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HEYL hes-related family bHLH transcription factor with YRPW motif-like [Homo sapiens (human)]

Gene Symbol HEYL
Entrez Gene ID 26508
Full Name hes-related family bHLH transcription factor with YRPW motif-like
Synonyms HESR3, HEY3, HRT3, bHLHb33
General protein information
Preferred Names
hairy/enhancer-of-split related with YRPW motif-like protein
Names
hairy/enhancer-of-split related with YRPW motif-like protein
HRT-3
hHRT3
hHeyL
HEY-like protein
hairy-related transcription factor 3
class B basic helix-loop-helix protein 33
hairy/enhancer-of-split related with YRPW motif 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p34.3

Summary This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

609034

Disorder Html:





The following HEYL gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEYL gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu33344 XM_005270745 PREDICTED: Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199
OHu06538 NM_014571 Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.3
$309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu33344
Accession Version XM_005270745.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 903bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product hairy/enhancer-of-split related with YRPW motif-like protein isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_032977.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530362370. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC
TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005270802.1
CDS190..1092
Misc Feature(1)229..405(+)
Misc Feature(2)232..357(+)
Misc Feature(3)259..261(+)
Misc Feature(4)277..402(+)
Misc Feature(5)448..591(+)
Translation
Position Chain Variation Link
111 111 a, c dbSNP:565360331
145 145 a, c dbSNP:142989794
157 157 a, g dbSNP:538357393
193 193 a, g dbSNP:368236989
196 196 a, g dbSNP:759277385
200 200 c, t dbSNP:757565243
209 209 a, c, g dbSNP:771106304
211 211 c, g dbSNP:181674145
213 213 -, c dbSNP:760374440
222 222 a, g dbSNP:763202732
226 226 a, g dbSNP:773344582
227 227 g, t dbSNP:769850441
231 231 a, g dbSNP:748160359
234 234 c, t dbSNP:550732507
239 239 a, g dbSNP:769157772
245 245 a, g dbSNP:784625
248 248 c, g dbSNP:574593348
255 255 a, c dbSNP:201520391
258 258 a, g dbSNP:769086936
265 265 c, t dbSNP:139605272
266 266 a, g dbSNP:775779178
268 268 c, t dbSNP:772502405
271 271 c, t dbSNP:139786829
272 272 a, g dbSNP:777598242
275 275 a, t dbSNP:755774767
277 277 c, t dbSNP:747706788
278 278 a, g dbSNP:141413445
296 296 c, t dbSNP:754936352
304 304 c, t dbSNP:751498805
307 307 c, t dbSNP:766168978
308 308 a, g dbSNP:143373894
322 322 a, g dbSNP:555240790
328 328 a, g dbSNP:765492005
330 330 c, g dbSNP:745657046
336 336 c, g dbSNP:761992572
351 351 a, g dbSNP:768184067
360 360 c, t dbSNP:760084644
361 361 a, g dbSNP:774922728
370 370 c, t dbSNP:771409504
377 377 c, t dbSNP:200560318
378 378 a, g dbSNP:776350380
381 381 a, g dbSNP:138290900
391 391 a, g dbSNP:746579964
404 404 c, g dbSNP:779399970
407 407 c, t dbSNP:376207364
408 408 g, t dbSNP:372879677
409 409 g, t dbSNP:375912663
410 410 a, g dbSNP:138456992
418 418 g, t dbSNP:753540092
427 427 c, g dbSNP:780806225
432 432 c, t dbSNP:781505418
433 433 c, g, t dbSNP:751649234
434 434 a, g dbSNP:767043194
438 438 c, t dbSNP:758801120
452 452 c, t dbSNP:750868509
