2277 c, t dbSNP:140813163
2307 2307 a, g dbSNP:777780454
2329 2329 a, g dbSNP:776188535
2342 2342 a, g dbSNP:200453002
2343 2343 c, t dbSNP:55637244
2382 2382 c, g dbSNP:771807547
2383 2383 c, t dbSNP:747941020
2384 2384 c, t dbSNP:375719482
2385 2385 c, t dbSNP:142639988
2391 2391 c, g dbSNP:116895810
2398 2398 a, g dbSNP:754928713
2399 2399 c, t dbSNP:745947630
2403 2403 c, t dbSNP:781182356
2404 2404 a, c dbSNP:757501816
2413 2413 a, g dbSNP:751731823
2414 2414 g, t dbSNP:777950855
2429 2429 a, g dbSNP:55774317
2436 2436 c, t dbSNP:753103160
2442 2442 c, t dbSNP:41294229
2450 2450 a, g dbSNP:765724372
2457 2457 c, t dbSNP:141859447
2458 2458 c, t dbSNP:760325538
2460 2460 a, g dbSNP:189179463
2462 2462 a, g dbSNP:767087309
2475 2475 a, c dbSNP:761461334
2476 2476 c, t dbSNP:774044462
2478 2478 a, g dbSNP:375710806
2481 2481 a, t dbSNP:762713784
2486 2486 a, g dbSNP:535400031
2504 2504 a, g dbSNP:775447145
2508 2508 g, t dbSNP:769719941
2509 2509 g, t dbSNP:200278526
2526 2526 c, t dbSNP:536927124
2528 2528 a, g dbSNP:574612332
2529 2529 c, g dbSNP:147554123
2530 2530 c, t dbSNP:3135816
2531 2531 a, t dbSNP:534483929
2549 2549 a, c dbSNP:139084360
2552 2552 c, t dbSNP:565843853
2556 2556 a, t dbSNP:552241447
2580 2580 a, c dbSNP:150752549
2592 2592 a, g dbSNP:776876500
2609 2609 c, t dbSNP:142164196
2615 2615 a, g dbSNP:538690729
2619 2619 c, t dbSNP:546713812
2631 2631 c, g dbSNP:148674731
2634 2634 a, g dbSNP:544441963
2650 2650 a, g dbSNP:1649167
2658 2658 -, c dbSNP:34746266
2677 2677 c, g dbSNP:142639466
2690 2690 a, g dbSNP:561597310
2701 2701 c, t dbSNP:773483369
2702 2702 a, g dbSNP:548012317
2727 2727 a, g dbSNP:185651231
2743 2743 a, g dbSNP:576719973
2753 2753 g, t dbSNP:138142308
2756 2756 c, g dbSNP:146298298
2757 2757 a, g dbSNP:57571942
2763 2763 a, g dbSNP:1649166
2773 2773 a, g dbSNP:3135817
2775 2775 c, t dbSNP:150230459

Target ORF information:

RefSeq Version NM_001144913
Organism Homo sapiens (human)
Definition Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001144913

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA GCCACCAACC
AAATACCAAA TCTCTCAACC AGAAGTGTAC GTGGCTGCGC CAGGGGAGTC GCTAGAGGTG
CGCTGCCTGT TGAAAGATGC CGCCGTGATC AGTTGGACTA AGGATGGGGT GCACTTGGGG
CCCAACAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAGGGCGC CACGCCTAGA
GACTCCGGCC TCTATGCTTG TACTGCCAGT AGGACTGTAG ACAGTGAAAC TTGGTACTTC
ATGGTGAATG TCACAGATGC CATCTCATCC GGAGATGATG AGGATGACAC CGATGGTGCG
GAAGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA
AAGATGGAAA AGCGGCTCCA TGCTGTGCCT GCGGCCAACA CTGTCAAGTT TCGCTGCCCA
GCCGGGGGGA ACCCAATGCC AACCATGCGG TGGCTGAAAA ACGGGAAGGA GTTTAAGCAG
GAGCATCGCA TTGGAGGCTA CAAGGTACGA AACCAGCACT GGAGCCTCAT TATGGAAAGT
GTGGTCCCAT CTGACAAGGG AAATTATACC TGTGTAGTGG AGAATGAATA CGGGTCCATC
AATCACACGT ACCACCTGGA TGTTGTGGAG CGATCGCCTC ACCGGCCCAT CCTCCAAGCC
GGACTGCCGG CAAATGCCTC CACAGTGGTC GGAGGAGACG TAGAGTTTGT CTGCAAGGTT
TACAGTGATG CCCAGCCCCA CATCCAGTGG ATCAAGCACG TGGAAAAGAA CGGCAGTAAA
TACGGGCCCG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC
AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACCGAGGCGG ATGCTGGGGA ATATATATGT
AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCAAAA
CAGCAAGCGC CTGGAAGAGA AAAGGAGATT ACAGCTTCCC CAGACTACCT GGAGATAGCC
ATTTACTGCA TAGGGGTCTT CTTAATCGCC TGTATGGTGG TAACAGTCAT CCTGTGCCGA
ATGAAGAACA CGACCAAGAA GCCAGACTTC AGCAGCCAGC CGGCTGTGCA CAAGCTGACC
AAACGTATCC CCCTGCGGAG ACAGGTAACA GTTTCGGCTG AGTCCAGCTC CTCCATGAAC
TCCAACACCC CGCTGGTGAG GATAACAACA CGCCTCTCTT CAACGGCAGA CACCCCCATG
CTGGCAGGGG TCTCCGAGTA TGAACTTCCA GAGGACCCAA AATGGGAGTT TCCAAGAGAT
AAGCTGACAC TGGGCAAGCC CCTGGGAGAA GGTTGCTTTG GGCAAGTGGT CATGGCGGAA
GCAGTGGGAA TTGACAAAGA CAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGTTG
AAAGATGATG CCACAGAGAA AGACCTTTCT GATCTGGTGT CAGAGATGGA GATGATGAAG
ATGATTGGGA AACACAAGAA TATCATAAAT CTTCTTGGAG CCTGCACACA GGATGGGCCT
CTCTATGTCA TAGTTGAGTA TGCCTCTAAA GGCAACCTCC GAGAATACCT CCGAGCCCGG
AGGCCACCCG GGATGGAGTA CTCCTATGAC ATTAACCGTG TTCCTGAGGA GCAGATGACC
TTCAAGGACT TGGTGTCATG CACCTACCAG CTGGCCAGAG GCATGGAGTA CTTGGCTTCC
CAAAAATGTA TTCATCGAGA TTTAGCAGCC AGAAATGTTT TGGTAACAGA AAACAATGTG
ATGAAAATAG CAGACTTTGG ACTCGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG
ACCACCAATG GGCGGCTTCC AGTCAAGTGG ATGGCTCCAG AAGCCCTGTT TGATAGAGTA
TACACTCATC AGAGTGATGT CTGGTCCTTC GGGGTGTTAA TGTGGGAGAT CTTCACTTTA
GGGGGCTCGC CCTACCCAGG GATTCCCGTG GAGGAACTTT TTAAGCTGCT GAAGGAAGGA
CACAGAATGG ATAAGCCAGC CAACTGCACC AACGAACTGT ACATGATGAT GAGGGACTGT
TGGCATGCAG TGCCCTCCCA GAGACCAACG TTCAAGCAGT TGGTAGAAGA CTTGGATCGA
ATTCTCACTC TCACAACCAA TGAGATCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu27162D
