||ORF Nucleotide Sequence (Length: 324bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||growth-regulated alpha protein precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC092438.5, BM554448.1 and
On Jan 21, 2012 this sequence version replaced gi:292781859.
Summary: This antimicrobial gene encodes a member of the CXC
subfamily of chemokines. The encoded protein is a secreted growth
factor that signals through the G-protein coupled receptor, CXC
receptor 2. This protein plays a role in inflammation and as a
chemoattractant for neutrophils. Aberrant expression of this
protein is associated with the growth and progression of certain
tumors. A naturally occurring processed form of this protein has
increased chemotactic activity. Alternate splicing results in
coding and non-coding variants of this gene. A pseudogene of this
gene is found on chromosome 4. [provided by RefSeq, Sep 2014].
Transcript Variant: This variant (1) encodes the functional
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Protein has antimicrobial activity :: PMID: 12949249
Transcript exon combination :: BP337543.1, BC011976.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.