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PTF1A cDNA ORF clone, Homo sapiens (human)

Gene Symbol PTF1A
Entrez Gene ID 256297
Full Name pancreas specific transcription factor, 1a
Synonyms PACA, PAGEN2, PTF1-p48, bHLHa29
General protein information
Preferred Names
pancreas transcription factor 1 subunit alpha
Names
pancreas transcription factor 1 subunit alpha
class II bHLH protein PTF1A
bHLH transcription factor p48
class A basic helix-loop-helix protein 29
pancreas-specific transcription factor 1a
exocrine pancreas-specific transcription factor p48
p48 DNA-binding subunit of transcription factor PTF1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10p12.2

Summary This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607194

Disorder Html: Diabetes mellitus, permanent neonatal, with cerebellar agenesis,





The following PTF1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTF1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19480 NM_178161 Homo sapiens pancreas specific transcription factor, 1a (PTF1A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.30
$309.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19480
Accession Version NM_178161.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 987bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pancreas transcription factor 1 subunit alpha
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139281.7, BM055347.1 and CK904916.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2006 this sequence version replaced gi:30039709. Summary: This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK904917.1, BM055347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGACGCGG TGTTGCTGGA GCACTTCCCC GGGGGCCTAG ACGCCTTTCC TTCTTCGTAC 
TTCGACGAGG ACGACTTCTT CACCGACCAG TCTTCACGGG ACCCCCTGGA GGACGGCGAT
GAGCTGCTGG CGGACGAGCA GGCCGAGGTG GAGTTCCTTA GCCACCAGCT CCACGAGTAC
TGCTACCGCG ACGGGGCGTG CCTGCTGCTG CAGCCCGCGC CCCCGGCCGC CCCGCTAGCG
CTCGCCCCGC CGTCCTCGGG GGGCCTCGGT GAGCCAGACG ACGGCGGCGG CGGCGGCTAC
TGCTGCGAGA CGGGGGCGCC CCCAGGCGGC TTCCCCTACT CGCCCGGCTC GCCGCCCTCG
TGCCTGGCCT ACCCGTGCGC CGGGGCGGCA GTACTGTCTC CCGGGGCGCG GCTGCGCGGC
CTGAGCGGAG CGGCGGCTGC GGCGGCGCGG CGCCGGCGGC GGGTGCGCTC CGAGGCGGAG
CTGCAGCAGC TGCGGCAGGC GGCCAACGTG CGCGAGCGGC GGCGCATGCA GTCCATCAAC
GACGCCTTCG AGGGGCTGCG CTCGCACATC CCCACGCTGC CCTACGAGAA GCGCCTCTCC
AAGGTGGACA CGCTGCGCCT GGCCATCGGC TACATCAACT TCCTCAGCGA GCTCGTGCAG
GCCGACCTGC CCTTGCGCGG CGGTGGCGCG GGCGGCTGCG GGGGGCCGGG CGGCGGCGGG
CGCCTGGGCG GGGACAGCCC GGGCAGCCAG GCCCAGAAGG TCATCATCTG CCATCGGGGC
ACCCGGTCCC CCTCCCCCAG CGACCCTGAT TATGGCCTCC CTCCCCTAGC AGGACACTCT
CTCTCATGGA CTGATGAAAA ACAACTCAAG GAACAAAATA TTATCCGAAC AGCCAAAGTC
TGGACCCCAG AGGACCCCAG AAAACTCAAC AGCAAATCTT CCTTCAACAA CATAGAAAAC
GAACCACCAT TTGAGTTTGT GTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_835455.1
CDS1..987
Misc Feature(1)493..660(+)
Misc Feature(2)493..603(+)
Misc Feature(3)514..516(+)
Misc Feature(4)532..657(+)
Exon (1)1..784
Gene:PTF1A
Gene Synonym:
Exon (2)785..1333
Gene:PTF1A
Gene Synonym:
Translation
Position Chain Variation Link
8 8 a, c, t dbSNP:146089816
22 22 c, t dbSNP:200273790
24 24 c, t dbSNP:777357990
25 25 c, t dbSNP:748809481
27 27 a, c dbSNP:756855059
31 31 a, c, g dbSNP:778414050
36 36 c, t dbSNP:771729592
37 37 c, t dbSNP:775289761
42 42 c, t dbSNP:746895042
44 44 c, t dbSNP:140097468
45 45 c, t dbSNP:776619828
53 53 c, t dbSNP:761787095
66 66 c, t dbSNP:765408777
67 67 a, g dbSNP:773275837
75 75 a, c dbSNP:376887768
81 81 c, t dbSNP:766603590
85 85 g, t dbSNP:371045580
93 93 g, t dbSNP:755476080