454 454 c, t dbSNP:34926922
455 455 a, g dbSNP:141784681
457 457 a, g dbSNP:775130030
459 459 c, g dbSNP:754649134
461 461 c, t dbSNP:759071848
464 464 a, g dbSNP:773824823
467 467 a, t dbSNP:770937076
469 469 c, t dbSNP:749174750
470 470 a, g dbSNP:773114404
487 487 a, g dbSNP:140082325
493 493 a, g dbSNP:747884899
495 495 g, t dbSNP:781595560
498 498 c, t dbSNP:369111124
499 499 c, t dbSNP:747126799
500 500 g, t dbSNP:780279101
504 504 a, g dbSNP:759002874
507 507 a, c dbSNP:750910133
512 512 a, t dbSNP:765711535
514 514 a, g dbSNP:757597602
516 516 g, t dbSNP:754157225
517 517 c, t dbSNP:377284150
519 519 c, t dbSNP:569637846
525 525 c, t dbSNP:759153481
526 526 c, t dbSNP:773914888
537 537 c, t dbSNP:765789947
538 538 a, g dbSNP:762466594
541 541 c, t dbSNP:199883985
542 542 a, g, t dbSNP:367972512
547 547 c, t dbSNP:747977443
551 551 g, t dbSNP:776537445
556 556 c, t dbSNP:79211072
560 560 a, t dbSNP:769066770
564 564 c, g dbSNP:151145306
565 565 a, c dbSNP:758881317
573 573 c, t dbSNP:41264505
574 574 a, g dbSNP:139355861
577 577 a, g dbSNP:187780653
578 578 c, t dbSNP:149801578
579 579 c, t dbSNP:372712511
580 580 a, g dbSNP:757763641
584 584 c, t dbSNP:754237272
588 588 c, g dbSNP:778102766
589 589 c, g dbSNP:754681050
593 593 c, t dbSNP:139668981
594 594 a, g, t dbSNP:371911261
595 595 c, t dbSNP:749899115
599 599 c, t dbSNP:368302386
600 600 a, g dbSNP:41264503
601 601 a, c, t dbSNP:768586554
603 603 c, t dbSNP:760482982
604 604 a, g dbSNP:750393357
610 610 c, t dbSNP:772292386
612 612 c, t dbSNP:745987902
621 621 c, t dbSNP:765069844
622 622 c, t dbSNP:143476012
634 634 g, t dbSNP:375464241
636 636 a, g, t dbSNP:138365730
639 639 c, t dbSNP:113617017
640 640 c, t dbSNP:1180318
641 641 c, t dbSNP:753064125
647 647 a, g dbSNP:533557688
657 657 a, t dbSNP:564488541
668 668 c, t dbSNP:140829574
679 679 c, t dbSNP:267598593
685 685 a, g dbSNP:753971979
690 690 a, c, g dbSNP:146516387
693 693 a, g dbSNP:753832825
699 699 a, g, t dbSNP:374656603
700 700 c, g dbSNP:370285415
704 704 c, g, t dbSNP:772226518
709 709 c, g dbSNP:759795912
711 711 c, t dbSNP:774348910
717 717 c, g, t dbSNP:115716116
718 718 c, t dbSNP:778282702
720 720 c, t dbSNP:371317210
721 721 g, t dbSNP:115068989
725 725 c, t dbSNP:772073154
736 736 a, g dbSNP:199627999
737 737 c, g dbSNP:112803927
749 749 c, g dbSNP:778643736
752 752 a, c dbSNP:756861621
757 757 c, t dbSNP:753352796
758 758 a, g dbSNP:764180477
762 762 c, t dbSNP:756052085
763 763 a, g dbSNP:752497647
772 772 c, t dbSNP:767327706
773 773 a, c, g, t dbSNP:766546094
783 783 a, c dbSNP:763041211
793 793 c, t dbSNP:773253750
802 802 c, t dbSNP:374807919
803 803 a, g dbSNP:372916805
807 807 a, g dbSNP:78932473
823 823 c, t dbSNP:769070110
839 839 c, t dbSNP:747298126
841 841 c, t dbSNP:778733690
850 850 c, t dbSNP:756951380
851 851 a, g dbSNP:748851931
864 864 a, g dbSNP:375295630
874 874 c, t dbSNP:372340302
885 885 c, t dbSNP:559775469
886 886 a, g dbSNP:752690094
890 890 c, t dbSNP:201840029
899 899 a, g dbSNP:200662775
904 904 c, g dbSNP:1737738
905 905 c, g dbSNP:1737737
918 918 c, t dbSNP:751304032
920 920 c, t dbSNP:370502372
921 921 c, t dbSNP:766635894
922 922 g, t dbSNP:576981180
926 926 a, c dbSNP:773346563
930 930 c, t dbSNP:267598592
934 934 c, t dbSNP:765315524
942 942 c, t dbSNP:749644621
945 945 c, g dbSNP:200236163
959 959 g, t dbSNP:768998658
967 967 a, g, t dbSNP:775969852
