||ORF Nucleotide Sequence (Length: 984bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||G protein pathway suppressor 2
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC013652.1 and BC014192.2.
On or before Oct 6, 2004 this sequence version replaced
Summary: This gene encodes a protein involved in G
protein-mitogen-activated protein kinase (MAPK) signaling cascades.
When overexpressed in mammalian cells, this gene could potently
suppress a RAS- and MAPK-mediated signal and interfere with JNK
activity, suggesting that the function of this gene may be signal
repression. The encoded protein is an integral subunit of the
NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3)
complex, and it was shown that the complex inhibits JNK activation
through this subunit and thus could potentially provide an
alternative mechanism for hormone-mediated antagonism of AP1
(activator protein 1) function. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.