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TARDBP TAR DNA binding protein [Homo sapiens (human)]

Gene Symbol TARDBP
Entrez Gene ID 23435
Full Name TAR DNA binding protein
Synonyms ALS10, TDP-43
General protein information
Preferred Names
TAR DNA-binding protein 43
Names
TAR DNA-binding protein 43
TAR DNA-binding protein-43
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.22

Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

605078

Disorder Html: Amyotrophic lateral sclerosis 10, with or without FTD, 612069 (3);





The following TARDBP gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TARDBP gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19093 NM_007375 Homo sapiens TAR DNA binding protein (TARDBP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19093
Accession Version NM_007375.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1245bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product TAR DNA-binding protein 43
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI464234.1, CD703666.1, BC001487.2, AL050265.1, AL045296.1, BC059955.1, AF311304.1 and BM716882.1. This sequence is a reference standard in the RefSeqGene project. On or before Feb 23, 2004 this sequence version replaced gi:13654285, gi:19743843. Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001487.2, AL050265.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGTCTGAAT ATATTCGGGT AACCGAAGAT GAGAACGATG AGCCCATTGA AATACCATCG 
GAAGACGATG GGACGGTGCT GCTCTCCACG GTTACAGCCC AGTTTCCAGG GGCGTGTGGG
CTTCGCTACA GGAATCCAGT GTCTCAGTGT ATGAGAGGTG TCCGGCTGGT AGAAGGAATT
CTGCATGCCC CAGATGCTGG CTGGGGAAAT CTGGTGTATG TTGTCAACTA TCCAAAAGAT
AACAAAAGAA AAATGGATGA GACAGATGCT TCATCAGCAG TGAAAGTGAA AAGAGCAGTC
CAGAAAACAT CCGATTTAAT AGTGTTGGGT CTCCCATGGA AAACAACCGA ACAGGACCTG
AAAGAGTATT TTAGTACCTT TGGAGAAGTT CTTATGGTGC AGGTCAAGAA AGATCTTAAG
ACTGGTCATT CAAAGGGGTT TGGCTTTGTT CGTTTTACGG AATATGAAAC ACAAGTGAAA
GTAATGTCAC AGCGACATAT GATAGATGGA CGATGGTGTG ACTGCAAACT TCCTAATTCT
AAGCAAAGCC AAGATGAGCC TTTGAGAAGC AGAAAAGTGT TTGTGGGGCG CTGTACAGAG
GACATGACTG AGGATGAGCT GCGGGAGTTC TTCTCTCAGT ACGGGGATGT GATGGATGTC
TTCATCCCCA AGCCATTCAG GGCCTTTGCC TTTGTTACAT TTGCAGATGA TCAGATTGCG
CAGTCTCTTT GTGGAGAGGA CTTGATCATT AAAGGAATCA GCGTTCATAT ATCCAATGCC
GAACCTAAGC ACAATAGCAA TAGACAGTTA GAAAGAAGTG GAAGATTTGG TGGTAATCCA
GGTGGCTTTG GGAATCAGGG TGGATTTGGT AATAGCAGAG GGGGTGGAGC TGGTTTGGGA
AACAATCAAG GTAGTAATAT GGGTGGTGGG ATGAACTTTG GTGCGTTCAG CATTAATCCA
GCCATGATGG CTGCCGCCCA GGCAGCACTA CAGAGCAGTT GGGGTATGAT GGGCATGTTA
GCCAGCCAGC AGAACCAGTC AGGCCCATCG GGTAATAACC AAAACCAAGG CAACATGCAG
