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SLC25A4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SLC25A4
Entrez Gene ID 291
Full Name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Synonyms AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1
General protein information
Preferred Names
ADP/ATP translocase 1
Names
ADP/ATP translocase 1
ANT 1
ADP,ATP carrier protein 1
solute carrier family 25 member 4
heart/skeletal muscle ATP/ADP translocator
ADP,ATP carrier protein, heart/skeletal muscle
adenine nucleotide translocator 1 (skeletal muscle)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q35

Summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]. lac of sum
Disorder MIM:

103220

Disorder Html: Progressive external ophthalmoplegia with mitochondrial DNA

mRNA and Protein(s)

mRNA Protein Name
NM_001151 NP_001142 ADP/ATP translocase 1

KEGG
hsa04020 Calcium signaling pathway
hsa05016 Huntington's disease
hsa05012 Parkinson's disease
hsa05166 HTLV-I infection
hsa04022 cGMP-PKG signaling pathway
Reactome
R-HSA-1643685 Disease
R-HSA-162906 HIV Infection
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-162909 Host Interactions of HIV factors
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-5663205 Infectious disease
R-HSA-392499 Metabolism of proteins
R-HSA-1268020 Mitochondrial protein import
R-HSA-1430728 Metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-422356 Regulation of insulin secretion
WikiPathways
WP111 Electron Transport Chain
WP706 SIDS Susceptibility Pathways
WP2267 Synaptic Vesicle Pathway


Homo sapiens (human) SLC25A4 NP_001142.2
Pan troglodytes (chimpanzee) SLC25A4 XP_517556.3
Macaca mulatta (Rhesus monkey) SLC25A4 XP_001084544.1
Canis lupus familiaris (dog) SLC25A4 XP_532844.2
Bos taurus (cattle) SLC25A4 NP_777083.1
Mus musculus (house mouse) Slc25a4 NP_031476.3
Rattus norvegicus (Norway rat) Slc25a4 NP_445967.1
Gallus gallus (chicken) SLC25A4 NP_001006443.1
Danio rerio (zebrafish) slc25a4 NP_999867.1
Drosophila melanogaster (fruit fly) sesB NP_727448.1
Xenopus (Silurana) tropicalis (western clawed frog) slc25a4 NP_988909.1

Component

ID Name Evidence
GO:0005739 mitochondrion IEA
GO:0005741 mitochondrial outer membrane IEA
GO:0005743 mitochondrial inner membrane EXP
GO:0005743 mitochondrial inner membrane TAS
GO:0005887 integral to plasma membrane TAS
GO:0016020 membrane IEA

Function

ID Name Evidence
GO:0005215 transporter activity IEA
GO:0005471 ATP:ADP antiporter activity IEA
GO:0005515 protein binding IPI
GO:0015207 adenine transmembrane transporter activity TAS

Process

ID Name Evidence
GO:0000002 mitochondrial genome maintenance TAS
GO:0006091 generation of precursor metabolites and energy TAS
GO:0006112 energy reserve metabolic process TAS
GO:0006810 transport TAS
GO:0008637 apoptotic mitochondrial changes IEA
GO:0015853 adenine transport TAS
GO:0015866 ADP transport IEA
GO:0015867 ATP transport IEA
GO:0016032 viral reproduction TAS
GO:0044419 interspecies interaction between organisms IEA
GO:0050796 regulation of insulin secretion TAS
GO:0051935 glutamate uptake involved in synaptic transmission IEA
GO:0055085 transmembrane transport IEA
GO:0060547 negative regulation of necrotic cell death IMP

