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AMELX amelogenin, X-linked [Homo sapiens (human)]

Gene Symbol AMELX
Entrez Gene ID 265
Full Name amelogenin, X-linked
Synonyms AI1E, AIH1, ALGN, AMG, AMGL, AMGX
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp22.31-p22.1

Summary This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300391

Disorder Html: Amelogenesis imperfecta, hypoplastic/hypomaturation type, 301200 (3)





The following AMELX gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMELX gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25376 XM_011545489 PREDICTED: Homo sapiens amelogenin, X-linked (AMELX), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $199
OHu25531 NM_001142 Homo sapiens amelogenin, X-linked (AMELX), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu25376 NM_182680 Homo sapiens amelogenin, X-linked (AMELX), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $269
OHu25363 NM_182681 Homo sapiens amelogenin, X-linked (AMELX), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu25376
Accession Version XM_011545489.1
Sequence Information ORF Nucleotide Sequence (Length: 618bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product amelogenin, X isoform isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167197.2) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT
ATCAATGTTG ACAGGACTGC ATTAGTGCTT ACCCCTTTGA AGTGGTACCA GAGCATAAGG
CCACCGTACC CTTCCTATGG TTACGAGCCC ATGGGTGGAT GGCTGCACCA CCAAATCATC
CCCGTGCTGT CCCAACAGCA CCCCCCGACT CACACCCTGC AGCCTCATCA CCACATCCCA
GTGGTGCCAG CTCAGCAGCC CGTGATCCCC CAGCAACCAA TGATGCCCGT TCCTGGCCAA
CACTCCATGA CTCCAATCCA ACACCACCAG CCAAACCTCC CTCCGCCCGC CCAGCAGCCC
TACCAGCCCC AGCCTGTTCA GCCACAGCCT CACCAGCCCA TGCAGCCCCA GCCACCTGTG
CACCCCATGC AGCCCCTGCC GCCACAGCCA CCTCTGCCTC CGATGTTCCC CATGCAGCCC
CTGCCTCCCA TGCTTCCTGA TCTGACTCTG GAAGCTTGGC CATCAACAGA CAAGACCAAG
CGGGAGGAAG TGGATTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011543791.1
CDS219..836
Misc Feature(1)300..833(+)
Translation
Position Chain Variation Link
63 63 a, t dbSNP:755674508
144 144 a, g dbSNP:201841630
212 212 c, t dbSNP:764153884
220 220 c, t dbSNP:104894737
226 226 a, c dbSNP:753863554
229 229 c, g dbSNP:104894738
232 232 -, ttttatttg dbSNP:387906488
236 236 a, g dbSNP:757235287
248 248 c, g dbSNP:780336512
253 253 a, g dbSNP:751652555
268 268 c, t dbSNP:755158864
279 279 c, t dbSNP:776498485
289 289 g, t dbSNP:776551701
296 296 g, t dbSNP:145299463
314 314 c, g dbSNP:745846151
343 343 a, g dbSNP:746714110
370 370 c, t dbSNP:104894733
373 373 -, c dbSNP:387906487
383 383 c, g dbSNP:765738846
389 389 c, g dbSNP:431825176
391 391 a, g dbSNP:431825177
392 392 a, c dbSNP:431825178
399 399 c, t dbSNP:758813809
403 403 c, t dbSNP:144955572
404 404 a, g dbSNP:149068672
409 409 c, t dbSNP:374272157
415 415 a, g dbSNP:760691566
422 422 c, t dbSNP:368149347
423 423 a, g dbSNP:754022687
426 426 a, c dbSNP:104894736
430 430 c, t dbSNP:761996476
431 431 a, g dbSNP:765687165
432 432 a, g dbSNP:750746199
441 441 c, g dbSNP:758945581
442 442 c, t dbSNP:780365505
447 447 c, g dbSNP:751135700
462 462 a, g dbSNP:371530769
476 476 a, g dbSNP:780818544
478 478 a, c dbSNP:749213434
479 479 c, t dbSNP:2106416
482 482 c, t dbSNP:778441921
484 484 a, c, t dbSNP:148259441
485 485 a, g, t dbSNP:142884100
493 493 a, c dbSNP:768768651
494 494 c, g dbSNP:771775925
515 515 c, t dbSNP:776675035
530 530 a, t dbSNP:762158191
539 539 c, t dbSNP:765306052
540 540 a, g dbSNP:373800800
552 552 a, c dbSNP:763177333
554 554 a, g dbSNP:766939481
558 558 a, g dbSNP:752151612
566 566 c, g, t dbSNP:200842202
567 567 a, g dbSNP:367556910
578 578 a, g dbSNP:755797941
584 584 c, t dbSNP:777235911
593 593 a, t dbSNP:749154172
596 596 a, c dbSNP:756968232
603 603 c, t dbSNP:760321133
604 604 a, c dbSNP:745822682
622 622 c, t dbSNP:771933695
623 623 a, g dbSNP:776762719
624 624 c, t dbSNP:748166713
626 626 c, t dbSNP:147013110
627 627 a, g dbSNP:773277711
629 629 c, t dbSNP:200101076
638 638 -, c dbSNP:387906491
638 638 c, t dbSNP:766873495
640 640 a, c dbSNP:774798326
647 647 a, c dbSNP:760145611
662 662 a, c dbSNP:760125073
664 664 a, c dbSNP:768133135
665 665 a, g dbSNP:752308034
671 671 c, t dbSNP:755554117
675 675 c, g dbSNP:763844854
679 679 g, t dbSNP:753460403
691 691 -, c dbSNP:387906489
696 696 g, t dbSNP:138249749
701 701 c, t dbSNP:778689286
714 714 c, t dbSNP:6639060
717 717 a, c dbSNP:372332800
718 718 c, t dbSNP:758391877
719 719 a, g dbSNP:201127558
731 731 c, t dbSNP:748301023
734 734 a, g dbSNP:143860203
739 739 c, t dbSNP:773295163
740 740 a, g dbSNP:749486136
746 746 c, g dbSNP:771211286
755 755 a, g dbSNP:774922647
756 756 c, t dbSNP:759964053
759 759 -, c dbSNP:387906490
766 766 a, c dbSNP:768186118
767 767 c, t dbSNP:150631365
777 777 c, g dbSNP:775826448
789 789 a, g, t dbSNP:104894734
799 799 a, c dbSNP:139757230
803 803 a, g dbSNP:753327781
808 808 a, g dbSNP:761524591
819 819 c, t dbSNP:764860638
822 822 a, g dbSNP:750270295
825 825 c, g dbSNP:758160581
830 830 c, g dbSNP:779785692
849 849 a, t dbSNP:750108771
850 850 a, g, t dbSNP:372488657
854 854 a, g dbSNP:751302355
861 861 g, t dbSNP:754937993
872 872 a, g dbSNP:781175862
874 874 a, g dbSNP:200715488
875 875 c, t dbSNP:369247345
890 890 a, c dbSNP:373589740
956 956 a, t dbSNP:775957398
976 976 c, t dbSNP:188715671

