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GM2A cDNA ORF clone, Homo sapiens (human)

Gene Symbol GM2A
Entrez Gene ID 2760
Full Name GM2 ganglioside activator
Synonyms GM2-AP, SAP-3
General protein information
Preferred Names
ganglioside GM2 activator
Names
ganglioside GM2 activator
shingolipid activator protein 3
sphingolipid activator protein 3
cerebroside sulfate activator protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33.1

Summary This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. lac of sum
Disorder MIM:

613109

Disorder Html: GM2-gangliosidosis, AB variant, 272750 (3)





The following GM2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GM2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26321 NM_000405 Homo sapiens GM2 ganglioside activator (GM2A), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00
OHu27665 NM_001167607 Homo sapiens GM2 ganglioside activator (GM2A), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu26321
Accession Version NM_000405.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 582bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ganglioside GM2 activator isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM834780.1, X61095.1 and AC008385.7. This sequence is a reference standard in the RefSeqGene project. On May 24, 2008 this sequence version replaced gi:39995108. Summary: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X62078.1, BC009273.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGCAGTCCC TGATGCAGGC TCCCCTCCTG ATCGCCCTGG GCTTGCTTCT CGCGGCCCCT 
GCGCAAGCCC ACCTGAAAAA GCCATCCCAG CTCAGTAGCT TTTCCTGGGA TAACTGTGAT
GAAGGGAAGG ACCCTGCGGT GATCAGAAGC CTGACTCTGG AGCCTGACCC CATCATCGTT
CCTGGAAATG TGACCCTCAG TGTCATGGGC AGCACCAGTG TCCCCCTGAG TTCTCCTCTG
AAGGTGGATT TAGTTTTGGA GAAGGAGGTG GCTGGCCTCT GGATCAAGAT CCCATGCACA
GACTACATTG GCAGCTGTAC CTTTGAACAC TTCTGTGATG TGCTTGACAT GTTAATTCCT
ACTGGGGAGC CCTGCCCAGA GCCCCTGCGT ACCTATGGGC TTCCTTGCCA CTGTCCCTTC
AAAGAAGGAA CCTACTCACT GCCCAAGAGC GAATTCGTTG TGCCTGACCT GGAGCTGCCC
AGTTGGCTCA CCACCGGGAA CTACCGCATA GAGAGCGTCC TGAGCAGCAG TGGGAAGCGT
CTGGGCTGCA TCAAGATCGC TGCCTCTCTA AAGGGCATAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000396.2
CDS166..747
Misc Feature(1)139..141(+)
Misc Feature(2)259..744(+)
Misc Feature(3)265..735(+)
Misc Feature(4)280..714(+)
Misc Feature(5)460..483(+)
Misc Feature(6)499..579(+)
Misc Feature(7)538..573(+)
Exon (1)1..246
Gene:GM2A
Gene Synonym:
Exon (2)247..408
Gene:GM2A
Gene Synonym:
Exon (3)409..591
Gene:GM2A
Gene Synonym:
Exon (4)592..3690
Gene:GM2A
Gene Synonym:
Translation
Position Chain Variation Link
64 64 a, g dbSNP:2277028
122 122 a, g dbSNP:144932594
124 124 c, t dbSNP:751233771
125 125 a, t dbSNP:1048718
128 128 a, g dbSNP:367935217
135 135 c, g, t dbSNP:553449209
144 144 c, g, t dbSNP:755584488
148 148 c, t dbSNP:749782834
157 157 -, c dbSNP:756968170
159 159 a, c dbSNP:371628812