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLC25A4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC25A4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22413
NM_001151 Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $99.50
$199.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu22413
Accession Version NM_001151.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 897bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 16-JUL-2015
Organism Homo sapiens (human)
Product ADP/ATP translocase 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI544547.1, BC008664.1, AC093824.3, AC112237.1 and AC093592.3. This sequence is a reference standard in the RefSeqGene project. On Sep 15, 2009 this sequence version replaced gi:55749576. Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008664.1, J02966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGGTGATC ACGCTTGGAG CTTCCTAAAG GACTTCCTGG CCGGGGGCGT CGCCGCTGCC 
GTCTCCAAGA CCGCGGTCGC CCCCATCGAG AGGGTCAAAC TGCTGCTGCA GGTCCAGCAT
GCCAGCAAAC AGATCAGTGC TGAGAAGCAG TACAAAGGGA TCATTGATTG TGTGGTGAGA
ATCCCTAAGG AGCAGGGCTT CCTCTCCTTC TGGAGGGGTA ACCTGGCCAA CGTGATCCGT
TACTTCCCCA CCCAAGCTCT CAACTTCGCC TTCAAGGACA AGTACAAGCA GCTCTTCTTA
GGGGGTGTGG ATCGGCATAA GCAGTTCTGG CGCTACTTTG CTGGTAACCT GGCGTCCGGT
GGGGCCGCTG GGGCCACCTC CCTTTGCTTT GTCTACCCGC TGGACTTTGC TAGGACCAGG
TTGGCTGCTG ATGTGGGCAA GGGCGCCGCC CAGCGTGAGT TCCATGGTCT GGGCGACTGT
ATCATCAAGA TCTTCAAGTC TGATGGCCTG AGGGGGCTCT ACCAGGGTTT CAACGTCTCT
GTCCAAGGCA TCATTATCTA TAGAGCTGCC TACTTCGGAG TCTATGATAC TGCCAAGGGG
ATGCTGCCTG ACCCCAAGAA CGTGCACATT TTTGTGAGCT GGATGATTGC CCAGAGTGTG
ACGGCAGTCG CAGGGCTGGT GTCCTACCCC TTTGACACTG TTCGTCGTAG AATGATGATG
CAGTCCGGCC GGAAAGGGGC CGATATTATG TACACGGGGA CAGTTGACTG CTGGAGGAAG
ATTGCAAAAG ACGAAGGAGC CAAGGCCTTC TTCAAAGGTG CCTGGTCCAA TGTGCTGAGA
GGCATGGGCG GTGCTTTTGT ATTGGTGTTG TATGATGAGA TCAAAAAATA TGTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001142.2
CDS111..1007
Misc Feature(1)90..92(+)
Misc Feature(2)114..116(+)
Misc Feature(3)123..227(+)
Misc Feature(4)126..404(+)
Misc Feature(5)129..1004(+)
Misc Feature(6)129..413(+)
Misc Feature(7)333..410(+)
Misc Feature(8)435..539(+)
Misc Feature(9)438..728(+)
Misc Feature(10)441..713(+)
Misc Feature(11)549..551(+)
Misc Feature(12)588..590(+)
Misc Feature(13)636..716(+)
Misc Feature(14)729..833(+)
Misc Feature(15)744..1001(+)
Misc Feature(16)774..1001(+)
Misc Feature(17)813..830(+)
Misc Feature(18)843..845(+)
Misc Feature(19)924..926(+)
Misc Feature(20)927..1004(+)
Exon (1)1..221
Gene:SLC25A4
Gene Synonym:
Exon (2)222..708
Gene:SLC25A4
Gene Synonym:
Exon (3)709..849
Gene:SLC25A4
Gene Synonym:
Exon (4)850..4420
Gene:SLC25A4
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:3733651
8 8 a, c, t dbSNP:190592847
22 22 a, g dbSNP:572672979
27 27 a, c, t dbSNP:183128370
28 28 a, g dbSNP:564798562
61 61 c, g dbSNP:769979832
63 63 a, g dbSNP:530876685
65 65 a, c, g dbSNP:763271934
82 82 c, t dbSNP:774601405
86 86 a, g dbSNP:3733652
95 95 c, g dbSNP:200276407
96 96 c, t dbSNP:752939660
114 114 a, g dbSNP:11555894
131 131 c, t dbSNP:753183212
152 152 c, g dbSNP:755681315
166 166 c, t dbSNP:11555895
170 170 a, c dbSNP:763593018
176 176 c, t dbSNP:753281657
183 183 a, g dbSNP:560967545
185 185 c, g dbSNP:778584154
202 202 a, g dbSNP:780727153
224 224 c, g dbSNP:199833605
250 250 c, t dbSNP:753373786
252 252 c, g dbSNP:201501984
255 255 a, c dbSNP:764843408
264 264 a, g dbSNP:750074843
269 269 g, t dbSNP:758192208
274 274 c, t dbSNP:779998539
278 278 c, t dbSNP:150481751
282 282 g, t dbSNP:1042560
287 287 g, t dbSNP:754987838
296 296 c, t dbSNP:781236208
337 337 c, t dbSNP:749367984
338 338 c, t dbSNP:562465418
347 347 c, t dbSNP:771022858
353 353 c, t dbSNP:779064025
362 362 c, t dbSNP:145413043
377 377 c, t dbSNP:148815021
402 402 c, g dbSNP:775849814
403 403 c, t dbSNP:104893876
404 404 a, c, g dbSNP:11555896
412 412 c, g, t dbSNP:192213532
421 421 a, g dbSNP:28999114
423 423 c, t dbSNP:761284377
