The following ALDOB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALDOB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1095bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||fructose-bisphosphate aldolase B
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X02747.1, AL353621.19 and
This sequence is a reference standard in the RefSeqGene project.
On Dec 19, 2008 this sequence version replaced gi:40354204.
Summary: Fructose-1,6-bisphosphate aldolase (EC 220.127.116.11) is a
tetrameric glycolytic enzyme that catalyzes the reversible
conversion of fructose-1,6-bisphosphate to glyceraldehyde
3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3
aldolase isozymes which are distinguished by their electrophoretic
and catalytic properties. Differences indicate that aldolases A, B,
and C are distinct proteins, the products of a family of related
'housekeeping' genes exhibiting developmentally regulated
expression of the different isozymes. The developing embryo
produces aldolase A, which is produced in even greater amounts in
adult muscle where it can be as much as 5% of total cellular
protein. In adult liver, kidney and intestine, aldolase A
expression is repressed and aldolase B is produced. In brain and
other nervous tissue, aldolase A and C are expressed about equally.
There is a high degree of homology between aldolase A and C.
Defects in ALDOB cause hereditary fructose intolerance. [provided
by RefSeq, Dec 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: X02747.1, X01098.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.