971 971 c, g, t dbSNP:201157311
972 972 a, g dbSNP:777506480
979 979 g, t dbSNP:769348003
984 984 a, g dbSNP:201707555
988 988 -, g dbSNP:368717907
993 993 -, c dbSNP:771597427
998 998 c, g, t dbSNP:377079448
1026 1026 a, g dbSNP:554192451
1028 1028 a, g dbSNP:754847437
1031 1031 c, t dbSNP:751395824
1033 1033 g, t dbSNP:534299990
1034 1034 c, g, t dbSNP:199521829
1042 1042 a, g dbSNP:765338498
1044 1044 a, g dbSNP:139544750
1057 1057 g, t dbSNP:753842517
1060 1060 g, t dbSNP:558635363
1063 1063 g, t dbSNP:764705377
1074 1074 -, tgaaatcgg dbSNP:749770548
1074 1074 g, t dbSNP:371583375
1081 1081 a, g dbSNP:776059831
1099 1099 c, g dbSNP:772575144
1103 1103 c, t dbSNP:764222546
1105 1105 c, t dbSNP:183890301
1108 1108 c, t dbSNP:191371215
1111 1111 c, t dbSNP:759910471
1116 1116 c, t dbSNP:150591457
1158 1158 a, g dbSNP:550856748
1159 1159 c, t dbSNP:531270507
1178 1178 c, t dbSNP:527386529
1182 1182 a, c, g dbSNP:2695320
1187 1187 c, g dbSNP:750013021
1227 1227 a, c dbSNP:528479111
1229 1229 c, t dbSNP:765261851
1247 1247 c, t dbSNP:559450152
1266 1266 a, t dbSNP:115608339
1269 1269 c, t dbSNP:143702140
1278 1278 c, t dbSNP:188142662
1333 1333 c, t dbSNP:548817491
1340 1340 a, g dbSNP:183266275
1359 1359 c, g dbSNP:574422527
1370 1370 g, t dbSNP:554431129
1384 1384 c, t dbSNP:540895508
1416 1416 c, g dbSNP:41264501
1441 1441 c, g dbSNP:558220549
1451 1451 -, accagg dbSNP:2307917
1454 1454 -, aggacc dbSNP:201450931
1482 1482 c, t dbSNP:552280913
1505 1505 a, g dbSNP:538737122
1514 1514 g, t dbSNP:569642442
1520 1520 c, t dbSNP:753664881
1532 1532 a, g dbSNP:376779376
1562 1562 a, g dbSNP:763815500
1581 1581 g, t dbSNP:557578449
1608 1608 -, g dbSNP:137911802
1615 1615 c, g dbSNP:190993934
1657 1657 a, c dbSNP:563024194
1680 1680 c, t dbSNP:375847567
1737 1737 c, t dbSNP:755620716
1809 1809 c, t dbSNP:760908899
1823 1823 c, g dbSNP:775579059
1840 1840 -, tg dbSNP:771391854
1887 1887 a, g dbSNP:568805127
1903 1903 c, t dbSNP:767575178
1919 1919 a, c dbSNP:147241011
1932 1932 c, t dbSNP:759594991
1933 1933 a, g dbSNP:774475980
1938 1938 c, t dbSNP:528765186
1954 1954 a, c dbSNP:188708237
1957 1957 a, t dbSNP:552246769
1958 1958 c, t dbSNP:559685317
1964 1964 g, t dbSNP:771393922
1987 1987 a, g dbSNP:749839999
2005 2005 a, g dbSNP:532688278
2017 2017 a, g dbSNP:376278740
2059 2059 g, t dbSNP:549601918
2064 2064 c, t dbSNP:143934134
2080 2080 g, t dbSNP:560722152
2084 2084 a, g dbSNP:148112227
2152 2152 c, t dbSNP:11206478
2153 2153 c, g dbSNP:564937424
2243 2243 a, g dbSNP:544674309
2246 2246 a, g dbSNP:576115030
2255 2255 c, t dbSNP:560538573
2256 2256 c, t dbSNP:182773043
2257 2257 c, t dbSNP:536317655
2311 2311 a, g dbSNP:575104511
2338 2338 c, t dbSNP:767088418
2342 2342 c, t dbSNP:117679560
2372 2372 c, t dbSNP:540325312
2373 2373 g, t dbSNP:12049221
2421 2421 c, g dbSNP:566231366
2425 2425 a, c dbSNP:778617301
2433 2433 c, t dbSNP:143683714
2447 2447 c, t dbSNP:552571643
2451 2451 g, t dbSNP:538642690
2459 2459 c, g dbSNP:148982776
2466 2466 c, g dbSNP:41264499
2495 2495 a, g dbSNP:530089320
2518 2518 a, g dbSNP:138871678
2519 2519 a, g dbSNP:777557147
2526 2526 -, gttca dbSNP:750193277
2639 2639 a, g dbSNP:547181648
2685 2685 -, g dbSNP:766204608
2703 2703 a, g dbSNP:527632820
2721 2721 c, t dbSNP:755874286
2729 2729 c, t dbSNP:565009299
2760 2760 g, t dbSNP:545021876
2761 2761 c, t dbSNP:575964222
2771 2771 g, t dbSNP:562437127