AGGGAGCCAA ACCAGGCCTT CGGTTCTGGA AATAACTCTT ATAGTGGCTC TAATTCTGGT
GCAGCAATTG GTTGGGGATC AGCATCCAAT GCAGGGTCGG GCAGTGGTTT TAATGGAGGC
TTTGGCTCAA GCATGGATTC TAAGTCTTCT GGCTGGGGAA TGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_031401.1
CDS135..1379
Misc Feature(1)129..131(+)
Misc Feature(2)405..407(+)
Misc Feature(3)408..410(+)
Misc Feature(4)447..677(+)
Misc Feature(5)450..659(+)
Misc Feature(6)603..605(+)
Misc Feature(7)705..917(+)
Misc Feature(8)708..917(+)
Misc Feature(9)711..890(+)
Misc Feature(10)1008..1010(+)
Exon (1)1..122
Gene:TARDBP
Gene Synonym:
Exon (2)123..372
Gene:TARDBP
Gene Synonym:
Exon (3)373..536
Gene:TARDBP
Gene Synonym:
Exon (4)537..677
Gene:TARDBP
Gene Synonym:
Exon (5)678..848
Gene:TARDBP
Gene Synonym:
Exon (6)849..4217
Gene:TARDBP
Gene Synonym:
Translation
Position Chain Variation Link
1 1 g, t dbSNP:538155108
13 13 a, g dbSNP:11121679
25 25 c, t dbSNP:577981181
27 27 a, c dbSNP:545055968
40 40 a, g dbSNP:553792909
73 73 c, t dbSNP:572152041
97 97 c, t dbSNP:542310946
113 113 a, g dbSNP:756901478
126 126 a, g dbSNP:531845599
130 130 a, g dbSNP:200517396
132 132 a, g dbSNP:528142716
158 158 c, t dbSNP:72870030
164 164 c, t dbSNP:140008847
170 170 c, t dbSNP:565091566
176 176 a, g dbSNP:748698993
191 191 a, g dbSNP:532319219
200 200 c, t dbSNP:773358415
201 201 a, g dbSNP:375089732
206 206 a, g dbSNP:766620483
215 215 a, g dbSNP:776777703
218 218 c, t dbSNP:369718876
221 221 c, t dbSNP:201693535
224 224 g, t dbSNP:111671110
229 229 c, t dbSNP:752580444
248 248 a, c, g dbSNP:535276506
254 254 c, g dbSNP:758344713
275 275 a, g dbSNP:763441783
296 296 c, t dbSNP:751073315
299 299 a, g dbSNP:756772204
300 300 c, t dbSNP:780873066
327 327 -, t dbSNP:35714982
329 329 a, t dbSNP:80356716
332 332 c, t dbSNP:61730366
335 335 c, t dbSNP:755357622
341 341 a, g dbSNP:779446284
345 345 c, g dbSNP:748612906
361 361 a, g dbSNP:142913423
396 396 a, g dbSNP:778322559
401 401 a, t dbSNP:747512757
403 403 c, g, t dbSNP:80356715
407 407 a, g dbSNP:369009972
409 409 a, c, t dbSNP:11547736
415 415 c, t dbSNP:775743535
416 416 a, g dbSNP:11547735
420 420 a, g dbSNP:762711471
445 445 c, g dbSNP:368273954
446 446 c, t dbSNP:774307145
464 464 g, t dbSNP:199804130
470 470 a, g dbSNP:373324166
491 491 c, t dbSNP:749962069
508 508 a, g dbSNP:760327879
532 532 g, t dbSNP:766116483
535 535 a, g dbSNP:201738296
545 545 a, g dbSNP:766028449
549 549 c, g dbSNP:776384568
586 586 a, g dbSNP:759121939
640 640 a, g dbSNP:80356717
641 641 c, t dbSNP:764451101
647 647 a, t dbSNP:751865832
704 704 c, t dbSNP:147772554
716 716 c, t dbSNP:778984433
731 731 a, c dbSNP:748445941
734 734 a, g dbSNP:375128760
