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GH1 growth hormone 1 [Homo sapiens (human)]

Gene Symbol GH1
Entrez Gene ID 2688
Full Name growth hormone 1
Synonyms GH, GH-N, GHN, IGHD1B, hGH-N
General protein information
Preferred Names
somatotropin
Names
somatotropin
pituitary growth hormone
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q24.2

Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

139250

Disorder Html: Growth hormone deficiency, isolated, type IA, 262400 (3); Growth
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu57964 XM_011524612 PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu27940 NM_000515 Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu25686 NM_022559 Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu25687 NM_022560 Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu57964D
Sequence Information ORF Nucleotide Sequence (Length: 654bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product somatotropin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010783.16) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGGCTCCAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_011522914.1
CDS16..669
Misc Feature(1)118..660(+)
Misc Feature(2)118..660(+)
Translation
Position Chain Variation Link
1 1 g, t dbSNP:752877135
2 2 c, t dbSNP:767864638
6 6 a, c dbSNP:760090194
7 7 c, g dbSNP:774519450
11 11 c, t dbSNP:771309275
12 12 c, g, t dbSNP:6173
13 13 a, g dbSNP:772819563
15 15 a, g dbSNP:370696298
20 20 c, t dbSNP:111801128
23 23 c, t dbSNP:776343106
27 27 c, t dbSNP:146624652
30 30 c, t dbSNP:111957225
31 31 a, c, g, t dbSNP:140576665
32 32 a, g, t dbSNP:376469157
33 33 a, g dbSNP:749131325
35 35 a, c, t dbSNP:768782282
36 36 a, c, g, t dbSNP:61762496
39 39 c, t dbSNP:750918971
56 56 c, g dbSNP:372110326
63 63 c, g dbSNP:151294724
65 65 -, g dbSNP:752365662
66 66 c, t dbSNP:377278914
70 70 c, t dbSNP:376449159
74 74 a, g dbSNP:137853219
81 81 a, g dbSNP:754207595
93 93 a, c, t dbSNP:367600150
98 98 a, c dbSNP:760279051
99 99 a, g dbSNP:374895443
103 103 a, g dbSNP:767119011
104 104 c, t dbSNP:759181460
105 105 c, t dbSNP:774395504
106 106 c, g dbSNP:771037676
108 108 c, t dbSNP:762759144
109 109 g, t dbSNP:778910515
110 110 c, t dbSNP:772909638
116 116 a, g dbSNP:544000207
127 127 a, c, t dbSNP:780382626
129 129 c, g, t dbSNP:745988896
130 130 a, g dbSNP:779374598
131 131 c, t dbSNP:151263636
133 133 a, c dbSNP:754194422
136 136 c, t dbSNP:778008637
139 139 c, t dbSNP:71640273
140 140 a, g, t dbSNP:371953554
141 141 a, c, t dbSNP:751135936
142 142 a, g dbSNP:140787052
146 146 a, g dbSNP:754126557
148 148 a, c, t dbSNP:764929278
149 149 a, g dbSNP:71640274
150 150 c, t dbSNP:775659576
151 151 c, g dbSNP:772330168
152 152 c, t dbSNP:745903951
154 154 c, t dbSNP:145327622
160 160 c, g dbSNP:769678192
163 163 a, g dbSNP:544949394
165 165 ata, ctt dbSNP:386798325
165 165 a, c, g dbSNP:61735359
166 166 a, t dbSNP:778408321
167 167 a, t dbSNP:61735357
171 171 c, t dbSNP:577521176
175 175 c, t dbSNP:780939487
177 177 c, t dbSNP:754708691
178 178 c, t dbSNP:534146444
179 179 a, g dbSNP:751046106
186 186 c, t dbSNP:765998918
198 198 c, t dbSNP:771781033
203 203 c, t dbSNP:745333035
204 204 a, g dbSNP:778492342
208 208 a, g dbSNP:757132569
210 210 a, c, g dbSNP:530697485
221 221 c, g dbSNP:755877694
227 227 c, t dbSNP:752508922
228 228 a, g dbSNP:766468566
232 232 a, g dbSNP:71640276
234 234 a, c dbSNP:750410681
235 235 a, c dbSNP:765345439
237 237 a, c, g dbSNP:777246983
249 249 -, ct dbSNP:767112294
251 251 c, g, t dbSNP:137853222
252 252 c, t dbSNP:564855058
257 257 c, g dbSNP:761074249
261 261 c, g dbSNP:61762497
270 270 a, g dbSNP:771560181
276 276 c, t dbSNP:745549585
278 278 c, g dbSNP:778491746
283 283 a, c dbSNP:200498241
294 294 a, g dbSNP:572761421
306 306 c, t dbSNP:201518977
309 309 c, t dbSNP:768500322
310 310 a, c dbSNP:746780250
