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GHRHR cDNA ORF clone, Homo sapiens (human)

Gene Symbol GHRHR
Entrez Gene ID 2692
Full Name growth hormone releasing hormone receptor
Synonyms GHRFR, GRFR, IGHD1B
General protein information
Preferred Names
growth hormone-releasing hormone receptor
Names
growth hormone-releasing hormone receptor
GRF receptor
GHRH receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p14

Summary This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]. lac of sum
Disorder MIM:

139191

Disorder Html: Growth hormone deficiency, isolated, type IB, 612781 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000823 NP_000814 growth hormone-releasing hormone receptor precursor
XM_011515263 XP_011513565 growth hormone-releasing hormone receptor isoform X1



Homo sapiens (human) GHRHR NP_000814.2
Pan troglodytes (chimpanzee) GHRHR XP_519027.3
Canis lupus familiaris (dog) GHRHR XP_539502.3
Bos taurus (cattle) GHRHR NP_851363.1
Mus musculus (house mouse) Ghrhr NP_001003685.2
Rattus norvegicus (Norway rat) Ghrhr NP_036982.1
Gallus gallus (chicken) GHRHR NP_001032923.1
Danio rerio (zebrafish) ghrhrl NP_001075951.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GHRHR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GHRHR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18044 NM_000823 Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu57966 XM_011515263 PREDICTED: Homo sapiens growth hormone releasing hormone receptor (GHRHR), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18044
Clone ID Related Accession (Same CDS sequence) NM_000823
Accession Version NM_000823.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1272bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product growth hormone-releasing hormone receptor precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L09237.1 and DB348314.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2010 this sequence version replaced gi:58530850. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L01406.1, AY557192.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGACCGCC GGATGTGGGG GGCCCACGTC TTCTGCGTGT TGAGCCCGTT ACCGACCGTA 
TTGGGCCACA TGCACCCAGA ATGTGACTTC ATCACCCAGC TGAGAGAGGA TGAGAGTGCC
