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GABRG2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GABRG2
Entrez Gene ID 2566
Full Name gamma-aminobutyric acid (GABA) A receptor, gamma 2
Synonyms CAE2, ECA2, GEFSP3
General protein information
Preferred Names
gamma-aminobutyric acid receptor subunit gamma-2
Names
gamma-aminobutyric acid receptor subunit gamma-2
GABA(A) receptor, gamma 2
GABA(A) receptor subunit gamma-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q34

Summary This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

137164

Disorder Html: Epilepsy, generalized, with febrile seizures plus, type 3, 604233

mRNA and Protein(s)

mRNA Protein Name
NM_000816 NP_000807 gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor
NM_198904 NP_944494 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor
NM_198903 NP_944493 gamma-aminobutyric acid receptor subunit gamma-2 isoform 3 precursor



Homo sapiens (human) GABRG2 NP_944493.2
Pan troglodytes (chimpanzee) GABRG2 XP_003311017.2
Macaca mulatta (Rhesus monkey) GABRG2 XP_002804663.1
Canis lupus familiaris (dog) GABRG2 XP_867037.1
Bos taurus (cattle) GABRG2 NP_776970.1
Mus musculus (house mouse) Gabrg2 NP_032099.1
Rattus norvegicus (Norway rat) Gabrg2 NP_899156.1
Gallus gallus (chicken) GABRG2 NP_990676.1
Danio rerio (zebrafish) gabrg2 NP_001243179.1
Xenopus (Silurana) tropicalis (western clawed frog) gabrg2 XP_002941681.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GABRG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GABRG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu17585 NM_000816 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $272.30
$389.00
OHu17503
NM_198904 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu18155
NM_198903 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$214.50-$300.30
$429.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17585
Clone ID Related Accession (Same CDS sequence) NM_000816
Accession Version NM_000816.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1404bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA226729.1, BC074795.2, BC069348.1 and AC091984.3. On May 24, 2008 this sequence version replaced gi:38788134. Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 3. It encodes isoform 2 which is shorter than isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X15376.1, BC069348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTGC CCCTACCATT
GATATCCGCC CAAGATCAGC AACCATTCAA ATGAATAATG CTACACACCT TCAAGAGAGA
GATGAAGAGT ACGGCTATGA GTGTCTGGAC GGCAAGGACT GTGCCAGTTT TTTCTGCTGT
TTTGAAGATT GTCGAACAGG AGCTTGGAGA CATGGGAGGA TACATATCCG CATTGCCAAA
ATGGACTCCT ATGCTCGGAT CTTCTTCCCC ACTGCCTTCT GCCTGTTTAA TCTGGTCTAT
TGGGTCTCCT ACCTCTACCT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000807.2
CDS359..1762
Misc Feature(1)290..292(+)
Misc Feature(2)563..1750(+)
Misc Feature(3)563..1174(+)
Misc Feature(4)1178..1246(+)
Misc Feature(5)1193..1741(+)
Misc Feature(6)1256..1324(+)
Misc Feature(7)1358..1426(+)
Misc Feature(8)1454..1456(+)
Misc Feature(9)1631..1684(+)
Misc Feature(10)1688..1756(+)
Exon (1)1..465
Gene:GABRG2
Gene Synonym:
Exon (2)466..617
Gene:GABRG2
Gene Synonym:
Exon (3)618..685
Gene:GABRG2
Gene Synonym:
Exon (4)686..906
Gene:GABRG2
Gene Synonym:
Exon (5)907..989
Gene:GABRG2
Gene Synonym:
Exon (6)990..1127
Gene:GABRG2
Gene Synonym:
Exon (7)1128..1280
Gene:GABRG2
Gene Synonym:
Exon (8)1281..1486
Gene:GABRG2
Gene Synonym:
Exon (9)1487..3933
Gene:GABRG2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000816
Organism Homo sapiens (human)
Definition Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000816

