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GBX2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GBX2
Entrez Gene ID 2637
Full Name gastrulation brain homeobox 2
General protein information
Preferred Names
homeobox protein GBX-2
Names
homeobox protein GBX-2
gastrulation brain homeo box 2
gastrulation and brain-specific homeobox protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37.2

Summary lac of sum
Disorder MIM:

601135


mRNA and Protein(s)

mRNA Protein Name
NM_001485 NP_001476 homeobox protein GBX-2 isoform 1
NM_001301687 NP_001288616 homeobox protein GBX-2 isoform 2



Homo sapiens (human) GBX2 NP_001476.2
Pan troglodytes (chimpanzee) GBX2 XP_526072.2
Macaca mulatta (Rhesus monkey) GBX2 XP_001082998.1
Canis lupus familiaris (dog) GBX2 XP_543300.1
Bos taurus (cattle) GBX2 NP_001179074.1
Mus musculus (house mouse) Gbx2 NP_034392.1
Rattus norvegicus (Norway rat) Gbx2 NP_446160.1
Gallus gallus (chicken) GBX2 NP_990399.1
Danio rerio (zebrafish) gbx2 NP_694496.1
Xenopus (Silurana) tropicalis (western clawed frog) gbx2.2 NP_001011472.1
Xenopus (Silurana) tropicalis (western clawed frog) gbx2 XP_002932046.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GBX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GBX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25066 NM_001485 Homo sapiens gastrulation brain homeobox 2 (GBX2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
OHu36088 NM_001301687 Homo sapiens gastrulation brain homeobox 2 (GBX2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25066
Clone ID Related Accession (Same CDS sequence) NM_001485
Accession Version NM_001485.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1047bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein GBX-2 isoform 1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC137448.1, BF115559.1, AA176205.1 and BE463746.1. On Sep 6, 2014 this sequence version replaced gi:45593143. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC137449.1, DR760752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGAGCGCAG CGTTCCCGCC GTCGCTGATG ATGATGCAGC GCCCGCTGGG GAGTAGCACC 
GCCTTCAGCA TAGACTCGCT GATCGGCAGC CCGCCGCAGC CCAGCCCCGG CCATTTCGTC
TACACCGGCT ACCCCATGTT CATGCCCTAC CGGCCGGTAG TGCTGCCGCC GCCGCCGCCG
CCGCCGCCCG CGCTGCCCCA GGCCGCGCTG CAGCCAGCGC TGCCGCCCGC ACACCCTCAC
CACCAGATCC CCAGCCTGCC CACAGGCTTC TGCTCCAGCC TGGCGCAGGG CATGGCGCTC
ACCTCTACGC TCATGGCCAC GCTCCCCGGC GGCTTCTCCG CGTCGCCCCA GCACCAGGAG
GCGGCAGCGG CCCGCAAGTT CGCGCCGCAG CCGCTGCCCG GCGGCGGTAA CTTCGACAAG
GCGGAGGCGC TGCAGGCTGA CGCGGAGGAC GGCAAAGGCT TCCTGGCCAA AGAGGGCTCG
CTGCTCGCCT TCTCCGCGGC CGAGACGGTG CAGGCTTCGC TCGTCGGGGC TGTCCGAGGG
CAAGGGAAAG ACGAGTCAAA GGTGGAAGAC GACCCGAAGG GCAAGGAGGA GAGCTTCTCG
CTGGAGAGCG ATGTGGACTA CAGCTCGGAT GACAATCTGA CTGGCCAGGC AGCTCACAAG
GAGGAAGACC CGGGCCACGC GCTGGAGGAG ACCCCGCCGA GCAGCGGCGC CGCGGGCAGC
ACCACGTCTA CGGGCAAGAA CCGGCGGCGG CGGACTGCCT TCACCAGCGA GCAGCTGCTG
GAGCTAGAGA AGGAGTTCCA CTGCAAAAAG TACCTCTCCT TGACCGAGCG CTCGCAGATC
GCCCACGCCC TCAAACTCAG CGAGGTGCAG GTGAAAATCT GGTTCCAGAA CCGACGGGCC
AAGTGGAAAC GGGTGAAGGC AGGCAATGCC AATTCCAAGA CAGGGGAGCC CTCCCGGAAC
CCTAAGATCG TCGTCCCCAT CCCTGTCCAC GTCAGCAGGT TCGCTATCAG AAGTCAGCAT
CAGCAGCTAG AACAGGCCCG GCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001476.2
CDS39..1085
Misc Feature(1)780..956(+)
Misc Feature(2)780..950(+)
Misc Feature(3)786..938(+)
Exon (1)1..561
Gene:GBX2
Gene Synonym:
Exon (2)562..1763
Gene:GBX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001485
Organism Homo sapiens (human)
Definition Homo sapiens gastrulation brain homeobox 2 (GBX2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001485