164 164 a, c, g dbSNP:572025687
167 167 c, t dbSNP:772342276
169 169 c, t dbSNP:775585062
170 170 a, g, t dbSNP:562249526
173 173 c, t dbSNP:545467021
176 176 c, t dbSNP:762676667
177 177 c, g dbSNP:766243967
178 178 a, t dbSNP:557461469
179 179 c, t dbSNP:759249002
180 180 a, g dbSNP:764022141
181 181 c, g dbSNP:767131690
189 189 c, g dbSNP:752323907
192 192 a, c, t dbSNP:760185979
198 198 c, t dbSNP:143867953
199 199 g, t dbSNP:543252624
204 204 a, g dbSNP:374161170
210 210 g, t dbSNP:779239922
220 220 a, g dbSNP:1048719
221 221 c, g dbSNP:200545376
222 222 c, g dbSNP:780278367
228 228 g, t dbSNP:529126687
234 234 c, g, t dbSNP:768756904
243 243 a, t dbSNP:28365994
251 251 c, t dbSNP:770025057
255 255 g, t dbSNP:371296403
257 257 c, t dbSNP:745850680
260 260 a, g dbSNP:139369020
265 265 c, t dbSNP:775218532
275 275 -, t dbSNP:779969671
275 275 a, g dbSNP:760365843
291 291 a, g dbSNP:113271740
298 298 a, c dbSNP:375909851
302 302 c, t dbSNP:761268810
303 303 a, g dbSNP:147511920
307 307 a, t dbSNP:773683744
314 314 a, g dbSNP:763407122
318 318 c, g dbSNP:766759666
325 325 g, t dbSNP:104893897
329 329 c, t dbSNP:730882196
337 337 a, g dbSNP:755382727
338 338 c, t dbSNP:767781109
339 339 c, t dbSNP:752989938
340 340 a, g dbSNP:153477
341 341 c, t dbSNP:778041179
342 342 c, t dbSNP:745799277
343 343 a, g, t dbSNP:201829650
344 344 a, t dbSNP:761513426
347 347 c, g dbSNP:141199254
360 360 a, c dbSNP:768523926
369 369 a, c dbSNP:776214439
370 370 a, g dbSNP:153478
371 371 c, t dbSNP:769261253
387 387 c, t dbSNP:772774529
391 391 a, c dbSNP:763502453
395 395 a, g dbSNP:201633382
398 398 -, ctc dbSNP:749309977
409 409 a, c, g dbSNP:139014924
419 419 g, t dbSNP:143999954
422 422 c, t dbSNP:772562842
426 426 a, g dbSNP:201066568
433 433 c, g dbSNP:202199250
437 437 c, t dbSNP:761137594
451 451 a, g dbSNP:764348335
456 456 c, g, t dbSNP:754125210
459 459 a, g dbSNP:765404263
461 461 a, g dbSNP:751417546
472 472 a, c dbSNP:754972474
486 486 c, t dbSNP:780949321
492 492 a, g dbSNP:752430956
498 498 -, c dbSNP:587779405
500 500 g, t dbSNP:773743799
503 503 a, t dbSNP:761316539
504 504 c, t dbSNP:202019098
507 507 g, t dbSNP:777250593
511 511 c, g dbSNP:145111469
526 526 a, g dbSNP:770317166
540 540 c, t dbSNP:778553529
541 541 c, g dbSNP:746349677
549 549 a, c, g dbSNP:772651186
553 553 c, t dbSNP:761084552
554 554 a, g dbSNP:769169088
559 559 c, t dbSNP:776691770
560 560 a, g, t dbSNP:762131629
567 567 g, t dbSNP:750572499
575 575 a, g dbSNP:763032791
577 577 c, t dbSNP:137852797
580 580 a, c, t dbSNP:767374072
583 583 g, t dbSNP:755853603
593 593 a, g dbSNP:757954770
596 596 c, t dbSNP:779755266
611 611 a, g dbSNP:375238641
615 615 c, t dbSNP:755569739
616 616 a, g, t dbSNP:747270491
621 621 c, t dbSNP:748480601
622 622 a, g dbSNP:200807411
623 623 c, t dbSNP:61740602
634 634 c, t dbSNP:773374982
639 639 a, g dbSNP:749561056