Target ORF information:

RefSeq Version XM_011545489
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens amelogenin, X-linked (AMELX), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011545489

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT
ATCAATGTTG ACAGGACTGC ATTAGTGCTT ACCCCTTTGA AGTGGTACCA GAGCATAAGG
CCACCGTACC CTTCCTATGG TTACGAGCCC ATGGGTGGAT GGCTGCACCA CCAAATCATC
CCCGTGCTGT CCCAACAGCA CCCCCCGACT CACACCCTGC AGCCTCATCA CCACATCCCA
GTGGTGCCAG CTCAGCAGCC CGTGATCCCC CAGCAACCAA TGATGCCCGT TCCTGGCCAA
CACTCCATGA CTCCAATCCA ACACCACCAG CCAAACCTCC CTCCGCCCGC CCAGCAGCCC
TACCAGCCCC AGCCTGTTCA GCCACAGCCT CACCAGCCCA TGCAGCCCCA GCCACCTGTG
CACCCCATGC AGCCCCTGCC GCCACAGCCA CCTCTGCCTC CGATGTTCCC CATGCAGCCC
CTGCCTCCCA TGCTTCCTGA TCTGACTCTG GAAGCTTGGC CATCAACAGA CAAGACCAAG
CGGGAGGAAG TGGATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25531
Accession Version NM_001142.2
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amelogenin, X isoform isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M86932.1. On Jan 19, 2000 this sequence version replaced gi:4502070. Summary: This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) lacks an in-frame exon in the coding region, compared to variant 3. Isoform 1 is shorter than isoform 3 and is the most abundant isoform of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86932.1, BC074951.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGGTGCTTAC CCCTTTGAAG
TGGTACCAGA GCATAAGGCC ACCGTACCCT TCCTATGGTT ACGAGCCCAT GGGTGGATGG
CTGCACCACC AAATCATCCC CGTGCTGTCC CAACAGCACC CCCCGACTCA CACCCTGCAG
CCTCATCACC ACATCCCAGT GGTGCCAGCT CAGCAGCCCG TGATCCCCCA GCAACCAATG
ATGCCCGTTC CTGGCCAACA CTCCATGACT CCAATCCAAC ACCACCAGCC AAACCTCCCT
CCGCCCGCCC AGCAGCCCTA CCAGCCCCAG CCTGTTCAGC CACAGCCTCA CCAGCCCATG
CAGCCCCAGC CACCTGTGCA CCCCATGCAG CCCCTGCCGC CACAGCCACC TCTGCCTCCG
ATGTTCCCCA TGCAGCCCCT GCCTCCCATG CTTCCTGATC TGACTCTGGA AGCTTGGCCA
TCAACAGACA AGACCAAGCG GGAGGAAGTG GATTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001133.1
CDS69..644
Misc Feature(1)42..44(+)
Misc Feature(2)150..641(+)
Exon (1)1..56
Gene:AMELX
Gene Synonym:
Exon (2)57..122
Gene:AMELX
Gene Synonym:
Exon (3)123..170
Gene:AMELX
Gene Synonym:
Exon (4)171..212
Gene:AMELX
Gene Synonym:
Exon (5)213..638
Gene:AMELX
Gene Synonym:
Exon (6)639..793
Gene:AMELX
Gene Synonym:
Translation
Position Chain Variation Link
62 62 c, t dbSNP:764153884
70 70 c, t dbSNP:104894737
76 76 a, c dbSNP:753863554
79 79 c, g dbSNP:104894738
82 82 -, ttttatttg dbSNP:387906488
86 86 a, g dbSNP:757235287
98 98 c, g dbSNP:780336512
103 103 a, g dbSNP:751652555
118 118 c, t dbSNP:755158864
129 129 c, t dbSNP:776498485
139 139 g, t dbSNP:776551701
146 146 g, t dbSNP:145299463
164 164 c, g dbSNP:745846151
178 178 c, t dbSNP:104894733