318 318 a, g dbSNP:557973956
322 322 c, t dbSNP:137853220
323 323 a, g dbSNP:757500095
329 329 c, g dbSNP:6174
331 331 c, t dbSNP:749511152
342 342 c, t dbSNP:139163836
343 343 c, g dbSNP:150761983
346 346 c, t dbSNP:752738695
347 347 c, t dbSNP:781692092
348 348 a, g dbSNP:71640278
354 354 g, t dbSNP:751860506
356 356 a, g dbSNP:766715590
360 360 c, g, t dbSNP:144610881
361 361 a, g, t dbSNP:377027593
364 364 a, c dbSNP:776036784
365 365 a, g dbSNP:142396035
367 367 c, t dbSNP:372776291
370 370 c, g dbSNP:775630395
372 372 c, g dbSNP:548995389
374 374 a, g dbSNP:368658744
378 378 a, c, g, t dbSNP:137882374
384 384 c, t dbSNP:748188371
385 385 a, g dbSNP:373958758
394 394 c, t dbSNP:755141415
396 396 a, g dbSNP:752055083
398 398 c, t dbSNP:780577159
402 402 a, c, t dbSNP:370785603
403 403 a, c, g dbSNP:201524858
405 405 c, t dbSNP:143833877
406 406 a, g dbSNP:753333968
411 411 g, t dbSNP:763501141
413 413 a, t dbSNP:199885167
418 418 a, g dbSNP:775540749
420 420 c, t dbSNP:41295041
421 421 a, g dbSNP:5388
423 423 c, t dbSNP:774017931
424 424 c, t dbSNP:769998616
428 428 a, g dbSNP:137853221
438 438 g, t dbSNP:748302020
439 439 a, g dbSNP:781542704
441 441 c, g dbSNP:768585995
450 450 a, t dbSNP:747139860
451 451 a, g, t dbSNP:758934916
461 461 c, t dbSNP:764140330
462 462 a, g dbSNP:41295043
465 465 c, g dbSNP:113379310
469 469 g, t dbSNP:753431488
471 471 g, t dbSNP:763850922
473 473 c, g dbSNP:755101832
474 474 a, g dbSNP:200925254
481 481 g, t dbSNP:770336766
482 482 a, t dbSNP:747795015
483 483 c, t dbSNP:201849388
485 485 a, g dbSNP:201165777
491 491 a, c, g dbSNP:41295253
493 493 c, t dbSNP:377600944
494 494 a, g, t dbSNP:41295255
495 495 c, g, t dbSNP:541629121
496 496 a, c, g dbSNP:572278056
502 502 a, c dbSNP:767778677
504 504 a, g dbSNP:759488326
508 508 c, t dbSNP:138880244
517 517 a, t dbSNP:771280061
521 521 a, g dbSNP:763500259
522 522 c, t dbSNP:773919353
528 528 a, g dbSNP:770248985
531 531 c, t dbSNP:4080075
532 532 a, g dbSNP:780941513
536 536 a, c dbSNP:768385118
540 540 a, c dbSNP:4080076
543 543 a, g dbSNP:397843499
545 545 a, g dbSNP:746437614
550 550 a, c, g dbSNP:151243538
554 554 a, c dbSNP:750357948
555 555 c, t dbSNP:753806390
556 556 a, g dbSNP:371051668
561 561 a, g dbSNP:4080078
562 562 c, t dbSNP:184640372
573 573 c, t dbSNP:753659458
574 574 a, g dbSNP:200409102
578 578 c, t dbSNP:759813905
582 582 c, t dbSNP:751783545
583 583 c, t dbSNP:766455056
588 588 c, t dbSNP:763012167
591 591 c, t dbSNP:571549544
600 600 c, g dbSNP:770439032
601 601 a, g dbSNP:762202654
612 612 c, g, t dbSNP:142704768
613 613 a, g dbSNP:373184101
627 627 c, t dbSNP:369176887
628 628 a, g dbSNP:771605458
629 629 g, t dbSNP:745438654
630 630 c, g, t dbSNP:148474991
633 633 g, t dbSNP:749039024
637 637 c, t dbSNP:777606230
640 640 c, t dbSNP:755905735
641 641 a, g dbSNP:137853223
642 642 c, g dbSNP:534831938
644 644 c, t dbSNP:766570969
651 651 a, g dbSNP:144550695
652 652 c, g dbSNP:750536547
657 657 c, t dbSNP:565832360
659 659 a, g dbSNP:375006135
661 661 a, g dbSNP:762433340
663 663 c, t dbSNP:777326685
670 670 c, g dbSNP:764487763
675 675 c, t dbSNP:761010486
676 676 a, g dbSNP:775193583
684 684 c, t dbSNP:771633757
685 685 a, c dbSNP:745307487
687 687 -, c dbSNP:772991248
693 693 c, t dbSNP:773878012
694 694 a, c, t dbSNP:749195779
695 695 a, c dbSNP:777642354
697 697 c, t dbSNP:755927336
702 702 a, g dbSNP:747910969
706 706 a, c dbSNP:201439757
709 709 c, t dbSNP:371688045
711 711 c, t dbSNP:750483022
716 716 a, c, t dbSNP:368234783
718 718 c, g dbSNP:754364357
721 721 -, g dbSNP:769939750
724 724 a, g, t dbSNP:761040508
725 725 g, t dbSNP:753006438
729 729 c, t dbSNP:767154356
746 746 a, g dbSNP:759204564
753 753 c, t dbSNP:755646836
765 765 a, g dbSNP:774036261
767 767 a, g dbSNP:770427079
769 769 g, t dbSNP:762510331
773 773 c, t dbSNP:773146940
774 774 c, t dbSNP:752350267