427 427 a, g dbSNP:764796923
441 441 a, c, t dbSNP:375543860
442 442 a, g, t dbSNP:200739996
449 449 c, t dbSNP:751431997
450 450 c, g dbSNP:104893873
455 455 c, t dbSNP:368932623
459 459 c, t dbSNP:143457362
463 463 c, t dbSNP:781329565
464 464 a, g, t dbSNP:199887868
467 467 c, t dbSNP:779188276
469 469 a, g dbSNP:746131481
476 476 c, t dbSNP:528026040
478 478 a, c dbSNP:121912683
485 485 c, t dbSNP:780142859
507 507 a, c dbSNP:747469430
511 511 c, t dbSNP:769167616
520 520 c, g dbSNP:776796321
524 524 a, g dbSNP:762235718
530 530 a, g, t dbSNP:770115085
545 545 g, t dbSNP:762735406
550 550 a, c, g dbSNP:765947532
551 551 a, g dbSNP:759487162
554 554 c, t dbSNP:767493198
556 556 -, c dbSNP:62620230
557 557 c, g, t dbSNP:752640906
569 569 a, g dbSNP:777474737
581 581 c, g dbSNP:750623733
585 585 a, g dbSNP:372537665
591 591 a, g dbSNP:137936792
597 597 a, t dbSNP:780055096
600 600 a, g dbSNP:143511445
609 609 a, t dbSNP:375855227
611 611 a, t dbSNP:755119669
621 621 -, g dbSNP:745347282
624 624 g, t dbSNP:781716627
626 626 a, g dbSNP:145904515
642 642 a, t dbSNP:770164502
643 643 a, t dbSNP:773480426
644 644 c, t dbSNP:748899339
656 656 a, g dbSNP:770719053
668 668 c, t dbSNP:773929603
677 677 c, t dbSNP:149101873
679 679 c, t dbSNP:766991064
680 680 c, g dbSNP:775472251
699 699 a, g dbSNP:760565432
707 707 g, t dbSNP:763904371
711 711 a, g dbSNP:767637048
716 716 c, g dbSNP:753029385
724 724 c, g dbSNP:376071284
727 727 a, g dbSNP:764315698
729 729 a, t dbSNP:754363197
731 731 c, t dbSNP:757866751
732 732 a, g dbSNP:779367539
739 739 a, t dbSNP:750762583
752 752 c, g dbSNP:202196466
758 758 c, t dbSNP:758868244
761 761 a, c dbSNP:368649185
772 772 c, t dbSNP:772143131
773 773 a, c, g dbSNP:746726936
777 777 a, g dbSNP:562561969
780 780 a, g, t dbSNP:748031233
788 788 a, g dbSNP:772924807
791 791 a, g dbSNP:34486484
816 816 c, g dbSNP:55820580
817 817 a, g dbSNP:770816416
819 819 a, c dbSNP:775550324
836 836 c, t dbSNP:760995481
837 837 a, g dbSNP:764225621
847 847 c, g dbSNP:753986455
851 851 c, t dbSNP:776229952
852 852 a, c, g dbSNP:755597294
865 865 c, t dbSNP:753197100
866 866 a, g dbSNP:150786764
892 892 c, t dbSNP:778510320
902 902 c, t dbSNP:185542833
903 903 a, g dbSNP:772055424
910 910 c, t dbSNP:776973147
914 914 c, g dbSNP:748424743
921 921 c, t dbSNP:769723484
938 938 c, t dbSNP:764941953
959 959 c, t dbSNP:374918344
960 960 a, g dbSNP:756745748
971 971 a, g dbSNP:763311034
975 975 a, g dbSNP:104893874
977 977 g, t dbSNP:771474644
978 978 g, t dbSNP:774787245
992 992 a, c dbSNP:142164891
998 998 -, at dbSNP:751852654
998 998 a, g dbSNP:767916049
1003 1003 c, t dbSNP:752314517
1008 1008 c, t dbSNP:762824820
1014 1014 c, t dbSNP:566181210
1018 1018 -, ac dbSNP:759526725
1021 1021 c, t dbSNP:763461907
1033 1033 c, t dbSNP:753397702
1036 1036 a, g dbSNP:757072560
1039 1039 -, g dbSNP:35645021
1095 1095 a, g dbSNP:763730709
1132 1132 a, c dbSNP:542187665
1140 1140 c, t dbSNP:1804551
1158 1158 c, t dbSNP:373871091
1180 1180 -, at dbSNP:112970805
1265 1265 -, ata dbSNP:542820181
1284 1284 c, t dbSNP:190251889
1305 1305 a, g dbSNP:547652281
1308 1308 c, t dbSNP:570755334
1309 1309 a, g dbSNP:112983771
1313 1313 -, t dbSNP:34804401
1330 1330 -, tta dbSNP:139462979
1344 1344 -, a dbSNP:34935621
1381 1381 c, t dbSNP:757138615
1437 1437 a, c dbSNP:375325238
1455 1455 a, g dbSNP:767635362
1466 1466 a, g dbSNP:554157417
1472 1472 a, c dbSNP:755819590
1488 1488 g, t dbSNP:78882199
1493 1493 a, g, t dbSNP:535455404
1499 1499 -, tcta dbSNP:551018560
1499 1499 g, t dbSNP:555000462
1504 1504 g, t dbSNP:562129249
1512 1512 a, t dbSNP:371951997
1518 1518 ca, tg dbSNP:386683346
1518 1518 c, t dbSNP:146348453
1519 1519 a, g dbSNP:7660552
1571 1571 a, g dbSNP:12510225
1578 1578 g, t dbSNP:370688019
1644 1644 a, g dbSNP:543721367
1678 1678 a, g dbSNP:181474745
1684 1684 a, g dbSNP:573902133
1704 1704 c, t dbSNP:543016248
1710 1710 -, ag dbSNP:148316877
1718 1718 g, t dbSNP:369987831