181 181 -, c dbSNP:387906487
191 191 c, g dbSNP:765738846
197 197 c, g dbSNP:431825176
199 199 a, g dbSNP:431825177
200 200 a, c dbSNP:431825178
207 207 c, t dbSNP:758813809
211 211 c, t dbSNP:144955572
212 212 a, g dbSNP:149068672
217 217 c, t dbSNP:374272157
223 223 a, g dbSNP:760691566
230 230 c, t dbSNP:368149347
231 231 a, g dbSNP:754022687
234 234 a, c dbSNP:104894736
238 238 c, t dbSNP:761996476
239 239 a, g dbSNP:765687165
240 240 a, g dbSNP:750746199
249 249 c, g dbSNP:758945581
250 250 c, t dbSNP:780365505
255 255 c, g dbSNP:751135700
270 270 a, g dbSNP:371530769
284 284 a, g dbSNP:780818544
286 286 a, c dbSNP:749213434
287 287 c, t dbSNP:2106416
290 290 c, t dbSNP:778441921
292 292 a, c, t dbSNP:148259441
293 293 a, g, t dbSNP:142884100
301 301 a, c dbSNP:768768651
302 302 c, g dbSNP:771775925
323 323 c, t dbSNP:776675035
338 338 a, t dbSNP:762158191
347 347 c, t dbSNP:765306052
348 348 a, g dbSNP:373800800
360 360 a, c dbSNP:763177333
362 362 a, g dbSNP:766939481
366 366 a, g dbSNP:752151612
374 374 c, g, t dbSNP:200842202
375 375 a, g dbSNP:367556910
386 386 a, g dbSNP:755797941
392 392 c, t dbSNP:777235911
401 401 a, t dbSNP:749154172
404 404 a, c dbSNP:756968232
411 411 c, t dbSNP:760321133
412 412 a, c dbSNP:745822682
430 430 c, t dbSNP:771933695
431 431 a, g dbSNP:776762719
432 432 c, t dbSNP:748166713
434 434 c, t dbSNP:147013110
435 435 a, g dbSNP:773277711
437 437 c, t dbSNP:200101076
446 446 -, c dbSNP:387906491
446 446 c, t dbSNP:766873495
448 448 a, c dbSNP:774798326
455 455 a, c dbSNP:760145611
470 470 a, c dbSNP:760125073
472 472 a, c dbSNP:768133135
473 473 a, g dbSNP:752308034
479 479 c, t dbSNP:755554117
483 483 c, g dbSNP:763844854
487 487 g, t dbSNP:753460403
499 499 -, c dbSNP:387906489
504 504 g, t dbSNP:138249749
509 509 c, t dbSNP:778689286
522 522 c, t dbSNP:6639060
525 525 a, c dbSNP:372332800
526 526 c, t dbSNP:758391877
527 527 a, g dbSNP:201127558
539 539 c, t dbSNP:748301023
542 542 a, g dbSNP:143860203
547 547 c, t dbSNP:773295163
548 548 a, g dbSNP:749486136
554 554 c, g dbSNP:771211286
563 563 a, g dbSNP:774922647
564 564 c, t dbSNP:759964053
567 567 -, c dbSNP:387906490
574 574 a, c dbSNP:768186118
575 575 c, t dbSNP:150631365
585 585 c, g dbSNP:775826448
597 597 a, g, t dbSNP:104894734
607 607 a, c dbSNP:139757230
611 611 a, g dbSNP:753327781
616 616 a, g dbSNP:761524591
627 627 c, t dbSNP:764860638
630 630 a, g dbSNP:750270295
633 633 c, g dbSNP:758160581
638 638 c, g dbSNP:779785692
657 657 a, t dbSNP:750108771
658 658 a, g, t dbSNP:372488657
662 662 a, g dbSNP:751302355
669 669 g, t dbSNP:754937993
680 680 a, g dbSNP:781175862
682 682 a, g dbSNP:200715488
683 683 c, t dbSNP:369247345
698 698 a, c dbSNP:373589740
764 764 a, t dbSNP:775957398
784 784 c, t dbSNP:188715671