640 640 a, c dbSNP:770993371
657 657 c, g dbSNP:774471512
660 660 c, t dbSNP:759623712
661 661 a, g dbSNP:764022955
668 668 a, g dbSNP:564534389
670 670 a, c, t dbSNP:761616890
671 671 a, c, g dbSNP:104893892
672 672 c, t dbSNP:148886884
673 673 a, g dbSNP:758195639
676 676 a, g dbSNP:765976514
678 678 c, g dbSNP:751058268
681 681 c, t dbSNP:754452771
682 682 a, c, g dbSNP:532003642
685 685 c, g dbSNP:756479716
687 687 c, g dbSNP:778176491
693 693 c, g dbSNP:749497621
703 703 c, t dbSNP:771081390
704 704 a, c, g dbSNP:368576623
716 716 a, t dbSNP:199774853
723 723 c, t dbSNP:776606375
728 728 c, g dbSNP:761692942
729 729 c, g, t dbSNP:567701178
730 730 c, t dbSNP:762858957
735 735 a, g dbSNP:766065261
740 740 a, g, t dbSNP:751291017
744 744 a, g dbSNP:766986799
747 747 a, g, t dbSNP:1048723
749 749 a, g dbSNP:756637678
750 750 c, t dbSNP:778266121
774 774 a, g dbSNP:754133078
775 775 c, t dbSNP:9324685
776 776 a, g dbSNP:372056444
798 798 c, t dbSNP:746123189
812 812 g, t dbSNP:772155389
814 814 c, t dbSNP:565719946
833 833 c, t dbSNP:748106664
838 838 a, c dbSNP:774301017
840 840 c, g dbSNP:773289608
841 841 c, g dbSNP:762798717
847 847 a, g dbSNP:770872418
891 891 c, t dbSNP:9324686
896 896 a, t dbSNP:759152227
904 904 c, t dbSNP:375810746
905 905 a, g dbSNP:767039864
912 912 g, t dbSNP:369948657
913 913 c, t dbSNP:760181457
916 916 g, t dbSNP:764543724
927 927 c, t dbSNP:754361992
939 939 a, g dbSNP:147601669
952 952 a, g dbSNP:576877017
967 967 c, t dbSNP:372430796
973 973 c, t dbSNP:537947985
974 974 a, g dbSNP:989
978 978 a, g dbSNP:148662528
981 981 -, gggctg dbSNP:570818011
984 984 c, t dbSNP:780339678
988 988 c, t dbSNP:377505668
992 992 a, g dbSNP:542291291
1001 1001 -, c dbSNP:573098884
1001 1001 c, g dbSNP:554213467
1002 1002 c, t dbSNP:75026189
1004 1004 -, c dbSNP:376979280
1004 1004 c, t dbSNP:536229935
1005 1005 a, g dbSNP:760474662
1033 1033 c, t dbSNP:766120281
1078 1078 a, c dbSNP:545996986
1099 1099 c, g dbSNP:564679676
1103 1103 a, c dbSNP:189626755
1108 1108 a, t dbSNP:1048724
1111 1111 -, c dbSNP:201142293
1112 1112 -, t dbSNP:35295884
1113 1113 -, t dbSNP:560122101
1122 1122 -, t dbSNP:398084556
1123 1123 g, t dbSNP:78108878
1123 1123 -, t dbSNP:397712620
1141 1141 c, g dbSNP:574467377
1148 1148 a, g dbSNP:116809628
1157 1157 c, t dbSNP:181890739
1158 1158 a, g dbSNP:375874064
1173 1173 c, t dbSNP:370699960
1283 1283 g, t dbSNP:151210034
1299 1299 a, g dbSNP:546945897
1316 1316 g, t dbSNP:765695789
1326 1326 a, c dbSNP:748208365
1337 1337 g, t dbSNP:374360638
1376 1376 c, t dbSNP:184763035
1387 1387 c, g dbSNP:533014440
1407 1407 a, c dbSNP:758698792
1416 1416 a, g dbSNP:140405440
1434 1434 a, c dbSNP:143552628
1451 1451 a, t dbSNP:569818818
1457 1457 -, t, tt dbSNP:35982513
1457 1457 c, t dbSNP:202239462
1470 1470 -, t dbSNP:397884529
1471 1471 c, g dbSNP:112641014
1471 1471 g, tc dbSNP:370553515
