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KRT6C cDNA ORF clone, Homo sapiens (human)

Gene Symbol KRT6C
Entrez Gene ID 286887
Full Name keratin 6C, type II
Synonyms K6E, KRT6E, PPKNEFD
General protein information
Preferred Names
keratin, type II cytoskeletal 6C
Names
keratin, type II cytoskeletal 6C
K6C
CK-6C
CK-6E
keratin 6E
keratin-6C
keratin K6h
cytokeratin-6C
cytokeratin-6E
type-II keratin Kb12
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13.13

Summary Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]. lac of sum
Disorder MIM:

612315


mRNA and Protein(s)

mRNA Protein Name
NM_173086 NP_775109 keratin, type II cytoskeletal 6C


Homo sapiens (human) KRT6C NP_775109.2
Pan troglodytes (chimpanzee) KRT6B XP_001143262.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRT6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18637 NM_173086 Homo sapiens keratin 6C, type II (KRT6C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18637
Clone ID Related Accession (Same CDS sequence) NM_173086
Accession Version NM_173086.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1695bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product keratin, type II cytoskeletal 6C
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC110639.1 and AC055736.20. This sequence is a reference standard in the RefSeqGene project. On Aug 15, 2007 this sequence version replaced gi:141802000. ##Evidence-Data-START## Transcript exon combination :: BC110639.1, L42611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC
CTCAGGAGGC AGCTGGACAG CATCGTCGGG GAACGGGGCC GCCTGGACTC GGAGCTGAGA
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGATG AGATCAACTT CCTGAGAGCC
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA
TACGAGGAGA TTGCTCAGAG GAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA TGTCAAGAAG
CAGTGTGCCA GCCTGCAGGC TGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCACTC
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGATGTG
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC
GTTGGACAAG TCAACGTCTC TGTAGTACAG TCCACCATCT CCAGTGGCTA TGGCGGTGCC
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT
CTTGGCATTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG
AGCTACAAGC ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_775109.2
CDS49..1743
Misc Feature(1)52..534(+)
Misc Feature(2)52..54(+)
Misc Feature(3)226..228(+)
Misc Feature(4)532..1473(+)
Misc Feature(5)535..1464(+)
Misc Feature(6)535..642(+)
Misc Feature(7)643..699(+)
Misc Feature(8)700..975(+)
Misc Feature(9)976..1047(+)
Misc Feature(10)1048..1464(+)
Misc Feature(11)1156..>1491(+)
Misc Feature(12)1288..1290(+)
Misc Feature(13)1465..1740(+)
Exon (1)1..588
Gene:KRT6C
Gene Synonym:
Exon (2)589..803
Gene:KRT6C
Gene Synonym:
Exon (3)804..864
Gene:KRT6C
Gene Synonym:
Exon (4)865..960
Gene:KRT6C
Gene Synonym:
Exon (5)961..1125
Gene:KRT6C
Gene Synonym:
Exon (6)1126..1251
Gene:KRT6C
Gene Synonym:
Exon (7)1252..1472
Gene:KRT6C
Gene Synonym:
Exon (8)1473..1507
Gene:KRT6C
Gene Synonym:
Exon (9)1508..2289
Gene:KRT6C
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_173086
Organism Homo sapiens (human)
Definition Homo sapiens keratin 6C, type II (KRT6C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_173086

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC
CTCAGGAGGC AGCTGGACAG CATCGTCGGG GAACGGGGCC GCCTGGACTC GGAGCTGAGA
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGATG AGATCAACTT CCTGAGAGCC
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA
TACGAGGAGA TTGCTCAGAG GAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA TGTCAAGAAG
CAGTGTGCCA GCCTGCAGGC TGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCACTC
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGATGTG
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC
GTTGGACAAG TCAACGTCTC TGTAGTACAG TCCACCATCT CCAGTGGCTA TGGCGGTGCC
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT
CTTGGCATTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG
AGCTACAAGC ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma
J. Dermatol. 40 (7), 553-557 (2013)
Kubo A, Oura Y, Hirano T, Aoyama Y, Sato S, Nakamura K, Takae Y and Amagai M.


book

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
Proteomics 13 (10-11), 1667-1671 (2013)
Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T and Drake RR.


book

Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma
J. Invest. Dermatol. 130 (2), 336-338 (2010)
Bowden PE.


book

Keratin K6c mutations cause focal palmoplantar keratoderma
J. Invest. Dermatol. 130 (2), 425-429 (2010)
Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WH and Smith FJ.


book

New consensus nomenclature for mammalian keratins
J. Cell Biol. 174 (2), 169-174 (2006)
Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA and Wright MW.


book

The finished DNA sequence of human chromosome 12
Nature 440 (7082), 346-351 (2006)
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G and Gibbs RA.


book

Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18
J. Cell. Sci. 114 (PT 14), 2569-2575 (2001)
Hesse M, Magin TM and Weber K.


book

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431
J. Biol. Chem. 272 (11), 7556-7564 (1997)
Ku NO and Omary MB.


book

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms
J. Biol. Chem. 270 (31), 18581-18592 (1995)
Takahashi K, Paladini RD and Coulombe PA.


 
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