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TNFRSF13B cDNA ORF clone, Homo sapiens (human)

Gene Symbol TNFRSF13B
Entrez Gene ID 23495
Full Name tumor necrosis factor receptor superfamily, member 13B
Synonyms CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 13B
Names
tumor necrosis factor receptor superfamily member 13B
tumor necrosis factor receptor 13B
transmembrane activator and CAML interactor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p11.2

Summary The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604907

Disorder Html: Immunoglobulin A deficiency 2, 609529 (3); Immunodeficiency, common

mRNA and Protein(s)

mRNA Protein Name
NM_012452 NP_036584 tumor necrosis factor receptor superfamily member 13B



Homo sapiens (human) TNFRSF13B NP_036584.1
Pan troglodytes (chimpanzee) TNFRSF13B XP_001161361.2
Macaca mulatta (Rhesus monkey) TNFRSF13B XP_001088700.2
Canis lupus familiaris (dog) TNFRSF13B XP_005620235.1
Mus musculus (house mouse) Tnfrsf13b NP_067324.1
Gallus gallus (chicken) TNFRSF13B NP_001091006.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TNFRSF13B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF13B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19409
NM_012452 Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19409
Clone ID Related Accession (Same CDS sequence) NM_012452
Accession Version NM_012452.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 882bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product tumor necrosis factor receptor superfamily member 13B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF023614.1. This sequence is a reference standard in the RefSeqGene project. On Sep 20, 2002 this sequence version replaced gi:6912693. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF023614.1, AK313302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036584.1
CDS14..895
Misc Feature(1)8..10(+)
Misc Feature(2)113..748(+)
Misc Feature(3)113..271(+)
Misc Feature(4)113..211(+)
Misc Feature(5)224..325(+)
Misc Feature(6)278..523(+)
Misc Feature(7)509..571(+)
Misc Feature(8)512..571(+)
Misc Feature(9)527..703(+)
Exon (1)1..74
Gene:TNFRSF13B
Gene Synonym:
Exon (2)75..212
Gene:TNFRSF13B
Gene Synonym:
Exon (3)213..458
Gene:TNFRSF13B
Gene Synonym:
Exon (4)459..644
Gene:TNFRSF13B
Gene Synonym:
Exon (5)645..1358
Gene:TNFRSF13B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_012452
Organism Homo sapiens (human)
Definition Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012452

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genome-wide association study of lung function phenotypes in a founder population
J. Allergy Clin. Immunol. 133 (1), 248-255 (2014)
Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE, Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM, Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL, Abney M and Ober C.


book

BAFF, APRIL, TWEAK, BCMA, TACI and Fn14 proteins are related to human glioma tumor grade: immunohistochemistry and public microarray data meta-analysis
PLoS ONE 8 (12), E83250 (2013)
Pelekanou V, Notas G, Kampa M, Tsentelierou E, Stathopoulos EN, Tsapis A and Castanas E.


book

CVID-associated TACI mutations affect autoreactive B cell selection and activation
J. Clin. Invest. 123 (10), 4283-4293 (2013)
Romberg,N., Chamberlain,N., Saadoun,D., Gentile,M., Kinnunen,T., Ng,Y.S., Virdee,M., Menard,L., Cantaert,T., Morbach,H., Rachid,R., Martinez-Pomar,N., Matamoros,N., Geha,R., Grimbacher,B., Cerutti,A., Cunningham-Rundles,C. and Meffre,E.


book

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
Nat. Genet. 45 (10), 1221-1225 (2013)
Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, Forsti A, Vijayakrishnan J, Migliorini G, Dobbins SE, Holroyd A, Hose D, Walker BA, Davies FE, Gregory WA, Jackson GH, Irving JA, Pratt G, Fegan C, Fenton JA, Neben K, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Ross FM, Straka C, Einsele H, Langer C, Dorner E, Allan JM, Jauch A, Morgan GJ, Hemminki K, Houlston RS and Goldschmidt H.


book

Heterozygous alterations of TNFRSF13B/TACI in tonsillar hypertrophy and sarcoidosis
Clin. Dev. Immunol. 2013, 532437 (2013)
Speletas M, Salzer U, Florou Z, Petinaki E, Daniil Z, Bardaka F, Gourgoulianis KI, Skoulakis C and Germenis AE.


book

TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation
J. Exp. Med. 192 (1), 137-143 (2000)
Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ and Hsu H.


book

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
Nat. Immunol. 1 (1), 37-41 (2000)
Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A and Dixit VM.


book

Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
Curr. Biol. 10 (13), 785-788 (2000)
Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM and Ashkenazi A.


book

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Nature 404 (6781), 995-999 (2000)
Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W and Clegg CH.


book

NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily
Science 278 (5335), 138-141 (1997)
von Bulow GU and Bram RJ.


 
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