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GPX3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GPX3
Entrez Gene ID 2878
Full Name glutathione peroxidase 3
Synonyms GPx-P, GSHPx-3, GSHPx-P
General protein information
Preferred Names
glutathione peroxidase 3
Names
glutathione peroxidase 3
GPx-3
plasma glutathione peroxidase
extracellular glutathione peroxidase
NP_002075.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33.1

Summary This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

138321


mRNA and Protein(s)

mRNA Protein Name
NM_002084 NP_002075 glutathione peroxidase 3 precursor



Homo sapiens (human) GPX3 NP_002075.2
Pan troglodytes (chimpanzee) GPX3 NP_001108629.1
Macaca mulatta (Rhesus monkey) GPX3 NP_001152772.1
Canis lupus familiaris (dog) GPX3 NP_001157926.1
Bos taurus (cattle) GPX3 NP_776502.1
Mus musculus (house mouse) Gpx3 NP_032187.2
Rattus norvegicus (Norway rat) Gpx3 NP_071970.2
Gallus gallus (chicken) GPX3 NP_001156704.1
Danio rerio (zebrafish) gpx3 NP_001131027.1
Xenopus (Silurana) tropicalis (western clawed frog) gpx3 NP_988961.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu14624
NM_002084 Homo sapiens glutathione peroxidase 3 (GPX3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu14624
Clone ID Related Accession (Same CDS sequence) NM_002084
Accession Version NM_002084.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product glutathione peroxidase 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI522602.1, AC008641.7 and AL036834.2. On Mar 16, 2006 this sequence version replaced gi:6006000. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC050378.1, BC025956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCCGGC TGCTGCAGGC GTCCTGCCTG CTTTCCCTGC TCCTGGCCGG CTTCGTCTCG 
CAGAGCCGGG GACAAGAGAA GTCGAAGATG GACTGCCATG GTGGCATAAG TGGCACCATT
TACGAGTACG GAGCCCTCAC CATTGATGGG GAGGAGTACA TCCCCTTCAA GCAGTATGCT
GGCAAATACG TCCTCTTTGT CAACGTGGCC AGCTACTGAG GCCTGACGGG CCAGTACATT
GAACTGAATG CACTACAGGA AGAGCTTGCA CCATTCGGTC TGGTCATTCT GGGCTTTCCC
TGCAACCAAT TTGGAAAACA GGAACCAGGA GAGAACTCAG AGATCCTTCC TACCCTCAAG
TATGTCCGAC CAGGTGGAGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTC
AATGGAGAGA AAGAGCAGAA ATTCTACACT TTCCTAAAGA ACTCCTGTCC TCCCACCTCG
GAGCTCCTGG GTACATCTGA CCGCCTCTTC TGGGAACCCA TGAAGGTTCA CGACATCCGC
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGTATAC CCATCATGCG CTGGCACCAC
CGGACCACGG TCAGCAACGT CAAGATGGAC ATCCTGTCCT ACATGAGGCG GCAGGCAGCC
CTGGGGGTCA AGAGGAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002075.2
CDS218..898
Misc Feature(1)197..199(+)
Misc Feature(2)332..850(+)
Misc Feature(3)434..760(+)
Misc Feature(4)434..436(+)
Misc Feature(5)434..436(+)
Misc Feature(6)533..580(+)
Exon (1)1..304
Gene:GPX3
Gene Synonym:
Exon (2)305..458
Gene:GPX3
Gene Synonym:
Exon (3)459..576
Gene:GPX3
Gene Synonym:
Exon (4)577..676
Gene:GPX3
Gene Synonym:
Exon (5)677..1761
Gene:GPX3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002084
Organism Homo sapiens (human)
Definition Homo sapiens glutathione peroxidase 3 (GPX3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002084

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCCGGC TGCTGCAGGC GTCCTGCCTG CTTTCCCTGC TCCTGGCCGG CTTCGTCTCG 
CAGAGCCGGG GACAAGAGAA GTCGAAGATG GACTGCCATG GTGGCATAAG TGGCACCATT
TACGAGTACG GAGCCCTCAC CATTGATGGG GAGGAGTACA TCCCCTTCAA GCAGTATGCT
GGCAAATACG TCCTCTTTGT CAACGTGGCC AGCTACTGAG GCCTGACGGG CCAGTACATT
GAACTGAATG CACTACAGGA AGAGCTTGCA CCATTCGGTC TGGTCATTCT GGGCTTTCCC
TGCAACCAAT TTGGAAAACA GGAACCAGGA GAGAACTCAG AGATCCTTCC TACCCTCAAG
TATGTCCGAC CAGGTGGAGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTC
AATGGAGAGA AAGAGCAGAA ATTCTACACT TTCCTAAAGA ACTCCTGTCC TCCCACCTCG
GAGCTCCTGG GTACATCTGA CCGCCTCTTC TGGGAACCCA TGAAGGTTCA CGACATCCGC
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGTATAC CCATCATGCG CTGGCACCAC
CGGACCACGG TCAGCAACGT CAAGATGGAC ATCCTGTCCT ACATGAGGCG GCAGGCAGCC
CTGGGGGTCA AGAGGAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

APOA1 mRNA expression in ovarian serous carcinoma effusions is a marker of longer survival
Am. J. Clin. Pathol. 142 (1), 51-57 (2014)
Tuft Stavnes H, Nymoen DA, Hetland Falkenthal TE, Kaern J, Trope CG and Davidson B.


book

Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome
Arch. Med. Res. 45 (5), 375-382 (2014)
Baez-Duarte BG, Mendoza-Carrera F, Garcia-Zapien A, Flores-Martinez SE, Sanchez-Corona J, Zamora-Ginez I, Torres-Rasgado E, Leon-Chavez BA and Perez-Fuentes R.


book

Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer
Oncol. Rep. 31 (6), 2587-2592 (2014)
Zhang X, Zheng Z, Yingji S, Kim H, Jin R, Renshu L, Lee DY, Roh MR and Yang S.


book

Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window
. Biomed. J. 18 (2), 60-66 (2014)
Farimani Sanoee M, Alizamir T, Faramarzi S, Saidijam M, Yadegarazari R, Shabab N, Rastgoo Haghi A and Alizadeh Z.


book

RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients
Reprod. Biol. Endocrinol. 11, 109 (2013)
Huang X, Hao C, Shen X, Zhang Y and Liu X.


book

Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents
Blood 79 (12), 3233-3238 (1992)
Chu FF, Esworthy RS, Doroshow JH, Doan K and Liu XF.


book

Characterization and partial amino acid sequence of human plasma glutathione peroxidase
Arch. Biochem. Biophys. 286 (2), 330-336 (1991)
Esworthy RS, Chu FF, Paxton RJ, Akman S and Doroshow JH.


book

Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences
J. Biochem. 108 (2), 145-148 (1990)
Takahashi K, Akasaka M, Yamamoto Y, Kobayashi C, Mizoguchi J and Koyama J.


book

Antihuman plasma glutathione peroxidase antibodies: immunologic investigations to determine plasma glutathione peroxidase protein and selenium content in plasma
Blood 73 (1), 318-323 (1989)
Avissar N, Whitin JC, Allen PZ, Palmer IS and Cohen HJ.


book

Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme
Arch. Biochem. Biophys. 256 (2), 677-686 (1987)
Takahashi,K., Avissar,N., Whitin,J. and Cohen,H.


 
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