Target ORF information:

RefSeq Version NM_001142
Organism Homo sapiens (human)
Definition Homo sapiens amelogenin, X-linked (AMELX), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001142

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGGTGCTTAC CCCTTTGAAG
TGGTACCAGA GCATAAGGCC ACCGTACCCT TCCTATGGTT ACGAGCCCAT GGGTGGATGG
CTGCACCACC AAATCATCCC CGTGCTGTCC CAACAGCACC CCCCGACTCA CACCCTGCAG
CCTCATCACC ACATCCCAGT GGTGCCAGCT CAGCAGCCCG TGATCCCCCA GCAACCAATG
ATGCCCGTTC CTGGCCAACA CTCCATGACT CCAATCCAAC ACCACCAGCC AAACCTCCCT
CCGCCCGCCC AGCAGCCCTA CCAGCCCCAG CCTGTTCAGC CACAGCCTCA CCAGCCCATG
CAGCCCCAGC CACCTGTGCA CCCCATGCAG CCCCTGCCGC CACAGCCACC TCTGCCTCCG
ATGTTCCCCA TGCAGCCCCT GCCTCCCATG CTTCCTGATC TGACTCTGGA AGCTTGGCCA
TCAACAGACA AGACCAAGCG GGAGGAAGTG GATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25376
Accession Version NM_182680.1
Sequence Information ORF Nucleotide Sequence (Length: 618bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amelogenin, X isoform isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF436849.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) encodes the longest isoform (3) of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF436849.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2161674, SAMEA962333 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT
ATCAATGTTG ACAGGACTGC ATTAGTGCTT ACCCCTTTGA AGTGGTACCA GAGCATAAGG
CCACCGTACC CTTCCTATGG TTACGAGCCC ATGGGTGGAT GGCTGCACCA CCAAATCATC
CCCGTGCTGT CCCAACAGCA CCCCCCGACT CACACCCTGC AGCCTCATCA CCACATCCCA
GTGGTGCCAG CTCAGCAGCC CGTGATCCCC CAGCAACCAA TGATGCCCGT TCCTGGCCAA
CACTCCATGA CTCCAATCCA ACACCACCAG CCAAACCTCC CTCCGCCCGC CCAGCAGCCC
TACCAGCCCC AGCCTGTTCA GCCACAGCCT CACCAGCCCA TGCAGCCCCA GCCACCTGTG
CACCCCATGC AGCCCCTGCC GCCACAGCCA CCTCTGCCTC CGATGTTCCC CATGCAGCCC
CTGCCTCCCA TGCTTCCTGA TCTGACTCTG GAAGCTTGGC CATCAACAGA CAAGACCAAG
CGGGAGGAAG TGGATTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_872621.1
CDS69..686
Misc Feature(1)42..44(+)
Misc Feature(2)150..683(+)
Exon (1)1..56
Gene:AMELX
Gene Synonym:
Exon (2)57..122
Gene:AMELX
Gene Synonym:
Exon (3)123..170
Gene:AMELX
Gene Synonym:
Exon (4)171..212
Gene:AMELX
Gene Synonym:
Exon (5)213..254
Gene:AMELX
Gene Synonym:
Exon (6)255..680
Gene:AMELX
Gene Synonym:
Exon (7)681..835
Gene:AMELX
Gene Synonym:
Translation
Position Chain Variation Link
62 62 c, t dbSNP:764153884
70 70 c, t dbSNP:104894737
76 76 a, c dbSNP:753863554
79 79 c, g dbSNP:104894738
82 82 -, ttttatttg dbSNP:387906488
86 86 a, g dbSNP:757235287
98 98 c, g dbSNP:780336512
103 103 a, g dbSNP:751652555
118 118 c, t dbSNP:755158864
129 129 c, t dbSNP:776498485
139 139 g, t dbSNP:776551701
146 146 g, t dbSNP:145299463
164 164 c, g dbSNP:745846151
193 193 a, g dbSNP:746714110
220 220 c, t dbSNP:104894733
