The following GPS2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPS2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 984bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||G protein pathway suppressor 2
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC013652.1 and BC014192.2.
On or before Oct 6, 2004 this sequence version replaced
Summary: This gene encodes a protein involved in G
protein-mitogen-activated protein kinase (MAPK) signaling cascades.
When overexpressed in mammalian cells, this gene could potently
suppress a RAS- and MAPK-mediated signal and interfere with JNK
activity, suggesting that the function of this gene may be signal
repression. The encoded protein is an integral subunit of the
NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3)
complex, and it was shown that the complex inhibits JNK activation
through this subunit and thus could potentially provide an
alternative mechanism for hormone-mediated antagonism of AP1
(activator protein 1) function. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.