1537 1537 c, t dbSNP:181571430
1549 1549 a, t dbSNP:558475439
1571 1571 a, c dbSNP:186626408
1604 1604 c, t dbSNP:751625171
1607 1607 c, t dbSNP:368971605
1609 1609 c, t dbSNP:781320720
1611 1611 c, t dbSNP:191120902
1670 1670 c, t dbSNP:534926050
1685 1685 a, g dbSNP:1130163
1687 1687 g, t dbSNP:572376253
1691 1691 c, t dbSNP:149174
1713 1713 c, t dbSNP:558009105
1714 1714 a, g dbSNP:748159813
1760 1760 c, t dbSNP:15860
1761 1761 -, t dbSNP:35568032
1805 1805 a, g dbSNP:772135107
1815 1815 a, g dbSNP:576574973
1823 1823 a, g dbSNP:543560957
1939 1939 g, t dbSNP:562785409
1977 1977 -, a dbSNP:35654352
1977 1977 a, c dbSNP:201288211
1986 1986 -, a dbSNP:397883774
1988 1988 c, t dbSNP:541818620
1993 1993 a, g dbSNP:760209124
2018 2018 a, g, t dbSNP:200856540
2019 2019 -, c dbSNP:35550113
2019 2019 c, t dbSNP:201799049
2020 2020 -, c dbSNP:397792840
2021 2021 -, c dbSNP:397716595
2059 2059 g, t dbSNP:541345989
2127 2127 c, g dbSNP:770712692
2149 2149 c, g dbSNP:146782771
2155 2155 g, t dbSNP:532825835
2157 2157 a, c dbSNP:181014044
2192 2192 a, g dbSNP:153450
2221 2221 a, g dbSNP:530626896
2227 2227 a, g dbSNP:552596465
2228 2228 g, t dbSNP:11262
2309 2309 c, t dbSNP:185065661
2328 2328 c, t dbSNP:534887805
2341 2341 a, g dbSNP:546611992
2412 2412 a, g dbSNP:570980806
2442 2442 a, c dbSNP:115956086
2464 2464 c, t dbSNP:539494761
2519 2519 a, t dbSNP:140540848
2528 2528 a, t dbSNP:191050130
2576 2576 c, t dbSNP:3806952
2588 2588 g, t dbSNP:555509927
2594 2594 a, g dbSNP:532326227
2602 2602 a, g dbSNP:773887985
2611 2611 a, c dbSNP:371212055
2613 2613 c, t dbSNP:3806953
2654 2654 a, g dbSNP:372489813
2697 2697 g, t dbSNP:763507795
2741 2741 a, g dbSNP:12516391
2772 2772 c, g dbSNP:577565833
2817 2817 a, g dbSNP:568732529
2854 2854 c, t dbSNP:544633353
2888 2888 c, t dbSNP:153449
2947 2947 c, t dbSNP:145689253
2948 2948 a, g dbSNP:375679727
2962 2962 a, t dbSNP:561047446
2981 2981 a, c dbSNP:528335575
3000 3000 c, g dbSNP:554614171
3010 3010 a, g dbSNP:755517801
3043 3043 a, g dbSNP:546869021
3048 3048 c, t dbSNP:571403858
3100 3100 g, t dbSNP:532444060
3110 3110 c, t dbSNP:566427956
3177 3177 c, t dbSNP:3734041
3178 3178 a, g dbSNP:569734211
3200 3200 c, t dbSNP:750703170
3222 3222 a, g dbSNP:533895518
3227 3227 a, g dbSNP:756257410
3266 3266 a, g dbSNP:138240164
3271 3271 c, t dbSNP:149180405
3276 3276 a, g dbSNP:747946670
3294 3294 a, g dbSNP:567034017
3331 3331 a, g dbSNP:113128701
3334 3334 c, t dbSNP:567514360
3366 3366 c, t dbSNP:772153529
3384 3384 c, t dbSNP:576999561
3388 3388 c, g dbSNP:777790635
3389 3389 c, t dbSNP:534955137
3390 3390 a, g, t dbSNP:114108271
3436 3436 -, t dbSNP:34492898
3442 3442 a, g dbSNP:770518416
3446 3446 -, t dbSNP:774921338
3446 3446 a, g dbSNP:183242789
3460 3460 -, taa dbSNP:201627590
3461 3461 -, aata dbSNP:143203938
3464 3464 -, aaat dbSNP:35384604
3464 3464 a, g dbSNP:200150752
3514 3514 c, t dbSNP:117832237
