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ALX3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ALX3
Entrez Gene ID 257
Full Name ALX homeobox 3
Synonyms FND, FND1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.3

Summary This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606014

Disorder Html: Frontorhiny, 136760 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_006492 NP_006483 homeobox protein aristaless-like 3


Homo sapiens (human) ALX3 NP_006483.2
Pan troglodytes (chimpanzee) ALX3 XP_524801.2
Macaca mulatta (Rhesus monkey) ALX3 XP_001099295.1
Canis lupus familiaris (dog) ALX3 XP_005621859.1
Bos taurus (cattle) ALX3 NP_001179482.1
Mus musculus (house mouse) Alx3 NP_031467.1
Rattus norvegicus (Norway rat) Alx3 NP_001007013.1
Gallus gallus (chicken) ALX3 XP_003642783.2
Danio rerio (zebrafish) LOC566955 XP_005167168.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ALX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19546 NM_006492 Homo sapiens ALX homeobox 3 (ALX3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19546
Clone ID Related Accession (Same CDS sequence) NM_006492
Accession Version NM_006492.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1032bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein aristaless-like 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC113428.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced gi:5729727. ##Evidence-Data-START## Transcript exon combination :: BC113428.1, BC112007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006483.2
CDS89..1120
Misc Feature(1)80..82(+)
Misc Feature(2)548..724(+)
Misc Feature(3)548..718(+)
Misc Feature(4)554..706(+)
Exon (1)1..365
Gene:ALX3
Gene Synonym:
Exon (2)366..682
Gene:ALX3
Gene Synonym:
Exon (3)683..811
Gene:ALX3
Gene Synonym:
Exon (4)812..1478
Gene:ALX3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006492
Organism Homo sapiens (human)
Definition Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006492

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies
Am. J. Med. Genet. A 158A (5), 1233-1235 (2012)
Ribeiro-Bicudo LA, Quiezi RG, Guion-Almeida ML, Legnaro C and Richieri-Costa A.


book

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
PLoS Genet. 8 (5), E1002695 (2012)
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA and Borecki IB.


book

Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management
Arch Facial Plast Surg 13 (6), 415-420 (2011)
Pham NS, Rafii A, Liu J, Boyadjiev SA and Tollefson TT.


book

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia
PLoS ONE 5 (7), E11493 (2010)
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC and Murray JC.


book

Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene
Am. J. Hum. Genet. 84 (5), 698-705 (2009)
Twigg SR, Versnel SL, Nurnberg G, Lees MM, Bhat M, Hammond P, Hennekam RC, Hoogeboom AJ, Hurst JA, Johnson D, Robinson AA, Scambler PJ, Gerrelli D, Nurnberg P, Mathijssen IM and Wilkie AO.


book

The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47
Mol. Endocrinol. 20 (11), 2876-2889 (2006)
Mirasierra M and Vallejo M.


book

The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation
J. Biol. Chem. 279 (36), 38062-38071 (2004)
Perez-Villamil B, Mirasierra M and Vallejo M.


book

Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma
Genes Chromosomes Cancer 33 (3), 285-294 (2002)
Wimmer K, Zhu Xx XX, Rouillard JM, Ambros PF, Lamb BJ, Kuick R, Eckart M, Weinhausl A, Fonatsch C and Hanash SM.


book

Pancreatic beta cells express a diverse set of homeobox genes
Proc. Natl. Acad. Sci. U.S.A. 91 (25), 12203-12207 (1994)
Rudnick A, Ling TY, Odagiri H, Rutter WJ and German MS.


 
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