Target ORF information:

RefSeq Version XM_011524612
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_011524612

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCTCCAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu27940D
Sequence Information ORF Nucleotide Sequence (Length: 654bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product somatotropin isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC090045.1 and AV753220.1. This sequence is a reference standard in the RefSeqGene project. On May 21, 2014 this sequence version replaced gi:20809248. Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY613431.1, AY613432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000506.2
CDS77..730
Misc Feature(1)179..721(+)
Misc Feature(2)179..721(+)
Misc Feature(3)311..649(+)
Misc Feature(4)470..472(+)
Misc Feature(5)470..472(+)
Misc Feature(6)563..565(+)
Misc Feature(7)602..604(+)
Misc Feature(8)602..604(+)
Misc Feature(9)608..610(+)
Misc Feature(10)698..721(+)
Exon (1)1..86
Gene:GH1
Gene Synonym:
Exon (2)87..247
Gene:GH1
Gene Synonym:
Exon (3)248..367
Gene:GH1
Gene Synonym:
Exon (4)368..532
Gene:GH1
Gene Synonym:
Exon (5)533..846
Gene:GH1
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:749272057
3 3 g, t dbSNP:774824249
4 4 a, g dbSNP:769351800
6 6 a, g dbSNP:745465815
9 9 a, g dbSNP:6171
14 14 a, c, t dbSNP:695
17 17 c, g dbSNP:6175
24 24 a, g dbSNP:370080186
30 30 a, g dbSNP:9282699
31 31 a, c dbSNP:777455884
34 34 a, c, t dbSNP:747695752
37 37 -, c dbSNP:755560241
37 37 c, t dbSNP:368843010
39 39 a, c dbSNP:6172
41 41 a, c dbSNP:751274337
47 47 a, g dbSNP:200562012
49 49 g, t dbSNP:757365673
50 50 g, t dbSNP:754099689
52 52 c, t dbSNP:757493647
54 54 g, t dbSNP:764482889
56 56 a, t dbSNP:760810115
62 62 g, t dbSNP:752877135
63 63 c, t dbSNP:767864638
67 67 a, c dbSNP:760090194
68 68 c, g dbSNP:774519450
72 72 c, t dbSNP:771309275
73 73 c, g, t dbSNP:6173
74 74 a, g dbSNP:772819563
76 76 a, g dbSNP:370696298
81 81 c, t dbSNP:111801128
83 83 a, c, g dbSNP:2001345
88 88 c, t dbSNP:146624652
91 91 c, t dbSNP:111957225
92 92 a, c, g, t dbSNP:140576665
93 93 a, g, t dbSNP:376469157
94 94 a, g dbSNP:749131325
96 96 a, c, t dbSNP:768782282
97 97 a, c, g, t dbSNP:61762496
100 100 c, t dbSNP:750918971
117 117 c, g dbSNP:372110326
124 124 c, g dbSNP:151294724
126 126 -, g dbSNP:752365662
127 127 c, t dbSNP:377278914
131 131 c, t dbSNP:376449159
135 135 a, g dbSNP:137853219
142 142 a, g dbSNP:754207595
154 154 a, c, t dbSNP:367600150
159 159 a, c dbSNP:760279051
160 160 a, g dbSNP:374895443
164 164 a, g dbSNP:767119011
165 165 c, t dbSNP:759181460
166 166 c, t dbSNP:774395504
167 167 c, g dbSNP:771037676
169 169 c, t dbSNP:762759144
170 170 g, t dbSNP:778910515
171 171 c, t dbSNP:772909638
177 177 a, g dbSNP:544000207
188 188 a, c, t dbSNP:780382626
190 190 c, g, t dbSNP:745988896
191 191 a, g dbSNP:779374598
192 192 c, t dbSNP:151263636
194 194 a, c dbSNP:754194422
197 197 c, t dbSNP:778008637
200 200 c, t dbSNP:71640273
201 201 a, g, t dbSNP:371953554
202 202 a, c, t dbSNP:751135936
203 203 a, g dbSNP:140787052
207 207 a, g dbSNP:754126557
209 209 a, c, t dbSNP:764929278
210 210 a, g dbSNP:71640274
211 211 c, t dbSNP:775659576
212 212 c, g dbSNP:772330168
213 213 c, t dbSNP:745903951
215 215 c, t dbSNP:145327622
221 221 c, g dbSNP:769678192
224 224 a, g dbSNP:544949394
226 226 ata, ctt dbSNP:386798325
226 226 a, c, g dbSNP:61735359
227 227 a, t dbSNP:778408321
228 228 a, t dbSNP:61735357
232 232 c, t dbSNP:577521176
236 236 c, t dbSNP:780939487
238 238 c, t dbSNP:754708691
239 239 c, t dbSNP:534146444
240 240 a, g dbSNP:751046106
247 247 c, t dbSNP:765998918
259 259 c, t dbSNP:771781033
264 264 c, t dbSNP:745333035
265 265 a, g dbSNP:778492342
269 269 a, g dbSNP:757132569
271 271 a, c, g dbSNP:530697485
282 282 c, g dbSNP:755877694
288 288 c, t dbSNP:752508922
289 289 a, g dbSNP:766468566
293 293 a, g dbSNP:71640276
295 295 a, c dbSNP:750410681
296 296 a, c dbSNP:765345439
298 298 a, c, g dbSNP:777246983
310 310 -, ct dbSNP:767112294
312 312 c, g, t dbSNP:137853222
313 313 c, t dbSNP:564855058
318 318 c, g dbSNP:761074249
322 322 c, g dbSNP:61762497
331 331 a, g dbSNP:771560181
