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UQCRQ cDNA ORF clone, Homo sapiens (human)

Gene Symbol UQCRQ
Entrez Gene ID 27089
Full Name ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Synonyms MC3DN4, QCR8, QP-C, QPC, UQCR7
General protein information
Preferred Names
cytochrome b-c1 complex subunit 8
Names
cytochrome b-c1 complex subunit 8
complex III subunit 8
complex III subunit VIII
low molecular mass ubiquinone-binding protein (9.5kD)
ubiquinol-cytochrome c reductase complex 9.5 kDa protein
ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
NP_055217.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31.1

Summary This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

612080

Disorder Html: Mitochondrial complex III deficiency, 124000 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_014402 NP_055217 cytochrome b-c1 complex subunit 8



Homo sapiens (human) UQCRQ NP_055217.2
Pan troglodytes (chimpanzee) UQCRQ XP_527009.2
Macaca mulatta (Rhesus monkey) LOC695665 XP_001085732.1
Canis lupus familiaris (dog) UQCRQ XP_852164.1
Bos taurus (cattle) UQCRQ NP_777230.1
Mus musculus (house mouse) Uqcrq NP_079628.1
Rattus norvegicus (Norway rat) Uqcrq NP_001020305.1
Gallus gallus (chicken) UQCRQ XP_414651.1
Gallus gallus (chicken) LOC100858114 XP_003642138.1
Danio rerio (zebrafish) uqcrq NP_001002495.2
Drosophila melanogaster (fruit fly) CG7580 NP_001189125.1
Xenopus (Silurana) tropicalis (western clawed frog) uqcrq NP_001016654.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following UQCRQ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCRQ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27789
NM_014402 Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa (UQCRQ), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27789
Clone ID Related Accession (Same CDS sequence) NM_014402
Accession Version NM_014402.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cytochrome b-c1 complex subunit 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU953465.1, CR743513.1, BU190580.1 and AC004500.1. This sequence is a reference standard in the RefSeqGene project. On May 19, 2006 this sequence version replaced gi:83367082. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BP294955.1, AU119402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT
GACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_055217.2
CDS75..323
Misc Feature(1)54..56(+)
Misc Feature(2)78..317(+)
Exon (1)1..61
Gene:UQCRQ
Gene Synonym:
Exon (2)62..228
Gene:UQCRQ
Gene Synonym:
Exon (3)229..1585
Gene:UQCRQ
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014402
Organism Homo sapiens (human)
Definition Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa (UQCRQ), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014402

ORF Insert Sequence:

1
61
121
181
241
ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT
GACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis
Mol. Cell. Biochem. 342 (1-2), 111-115 (2010)
Sifroni KG, Damiani CR, Stoffel C, Cardoso MR, Ferreira GK, Jeremias IC, Rezin GT, Scaini G, Schuck PF, Dal-Pizzol F and Streck EL.


book

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression
PLoS ONE 5 (9), E12862 (2010)
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL and O'Brien SJ.


book

Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ
Am. J. Hum. Genet. 82 (5), 1211-1216 (2008)
Barel O, Shorer Z, Flusser H, Ofir R, Narkis G, Finer G, Shalev H, Nasasra A, Saada A and Birk OS.


book

Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection
Free Radic. Biol. Med. 37 (12), 2072-2081 (2004)
Wen JJ and Garg N.


book

Ubiquinol-cytochrome-c reductase from human and bovine mitochondria
Meth. Enzymol. 260, 82-96 (1995)
Schagger H, Brandt U, Gencic S and von Jagow G.


book

The small molecular mass ubiquinone-binding protein (QPc-9.5 kDa) in mitochondrial ubiquinol-cytochrome c reductase: isolation, ubiquinone-binding domain, and immunoinhibition
Biochemistry 29 (19), 4618-4626 (1990)
Usui S, Yu L and Yu CA.


 
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