3547 3547 c, t dbSNP:575340052
3548 3548 a, g dbSNP:111935946
3560 3560 a, g dbSNP:745598662
3572 3572 a, g dbSNP:561012055
3586 3586 c, t dbSNP:769315888
3596 3596 a, g dbSNP:10076053
3618 3618 c, t dbSNP:540012441
3627 3627 a, g dbSNP:565102108
3638 3638 a, t dbSNP:763236680
3643 3643 c, t dbSNP:143342609
3685 3685 a, g dbSNP:764611573

Target ORF information:

RefSeq Version NM_000405
Organism Homo sapiens (human)
Definition Homo sapiens GM2 ganglioside activator (GM2A), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000405

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCAGTCCC TGATGCAGGC TCCCCTCCTG ATCGCCCTGG GCTTGCTTCT CGCGGCCCCT 
GCGCAAGCCC ACCTGAAAAA GCCATCCCAG CTCAGTAGCT TTTCCTGGGA TAACTGTGAT
GAAGGGAAGG ACCCTGCGGT GATCAGAAGC CTGACTCTGG AGCCTGACCC CATCATCGTT
CCTGGAAATG TGACCCTCAG TGTCATGGGC AGCACCAGTG TCCCCCTGAG TTCTCCTCTG
AAGGTGGATT TAGTTTTGGA GAAGGAGGTG GCTGGCCTCT GGATCAAGAT CCCATGCACA
GACTACATTG GCAGCTGTAC CTTTGAACAC TTCTGTGATG TGCTTGACAT GTTAATTCCT
ACTGGGGAGC CCTGCCCAGA GCCCCTGCGT ACCTATGGGC TTCCTTGCCA CTGTCCCTTC
AAAGAAGGAA CCTACTCACT GCCCAAGAGC GAATTCGTTG TGCCTGACCT GGAGCTGCCC
AGTTGGCTCA CCACCGGGAA CTACCGCATA GAGAGCGTCC TGAGCAGCAG TGGGAAGCGT
CTGGGCTGCA TCAAGATCGC TGCCTCTCTA AAGGGCATAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27665
Accession Version NM_001167607.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 561bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ganglioside GM2 activator isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008385.7. Summary: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298867.1, DC366588.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGCAGTCCC TGATGCAGGC TCCCCTCCTG ATCGCCCTGG GCTTGCTTCT CGCGGCCCCT 
GCGCAAGCCC ACCTGAAAAA GCCATCCCAG CTCAGTAGCT TTTCCTGGGA TAACTGTGAT
GAAGGGAAGG ACCCTGCGGT GATCAGAAGC CTGACTCTGG AGCCTGACCC CATCATCGTT
CCTGGAAATG TGACCCTCAG TGTCATGGGC AGCACCAGTG TCCCCCTGAG TTCTCCTCTG
AAGGTGGATT TAGTTTTGGA GAAGGAGGTG GCTGGCCTCT GGATCAAGAT CCCATGCACA
GACTACATTG GCAGCTGTAC CTTTGAACAC TTCTGTGATG TGCTTGACAT GTTAATTCCT
ACTGGGGAGC CCTGCCCAGA GCCCCTGCGT ACCTATGGGC TTCCTTGCCA CTGTCCCTTT
TCCTCTGTTT TGTGTTTGCC AAGGCCAAAC TCCCACTCTC TGCCCCCCTT TAATCCCCTT
TCTACAGTGA GTCCACTACC CTCACTGAAA ATCATTTTGT ACCACTTACA TTTTAGGCTG
GGGCAAGCAG CCCTGACCTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001161079.1
CDS166..726
Misc Feature(1)139..141(+)
Misc Feature(2)259..>585(+)
Misc Feature(3)271..585(+)
Exon (1)1..246
Gene:GM2A
Gene Synonym:
Exon (2)247..408
Gene:GM2A
Gene Synonym:
Exon (3)409..577
Gene:GM2A
Gene Synonym:
Exon (4)578..3480
Gene:GM2A
Gene Synonym:
Translation
Position Chain Variation Link
64 64 a, g dbSNP:2277028
122 122 a, g dbSNP:144932594
124 124 c, t dbSNP:751233771
125 125 a, t dbSNP:1048718
128 128 a, g dbSNP:367935217
135 135 c, g, t dbSNP:553449209
144 144 c, g, t dbSNP:755584488
148 148 c, t dbSNP:749782834
157 157 -, c dbSNP:756968170
