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FOXG1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol FOXG1
Entrez Gene ID 2290
Full Name forkhead box G1
Synonyms BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF-3, HBF-G2, HBF2, HFK1, HFK2, HFK3, KHL2, QIN
General protein information
Preferred Names
forkhead box protein G1
Names
forkhead box protein G1
oncogene QIN
brain factor 1
brain factor 2
forkhead-like 1
forkhead-like 2
forkhead-like 3
forkhead-like 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q13

Summary This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]. lac of sum
Disorder MIM:

164874

Disorder Html: Rett syndrome, congenital variant, 613454 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_005249 NP_005240 forkhead box protein G1



Homo sapiens (human) FOXG1 NP_005240.3
Pan troglodytes (chimpanzee) FOXG1 XP_003952518.1
Macaca mulatta (Rhesus monkey) LOC716287 XP_001106922.2
Bos taurus (cattle) FOXG1 XP_002707820.2
Mus musculus (house mouse) Foxg1 NP_032267.1
Rattus norvegicus (Norway rat) Foxg1 NP_036692.1
Danio rerio (zebrafish) foxg1a NP_571142.1
Xenopus (Silurana) tropicalis (western clawed frog) foxg1 NP_001116933.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOXG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22100 NM_005249 Homo sapiens forkhead box G1 (FOXG1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22100
Clone ID Related Accession (Same CDS sequence) NM_005249
Accession Version NM_005249.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1470bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Product forkhead box protein G1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X74142.1, DR001113.1, BC035020.2, AL049777.5 and U44097.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2012 this sequence version replaced gi:32307176. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC 
AACAGCCTGG TGCCCGAGGC GGTCCAGAAC GACAACCACC ACGCGAGCCA CGGCCACCAC
AACAGCCACC ACCCCCAGCA CCACCACCAC CACCACCACC ATCACCACCA CCCGCCGCCG
CCCGCCCCGC AACCGCCGCC GCCGCCGCAG CAGCAGCAGC CGCCGCCGCC GCCGCCCCCG
GCACCGCAGC CCCCCCAGAC GCGGGGCGCC CCGGCCGCCG ACGACGACAA GGGCCCCCAG
CAGCTGCTGC TCCCGCCGCC GCCACCGCCA CCACCGGCCG CCGCCCTGGA CGGGGCTAAA
GCGGACGGGC TGGGCGGCAA GGGCGAGCCG GGCGGCGGGC CGGGGGAGCT GGCGCCCGTC
GGGCCGGACG AGAAGGAGAA GGGCGCCGGC GCCGGGGGGG AGGAGAAGAA GGGGGCGGGC
GAGGGCGGCA AGGACGGGGA GGGGGGCAAG GAGGGCGAGA AGAAGAACGG CAAGTACGAG
AAGCCGCCGT TCAGCTACAA CGCGCTCATC ATGATGGCCA TCCGGCAGAG CCCCGAGAAG
CGGCTCACGC TCAACGGCAT CTACGAGTTC ATCATGAAGA ACTTCCCTTA CTACCGCGAG
AACAAGCAGG GCTGGCAGAA CTCCATCCGC CACAATCTGT CCCTCAACAA GTGCTTCGTG
AAGGTGCCGC GCCACTACGA CGACCCGGGC AAGGGCAACT ACTGGATGCT GGACCCGTCG
AGCGACGACG TGTTCATCGG CGGCACCACG GGCAAGCTGC GGCGCCGCTC CACCACCTCG
CGGGCCAAGC TGGCCTTCAA GCGCGGTGCG CGCCTCACCT CCACCGGCCT CACCTTCATG
GACCGCGCCG GCTCCCTCTA CTGGCCCATG TCGCCCTTCC TGTCCCTGCA CCACCCCCGC
GCCAGCAGCA CTTTGAGTTA CAACGGCACC ACGTCGGCCT ACCCCAGCCA CCCCATGCCC
TACAGCTCCG TGTTGACTCA GAACTCGCTG GGCAACAACC ACTCCTTCTC CACCGCCAAC
GGCCTGAGCG TGGACCGGCT GGTCAACGGG GAGATCCCGT ACGCCACGCA CCACCTCACG
GCCGCCGCGC TAGCCGCCTC GGTGCCCTGC GGCCTGTCGG TGCCCTGCTC TGGGACCTAC
TCCCTCAACC CCTGCTCCGT CAACCTGCTC GCGGGCCAGA CCAGTTACTT TTTCCCCCAC
GTCCCGCACC CGTCAATGAC TTCGCAGAGC AGCACGTCCA TGAGCGCCAG GGCCGCGTCC
TCCTCCACGT CGCCGCAGGC CCCCTCGACC CTGCCCTGTG AGTCTTTAAG ACCCTCTTTG
CCAAGTTTTA CGACGGGACT GTCTGGGGGA CTGTCTGATT ATTTCACACA TCAAAATCAG
GGGTCTTCTT CCAACCCTTT AATACATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005240.3
CDS209..1678
Misc Feature(1)35..37(+)
Misc Feature(2)749..982(+)
Misc Feature(3)857..961(+)
Misc Feature(4)1355..1426(+)
Exon (1)1..3206
Gene:FOXG1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005249
Organism Homo sapiens (human)
Definition Homo sapiens forkhead box G1 (FOXG1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005249