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGAGCGCAG CGTTCCCGCC GTCGCTGATG ATGATGCAGC GCCCGCTGGG GAGTAGCACC 
GCCTTCAGCA TAGACTCGCT GATCGGCAGC CCGCCGCAGC CCAGCCCCGG CCATTTCGTC
TACACCGGCT ACCCCATGTT CATGCCCTAC CGGCCGGTAG TGCTGCCGCC GCCGCCGCCG
CCGCCGCCCG CGCTGCCCCA GGCCGCGCTG CAGCCAGCGC TGCCGCCCGC ACACCCTCAC
CACCAGATCC CCAGCCTGCC CACAGGCTTC TGCTCCAGCC TGGCGCAGGG CATGGCGCTC
ACCTCTACGC TCATGGCCAC GCTCCCCGGC GGCTTCTCCG CGTCGCCCCA GCACCAGGAG
GCGGCAGCGG CCCGCAAGTT CGCGCCGCAG CCGCTGCCCG GCGGCGGTAA CTTCGACAAG
GCGGAGGCGC TGCAGGCTGA CGCGGAGGAC GGCAAAGGCT TCCTGGCCAA AGAGGGCTCG
CTGCTCGCCT TCTCCGCGGC CGAGACGGTG CAGGCTTCGC TCGTCGGGGC TGTCCGAGGG
CAAGGGAAAG ACGAGTCAAA GGTGGAAGAC GACCCGAAGG GCAAGGAGGA GAGCTTCTCG
CTGGAGAGCG ATGTGGACTA CAGCTCGGAT GACAATCTGA CTGGCCAGGC AGCTCACAAG
GAGGAAGACC CGGGCCACGC GCTGGAGGAG ACCCCGCCGA GCAGCGGCGC CGCGGGCAGC
ACCACGTCTA CGGGCAAGAA CCGGCGGCGG CGGACTGCCT TCACCAGCGA GCAGCTGCTG
GAGCTAGAGA AGGAGTTCCA CTGCAAAAAG TACCTCTCCT TGACCGAGCG CTCGCAGATC
GCCCACGCCC TCAAACTCAG CGAGGTGCAG GTGAAAATCT GGTTCCAGAA CCGACGGGCC
AAGTGGAAAC GGGTGAAGGC AGGCAATGCC AATTCCAAGA CAGGGGAGCC CTCCCGGAAC
CCTAAGATCG TCGTCCCCAT CCCTGTCCAC GTCAGCAGGT TCGCTATCAG AAGTCAGCAT
CAGCAGCTAG AACAGGCCCG GCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36088
Clone ID Related Accession (Same CDS sequence) NM_001301687
Accession Version NM_001301687.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 669bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-MAY-2015
Organism Homo sapiens (human)
Product homeobox protein GBX-2 isoform 2
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC144646.1, BF115559.1, AA176205.1 and BE463746.1. Transcript Variant: This variant (2) contains an alternate exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC144646.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA962337, SAMEA962346 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGCGCAG CGTTCCCGCC GTCGCTGATG ATGATGCAGC GCCCGCTGGG GAGTAGCACC 
GCCTTCAGCA TAGACTCGCT GATCGGCAGC CCGCCGCAGC CCAGCCCCGG CCATTTCGTC
TACACCGGCT ACCCCATGTT CATGCCCTAC CGGCCGGTAG TGCTGCCGCC GCCGCCGCCG
CCGCCGCCCG CGCTGCCCCA GGCCGCGCTG CAGCCAGCGC TGCCGCCCGC ACACCCTCAC
CACCAGATCC CCAGCCTGCC CACAGGCTTC TGCTCCAGCC TGGCGCAGGG CATGGCGCTC
ACCTCTACGC TCATGGCCAC GCTCCCCGGC GGCTTCTCCG CGTCGCCCCA GCACCAGGAG
GCGGCAGCGG CCCGCAAGTT CGCGCCGCAG CCGCTGCCCG GCGGCGGTAA CTTCGACAAG
GCGGAGGCGC TGCAGGCTGA CGCGGAGGAC GGCAAAGGCT TCCTGGCCAA AGAGGGCTCG
CTGCTCGCCT TCTCCGCGGC CGAGACGGTG CAGGCTTCGC TCGGCCGCCT CTGCCGCTCC
GCGGTGACCT GGGGTTCCGG TCGGGGCTGT CCGAGGGCAA GGGAAAGACG AGTCAAAGGT
GGAAGACGAC CCGAAGGGCA AGGAGGAGAG CTTCTCGCTG GAGAGCGATG TGGACTACAG
CTCGGATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001288616.1
CDS39..707
Misc Feature(1)567..>647(+)
Exon (1)1..561
Gene:GBX2
Gene Synonym:
Exon (2)562..598
Gene:GBX2
Gene Synonym:
Exon (3)599..1800
Gene:GBX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001301687
Organism Homo sapiens (human)
Definition Homo sapiens gastrulation brain homeobox 2 (GBX2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001301687