TGTCTACAAG CAGCAGAGGA GATGCCCAAC ACCACCCTGG GCTGCCCTGC GACCTGGGAT
GGGCTGCTGT GCTGGCCAAC GGCAGGCTCT GGCGAGTGGG TCACCCTCCC CTGCCCGGAT
TTCTTCTCTC ACTTCAGCTC AGAGTCAGGG GCTGTGAAAC GGGATTGTAC TATCACTGGC
TGGTCTGAGC CCTTTCCACC TTACCCTGTG GCCTGCCCTG TGCCTCTGGA GCTGCTGGCT
GAGGAGGAAT CTTACTTCTC CACAGTGAAG ATTATCTACA CCGTGGGCCA TAGCATCTCT
ATTGTAGCCC TCTTCGTGGC CATCACCATC CTGGTTGCTC TCAGGAGGCT CCACTGCCCC
CGGAACTACG TCCACACCCA GCTGTTCACC ACTTTTATCC TCAAGGCGGG AGCTGTGTTC
CTGAAGGATG CTGCCCTTTT CCACAGCGAC GACACTGACC ACTGCAGCTT CTCCACTGTT
CTATGCAAGG TCTCTGTGGC CGCCTCCCAT TTCGCCACCA TGACCAACTT CAGCTGGCTG
TTGGCAGAAG CCGTCTACCT GAACTGCCTC CTGGCCTCCA CCTCCCCCAG CTCAAGGAGA
GCCTTCTGGT GGCTGGTTCT CGCTGGCTGG GGGCTGCCCG TGCTCTTCAC TGGCACGTGG
GTGAGCTGCA AACTGGCCTT CGAGGACATC GCGTGCTGGG ACCTGGACGA CACCTCCCCC
TACTGGTGGA TCATCAAAGG GCCCATTGTC CTCTCGGTCG GGGTGAACTT TGGGCTTTTT
CTCAATATTA TCCGCATCCT GGTGAGGAAA CTGGAGCCAG CTCAGGGCAG CCTCCATACC
CAGTCTCAGT ATTGGCGTCT CTCCAAGTCG ACACTTTTCC TGATCCCACT CTTTGGAATT
CACTACATCA TCTTCAACTT CCTGCCAGAC AATGCTGGCC TGGGCATCCG CCTCCCCCTG
GAGCTGGGAC TGGGTTCCTT CCAGGGCTTC ATTGTTGCCA TCCTCTACTG CTTCCTCAAC
CAAGAGGTGA GGACTGAGAT CTCACGGAAG TGGCATGGCC ATGACCCTGA GCTTCTGCCA
GCCTGGAGGA CCCGTGCTAA GTGGACCACG CCTTCCCGCT CGGCGGCAAA GGTGCTGACA
TCTATGTGCT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000814.2
CDS49..1320
Misc Feature(1)202..384(+)
Misc Feature(2)424..1164(+)
Misc Feature(3)445..504(+)
Misc Feature(4)535..591(+)
Misc Feature(5)661..729(+)
Misc Feature(6)769..834(+)
Misc Feature(7)889..960(+)
Misc Feature(8)1036..1092(+)
Misc Feature(9)1132..1191(+)
Exon (1)1..105
Gene:GHRHR
Gene Synonym:
Exon (2)106..208
Gene:GHRHR
Gene Synonym:
Exon (3)209..316
Gene:GHRHR
Gene Synonym:
Exon (4)317..414
Gene:GHRHR
Gene Synonym:
Exon (5)415..512
Gene:GHRHR
Gene Synonym:
Exon (6)513..645
Gene:GHRHR
Gene Synonym:
Exon (7)646..799
Gene:GHRHR
Gene Synonym:
Exon (8)800..860
Gene:GHRHR
Gene Synonym:
Exon (9)861..930
Gene:GHRHR
Gene Synonym:
Exon (10)931..1022
Gene:GHRHR
Gene Synonym:
Exon (11)1023..1152
Gene:GHRHR
Gene Synonym:
Exon (12)1153..1194
Gene:GHRHR
Gene Synonym:
Exon (13)1195..1607
Gene:GHRHR
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000823
Organism Homo sapiens (human)
Definition Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000823