766 766 c, t dbSNP:199933965
776 776 c, t dbSNP:138201492
782 782 c, t dbSNP:777735387
798 798 a, c dbSNP:61742415
803 803 c, g dbSNP:149517613
809 809 a, g dbSNP:61741294
827 827 c, t dbSNP:781245236
833 833 a, c dbSNP:745343269
854 854 a, g dbSNP:765175133
896 896 c, t dbSNP:752815065
908 908 c, t dbSNP:763180944
911 911 c, t dbSNP:764385204
915 915 a, g, t dbSNP:17849488
921 921 a, g dbSNP:267607102
926 926 c, t dbSNP:528733699
934 934 a, g dbSNP:80356718
935 935 c, t dbSNP:370069646
940 940 -, agtt dbSNP:769139013
942 942 c, t dbSNP:750267756
951 951 a, t dbSNP:756083911
972 972 c, t dbSNP:55953904
985 985 a, g dbSNP:372322441
992 992 a, g dbSNP:748783763
993 993 a, c, g dbSNP:80356719
1003 1003 c, g dbSNP:121908395
1006 1006 a, g dbSNP:140046109
1008 1008 -, agc dbSNP:747244376
1009 1009 c, g dbSNP:376304074
1010 1010 c, t dbSNP:778509754
1015 1015 a, c, g, t dbSNP:80356721
1017 1017 a, c, g dbSNP:80356723
1018 1018 a, g dbSNP:777069592
1026 1026 a, g dbSNP:4884357
1034 1034 a, g dbSNP:146402671
1047 1047 a, g dbSNP:770317817
1061 1061 g, t dbSNP:193107117
1064 1064 a, g dbSNP:552576600
1065 1065 a, g dbSNP:80356725
1075 1075 c, g dbSNP:150052883
1077 1077 a, g dbSNP:80356726
1079 1079 a, g dbSNP:145364830
1091 1091 c, t dbSNP:774665350
1092 1092 c, t dbSNP:377713993
1093 1093 c, t dbSNP:267597911
1097 1097 c, t dbSNP:547979470
1098 1098 a, g dbSNP:373538082
1101 1101 a, g dbSNP:750230325
1106 1106 c, t dbSNP:755921841
1109 1109 c, t dbSNP:777072801
1125 1125 a, c dbSNP:80356727
1129 1129 a, g dbSNP:80356728
1138 1138 a, g dbSNP:80356729
1143 1143 a, g dbSNP:80356730
1157 1157 c, t dbSNP:753813187
1162 1162 a, g dbSNP:80356731
1168 1168 a, g dbSNP:754449452
1169 1169 a, c dbSNP:80356732
1174 1174 c, t dbSNP:778421436
1175 1175 a, g dbSNP:571100031
1176 1176 g, t dbSNP:80356733
1184 1184 a, c, g dbSNP:528494087
1189 1189 a, g dbSNP:80356734
1190 1190 c, t dbSNP:561479675
1205 1205 c, t dbSNP:770092269
1210 1210 c, t dbSNP:776096623
1217 1217 g, t dbSNP:80356735
1231 1231 c, g dbSNP:80356736
1232 1232 c, g, t dbSNP:148325203
1235 1235 c, t dbSNP:377531374
1236 1236 a, g dbSNP:755393183
1238 1238 c, t dbSNP:767767431
1244 1244 a, c dbSNP:773355720
1255 1255 -, a dbSNP:80356737
1256 1256 c, t dbSNP:147795017
1257 1257 a, g dbSNP:766196255
1261 1261 c, g dbSNP:753730998
1269 1269 c, t dbSNP:80356738
1270 1270 c, g dbSNP:80356739
1278 1278 a, c, g dbSNP:367543041
1281 1281 a, g dbSNP:80356740
1302 1302 a, g dbSNP:80356741
1303 1303 a, g dbSNP:80356742
1308 1308 a, g dbSNP:757893581
1312 1312 c, t dbSNP:80356743
1313 1313 a, g dbSNP:543149287
1314 1314 a, g dbSNP:756451309