337 337 c, t dbSNP:745549585
339 339 c, g dbSNP:778491746
344 344 a, c dbSNP:200498241
355 355 a, g dbSNP:572761421
367 367 c, t dbSNP:201518977
370 370 c, t dbSNP:768500322
371 371 a, c dbSNP:746780250
379 379 a, g dbSNP:557973956
383 383 c, t dbSNP:137853220
384 384 a, g dbSNP:757500095
390 390 c, g dbSNP:6174
392 392 c, t dbSNP:749511152
403 403 c, t dbSNP:139163836
404 404 c, g dbSNP:150761983
407 407 c, t dbSNP:752738695
408 408 c, t dbSNP:781692092
409 409 a, g dbSNP:71640278
415 415 g, t dbSNP:751860506
417 417 a, g dbSNP:766715590
421 421 c, g, t dbSNP:144610881
422 422 a, g, t dbSNP:377027593
425 425 a, c dbSNP:776036784
426 426 a, g dbSNP:142396035
428 428 c, t dbSNP:372776291
431 431 c, g dbSNP:775630395
433 433 c, g dbSNP:548995389
435 435 a, g dbSNP:368658744
439 439 a, c, g, t dbSNP:137882374
445 445 c, t dbSNP:748188371
446 446 a, g dbSNP:373958758
455 455 c, t dbSNP:755141415
457 457 a, g dbSNP:752055083
459 459 c, t dbSNP:780577159
463 463 a, c, t dbSNP:370785603
464 464 a, c, g dbSNP:201524858
466 466 c, t dbSNP:143833877
467 467 a, g dbSNP:753333968
472 472 g, t dbSNP:763501141
474 474 a, t dbSNP:199885167
479 479 a, g dbSNP:775540749
481 481 c, t dbSNP:41295041
482 482 a, g dbSNP:5388
484 484 c, t dbSNP:774017931
485 485 c, t dbSNP:769998616
489 489 a, g dbSNP:137853221
499 499 g, t dbSNP:748302020
500 500 a, g dbSNP:781542704
502 502 c, g dbSNP:768585995
511 511 a, t dbSNP:747139860
512 512 a, g, t dbSNP:758934916
522 522 c, t dbSNP:764140330
523 523 a, g dbSNP:41295043
526 526 c, g dbSNP:113379310
530 530 g, t dbSNP:753431488
532 532 g, t dbSNP:763850922
534 534 c, g dbSNP:755101832
535 535 a, g dbSNP:200925254
542 542 g, t dbSNP:770336766
543 543 a, t dbSNP:747795015
544 544 c, t dbSNP:201849388
546 546 a, g dbSNP:201165777
552 552 a, c, g dbSNP:41295253
554 554 c, t dbSNP:377600944
555 555 a, g, t dbSNP:41295255
556 556 c, g, t dbSNP:541629121
557 557 a, c, g dbSNP:572278056
563 563 a, c dbSNP:767778677
565 565 a, g dbSNP:759488326
569 569 c, t dbSNP:138880244
578 578 a, t dbSNP:771280061
582 582 a, g dbSNP:763500259
583 583 c, t dbSNP:773919353
589 589 a, g dbSNP:770248985
592 592 c, t dbSNP:4080075
593 593 a, g dbSNP:780941513
597 597 a, c dbSNP:768385118
601 601 a, c dbSNP:4080076
604 604 a, g dbSNP:397843499
606 606 a, g dbSNP:746437614
611 611 a, c, g dbSNP:151243538
615 615 a, c dbSNP:750357948
616 616 c, t dbSNP:753806390
617 617 a, g dbSNP:371051668
622 622 a, g dbSNP:4080078
623 623 c, t dbSNP:184640372
634 634 c, t dbSNP:753659458
635 635 a, g dbSNP:200409102
639 639 c, t dbSNP:759813905
643 643 c, t dbSNP:751783545
644 644 c, t dbSNP:766455056
649 649 c, t dbSNP:763012167
652 652 c, t dbSNP:571549544
661 661 c, g dbSNP:770439032
662 662 a, g dbSNP:762202654
673 673 c, g, t dbSNP:142704768
674 674 a, g dbSNP:373184101
688 688 c, t dbSNP:369176887
689 689 a, g dbSNP:771605458
690 690 g, t dbSNP:745438654
691 691 c, g, t dbSNP:148474991
694 694 g, t dbSNP:749039024
698 698 c, t dbSNP:777606230
701 701 c, t dbSNP:755905735
702 702 a, g dbSNP:137853223
703 703 c, g dbSNP:534831938
705 705 c, t dbSNP:766570969
712 712 a, g dbSNP:144550695
713 713 c, g dbSNP:750536547
718 718 c, t dbSNP:565832360
720 720 a, g dbSNP:375006135
722 722 a, g dbSNP:762433340
724 724 c, t dbSNP:777326685
731 731 c, g dbSNP:764487763
736 736 c, t dbSNP:761010486
737 737 a, g dbSNP:775193583
745 745 c, t dbSNP:771633757
746 746 a, c dbSNP:745307487
748 748 -, c dbSNP:772991248
754 754 c, t dbSNP:773878012
755 755 a, c, t dbSNP:749195779
756 756 a, c dbSNP:777642354
758 758 c, t dbSNP:755927336
763 763 a, g dbSNP:747910969
767 767 a, c dbSNP:201439757
770 770 c, t dbSNP:371688045
772 772 c, t dbSNP:750483022
777 777 a, c, t dbSNP:368234783
779 779 c, g dbSNP:754364357
782 782 -, g dbSNP:769939750
785 785 a, g, t dbSNP:761040508
786 786 g, t dbSNP:753006438
790 790 c, t dbSNP:767154356
807 807 a, g dbSNP:759204564
814 814 c, t dbSNP:755646836
826 826 a, g dbSNP:774036261
828 828 a, g dbSNP:770427079
830 830 g, t dbSNP:762510331
834 834 c, t dbSNP:773146940
835 835 c, t dbSNP:752350267
840 840 c, t dbSNP:747936835
841 841 a, g dbSNP:780872438
844 844 c, t dbSNP:768621233