2792 2792 c, g dbSNP:372407957
2830 2830 c, t dbSNP:752592131
2849 2849 c, t dbSNP:41264497
2862 2862 a, g dbSNP:535251181
2863 2863 a, g dbSNP:575868941
2871 2871 a, g dbSNP:555240800
2895 2895 a, t dbSNP:534886445
2911 2911 a, g dbSNP:190986521
2927 2927 c, g dbSNP:559005718
2940 2940 a, c dbSNP:543421470
2968 2968 a, g dbSNP:539294029
3020 3020 c, t dbSNP:772082951
3036 3036 a, c dbSNP:539771599
3097 3097 a, g dbSNP:186178580
3110 3110 c, g dbSNP:569718016
3164 3164 c, t dbSNP:745811962
3169 3169 a, g dbSNP:549724585
3188 3188 c, t dbSNP:536388733
3196 3196 c, g dbSNP:778818220
3198 3198 a, g dbSNP:375034027
3219 3219 c, t dbSNP:11554176
3228 3228 g, t dbSNP:41264495
3256 3256 a, c dbSNP:763387335
3265 3265 g, t dbSNP:547216509
3272 3272 c, t dbSNP:41264493
3279 3279 c, t dbSNP:41264491
3296 3296 c, g dbSNP:375071116
3326 3326 c, t dbSNP:6587
3345 3345 c, t dbSNP:548338263
3354 3354 c, g dbSNP:531584592
3409 3409 c, t dbSNP:78706896
3410 3410 a, g dbSNP:542633090
3500 3500 g, t dbSNP:180995630
3524 3524 c, t dbSNP:529043487
3539 3539 a, c dbSNP:560276047
3563 3563 a, g dbSNP:540291443
3570 3570 c, t dbSNP:771830719
3601 3601 c, g dbSNP:140314362
3603 3603 c, g dbSNP:752337633
3629 3629 c, t dbSNP:559065410
3635 3635 c, g dbSNP:545387557
3647 3647 a, g dbSNP:531931512
3671 3671 c, g dbSNP:576319266
3673 3673 a, g dbSNP:745539827
3676 3676 a, g dbSNP:12030495
3682 3682 a, c dbSNP:770567619
3708 3708 c, t dbSNP:2695321
3727 3727 c, t dbSNP:200913639
3729 3729 a, c dbSNP:552545622
3781 3781 c, t dbSNP:151170453
3795 3795 a, t dbSNP:534271665
3802 3802 a, g dbSNP:756140334
3812 3812 c, g dbSNP:142093126
3846 3846 a, c dbSNP:116401702
3863 3863 a, c dbSNP:114297514
3901 3901 a, c dbSNP:12022423
3906 3906 c, t dbSNP:765821510
3910 3910 a, g dbSNP:755140248
3915 3915 a, g dbSNP:372439881
3946 3946 a, g dbSNP:549035554
3952 3952 a, c, t dbSNP:528912772
3954 3954 a, g dbSNP:560162992
3986 3986 c, g dbSNP:539955756
4006 4006 a, t dbSNP:533007649
4018 4018 c, t dbSNP:762933616
4059 4059 a, t dbSNP:565382100
4116 4116 a, g dbSNP:189693750
4122 4122 a, g dbSNP:765632241

Target ORF information:

RefSeq Version XM_005270745
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005270745

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCAGGC CGCTGTCCAC CCCCAGCTCT TCGCAGATGC AAGCCAGGAA GAAACACAGA 
GGGATCATAG AGAAACGGCG TCGAGACCGC ATCAACAGTA GCCTTTCTGA ATTGCGACGC
TTGGTCCCCA CTGCCTTTGA GAAACAGGGC TCTTCCAAGC TGGAGAAAGC CGAGGTCTTG
CAGATGACGG TGGATCACTT GAAAATGCTC CATGCCACTG GTGGGACAGG ATTCTTTGAT
GCCCGAGCCC TGGCAGTTGA CTTCCGGAGC ATTGGTTTTC GGGAGTGCCT CACTGAGGTC
ATCAGGTACC TGGGGGTCCT TGAAGGGCCC AGCAGCCGTG CAGACCCCGT CCGGATTCGC
CTTCTCTCCC ACCTCAACAG CTACGCAGCC GAGATGGAGC CTTCGCCCAC GCCCACTGGC
CCTTTGGCCT TCCCTGCCTG GCCCTGGTCT TTCTTCCATA GCTGTCCAGG GCTGCCAGCC
CTGAGCAACC AGCTCGCCAT CCTGGGAAGA GTGCCCAGCC CTGTCCTCCC CGGTGTCTCC
TCTCCTGCTT ACCCCATCCC AGCCCTCCGA ACCGCTCCCC TTCGCAGAGC CACAGGCATC
ATCCTGCCAG CCCGGAGGAA TGTGCTGCCC AGTCGAGGGG CATCTTCCAC CCGGAGGGCC
CGCCCCCTAG AGAGGCCAGC GACCCCTGTG CCTGTCGCCC CCAGCAGCAG GGCTGCCAGG
AGCAGCCACA TCGCTCCCCT CCTGCAGTCT TCCTCCCCAA CACCCCCTGG TCCTACAGGG
TCGGCTGCTT ACGTGGCTGT TCCCACCCCC AACTCATCCT CCCCAGGGCC AGCTGGGAGG
CCAGCGGGAG CCATGCTCTA CCACTCCTGG GTCTCTGAAA TCACTGAAAT CGGGGCTTTC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu06538