Sequence Information ORF Nucleotide Sequence (Length: 2115bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product fibroblast growth factor receptor 2 isoform 8 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039243.1, CN345547.1, U11814.1, BC037338.2 and CB305736.1. Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1. Sequence Note: A downstream AUG translation start codon is selected for this RefSeq based on the presence of a strong Kozak consensus signal, a strong community standard for the use of the downstream start codon, and on a higher probability of an N-terminal signal peptide being present in the resulting protein. The use of an alternative in-frame upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. Translation from the annotated downstream start codon is likely to occur via leaky scanning and/or reinitiation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039243.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID: 15863034) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGG AGCACCATAC
TGGACCAACA CAGAAAAGAT GGAAAAGCGG CTCCATGCTG TGCCTGCGGC CAACACTGTC
AAGTTTCGCT GCCCAGCCGG GGGGAACCCA ATGCCAACCA TGCGGTGGCT GAAAAACGGG
AAGGAGTTTA AGCAGGAGCA TCGCATTGGA GGCTACAAGG TACGAAACCA GCACTGGAGC
CTCATTATGG AAAGTGTGGT CCCATCTGAC AAGGGAAATT ATACCTGTGT AGTGGAGAAT
GAATACGGGT CCATCAATCA CACGTACCAC CTGGATGTTG TGGAGCGATC GCCTCACCGG
CCCATCCTCC AAGCCGGACT GCCGGCAAAT GCCTCCACAG TGGTCGGAGG AGACGTAGAG
TTTGTCTGCA AGGTTTACAG TGATGCCCAG CCCCACATCC AGTGGATCAA GCACGTGGAA
AAGAACGGCA GTAAATACGG GCCCGACGGG CTGCCCTACC TCAAGGTTCT CAAGGCCGCC
GGTGTTAACA CCACGGACAA AGAGATTGAG GTTCTCTATA TTCGGAATGT AACTTTTGAG
GACGCTGGGG AATATACGTG CTTGGCGGGT AATTCTATTG GGATATCCTT TCACTCTGCA
TGGTTGACAG TTCTGCCAGC GCCTGGAAGA GAAAAGGAGA TTACAGCTTC CCCAGACTAC
CTGGAGATAG CCATTTACTG CATAGGGGTC TTCTTAATCG CCTGTATGGT GGTAACAGTC
ATCCTGTGCC GAATGAAGAA CACGACCAAG AAGCCAGACT TCAGCAGCCA GCCGGCTGTG
CACAAGCTGA CCAAACGTAT CCCCCTGCGG AGACAGGTTT CGGCTGAGTC CAGCTCCTCC
ATGAACTCCA ACACCCCGCT GGTGAGGATA ACAACACGCC TCTCTTCAAC GGCAGACACC
CCCATGCTGG CAGGGGTCTC CGAGTATGAA CTTCCAGAGG ACCCAAAATG GGAGTTTCCA
AGAGATAAGC TGACACTGGG CAAGCCCCTG GGAGAAGGTT GCTTTGGGCA AGTGGTCATG
GCGGAAGCAG TGGGAATTGA CAAAGACAAG CCCAAGGAGG CGGTCACCGT GGCCGTGAAG
ATGTTGAAAG ATGATGCCAC AGAGAAAGAC CTTTCTGATC TGGTGTCAGA GATGGAGATG
ATGAAGATGA TTGGGAAACA CAAGAATATC ATAAATCTTC TTGGAGCCTG CACACAGGAT
GGGCCTCTCT ATGTCATAGT TGAGTATGCC TCTAAAGGCA ACCTCCGAGA ATACCTCCGA
GCCCGGAGGC CACCCGGGAT GGAGTACTCC TATGACATTA ACCGTGTTCC TGAGGAGCAG
ATGACCTTCA AGGACTTGGT GTCATGCACC TACCAGCTGG CCAGAGGCAT GGAGTACTTG
GCTTCCCAAA AATGTATTCA TCGAGATTTA GCAGCCAGAA ATGTTTTGGT AACAGAAAAC
AATGTGATGA AAATAGCAGA CTTTGGACTC GCCAGAGATA TCAACAATAT AGACTATTAC
AAAAAGACCA CCAATGGGCG GCTTCCAGTC AAGTGGATGG CTCCAGAAGC CCTGTTTGAT
AGAGTATACA CTCATCAGAG TGATGTCTGG TCCTTCGGGG TGTTAATGTG GGAGATCTTC
ACTTTAGGGG GCTCGCCCTA CCCAGGGATT CCCGTGGAGG AACTTTTTAA GCTGCTGAAG
GAAGGACACA GAATGGATAA GCCAGCCAAC TGCACCAACG AACTGTACAT GATGATGAGG
GACTGTTGGC ATGCAGTGCC CTCCCAGAGA CCAACGTTCA AGCAGTTGGT AGAAGACTTG
GATCGAATTC TCACTCTCAC AACCAATGAG GAATACTTGG ACCTCAGCCA ACCTCTCGAA
CAGTATTCAC CTAGTTACCC TGACACAAGA AGTTCTTGTT CTTCAGGAGA TGATTCTGTT
TTTTCTCCAG ACCCCATGCC TTACGAACCA TGCCTTCCTC AGTATCCACA CATAAACGGC
AGTGTTAAAA CATGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001138390.1
CDS648..2762
Misc Feature(1)531..533(+)
Misc Feature(2)591..593(+)
Misc Feature(3)792..1046(+)
Misc Feature(4)798..812(+)
Misc Feature(5)801..836(+)
Misc Feature(6)819..1016(+)
Misc Feature(7)1089..1379(+)
Misc Feature(8)1113..1382(+)
Misc Feature(9)1140..1340(+)
Misc Feature(10)1662..2600(+)
Misc Feature(11)1737..2567(+)
Misc Feature(12)1755..2423(+)
Misc Feature(13)1755..2228(+)
Misc Feature(14)2172..2423(+)
Misc Feature(15)2223..2300(+)
Exon (1)1..497
Gene:FGFR2
Gene Synonym:
Exon (2)498..756
Gene:FGFR2
Gene Synonym:
Exon (3)757..926
Gene:FGFR2
Gene Synonym:
Exon (4)927..1050
Gene:FGFR2
Gene Synonym:
Exon (5)1051..1241
Gene:FGFR2
Gene Synonym:
Exon (6)1242..1386
Gene:FGFR2
Gene Synonym:
Exon (7)1387..1583
Gene:FGFR2
Gene Synonym:
Exon (8)1584..1735
Gene:FGFR2
Gene Synonym:
Exon (9)1736..1857
Gene:FGFR2
Gene Synonym:
Exon (10)1858..1968
Gene:FGFR2
Gene Synonym:
Exon (11)1969..2159
Gene:FGFR2
Gene Synonym:
Exon (12)2160..2282
Gene:FGFR2
Gene Synonym:
Exon (13)2283..2353
Gene:FGFR2
Gene Synonym:
Exon (14)2354..2491
Gene:FGFR2
Gene Synonym:
Exon (15)2492..2597
Gene:FGFR2
Gene Synonym:
Exon (16)2598..4289
Gene:FGFR2
Gene Synonym:
Translation
Position Chain Variation Link
22 22 a, c dbSNP:549524538
77 77 c, t dbSNP:41301041
190 190 a, c dbSNP:41301043
227 227 c, t dbSNP:567128020
252 252 c, g dbSNP:547319962
277 277 a, c, g dbSNP:527570655
289 289 c, t dbSNP:564784147
290 290 c, t dbSNP:41301545
296 296 c, t dbSNP:772658678
311 311 a, g dbSNP:531721871
330 330 c, g dbSNP:41301547
351 351 -, cc dbSNP:41301549
410 410 c, t dbSNP:542734413
412 412 a, c, g dbSNP:1047111
475 475 a, g dbSNP:540975865
491 491 a, g dbSNP:41258305
501 501 c, t dbSNP:769814958
509 509 a, g dbSNP:574834089
513 513 c, t dbSNP:554557891
520 520 a, g dbSNP:547739869
540 540 c, t dbSNP:540720034
541 541 g, t dbSNP:761776466
552 552 g, t dbSNP:775497340