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGCGCAG CGTTCCCGCC GTCGCTGATG ATGATGCAGC GCCCGCTGGG GAGTAGCACC 
GCCTTCAGCA TAGACTCGCT GATCGGCAGC CCGCCGCAGC CCAGCCCCGG CCATTTCGTC
TACACCGGCT ACCCCATGTT CATGCCCTAC CGGCCGGTAG TGCTGCCGCC GCCGCCGCCG
CCGCCGCCCG CGCTGCCCCA GGCCGCGCTG CAGCCAGCGC TGCCGCCCGC ACACCCTCAC
CACCAGATCC CCAGCCTGCC CACAGGCTTC TGCTCCAGCC TGGCGCAGGG CATGGCGCTC
ACCTCTACGC TCATGGCCAC GCTCCCCGGC GGCTTCTCCG CGTCGCCCCA GCACCAGGAG
GCGGCAGCGG CCCGCAAGTT CGCGCCGCAG CCGCTGCCCG GCGGCGGTAA CTTCGACAAG
GCGGAGGCGC TGCAGGCTGA CGCGGAGGAC GGCAAAGGCT TCCTGGCCAA AGAGGGCTCG
CTGCTCGCCT TCTCCGCGGC CGAGACGGTG CAGGCTTCGC TCGGCCGCCT CTGCCGCTCC
GCGGTGACCT GGGGTTCCGG TCGGGGCTGT CCGAGGGCAA GGGAAAGACG AGTCAAAGGT
GGAAGACGAC CCGAAGGGCA AGGAGGAGAG CTTCTCGCTG GAGAGCGATG TGGACTACAG
CTCGGATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
Science 340 (6139), 1467-1471 (2013)
Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A, Albrecht E, Alizadeh BZ, Amin N, Barnard J, Baumeister SE, Benke KS, Bielak LF, Boatman JA, Boyle PA, Davies G, de Leeuw C, Eklund N, Evans DS, Ferhmann R, Fischer K, Gieger C, Gjessing HK, Hagg S, Harris JR, Hayward C, Holzapfel C, Ibrahim-Verbaas CA, Ingelsson E, Jacobsson B, Joshi PK, Jugessur A, Kaakinen M, Kanoni S, Karjalainen J, Kolcic I, Kristiansson K, Kutalik Z, Lahti J, Lee SH, Lin P, Lind PA, Liu Y, Lohman K, Loitfelder M, McMahon G, Vidal PM, Meirelles O, Milani L, Myhre R, Nuotio ML, Oldmeadow CJ, Petrovic KE, Peyrot WJ, Polasek O, Quaye L, Reinmaa E, Rice JP, Rizzi TS, Schmidt H, Schmidt R, Smith AV, Smith JA, Tanaka T, Terracciano A, van der Loos MJ, Vitart V, Volzke H, Wellmann J, Yu L, Zhao W, Allik J, Attia JR, Bandinelli S, Bastardot F, Beauchamp J, Bennett DA, Berger K, Bierut LJ, Boomsma DI, Bultmann U, Campbell H, Chabris CF, Cherkas L, Chung MK, Cucca F, de Andrade M, De Jager PL, De Neve JE, Deary IJ, Dedoussis GV, Deloukas P, Dimitriou M, Eiriksdottir G, Elderson MF, Eriksson JG, Evans DM, Faul JD, Ferrucci L, Garcia ME, Gronberg H, Guethnason V, Hall P, Harris JM, Harris TB, Hastie ND, Heath AC, Hernandez DG, Hoffmann W, Hofman A, Holle R, Holliday EG, Hottenga JJ, Iacono WG, Illig T, Jarvelin MR, Kahonen M, Kaprio J, Kirkpatrick RM, Kowgier M, Latvala A, Launer LJ, Lawlor DA, Lehtimaki T, Li J, Lichtenstein P, Lichtner P, Liewald DC, Madden PA, Magnusson PK, Makinen TE, Masala M, McGue M, Metspalu A, Mielck A, Miller MB, Montgomery GW, Mukherjee S, Nyholt DR, Oostra BA, Palmer LJ, Palotie A, Penninx BW, Perola M, Peyser PA, Preisig M, Raikkonen K, Raitakari OT, Realo A, Ring SM, Ripatti S, Rivadeneira F, Rudan I, Rustichini A, Salomaa V, Sarin AP, Schlessinger D, Scott RJ, Snieder H, St Pourcain B, Starr JM, Sul JH, Surakka I, Svento R, Teumer A, Tiemeier H, van Rooij FJ, Van Wagoner DR, Vartiainen E, Viikari J, Vollenweider P, Vonk JM, Waeber G, Weir DR, Wichmann HE, Widen E, Willemsen G, Wilson JF, Wright AF, Conley D, Davey-Smith G, Franke L, Groenen PJ, Hofman A, Johannesson M, Kardia SL, Krueger RF, Laibson D, Martin NG, Meyer MN, Posthuma D, Thurik AR, Timpson NJ, Uitterlinden AG, van Duijn CM, Visscher PM, Benjamin DJ, Cesarini D and Koellinger PD.