Target ORF information:

RefSeq Version NM_000515
Organism Homo sapiens (human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_000515

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25686D
Sequence Information ORF Nucleotide Sequence (Length: 609bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product somatotropin isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC062475.1 and AV753220.1. On May 21, 2014 this sequence version replaced gi:20809249. Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD251386.1, CD105630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2153307 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT
GGCTTCTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_072053.1
CDS77..685
Misc Feature(1)179..676(+)
Misc Feature(2)179..676(+)
Misc Feature(3)425..427(+)
Misc Feature(4)557..559(+)
Exon (1)1..86
Gene:GH1
Gene Synonym:
Exon (2)87..247
Gene:GH1
Gene Synonym:
Exon (3)248..322
Gene:GH1
Gene Synonym:
Exon (4)323..487
Gene:GH1
Gene Synonym:
Exon (5)488..801
Gene:GH1
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:749272057
3 3 g, t dbSNP:774824249
4 4 a, g dbSNP:769351800
6 6 a, g dbSNP:745465815
9 9 a, g dbSNP:6171
14 14 a, c, t dbSNP:695
17 17 c, g dbSNP:6175
24 24 a, g dbSNP:370080186
30 30 a, g dbSNP:9282699
31 31 a, c dbSNP:777455884
34 34 a, c, t dbSNP:747695752
37 37 -, c dbSNP:755560241
37 37 c, t dbSNP:368843010
39 39 a, c dbSNP:6172
41 41 a, c dbSNP:751274337
47 47 a, g dbSNP:200562012
49 49 g, t dbSNP:757365673
50 50 g, t dbSNP:754099689
52 52 c, t dbSNP:757493647
54 54 g, t dbSNP:764482889
56 56 a, t dbSNP:760810115
62 62 g, t dbSNP:752877135
63 63 c, t dbSNP:767864638
67 67 a, c dbSNP:760090194
68 68 c, g dbSNP:774519450
72 72 c, t dbSNP:771309275
73 73 c, g, t dbSNP:6173
74 74 a, g dbSNP:772819563
76 76 a, g dbSNP:370696298
81 81 c, t dbSNP:111801128
83 83 a, c, g dbSNP:2001345
88 88 c, t dbSNP:146624652
91 91 c, t dbSNP:111957225
92 92 a, c, g, t dbSNP:140576665
93 93 a, g, t dbSNP:376469157
94 94 a, g dbSNP:749131325
96 96 a, c, t dbSNP:768782282
97 97 a, c, g, t dbSNP:61762496
100 100 c, t dbSNP:750918971
117 117 c, g dbSNP:372110326
124 124 c, g dbSNP:151294724
126 126 -, g dbSNP:752365662
127 127 c, t dbSNP:377278914
131 131 c, t dbSNP:376449159
135 135 a, g dbSNP:137853219
142 142 a, g dbSNP:754207595
154 154 a, c, t dbSNP:367600150
159 159 a, c dbSNP:760279051
160 160 a, g dbSNP:374895443
164 164 a, g dbSNP:767119011
165 165 c, t dbSNP:759181460
166 166 c, t dbSNP:774395504
167 167 c, g dbSNP:771037676
169 169 c, t dbSNP:762759144
170 170 g, t dbSNP:778910515
171 171 c, t dbSNP:772909638
177 177 a, g dbSNP:544000207
188 188 a, c, t dbSNP:780382626
190 190 c, g, t dbSNP:745988896
191 191 a, g dbSNP:779374598
192 192 c, t dbSNP:151263636
194 194 a, c dbSNP:754194422
197 197 c, t dbSNP:778008637
200 200 c, t dbSNP:71640273
201 201 a, g, t dbSNP:371953554
202 202 a, c, t dbSNP:751135936
203 203 a, g dbSNP:140787052
207 207 a, g dbSNP:754126557
209 209 a, c, t dbSNP:764929278
210 210 a, g dbSNP:71640274
211 211 c, t dbSNP:775659576
212 212 c, g dbSNP:772330168
213 213 c, t dbSNP:745903951
215 215 c, t dbSNP:145327622
221 221 c, g dbSNP:769678192
224 224 a, g dbSNP:544949394
226 226 ata, ctt dbSNP:386798325
226 226 a, c, g dbSNP:61735359
227 227 a, t dbSNP:778408321
228 228 a, t dbSNP:61735357
232 232 c, t dbSNP:577521176
236 236 c, t dbSNP:780939487
238 238 c, t dbSNP:754708691
239 239 c, t dbSNP:534146444
240 240 a, g dbSNP:751046106
247 247 c, t dbSNP:765998918
248 248 a, g dbSNP:71640276
250 250 a, c dbSNP:750410681
251 251 a, c dbSNP:765345439
253 253 a, c, g dbSNP:777246983
265 265 -, ct dbSNP:767112294
267 267 c, g, t dbSNP:137853222
268 268 c, t dbSNP:564855058
273 273 c, g dbSNP:761074249
277 277 c, g dbSNP:61762497
286 286 a, g dbSNP:771560181
292 292 c, t dbSNP:745549585
294 294 c, g dbSNP:778491746
299 299 a, c dbSNP:200498241
310 310 a, g dbSNP:572761421
322 322 c, t dbSNP:201518977
325 325 c, t dbSNP:768500322