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGACCGCC GGATGTGGGG GGCCCACGTC TTCTGCGTGT TGAGCCCGTT ACCGACCGTA 
TTGGGCCACA TGCACCCAGA ATGTGACTTC ATCACCCAGC TGAGAGAGGA TGAGAGTGCC
TGTCTACAAG CAGCAGAGGA GATGCCCAAC ACCACCCTGG GCTGCCCTGC GACCTGGGAT
GGGCTGCTGT GCTGGCCAAC GGCAGGCTCT GGCGAGTGGG TCACCCTCCC CTGCCCGGAT
TTCTTCTCTC ACTTCAGCTC AGAGTCAGGG GCTGTGAAAC GGGATTGTAC TATCACTGGC
TGGTCTGAGC CCTTTCCACC TTACCCTGTG GCCTGCCCTG TGCCTCTGGA GCTGCTGGCT
GAGGAGGAAT CTTACTTCTC CACAGTGAAG ATTATCTACA CCGTGGGCCA TAGCATCTCT
ATTGTAGCCC TCTTCGTGGC CATCACCATC CTGGTTGCTC TCAGGAGGCT CCACTGCCCC
CGGAACTACG TCCACACCCA GCTGTTCACC ACTTTTATCC TCAAGGCGGG AGCTGTGTTC
CTGAAGGATG CTGCCCTTTT CCACAGCGAC GACACTGACC ACTGCAGCTT CTCCACTGTT
CTATGCAAGG TCTCTGTGGC CGCCTCCCAT TTCGCCACCA TGACCAACTT CAGCTGGCTG
TTGGCAGAAG CCGTCTACCT GAACTGCCTC CTGGCCTCCA CCTCCCCCAG CTCAAGGAGA
GCCTTCTGGT GGCTGGTTCT CGCTGGCTGG GGGCTGCCCG TGCTCTTCAC TGGCACGTGG
GTGAGCTGCA AACTGGCCTT CGAGGACATC GCGTGCTGGG ACCTGGACGA CACCTCCCCC
TACTGGTGGA TCATCAAAGG GCCCATTGTC CTCTCGGTCG GGGTGAACTT TGGGCTTTTT
CTCAATATTA TCCGCATCCT GGTGAGGAAA CTGGAGCCAG CTCAGGGCAG CCTCCATACC
CAGTCTCAGT ATTGGCGTCT CTCCAAGTCG ACACTTTTCC TGATCCCACT CTTTGGAATT
CACTACATCA TCTTCAACTT CCTGCCAGAC AATGCTGGCC TGGGCATCCG CCTCCCCCTG
GAGCTGGGAC TGGGTTCCTT CCAGGGCTTC ATTGTTGCCA TCCTCTACTG CTTCCTCAAC
CAAGAGGTGA GGACTGAGAT CTCACGGAAG TGGCATGGCC ATGACCCTGA GCTTCTGCCA
GCCTGGAGGA CCCGTGCTAA GTGGACCACG CCTTCCCGCT CGGCGGCAAA GGTGCTGACA
TCTATGTGCT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57966
Clone ID Related Accession (Same CDS sequence) XM_011515263
Accession Version XM_011515263.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1080bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product growth hormone-releasing hormone receptor isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007819.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGTCCCTG GCACCCCCAG CCCCCTCCTG GGGAGAGGGA AGGAGTTGTG GCTAGAGAGT 
CTTGCTTGCC TCCCAGGGGC TGTGAAACGG GATTGTACTA TCACTGGCTG GTCTGAGCCC
TTTCCACCTT ACCCTGTGGC CTGCCCTGTG CCTCTGGAGC TGCTGGCTGA GGAGGAATCT
TACTTCTCCA CAGTGAAGAT TATCTACACC GTGGGCCATA GCATCTCTAT TGTAGCCCTC
TTCGTGGCCA TCACCATCCT GGTTGCTCTC AGGAGGCTCC ACTGCCCCCG GAACTACGTC
CACACCCAGC TGTTCACCAC TTTTATCCTC AAGGCGGGAG CTGTGTTCCT GAAGGATGCT
GCCCTTTTCC ACAGCGACGA CACTGACCAC TGCAGCTTCT CCACTGTTCT ATGCAAGGTC
TCTGTGGCCG CCTCCCATTT CGCCACCATG ACCAACTTCA GCTGGCTGTT GGCAGAAGCC
GTCTACCTGA ACTGCCTCCT GGCCTCCACC TCCCCCAGCT CAAGGAGAGC CTTCTGGTGG
CTGGTTCTCG CTGGCTGGGG GCTGCCCGTG CTCTTCACTG GCACGTGGGT GAGCTGCAAA
CTGGCCTTCG AGGACATCGC GTGCTGGGAC CTGGACGACA CCTCCCCCTA CTGGTGGATC
ATCAAAGGGC CCATTGTCCT CTCGGTCGGG GTGAACTTTG GGCTTTTTCT CAATATTATC
CGCATCCTGG TGAGGAAACT GGAGCCAGCT CAGGGCAGCC TCCATACCCA GTCTCAGTAT
TGGCGTCTCT CCAAGTCGAC ACTTTTCCTG ATCCCACTCT TTGGAATTCA CTACATCATC
TTCAACTTCC TGCCAGACAA TGCTGGCCTG GGCATCCGCC TCCCCCTGGA GCTGGGACTG
GGTTCCTTCC AGGGCTTCAT TGTTGCCATC CTCTACTGCT TCCTCAACCA AGAGGTGAGG
ACTGAGATCT CACGGAAGTG GCATGGCCAT GACCCTGAGC TTCTGCCAGC CTGGAGGACC
CGTGCTAAGT GGACCACGCC TTCCCGCTCG GCGGCAAAGG TGCTGACATC TATGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011513565.1
CDS259..1338
Misc Feature(1)442..1182(+)
Translation