Accession Version NM_014571.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 987bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product hairy/enhancer-of-split related with YRPW motif-like protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL541019.3, BC006087.1, AL035404.20 and BM682076.1. On Jun 1, 2006 this sequence version replaced gi:19923414. Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL541019.3, BC006087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG
ATGCAAGCCA GGAAGAAACG CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT
GAAATCACTG AAATCGGGGC TTTCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_055386.1
CDS52..1038
Misc Feature(1)175..384(+)
Misc Feature(2)181..351(+)
Misc Feature(3)181..303(+)
Misc Feature(4)205..207(+)
Misc Feature(5)223..348(+)
Misc Feature(6)394..537(+)
Exon (1)1..131
Gene:HEYL
Gene Synonym:
Exon (2)132..198
Gene:HEYL
Gene Synonym:
Exon (3)199..282
Gene:HEYL
Gene Synonym:
Exon (4)283..364
Gene:HEYL
Gene Synonym:
Exon (5)365..4114
Gene:HEYL
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, g dbSNP:772547993
5 5 c, t dbSNP:769817131
7 7 a, g dbSNP:534937353
9 9 g, t dbSNP:781101653
10 10 a, c dbSNP:768586532
12 12 c, t dbSNP:746734694
16 16 a, c dbSNP:780454931
20 20 a, g dbSNP:758648994
22 22 a, g, t dbSNP:778830916
23 23 a, g dbSNP:566289252
27 27 c, t dbSNP:754283313
31 31 a, g dbSNP:764600171
36 36 a, g dbSNP:756470797
38 38 a, g dbSNP:753019861
41 41 c, g dbSNP:766041948
49 49 c, g dbSNP:762569509
52 52 a, g dbSNP:201783171
53 53 g, t dbSNP:764641613
54 54 a, g dbSNP:761330653
64 64 a, g dbSNP:200352226
65 65 a, g dbSNP:768674465
69 69 a, g dbSNP:746826610
70 70 a, c dbSNP:373227169
75 75 a, c, g, t dbSNP:563966276
101 101 a, c dbSNP:757295233
103 103 a, g dbSNP:749319380
106 106 a, g dbSNP:370029829
112 112 a, g dbSNP:756564626
120 120 c, g dbSNP:753109580
129 129 a, g dbSNP:139547686
139 139 a, g dbSNP:368236989
142 142 a, g dbSNP:759277385
146 146 c, t dbSNP:757565243
155 155 a, c, g dbSNP:771106304
157 157 c, g dbSNP:181674145
159 159 -, c dbSNP:760374440
168 168 a, g dbSNP:763202732
172 172 a, g dbSNP:773344582
173 173 g, t dbSNP:769850441
177 177 a, g dbSNP:748160359
180 180 c, t dbSNP:550732507
185 185 a, g dbSNP:769157772
191 191 a, g dbSNP:784625
194 194 c, g dbSNP:574593348
201 201 a, c dbSNP:201520391
204 204 a, g dbSNP:769086936
211 211 c, t dbSNP:139605272
212 212 a, g dbSNP:775779178
214 214 c, t dbSNP:772502405
217 217 c, t dbSNP:139786829
218 218 a, g dbSNP:777598242
221 221 a, t dbSNP:755774767
223 223 c, t dbSNP:747706788
224 224 a, g dbSNP:141413445
242 242 c, t dbSNP:754936352
250 250 c, t dbSNP:751498805
253 253 c, t dbSNP:766168978
254 254 a, g dbSNP:143373894
268 268 a, g dbSNP:555240790
274 274 a, g dbSNP:765492005
276 276 c, g dbSNP:745657046
282 282 c, g dbSNP:761992572
297 297 a, g dbSNP:768184067
306 306 c, t dbSNP:760084644
307 307 a, g dbSNP:774922728
316 316 c, t dbSNP:771409504
323 323 c, t dbSNP:200560318
324 324 a, g dbSNP:776350380
327 327 a, g dbSNP:138290900
337 337 a, g dbSNP:746579964
350 350 c, g dbSNP:779399970
353 353 c, t dbSNP:376207364
354 354 g, t dbSNP:372879677
355 355 g, t dbSNP:375912663
356 356 a, g dbSNP:138456992
364 364 g, t dbSNP:753540092
373 373 c, g dbSNP:780806225
378 378 c, t dbSNP:781505418
379 379 c, g, t dbSNP:751649234
380 380 a, g dbSNP:767043194
384 384 c, t dbSNP:758801120
398 398 c, t dbSNP:750868509
400 400 c, t dbSNP:34926922