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTGC CCCTACCATT
GATATCCGCC CAAGATCAGC AACCATTCAA ATGAATAATG CTACACACCT TCAAGAGAGA
GATGAAGAGT ACGGCTATGA GTGTCTGGAC GGCAAGGACT GTGCCAGTTT TTTCTGCTGT
TTTGAAGATT GTCGAACAGG AGCTTGGAGA CATGGGAGGA TACATATCCG CATTGCCAAA
ATGGACTCCT ATGCTCGGAT CTTCTTCCCC ACTGCCTTCT GCCTGTTTAA TCTGGTCTAT
TGGGTCTCCT ACCTCTACCT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17503
Clone ID Related Accession (Same CDS sequence) NM_198904
Accession Version NM_198904.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1428bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA226729.1, BC052926.1, BC059389.1 and AC091984.3. On May 24, 2008 this sequence version replaced gi:38788154. Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 3. It encodes isoform 1 which is shorter than isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059389.1, CD013896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTCT TCTTCGGATG
TTTTCCTTCA AGGCCCCTAC CATTGATATC CGCCCAAGAT CAGCAACCAT TCAAATGAAT
AATGCTACAC ACCTTCAAGA GAGAGATGAA GAGTACGGCT ATGAGTGTCT GGACGGCAAG
GACTGTGCCA GTTTTTTCTG CTGTTTTGAA GATTGTCGAA CAGGAGCTTG GAGACATGGG
AGGATACATA TCCGCATTGC CAAAATGGAC TCCTATGCTC GGATCTTCTT CCCCACTGCC
TTCTGCCTGT TTAATCTGGT CTATTGGGTC TCCTACCTCT ACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_944494.1
CDS359..1786
Misc Feature(1)290..292(+)
Misc Feature(2)563..1774(+)
Misc Feature(3)563..1174(+)
Misc Feature(4)1178..1246(+)
Misc Feature(5)1193..1765(+)
Misc Feature(6)1256..1324(+)
Misc Feature(7)1358..1426(+)
Misc Feature(8)1454..1456(+)
Misc Feature(9)1655..1708(+)
Misc Feature(10)1712..1780(+)
Exon (1)1..465
Gene:GABRG2
Gene Synonym:
Exon (2)466..617
Gene:GABRG2
Gene Synonym:
Exon (3)618..685
Gene:GABRG2
Gene Synonym:
Exon (4)686..906
Gene:GABRG2
Gene Synonym:
Exon (5)907..989
Gene:GABRG2
Gene Synonym:
Exon (6)990..1127
Gene:GABRG2
Gene Synonym:
Exon (7)1128..1280
Gene:GABRG2
Gene Synonym:
Exon (8)1281..1486
Gene:GABRG2
Gene Synonym:
Exon (9)1487..1510
Gene:GABRG2
Gene Synonym:
Exon (10)1511..3957
Gene:GABRG2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_198904
Organism Homo sapiens (human)
Definition Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_198904