557 557 g, t dbSNP:769902826
558 558 c, t dbSNP:759690410
559 559 a, c, g dbSNP:771307977
561 561 a, g dbSNP:747423954
566 566 c, t dbSNP:778082131
570 570 g, t dbSNP:772523670
572 572 c, t dbSNP:748677100
573 573 c, t dbSNP:41287990
574 574 a, g dbSNP:4647922
576 576 -, agaggaagt dbSNP:780553051
577 577 a, g dbSNP:748929124
582 582 a, g dbSNP:779800206
586 586 -, t dbSNP:770287475
587 587 g, t dbSNP:3135721
601 601 c, t dbSNP:755803072
602 602 a, g dbSNP:201606812
607 607 a, c dbSNP:767413285
611 611 c, g dbSNP:757197396
617 617 c, t dbSNP:751455486
624 624 a, g dbSNP:765236201
628 628 c, t dbSNP:759620495
629 629 a, g dbSNP:776670842
631 631 c, g dbSNP:766629665
636 636 g, t dbSNP:760884709
641 641 c, t dbSNP:773626594
642 642 a, g dbSNP:772427122
645 645 a, c dbSNP:748610621
648 648 a, g dbSNP:774885289
662 662 c, t dbSNP:768068971
663 663 c, t dbSNP:141724446
664 664 a, c, g dbSNP:3750819
670 670 g, t dbSNP:147307031
671 671 c, t dbSNP:781146007
675 675 c, g dbSNP:370122049
680 680 c, g, t dbSNP:200562301
681 681 a, g dbSNP:143978938
688 688 c, t dbSNP:753987054
697 697 c, t dbSNP:766435280
703 703 c, t dbSNP:760903123
709 709 c, t dbSNP:773358865
711 711 c, t dbSNP:377570596
712 712 a, g dbSNP:189010277
715 715 a, c dbSNP:774554190
716 716 c, t dbSNP:769243397
734 734 a, g dbSNP:749806452
741 741 a, g dbSNP:775194870
743 743 a, g dbSNP:769369328
747 747 c, g dbSNP:373546701
752 752 a, g dbSNP:780856634
755 755 a, g dbSNP:770654393
758 758 a, g dbSNP:763094016
759 759 a, g dbSNP:775743948
771 771 a, g dbSNP:770169545
775 775 a, g dbSNP:112880592
779 779 a, g dbSNP:746281842
796 796 a, g dbSNP:146244307
800 800 c, t dbSNP:777075226
803 803 c, t dbSNP:766869457
815 815 a, g dbSNP:747502119
835 835 a, g dbSNP:141796960
839 839 c, t dbSNP:139617492
845 845 c, t dbSNP:150598483
846 846 a, g, t dbSNP:200766273
851 851 g, t dbSNP:753750519
853 853 a, t dbSNP:202212545
854 854 a, c, g dbSNP:750312209
858 858 a, g dbSNP:55977237
859 859 c, t dbSNP:755793
863 863 a, g dbSNP:775411475
868 868 c, t dbSNP:761753706
870 870 c, t dbSNP:147987917
871 871 a, g dbSNP:759750319
877 877 a, t dbSNP:777039355
884 884 c, t dbSNP:771218136
910 910 a, g dbSNP:747502397
918 918 a, g dbSNP:773718005
968 968 a, c dbSNP:755490768
977 977 c, g dbSNP:537758598
985 985 a, t dbSNP:146948953
988 988 a, t dbSNP:368224180
998 998 a, g, t dbSNP:1047100
1001 1001 a, g dbSNP:748983200
1002 1002 c, g dbSNP:779806520
1013 1013 c, t dbSNP:769311722
1017 1017 a, t dbSNP:555207905
1018 1018 c, t dbSNP:780846065
1020 1020 a, g dbSNP:757276690
1022 1022 c, g dbSNP:751395138
1029 1029 a, g dbSNP:778994181
1030 1030 c, t dbSNP:755001161
1031 1031 a, g dbSNP:199890227
1052 1052 a, g dbSNP:771784064
1053 1053 a, c dbSNP:748113099
1057 1057 cgc, tct dbSNP:281865420
1057 1057 cg, tt dbSNP:121918498
1057 1057 c, g, t dbSNP:79184941
1058 1058 ctt, gcc dbSNP:387907372
1058 1058 a, g dbSNP:138769323
1060 1060 c, g dbSNP:77543610
1061 1061 g, t dbSNP:3135755
1065 1065 c, t dbSNP:149200230
1067 1067 c, g dbSNP:200759234
1074 1074 c, t dbSNP:747171741
1082 1082 c, t dbSNP:778288494
1088 1088 a, g, t dbSNP:753082618
1090 1090 c, t dbSNP:779326224
1091 1091 a, g dbSNP:138315382
1101 1101 c, t dbSNP:121918505
1103 1103 c, t dbSNP:753345992
1106 1106 a, g dbSNP:765814642
1112 1112 a, c, t dbSNP:150488750
1113 1113 a, g dbSNP:183250272
1115 1115 a, g dbSNP:761649011
1119 1119 -, gac dbSNP:121918503
1121 1121 c, g, t dbSNP:140427785
1132 1132 c, t dbSNP:762937564
1135 1135 g, t dbSNP:776587763
1139 1139 a, g dbSNP:771068222
1154 1154 c, g dbSNP:747267954
1158 1158 c, t dbSNP:778094013
1160 1160 a, c dbSNP:772391649
1168 1168 a, c dbSNP:121918497
1170 1170 c, g, t dbSNP:121918501
1172 1172 c, g, t dbSNP:121918499
1176 1176 a, g dbSNP:121918500
1179 1179 c, t dbSNP:748526473
1181 1181 c, t dbSNP:55745510
1182 1182 a, g dbSNP:755453106
1193 1193 c, t dbSNP:754300987
1194 1194 a, g dbSNP:779566502
1201 1201 a, g dbSNP:755570604
1205 1205 c, t dbSNP:768862267
1208 1208 g, t dbSNP:532964975
1210 1210 c, g dbSNP:374608214
1211 1211 c, t dbSNP:761525014
1212 1212 a, g dbSNP:370877537
1214 1214 c, t dbSNP:570589620
1218 1218 c, g dbSNP:199937788
1220 1220 a, g dbSNP:762804005
1226 1226 c, t dbSNP:775459922
1227 1227 c, t dbSNP:4647921
1231 1231 a, g dbSNP:121913475
1233 1233 a, g dbSNP:771158421
1244 1244 c, g, t dbSNP:201717227
1245 1245 a, g, t dbSNP:121918504
1262 1262 a, c, g dbSNP:768112524
1264 1264 a, c dbSNP:121918510
1267 1267 a, c, g dbSNP:371141402
1285 1285 a, g dbSNP:121918493
1290 1290 c, t dbSNP:200204947
1291 1291 a, g dbSNP:199757302
1295 1295 c, t dbSNP:748837250
1303 1303 a, t dbSNP:372612885
1304 1304 c, t dbSNP:776683489
1310 1310 c, t dbSNP:769440184
1311 1311 a, c, g dbSNP:387906676
1320 1320 c, t dbSNP:121918489
1323 1323 a, c dbSNP:121918495
1325 1325 a, c, g, t dbSNP:201648220
1326 1326 a, c, t dbSNP:121918488
1327 1327 a, g dbSNP:121918487
