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KIF1BP cDNA ORF clone, Homo sapiens (human)

Gene Symbol KIF1BP
Entrez Gene ID 26128
Full Name KIF1 binding protein
Synonyms KBP, KIAA1279, TTC20
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22.1

Summary This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. [provided by RefSeq, Mar 2010]. lac of sum
Disorder MIM:

609367

Disorder Html: Goldberg-Shprintzen megacolon syndrome, 609460 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_015634 NP_056449 KIF1-binding protein


Homo sapiens (human) KIAA1279 NP_056449.1
Pan troglodytes (chimpanzee) KIAA1279 XP_507827.3
Macaca mulatta (Rhesus monkey) LOC717469 XP_002805751.1
Canis lupus familiaris (dog) KIAA1279 XP_536374.3
Bos taurus (cattle) KIAA1279 NP_001029731.1
Mus musculus (house mouse) 2510003E04Rik NP_082473.2
Rattus norvegicus (Norway rat) LOC606294 NP_001026797.1
Gallus gallus (chicken) KIAA1279 NP_001007945.1
Danio rerio (zebrafish) kbp NP_001013480.3
Drosophila melanogaster (fruit fly) CG14043 NP_608886.1
Xenopus (Silurana) tropicalis (western clawed frog) kiaa1279 NP_001072796.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KIF1BP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIF1BP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26093
NM_015634 Homo sapiens KIAA1279 (KIAA1279), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$259.50-$363.30
$519.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26093
Clone ID Related Accession (Same CDS sequence) NM_015634
Accession Version NM_015634.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1866bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product KIF1-binding protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA292451.1, BC006427.1, AL050190.1 and AI491993.1. This sequence is a reference standard in the RefSeqGene project. On Mar 18, 2010 this sequence version replaced gi:72384372. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC006427.1, AB033105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAACG TTCCGTGGGC AGAGGTCTGC GAGAAATTCC AGGCGGCGCT CGCTCTGTCG 
CGGGTGGAAC TGCATAAAAA TCCGGAGAAG GAACCATACA AGTCCAAATA CAGCGCCCGG
GCGCTACTGG AAGAGGTCAA GGCGCTGCTC GGCCCTGCGC CTGAGGACGA GGATGAGCGG
CCTGAGGCCG AGGACGGCCC GGGTGCCGGT GACCACGCCC TGGGGCTGCC GGCTGAGGTG
GTGGAGCCCG AGGGGCCCGT CGCCCAGCGA GCGGTGAGGC TGGCAGTCAT CGAGTTCCAC