326 326 a, c dbSNP:746780250
334 334 a, g dbSNP:557973956
338 338 c, t dbSNP:137853220
339 339 a, g dbSNP:757500095
345 345 c, g dbSNP:6174
347 347 c, t dbSNP:749511152
358 358 c, t dbSNP:139163836
359 359 c, g dbSNP:150761983
362 362 c, t dbSNP:752738695
363 363 c, t dbSNP:781692092
364 364 a, g dbSNP:71640278
370 370 g, t dbSNP:751860506
372 372 a, g dbSNP:766715590
376 376 c, g, t dbSNP:144610881
377 377 a, g, t dbSNP:377027593
380 380 a, c dbSNP:776036784
381 381 a, g dbSNP:142396035
383 383 c, t dbSNP:372776291
386 386 c, g dbSNP:775630395
388 388 c, g dbSNP:548995389
390 390 a, g dbSNP:368658744
394 394 a, c, g, t dbSNP:137882374
400 400 c, t dbSNP:748188371
401 401 a, g dbSNP:373958758
410 410 c, t dbSNP:755141415
412 412 a, g dbSNP:752055083
414 414 c, t dbSNP:780577159
418 418 a, c, t dbSNP:370785603
419 419 a, c, g dbSNP:201524858
421 421 c, t dbSNP:143833877
422 422 a, g dbSNP:753333968
427 427 g, t dbSNP:763501141
429 429 a, t dbSNP:199885167
434 434 a, g dbSNP:775540749
436 436 c, t dbSNP:41295041
437 437 a, g dbSNP:5388
439 439 c, t dbSNP:774017931
440 440 c, t dbSNP:769998616
444 444 a, g dbSNP:137853221
454 454 g, t dbSNP:748302020
455 455 a, g dbSNP:781542704
457 457 c, g dbSNP:768585995
466 466 a, t dbSNP:747139860
467 467 a, g, t dbSNP:758934916
477 477 c, t dbSNP:764140330
478 478 a, g dbSNP:41295043
481 481 c, g dbSNP:113379310
485 485 g, t dbSNP:753431488
487 487 g, t dbSNP:763850922
489 489 c, g dbSNP:755101832
490 490 a, g dbSNP:200925254
497 497 g, t dbSNP:770336766
498 498 a, t dbSNP:747795015
499 499 c, t dbSNP:201849388
501 501 a, g dbSNP:201165777
507 507 a, c, g dbSNP:41295253
509 509 c, t dbSNP:377600944
510 510 a, g, t dbSNP:41295255
511 511 c, g, t dbSNP:541629121
512 512 a, c, g dbSNP:572278056
518 518 a, c dbSNP:767778677
520 520 a, g dbSNP:759488326
524 524 c, t dbSNP:138880244
533 533 a, t dbSNP:771280061
537 537 a, g dbSNP:763500259
538 538 c, t dbSNP:773919353
544 544 a, g dbSNP:770248985
547 547 c, t dbSNP:4080075
548 548 a, g dbSNP:780941513
552 552 a, c dbSNP:768385118
556 556 a, c dbSNP:4080076
559 559 a, g dbSNP:397843499
561 561 a, g dbSNP:746437614
566 566 a, c, g dbSNP:151243538
570 570 a, c dbSNP:750357948
571 571 c, t dbSNP:753806390
572 572 a, g dbSNP:371051668
577 577 a, g dbSNP:4080078
578 578 c, t dbSNP:184640372
589 589 c, t dbSNP:753659458
590 590 a, g dbSNP:200409102
594 594 c, t dbSNP:759813905
598 598 c, t dbSNP:751783545
599 599 c, t dbSNP:766455056
604 604 c, t dbSNP:763012167
607 607 c, t dbSNP:571549544
616 616 c, g dbSNP:770439032
617 617 a, g dbSNP:762202654
628 628 c, g, t dbSNP:142704768
629 629 a, g dbSNP:373184101
643 643 c, t dbSNP:369176887
644 644 a, g dbSNP:771605458
645 645 g, t dbSNP:745438654
646 646 c, g, t dbSNP:148474991
649 649 g, t dbSNP:749039024
653 653 c, t dbSNP:777606230
656 656 c, t dbSNP:755905735
657 657 a, g dbSNP:137853223
658 658 c, g dbSNP:534831938
660 660 c, t dbSNP:766570969
667 667 a, g dbSNP:144550695
668 668 c, g dbSNP:750536547
673 673 c, t dbSNP:565832360
675 675 a, g dbSNP:375006135
677 677 a, g dbSNP:762433340
679 679 c, t dbSNP:777326685
686 686 c, g dbSNP:764487763
691 691 c, t dbSNP:761010486
692 692 a, g dbSNP:775193583
700 700 c, t dbSNP:771633757
701 701 a, c dbSNP:745307487
703 703 -, c dbSNP:772991248
709 709 c, t dbSNP:773878012
710 710 a, c, t dbSNP:749195779
711 711 a, c dbSNP:777642354
713 713 c, t dbSNP:755927336
718 718 a, g dbSNP:747910969
722 722 a, c dbSNP:201439757
725 725 c, t dbSNP:371688045
727 727 c, t dbSNP:750483022
732 732 a, c, t dbSNP:368234783
734 734 c, g dbSNP:754364357
737 737 -, g dbSNP:769939750
740 740 a, g, t dbSNP:761040508
741 741 g, t dbSNP:753006438
745 745 c, t dbSNP:767154356
762 762 a, g dbSNP:759204564
769 769 c, t dbSNP:755646836
781 781 a, g dbSNP:774036261
783 783 a, g dbSNP:770427079
785 785 g, t dbSNP:762510331
789 789 c, t dbSNP:773146940
790 790 c, t dbSNP:752350267
795 795 c, t dbSNP:747936835
796 796 a, g dbSNP:780872438
799 799 c, t dbSNP:768621233