1328 1328 c, g dbSNP:121918496
1331 1331 a, g dbSNP:559688816
1333 1333 c, g dbSNP:121918492
1334 1334 a, g dbSNP:121918491
1342 1342 c, g dbSNP:121918494
1354 1354 c, g dbSNP:121918502
1363 1363 c, g dbSNP:121918490
1364 1364 a, t dbSNP:544628754
1387 1387 c, t dbSNP:757846343
1388 1388 a, g dbSNP:151250769
1397 1397 a, g dbSNP:762873779
1398 1398 a, g dbSNP:762423026
1399 1399 a, g dbSNP:752220358
1401 1401 a, g dbSNP:775136828
1405 1405 a, t dbSNP:143645832
1412 1412 a, g dbSNP:759215543
1417 1417 c, g dbSNP:121913477
1422 1422 a, g dbSNP:776413718
1426 1426 a, g dbSNP:121913478
1433 1433 a, g dbSNP:770670545
1439 1439 c, t dbSNP:760627156
1443 1443 g, t dbSNP:387906678
1446 1446 c, t dbSNP:121913474
1450 1450 c, t dbSNP:773178450
1454 1454 a, g dbSNP:772014466
1457 1457 c, g dbSNP:531426519
1458 1458 g, t dbSNP:780167791
1464 1464 a, g dbSNP:769919776
1467 1467 a, g, t dbSNP:781714766
1469 1469 c, g dbSNP:757648006
1473 1473 a, g dbSNP:751951199
1474 1474 g, t dbSNP:387906677
1478 1478 a, g dbSNP:778187292
1493 1493 a, g dbSNP:377132080
1501 1501 a, t dbSNP:752209605
1507 1507 a, g dbSNP:764748528
1510 1510 a, c, t dbSNP:753437208
1514 1514 c, g, t dbSNP:562297920
1515 1515 a, g dbSNP:772986332
1523 1523 a, g dbSNP:771960546
1540 1540 c, t dbSNP:372348666
1541 1541 a, g dbSNP:147674677
1542 1542 a, g dbSNP:769880096
1544 1544 c, t dbSNP:746116691
1547 1547 a, g dbSNP:529337365
1553 1553 -, gctgaccaa dbSNP:781717945
1556 1556 a, g dbSNP:771248107
1568 1568 c, t dbSNP:747449724
1579 1579 a, g dbSNP:769536077
1589 1589 a, g dbSNP:748855113
1598 1598 c, t dbSNP:141297318
1599 1599 a, g dbSNP:146589618
1621 1621 a, c dbSNP:368002690
1622 1622 c, t dbSNP:184889995
1623 1623 c, g dbSNP:7078073
1624 1624 c, t dbSNP:757125418
1625 1625 a, g, t dbSNP:374423103
1626 1626 c, t dbSNP:143361368
1629 1629 a, g dbSNP:776868501
1640 1640 a, g dbSNP:766502777
1641 1641 a, g dbSNP:761012674
1644 1644 c, t dbSNP:536181987
1645 1645 a, g, t dbSNP:773245022
1657 1657 c, t dbSNP:148672240
1658 1658 a, g dbSNP:200183009
1671 1671 a, g, t dbSNP:370602437
1674 1674 c, t dbSNP:755574715
1677 1677 g, t dbSNP:745349225
1678 1678 c, t dbSNP:376451171
1680 1680 c, g dbSNP:756855939
1684 1684 a, t dbSNP:751433223
1719 1719 a, g dbSNP:777657579
1720 1720 a, g dbSNP:758417193
1725 1725 c, g dbSNP:752644307
1726 1726 c, t dbSNP:765241522
1731 1731 c, g dbSNP:760845434
1737 1737 c, t dbSNP:144116729
1744 1744 c, t dbSNP:767430380
1749 1749 a, c dbSNP:774235257
1751 1751 a, c, g dbSNP:149962204
1782 1782 a, g dbSNP:751731391
1790 1790 a, g dbSNP:764280287
1806 1806 a, g dbSNP:370273049
1821 1821 a, g dbSNP:775829173
1822 1822 a, g dbSNP:770391340
1826 1826 g, t dbSNP:759906958
1827 1827 a, g dbSNP:765066758
1828 1828 c, t dbSNP:770309121
1829 1829 a, g dbSNP:138985383
1832 1832 c, t dbSNP:777606451
1835 1835 c, t dbSNP:74160617
1841 1841 c, g, t dbSNP:778789088
1844 1844 a, g dbSNP:200522893
1853 1853 a, g dbSNP:749140651
1858 1858 a, g, t dbSNP:55689343
1861 1861 a, t dbSNP:756076618
1868 1868 a, g dbSNP:74160613
1872 1872 a, g dbSNP:121918507
1883 1883 c, t dbSNP:777772933
1906 1906 a, t dbSNP:758628019
1920 1920 a, g dbSNP:752880857
1933 1933 a, c dbSNP:765658636
1942 1942 a, g dbSNP:763017169
1943 1943 a, t dbSNP:121913476
1945 1945 c, t dbSNP:755350933
1969 1969 a, g dbSNP:761446954
1974 1974 c, t dbSNP:751077552
1982 1982 c, g dbSNP:763714394
1990 1990 a, c dbSNP:121918506
2010 2010 c, t dbSNP:371854567
2042 2042 c, t dbSNP:369850306
2043 2043 a, g dbSNP:138712692
2046 2046 a, g dbSNP:759496676
2057 2057 c, t dbSNP:147173572
2059 2059 a, c dbSNP:770827652
2063 2063 c, t dbSNP:748232060
2070 2070 c, t dbSNP:141929882
2071 2071 a, g dbSNP:768761510
2081 2081 a, g dbSNP:55724054
2084 2084 a, g dbSNP:56335660
2096 2096 c, t dbSNP:375961106
2098 2098 a, g dbSNP:780587674
2099 2099 a, g dbSNP:756595803
2111 2111 a, g dbSNP:750783841
2114 2114 c, g, t dbSNP:371395564
2136 2136 a, g dbSNP:751047267
2141 2141 a, g dbSNP:763592672
2143 2143 a, g dbSNP:762545440
2148 2148 a, g dbSNP:752349068
2156 2156 a, g dbSNP:143796403
2162 2162 c, t dbSNP:369637667
2163 2163 a, g dbSNP:775697900
2178 2178 a, g dbSNP:121918509
2198 2198 a, g dbSNP:770154701
2207 2207 c, t dbSNP:149008039
2209 2209 a, g dbSNP:777169135
2219 2219 a, g dbSNP:771278654
2226 2226 a, g dbSNP:138631412
2231 2231 c, t dbSNP:747316497
2237 2237 c, t dbSNP:35337478
2238 2238 a, g dbSNP:121918508
2245 2245 a, g dbSNP:758829154
2256 2256 a, g dbSNP:747718232
2285 2285 g, t dbSNP:768200252
2286 2286 c, t dbSNP:113014479
2288 2288 a, g dbSNP:748763422
2297 2297 c, g dbSNP:61731218
2312 2312 a, t dbSNP:755708679
2324 2324 c, t dbSNP:766703071
2330 2330 a, g dbSNP:750244862
2331 2331 a, g dbSNP:371596204
2333 2333 a, g dbSNP:141253851
2336 2336 c, t dbSNP:751495618
2347 2347 c, g dbSNP:764102895
2352 2352 a, g dbSNP:760895785
2360 2360 c, t dbSNP:767692675
2363 2363 c, t dbSNP:369130429
