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B4GALNT3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol B4GALNT3
Entrez Gene ID 283358
Full Name beta-1,4-N-acetyl-galactosaminyl transferase 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.33

Summary B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]. lac of sum
Disorder MIM:

612220


mRNA and Protein(s)

mRNA Protein Name
NM_173593 NP_775864 beta-1,4-N-acetylgalactosaminyltransferase 3


Homo sapiens (human) B4GALNT3 NP_775864.3
Pan troglodytes (chimpanzee) B4GALNT3 XP_508918.2
Macaca mulatta (Rhesus monkey) B4GALNT3 XP_001094974.1
Canis lupus familiaris (dog) B4GALNT3 XP_543878.2
Bos taurus (cattle) B4GALNT3 NP_001193624.1
Mus musculus (house mouse) B4galnt3 NP_942585.1
Rattus norvegicus (Norway rat) B4galnt3 NP_001178905.1
Gallus gallus (chicken) B4GALNT3 XP_416381.4
Danio rerio (zebrafish) b4galnt3b XP_001342883.4
Xenopus (Silurana) tropicalis (western clawed frog) b4galnt3 XP_004912790.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following B4GALNT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B4GALNT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu07318 NM_173593 Homo sapiens beta-1,4-N-acetyl-galactosaminyl transferase 3 (B4GALNT3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $657.30
$939.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu07318
Clone ID Related Accession (Same CDS sequence) NM_173593
Accession Version NM_173593.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2997bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product beta-1,4-N-acetylgalactosaminyltransferase 3
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB089940.1, CN400443.1, AK093503.1 and AK131277.1. On Jul 20, 2005 this sequence version replaced gi:38566691. ##Evidence-Data-START## Transcript exon combination :: AB089940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_775864.3
CDS1..2997
Misc Feature(1)73..135(+)
Misc Feature(2)418..831(+)
Misc Feature(3)2377..2655(+)
Misc Feature(4)2725..2955(+)
Exon (1)1..169
Gene:B4GALNT3
Gene Synonym:
Exon (2)170..273
Gene:B4GALNT3
Gene Synonym:
Exon (3)274..351
Gene:B4GALNT3
Gene Synonym:
Exon (4)352..447
Gene:B4GALNT3
Gene Synonym:
Exon (5)448..538
Gene:B4GALNT3
Gene Synonym:
Exon (6)539..639
Gene:B4GALNT3
Gene Synonym:
Exon (7)640..707
Gene:B4GALNT3
Gene Synonym:
Exon (8)708..786
Gene:B4GALNT3
Gene Synonym:
Exon (9)787..853
Gene:B4GALNT3
Gene Synonym:
Exon (10)854..997
Gene:B4GALNT3
Gene Synonym:
Exon (11)998..1107
Gene:B4GALNT3
Gene Synonym:
Exon (12)1108..1208
Gene:B4GALNT3
Gene Synonym:
Exon (13)1209..1270
Gene:B4GALNT3
Gene Synonym:
Exon (14)1271..2060
Gene:B4GALNT3
Gene Synonym:
Exon (15)2061..2380
Gene:B4GALNT3
Gene Synonym:
Exon (16)2381..2534
Gene:B4GALNT3
Gene Synonym:
Exon (17)2535..2607
Gene:B4GALNT3
Gene Synonym:
Exon (18)2608..2761
Gene:B4GALNT3
Gene Synonym:
Exon (19)2762..2888
Gene:B4GALNT3
Gene Synonym:
Exon (20)2889..3438
Gene:B4GALNT3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_173593
Organism Homo sapiens (human)
Definition Homo sapiens beta-1,4-N-acetyl-galactosaminyl transferase 3 (B4GALNT3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_173593

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4
J. Biol. Chem. 287 (34), 29204-29212 (2012)
Fiete D, Beranek M and Baenziger JU.


book

Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4
J. Biol. Chem. 287 (34), 29194-29203 (2012)
Fiete D, Beranek M and Baenziger JU.


book

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest
PLoS ONE 5 (3), E9879 (2010)
Arking DE, Reinier K, Post W, Jui J, Hilton G, O'Connor A, Prineas RJ, Boerwinkle E, Psaty BM, Tomaselli GF, Rea T, Sotoodehnia N, Siscovick DS, Burke GL, Marban E, Spooner PM, Chakravarti A and Chugh SS.


book

A necessary and sufficient determinant for protein-selective glycosylation in vivo
J. Biol. Chem. 283 (4), 1985-1991 (2008)
Miller E, Fiete D, Blake NM, Beranek M, Oates EL, Mi Y, Roseman DS and Baenziger JU.


book

Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells
Mol. Cancer Res. 5 (6), 543-552 (2007)
Huang J, Liang JT, Huang HC, Shen TL, Chen HY, Lin NY, Che MI, Lin WC and Huang MC.


book

Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa
Glycobiology 16 (9), 777-785 (2006)
Ikehara Y, Sato T, Niwa T, Nakamura S, Gotoh M, Ikehara SK, Kiyohara K, Aoki C, Iwai T, Nakanishi H, Hirabayashi J, Tatematsu M and Narimatsu H.


book

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc
J. Biol. Chem. 278 (48), 47534-47544 (2003)
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H and Narimatsu H.


 
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