Target ORF information:

RefSeq Version XM_011515263
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens growth hormone releasing hormone receptor (GHRHR), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515263

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGTCCCTG GCACCCCCAG CCCCCTCCTG GGGAGAGGGA AGGAGTTGTG GCTAGAGAGT 
CTTGCTTGCC TCCCAGGGGC TGTGAAACGG GATTGTACTA TCACTGGCTG GTCTGAGCCC
TTTCCACCTT ACCCTGTGGC CTGCCCTGTG CCTCTGGAGC TGCTGGCTGA GGAGGAATCT
TACTTCTCCA CAGTGAAGAT TATCTACACC GTGGGCCATA GCATCTCTAT TGTAGCCCTC
TTCGTGGCCA TCACCATCCT GGTTGCTCTC AGGAGGCTCC ACTGCCCCCG GAACTACGTC
CACACCCAGC TGTTCACCAC TTTTATCCTC AAGGCGGGAG CTGTGTTCCT GAAGGATGCT
GCCCTTTTCC ACAGCGACGA CACTGACCAC TGCAGCTTCT CCACTGTTCT ATGCAAGGTC
TCTGTGGCCG CCTCCCATTT CGCCACCATG ACCAACTTCA GCTGGCTGTT GGCAGAAGCC
GTCTACCTGA ACTGCCTCCT GGCCTCCACC TCCCCCAGCT CAAGGAGAGC CTTCTGGTGG
CTGGTTCTCG CTGGCTGGGG GCTGCCCGTG CTCTTCACTG GCACGTGGGT GAGCTGCAAA
CTGGCCTTCG AGGACATCGC GTGCTGGGAC CTGGACGACA CCTCCCCCTA CTGGTGGATC
ATCAAAGGGC CCATTGTCCT CTCGGTCGGG GTGAACTTTG GGCTTTTTCT CAATATTATC
CGCATCCTGG TGAGGAAACT GGAGCCAGCT CAGGGCAGCC TCCATACCCA GTCTCAGTAT
TGGCGTCTCT CCAAGTCGAC ACTTTTCCTG ATCCCACTCT TTGGAATTCA CTACATCATC
TTCAACTTCC TGCCAGACAA TGCTGGCCTG GGCATCCGCC TCCCCCTGGA GCTGGGACTG
GGTTCCTTCC AGGGCTTCAT TGTTGCCATC CTCTACTGCT TCCTCAACCA AGAGGTGAGG
ACTGAGATCT CACGGAAGTG GCATGGCCAT GACCCTGAGC TTCTGCCAGC CTGGAGGACC
CGTGCTAAGT GGACCACGCC TTCCCGCTCG GCGGCAAAGG TGCTGACATC TATGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size but not density of trabecular and mixed bone
J. Clin. Endocrinol. Metab. 98 (11), E1710-E1715 (2013)
Epitacio-Pereira CC, Silva GM, Salvatori R, Santana JA, Pereira FA, Gois-Junior MB, Britto AV, Oliveira CR, Souza AH, Santos EG, Campos VC, Pereira RM, Valenca EH, Barbosa RA, Farias MI, de Paula FJ, Ribeiro TV, Oliveira MC and Aguiar-Oliveira MH.


book

Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs
Proc. Natl. Acad. Sci. U.S.A. 99 (1), 196-200 (2002)
Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S and Varga JL.


book

Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers
Proc. Natl. Acad. Sci. U.S.A. 97 (19), 10561-10566 (2000)
Rekasi Z, Czompoly T, Schally AV and Halmos G.


book

Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh
J. Clin. Endocrinol. Metab. 83 (11), 4065-4074 (1998)
Maheshwari HG, Silverman BL, Dupuis J and Baumann G.


book

Structure and regulation of the human growth hormone-releasing hormone receptor gene
Mol. Endocrinol. 12 (2), 233-247 (1998)
Petersenn S, Rasch AC, Heyens M and Schulte HM.


book

Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
Nat. Genet. 12 (1), 88-90 (1996)
Wajnrajch MP, Gertner JM, Harbison MD, Chua SC Jr and Leibel RL.


book

Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas
J. Clin. Endocrinol. Metab. 80 (10), 2933-2939 (1995)
Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B and Kishimoto T.


book

Identification of human growth hormone-releasing hormone receptor splicing variants
J. Clin. Endocrinol. Metab. 80 (8), 2381-2387 (1995)
Tang J, Lagace G, Castagne J and Collu R.


book

Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization
Genomics 19 (1), 193-195 (1994)
Gaylinn BD, von Kap-Herr C, Golden WL and Thorner MO.


book

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone
Mol. Endocrinol. 6 (10), 1734-1744 (1992)
Mayo KE.


 
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