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GPS2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GPS2
Entrez Gene ID 2874
Full Name G protein pathway suppressor 2
Synonyms AMF-1
General protein information
Preferred Names
G protein pathway suppressor 2
Names
G protein pathway suppressor 2
GPS-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601935

Disorder Html:





The following GPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu04401 NM_004489 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$139.30
$199.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu04401
Accession Version NM_004489.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 984bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product G protein pathway suppressor 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013652.1 and BC014192.2. On or before Oct 6, 2004 this sequence version replaced gi:14270480, gi:14270479. Summary: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_004480.1
CDS77..1060
Misc Feature(1)200..436(+)
Exon (1)1..9
Gene:GPS2
Gene Synonym:
Exon (2)10..170
Gene:GPS2
Gene Synonym:
Exon (3)171..280
Gene:GPS2
Gene Synonym:
Exon (4)281..393
Gene:GPS2
Gene Synonym:
Exon (5)394..473
Gene:GPS2
Gene Synonym:
Exon (6)474..556
Gene:GPS2
Gene Synonym:
Exon (7)557..710
Gene:GPS2
Gene Synonym:
Exon (8)711..800
Gene:GPS2
Gene Synonym:
Exon (9)801..880
Gene:GPS2
Gene Synonym:
Exon (10)881..976
Gene:GPS2
Gene Synonym:
Exon (11)977..1157
Gene:GPS2
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:776239898
11 11 c, t dbSNP:780293484
20 20 a, t dbSNP:758549735
26 26 a, g dbSNP:753869459
29 29 a, c dbSNP:200170373
34 34 g, t dbSNP:764101033
36 36 -, ga dbSNP:757671243
36 36 a, c, g dbSNP:752469217
48 48 c, t dbSNP:767280768
58 58 a, g dbSNP:759127635
61 61 c, g dbSNP:773982297
65 65 c, t dbSNP:568610925
68 68 c, g dbSNP:762414201
71 71 a, g dbSNP:773753352
73 73 a, c dbSNP:113746748
75 75 c, g dbSNP:140627974
82 82 c, t dbSNP:748648209
94 94 a, g dbSNP:147873069
97 97 c, t dbSNP:142288970
111 111 a, g dbSNP:563273312
115 115 c, t dbSNP:549389257
121 121 c, g dbSNP:374276970
124 124 a, g dbSNP:750554612
127 127 a, g dbSNP:532828296
134 134 a, c dbSNP:756013916
148 148 c, g dbSNP:752624973
154 154 a, g dbSNP:767277141
181 181 a, g dbSNP:750108379
185 185 -, t dbSNP:751173137
185 185 g, t dbSNP:764921529
190 190 a, g dbSNP:756811014
205 205 a, g dbSNP:755684619
208 208 g, t dbSNP:763632313
210 210 a, g dbSNP:574096182
211 211 a, g dbSNP:148743274
228 228 a, g dbSNP:776129489
251 251 a, c dbSNP:768065711
259 259 a, g dbSNP:759918169
260 260 c, t dbSNP:200211892
262 262 a, g dbSNP:771202809
268 268 a, c, g dbSNP:77956194
275 275 a, g dbSNP:113167184
277 277 a, g dbSNP:773345677
285 285 a, t dbSNP:778784405
286 286 c, g dbSNP:534281043
296 296 -, gag dbSNP:757139280
299 299 -, aag dbSNP:757956318
301 301 a, g dbSNP:749038830
302 302 c, t dbSNP:777541205
310 310 g, t dbSNP:149591136
313 313 a, t dbSNP:139664491