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTCT TCTTCGGATG
TTTTCCTTCA AGGCCCCTAC CATTGATATC CGCCCAAGAT CAGCAACCAT TCAAATGAAT
AATGCTACAC ACCTTCAAGA GAGAGATGAA GAGTACGGCT ATGAGTGTCT GGACGGCAAG
GACTGTGCCA GTTTTTTCTG CTGTTTTGAA GATTGTCGAA CAGGAGCTTG GAGACATGGG
AGGATACATA TCCGCATTGC CAAAATGGAC TCCTATGCTC GGATCTTCTT CCCCACTGCC
TTCTGCCTGT TTAATCTGGT CTATTGGGTC TCCTACCTCT ACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18155
Clone ID Related Accession (Same CDS sequence) NM_198903
Accession Version NM_198903.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1548bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gamma-aminobutyric acid receptor subunit gamma-2 isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008611.6, AC091926.4 and AC091984.3. This sequence is a reference standard in the RefSeqGene project. On May 24, 2008 this sequence version replaced gi:38788149. Transcript Variant: This variant (3) encodes the longest isoform (3). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036030.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TGGTCTCGTT CTATTGCCCA GGCTGGAATG
TGCAGTGGTG TGATCTCGGC TCACTACAGC CTTCGCTTCT GGGGCTCAAC TGATCCTCCC
ACCTTGGCCT CCAGAGTAGC TGGGATTTCA GATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTCT TCTTCGGATG
TTTTCCTTCA AGGCCCCTAC CATTGATATC CGCCCAAGAT CAGCAACCAT TCAAATGAAT
AATGCTACAC ACCTTCAAGA GAGAGATGAA GAGTACGGCT ATGAGTGTCT GGACGGCAAG
GACTGTGCCA GTTTTTTCTG CTGTTTTGAA GATTGTCGAA CAGGAGCTTG GAGACATGGG
AGGATACATA TCCGCATTGC CAAAATGGAC TCCTATGCTC GGATCTTCTT CCCCACTGCC
TTCTGCCTGT TTAATCTGGT CTATTGGGTC TCCTACCTCT ACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_944493.2
CDS359..1906
Misc Feature(1)290..292(+)
Misc Feature(2)563..1894(+)
Misc Feature(3)563..1294(+)
Misc Feature(4)1313..1885(+)
Exon (1)1..465
Gene:GABRG2
Gene Synonym:
Exon (2)466..617
Gene:GABRG2
Gene Synonym:
Exon (3)618..685
Gene:GABRG2
Gene Synonym:
Exon (4)686..906
Gene:GABRG2
Gene Synonym:
Exon (5)907..989
Gene:GABRG2
Gene Synonym:
Exon (6)990..1109
Gene:GABRG2
Gene Synonym:
Exon (7)1110..1247
Gene:GABRG2
Gene Synonym:
Exon (8)1248..1400
Gene:GABRG2
Gene Synonym:
Exon (9)1401..1606
Gene:GABRG2
Gene Synonym:
Exon (10)1607..1630
Gene:GABRG2
Gene Synonym:
Exon (11)1631..4077
Gene:GABRG2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_198903
Organism Homo sapiens (human)
Definition Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_198903

