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GPS2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GPS2
Entrez Gene ID 2874
Full Name G protein pathway suppressor 2
Synonyms AMF-1
General protein information
Preferred Names
G protein pathway suppressor 2
Names
G protein pathway suppressor 2
GPS-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601935


mRNA and Protein(s)

mRNA Protein Name
NM_004489 NP_004480 G protein pathway suppressor 2



Homo sapiens (human) GPS2 NP_004480.1
Pan troglodytes (chimpanzee) GPS2 XP_511971.3
Macaca mulatta (Rhesus monkey) LOC721816 XP_002800321.1
Canis lupus familiaris (dog) GPS2 XP_003639092.1
Bos taurus (cattle) GPS2 NP_001069242.1
Mus musculus (house mouse) Gps2 NP_062700.2
Rattus norvegicus (Norway rat) Gps2 NP_001017477.1
Danio rerio (zebrafish) gps2 NP_957267.1
Xenopus (Silurana) tropicalis (western clawed frog) gps2 NP_001107718.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu04401
NM_004489 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu04401
Clone ID Related Accession (Same CDS sequence) NM_004489
Accession Version NM_004489.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 984bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product G protein pathway suppressor 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013652.1 and BC014192.2. On or before Oct 6, 2004 this sequence version replaced gi:14270480, gi:14270479. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004480.1
CDS77..1060
Misc Feature(1)200..436(+)
Exon (1)1..9
Gene:GPS2
Gene Synonym:
Exon (2)10..170
Gene:GPS2
Gene Synonym:
Exon (3)171..280
Gene:GPS2
Gene Synonym:
Exon (4)281..393
Gene:GPS2
Gene Synonym:
Exon (5)394..473
Gene:GPS2
Gene Synonym:
Exon (6)474..556
Gene:GPS2
Gene Synonym:
Exon (7)557..710
Gene:GPS2
Gene Synonym:
Exon (8)711..800
Gene:GPS2
Gene Synonym:
Exon (9)801..880
Gene:GPS2
Gene Synonym:
Exon (10)881..976
Gene:GPS2
Gene Synonym:
Exon (11)977..1157
Gene:GPS2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004489
Organism Homo sapiens (human)
Definition Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004489

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
J. Clin. Invest. 123 (1), 362-379 (2013)
Toubal A, Clement K, Fan R, Ancel P, Pelloux V, Rouault C, Veyrie N, Hartemann A, Treuter E and Venteclef N.


book

Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma
FASEB J. 24 (3), 937-946 (2010)
Jarmalavicius S, Trefzer U and Walden P.


book

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
Genes Dev. 24 (4), 381-395 (2010)
Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Janne OA, Gustafsson JA, Steffensen KR and Treuter E.


book

G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation
J. Biol. Chem. 284 (52), 36395-36404 (2009)
Cheng X and Kao HY.


book

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
Mol. Cell 34 (4), 510-518 (2009)
Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA and Treuter E.


book

AMF1 (GPS2) modulates p53 transactivation
Mol. Cell. Biol. 21 (17), 5913-5924 (2001)
Peng YC, Kuo F, Breiding DE, Wang YF, Mansur CP and Androphy EJ.


book

Gps2, a protein partner for human papillomavirus E6 proteins
J. Virol. 75 (1), 151-160 (2001)
Degenhardt YY and Silverstein SJ.


book

AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins
J. Virol. 74 (13), 5872-5879 (2000)
Peng YC, Breiding DE, Sverdrup F, Richard J and Androphy EJ.


book

A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha
J. Biol. Chem. 272 (41), 25816-25823 (1997)
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS and Jeang KT.


book

Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells
Mol. Cell. Biol. 16 (12), 6698-6706 (1996)
Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W and Colicelli J.


 
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