316 316 a, g dbSNP:780806259
328 328 c, t dbSNP:369696077
338 338 -, c dbSNP:749873385
338 338 c, g, t dbSNP:11541828
340 340 a, g dbSNP:751951805
379 379 a, g dbSNP:766822954
391 391 c, g dbSNP:773127395
397 397 a, c, t dbSNP:750817188
399 399 c, t dbSNP:371318711
409 409 a, c, g, t dbSNP:2292064
409 409 -, a, g dbSNP:386352658
413 413 a, t dbSNP:764303771
417 417 c, g, t dbSNP:774399124
420 420 c, t dbSNP:202127770
430 430 a, g dbSNP:762940203
434 434 c, g, t dbSNP:769651838
446 446 a, g dbSNP:747205747
447 447 c, g, t dbSNP:768252271
460 460 c, t dbSNP:746478678
461 461 -, ctc dbSNP:776495886
463 463 c, t dbSNP:779577464
471 471 -, a dbSNP:763910815
472 472 c, g dbSNP:758834183
473 473 g, t dbSNP:746318470
475 475 -, g dbSNP:761006542
481 481 c, t dbSNP:778163298
487 487 a, g dbSNP:746446577
488 488 c, t dbSNP:752902884
490 490 c, t dbSNP:142228539
492 492 a, g dbSNP:755102164
495 495 g, t dbSNP:11541856
500 500 a, g dbSNP:750424002
504 504 c, t dbSNP:765243488
509 509 a, g dbSNP:779552413
518 518 a, g dbSNP:761793531
533 533 a, g dbSNP:753579625
542 542 a, c dbSNP:763892022
545 545 -, c dbSNP:775804583
547 547 a, g dbSNP:531403680
551 551 c, t dbSNP:200523158
555 555 c, t dbSNP:760303804
559 559 c, t dbSNP:752523293
560 560 a, c dbSNP:767237004
561 561 a, g dbSNP:754634220
565 565 c, t dbSNP:751195748
568 568 c, t dbSNP:184661596
569 569 a, g dbSNP:762497187
573 573 a, g dbSNP:773643640
574 574 a, c dbSNP:374699021
585 585 c, t dbSNP:371474455
595 595 a, g dbSNP:762187704
600 600 a, c dbSNP:777140504
606 606 a, g dbSNP:769128301
622 622 c, t dbSNP:201950027
633 633 g, t dbSNP:775822680
634 634 g, t dbSNP:772091319
639 639 a, g dbSNP:745980232
654 654 a, c dbSNP:778814855
655 655 a, c, g dbSNP:748017048
661 661 a, t dbSNP:781026840
669 669 a, g dbSNP:754766975
673 673 c, g, t dbSNP:766035428
674 674 a, g dbSNP:200001346
680 680 c, g, t dbSNP:376328573
683 683 a, g dbSNP:762468194
692 692 c, t dbSNP:754391867
693 693 c, t dbSNP:764591627
694 694 c, t dbSNP:761096798
695 695 a, t dbSNP:775945486
706 706 c, t dbSNP:772367743
713 713 c, t dbSNP:748835899
715 715 g, t dbSNP:371218282
716 716 g, t dbSNP:756698225
718 718 a, g dbSNP:753127153
719 719 a, g dbSNP:369293222
721 721 a, g dbSNP:755269537
724 724 c, t dbSNP:751860704
725 725 c, t dbSNP:766613352
730 730 a, g dbSNP:763123403
732 732 c, t dbSNP:773286418
736 736 a, g dbSNP:8076120
738 738 a, t dbSNP:760722898
740 740 c, t dbSNP:775259683
742 742 a, g dbSNP:771950826
746 746 c, t dbSNP:745671551
757 757 -, acagcc dbSNP:779726141
762 762 -, accgcc dbSNP:748493582
765 765 a, g dbSNP:774154272
766 766 c, t dbSNP:11541830
771 771 c, t dbSNP:870892
772 772 a, g dbSNP:141649936
774 774 a, g dbSNP:748888937
778 778 c, t dbSNP:777479936
788 788 c, g dbSNP:375006052
792 792 -, ctca dbSNP:758044036
795 795 a, c dbSNP:748734044
808 808 c, g dbSNP:769049828
812 812 c, t dbSNP:747493645
817 817 c, t dbSNP:112435041
819 819 a, g dbSNP:780454570
823 823 c, t dbSNP:758758785