223 223 -, c dbSNP:387906487
233 233 c, g dbSNP:765738846
239 239 c, g dbSNP:431825176
241 241 a, g dbSNP:431825177
242 242 a, c dbSNP:431825178
249 249 c, t dbSNP:758813809
253 253 c, t dbSNP:144955572
254 254 a, g dbSNP:149068672
259 259 c, t dbSNP:374272157
265 265 a, g dbSNP:760691566
272 272 c, t dbSNP:368149347
273 273 a, g dbSNP:754022687
276 276 a, c dbSNP:104894736
280 280 c, t dbSNP:761996476
281 281 a, g dbSNP:765687165
282 282 a, g dbSNP:750746199
291 291 c, g dbSNP:758945581
292 292 c, t dbSNP:780365505
297 297 c, g dbSNP:751135700
312 312 a, g dbSNP:371530769
326 326 a, g dbSNP:780818544
328 328 a, c dbSNP:749213434
329 329 c, t dbSNP:2106416
332 332 c, t dbSNP:778441921
334 334 a, c, t dbSNP:148259441
335 335 a, g, t dbSNP:142884100
343 343 a, c dbSNP:768768651
344 344 c, g dbSNP:771775925
365 365 c, t dbSNP:776675035
380 380 a, t dbSNP:762158191
389 389 c, t dbSNP:765306052
390 390 a, g dbSNP:373800800
402 402 a, c dbSNP:763177333
404 404 a, g dbSNP:766939481
408 408 a, g dbSNP:752151612
416 416 c, g, t dbSNP:200842202
417 417 a, g dbSNP:367556910
428 428 a, g dbSNP:755797941
434 434 c, t dbSNP:777235911
443 443 a, t dbSNP:749154172
446 446 a, c dbSNP:756968232
453 453 c, t dbSNP:760321133
454 454 a, c dbSNP:745822682
472 472 c, t dbSNP:771933695
473 473 a, g dbSNP:776762719
474 474 c, t dbSNP:748166713
476 476 c, t dbSNP:147013110
477 477 a, g dbSNP:773277711
479 479 c, t dbSNP:200101076
488 488 -, c dbSNP:387906491
488 488 c, t dbSNP:766873495
490 490 a, c dbSNP:774798326
497 497 a, c dbSNP:760145611
512 512 a, c dbSNP:760125073
514 514 a, c dbSNP:768133135
515 515 a, g dbSNP:752308034
521 521 c, t dbSNP:755554117
525 525 c, g dbSNP:763844854
529 529 g, t dbSNP:753460403
541 541 -, c dbSNP:387906489
546 546 g, t dbSNP:138249749
551 551 c, t dbSNP:778689286
564 564 c, t dbSNP:6639060
567 567 a, c dbSNP:372332800
568 568 c, t dbSNP:758391877
569 569 a, g dbSNP:201127558
581 581 c, t dbSNP:748301023
584 584 a, g dbSNP:143860203
589 589 c, t dbSNP:773295163
590 590 a, g dbSNP:749486136
596 596 c, g dbSNP:771211286
605 605 a, g dbSNP:774922647
606 606 c, t dbSNP:759964053
609 609 -, c dbSNP:387906490
616 616 a, c dbSNP:768186118
617 617 c, t dbSNP:150631365
627 627 c, g dbSNP:775826448
639 639 a, g, t dbSNP:104894734
649 649 a, c dbSNP:139757230
653 653 a, g dbSNP:753327781
658 658 a, g dbSNP:761524591
669 669 c, t dbSNP:764860638
672 672 a, g dbSNP:750270295
675 675 c, g dbSNP:758160581
680 680 c, g dbSNP:779785692
699 699 a, t dbSNP:750108771
700 700 a, g, t dbSNP:372488657
704 704 a, g dbSNP:751302355
711 711 g, t dbSNP:754937993
722 722 a, g dbSNP:781175862
724 724 a, g dbSNP:200715488
725 725 c, t dbSNP:369247345
740 740 a, c dbSNP:373589740
806 806 a, t dbSNP:775957398
826 826 c, t dbSNP:188715671