159 159 a, c dbSNP:371628812
164 164 a, c, g dbSNP:572025687
167 167 c, t dbSNP:772342276
169 169 c, t dbSNP:775585062
170 170 a, g, t dbSNP:562249526
173 173 c, t dbSNP:545467021
176 176 c, t dbSNP:762676667
177 177 c, g dbSNP:766243967
178 178 a, t dbSNP:557461469
179 179 c, t dbSNP:759249002
180 180 a, g dbSNP:764022141
181 181 c, g dbSNP:767131690
189 189 c, g dbSNP:752323907
192 192 a, c, t dbSNP:760185979
198 198 c, t dbSNP:143867953
199 199 g, t dbSNP:543252624
204 204 a, g dbSNP:374161170
210 210 g, t dbSNP:779239922
220 220 a, g dbSNP:1048719
221 221 c, g dbSNP:200545376
222 222 c, g dbSNP:780278367
228 228 g, t dbSNP:529126687
234 234 c, g, t dbSNP:768756904
243 243 a, t dbSNP:28365994
251 251 c, t dbSNP:770025057
255 255 g, t dbSNP:371296403
257 257 c, t dbSNP:745850680
260 260 a, g dbSNP:139369020
265 265 c, t dbSNP:775218532
275 275 -, t dbSNP:779969671
275 275 a, g dbSNP:760365843
291 291 a, g dbSNP:113271740
298 298 a, c dbSNP:375909851
302 302 c, t dbSNP:761268810
303 303 a, g dbSNP:147511920
307 307 a, t dbSNP:773683744
314 314 a, g dbSNP:763407122
318 318 c, g dbSNP:766759666
325 325 g, t dbSNP:104893897
329 329 c, t dbSNP:730882196
337 337 a, g dbSNP:755382727
338 338 c, t dbSNP:767781109
339 339 c, t dbSNP:752989938
340 340 a, g dbSNP:153477
341 341 c, t dbSNP:778041179
342 342 c, t dbSNP:745799277
343 343 a, g, t dbSNP:201829650
344 344 a, t dbSNP:761513426
347 347 c, g dbSNP:141199254
360 360 a, c dbSNP:768523926
369 369 a, c dbSNP:776214439
370 370 a, g dbSNP:153478
371 371 c, t dbSNP:769261253
387 387 c, t dbSNP:772774529
391 391 a, c dbSNP:763502453
395 395 a, g dbSNP:201633382
398 398 -, ctc dbSNP:749309977
409 409 a, c, g dbSNP:139014924
419 419 g, t dbSNP:143999954
422 422 c, t dbSNP:772562842
426 426 a, g dbSNP:201066568
433 433 c, g dbSNP:202199250
437 437 c, t dbSNP:761137594
451 451 a, g dbSNP:764348335
456 456 c, g, t dbSNP:754125210
459 459 a, g dbSNP:765404263
461 461 a, g dbSNP:751417546
472 472 a, c dbSNP:754972474
486 486 c, t dbSNP:780949321
492 492 a, g dbSNP:752430956
498 498 -, c dbSNP:587779405
500 500 g, t dbSNP:773743799
503 503 a, t dbSNP:761316539
504 504 c, t dbSNP:202019098
507 507 g, t dbSNP:777250593
511 511 c, g dbSNP:145111469
526 526 a, g dbSNP:770317166
540 540 c, t dbSNP:778553529
541 541 c, g dbSNP:746349677
549 549 a, c, g dbSNP:772651186
553 553 c, t dbSNP:761084552
554 554 a, g dbSNP:769169088
559 559 c, t dbSNP:776691770
560 560 a, g, t dbSNP:762131629
567 567 g, t dbSNP:750572499
575 575 a, g dbSNP:763032791
577 577 c, t dbSNP:137852797
588 588 c, t dbSNP:746123189
602 602 g, t dbSNP:772155389
604 604 c, t dbSNP:565719946
623 623 c, t dbSNP:748106664
628 628 a, c dbSNP:774301017
630 630 c, g dbSNP:773289608
631 631 c, g dbSNP:762798717
637 637 a, g dbSNP:770872418
681 681 c, t dbSNP:9324686
686 686 a, t dbSNP:759152227
694 694 c, t dbSNP:375810746
695 695 a, g dbSNP:767039864