401 401 a, g dbSNP:141784681
403 403 a, g dbSNP:775130030
405 405 c, g dbSNP:754649134
407 407 c, t dbSNP:759071848
410 410 a, g dbSNP:773824823
413 413 a, t dbSNP:770937076
415 415 c, t dbSNP:749174750
416 416 a, g dbSNP:773114404
433 433 a, g dbSNP:140082325
439 439 a, g dbSNP:747884899
441 441 g, t dbSNP:781595560
444 444 c, t dbSNP:369111124
445 445 c, t dbSNP:747126799
446 446 g, t dbSNP:780279101
450 450 a, g dbSNP:759002874
453 453 a, c dbSNP:750910133
458 458 a, t dbSNP:765711535
460 460 a, g dbSNP:757597602
462 462 g, t dbSNP:754157225
463 463 c, t dbSNP:377284150
465 465 c, t dbSNP:569637846
471 471 c, t dbSNP:759153481
472 472 c, t dbSNP:773914888
483 483 c, t dbSNP:765789947
484 484 a, g dbSNP:762466594
487 487 c, t dbSNP:199883985
488 488 a, g, t dbSNP:367972512
493 493 c, t dbSNP:747977443
497 497 g, t dbSNP:776537445
502 502 c, t dbSNP:79211072
506 506 a, t dbSNP:769066770
510 510 c, g dbSNP:151145306
511 511 a, c dbSNP:758881317
519 519 c, t dbSNP:41264505
520 520 a, g dbSNP:139355861
523 523 a, g dbSNP:187780653
524 524 c, t dbSNP:149801578
525 525 c, t dbSNP:372712511
526 526 a, g dbSNP:757763641
530 530 c, t dbSNP:754237272
534 534 c, g dbSNP:778102766
535 535 c, g dbSNP:754681050
539 539 c, t dbSNP:139668981
540 540 a, g, t dbSNP:371911261
541 541 c, t dbSNP:749899115
545 545 c, t dbSNP:368302386
546 546 a, g dbSNP:41264503
547 547 a, c, t dbSNP:768586554
549 549 c, t dbSNP:760482982
550 550 a, g dbSNP:750393357
556 556 c, t dbSNP:772292386
558 558 c, t dbSNP:745987902
567 567 c, t dbSNP:765069844
568 568 c, t dbSNP:143476012
580 580 g, t dbSNP:375464241
582 582 a, g, t dbSNP:138365730
585 585 c, t dbSNP:113617017
586 586 c, t dbSNP:1180318
587 587 c, t dbSNP:753064125
593 593 a, g dbSNP:533557688
603 603 a, t dbSNP:564488541
614 614 c, t dbSNP:140829574
625 625 c, t dbSNP:267598593
631 631 a, g dbSNP:753971979
636 636 a, c, g dbSNP:146516387
639 639 a, g dbSNP:753832825
645 645 a, g, t dbSNP:374656603
646 646 c, g dbSNP:370285415
650 650 c, g, t dbSNP:772226518
655 655 c, g dbSNP:759795912
657 657 c, t dbSNP:774348910
663 663 c, g, t dbSNP:115716116
664 664 c, t dbSNP:778282702
666 666 c, t dbSNP:371317210
667 667 g, t dbSNP:115068989
671 671 c, t dbSNP:772073154
682 682 a, g dbSNP:199627999
683 683 c, g dbSNP:112803927
695 695 c, g dbSNP:778643736
698 698 a, c dbSNP:756861621
703 703 c, t dbSNP:753352796
704 704 a, g dbSNP:764180477
708 708 c, t dbSNP:756052085
709 709 a, g dbSNP:752497647
718 718 c, t dbSNP:767327706
719 719 a, c, g, t dbSNP:766546094
729 729 a, c dbSNP:763041211
739 739 c, t dbSNP:773253750
748 748 c, t dbSNP:374807919
749 749 a, g dbSNP:372916805
753 753 a, g dbSNP:78932473
769 769 c, t dbSNP:769070110
785 785 c, t dbSNP:747298126
787 787 c, t dbSNP:778733690
796 796 c, t dbSNP:756951380
797 797 a, g dbSNP:748851931
810 810 a, g dbSNP:375295630
820 820 c, t dbSNP:372340302
831 831 c, t dbSNP:559775469
832 832 a, g dbSNP:752690094
836 836 c, t dbSNP:201840029
845 845 a, g dbSNP:200662775
850 850 c, g dbSNP:1737738
851 851 c, g dbSNP:1737737
864 864 c, t dbSNP:751304032
866 866 c, t dbSNP:370502372
867 867 c, t dbSNP:766635894
868 868 g, t dbSNP:576981180
872 872 a, c dbSNP:773346563
876 876 c, t dbSNP:267598592
880 880 c, t dbSNP:765315524
888 888 c, t dbSNP:749644621
891 891 c, g dbSNP:200236163
905 905 g, t dbSNP:768998658
913 913 a, g, t dbSNP:775969852
917 917 c, g, t dbSNP:201157311