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGAGTTCGC CAAATATATG GAGCACAGGA AGCTCAGTCT ACTCGACTCC TGTATTTTCA 
CAGAAAATGA CGGTGTGGAT TCTGCTCCTG CTGTCGCTCT ACCCTGGCTT CACTAGCCAG
AAATCTGATG ATGACTATGA AGATTATGCT TCTAACAAAA CATGGGTCTT GACTCCAAAA
GTTCCTGAGG GTGATGTCAC TGTCATCTTA AACAACCTGC TGGAAGGATA TGACAATAAA
CTTCGGCCTG ATATAGGAGT GAAGCCAACG TTAATTCACA CAGACATGTA TGTGAATAGC
ATTGGTCCAG TGAACGCTAT CAATATGGAA TACACTATTG ATATATTTTT TGCGCAAACG
TGGTATGACA GACGTTTGAA ATTTAACAGC ACCATTAAAG TCCTCCGATT GAACAGCAAC
ATGGTGGGGA AAATCTGGAT TCCAGACACT TTCTTCAGAA ATTCCAAAAA AGCTGATGCA
CACTGGATCA CCACCCCCAA CAGGATGCTG AGAATTTGGA ATGATGGTCG AGTGCTCTAC
ACCCTAAGGT TGACAATTGA TGCTGAGTGC CAATTACAAT TGCACAACTT TCCAATGGAT
GAACACTCCT GCCCCTTGGA GTTCTCCAGT TGGTCTCGTT CTATTGCCCA GGCTGGAATG
TGCAGTGGTG TGATCTCGGC TCACTACAGC CTTCGCTTCT GGGGCTCAAC TGATCCTCCC
ACCTTGGCCT CCAGAGTAGC TGGGATTTCA GATGGCTATC CACGTGAAGA AATTGTTTAT
CAATGGAAGC GAAGTTCTGT TGAAGTGGGC GACACAAGAT CCTGGAGGCT TTATCAATTC
TCATTTGTTG GTCTAAGAAA TACCACCGAA GTAGTGAAGA CAACTTCCGG AGATTATGTG
GTCATGTCTG TCTACTTTGA TCTGAGCAGA AGAATGGGAT ACTTTACCAT CCAGACCTAT
ATCCCCTGCA CACTCATTGT CGTCCTATCC TGGGTGTCTT TCTGGATCAA TAAGGATGCT
GTTCCAGCCA GAACATCTTT AGGTATCACC ACTGTCCTGA CAATGACCAC CCTCAGCACC
ATTGCCCGGA AATCGCTCCC CAAGGTCTCC TATGTCACAG CGATGGATCT CTTTGTATCT
GTTTGTTTCA TCTTTGTCTT CTCTGCTCTG GTGGAGTATG GCACCTTGCA TTATTTTGTC
AGCAACCGGA AACCAAGCAA GGACAAAGAT AAAAAGAAGA AAAACCCTCT TCTTCGGATG
TTTTCCTTCA AGGCCCCTAC CATTGATATC CGCCCAAGAT CAGCAACCAT TCAAATGAAT
AATGCTACAC ACCTTCAAGA GAGAGATGAA GAGTACGGCT ATGAGTGTCT GGACGGCAAG
GACTGTGCCA GTTTTTTCTG CTGTTTTGAA GATTGTCGAA CAGGAGCTTG GAGACATGGG
AGGATACATA TCCGCATTGC CAAAATGGAC TCCTATGCTC GGATCTTCTT CCCCACTGCC
TTCTGCCTGT TTAATCTGGT CTATTGGGTC TCCTACCTCT ACCTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

GABAA receptor alpha and gamma subunits shape synaptic currents via different mechanisms
J. Biol. Chem. 289 (9), 5399-5411 (2014)
Dixon C, Sah P, Lynch JW and Keramidas A.


book

GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures
Pharmacogenet. Genomics 23 (11), 605-610 (2013)
Balan S, Sathyan S, Radha SK, Joseph V, Radhakrishnan K and Banerjee M.


book

Trafficking-deficient mutant GABRG2 subunit amount may modify epilepsy phenotype
Ann. Neurol. 74 (4), 547-559 (2013)
Kang JQ, Shen W and Macdonald RL.


book

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human alpha1beta3gamma2 gamma-aminobutyric acid type A (GABAA) receptor
J. Biol. Chem. 288 (27), 19343-19357 (2013)
Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW and Cohen JB.


book

A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites
PLoS ONE 8 (1), E52323 (2013)
Bergmann R, Kongsbak K, Sorensen PL, Sander T and Balle T.


book

Assignment of genes encoding GABAA receptor subunits alpha 1, alpha 6, beta 2, and gamma 2 to a YAC contig of 5q33
Eur. J. Hum. Genet. 4 (4), 199-204 (1996)
Kostrzewa M, Kohler A, Eppelt K, Hellam L, Fairweather ND, Levy ER, Monaco AP and Muller U.


book

Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform
Genomics 23 (3), 528-533 (1994)
Russek SJ and Farb DH.


book

Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor
J. Biol. Chem. 267 (20), 14470-14476 (1992)
Moss SJ, Doherty CA and Huganir RL.


book

Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome
Proc. Natl. Acad. Sci. U.S.A. 89 (13), 5857-5861 (1992)
Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D and Sikela JM.


book

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
Nature 338 (6216), 582-585 (1989)
Pritchett DB, Sontheimer H, Shivers BD, Ymer S, Kettenmann H, Schofield PR and Seeburg PH.


 
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