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TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [Homo sapiens (human)]

Gene Symbol TNFRSF13B
Entrez Gene ID 23495
Full Name tumor necrosis factor receptor superfamily, member 13B
Synonyms CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 13B
Names
tumor necrosis factor receptor superfamily member 13B
tumor necrosis factor receptor 13B
transmembrane activator and CAML interactor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p11.2

Summary The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604907

Disorder Html: Immunoglobulin A deficiency 2, 609529 (3); Immunodeficiency, common
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu19409 NM_012452 Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu19409D
Sequence Information ORF Nucleotide Sequence (Length: 882bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product tumor necrosis factor receptor superfamily member 13B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF023614.1. This sequence is a reference standard in the RefSeqGene project. On Sep 20, 2002 this sequence version replaced gi:6912693. Summary: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF023614.1, AK313302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCATT AA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_036584.1
CDS14..895
Misc Feature(1)8..10(+)
Misc Feature(2)113..748(+)
Misc Feature(3)113..271(+)
Misc Feature(4)113..211(+)
Misc Feature(5)224..325(+)
Misc Feature(6)278..523(+)
Misc Feature(7)509..571(+)
Misc Feature(8)512..571(+)
Misc Feature(9)527..703(+)
Exon (1)1..74
Gene:TNFRSF13B
Gene Synonym:
Exon (2)75..212
Gene:TNFRSF13B
Gene Synonym:
Exon (3)213..458
Gene:TNFRSF13B
Gene Synonym:
Exon (4)459..644
Gene:TNFRSF13B
Gene Synonym:
Exon (5)645..1358
Gene:TNFRSF13B
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:774050898
8 8 c, t dbSNP:766017850
16 16 a, g, t dbSNP:772864862
17 17 a, g dbSNP:769586971
19 19 c, t dbSNP:748036053
21 21 a, g dbSNP:201599964
29 29 c, t dbSNP:768911609
30 30 a, g dbSNP:747078163
34 34 c, g dbSNP:780461208
39 39 a, g dbSNP:772399974
42 42 a, g dbSNP:746052120
43 43 c, t dbSNP:779176755
47 47 c, t dbSNP:779924436
48 48 a, g dbSNP:754315707
51 51 a, g dbSNP:778241634
52 52 c, t dbSNP:754552134
53 53 c, g, t dbSNP:370503383
54 54 a, g, t dbSNP:200309474
62 62 c, g dbSNP:764951604
64 64 a, g dbSNP:761651931
71 71 c, t dbSNP:200013015
72 72 a, g dbSNP:768682333
83 83 a, g dbSNP:774505373
87 87 c, t dbSNP:534147180
88 88 a, g dbSNP:749666239
88 88 -, g dbSNP:763698599
89 89 c, t dbSNP:773591883
93 93 c, g dbSNP:770108193
94 94 a, g dbSNP:8072293
97 97 -, gg dbSNP:756097074
104 104 a, g dbSNP:368391092
105 105 a, t dbSNP:757910034
106 106 c, g dbSNP:745349768
114 114 g, t dbSNP:778477333
115 115 c, t dbSNP:756955033
116 116 a, c dbSNP:753500225
117 117 -, ccg dbSNP:752738448
118 118 c, t dbSNP:200868537
119 119 a, g dbSNP:143099385
122 122 c, g dbSNP:752740455
125 125 c, t dbSNP:147891155
131 131 c, t dbSNP:72553874
133 133 a, g dbSNP:759576194
134 134 a, c, g dbSNP:67951770
134 134 -, g dbSNP:67951769
135 135 a, g dbSNP:763197017
137 137 a, c dbSNP:531640813
138 138 a, c dbSNP:770198071
139 139 c, t dbSNP:377551435
145 145 a, g dbSNP:200936104
147 147 c, g dbSNP:777041889
152 152 -, t dbSNP:767415456
152 152 a, t dbSNP:769182186
158 158 c, t dbSNP:374547688
161 161 g, t dbSNP:778514858
178 178 c, t dbSNP:756655390
184 184 c, g dbSNP:149084717
191 191 c, t dbSNP:777555444
192 192 a, g dbSNP:373134429
195 195 c, t dbSNP:752511316
196 196 c, t dbSNP:767410234