1316 1316 c, t dbSNP:780579499
1347 1347 a, g dbSNP:762209110
1382 1382 -, gt dbSNP:770985747
1391 1391 -, t dbSNP:776662743
1405 1405 c, t dbSNP:749743510
1416 1416 c, g dbSNP:769281218
1421 1421 c, t dbSNP:779622218
1423 1423 a, g dbSNP:373319524
1452 1452 c, g dbSNP:185638796
1462 1462 c, t dbSNP:80356744
1477 1477 g, t dbSNP:550403167
1493 1493 g, t dbSNP:568944641
1563 1563 a, g dbSNP:780670219
1587 1587 a, g dbSNP:148414479
1593 1593 c, t dbSNP:557787340
1616 1616 c, t dbSNP:573267417
1649 1649 c, t dbSNP:573058752
1721 1721 c, t dbSNP:533778494
1722 1722 a, g dbSNP:555353123
1747 1747 c, g dbSNP:548888176
1764 1764 a, g dbSNP:755772086
1804 1804 a, c dbSNP:573824736
1819 1819 a, c dbSNP:777323104
1842 1842 -, tttt dbSNP:755733628
1868 1868 -, g dbSNP:763044830
1881 1881 a, g dbSNP:544313146
1893 1893 c, t dbSNP:563939085
1897 1897 a, g dbSNP:760833870
1903 1903 a, g dbSNP:770659882
1921 1921 a, g dbSNP:766709042
1930 1930 c, g dbSNP:750948407
1935 1935 a, g dbSNP:776417983
1956 1956 c, t dbSNP:1064824
1961 1961 -, agt dbSNP:759521197
1970 1970 a, g dbSNP:759396520
1984 1984 a, t dbSNP:575772488
1998 1998 c, t dbSNP:752614150
1999 1999 a, g dbSNP:748863467
2000 2000 c, t dbSNP:374735544
2010 2010 c, t dbSNP:751165380
2027 2027 c, t dbSNP:546346594
2044 2044 c, t dbSNP:770786699
2045 2045 a, g dbSNP:778834503
2049 2049 c, t dbSNP:745611651
2076 2076 a, g dbSNP:387906334
2099 2099 a, g dbSNP:564637529
2130 2130 c, t dbSNP:528715466
2282 2282 c, t dbSNP:181715581
2342 2342 c, t dbSNP:751628760
2386 2386 a, c dbSNP:7545171
2387 2387 g, t dbSNP:141412238
2390 2390 a, t dbSNP:7514132
2398 2398 -, t dbSNP:529176283
2424 2424 c, g dbSNP:775184230
2425 2425 a, t dbSNP:7511713
2460 2460 c, t dbSNP:184303021
2467 2467 c, g dbSNP:188745732
2521 2521 c, t dbSNP:569304701
2525 2525 a, c dbSNP:767556095
2547 2547 c, t dbSNP:181172753
2606 2606 a, g dbSNP:11093
2882 2882 g, t dbSNP:202125775
2974 2974 -, tttg dbSNP:748047297
2974 2974 c, t dbSNP:769981440
3001 3001 a, t dbSNP:551513393
3002 3002 a, t dbSNP:566657331
3078 3078 a, g dbSNP:534073893
3097 3097 c, g dbSNP:150412704
3122 3122 c, t dbSNP:773363335
3156 3156 c, t dbSNP:573662295
3163 3163 a, g dbSNP:367730821
3195 3195 a, g dbSNP:537965776
3233 3233 a, g dbSNP:185335376
3240 3240 a, g dbSNP:373070606
3252 3252 c, t dbSNP:763142065
3294 3294 c, t dbSNP:188129567
3325 3325 a, c dbSNP:766947093
3359 3359 c, t dbSNP:775031068
3386 3386 c, t dbSNP:760003156
3405 3405 a, g dbSNP:546087173
3427 3427 a, g dbSNP:752628438
3434 3434 a, g dbSNP:564700348
3451 3451 a, g dbSNP:562716883
3455 3455 g, t dbSNP:573241524