2373 2373 a, g dbSNP:774682374
2374 2374 c, t dbSNP:146571201
2401 2401 c, t dbSNP:150015885
2411 2411 a, g dbSNP:763301309
2414 2414 a, g dbSNP:775097622
2420 2420 c, t dbSNP:140813163
2450 2450 a, g dbSNP:777780454
2472 2472 a, g dbSNP:776188535
2485 2485 a, g dbSNP:200453002
2486 2486 c, t dbSNP:55637244
2525 2525 c, g dbSNP:771807547
2526 2526 c, t dbSNP:747941020
2527 2527 c, t dbSNP:375719482
2528 2528 c, t dbSNP:142639988
2534 2534 c, g dbSNP:116895810
2541 2541 a, g dbSNP:754928713
2542 2542 c, t dbSNP:745947630
2546 2546 c, t dbSNP:781182356
2547 2547 a, c dbSNP:757501816
2556 2556 a, g dbSNP:751731823
2557 2557 g, t dbSNP:777950855
2572 2572 a, g dbSNP:55774317
2579 2579 c, t dbSNP:753103160
2585 2585 c, t dbSNP:41294229
2593 2593 a, g dbSNP:765724372
2598 2598 a, g dbSNP:763622845
2604 2604 c, g, t dbSNP:201752803
2607 2607 a, g dbSNP:765174665
2609 2609 c, g dbSNP:759404861
2624 2624 c, g, t dbSNP:148478597
2625 2625 a, c, g dbSNP:374993905
2633 2633 c, t dbSNP:768983108
2642 2642 g, t dbSNP:147439731
2665 2665 a, g dbSNP:780497781
2676 2676 a, g dbSNP:756718577
2695 2695 c, t dbSNP:746336453
2703 2703 a, g dbSNP:781527776
2706 2706 c, g, t dbSNP:575812178
2710 2710 a, c dbSNP:763867175
2711 2711 c, t dbSNP:558460047
2712 2712 a, c, g dbSNP:764959117
2717 2717 a, g dbSNP:371712759
2720 2720 c, g dbSNP:759496942
2722 2722 c, t dbSNP:368003279
2731 2731 a, g dbSNP:766217118
2734 2734 c, g dbSNP:567030847
2740 2740 -, ta dbSNP:771208561
2744 2744 c, t dbSNP:774232306
2745 2745 a, g dbSNP:144176428
2748 2748 a, g dbSNP:749474548
2753 2753 c, t dbSNP:140318221
2763 2763 a, g dbSNP:547079762
2768 2768 -, act dbSNP:747773151
2787 2787 -, a dbSNP:773909650
2787 2787 a, t dbSNP:764198102
2789 2789 a, t dbSNP:763130972
2790 2790 a, g, t dbSNP:775669188
2796 2796 c, t dbSNP:746532522
2819 2819 a, g dbSNP:533590230
2833 2833 a, c dbSNP:571201278
2873 2873 a, g dbSNP:574474794
2899 2899 c, g dbSNP:777204983
2903 2903 a, g dbSNP:758066441
2912 2912 a, c dbSNP:184026174
2913 2913 -, a dbSNP:768166411
2929 2929 a, g dbSNP:778501615
2935 2935 a, g, t dbSNP:753575189
2937 2937 a, g dbSNP:562615339
2945 2945 c, g dbSNP:549203570
2946 2946 c, t dbSNP:4647917
2957 2957 g, t dbSNP:560611144
2959 2959 -, a dbSNP:748777325
3003 3003 a, t dbSNP:751685012
3013 3013 c, g dbSNP:764231570
3018 3018 a, g dbSNP:763095219
3020 3020 a, t dbSNP:1047058
3021 3021 c, t dbSNP:1047057
3028 3028 g, t dbSNP:770127980
3031 3031 a, c dbSNP:760012289
3042 3042 c, t dbSNP:776792297
3044 3044 a, g dbSNP:577983786
3049 3049 c, g dbSNP:747422874
3052 3052 c, t dbSNP:3135824
3055 3055 a, g dbSNP:544250610
3056 3056 c, t dbSNP:778261181
3067 3067 c, t dbSNP:747630815
3078 3078 c, t dbSNP:575896506
3083 3083 a, g dbSNP:3135825
3086 3086 a, g dbSNP:150519853
3147 3147 a, g dbSNP:41294349
3149 3149 a, g dbSNP:570497109
3154 3154 -, a dbSNP:35819635
3165 3165 a, g dbSNP:3135826
3181 3181 c, t dbSNP:778678344
3184 3184 a, t dbSNP:553479127
3187 3187 -, atatatt dbSNP:768174116
3187 3187 a, g dbSNP:768164829
3225 3225 a, g dbSNP:373313930
3229 3229 a, c dbSNP:191969195
3231 3231 a, g dbSNP:41294351
3258 3258 -, ctct dbSNP:576432930
3259 3259 c, t dbSNP:3135827
3319 3319 a, g, t dbSNP:569964727
3327 3327 c, g dbSNP:755059517
3341 3341 c, t dbSNP:533524841
3359 3359 a, g dbSNP:748862832
3365 3365 c, t dbSNP:557758000
3366 3366 c, g dbSNP:537398850
3382 3382 a, g dbSNP:751702753
3403 3403 -, taat dbSNP:548465887
3409 3409 a, c, t dbSNP:185913671
3423 3423 -, t dbSNP:533680275
3436 3436 g, t dbSNP:566155088
3492 3492 c, g dbSNP:549293047
3499 3499 c, g dbSNP:3135828
3511 3511 -, g dbSNP:36087207
3514 3514 -, c dbSNP:34055669
3516 3516 a, g dbSNP:763304190
3537 3537 c, t dbSNP:566653185
3568 3568 c, g dbSNP:781654432
3588 3588 c, t dbSNP:546780606
3590 3590 a, g dbSNP:201270816
3636 3636 a, g dbSNP:55723405
3640 3640 -, a dbSNP:35899971
3659 3659 a, g dbSNP:757687970
3677 3677 a, g dbSNP:751837122
3683 3683 a, g dbSNP:185617859
3687 3687 c, t dbSNP:3135829
3688 3688 a, g dbSNP:181383630
3696 3696 a, g dbSNP:776274615
3713 3713 g, t dbSNP:763034342
3722 3722 c, t dbSNP:41294353
3779 3779 c, t dbSNP:752834125
3819 3819 c, t dbSNP:562090437
3888 3888 c, t dbSNP:370106008
3893 3893 a, g dbSNP:764293761
3902 3902 a, g dbSNP:189063367
3975 3975 c, t dbSNP:765345628
3976 3976 a, g dbSNP:573135661
4016 4016 a, g dbSNP:367769355
4033 4033 c, g dbSNP:553168000
4034 4034 c, g dbSNP:545961397
4063 4063 a, c, t dbSNP:71640261
4081 4081 a, g dbSNP:3135830
4126 4126 a, g dbSNP:568759526
4148 4148 a, g dbSNP:555730451
4167 4167 a, g dbSNP:535761567
4169 4169 c, t dbSNP:532417198
4240 4240 a, g dbSNP:566742541
4260 4260 -, ataaa dbSNP:566259479
4274 4274 a, g dbSNP:141765473

Target ORF information:

RefSeq Version NM_001144918
Organism Homo sapiens (human)
Definition Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001144918