204 204 c, g dbSNP:145002378
210 210 c, g dbSNP:751382736
211 211 a, c dbSNP:144718007
217 217 -, a dbSNP:72553875
217 217 a, g dbSNP:758543420
218 218 c, t dbSNP:562284274
220 220 c, t dbSNP:765245909
227 227 c, t dbSNP:375514495
228 228 a, g dbSNP:55916807
231 231 -, g dbSNP:34182967
233 233 a, g dbSNP:764542734
239 239 a, g, t dbSNP:146436713
240 240 a, g dbSNP:772701872
244 244 a, g dbSNP:371317735
249 249 a, g dbSNP:72553876
252 252 a, g dbSNP:546335485
254 254 a, c dbSNP:769360883
264 264 c, g dbSNP:747863360
266 266 a, g dbSNP:780655897
273 273 a, t dbSNP:72553877
276 276 a, g dbSNP:759002769
279 279 a, g dbSNP:746779126
282 282 c, t dbSNP:780026926
288 288 a, t dbSNP:368250378
293 293 a, g dbSNP:200612226
296 296 c, g dbSNP:549493928
301 301 a, c dbSNP:778997868
302 302 c, t dbSNP:757279559
303 303 c, g dbSNP:754139414
304 304 g, t dbSNP:35062843
310 310 -, t dbSNP:72553878
311 311 -, t dbSNP:774205573
312 312 a, g dbSNP:75885572
316 316 a, t dbSNP:752990010
317 317 a, t dbSNP:767933010
318 318 a, g dbSNP:760123037
319 319 a, c dbSNP:774955611
319 319 -, c dbSNP:766460129
321 321 c, t dbSNP:764858993
323 323 c, t dbSNP:34557412
324 324 a, g dbSNP:72553879
326 326 a, g dbSNP:768185098
340 340 c, g dbSNP:746618447
342 342 a, g, t dbSNP:150848825
345 345 c, g dbSNP:745828792
348 348 c, t dbSNP:778801696
359 359 a, c dbSNP:757399024
367 367 c, g dbSNP:749323840
370 370 a, c, g dbSNP:374322117
374 374 c, t dbSNP:752897955
376 376 c, g dbSNP:759551631
377 377 c, t dbSNP:201124889
378 378 a, g dbSNP:755343222
379 379 g, t dbSNP:752157746
397 397 c, t dbSNP:766957464
411 411 c, t dbSNP:761449168
412 412 a, g dbSNP:371292644
414 414 c, g dbSNP:776020692
423 423 a, c dbSNP:763594708
425 425 c, g dbSNP:760278879
428 428 c, t dbSNP:141494621
431 431 a, g dbSNP:199578237
440 440 a, g dbSNP:745632182
444 444 a, c, g, t dbSNP:104894650
446 446 a, g dbSNP:766625705
450 450 c, t dbSNP:777717920
456 456 c, t dbSNP:200173159
457 457 a, t dbSNP:748400544
458 458 a, g dbSNP:72553880
465 465 c, t dbSNP:200037919
466 466 a, g dbSNP:768819413
468 468 a, g dbSNP:72553881
469 469 -, g dbSNP:763264571
469 469 a, g dbSNP:775743817
473 473 a, t dbSNP:747259900
474 474 a, g dbSNP:780302506
480 480 a, g dbSNP:772365135
481 481 g, t dbSNP:148758686
482 482 a, g dbSNP:765485513
493 493 a, g dbSNP:779346761
505 505 a, c, g dbSNP:72553882
507 507 a, g dbSNP:550077773
520 520 -, ctc dbSNP:773146479
525 525 g, t dbSNP:143027621
526 526 a, g dbSNP:754435124
528 528 a, g dbSNP:751216929
530 530 a, g dbSNP:369937497
532 532 c, t dbSNP:151139237
533 533 a, g, t dbSNP:375396272
542 542 c, t dbSNP:761877520
544 544 c, t dbSNP:34088818
545 545 c, t dbSNP:764319738
548 548 c, t dbSNP:145912877
555 555 a, c, t dbSNP:72553883
556 556 a, g dbSNP:746018705
558 558 g, t dbSNP:774782734
562 562 c, t dbSNP:527347712
566 566 c, t dbSNP:749816465
567 567 g, t dbSNP:778227535
574 574 a, g dbSNP:373469090
576 576 -, aga dbSNP:376630110
576 576 a, t dbSNP:74811083
579 579 g, t dbSNP:199777698
580 580 a, g, t dbSNP:370856157
581 581 a, c, g dbSNP:150101848
583 583 a, g dbSNP:199810075
584 584 -, g dbSNP:72553884
584 584 c, g dbSNP:753867822
584 584 -, g dbSNP:748653062
585 585 -, a dbSNP:769165409
590 590 c, t dbSNP:764125338
592 592 a, c, g, t dbSNP:72553885
594 594 aa, cc, gg dbSNP:121908379
594 594 a, c dbSNP:544455005
595 595 a, c dbSNP:575942461
597 597 g, t dbSNP:771332658
601 601 g, t dbSNP:56248318
603 603 c, g dbSNP:749618227
604 604 c, g dbSNP:773773424
605 605 c, t dbSNP:140781824
606 606 a, g dbSNP:150974807
613 613 a, g dbSNP:371989142