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC 
AACAGCCTGG TGCCCGAGGC GGTCCAGAAC GACAACCACC ACGCGAGCCA CGGCCACCAC
AACAGCCACC ACCCCCAGCA CCACCACCAC CACCACCACC ATCACCACCA CCCGCCGCCG
CCCGCCCCGC AACCGCCGCC GCCGCCGCAG CAGCAGCAGC CGCCGCCGCC GCCGCCCCCG
GCACCGCAGC CCCCCCAGAC GCGGGGCGCC CCGGCCGCCG ACGACGACAA GGGCCCCCAG
CAGCTGCTGC TCCCGCCGCC GCCACCGCCA CCACCGGCCG CCGCCCTGGA CGGGGCTAAA
GCGGACGGGC TGGGCGGCAA GGGCGAGCCG GGCGGCGGGC CGGGGGAGCT GGCGCCCGTC
GGGCCGGACG AGAAGGAGAA GGGCGCCGGC GCCGGGGGGG AGGAGAAGAA GGGGGCGGGC
GAGGGCGGCA AGGACGGGGA GGGGGGCAAG GAGGGCGAGA AGAAGAACGG CAAGTACGAG
AAGCCGCCGT TCAGCTACAA CGCGCTCATC ATGATGGCCA TCCGGCAGAG CCCCGAGAAG
CGGCTCACGC TCAACGGCAT CTACGAGTTC ATCATGAAGA ACTTCCCTTA CTACCGCGAG
AACAAGCAGG GCTGGCAGAA CTCCATCCGC CACAATCTGT CCCTCAACAA GTGCTTCGTG
AAGGTGCCGC GCCACTACGA CGACCCGGGC AAGGGCAACT ACTGGATGCT GGACCCGTCG
AGCGACGACG TGTTCATCGG CGGCACCACG GGCAAGCTGC GGCGCCGCTC CACCACCTCG
CGGGCCAAGC TGGCCTTCAA GCGCGGTGCG CGCCTCACCT CCACCGGCCT CACCTTCATG
GACCGCGCCG GCTCCCTCTA CTGGCCCATG TCGCCCTTCC TGTCCCTGCA CCACCCCCGC
GCCAGCAGCA CTTTGAGTTA CAACGGCACC ACGTCGGCCT ACCCCAGCCA CCCCATGCCC
TACAGCTCCG TGTTGACTCA GAACTCGCTG GGCAACAACC ACTCCTTCTC CACCGCCAAC
GGCCTGAGCG TGGACCGGCT GGTCAACGGG GAGATCCCGT ACGCCACGCA CCACCTCACG
GCCGCCGCGC TAGCCGCCTC GGTGCCCTGC GGCCTGTCGG TGCCCTGCTC TGGGACCTAC
TCCCTCAACC CCTGCTCCGT CAACCTGCTC GCGGGCCAGA CCAGTTACTT TTTCCCCCAC
GTCCCGCACC CGTCAATGAC TTCGCAGAGC AGCACGTCCA TGAGCGCCAG GGCCGCGTCC
TCCTCCACGT CGCCGCAGGC CCCCTCGACC CTGCCCTGTG AGTCTTTAAG ACCCTCTTTG
CCAAGTTTTA CGACGGGACT GTCTGGGGGA CTGTCTGATT ATTTCACACA TCAAAATCAG
GGGTCTTCTT CCAACCCTTT AATACATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells
Mol. Endocrinol. 27 (7), 1113-1127 (2013)
Li JV, Chien CD, Garee JP, Xu J, Wellstein A and Riegel AT.


book

14q12 microdeletions excluding FOXG1 give rise to a congenital variant Rett syndrome-like phenotype
Eur. J. Hum. Genet. 21 (5), 522-527 (2013)
Ellaway CJ, Ho G, Bettella E, Knapman A, Collins F, Hackett A, McKenzie F, Darmanian A, Peters GB, Fagan K and Christodoulou J.


book

14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements
Eur. J. Hum. Genet. 20 (12), 1216-1223 (2012)
Allou L, Lambert L, Amsallem D, Bieth E, Edery P, Destree A, Rivier F, Amor D, Thompson E, Nicholl J, Harbord M, Nemos C, Saunier A, Moustaine A, Vigouroux A, Jonveaux P and Philippe C.


book

Further delineation of the phenotype of chromosome 14q13 deletions: (positional) involvement of FOXG1 appears the main determinant of phenotype severity, with no evidence for a holoprosencephaly locus
J. Med. Genet. 49 (6), 366-372 (2012)
Santen GW, Sun Y, Gijsbers AC, Carre A, Holvoet M, Haeringen Av, Lesnik Oberstein SA, Tomoda A, Mabe H, Polak M, Devriendt K, Ruivenkamp CA and Bijlsma EK.


book

The oncogene qin codes for a transcriptional repressor
Cancer Res. 55 (23), 5540-5544 (1995)
Li J, Chang HW, Lai E, Parker EJ and Vogt PK.


book

The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q
Biochim. Biophys. Acta 1262 (2-3), 105-112 (1995)
Wiese S, Murphy DB, Schlung A, Burfeind P, Schmundt D, Schnulle V, Mattei MG and Thies U.


book

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
EMBO J. 13 (20), 5002-5012 (1994)
Pierrou S, Hellqvist M, Samuelsson L, Enerback S and Carlsson P.


book

Human brain factor 1, a new member of the fork head gene family
Genomics 21 (3), 551-557 (1994)
Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W and Thies U.


book

The human homologue of the retroviral oncogene qin maps to chromosome 14q13
Proc. Natl. Acad. Sci. U.S.A. 91 (9), 3616-3618 (1994)
Kastury K, Li J, Druck T, Su H, Vogt PK, Croce CM and Huebner K.


book

The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head
Proc. Natl. Acad. Sci. U.S.A. 90 (10), 4490-4494 (1993)
Li J and Vogt PK.


 
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