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGG AGCACCATAC
TGGACCAACA CAGAAAAGAT GGAAAAGCGG CTCCATGCTG TGCCTGCGGC CAACACTGTC
AAGTTTCGCT GCCCAGCCGG GGGGAACCCA ATGCCAACCA TGCGGTGGCT GAAAAACGGG
AAGGAGTTTA AGCAGGAGCA TCGCATTGGA GGCTACAAGG TACGAAACCA GCACTGGAGC
CTCATTATGG AAAGTGTGGT CCCATCTGAC AAGGGAAATT ATACCTGTGT AGTGGAGAAT
GAATACGGGT CCATCAATCA CACGTACCAC CTGGATGTTG TGGAGCGATC GCCTCACCGG
CCCATCCTCC AAGCCGGACT GCCGGCAAAT GCCTCCACAG TGGTCGGAGG AGACGTAGAG
TTTGTCTGCA AGGTTTACAG TGATGCCCAG CCCCACATCC AGTGGATCAA GCACGTGGAA
AAGAACGGCA GTAAATACGG GCCCGACGGG CTGCCCTACC TCAAGGTTCT CAAGGCCGCC
GGTGTTAACA CCACGGACAA AGAGATTGAG GTTCTCTATA TTCGGAATGT AACTTTTGAG
GACGCTGGGG AATATACGTG CTTGGCGGGT AATTCTATTG GGATATCCTT TCACTCTGCA
TGGTTGACAG TTCTGCCAGC GCCTGGAAGA GAAAAGGAGA TTACAGCTTC CCCAGACTAC
CTGGAGATAG CCATTTACTG CATAGGGGTC TTCTTAATCG CCTGTATGGT GGTAACAGTC
ATCCTGTGCC GAATGAAGAA CACGACCAAG AAGCCAGACT TCAGCAGCCA GCCGGCTGTG
CACAAGCTGA CCAAACGTAT CCCCCTGCGG AGACAGGTTT CGGCTGAGTC CAGCTCCTCC
ATGAACTCCA ACACCCCGCT GGTGAGGATA ACAACACGCC TCTCTTCAAC GGCAGACACC
CCCATGCTGG CAGGGGTCTC CGAGTATGAA CTTCCAGAGG ACCCAAAATG GGAGTTTCCA
AGAGATAAGC TGACACTGGG CAAGCCCCTG GGAGAAGGTT GCTTTGGGCA AGTGGTCATG
GCGGAAGCAG TGGGAATTGA CAAAGACAAG CCCAAGGAGG CGGTCACCGT GGCCGTGAAG
ATGTTGAAAG ATGATGCCAC AGAGAAAGAC CTTTCTGATC TGGTGTCAGA GATGGAGATG
ATGAAGATGA TTGGGAAACA CAAGAATATC ATAAATCTTC TTGGAGCCTG CACACAGGAT
GGGCCTCTCT ATGTCATAGT TGAGTATGCC TCTAAAGGCA ACCTCCGAGA ATACCTCCGA
GCCCGGAGGC CACCCGGGAT GGAGTACTCC TATGACATTA ACCGTGTTCC TGAGGAGCAG
ATGACCTTCA AGGACTTGGT GTCATGCACC TACCAGCTGG CCAGAGGCAT GGAGTACTTG
GCTTCCCAAA AATGTATTCA TCGAGATTTA GCAGCCAGAA ATGTTTTGGT AACAGAAAAC
AATGTGATGA AAATAGCAGA CTTTGGACTC GCCAGAGATA TCAACAATAT AGACTATTAC
AAAAAGACCA CCAATGGGCG GCTTCCAGTC AAGTGGATGG CTCCAGAAGC CCTGTTTGAT
AGAGTATACA CTCATCAGAG TGATGTCTGG TCCTTCGGGG TGTTAATGTG GGAGATCTTC
ACTTTAGGGG GCTCGCCCTA CCCAGGGATT CCCGTGGAGG AACTTTTTAA GCTGCTGAAG
GAAGGACACA GAATGGATAA GCCAGCCAAC TGCACCAACG AACTGTACAT GATGATGAGG
GACTGTTGGC ATGCAGTGCC CTCCCAGAGA CCAACGTTCA AGCAGTTGGT AGAAGACTTG
GATCGAATTC TCACTCTCAC AACCAATGAG GAATACTTGG ACCTCAGCCA ACCTCTCGAA
CAGTATTCAC CTAGTTACCC TGACACAAGA AGTTCTTGTT CTTCAGGAGA TGATTCTGTT
TTTTCTCCAG ACCCCATGCC TTACGAACCA TGCCTTCCTC AGTATCCACA CATAAACGGC
AGTGTTAAAA CATGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu22401D
Sequence Information ORF Nucleotide Sequence (Length: 2043bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product fibroblast growth factor receptor 2 isoform 9 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039243.1, CN345547.1, U11814.1, AK026508.1 and AC009988.12. Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. A downstream AUG translation start codon is selected for this RefSeq based on the presence of a strong Kozak consensus signal, a strong community standard for the use of the downstream start codon, and on a higher probability of an N-terminal signal peptide being present in the resulting protein. The use of an alternative in-frame upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. Translation from the annotated downstream start codon is likely to occur via leaky scanning and/or reinitiation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026508.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID: 15863034) ##RefSeq-Attributes-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA TGCCATCTCA
TCCGGAGATG ATGAGGATGA CACCGATGGT GCGGAAGATT TTGTCAGTGA GAACAGTAAC
AACAAGAGAG CACCATACTG GACCAACACA GAAAAGATGG AAAAGCGGCT CCATGCTGTG
CCTGCGGCCA ACACTGTCAA GTTTCGCTGC CCAGCCGGGG GGAACCCAAT GCCAACCATG
CGGTGGCTGA AAAACGGGAA GGAGTTTAAG CAGGAGCATC GCATTGGAGG CTACAAGGTA
CGAAACCAGC ACTGGAGCCT CATTATGGAA AGTGTGGTCC CATCTGACAA GGGAAATTAT
ACCTGTGTAG TGGAGAATGA ATACGGGTCC ATCAATCACA CGTACCACCT GGATGTTGTG
GAGCGATCGC CTCACCGGCC CATCCTCCAA GCCGGACTGC CGGCAAATGC CTCCACAGTG
GTCGGAGGAG ACGTAGAGTT TGTCTGCAAG GTTTACAGTG ATGCCCAGCC CCACATCCAG
TGGATCAAGC ACGTGGAAAA GAACGGCAGT AAATACGGGC CCGACGGGCT GCCCTACCTC
AAGGTTCTCA AGCACTCGGG GATAAATAGT TCCAATGCAG AAGTGCTGGC TCTGTTCAAT
GTGACCGAGG CGGATGCTGG GGAATATATA TGTAAGGTCT CCAATTATAT AGGGCAGGCC
AACCAGTCTG CCTGGCTCAC TGTCCTGCCA AAACAGCAAG CGCCTGGAAG AGAAAAGGAG
ATTACAGCTT CCCCAGACTA CCTGGAGATA GCCATTTACT GCATAGGGGT CTTCTTAATC
GCCTGTATGG TGGTAACAGT CATCCTGTGC CGAATGAAGA ACACGACCAA GAAGCCAGAC
TTCAGCAGCC AGCCGGCTGT GCACAAGCTG ACCAAACGTA TCCCCCTGCG GAGACAGGTA
ACAGTTTCGG CTGAGTCCAG CTCCTCCATG AACTCCAACA CCCCGCTGGT GAGGATAACA
ACACGCCTCT CTTCAACGGC AGACACCCCC ATGCTGGCAG GGGTCTCCGA GTATGAACTT
CCAGAGGACC CAAAATGGGA GTTTCCAAGA GATAAGCTGA CACTGGGCAA GCCCCTGGGA
GAAGGTTGCT TTGGGCAAGT GGTCATGGCG GAAGCAGTGG GAATTGACAA AGACAAGCCC
AAGGAGGCGG TCACCGTGGC CGTGAAGATG TTGAAAGATG ATGCCACAGA GAAAGACCTT
TCTGATCTGG TGTCAGAGAT GGAGATGATG AAGATGATTG GGAAACACAA GAATATCATA
AATCTTCTTG GAGCCTGCAC ACAGGATGGG CCTCTCTATG TCATAGTTGA GTATGCCTCT
AAAGGCAACC TCCGAGAATA CCTCCGAGCC CGGAGGCCAC CCGGGATGGA GTACTCCTAT