102 102 c, g, t dbSNP:199831799
103 103 a, c dbSNP:756696260
105 105 a, c dbSNP:778522883
107 107 -, t dbSNP:773789588
126 126 a, g dbSNP:141937982
127 127 c, t dbSNP:758086305
128 128 c, t dbSNP:779760779
132 132 g, t dbSNP:746806973
133 133 g, t dbSNP:201397561
136 136 a, g, t dbSNP:776528075
142 142 a, g dbSNP:144291757
143 143 a, c dbSNP:144692521
161 161 a, g dbSNP:773366109
162 162 c, t dbSNP:117678424
164 164 a, g dbSNP:79353984
165 165 c, g dbSNP:199556852
172 172 c, t dbSNP:759962056
175 175 a, g dbSNP:377294323
183 183 c, t dbSNP:768039206
186 186 c, g, t dbSNP:142955321
187 187 c, t dbSNP:761273405
190 190 a, g dbSNP:375826548
192 192 c, t dbSNP:749956400
194 194 c, g dbSNP:757918082
198 198 a, g dbSNP:370434971
201 201 c, t dbSNP:539214102
204 204 c, g dbSNP:754736562
210 210 -, gcagccc dbSNP:760612254
229 229 a, g dbSNP:549685905
233 233 c, g dbSNP:747988912
251 251 c, t dbSNP:769782380
262 262 c, g dbSNP:777646329
263 263 a, g dbSNP:569569636
269 269 c, g dbSNP:535090775
282 282 -, cgg dbSNP:766485502
386 386 c, t dbSNP:370163562
426 426 c, t dbSNP:759873796
499 499 a, g dbSNP:565666569
556 556 c, t dbSNP:373179034
566 566 a, g dbSNP:775942375
567 567 c, t dbSNP:761024448
570 570 c, t dbSNP:764659673
594 594 c, t dbSNP:534448485
613 613 c, t dbSNP:762432245
633 633 a, c dbSNP:564663588
634 634 a, g dbSNP:765915324
638 638 a, g dbSNP:751173160
643 643 c, t dbSNP:754650282
649 649 a, g dbSNP:780794545
666 666 a, c dbSNP:752539260
691 691 c, g dbSNP:557817472
705 705 g, t dbSNP:755927793
712 712 g, t dbSNP:777751456
722 722 c, g dbSNP:749229626
731 731 c, g dbSNP:771099187
746 746 a, g dbSNP:779163060
751 751 g, t dbSNP:746034742
753 753 c, t dbSNP:765145875
757 757 a, g dbSNP:772430755
760 760 a, g dbSNP:775644284
779 779 a, g dbSNP:761091661
780 780 c, t dbSNP:768953977
783 783 a, c dbSNP:777165591
784 784 a, c dbSNP:762338607
786 786 a, g dbSNP:199715779
787 787 a, c, t dbSNP:7918487
787 787 -, t dbSNP:112225630
796 796 c, t dbSNP:780304799
801 801 a, c dbSNP:747239057
802 802 a, g dbSNP:139882221
808 808 c, g dbSNP:776882560
814 814 a, g dbSNP:748599490
816 816 c, t dbSNP:770292027
828 828 a, c dbSNP:773773722
836 836 a, g dbSNP:200834445
837 837 c, g dbSNP:759032576
839 839 c, g dbSNP:766985048
841 841 c, t dbSNP:775173319
843 843 a, c dbSNP:760272788
846 846 a, g dbSNP:763898018
850 850 a, g dbSNP:753695624
851 851 a, c dbSNP:144865627
867 867 c, g dbSNP:549237556
878 878 a, c dbSNP:368083211
879 879 -, tat dbSNP:753932403
886 886 c, t dbSNP:104894186
890 890 c, g dbSNP:374698627
938 938 c, t dbSNP:758477259
940 940 a, t dbSNP:45569235
941 941 c, t dbSNP:747205728
942 942 c, t dbSNP:755171117
947 947 a, g dbSNP:781469928
960 960 a, c, t dbSNP:181911810
964 964 c, t dbSNP:779348995
969 969 a, g, t dbSNP:147793897
975 975 a, g dbSNP:771566660
995 995 c, t dbSNP:774881490
998 998 a, g dbSNP:760314781
1002 1002 a, g dbSNP:10828415
1006 1006 c, g dbSNP:776486186
1010 1010 a, t dbSNP:761681370
1017 1017 c, t dbSNP:765167737
1025 1025 a, t dbSNP:140894413
1036 1036 c, t dbSNP:368126939
1037 1037 a, g dbSNP:557636410
1039 1039 a, g dbSNP:766424499
1095 1095 c, t dbSNP:551136108
1110 1110 -, tatc dbSNP:533517653
1132 1132 a, g dbSNP:574264522
1144 1144 -, gat dbSNP:149560393
1177 1177 c, t dbSNP:74121767
1220 1220 c, t dbSNP:780591716
1225 1225 c, g dbSNP:553599033
1235 1235 c, t dbSNP:573178489
1246 1246 c, g dbSNP:144824953
1251 1251 c, t dbSNP:747435226
1257 1257 a, c dbSNP:565048939
1266 1266 g, t dbSNP:569371211
1293 1293 c, g dbSNP:769212869
1315 1315 a, g dbSNP:754238531

