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GNAO1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GNAO1
Entrez Gene ID 2775
Full Name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms EIEE17, G-ALPHA-o, GNAO
General protein information
Preferred Names
guanine nucleotide-binding protein G(o) subunit alpha
Names
guanine nucleotide-binding protein G(o) subunit alpha
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q13

Summary The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

139311


mRNA and Protein(s)

mRNA Protein Name
NM_138736 NP_620073 guanine nucleotide-binding protein G(o) subunit alpha isoform b
NM_020988 NP_066268 guanine nucleotide-binding protein G(o) subunit alpha isoform a
XM_011523003 XP_011521305 guanine nucleotide-binding protein G(o) subunit alpha isoform X1



Homo sapiens (human) GNAO1 NP_066268.1
Pan troglodytes (chimpanzee) GNAO1 XP_510976.3
Macaca mulatta (Rhesus monkey) GNAO1 XP_001096035.2
Canis lupus familiaris (dog) GNAO1 XP_005617599.1
Bos taurus (cattle) GNAO1 NP_776750.1
Mus musculus (house mouse) Gnao1 NP_034438.1
Rattus norvegicus (Norway rat) Gnao1 NP_059023.1
Gallus gallus (chicken) GNAO1 NP_001264479.1
Danio rerio (zebrafish) gnao1a NP_957081.1
Drosophila melanogaster (fruit fly) G-oalpha47A NP_724934.1
Caenorhabditis elegans goa-1 NP_492108.1
Xenopus (Silurana) tropicalis (western clawed frog) gnao1 NP_001016995.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GNAO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNAO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu13628
NM_138736 Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu13586
NM_020988 Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu58003 XM_011523003 PREDICTED: Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu13628
Clone ID Related Accession (Same CDS sequence) NM_138736
Accession Version NM_138736.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1065bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-AUG-2015
Organism Homo sapiens (human)
Product guanine nucleotide-binding protein G(o) subunit alpha isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA500625.1, AK056008.1, DA529437.1, BC030027.2, AF493895.1, DA115582.1, BX647214.1 and AL512686.1. On Dec 14, 2007 this sequence version replaced gi:41281684. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) is the same length but has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR936770.1, AF493895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_620073.2
CDS898..1962
Misc Feature(1)787..789(+)
Misc Feature(2)937..1953(+)
Misc Feature(3)997..1941(+)
Misc Feature(4)1015..1875(+)
Misc Feature(5)1015..1038(+)
Misc Feature(6)1018..1545(+)
Misc Feature(7)1426..1452(+)
Misc Feature(8)1441..1443(+)
Misc Feature(9)1444..1548(+)
Misc Feature(10)1450..1548(+)
Misc Feature(11)1498..1509(+)
Misc Feature(12)1501..1551(+)
Misc Feature(13)1705..1716(+)
Misc Feature(14)1846..1896(+)
Misc Feature(15)1870..1878(+)
Exon (1)1..1015
Gene:GNAO1
Gene Synonym:
Exon (2)1016..1058
Gene:GNAO1
Gene Synonym:
Exon (3)1059..1200
Gene:GNAO1
Gene Synonym:
Exon (4)1201..1361
Gene:GNAO1
Gene Synonym:
Exon (5)1362..1490
Gene:GNAO1
Gene Synonym:
Exon (6)1491..1620
Gene:GNAO1
Gene Synonym:
Exon (7)1621..1774
Gene:GNAO1
Gene Synonym:
Exon (8)1775..6211
Gene:GNAO1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_138736
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_138736

