The following AAK1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AAK1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 2886bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||AP2-associated protein kinase 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AW451954.1, DB285703.1,
BC111965.1, DA121999.1, AW969393.1, AC136007.3, AC114772.5 and
On or before May 25, 2007 this sequence version replaced
gi:113413001, gi:113413846, gi:29570779.
Summary: Adaptor-related protein complex 2 (AP-2 complexes)
functions during receptor-mediated endocytosis to trigger clathrin
assembly, interact with membrane-bound receptors, and recruit
encodytic accessory factors. This gene encodes a member of the SNF1
subfamily of Ser/Thr protein kinases. The protein interacts with
and phosphorylates a subunit of the AP-2 complex, which promotes
binding of AP-2 to sorting signals found in membrane-bound
receptors and subsequent receptor endocytosis. Its kinase activity
is stimulated by clathrin. Alternatively spliced transcript
variants have been described, but their biological validity has not
been determined. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
RNAseq introns :: mixed/partial sample support SAMEA1965299,
inferred exon combination :: based on alignments, homology
COMPLETENESS: complete on the 3' end.