CTCGGGGTGA ACCACATCGA CACGGAGGAG CTGTCGGCGG GGGAGGAGCA CCTGGTGAAA
TGCCTGCGGC TGCTGCGCAG GTACCGGCTC TCGCACGACT GCATCTCTCT CTGCATCCAG
GCGCAGAATA ACCTGGGTAT CTTGTGGTCT GAAAGAGAAG AAATTGAAAC TGCACAGGCT
TACCTAGAGT CATCAGAAGC ACTATATAAT CAGTATATGA AAGAGGTTGG GAGTCCTCCT
CTTGATCCTA CTGAGCGTTT TCTTCCTGAA GAAGAGAAAC TTACTGAACA AGAGAGATCA
AAAAGATTTG AAAAGGTTTA TACTCATAAC CTATATTACC TAGCTCAAGT CTACCAGCAT
CTGGAAATGT TTGAGAAGGC TGCTCACTAT TGCCATAGTA CACTAAAACG CCAGCTTGAG
CACAATGCCT ACCATCCTAT AGAGTGGGCT ATCAATGCTG CTACCTTGTC ACAGTTTTAC
ATCAATAAGC TATGCTTTAT GGAGGCCAGG CACTGTTTAT CAGCTGCTAA TGTCATTTTT
GGTCAAACTG GAAAGATCTC AGCCACAGAA GACACTCCTG AAGCTGAAGG AGAAGTGCCA
GAGCTTTATC ATCAAAGAAA GGGGGAAATA GCAAGGTGCT GGATCAAATA CTGTTTGACT
CTCATGCAGA ATGCCCAACT CTCCATGCAG GACAACATAG GAGAGCTTGA TCTTGATAAA
CAGTCTGAAC TTAGAGCTTT AAGGAAAAAA GAACTAGATG AGGAGGAAAG CATTCGGAAA
AAAGCTGTGC AGTTTGGAAC CGGTGAACTG TGTGATGCCA TCTCTGCAGT AGAAGAGAAA
GTGAGCTACT TGAGACCTTT AGATTTTGAA GAAGCCAGAG AACTTTTCTT ATTGGGTCAG
CACTATGTCT TTGAGGCAAA AGAGTTCTTT CAGATTGATG GTTATGTCAC TGACCATATT
GAAGTTGTCC AAGACCACAG TGCTCTGTTT AAGGTGCTTG CATTCTTTGA AACTGACATG
GAGAGACGGT GCAAGATGCA TAAACGCAGA ATAGCCATGC TAGAGCCCCT AACTGTAGAC
CTGAATCCAC AGTATTATCT GTTGGTCAAC AGACAGATCC AGTTTGAAAT TGCACATGCT
TACTATGATA TGATGGATTT GAAGGTTGCC ATTGCTGACA GGCTAAGGGA TCCTGATTCA
CACATTGTAA AAAAAATAAA TAATCTTAAT AAGTCAGCAC TGAAGTACTA CCAGCTCTTC
TTAGACTCCC TGAGAGACCC AAATAAAGTA TTCCCTGAGC ATATAGGGGA AGATGTTCTT
CGCCCTGCCA TGTTAGCTAA GTTTCGAGTT GCCCGTCTCT ATGGCAAAAT CATTACTGCA
GATCCCAAGA AAGAGCTGGA AAATTTGGCA ACATCATTGG AACATTACAA ATTTATTGTT
GATTACTGTG AAAAGCATCC TGAGGCCGCC CAGGAAATAG AAGTTGAGCT AGAACTTAGT
AAAGAGATGG TTAGTCTTCT CCCAACAAAA ATGGAGAGAT TCAGAACCAA GATGGCCCTG
ACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_056449.1
CDS113..1978
Misc Feature(1)848..1957(+)
Exon (1)1..538
Gene:KIAA1279
Gene Synonym:
Exon (2)539..637
Gene:KIAA1279
Gene Synonym:
Exon (3)638..717
Gene:KIAA1279
Gene Synonym:
Exon (4)718..901
Gene:KIAA1279
Gene Synonym:
Exon (5)902..986
Gene:KIAA1279
Gene Synonym:
Exon (6)987..1102
Gene:KIAA1279
Gene Synonym:
Exon (7)1103..2545
Gene:KIAA1279
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_015634
Organism Homo sapiens (human)
Definition Homo sapiens KIAA1279 (KIAA1279), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_015634