Target ORF information:

RefSeq Version NM_022559
Organism Homo sapiens (human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022559

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25687D
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product somatotropin isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, CD108592.1 and AV753220.1. On May 21, 2014 this sequence version replaced gi:20809250. Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD108592.1, CD106566.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2162568 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_072054.1
CDS77..610
Misc Feature(1)179..601(+)
Misc Feature(2)179..601(+)
Misc Feature(3)350..352(+)
Misc Feature(4)482..484(+)
Exon (1)1..86
Gene:GH1
Gene Synonym:
Exon (2)87..247
Gene:GH1
Gene Synonym:
Exon (3)248..412
Gene:GH1
Gene Synonym:
Exon (4)413..726
Gene:GH1
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:749272057
3 3 g, t dbSNP:774824249
4 4 a, g dbSNP:769351800
6 6 a, g dbSNP:745465815
9 9 a, g dbSNP:6171
14 14 a, c, t dbSNP:695
17 17 c, g dbSNP:6175
24 24 a, g dbSNP:370080186
30 30 a, g dbSNP:9282699
31 31 a, c dbSNP:777455884
34 34 a, c, t dbSNP:747695752
37 37 -, c dbSNP:755560241
37 37 c, t dbSNP:368843010
39 39 a, c dbSNP:6172
41 41 a, c dbSNP:751274337
47 47 a, g dbSNP:200562012
49 49 g, t dbSNP:757365673
50 50 g, t dbSNP:754099689
52 52 c, t dbSNP:757493647
54 54 g, t dbSNP:764482889
56 56 a, t dbSNP:760810115
62 62 g, t dbSNP:752877135
63 63 c, t dbSNP:767864638
67 67 a, c dbSNP:760090194
68 68 c, g dbSNP:774519450
72 72 c, t dbSNP:771309275
73 73 c, g, t dbSNP:6173
74 74 a, g dbSNP:772819563
76 76 a, g dbSNP:370696298
81 81 c, t dbSNP:111801128
83 83 a, c, g dbSNP:2001345
88 88 c, t dbSNP:146624652
91 91 c, t dbSNP:111957225
92 92 a, c, g, t dbSNP:140576665
93 93 a, g, t dbSNP:376469157
94 94 a, g dbSNP:749131325
96 96 a, c, t dbSNP:768782282
97 97 a, c, g, t dbSNP:61762496
100 100 c, t dbSNP:750918971
117 117 c, g dbSNP:372110326
124 124 c, g dbSNP:151294724
126 126 -, g dbSNP:752365662
127 127 c, t dbSNP:377278914
131 131 c, t dbSNP:376449159
135 135 a, g dbSNP:137853219
142 142 a, g dbSNP:754207595
154 154 a, c, t dbSNP:367600150
159 159 a, c dbSNP:760279051
160 160 a, g dbSNP:374895443
164 164 a, g dbSNP:767119011
165 165 c, t dbSNP:759181460
166 166 c, t dbSNP:774395504
167 167 c, g dbSNP:771037676
169 169 c, t dbSNP:762759144
170 170 g, t dbSNP:778910515
171 171 c, t dbSNP:772909638
177 177 a, g dbSNP:544000207
188 188 a, c, t dbSNP:780382626
190 190 c, g, t dbSNP:745988896
191 191 a, g dbSNP:779374598
192 192 c, t dbSNP:151263636
194 194 a, c dbSNP:754194422
197 197 c, t dbSNP:778008637
200 200 c, t dbSNP:71640273
201 201 a, g, t dbSNP:371953554
202 202 a, c, t dbSNP:751135936
203 203 a, g dbSNP:140787052
207 207 a, g dbSNP:754126557
209 209 a, c, t dbSNP:764929278
210 210 a, g dbSNP:71640274
211 211 c, t dbSNP:775659576
212 212 c, g dbSNP:772330168
213 213 c, t dbSNP:745903951
215 215 c, t dbSNP:145327622
221 221 c, g dbSNP:769678192
224 224 a, g dbSNP:544949394
226 226 ata, ctt dbSNP:386798325
226 226 a, c, g dbSNP:61735359
227 227 a, t dbSNP:778408321
228 228 a, t dbSNP:61735357
232 232 c, t dbSNP:577521176
236 236 c, t dbSNP:780939487
238 238 c, t dbSNP:754708691
239 239 c, t dbSNP:534146444
240 240 a, g dbSNP:751046106
247 247 c, t dbSNP:765998918
250 250 c, t dbSNP:768500322
251 251 a, c dbSNP:746780250
259 259 a, g dbSNP:557973956
263 263 c, t dbSNP:137853220
264 264 a, g dbSNP:757500095
270 270 c, g dbSNP:6174
272 272 c, t dbSNP:749511152
283 283 c, t dbSNP:139163836
284 284 c, g dbSNP:150761983
287 287 c, t dbSNP:752738695
288 288 c, t dbSNP:781692092
289 289 a, g dbSNP:71640278
295 295 g, t dbSNP:751860506
297 297 a, g dbSNP:766715590
301 301 c, g, t dbSNP:144610881