824 824 c, g dbSNP:368029563
825 825 a, t dbSNP:750692300
832 832 a, g dbSNP:147983205
840 840 a, c dbSNP:757458525
842 842 a, g dbSNP:753866859
847 847 a, g dbSNP:144209448
850 850 c, t dbSNP:759447194
859 859 a, g dbSNP:751534351
871 871 c, t dbSNP:2270981
874 874 c, t dbSNP:762822597
877 877 c, t dbSNP:773097026
880 880 a, g dbSNP:769364819
885 885 c, g dbSNP:772570395
888 888 a, t dbSNP:771583507
890 890 c, t dbSNP:192050225
891 891 a, g dbSNP:774633910
901 901 c, t dbSNP:771319368
904 904 c, g dbSNP:749508687
918 918 a, c dbSNP:778030372
922 922 c, t dbSNP:566343946
923 923 c, t dbSNP:756358952
924 924 c, g dbSNP:748273783
927 927 a, g dbSNP:781356479
931 931 c, g dbSNP:758427184
932 932 -, ctt dbSNP:76713000
936 936 c, t dbSNP:750374798
942 942 a, c dbSNP:765011305
943 943 c, g dbSNP:139574677
949 949 c, g dbSNP:201162324
951 951 c, t dbSNP:763838649
954 954 g, t dbSNP:760253219
958 958 a, g dbSNP:774992864
960 960 g, t dbSNP:766997759
961 961 a, g dbSNP:147815838
965 965 c, t dbSNP:774886900
967 967 a, g dbSNP:146023090
968 968 c, g dbSNP:749689174
969 969 c, g dbSNP:773412928
978 978 c, t dbSNP:780901898
979 979 a, c, g dbSNP:530877542
984 984 g, t dbSNP:751162059
992 992 a, g dbSNP:2292065
996 996 a, g dbSNP:757816191
1004 1004 c, g dbSNP:751015934
1007 1007 a, c dbSNP:765869813
1008 1008 c, t dbSNP:762371964
1011 1011 a, g dbSNP:754267121
1012 1012 a, g dbSNP:764351211
1015 1015 c, t dbSNP:761024211
1018 1018 c, t dbSNP:775542447
1020 1020 c, t dbSNP:200535238
1030 1030 -, ca dbSNP:773759090
1033 1033 c, t dbSNP:767681373
1040 1040 c, t dbSNP:759555319
1041 1041 c, t dbSNP:774371895
1042 1042 a, g dbSNP:142252898
1045 1045 a, g dbSNP:147653865
1048 1048 c, t dbSNP:3180570
1049 1049 c, t dbSNP:201341909
1050 1050 a, t dbSNP:776473038
1052 1052 -, cac dbSNP:770259226
1054 1054 c, t dbSNP:376284181
1057 1057 a, c, g dbSNP:779551423
1061 1061 c, t dbSNP:113440274
1062 1062 c, t dbSNP:758022867
1067 1067 g, t dbSNP:199805281
1070 1070 a, t dbSNP:745403587
1071 1071 a, g, t dbSNP:370769252
1076 1076 g, t dbSNP:754392019
1080 1080 a, g dbSNP:202227992
1081 1081 c, t dbSNP:370539781
1082 1082 a, g dbSNP:756408852
1083 1083 c, t dbSNP:753053885
1085 1085 a, c dbSNP:767661678
1087 1087 a, t dbSNP:759684956
1088 1088 c, t dbSNP:774431238
1089 1089 c, g dbSNP:766436965
1090 1090 c, g dbSNP:761810474
1093 1093 -, c dbSNP:748581349
1093 1093 c, g, t dbSNP:374342877
1099 1099 a, g dbSNP:746803379
1101 1101 c, t dbSNP:376182174
1102 1102 a, g dbSNP:373554798
1103 1103 c, g, t dbSNP:778631531
1107 1107 g, t dbSNP:542930712
1109 1109 a, g dbSNP:749859598
1110 1110 c, g dbSNP:778162432
1111 1111 a, g dbSNP:756600341
1121 1121 g, t dbSNP:574300589
1145 1145 a, c dbSNP:554236502

Target ORF information:

RefSeq Version NM_004489
Organism Homo sapiens (human)
Definition Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004489

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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