1722 1722 c, t dbSNP:528642216
1726 1726 a, c dbSNP:755370485
1755 1755 c, t dbSNP:374390916
1785 1785 c, t dbSNP:547591737
1831 1831 c, t dbSNP:779103031
1880 1880 a, g dbSNP:76680834
1884 1884 c, t dbSNP:533168389
1885 1885 a, g dbSNP:772681722
1941 1941 a, g dbSNP:375946025
1964 1964 c, t dbSNP:11930741
1977 1977 c, t dbSNP:373002113
1989 1989 c, g dbSNP:569936292
1995 1995 a, c dbSNP:376527654
1996 1996 a, g dbSNP:577894228
2017 2017 -, aaaa dbSNP:374044101
2017 2017 -, a dbSNP:750786134
2060 2060 c, t dbSNP:55905558
2063 2063 c, t dbSNP:772056683
2064 2064 a, g dbSNP:548612019
2065 2065 a, t dbSNP:544431844
2075 2075 -, tgta dbSNP:773264349
2089 2089 c, t dbSNP:565436147
2103 2103 a, g dbSNP:534443341
2104 2104 a, c dbSNP:557445191
2123 2123 c, t dbSNP:149652815
2153 2153 c, t dbSNP:537652975
2197 2197 c, t dbSNP:557329867
2198 2198 a, g dbSNP:574316706
2251 2251 c, t dbSNP:542650972
2252 2252 a, t dbSNP:77959660
2311 2311 a, c dbSNP:769131737
2328 2328 a, c dbSNP:573359910
2393 2393 c, t dbSNP:113504038
2425 2425 c, t dbSNP:775216342
2506 2506 a, g dbSNP:545485040
2534 2534 c, t dbSNP:747297372
2553 2553 c, t dbSNP:762473759
2585 2585 c, t dbSNP:565400128
2660 2660 -, aaca dbSNP:534066505
2718 2718 a, g dbSNP:532936923
2769 2769 c, t dbSNP:371848308
2779 2779 c, t dbSNP:548570468
2799 2799 a, c dbSNP:3733653
2872 2872 -, tc dbSNP:556939314
2898 2898 a, g dbSNP:774112433
2899 2899 -, t dbSNP:771346297
2935 2935 a, c dbSNP:563429441
2951 2951 c, t dbSNP:527739402
2958 2958 c, t dbSNP:761777735
2959 2959 a, g dbSNP:767437135
2976 2976 c, g dbSNP:771109823
2992 2992 c, t dbSNP:3733654
3011 3011 g, t dbSNP:760822641
3057 3057 a, g dbSNP:76364770
3170 3170 a, c dbSNP:766298724
3180 3180 a, t dbSNP:563366109
3258 3258 a, g dbSNP:573691175
3301 3301 a, g dbSNP:755103744
3314 3314 c, t dbSNP:2046535
3342 3342 a, g dbSNP:144378592
3357 3357 -, taat dbSNP:745979983
3370 3370 a, g dbSNP:753110221
3423 3423 c, t dbSNP:148726748
3442 3442 -, tc dbSNP:144440208
3445 3445 -, ct dbSNP:375487895
3462 3462 -, gtc dbSNP:562427962
3468 3468 c, t dbSNP:186955051
3473 3473 a, c dbSNP:142255349
3482 3482 c, t dbSNP:192241746
3483 3483 a, g dbSNP:76335670
3502 3502 c, t dbSNP:567840925
3508 3508 c, t dbSNP:536979202
3509 3509 c, g dbSNP:553719520
3536 3536 c, t dbSNP:113950388
3559 3559 a, g dbSNP:545423116
3580 3580 c, t dbSNP:558741813
3599 3599 c, t dbSNP:575736094
3600 3600 a, g dbSNP:543251823
3623 3623 c, t dbSNP:769378373
3635 3635 c, t dbSNP:563528635
3639 3639 c, g dbSNP:779383457
3679 3679 g, t dbSNP:529161085
3704 3704 c, t dbSNP:768164742
3711 3711 c, t dbSNP:556737965
3716 3716 a, g dbSNP:542483730
3719 3719 a, c dbSNP:765594520
3727 3727 a, g dbSNP:559222593
3808 3808 a, c dbSNP:71638135
3825 3825 c, t dbSNP:774196259
3831 3831 c, g dbSNP:371093501
3852 3852 c, t dbSNP:775862979
3867 3867 c, t dbSNP:187688343
3868 3868 a, c dbSNP:761581651
3869 3869 c, t dbSNP:551002442
3950 3950 a, g dbSNP:7675110
3975 3975 c, t dbSNP:530656942
3978 3978 a, g dbSNP:139929345
3984 3984 c, g dbSNP:574434894
3993 3993 a, g dbSNP:145248237
3995 3995 g, t dbSNP:368041673
4002 4002 c, g dbSNP:553656237
4021 4021 c, g dbSNP:567181746
4032 4032 a, g dbSNP:773137655
4077 4077 c, t dbSNP:539027516
4078 4078 a, g, t dbSNP:558959854
4117 4117 c, g dbSNP:116996106
4121 4121 a, c, t dbSNP:147626367
4122 4122 a, g dbSNP:189929266
4125 4125 c, t dbSNP:755875204
4126 4126 a, g dbSNP:376762770
4128 4128 c, t dbSNP:766108137
4129 4129 a, g dbSNP:140827011
4164 4164 c, t dbSNP:542420297
4173 4173 c, g dbSNP:759840559
4179 4179 g, t dbSNP:765546292
4186 4186 c, g dbSNP:752912280
4202 4202 c, t dbSNP:182549219
4211 4211 a, g dbSNP:559209892
4214 4214 c, t dbSNP:533345524
4253 4253 c, t dbSNP:528416282
4283 4283 c, t dbSNP:187103619
4300 4300 a, g dbSNP:764517871
4313 4313 c, t dbSNP:564927574
4315 4315 c, g dbSNP:530438950
4324 4324 a, g dbSNP:752130203
4412 4412 c, t dbSNP:549902846
4417 4417 c, t dbSNP:753481356

