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GALR1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GALR1
Entrez Gene ID 2587
Full Name galanin receptor 1
Synonyms GALNR, GALNR1
General protein information
Preferred Names
galanin receptor type 1
Names
galanin receptor type 1
GAL1-R
GALR-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q23

Summary The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600377


mRNA and Protein(s)

mRNA Protein Name
NM_001480 NP_001471 galanin receptor type 1



Homo sapiens (human) GALR1 NP_001471.2
Pan troglodytes (chimpanzee) GALR1 XP_523975.2
Macaca mulatta (Rhesus monkey) GALR1 XP_001086740.1
Canis lupus familiaris (dog) GALR1 XP_541048.2
Bos taurus (cattle) GALR1 NP_001179170.1
Mus musculus (house mouse) Galr1 NP_032108.1
Rattus norvegicus (Norway rat) Galr1 NP_037090.2
Gallus gallus (chicken) GALR1 NP_001121534.1
Danio rerio (zebrafish) galr1 XP_696215.1
Caenorhabditis elegans CELE_Y54E2A.1 NP_497057.2
Xenopus (Silurana) tropicalis (western clawed frog) galr1 NP_001107355.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GALR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu17969
NM_001480 Homo sapiens galanin receptor 1 (GALR1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$144.50-$202.30
$289.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17969
Clone ID Related Accession (Same CDS sequence) NM_001480
Accession Version NM_001480.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1050bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product galanin receptor type 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC100863.2 and U23854.1. This sequence is a reference standard in the RefSeqGene project. On Feb 6, 2008 this sequence version replaced gi:6031165. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC095530.1, L34339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGACTGCACA GACAGTTCTG GTGGTGGTTG TGGTGTTTGG AATCTCCTGG
CTGCCGCACC ACATCATCCA TCTCTGGGCT GAGTTTGGAG TTTTCCCGCT GACGCCGGCT
TCCTTCCTCT TCAGAATCAC CGCCCACTGC CTGGCGTACA GCAATTCCTC CGTGAATCCT
ATCATTTATG CATTTCTCTC TGAAAATTTC AGGAAGGCCT ATAAACAAGT GTTCAAGTGT
CACATTCGCA AAGATTCACA CCTGAGTGAT ACTAAAGAAA GTAAAAGTCG AATAGACACC
CCACCATCAA CCAATTGTAC TCATGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001471.2
CDS498..1547
Misc Feature(1)606..668(+)
Misc Feature(2)666..1406(+)
Misc Feature(3)708..770(+)
Misc Feature(4)825..890(+)
Misc Feature(5)951..1013(+)
Misc Feature(6)1098..1160(+)
Misc Feature(7)1242..1304(+)
Misc Feature(8)1311..1373(+)
Exon (1)1..1163
Gene:GALR1
Gene Synonym:
Exon (2)1164..1229
Gene:GALR1
Gene Synonym:
Exon (3)1230..2787
Gene:GALR1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001480
Organism Homo sapiens (human)
Definition Homo sapiens galanin receptor 1 (GALR1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001480

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGACTGCACA GACAGTTCTG GTGGTGGTTG TGGTGTTTGG AATCTCCTGG
CTGCCGCACC ACATCATCCA TCTCTGGGCT GAGTTTGGAG TTTTCCCGCT GACGCCGGCT
TCCTTCCTCT TCAGAATCAC CGCCCACTGC CTGGCGTACA GCAATTCCTC CGTGAATCCT
ATCATTTATG CATTTCTCTC TGAAAATTTC AGGAAGGCCT ATAAACAAGT GTTCAAGTGT
CACATTCGCA AAGATTCACA CCTGAGTGAT ACTAAAGAAA GTAAAAGTCG AATAGACACC
CCACCATCAA CCAATTGTAC TCATGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer
Int. J. Gynecol. Cancer 23 (6), 1050-1055 (2013)
Doufekas K, Hadwin R, Kandimalla R, Jones A, Mould T, Crowe S, Olaitan A, Macdonald N, Fiegl H, Wik E, Salvesen HB and Widschwendter M.


book

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer
Clin. Cancer Res. 18 (19), 5412-5426 (2012)
Stevenson L, Allen WL, Turkington R, Jithesh PV, Proutski I, Stewart G, Lenz HJ, Van Schaeybroeck S, Longley DB and Johnston PG.


book

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
PLoS ONE 7 (12), E51954 (2012)
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA and Butte NF.


book

The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence
Neuropsychopharmacology 36 (11), 2339-2348 (2011)
Jackson KJ, Chen X, Miles MF, Harenza J and Damaj MI.


book

The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment
Neuropsychopharmacology 36 (7), 1412-1420 (2011)
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN and Cubells JF.


book

Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract
Biochem. Biophys. Res. Commun. 222 (2), 379-385 (1996)
Lorimer DD and Benya RV.


book

Delineation of the peptide binding site of the human galanin receptor
EMBO J. 15 (2), 236-244 (1996)
Kask K, Berthold M, Kahl U, Nordvall G and Bartfai T.


book

Identification and biochemical characterization of the human brain galanin receptor
J. Mol. Endocrinol. 13 (3), 347-356 (1994)
Walli R, Schafer H, Morys-Wortmann C, Paetzold G, Nustede R and Schmidt WE.


book

Molecular cloning of a functional human galanin receptor
Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9780-9783 (1994)
Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M and Mayaux JF.


book

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
J. Biol. Chem. 263 (14), 6656-6664 (1988)
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M and Kaziro Y.


 
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