GACATTAACC GTGTTCCTGA GGAGCAGATG ACCTTCAAGG ACTTGGTGTC ATGCACCTAC
CAGCTGGCCA GAGGCATGGA GTACTTGGCT TCCCAAAAAT GTATTCATCG AGATTTAGCA
GCCAGAAATG TTTTGGTAAC AGAAAACAAT GTGATGAAAA TAGCAGACTT TGGACTCGCC
AGAGATATCA ACAATATAGA CTATTACAAA AAGACCACCA ATGGGCGGCT TCCAGTCAAG
TGGATGGCTC CAGAAGCCCT GTTTGATAGA GTATACACTC ATCAGAGTGA TGTCTGGTCC
TTCGGGGTGT TAATGTGGGA GATCTTCACT TTAGGGGGCT CGCCCTACCC AGGGATTCCC
GTGGAGGAAC TTTTTAAGCT GCTGAAGGAA GGACACAGAA TGGATAAGCC AGCCAACTGC
ACCAACGAAC TGTACATGAT GATGAGGGAC TGTTGGCATG CAGTGCCCTC CCAGAGACCA
ACGTTCAAGC AGTTGGTAGA AGACTTGGAT CGAATTCTCA CTCTCACAAC CAATGAGATC
TGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001138391.1
CDS648..2690
Misc Feature(1)531..533(+)
Misc Feature(2)591..593(+)
Misc Feature(3)870..1124(+)
Misc Feature(4)876..890(+)
Misc Feature(5)879..914(+)
Misc Feature(6)897..1094(+)
Misc Feature(7)1167..1451(+)
Misc Feature(8)1191..1454(+)
Misc Feature(9)1218..1412(+)
Misc Feature(10)1749..2684(+)
Misc Feature(11)1824..2654(+)
Misc Feature(12)1842..2510(+)
Misc Feature(13)1842..2315(+)
Misc Feature(14)2259..2510(+)
Misc Feature(15)2310..2387(+)
Exon (1)1..497
Gene:FGFR2
Gene Synonym:
Exon (2)498..756
Gene:FGFR2
Gene Synonym:
Exon (3)757..834
Gene:FGFR2
Gene Synonym:
Exon (4)835..1004
Gene:FGFR2
Gene Synonym:
Exon (5)1005..1128
Gene:FGFR2
Gene Synonym:
Exon (6)1129..1319
Gene:FGFR2
Gene Synonym:
Exon (7)1320..1467
Gene:FGFR2
Gene Synonym:
Exon (8)1468..1670
Gene:FGFR2
Gene Synonym:
Exon (9)1671..1822
Gene:FGFR2
Gene Synonym:
Exon (10)1823..1944
Gene:FGFR2
Gene Synonym:
Exon (11)1945..2055
Gene:FGFR2
Gene Synonym:
Exon (12)2056..2246
Gene:FGFR2
Gene Synonym:
Exon (13)2247..2369
Gene:FGFR2
Gene Synonym:
Exon (14)2370..2440
Gene:FGFR2
Gene Synonym:
Exon (15)2441..2578
Gene:FGFR2
Gene Synonym:
Exon (16)2579..2684
Gene:FGFR2
Gene Synonym:
Exon (17)2685..3011
Gene:FGFR2
Gene Synonym:
Translation
Position Chain Variation Link
22 22 a, c dbSNP:549524538
77 77 c, t dbSNP:41301041
190 190 a, c dbSNP:41301043
227 227 c, t dbSNP:567128020
252 252 c, g dbSNP:547319962
277 277 a, c, g dbSNP:527570655
289 289 c, t dbSNP:564784147
290 290 c, t dbSNP:41301545
296 296 c, t dbSNP:772658678
311 311 a, g dbSNP:531721871
330 330 c, g dbSNP:41301547
351 351 -, cc dbSNP:41301549
410 410 c, t dbSNP:542734413
412 412 a, c, g dbSNP:1047111
475 475 a, g dbSNP:540975865
491 491 a, g dbSNP:41258305
501 501 c, t dbSNP:769814958
509 509 a, g dbSNP:574834089
513 513 c, t dbSNP:554557891
520 520 a, g dbSNP:547739869
540 540 c, t dbSNP:540720034
541 541 g, t dbSNP:761776466
552 552 g, t dbSNP:775497340
557 557 g, t dbSNP:769902826
558 558 c, t dbSNP:759690410
559 559 a, c, g dbSNP:771307977
561 561 a, g dbSNP:747423954
566 566 c, t dbSNP:778082131
570 570 g, t dbSNP:772523670
572 572 c, t dbSNP:748677100
573 573 c, t dbSNP:41287990
574 574 a, g dbSNP:4647922
576 576 -, agaggaagt dbSNP:780553051
577 577 a, g dbSNP:748929124
582 582 a, g dbSNP:779800206
586 586 -, t dbSNP:770287475
587 587 g, t dbSNP:3135721
601 601 c, t dbSNP:755803072
602 602 a, g dbSNP:201606812
607 607 a, c dbSNP:767413285
611 611 c, g dbSNP:757197396
617 617 c, t dbSNP:751455486
624 624 a, g dbSNP:765236201
628 628 c, t dbSNP:759620495
629 629 a, g dbSNP:776670842
631 631 c, g dbSNP:766629665
636 636 g, t dbSNP:760884709
641 641 c, t dbSNP:773626594
642 642 a, g dbSNP:772427122
645 645 a, c dbSNP:748610621
648 648 a, g dbSNP:774885289
662 662 c, t dbSNP:768068971
663 663 c, t dbSNP:141724446
664 664 a, c, g dbSNP:3750819
670 670 g, t dbSNP:147307031
671 671 c, t dbSNP:781146007
675 675 c, g dbSNP:370122049
680 680 c, g, t dbSNP:200562301
681 681 a, g dbSNP:143978938
688 688 c, t dbSNP:753987054
697 697 c, t dbSNP:766435280
703 703 c, t dbSNP:760903123
709 709 c, t dbSNP:773358865
711 711 c, t dbSNP:377570596
712 712 a, g dbSNP:189010277
715 715 a, c dbSNP:774554190
716 716 c, t dbSNP:769243397
734 734 a, g dbSNP:749806452
741 741 a, g dbSNP:775194870
743 743 a, g dbSNP:769369328
747 747 c, g dbSNP:373546701
752 752 a, g dbSNP:780856634
755 755 a, g dbSNP:770654393
767 767 a, t dbSNP:749651751
771 771 a, g dbSNP:780458049
773 773 a, g dbSNP:756641429
778 778 a, t dbSNP:750876096
779 779 c, g, t dbSNP:373155033
781 781 a, t dbSNP:751236652
791 791 c, t dbSNP:763704465
798 798 a, g dbSNP:762636391
799 799 c, t dbSNP:752501698
800 800 a, g dbSNP:765024365
801 801 a, g dbSNP:759550441
817 817 a, g dbSNP:776668623
822 822 a, g dbSNP:772298926
829 829 a, g dbSNP:762030875
830 830 -, caa dbSNP:752218106
833 833 c, g dbSNP:774538633
836 836 a, g dbSNP:763094016
837 837 a, g dbSNP:775743948
849 849 a, g dbSNP:770169545
853 853 a, g dbSNP:112880592
857 857 a, g dbSNP:746281842
874 874 a, g dbSNP:146244307
878 878 c, t dbSNP:777075226
881 881 c, t dbSNP:766869457
893 893 a, g dbSNP:747502119
913 913 a, g dbSNP:141796960
917 917 c, t dbSNP:139617492
923 923 c, t dbSNP:150598483
924 924 a, g, t dbSNP:200766273
929 929 g, t dbSNP:753750519