Target ORF information:

RefSeq Version NM_182680
Organism Homo sapiens (human)
Definition Homo sapiens amelogenin, X-linked (AMELX), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_182680

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTCTACCA 
CCTCATCCTG GGCACCCTGG TTATATCAAC TTCAGCTATG AGAACTCACA TTCTCAGGCT
ATCAATGTTG ACAGGACTGC ATTAGTGCTT ACCCCTTTGA AGTGGTACCA GAGCATAAGG
CCACCGTACC CTTCCTATGG TTACGAGCCC ATGGGTGGAT GGCTGCACCA CCAAATCATC
CCCGTGCTGT CCCAACAGCA CCCCCCGACT CACACCCTGC AGCCTCATCA CCACATCCCA
GTGGTGCCAG CTCAGCAGCC CGTGATCCCC CAGCAACCAA TGATGCCCGT TCCTGGCCAA
CACTCCATGA CTCCAATCCA ACACCACCAG CCAAACCTCC CTCCGCCCGC CCAGCAGCCC
TACCAGCCCC AGCCTGTTCA GCCACAGCCT CACCAGCCCA TGCAGCCCCA GCCACCTGTG
CACCCCATGC AGCCCCTGCC GCCACAGCCA CCTCTGCCTC CGATGTTCCC CATGCAGCCC
CTGCCTCCCA TGCTTCCTGA TCTGACTCTG GAAGCTTGGC CATCAACAGA CAAGACCAAG
CGGGAGGAAG TGGATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25363
Accession Version NM_182681.1
Sequence Information ORF Nucleotide Sequence (Length: 528bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amelogenin, X isoform isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M86932.1. Summary: This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 3. Isoform 2 is shorter than isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86932.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTGTGCTT 
ACCCCTTTGA AGTGGTACCA GAGCATAAGG CCACCGTACC CTTCCTATGG TTACGAGCCC
ATGGGTGGAT GGCTGCACCA CCAAATCATC CCCGTGCTGT CCCAACAGCA CCCCCCGACT
CACACCCTGC AGCCTCATCA CCACATCCCA GTGGTGCCAG CTCAGCAGCC CGTGATCCCC
CAGCAACCAA TGATGCCCGT TCCTGGCCAA CACTCCATGA CTCCAATCCA ACACCACCAG
CCAAACCTCC CTCCGCCCGC CCAGCAGCCC TACCAGCCCC AGCCTGTTCA GCCACAGCCT
CACCAGCCCA TGCAGCCCCA GCCACCTGTG CACCCCATGC AGCCCCTGCC GCCACAGCCA
CCTCTGCCTC CGATGTTCCC CATGCAGCCC CTGCCTCCCA TGCTTCCTGA TCTGACTCTG
GAAGCTTGGC CATCAACAGA CAAGACCAAG CGGGAGGAAG TGGATTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_872622.1
CDS69..596
Misc Feature(1)42..44(+)
Misc Feature(2)111..593(+)
Exon (1)1..56
Gene:AMELX
Gene Synonym:
Exon (2)57..122
Gene:AMELX
Gene Synonym:
Exon (3)123..164
Gene:AMELX
Gene Synonym:
Exon (4)165..590
Gene:AMELX
Gene Synonym:
Exon (5)591..745
Gene:AMELX
Gene Synonym:
Translation
Position Chain Variation Link
62 62 c, t dbSNP:764153884
70 70 c, t dbSNP:104894737
76 76 a, c dbSNP:753863554
79 79 c, g dbSNP:104894738
82 82 -, ttttatttg dbSNP:387906488
86 86 a, g dbSNP:757235287
98 98 c, g dbSNP:780336512
103 103 a, g dbSNP:751652555
118 118 c, t dbSNP:755158864
130 130 c, t dbSNP:104894733
133 133 -, c dbSNP:387906487
143 143 c, g dbSNP:765738846
149 149 c, g dbSNP:431825176
151 151 a, g dbSNP:431825177