Target ORF information:

RefSeq Version NM_001151
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001151

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGGTGATC ACGCTTGGAG CTTCCTAAAG GACTTCCTGG CCGGGGGCGT CGCCGCTGCC 
GTCTCCAAGA CCGCGGTCGC CCCCATCGAG AGGGTCAAAC TGCTGCTGCA GGTCCAGCAT
GCCAGCAAAC AGATCAGTGC TGAGAAGCAG TACAAAGGGA TCATTGATTG TGTGGTGAGA
ATCCCTAAGG AGCAGGGCTT CCTCTCCTTC TGGAGGGGTA ACCTGGCCAA CGTGATCCGT
TACTTCCCCA CCCAAGCTCT CAACTTCGCC TTCAAGGACA AGTACAAGCA GCTCTTCTTA
GGGGGTGTGG ATCGGCATAA GCAGTTCTGG CGCTACTTTG CTGGTAACCT GGCGTCCGGT
GGGGCCGCTG GGGCCACCTC CCTTTGCTTT GTCTACCCGC TGGACTTTGC TAGGACCAGG
TTGGCTGCTG ATGTGGGCAA GGGCGCCGCC CAGCGTGAGT TCCATGGTCT GGGCGACTGT
ATCATCAAGA TCTTCAAGTC TGATGGCCTG AGGGGGCTCT ACCAGGGTTT CAACGTCTCT
GTCCAAGGCA TCATTATCTA TAGAGCTGCC TACTTCGGAG TCTATGATAC TGCCAAGGGG
ATGCTGCCTG ACCCCAAGAA CGTGCACATT TTTGTGAGCT GGATGATTGC CCAGAGTGTG
ACGGCAGTCG CAGGGCTGGT GTCCTACCCC TTTGACACTG TTCGTCGTAG AATGATGATG
CAGTCCGGCC GGAAAGGGGC CGATATTATG TACACGGGGA CAGTTGACTG CTGGAGGAAG
ATTGCAAAAG ACGAAGGAGC CAAGGCCTTC TTCAAAGGTG CCTGGTCCAA TGTGCTGAGA
GGCATGGGCG GTGCTTTTGT ATTGGTGTTG TATGATGAGA TCAAAAAATA TGTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians
Neurobiol. Aging 35 (7), 1779 (2014)
He YH, Lu X, Wu H, Cai WW, Yang LQ, Xu LY, Sun HP and Kong QP.