702 702 g, t dbSNP:369948657
703 703 c, t dbSNP:760181457
706 706 g, t dbSNP:764543724
717 717 c, t dbSNP:754361992
729 729 a, g dbSNP:147601669
742 742 a, g dbSNP:576877017
757 757 c, t dbSNP:372430796
763 763 c, t dbSNP:537947985
764 764 a, g dbSNP:989
768 768 a, g dbSNP:148662528
771 771 -, gggctg dbSNP:570818011
774 774 c, t dbSNP:780339678
778 778 c, t dbSNP:377505668
782 782 a, g dbSNP:542291291
791 791 -, c dbSNP:573098884
791 791 c, g dbSNP:554213467
792 792 c, t dbSNP:75026189
794 794 -, c dbSNP:376979280
794 794 c, t dbSNP:536229935
795 795 a, g dbSNP:760474662
823 823 c, t dbSNP:766120281
868 868 a, c dbSNP:545996986
889 889 c, g dbSNP:564679676
893 893 a, c dbSNP:189626755
898 898 a, t dbSNP:1048724
901 901 -, c dbSNP:201142293
902 902 -, t dbSNP:35295884
903 903 -, t dbSNP:560122101
912 912 -, t dbSNP:398084556
913 913 g, t dbSNP:78108878
913 913 -, t dbSNP:397712620
931 931 c, g dbSNP:574467377
938 938 a, g dbSNP:116809628
947 947 c, t dbSNP:181890739
948 948 a, g dbSNP:375874064
963 963 c, t dbSNP:370699960
1073 1073 g, t dbSNP:151210034
1089 1089 a, g dbSNP:546945897
1106 1106 g, t dbSNP:765695789
1116 1116 a, c dbSNP:748208365
1127 1127 g, t dbSNP:374360638
1166 1166 c, t dbSNP:184763035
1177 1177 c, g dbSNP:533014440
1197 1197 a, c dbSNP:758698792
1206 1206 a, g dbSNP:140405440
1224 1224 a, c dbSNP:143552628
1241 1241 a, t dbSNP:569818818
1247 1247 -, t, tt dbSNP:35982513
1247 1247 c, t dbSNP:202239462
1260 1260 -, t dbSNP:397884529
1261 1261 c, g dbSNP:112641014
1261 1261 g, tc dbSNP:370553515
1327 1327 c, t dbSNP:181571430
1339 1339 a, t dbSNP:558475439
1361 1361 a, c dbSNP:186626408
1394 1394 c, t dbSNP:751625171
1397 1397 c, t dbSNP:368971605
1399 1399 c, t dbSNP:781320720
1401 1401 c, t dbSNP:191120902
1460 1460 c, t dbSNP:534926050
1475 1475 a, g dbSNP:1130163
1477 1477 g, t dbSNP:572376253
1481 1481 c, t dbSNP:149174
1503 1503 c, t dbSNP:558009105
1504 1504 a, g dbSNP:748159813
1550 1550 c, t dbSNP:15860
1551 1551 -, t dbSNP:35568032
1595 1595 a, g dbSNP:772135107
1605 1605 a, g dbSNP:576574973
1613 1613 a, g dbSNP:543560957
1729 1729 g, t dbSNP:562785409
1767 1767 -, a dbSNP:35654352
1767 1767 a, c dbSNP:201288211
1776 1776 -, a dbSNP:397883774
1778 1778 c, t dbSNP:541818620
1783 1783 a, g dbSNP:760209124
1808 1808 a, g, t dbSNP:200856540
1809 1809 -, c dbSNP:35550113
1809 1809 c, t dbSNP:201799049
1810 1810 -, c dbSNP:397792840
1811 1811 -, c dbSNP:397716595
1849 1849 g, t dbSNP:541345989
1917 1917 c, g dbSNP:770712692
1939 1939 c, g dbSNP:146782771
1945 1945 g, t dbSNP:532825835
1947 1947 a, c dbSNP:181014044
1982 1982 a, g dbSNP:153450
2011 2011 a, g dbSNP:530626896
2017 2017 a, g dbSNP:552596465
2018 2018 g, t dbSNP:11262
2099 2099 c, t dbSNP:185065661
2118 2118 c, t dbSNP:534887805
2131 2131 a, g dbSNP:546611992
2202 2202 a, g dbSNP:570980806
2232 2232 a, c dbSNP:115956086