302 302 a, g, t dbSNP:377027593
305 305 a, c dbSNP:776036784
306 306 a, g dbSNP:142396035
308 308 c, t dbSNP:372776291
311 311 c, g dbSNP:775630395
313 313 c, g dbSNP:548995389
315 315 a, g dbSNP:368658744
319 319 a, c, g, t dbSNP:137882374
325 325 c, t dbSNP:748188371
326 326 a, g dbSNP:373958758
335 335 c, t dbSNP:755141415
337 337 a, g dbSNP:752055083
339 339 c, t dbSNP:780577159
343 343 a, c, t dbSNP:370785603
344 344 a, c, g dbSNP:201524858
346 346 c, t dbSNP:143833877
347 347 a, g dbSNP:753333968
352 352 g, t dbSNP:763501141
354 354 a, t dbSNP:199885167
359 359 a, g dbSNP:775540749
361 361 c, t dbSNP:41295041
362 362 a, g dbSNP:5388
364 364 c, t dbSNP:774017931
365 365 c, t dbSNP:769998616
369 369 a, g dbSNP:137853221
379 379 g, t dbSNP:748302020
380 380 a, g dbSNP:781542704
382 382 c, g dbSNP:768585995
391 391 a, t dbSNP:747139860
392 392 a, g, t dbSNP:758934916
402 402 c, t dbSNP:764140330
403 403 a, g dbSNP:41295043
406 406 c, g dbSNP:113379310
410 410 g, t dbSNP:753431488
412 412 g, t dbSNP:763850922
414 414 c, g dbSNP:755101832
415 415 a, g dbSNP:200925254
422 422 g, t dbSNP:770336766
423 423 a, t dbSNP:747795015
424 424 c, t dbSNP:201849388
426 426 a, g dbSNP:201165777
432 432 a, c, g dbSNP:41295253
434 434 c, t dbSNP:377600944
435 435 a, g, t dbSNP:41295255
436 436 c, g, t dbSNP:541629121
437 437 a, c, g dbSNP:572278056
443 443 a, c dbSNP:767778677
445 445 a, g dbSNP:759488326
449 449 c, t dbSNP:138880244
458 458 a, t dbSNP:771280061
462 462 a, g dbSNP:763500259
463 463 c, t dbSNP:773919353
469 469 a, g dbSNP:770248985
472 472 c, t dbSNP:4080075
473 473 a, g dbSNP:780941513
477 477 a, c dbSNP:768385118
481 481 a, c dbSNP:4080076
484 484 a, g dbSNP:397843499
486 486 a, g dbSNP:746437614
491 491 a, c, g dbSNP:151243538
495 495 a, c dbSNP:750357948
496 496 c, t dbSNP:753806390
497 497 a, g dbSNP:371051668
502 502 a, g dbSNP:4080078
503 503 c, t dbSNP:184640372
514 514 c, t dbSNP:753659458
515 515 a, g dbSNP:200409102
519 519 c, t dbSNP:759813905
523 523 c, t dbSNP:751783545
524 524 c, t dbSNP:766455056
529 529 c, t dbSNP:763012167
532 532 c, t dbSNP:571549544
541 541 c, g dbSNP:770439032
542 542 a, g dbSNP:762202654
553 553 c, g, t dbSNP:142704768
554 554 a, g dbSNP:373184101
568 568 c, t dbSNP:369176887
569 569 a, g dbSNP:771605458
570 570 g, t dbSNP:745438654
571 571 c, g, t dbSNP:148474991
574 574 g, t dbSNP:749039024
578 578 c, t dbSNP:777606230
581 581 c, t dbSNP:755905735
582 582 a, g dbSNP:137853223
583 583 c, g dbSNP:534831938
585 585 c, t dbSNP:766570969
592 592 a, g dbSNP:144550695
593 593 c, g dbSNP:750536547
598 598 c, t dbSNP:565832360
600 600 a, g dbSNP:375006135
602 602 a, g dbSNP:762433340
604 604 c, t dbSNP:777326685
611 611 c, g dbSNP:764487763
616 616 c, t dbSNP:761010486
617 617 a, g dbSNP:775193583
625 625 c, t dbSNP:771633757
626 626 a, c dbSNP:745307487
628 628 -, c dbSNP:772991248
634 634 c, t dbSNP:773878012
635 635 a, c, t dbSNP:749195779
636 636 a, c dbSNP:777642354
638 638 c, t dbSNP:755927336
643 643 a, g dbSNP:747910969
647 647 a, c dbSNP:201439757
650 650 c, t dbSNP:371688045
652 652 c, t dbSNP:750483022
657 657 a, c, t dbSNP:368234783
659 659 c, g dbSNP:754364357
662 662 -, g dbSNP:769939750
665 665 a, g, t dbSNP:761040508
666 666 g, t dbSNP:753006438
670 670 c, t dbSNP:767154356
687 687 a, g dbSNP:759204564
694 694 c, t dbSNP:755646836
706 706 a, g dbSNP:774036261
708 708 a, g dbSNP:770427079
710 710 g, t dbSNP:762510331
714 714 c, t dbSNP:773146940
715 715 c, t dbSNP:752350267
720 720 c, t dbSNP:747936835
721 721 a, g dbSNP:780872438
724 724 c, t dbSNP:768621233

Target ORF information:

RefSeq Version NM_022560
Organism Homo sapiens (human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022560

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.