book

Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation
Biochemistry 53 (23), 3817-3829 (2014)
Mielke C, Lefort N, McLean CG, Cordova JM, Langlais PR, Bordner AJ, Te JA, Ozkan SB, Willis WT and Mandarino LJ.


book

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
Cell 157 (2), 472-485 (2014)
Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM and Dawson VL.


book

Adenine nucleotide translocase 1 expression affects enterovirus infection in human and murine hearts
Int. J. Cardiol. 172 (3), E449-E452 (2014)
Kuhl U, Ebermann L, Lassner D, Klingel K, Klumpe I, Winter J, Zeichhardt H, Schultheiss HP and Dorner A.


book

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup
Proc. Natl. Acad. Sci. U.S.A. 110 (9), 3453-3458 (2013)
Strauss KA, DuBiner L, Simon M, Zaragoza M, Sengupta PP, Li P, Narula N, Dreike S, Platt J, Procaccio V, Ortiz-Gonzalez XR, Puffenberger EG, Kelley RI, Morton DH, Narula J and Wallace DC.


book

Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization
Cytogenet. Cell Genet. 60 (1), 29-30 (1992)
Fan YS, Yang HM and Lin CC.


book

A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed
J. Biol. Chem. 264 (24), 13998-14004 (1989)
Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N and Wallace DC.


book

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase
J. Mol. Biol. 206 (2), 261-280 (1989)
Cozens AL, Runswick MJ and Walker JE.


book

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver
Proc. Natl. Acad. Sci. U.S.A. 85 (2), 377-381 (1988)
Houldsworth J and Attardi G.


book

cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes
Proc. Natl. Acad. Sci. U.S.A. 84 (21), 7580-7584 (1987)
Neckelmann N, Li K, Wade RP, Shuster R and Wallace DC.


 
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