2254 2254 c, t dbSNP:539494761
2309 2309 a, t dbSNP:140540848
2318 2318 a, t dbSNP:191050130
2366 2366 c, t dbSNP:3806952
2378 2378 g, t dbSNP:555509927
2384 2384 a, g dbSNP:532326227
2392 2392 a, g dbSNP:773887985
2401 2401 a, c dbSNP:371212055
2403 2403 c, t dbSNP:3806953
2444 2444 a, g dbSNP:372489813
2487 2487 g, t dbSNP:763507795
2531 2531 a, g dbSNP:12516391
2562 2562 c, g dbSNP:577565833
2607 2607 a, g dbSNP:568732529
2644 2644 c, t dbSNP:544633353
2678 2678 c, t dbSNP:153449
2737 2737 c, t dbSNP:145689253
2738 2738 a, g dbSNP:375679727
2752 2752 a, t dbSNP:561047446
2771 2771 a, c dbSNP:528335575
2790 2790 c, g dbSNP:554614171
2800 2800 a, g dbSNP:755517801
2833 2833 a, g dbSNP:546869021
2838 2838 c, t dbSNP:571403858
2890 2890 g, t dbSNP:532444060
2900 2900 c, t dbSNP:566427956
2967 2967 c, t dbSNP:3734041
2968 2968 a, g dbSNP:569734211
2990 2990 c, t dbSNP:750703170
3012 3012 a, g dbSNP:533895518
3017 3017 a, g dbSNP:756257410
3056 3056 a, g dbSNP:138240164
3061 3061 c, t dbSNP:149180405
3066 3066 a, g dbSNP:747946670
3084 3084 a, g dbSNP:567034017
3121 3121 a, g dbSNP:113128701
3124 3124 c, t dbSNP:567514360
3156 3156 c, t dbSNP:772153529
3174 3174 c, t dbSNP:576999561
3178 3178 c, g dbSNP:777790635
3179 3179 c, t dbSNP:534955137
3180 3180 a, g, t dbSNP:114108271
3226 3226 -, t dbSNP:34492898
3232 3232 a, g dbSNP:770518416
3236 3236 -, t dbSNP:774921338
3236 3236 a, g dbSNP:183242789
3250 3250 -, taa dbSNP:201627590
3251 3251 -, aata dbSNP:143203938
3254 3254 -, aaat dbSNP:35384604
3254 3254 a, g dbSNP:200150752
3304 3304 c, t dbSNP:117832237
3337 3337 c, t dbSNP:575340052
3338 3338 a, g dbSNP:111935946
3350 3350 a, g dbSNP:745598662
3362 3362 a, g dbSNP:561012055
3376 3376 c, t dbSNP:769315888
3386 3386 a, g dbSNP:10076053
3408 3408 c, t dbSNP:540012441
3417 3417 a, g dbSNP:565102108
3428 3428 a, t dbSNP:763236680
3433 3433 c, t dbSNP:143342609
3475 3475 a, g dbSNP:764611573

Target ORF information:

RefSeq Version NM_001167607
Organism Homo sapiens (human)
Definition Homo sapiens GM2 ganglioside activator (GM2A), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001167607

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCAGTCCC TGATGCAGGC TCCCCTCCTG ATCGCCCTGG GCTTGCTTCT CGCGGCCCCT 
GCGCAAGCCC ACCTGAAAAA GCCATCCCAG CTCAGTAGCT TTTCCTGGGA TAACTGTGAT
GAAGGGAAGG ACCCTGCGGT GATCAGAAGC CTGACTCTGG AGCCTGACCC CATCATCGTT
CCTGGAAATG TGACCCTCAG TGTCATGGGC AGCACCAGTG TCCCCCTGAG TTCTCCTCTG
AAGGTGGATT TAGTTTTGGA GAAGGAGGTG GCTGGCCTCT GGATCAAGAT CCCATGCACA
GACTACATTG GCAGCTGTAC CTTTGAACAC TTCTGTGATG TGCTTGACAT GTTAATTCCT
ACTGGGGAGC CCTGCCCAGA GCCCCTGCGT ACCTATGGGC TTCCTTGCCA CTGTCCCTTT
TCCTCTGTTT TGTGTTTGCC AAGGCCAAAC TCCCACTCTC TGCCCCCCTT TAATCCCCTT
TCTACAGTGA GTCCACTACC CTCACTGAAA ATCATTTTGT ACCACTTACA TTTTAGGCTG
GGGCAAGCAG CCCTGACCTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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