152 152 a, c dbSNP:431825178
159 159 c, t dbSNP:758813809
163 163 c, t dbSNP:144955572
164 164 a, g dbSNP:149068672
169 169 c, t dbSNP:374272157
175 175 a, g dbSNP:760691566
182 182 c, t dbSNP:368149347
183 183 a, g dbSNP:754022687
186 186 a, c dbSNP:104894736
190 190 c, t dbSNP:761996476
191 191 a, g dbSNP:765687165
192 192 a, g dbSNP:750746199
201 201 c, g dbSNP:758945581
202 202 c, t dbSNP:780365505
207 207 c, g dbSNP:751135700
222 222 a, g dbSNP:371530769
236 236 a, g dbSNP:780818544
238 238 a, c dbSNP:749213434
239 239 c, t dbSNP:2106416
242 242 c, t dbSNP:778441921
244 244 a, c, t dbSNP:148259441
245 245 a, g, t dbSNP:142884100
253 253 a, c dbSNP:768768651
254 254 c, g dbSNP:771775925
275 275 c, t dbSNP:776675035
290 290 a, t dbSNP:762158191
299 299 c, t dbSNP:765306052
300 300 a, g dbSNP:373800800
312 312 a, c dbSNP:763177333
314 314 a, g dbSNP:766939481
318 318 a, g dbSNP:752151612
326 326 c, g, t dbSNP:200842202
327 327 a, g dbSNP:367556910
338 338 a, g dbSNP:755797941
344 344 c, t dbSNP:777235911
353 353 a, t dbSNP:749154172
356 356 a, c dbSNP:756968232
363 363 c, t dbSNP:760321133
364 364 a, c dbSNP:745822682
382 382 c, t dbSNP:771933695
383 383 a, g dbSNP:776762719
384 384 c, t dbSNP:748166713
386 386 c, t dbSNP:147013110
387 387 a, g dbSNP:773277711
389 389 c, t dbSNP:200101076
398 398 -, c dbSNP:387906491
398 398 c, t dbSNP:766873495
400 400 a, c dbSNP:774798326
407 407 a, c dbSNP:760145611
422 422 a, c dbSNP:760125073
424 424 a, c dbSNP:768133135
425 425 a, g dbSNP:752308034
431 431 c, t dbSNP:755554117
435 435 c, g dbSNP:763844854
439 439 g, t dbSNP:753460403
451 451 -, c dbSNP:387906489
456 456 g, t dbSNP:138249749
461 461 c, t dbSNP:778689286
474 474 c, t dbSNP:6639060
477 477 a, c dbSNP:372332800
478 478 c, t dbSNP:758391877
479 479 a, g dbSNP:201127558
491 491 c, t dbSNP:748301023
494 494 a, g dbSNP:143860203
499 499 c, t dbSNP:773295163
500 500 a, g dbSNP:749486136
506 506 c, g dbSNP:771211286
515 515 a, g dbSNP:774922647
516 516 c, t dbSNP:759964053
519 519 -, c dbSNP:387906490
526 526 a, c dbSNP:768186118
527 527 c, t dbSNP:150631365
537 537 c, g dbSNP:775826448
549 549 a, g, t dbSNP:104894734
559 559 a, c dbSNP:139757230
563 563 a, g dbSNP:753327781
568 568 a, g dbSNP:761524591
579 579 c, t dbSNP:764860638
582 582 a, g dbSNP:750270295
585 585 c, g dbSNP:758160581
590 590 c, g dbSNP:779785692
609 609 a, t dbSNP:750108771
610 610 a, g, t dbSNP:372488657
614 614 a, g dbSNP:751302355
621 621 g, t dbSNP:754937993
632 632 a, g dbSNP:781175862
634 634 a, g dbSNP:200715488
635 635 c, t dbSNP:369247345
650 650 a, c dbSNP:373589740
716 716 a, t dbSNP:775957398
736 736 c, t dbSNP:188715671