918 918 a, g dbSNP:777506480
925 925 g, t dbSNP:769348003
930 930 a, g dbSNP:201707555
934 934 -, g dbSNP:368717907
939 939 -, c dbSNP:771597427
944 944 c, g, t dbSNP:377079448
972 972 a, g dbSNP:554192451
974 974 a, g dbSNP:754847437
977 977 c, t dbSNP:751395824
979 979 g, t dbSNP:534299990
980 980 c, g, t dbSNP:199521829
988 988 a, g dbSNP:765338498
990 990 a, g dbSNP:139544750
1003 1003 g, t dbSNP:753842517
1006 1006 g, t dbSNP:558635363
1009 1009 g, t dbSNP:764705377
1020 1020 -, tgaaatcgg dbSNP:749770548
1020 1020 g, t dbSNP:371583375
1027 1027 a, g dbSNP:776059831
1045 1045 c, g dbSNP:772575144
1049 1049 c, t dbSNP:764222546
1051 1051 c, t dbSNP:183890301
1054 1054 c, t dbSNP:191371215
1057 1057 c, t dbSNP:759910471
1062 1062 c, t dbSNP:150591457
1104 1104 a, g dbSNP:550856748
1105 1105 c, t dbSNP:531270507
1124 1124 c, t dbSNP:527386529
1128 1128 a, c, g dbSNP:2695320
1133 1133 c, g dbSNP:750013021
1173 1173 a, c dbSNP:528479111
1175 1175 c, t dbSNP:765261851
1193 1193 c, t dbSNP:559450152
1212 1212 a, t dbSNP:115608339
1215 1215 c, t dbSNP:143702140
1224 1224 c, t dbSNP:188142662
1279 1279 c, t dbSNP:548817491
1286 1286 a, g dbSNP:183266275
1305 1305 c, g dbSNP:574422527
1316 1316 g, t dbSNP:554431129
1330 1330 c, t dbSNP:540895508
1362 1362 c, g dbSNP:41264501
1387 1387 c, g dbSNP:558220549
1397 1397 -, accagg dbSNP:2307917
1400 1400 -, aggacc dbSNP:201450931
1428 1428 c, t dbSNP:552280913
1451 1451 a, g dbSNP:538737122
1460 1460 g, t dbSNP:569642442
1466 1466 c, t dbSNP:753664881
1478 1478 a, g dbSNP:376779376
1508 1508 a, g dbSNP:763815500
1527 1527 g, t dbSNP:557578449
1554 1554 -, g dbSNP:137911802
1561 1561 c, g dbSNP:190993934
1603 1603 a, c dbSNP:563024194
1626 1626 c, t dbSNP:375847567
1683 1683 c, t dbSNP:755620716
1755 1755 c, t dbSNP:760908899
1769 1769 c, g dbSNP:775579059
1786 1786 -, tg dbSNP:771391854
1833 1833 a, g dbSNP:568805127
1849 1849 c, t dbSNP:767575178
1865 1865 a, c dbSNP:147241011
1878 1878 c, t dbSNP:759594991
1879 1879 a, g dbSNP:774475980
1884 1884 c, t dbSNP:528765186
1900 1900 a, c dbSNP:188708237
1903 1903 a, t dbSNP:552246769
1904 1904 c, t dbSNP:559685317
1910 1910 g, t dbSNP:771393922
1933 1933 a, g dbSNP:749839999
1951 1951 a, g dbSNP:532688278
1963 1963 a, g dbSNP:376278740
2005 2005 g, t dbSNP:549601918
2010 2010 c, t dbSNP:143934134
2026 2026 g, t dbSNP:560722152
2030 2030 a, g dbSNP:148112227
2098 2098 c, t dbSNP:11206478
2099 2099 c, g dbSNP:564937424
2189 2189 a, g dbSNP:544674309
2192 2192 a, g dbSNP:576115030
2201 2201 c, t dbSNP:560538573
2202 2202 c, t dbSNP:182773043
2203 2203 c, t dbSNP:536317655
2257 2257 a, g dbSNP:575104511
2284 2284 c, t dbSNP:767088418
2288 2288 c, t dbSNP:117679560
2318 2318 c, t dbSNP:540325312
2319 2319 g, t dbSNP:12049221
2367 2367 c, g dbSNP:566231366
2371 2371 a, c dbSNP:778617301
2379 2379 c, t dbSNP:143683714
2393 2393 c, t dbSNP:552571643
2397 2397 g, t dbSNP:538642690
2405 2405 c, g dbSNP:148982776
2412 2412 c, g dbSNP:41264499
2441 2441 a, g dbSNP:530089320
2464 2464 a, g dbSNP:138871678
2465 2465 a, g dbSNP:777557147
2472 2472 -, gttca dbSNP:750193277
2585 2585 a, g dbSNP:547181648
2631 2631 -, g dbSNP:766204608
2649 2649 a, g dbSNP:527632820
2667 2667 c, t dbSNP:755874286
2675 2675 c, t dbSNP:565009299
2706 2706 g, t dbSNP:545021876
2707 2707 c, t dbSNP:575964222
2717 2717 g, t dbSNP:562437127
2738 2738 c, g dbSNP:372407957