book

Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer
Clin. Cancer Res. 19 (10), 2723-2733 (2013)
Yu KD, Zhu R, Zhan M, Rodriguez AA, Yang W, Wong S, Makris A, Lehmann BD, Chen X, Mayer I, Pietenpol JA, Shao ZM, Symmans WF and Chang JC.


book

New genetic associations detected in a host response study to hepatitis B vaccine
Genes Immun. 11 (3), 232-238 (2010)
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML and Seielstad M.


book

Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors
Mol. Cell. Biol. 27 (1), 340-351 (2007)
Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A and Czerny T.


book

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
J. Clin. Invest. 115 (6), 1503-1521 (2005)
Glinsky GV, Berezovska O and Glinskii AB.


book

Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene
Clin. Cancer Res. 6 (2), 493-497 (2000)
Gao AC, Lou W and Isaacs JT.


book

Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity
Cancer Res. 58 (7), 1391-1394 (1998)
Gao AC, Lou W and Isaacs JT.


book

The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation
Cell 91 (2), 185-195 (1997)
Kowenz-Leutz E, Herr P, Niss K and Leutz A.


book

Characterization and sequence analysis of the human homeobox-containing gene GBX2
Genomics 31 (3), 335-342 (1996)
Lin X, Swaroop A, Vaccarino FM, Murtha MT, Haas M, Ji X, Ruddle FH and Leckman JF.


book

The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans
FEBS Lett. 336 (1), 107-110 (1993)
Matsui T, Hirai M, Hirano M and Kurosawa Y.


 
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