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CXCL1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CXCL1
Entrez Gene ID 2919
Full Name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Synonyms FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
General protein information
Preferred Names
growth-regulated alpha protein
Names
growth-regulated alpha protein
MGSA alpha
GRO-alpha(1-73)
C-X-C motif chemokine 1
fibroblast secretory protein
neutrophil-activating protein 3
melanoma growth stimulatory activity alpha
GRO1 oncogene (melanoma growth-stimulating activity)
GRO1 oncogene (melanoma growth stimulating activity, alpha)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

155730


mRNA and Protein(s)

mRNA Protein Name
NM_001511 NP_001502 growth-regulated alpha protein precursor



Homo sapiens (human) CXCL1 NP_001502.1
Pan troglodytes (chimpanzee) CXCL1 XP_003950376.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CXCL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21597
NM_001511 Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21597
Clone ID Related Accession (Same CDS sequence) NM_001511
Accession Version NM_001511.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product growth-regulated alpha protein precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092438.5, BM554448.1 and BM996663.1. On Jan 21, 2012 this sequence version replaced gi:292781859. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BP337543.1, BC011976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCGCG CTGCTCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG AGTGGCACTG 
CTGCTCCTGC TCCTGGTAGC CGCTGGCCGG CGCGCAGCAG GAGCGTCCGT GGCCACTGAA
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC CCAAGAACAT CCAAAGTGTG
AACGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGCGGAAAG CTTGCCTCAA TCCTGCATCC CCCATAGTTA AGAAAATCAT CGAAAAGATG
CTGAACAGTG ACAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001502.1
CDS80..403
Misc Feature(1)197..385(+)
Misc Feature(2)197..364(+)
Misc Feature(3)197..205(+)
Misc Feature(4)200..382(+)
Misc Feature(5)200..328(+)
Misc Feature(6)200..202(+)
Misc Feature(7)203..214(+)
Misc Feature(8)209..250(+)
Misc Feature(9)215..331(+)
Misc Feature(10)236..385(+)
Misc Feature(11)242..328(+)
Misc Feature(12)248..382(+)
Misc Feature(13)263..265(+)
Misc Feature(14)275..283(+)
Misc Feature(15)275..283(+)
Misc Feature(16)314..322(+)
Exon (1)1..179
Gene:CXCL1
Gene Synonym:
Exon (2)180..303
Gene:CXCL1
Gene Synonym:
Exon (3)304..387
Gene:CXCL1
Gene Synonym:
Exon (4)388..1169
Gene:CXCL1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001511
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001511

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCGCG CTGCTCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG AGTGGCACTG 
CTGCTCCTGC TCCTGGTAGC CGCTGGCCGG CGCGCAGCAG GAGCGTCCGT GGCCACTGAA
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC CCAAGAACAT CCAAAGTGTG
AACGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGCGGAAAG CTTGCCTCAA TCCTGCATCC CCCATAGTTA AGAAAATCAT CGAAAAGATG
CTGAACAGTG ACAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines
J. Immunol. 193 (3), 1416-1426 (2014)
Al-Alwan LA, Chang Y, Rousseau S, Martin JG, Eidelman DH and Hamid Q.


book

CXCL1/CXCL8 (GROalpha/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro
Am. J. Physiol. Endocrinol. Metab. 306 (9), E1077-E1084 (2014)
Omatsu T, Cepinskas G, Clarson C, Patterson EK, Alharfi IM, Summers K, Couraud PO, Romero IA, Weksler B and Fraser DD.


book

CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Clin. Lab. 60 (1), 99-104 (2014)
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M and Hassanshahi G.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Physical mapping of the CXC chemokine locus on human chromosome 4
Cytogenet. Cell Genet. 84 (1-2), 39-42 (1999)
O'Donovan N, Galvin M and Morgan JG.


book

Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA). Evidence for a novel MGSA receptor
J. Biol. Chem. 268 (1), 541-546 (1993)
Horuk R, Yansura DG, Reilly D, Spencer S, Bourell J, Henzel W, Rice G and Unemori E.


book

Characterization of two high affinity human interleukin-8 receptors
J. Biol. Chem. 267 (23), 16283-16287 (1992)
Lee J, Horuk R, Rice GC, Bennett GL, Camerato T and Wood WI.


book

An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblasts
J. Immunol. 147 (2), 520-527 (1991)
Anisowicz A, Messineo M, Lee SW and Sager R.


book

Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene
Nucleic Acids Res. 18 (21), 6453 (1990)
Baker NE, Kucera G and Richmond A.


book

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin
EMBO J. 7 (7), 2025-2033 (1988)
Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U and Derynck R.


 
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