Target ORF information:

RefSeq Version NM_182681
Organism Homo sapiens (human)
Definition Homo sapiens amelogenin, X-linked (AMELX), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_182681

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGGGACCT GGATTTTATT TGCCTGCCTC CTGGGAGCAG CTTTTGCCAT GCCTGTGCTT 
ACCCCTTTGA AGTGGTACCA GAGCATAAGG CCACCGTACC CTTCCTATGG TTACGAGCCC
ATGGGTGGAT GGCTGCACCA CCAAATCATC CCCGTGCTGT CCCAACAGCA CCCCCCGACT
CACACCCTGC AGCCTCATCA CCACATCCCA GTGGTGCCAG CTCAGCAGCC CGTGATCCCC
CAGCAACCAA TGATGCCCGT TCCTGGCCAA CACTCCATGA CTCCAATCCA ACACCACCAG
CCAAACCTCC CTCCGCCCGC CCAGCAGCCC TACCAGCCCC AGCCTGTTCA GCCACAGCCT
CACCAGCCCA TGCAGCCCCA GCCACCTGTG CACCCCATGC AGCCCCTGCC GCCACAGCCA
CCTCTGCCTC CGATGTTCCC CATGCAGCCC CTGCCTCCCA TGCTTCCTGA TCTGACTCTG
GAAGCTTGGC CATCAACAGA CAAGACCAAG CGGGAGGAAG TGGATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.