Target ORF information:

RefSeq Version NM_178161
Organism Homo sapiens (human)
Definition Homo sapiens pancreas specific transcription factor, 1a (PTF1A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_178161

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGACGCGG TGTTGCTGGA GCACTTCCCC GGGGGCCTAG ACGCCTTTCC TTCTTCGTAC 
TTCGACGAGG ACGACTTCTT CACCGACCAG TCTTCACGGG ACCCCCTGGA GGACGGCGAT
GAGCTGCTGG CGGACGAGCA GGCCGAGGTG GAGTTCCTTA GCCACCAGCT CCACGAGTAC
TGCTACCGCG ACGGGGCGTG CCTGCTGCTG CAGCCCGCGC CCCCGGCCGC CCCGCTAGCG
CTCGCCCCGC CGTCCTCGGG GGGCCTCGGT GAGCCAGACG ACGGCGGCGG CGGCGGCTAC
TGCTGCGAGA CGGGGGCGCC CCCAGGCGGC TTCCCCTACT CGCCCGGCTC GCCGCCCTCG
TGCCTGGCCT ACCCGTGCGC CGGGGCGGCA GTACTGTCTC CCGGGGCGCG GCTGCGCGGC
CTGAGCGGAG CGGCGGCTGC GGCGGCGCGG CGCCGGCGGC GGGTGCGCTC CGAGGCGGAG
CTGCAGCAGC TGCGGCAGGC GGCCAACGTG CGCGAGCGGC GGCGCATGCA GTCCATCAAC
GACGCCTTCG AGGGGCTGCG CTCGCACATC CCCACGCTGC CCTACGAGAA GCGCCTCTCC
AAGGTGGACA CGCTGCGCCT GGCCATCGGC TACATCAACT TCCTCAGCGA GCTCGTGCAG
GCCGACCTGC CCTTGCGCGG CGGTGGCGCG GGCGGCTGCG GGGGGCCGGG CGGCGGCGGG
CGCCTGGGCG GGGACAGCCC GGGCAGCCAG GCCCAGAAGG TCATCATCTG CCATCGGGGC
ACCCGGTCCC CCTCCCCCAG CGACCCTGAT TATGGCCTCC CTCCCCTAGC AGGACACTCT
CTCTCATGGA CTGATGAAAA ACAACTCAAG GAACAAAATA TTATCCGAAC AGCCAAAGTC
TGGACCCCAG AGGACCCCAG AAAACTCAAC AGCAAATCTT CCTTCAACAA CATAGAAAAC
GAACCACCAT TTGAGTTTGT GTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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