3476 3476 c, t dbSNP:540511549
3537 3537 a, t dbSNP:767900931
3550 3550 a, c dbSNP:753061819
3595 3595 c, t dbSNP:756101899
3603 3603 -, t dbSNP:769903956
3618 3618 a, g dbSNP:763189855
3631 3631 a, g dbSNP:552057039
3669 3669 -, gtttt dbSNP:145446787
3671 3671 c, t dbSNP:199558954
3672 3672 -, tgttt dbSNP:5772439
3672 3672 a, t dbSNP:200729007
3673 3673 -, gtttt, tgttt dbSNP:3059695
3710 3710 a, g dbSNP:114897688
3712 3712 c, t dbSNP:138320721
3713 3713 a, g dbSNP:182302907
3732 3732 c, t dbSNP:766754751
3763 3763 g, t dbSNP:753675523
3766 3766 a, g dbSNP:753285584
3794 3794 a, g dbSNP:533417171
3849 3849 c, t dbSNP:756780885
3916 3916 a, c dbSNP:778779399
3953 3953 a, g dbSNP:755828450
4006 4006 a, g dbSNP:565549021
4007 4007 a, c dbSNP:532714006
4039 4039 a, g dbSNP:551331110
4053 4053 g, t dbSNP:370008350
4119 4119 a, g dbSNP:566658679
4129 4129 a, g dbSNP:779882516
4152 4152 a, g dbSNP:187380325
4184 4184 a, t dbSNP:191706916

Target ORF information:

RefSeq Version NM_007375
Organism Homo sapiens (human)
Definition Homo sapiens TAR DNA binding protein (TARDBP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_007375

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGTCTGAAT ATATTCGGGT AACCGAAGAT GAGAACGATG AGCCCATTGA AATACCATCG 
GAAGACGATG GGACGGTGCT GCTCTCCACG GTTACAGCCC AGTTTCCAGG GGCGTGTGGG
CTTCGCTACA GGAATCCAGT GTCTCAGTGT ATGAGAGGTG TCCGGCTGGT AGAAGGAATT
CTGCATGCCC CAGATGCTGG CTGGGGAAAT CTGGTGTATG TTGTCAACTA TCCAAAAGAT
AACAAAAGAA AAATGGATGA GACAGATGCT TCATCAGCAG TGAAAGTGAA AAGAGCAGTC
CAGAAAACAT CCGATTTAAT AGTGTTGGGT CTCCCATGGA AAACAACCGA ACAGGACCTG
AAAGAGTATT TTAGTACCTT TGGAGAAGTT CTTATGGTGC AGGTCAAGAA AGATCTTAAG
ACTGGTCATT CAAAGGGGTT TGGCTTTGTT CGTTTTACGG AATATGAAAC ACAAGTGAAA
GTAATGTCAC AGCGACATAT GATAGATGGA CGATGGTGTG ACTGCAAACT TCCTAATTCT
AAGCAAAGCC AAGATGAGCC TTTGAGAAGC AGAAAAGTGT TTGTGGGGCG CTGTACAGAG
GACATGACTG AGGATGAGCT GCGGGAGTTC TTCTCTCAGT ACGGGGATGT GATGGATGTC
TTCATCCCCA AGCCATTCAG GGCCTTTGCC TTTGTTACAT TTGCAGATGA TCAGATTGCG
CAGTCTCTTT GTGGAGAGGA CTTGATCATT AAAGGAATCA GCGTTCATAT ATCCAATGCC
GAACCTAAGC ACAATAGCAA TAGACAGTTA GAAAGAAGTG GAAGATTTGG TGGTAATCCA
GGTGGCTTTG GGAATCAGGG TGGATTTGGT AATAGCAGAG GGGGTGGAGC TGGTTTGGGA
AACAATCAAG GTAGTAATAT GGGTGGTGGG ATGAACTTTG GTGCGTTCAG CATTAATCCA
GCCATGATGG CTGCCGCCCA GGCAGCACTA CAGAGCAGTT GGGGTATGAT GGGCATGTTA
GCCAGCCAGC AGAACCAGTC AGGCCCATCG GGTAATAACC AAAACCAAGG CAACATGCAG
AGGGAGCCAA ACCAGGCCTT CGGTTCTGGA AATAACTCTT ATAGTGGCTC TAATTCTGGT
GCAGCAATTG GTTGGGGATC AGCATCCAAT GCAGGGTCGG GCAGTGGTTT TAATGGAGGC
TTTGGCTCAA GCATGGATTC TAAGTCTTCT GGCTGGGGAA TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.