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13586
Clone ID Related Accession (Same CDS sequence) NM_020988
Accession Version NM_020988.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1065bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 14-AUG-2015
Organism Homo sapiens (human)
Product guanine nucleotide-binding protein G(o) subunit alpha isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA500625.1, AK056008.1, DA529437.1, BC030027.2 and AC009102.10. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2007 this sequence version replaced gi:10567815. Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030027.2, AK056008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_066268.1
CDS898..1962
Misc Feature(1)787..789(+)
Misc Feature(2)937..1953(+)
Misc Feature(3)997..1941(+)
Misc Feature(4)1015..1875(+)
Misc Feature(5)1015..1038(+)
Misc Feature(6)1018..1545(+)
Misc Feature(7)1336..1338(+)
Misc Feature(8)1426..1452(+)
Misc Feature(9)1432..1434(+)
Misc Feature(10)1441..1443(+)
Misc Feature(11)1444..1548(+)
Misc Feature(12)1450..1548(+)
Misc Feature(13)1498..1509(+)
Misc Feature(14)1501..1551(+)
Misc Feature(15)1705..1716(+)
Misc Feature(16)1846..1896(+)
Misc Feature(17)1870..1878(+)
Misc Feature(18)1948..1950(+)
Exon (1)1..1015
Gene:GNAO1
Gene Synonym:
Exon (2)1016..1058
Gene:GNAO1
Gene Synonym:
Exon (3)1059..1200
Gene:GNAO1
Gene Synonym:
Exon (4)1201..1361
Gene:GNAO1
Gene Synonym:
Exon (5)1362..1490
Gene:GNAO1
Gene Synonym:
Exon (6)1491..1620
Gene:GNAO1
Gene Synonym:
Exon (7)1621..1774
Gene:GNAO1
Gene Synonym:
Exon (8)1775..1990
Gene:GNAO1
Gene Synonym:
Exon (9)1991..3332
Gene:GNAO1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_020988
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020988

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58003
Clone ID Related Accession (Same CDS sequence) XM_011523003
Accession Version XM_011523003.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 939bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product guanine nucleotide-binding protein G(o) subunit alpha isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010498.16) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011521305.1
CDS381..1319
Misc Feature(1)414..1298(+)
Misc Feature(2)414..1283(+)
Misc Feature(3)465..902(+)
Misc Feature(4)783..809(+)
Misc Feature(5)798..1232(+)
Misc Feature(6)798..800(+)
Misc Feature(7)801..905(+)
Misc Feature(8)807..905(+)
Misc Feature(9)855..866(+)
Misc Feature(10)858..908(+)
Misc Feature(11)1062..1073(+)
Misc Feature(12)1203..1253(+)
Misc Feature(13)1227..1235(+)
Translation

Target ORF information:

RefSeq Version XM_011523003
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011523003

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Progressive Movement Disorder in Brothers Carrying a GNAO1 Mutation Responsive to Deep Brain Stimulation
J. Child Neurol. (2015) In press
Kulkarni N, Tang S, Bhardwaj R, Bernes S and Grebe TA.


book

Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay
Eur. J. Hum. Genet. (2015) In press
Saitsu H, Fukai R, Ben-Zeev B, Sakai Y, Mimaki M, Okamoto N, Suzuki Y, Monden Y, Saito H, Tziperman B, Torio M, Akamine S, Takahashi N, Osaka H, Yamagata T, Nakamura K, Tsurusaki Y, Nakashima M, Miyake N, Shiina M, Ogata K and Matsumoto N.


book

Identification of Key Genes and Pathways in Renal Cell Carcinoma Through Expression Profiling Data
Kidney Blood Press. Res. 40 (3), 288-297 (2015)
Liu X, Wang J and Sun G.


book

Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach
Radiol Oncol 48 (3), 257-266 (2014)
Zupancic K, Blejec A, Herman A, Veber M, Verbovsek U, Korsic M, Knezevic M, Rozman P, Turnsek TL, Gruden K and Motaln H.


book

Harnessing gene expression networks to prioritize candidate epileptic encephalopathy genes
PLoS ONE 9 (7), E102079 (2014)
Oliver KL, Lukic V, Thorne NP, Berkovic SF, Scheffer IE and Bahlo M.


book

Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
Cell 70 (3), 411-418 (1992)
Berstein G, Blank JL, Jhon DY, Exton JH, Rhee SG and Ross EM.


book

Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go
J. Biol. Chem. 267 (14), 9852-9857 (1992)
Coupry I, Duzic E and Lanier SM.


book

Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions
J. Biol. Chem. 267 (9), 6272-6277 (1992)
Denker BM, Neer EJ and Schmidt CJ.


book

Structural and functional studies of cross-linked Go protein subunits
J. Biol. Chem. 266 (6), 3900-3906 (1991)
Yi F, Denker BM and Neer EJ.


book

Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16
Mol. Cell. Biol. 11 (2), 1146-1155 (1991)
Murtagh JJ Jr, Eddy R, Shows TB, Moss J and Vaughan M.


 
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