2776 2776 c, t dbSNP:752592131
2795 2795 c, t dbSNP:41264497
2808 2808 a, g dbSNP:535251181
2809 2809 a, g dbSNP:575868941
2817 2817 a, g dbSNP:555240800
2841 2841 a, t dbSNP:534886445
2857 2857 a, g dbSNP:190986521
2873 2873 c, g dbSNP:559005718
2886 2886 a, c dbSNP:543421470
2914 2914 a, g dbSNP:539294029
2966 2966 c, t dbSNP:772082951
2982 2982 a, c dbSNP:539771599
3043 3043 a, g dbSNP:186178580
3056 3056 c, g dbSNP:569718016
3110 3110 c, t dbSNP:745811962
3115 3115 a, g dbSNP:549724585
3134 3134 c, t dbSNP:536388733
3142 3142 c, g dbSNP:778818220
3144 3144 a, g dbSNP:375034027
3165 3165 c, t dbSNP:11554176
3174 3174 g, t dbSNP:41264495
3202 3202 a, c dbSNP:763387335
3211 3211 g, t dbSNP:547216509
3218 3218 c, t dbSNP:41264493
3225 3225 c, t dbSNP:41264491
3242 3242 c, g dbSNP:375071116
3272 3272 c, t dbSNP:6587
3291 3291 c, t dbSNP:548338263
3300 3300 c, g dbSNP:531584592
3355 3355 c, t dbSNP:78706896
3356 3356 a, g dbSNP:542633090
3446 3446 g, t dbSNP:180995630
3470 3470 c, t dbSNP:529043487
3485 3485 a, c dbSNP:560276047
3509 3509 a, g dbSNP:540291443
3516 3516 c, t dbSNP:771830719
3547 3547 c, g dbSNP:140314362
3549 3549 c, g dbSNP:752337633
3575 3575 c, t dbSNP:559065410
3581 3581 c, g dbSNP:545387557
3593 3593 a, g dbSNP:531931512
3617 3617 c, g dbSNP:576319266
3619 3619 a, g dbSNP:745539827
3622 3622 a, g dbSNP:12030495
3628 3628 a, c dbSNP:770567619
3654 3654 c, t dbSNP:2695321
3673 3673 c, t dbSNP:200913639
3675 3675 a, c dbSNP:552545622
3727 3727 c, t dbSNP:151170453
3741 3741 a, t dbSNP:534271665
3748 3748 a, g dbSNP:756140334
3758 3758 c, g dbSNP:142093126
3792 3792 a, c dbSNP:116401702
3809 3809 a, c dbSNP:114297514
3847 3847 a, c dbSNP:12022423
3852 3852 c, t dbSNP:765821510
3856 3856 a, g dbSNP:755140248
3861 3861 a, g dbSNP:372439881
3892 3892 a, g dbSNP:549035554
3898 3898 a, c, t dbSNP:528912772
3900 3900 a, g dbSNP:560162992
3932 3932 c, g dbSNP:539955756
3952 3952 a, t dbSNP:533007649
3964 3964 c, t dbSNP:762933616
4005 4005 a, t dbSNP:565382100
4062 4062 a, g dbSNP:189693750
4068 4068 a, g dbSNP:765632241

Target ORF information:

RefSeq Version NM_014571
Organism Homo sapiens (human)
Definition Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014571

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCGAC CCAAGGAGCC GAGCGGCTCC GACGGGGAGT CCGACGGACC CATCGACGTG 
GGCCAAGAGG GCCAGCTGAG CCAGATGGCC AGGCCGCTGT CCACCCCCAG CTCTTCGCAG
ATGCAAGCCA GGAAGAAACG CAGAGGGATC ATAGAGAAAC GGCGTCGAGA CCGCATCAAC
AGTAGCCTTT CTGAATTGCG ACGCTTGGTC CCCACTGCCT TTGAGAAACA GGGCTCTTCC
AAGCTGGAGA AAGCCGAGGT CTTGCAGATG ACGGTGGATC ACTTGAAAAT GCTCCATGCC
ACTGGTGGGA CAGGATTCTT TGATGCCCGA GCCCTGGCAG TTGACTTCCG GAGCATTGGT
TTTCGGGAGT GCCTCACTGA GGTCATCAGG TACCTGGGGG TCCTTGAAGG GCCCAGCAGC
CGTGCAGACC CCGTCCGGAT TCGCCTTCTC TCCCACCTCA ACAGCTACGC AGCCGAGATG
GAGCCTTCGC CCACGCCCAC TGGCCCTTTG GCCTTCCCTG CCTGGCCCTG GTCTTTCTTC
CATAGCTGTC CAGGGCTGCC AGCCCTGAGC AACCAGCTCG CCATCCTGGG AAGAGTGCCC
AGCCCTGTCC TCCCCGGTGT CTCCTCTCCT GCTTACCCCA TCCCAGCCCT CCGAACCGCT
CCCCTTCGCA GAGCCACAGG CATCATCCTG CCAGCCCGGA GGAATGTGCT GCCCAGTCGA
GGGGCATCTT CCACCCGGAG GGCCCGCCCC CTAGAGAGGC CAGCGACCCC TGTGCCTGTC
GCCCCCAGCA GCAGGGCTGC CAGGAGCAGC CACATCGCTC CCCTCCTGCA GTCTTCCTCC
CCAACACCCC CTGGTCCTAC AGGGTCGGCT GCTTACGTGG CTGTTCCCAC CCCCAACTCA
TCCTCCCCAG GGCCAGCTGG GAGGCCAGCG GGAGCCATGC TCTACCACTC CTGGGTCTCT
GAAATCACTG AAATCGGGGC TTTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.