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAACG TTCCGTGGGC AGAGGTCTGC GAGAAATTCC AGGCGGCGCT CGCTCTGTCG 
CGGGTGGAAC TGCATAAAAA TCCGGAGAAG GAACCATACA AGTCCAAATA CAGCGCCCGG
GCGCTACTGG AAGAGGTCAA GGCGCTGCTC GGCCCTGCGC CTGAGGACGA GGATGAGCGG
CCTGAGGCCG AGGACGGCCC GGGTGCCGGT GACCACGCCC TGGGGCTGCC GGCTGAGGTG
GTGGAGCCCG AGGGGCCCGT CGCCCAGCGA GCGGTGAGGC TGGCAGTCAT CGAGTTCCAC
CTCGGGGTGA ACCACATCGA CACGGAGGAG CTGTCGGCGG GGGAGGAGCA CCTGGTGAAA
TGCCTGCGGC TGCTGCGCAG GTACCGGCTC TCGCACGACT GCATCTCTCT CTGCATCCAG
GCGCAGAATA ACCTGGGTAT CTTGTGGTCT GAAAGAGAAG AAATTGAAAC TGCACAGGCT
TACCTAGAGT CATCAGAAGC ACTATATAAT CAGTATATGA AAGAGGTTGG GAGTCCTCCT
CTTGATCCTA CTGAGCGTTT TCTTCCTGAA GAAGAGAAAC TTACTGAACA AGAGAGATCA
AAAAGATTTG AAAAGGTTTA TACTCATAAC CTATATTACC TAGCTCAAGT CTACCAGCAT
CTGGAAATGT TTGAGAAGGC TGCTCACTAT TGCCATAGTA CACTAAAACG CCAGCTTGAG
CACAATGCCT ACCATCCTAT AGAGTGGGCT ATCAATGCTG CTACCTTGTC ACAGTTTTAC
ATCAATAAGC TATGCTTTAT GGAGGCCAGG CACTGTTTAT CAGCTGCTAA TGTCATTTTT
GGTCAAACTG GAAAGATCTC AGCCACAGAA GACACTCCTG AAGCTGAAGG AGAAGTGCCA
GAGCTTTATC ATCAAAGAAA GGGGGAAATA GCAAGGTGCT GGATCAAATA CTGTTTGACT
CTCATGCAGA ATGCCCAACT CTCCATGCAG GACAACATAG GAGAGCTTGA TCTTGATAAA
CAGTCTGAAC TTAGAGCTTT AAGGAAAAAA GAACTAGATG AGGAGGAAAG CATTCGGAAA
AAAGCTGTGC AGTTTGGAAC CGGTGAACTG TGTGATGCCA TCTCTGCAGT AGAAGAGAAA
GTGAGCTACT TGAGACCTTT AGATTTTGAA GAAGCCAGAG AACTTTTCTT ATTGGGTCAG
CACTATGTCT TTGAGGCAAA AGAGTTCTTT CAGATTGATG GTTATGTCAC TGACCATATT
GAAGTTGTCC AAGACCACAG TGCTCTGTTT AAGGTGCTTG CATTCTTTGA AACTGACATG
GAGAGACGGT GCAAGATGCA TAAACGCAGA ATAGCCATGC TAGAGCCCCT AACTGTAGAC
CTGAATCCAC AGTATTATCT GTTGGTCAAC AGACAGATCC AGTTTGAAAT TGCACATGCT
TACTATGATA TGATGGATTT GAAGGTTGCC ATTGCTGACA GGCTAAGGGA TCCTGATTCA
CACATTGTAA AAAAAATAAA TAATCTTAAT AAGTCAGCAC TGAAGTACTA CCAGCTCTTC
TTAGACTCCC TGAGAGACCC AAATAAAGTA TTCCCTGAGC ATATAGGGGA AGATGTTCTT
CGCCCTGCCA TGTTAGCTAA GTTTCGAGTT GCCCGTCTCT ATGGCAAAAT CATTACTGCA
GATCCCAAGA AAGAGCTGGA AAATTTGGCA ACATCATTGG AACATTACAA ATTTATTGTT
GATTACTGTG AAAAGCATCC TGAGGCCGCC CAGGAAATAG AAGTTGAGCT AGAACTTAGT
AAAGAGATGG TTAGTCTTCT CCCAACAAAA ATGGAGAGAT TCAGAACCAA GATGGCCCTG
ACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Homozygous truncating mutation of the KBP gene, encoding a KIF1B-binding protein, in a familial case of fetal polymicrogyria
Neurogenetics 14 (3-4), 215-224 (2013)
Valence S, Poirier K, Lebrun N, Saillour Y, Sonigo P, Bessieres B, Attie-Bitach T, Benachi A, Masson C, Encha-Razavi F, Chelly J and Bahi-Buisson N.


book

KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome
Hum. Mol. Genet. 22 (12), 2387-2399 (2013)
Drevillon L, Megarbane A, Demeer B, Matar C, Benit P, Briand-Suleau A, Bodereau V, Ghoumid J, Nasser M, Decrouy X, Doco-Fenzy M, Rustin P, Gaillard D, Goossens M and Giurgea I.


book

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
Am. J. Hum. Genet. 78 (1), 78-88 (2006)
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J and Goate A.


book

Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems
Am. J. Hum. Genet. 77 (1), 120-126 (2005)
Brooks AS, Bertoli-Avella AM, Burzynski GM, Breedveld GJ, Osinga J, Boven LG, Hurst JA, Mancini GM, Lequin MH, de Coo RF, Matera I, de Graaff E, Meijers C, Willems PJ, Tibboel D, Oostra BA and Hofstra RM.


book

The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein
BMC Cell Biol. 6, 35 (2005)
Wozniak MJ, Melzer M, Dorner C, Haring HU and Lammers R.


book

Hirschsprung Disease Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Parisi,M.A.


 
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