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FOXE3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol FOXE3
Entrez Gene ID 2301
Full Name forkhead box E3
Synonyms FKHL12, FREAC8
General protein information
Preferred Names
forkhead box protein E3
Names
forkhead box protein E3
FREAC-8
forkhead-related protein FKHL12
forkhead, drosophila, homolog-like 12
forkhead-related transcription factor 8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p32

Summary This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]. lac of sum
Disorder MIM:

601094

Disorder Html: Anterior segment mesenchymal dysgenesis, 107250 (3); Aphakia,

mRNA and Protein(s)

mRNA Protein Name
NM_012186 NP_036318 forkhead box protein E3


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOXE3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXE3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu17850 NM_012186 Homo sapiens forkhead box E3 (FOXE3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17850
Clone ID Related Accession (Same CDS sequence) NM_012186
Accession Version NM_012186.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 960bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product forkhead box protein E3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF275722.1 and AL607122.20. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2006 this sequence version replaced gi:11386196. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF275722.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036318.1
CDS245..1204
Misc Feature(1)185..187(+)
Misc Feature(2)455..688(+)
Misc Feature(3)563..667(+)
Exon (1)1..1981
Gene:FOXE3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_012186
Organism Homo sapiens (human)
Definition Homo sapiens forkhead box E3 (FOXE3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012186

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

An epidemiological investigation of a Forkhead box protein E3 founder mutation underlying the high frequency of sclerocornea, aphakia, and microphthalmia in a Mexican village
Mol. Vis. 19, 1866-1870 (2013)
Pantoja-Melendez C, Ali M and Zenteno JC.


book

Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3)
Graefes Arch. Clin. Exp. Ophthalmol. 250 (7), 999-1007 (2012)
Wang Y, Li W, Wang Y and Huang Y.


book

A novel, non-stop mutation in FOXE3 causes an autosomal dominant form of variable anterior segment dysgenesis including Peters anomaly
Eur. J. Hum. Genet. 19 (3), 293-299 (2011)
Doucette L, Green J, Fernandez B, Johnson GJ, Parfrey P and Young TL.


book

Targeted 'next-generation' sequencing in anophthalmia and microphthalmia patients confirms SOX2, OTX2 and FOXE3 mutations
BMC Med. Genet. 12, 172 (2011)
Jimenez NL, Flannick J, Yahyavi M, Li J, Bardakjian T, Tonkin L, Schneider A, Sherr EH and Slavotinek AM.


book

Identification of dominant FOXE3 and PAX6 mutations in patients with congenital cataract and aniridia
Mol. Vis. 16, 1705-1711 (2010)
Bremond-Gignac D, Bitoun P, Reis LM, Copin H, Murray JC and Semina EV.


book

Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies
Hum. Mutat. 30 (10), 1378-1386 (2009)
Iseri SU, Osborne RJ, Farrall M, Wyatt AW, Mirza G, Nurnberg G, Kluck C, Herbert H, Martin A, Hussain MS, Collin JR, Lathrop M, Nurnberg P, Ragoussis J and Ragge NK.


book

Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans
Am. J. Hum. Genet. 79 (2), 358-364 (2006)
Valleix S, Niel F, Nedelec B, Algros MP, Schwartz C, Delbosc B, Delpech M and Kantelip B.


book

Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts
Hum. Mol. Genet. 10 (3), 231-236 (2001)
Semina EV, Brownell I, Mintz-Hittner HA, Murray JC and Jamrich M.


book

A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle
Genes Dev. 14 (2), 245-254 (2000)
Blixt A, Mahlapuu M, Aitola M, Pelto-Huikko M, Enerback S and Carlsson P.


book

Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)
Genomics 30 (3), 464-469 (1995)
Larsson C, Hellqvist M, Pierrou S, White I, Enerback S and Carlsson P.


 
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