617 617 c, t dbSNP:143562358
618 618 a, g dbSNP:104894649
627 627 c, t dbSNP:201068309
628 628 a, g dbSNP:778680726
631 631 c, t dbSNP:147846226
643 643 a, g dbSNP:753672916
646 646 c, t dbSNP:199592890
649 649 c, g, t dbSNP:755149539
650 650 a, g, t dbSNP:140914723
651 651 c, t dbSNP:763164041
652 652 a, g dbSNP:750598581
653 653 a, g dbSNP:765685046
654 654 c, t dbSNP:144560464
661 661 -, c dbSNP:756827159
661 661 c, t dbSNP:777265646
662 662 c, g dbSNP:567602037
671 671 a, g dbSNP:769031395
672 672 c, t dbSNP:56063729
676 676 c, t dbSNP:533796529
677 677 a, g dbSNP:770524541
683 683 c, g dbSNP:748968841
685 685 c, g, t dbSNP:769670646
686 686 a, g dbSNP:368290908
696 696 a, c dbSNP:201886192
700 700 a, c dbSNP:781245217
701 701 g, t dbSNP:754919920
703 703 c, t dbSNP:746878754
706 706 c, g dbSNP:145711865
715 715 c, t dbSNP:758453350
717 717 -, ct dbSNP:749017984
717 717 c, t dbSNP:750688254
718 718 c, t dbSNP:765377299
719 719 g, t dbSNP:201021960
729 729 c, t dbSNP:375891337
730 730 a, g dbSNP:199603343
735 735 c, t dbSNP:370250196
736 736 a, g, t dbSNP:766034334
740 740 -, g dbSNP:777407071
745 745 c, t dbSNP:371893711
746 746 a, g dbSNP:372816963
749 749 g, t dbSNP:72553886
753 753 c, t dbSNP:149635611
754 754 a, c, g dbSNP:776292713
764 764 c, t dbSNP:568535162
765 765 c, t dbSNP:34562254
766 766 -, c dbSNP:755752100
766 766 c, t dbSNP:367583089
767 767 a, g dbSNP:111439115
771 771 c, g dbSNP:191731200
777 777 a, g dbSNP:758545106
781 781 g, t dbSNP:745925364
784 784 a, c dbSNP:778994795
787 787 a, g dbSNP:757425278
789 789 a, g, t dbSNP:764387835
792 792 a, g dbSNP:150660451
798 798 a, g dbSNP:753296393
800 800 a, g dbSNP:768133177
810 810 c, t dbSNP:752825527
826 826 c, t dbSNP:200924433
836 836 c, t dbSNP:540918755
837 837 c, t dbSNP:761400653
841 841 c, g dbSNP:144383122
844 844 c, t dbSNP:11078355
851 851 c, g dbSNP:374957601
854 854 a, g dbSNP:201451843
857 857 a, g dbSNP:772011245
877 877 g, t dbSNP:745751910
879 879 g, t dbSNP:778892365
881 881 a, c, g dbSNP:575778769
882 882 -, g dbSNP:767501038
882 882 -, g dbSNP:752255870
882 882 g, t dbSNP:778108471
884 884 c, t dbSNP:146392507
886 886 a, g dbSNP:370631317
897 897 c, t dbSNP:142248746
900 900 a, g dbSNP:755440988
906 906 c, g dbSNP:752062952
916 916 a, g dbSNP:764673520
920 920 a, g dbSNP:761359165
928 928 -, gaga dbSNP:754963471
928 928 a, g dbSNP:573273447
932 932 c, t dbSNP:188626884
936 936 a, g dbSNP:369550819
938 938 g, t dbSNP:377155942
941 941 a, g dbSNP:775269337
969 969 -, gggagag dbSNP:557897179
980 980 -, atg dbSNP:374314027
981 981 -, tga dbSNP:150068036
981 981 g, t dbSNP:534582608
984 984 -, a dbSNP:548624436
985 985 -, gag dbSNP:199572305
989 989 c, g dbSNP:571356374
993 993 -, g dbSNP:555681458
1027 1027 a, g dbSNP:183446665
1049 1049 g, t dbSNP:537564904
1068 1068 a, g dbSNP:56153623
1085 1085 a, g dbSNP:548644843
1089 1089 a, g dbSNP:535124800
1095 1095 c, g dbSNP:373632897
1101 1101 a, g dbSNP:566453119
1104 1104 a, t dbSNP:761541635
1121 1121 a, g dbSNP:546986339
1137 1137 a, g dbSNP:533625775
1170 1170 a, g dbSNP:564544575
1171 1171 c, g dbSNP:551158631
1189 1189 c, g dbSNP:531106002
1212 1212 c, t dbSNP:768522584
1244 1244 c, t dbSNP:562213676
1248 1248 a, c dbSNP:56059714
1284 1284 c, t dbSNP:71362290
1287 1287 a, g dbSNP:190709636
1309 1309 a, g dbSNP:55701306

Target ORF information:

RefSeq Version NM_012452
Organism Homo sapiens (human)
Definition Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_012452

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCATT AA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.