931 931 a, t dbSNP:202212545
932 932 a, c, g dbSNP:750312209
936 936 a, g dbSNP:55977237
937 937 c, t dbSNP:755793
941 941 a, g dbSNP:775411475
946 946 c, t dbSNP:761753706
948 948 c, t dbSNP:147987917
949 949 a, g dbSNP:759750319
955 955 a, t dbSNP:777039355
962 962 c, t dbSNP:771218136
988 988 a, g dbSNP:747502397
996 996 a, g dbSNP:773718005
1046 1046 a, c dbSNP:755490768
1055 1055 c, g dbSNP:537758598
1063 1063 a, t dbSNP:146948953
1066 1066 a, t dbSNP:368224180
1076 1076 a, g, t dbSNP:1047100
1079 1079 a, g dbSNP:748983200
1080 1080 c, g dbSNP:779806520
1091 1091 c, t dbSNP:769311722
1095 1095 a, t dbSNP:555207905
1096 1096 c, t dbSNP:780846065
1098 1098 a, g dbSNP:757276690
1100 1100 c, g dbSNP:751395138
1107 1107 a, g dbSNP:778994181
1108 1108 c, t dbSNP:755001161
1109 1109 a, g dbSNP:199890227
1130 1130 a, g dbSNP:771784064
1131 1131 a, c dbSNP:748113099
1135 1135 cgc, tct dbSNP:281865420
1135 1135 cg, tt dbSNP:121918498
1135 1135 c, g, t dbSNP:79184941
1136 1136 ctt, gcc dbSNP:387907372
1136 1136 a, g dbSNP:138769323
1138 1138 c, g dbSNP:77543610
1139 1139 g, t dbSNP:3135755
1143 1143 c, t dbSNP:149200230
1145 1145 c, g dbSNP:200759234
1152 1152 c, t dbSNP:747171741
1160 1160 c, t dbSNP:778288494
1166 1166 a, g, t dbSNP:753082618
1168 1168 c, t dbSNP:779326224
1169 1169 a, g dbSNP:138315382
1179 1179 c, t dbSNP:121918505
1181 1181 c, t dbSNP:753345992
1184 1184 a, g dbSNP:765814642
1190 1190 a, c, t dbSNP:150488750
1191 1191 a, g dbSNP:183250272
1193 1193 a, g dbSNP:761649011
1197 1197 -, gac dbSNP:121918503
1199 1199 c, g, t dbSNP:140427785
1210 1210 c, t dbSNP:762937564
1213 1213 g, t dbSNP:776587763
1217 1217 a, g dbSNP:771068222
1232 1232 c, g dbSNP:747267954
1236 1236 c, t dbSNP:778094013
1238 1238 a, c dbSNP:772391649
1246 1246 a, c dbSNP:121918497
1248 1248 c, g, t dbSNP:121918501
1250 1250 c, g, t dbSNP:121918499
1254 1254 a, g dbSNP:121918500
1257 1257 c, t dbSNP:748526473
1259 1259 c, t dbSNP:55745510
1260 1260 a, g dbSNP:755453106
1271 1271 c, t dbSNP:754300987
1272 1272 a, g dbSNP:779566502
1279 1279 a, g dbSNP:755570604
1283 1283 c, t dbSNP:768862267
1286 1286 g, t dbSNP:532964975
1288 1288 c, g dbSNP:374608214
1289 1289 c, t dbSNP:761525014
1290 1290 a, g dbSNP:370877537
1292 1292 c, t dbSNP:570589620
1296 1296 c, g dbSNP:199937788
1298 1298 a, g dbSNP:762804005
1304 1304 c, t dbSNP:775459922
1305 1305 c, t dbSNP:4647921
1309 1309 a, g dbSNP:121913475
1311 1311 a, g dbSNP:771158421
1321 1321 a, g dbSNP:3206759
1325 1325 a, g dbSNP:749699527
1327 1327 g, t dbSNP:1129324
1328 1328 a, g dbSNP:775831408
1329 1329 a, g, t dbSNP:1143401
1336 1336 a, g dbSNP:770347175
1342 1342 a, c dbSNP:1129323
1343 1343 g, t dbSNP:1129322
1349 1349 a, g dbSNP:369682344
1351 1351 a, t dbSNP:1129321
1352 1352 a, g, t dbSNP:756750786
1353 1353 a, c dbSNP:1129320
1359 1359 c, g dbSNP:563769835
1361 1361 a, g dbSNP:1143402
1366 1366 a, g dbSNP:777532382
1370 1370 a, g dbSNP:1129318
1373 1373 c, t dbSNP:752595302
1378 1378 a, c, t dbSNP:1047095
1379 1379 a, g dbSNP:768008676
1382 1382 c, t dbSNP:1047090
1391 1391 a, g dbSNP:753784222
1396 1396 c, t dbSNP:1047088
1397 1397 a, g dbSNP:1047087
1405 1405 g, t dbSNP:1065581
1414 1414 a, c dbSNP:1047083
1415 1415 c, t dbSNP:187206427
1418 1418 a, t dbSNP:1047082
1422 1422 a, c dbSNP:1065582
1424 1424 g, t dbSNP:1047078
1429 1429 a, t dbSNP:1047077
1433 1433 c, g dbSNP:1047076
1437 1437 g, t dbSNP:774261262
1439 1439 a, c dbSNP:1047074
1443 1443 c, t dbSNP:1129316
1445 1445 c, g dbSNP:1129314
1447 1447 c, g dbSNP:377431543
1448 1448 a, g, t dbSNP:1129313
1451 1451 a, c, t dbSNP:1129312
1463 1463 a, g dbSNP:775849795
1468 1468 c, t dbSNP:757846343
1469 1469 a, g dbSNP:151250769
1478 1478 a, g dbSNP:762873779
1479 1479 a, g dbSNP:762423026
1480 1480 a, g dbSNP:752220358
1482 1482 a, g dbSNP:775136828
1486 1486 a, t dbSNP:143645832
1493 1493 a, g dbSNP:759215543
1498 1498 c, g dbSNP:121913477
1503 1503 a, g dbSNP:776413718
1507 1507 a, g dbSNP:121913478
1514 1514 a, g dbSNP:770670545
1520 1520 c, t dbSNP:760627156
1524 1524 g, t dbSNP:387906678
1527 1527 c, t dbSNP:121913474
1531 1531 c, t dbSNP:773178450
1535 1535 a, g dbSNP:772014466
1538 1538 c, g dbSNP:531426519
1539 1539 g, t dbSNP:780167791
1545 1545 a, g dbSNP:769919776
1548 1548 a, g, t dbSNP:781714766
1550 1550 c, g dbSNP:757648006
1554 1554 a, g dbSNP:751951199
1555 1555 g, t dbSNP:387906677
1559 1559 a, g dbSNP:778187292
1574 1574 a, g dbSNP:377132080
1582 1582 a, t dbSNP:752209605
1588 1588 a, g dbSNP:764748528
1591 1591 a, c, t dbSNP:753437208
1595 1595 c, g, t dbSNP:562297920
1596 1596 a, g dbSNP:772986332
1604 1604 a, g dbSNP:771960546
1621 1621 c, t dbSNP:372348666
1622 1622 a, g dbSNP:147674677
1623 1623 a, g dbSNP:769880096
1625 1625 c, t dbSNP:746116691
1628 1628 a, g dbSNP:529337365
1634 1634 -, gctgaccaa dbSNP:781717945
1637 1637 a, g dbSNP:771248107
1649 1649 c, t dbSNP:747449724
1660 1660