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CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [Homo sapiens (human)]

Gene Symbol CXCL1
Entrez Gene ID 2919
Full Name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Synonyms FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
General protein information
Preferred Names
growth-regulated alpha protein
Names
growth-regulated alpha protein
MGSA alpha
GRO-alpha(1-73)
C-X-C motif chemokine 1
fibroblast secretory protein
neutrophil-activating protein 3
melanoma growth stimulatory activity alpha
GRO1 oncogene (melanoma growth-stimulating activity)
GRO1 oncogene (melanoma growth stimulating activity, alpha)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

155730

Disorder Html:





The following CXCL1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21597 NM_001511 Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu21597
Accession Version NM_001511.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu21597D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product growth-regulated alpha protein precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092438.5, BM554448.1 and BM996663.1. On Jan 21, 2012 this sequence version replaced gi:292781859. Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BP337543.1, BC011976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCGCG CTGCTCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG AGTGGCACTG 
CTGCTCCTGC TCCTGGTAGC CGCTGGCCGG CGCGCAGCAG GAGCGTCCGT GGCCACTGAA
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC CCAAGAACAT CCAAAGTGTG
AACGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGCGGAAAG CTTGCCTCAA TCCTGCATCC CCCATAGTTA AGAAAATCAT CGAAAAGATG
CTGAACAGTG ACAAATCCAA CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001502.1
CDS80..403
Misc Feature(1)197..385(+)
Misc Feature(2)197..364(+)
Misc Feature(3)197..205(+)
Misc Feature(4)200..382(+)
Misc Feature(5)200..328(+)
Misc Feature(6)200..202(+)
Misc Feature(7)203..214(+)
Misc Feature(8)209..250(+)
Misc Feature(9)215..331(+)
Misc Feature(10)236..385(+)
Misc Feature(11)242..328(+)
Misc Feature(12)248..382(+)
Misc Feature(13)263..265(+)
Misc Feature(14)275..283(+)
Misc Feature(15)275..283(+)
Misc Feature(16)314..322(+)
Exon (1)1..179
Gene:CXCL1
Gene Synonym:
Exon (2)180..303
Gene:CXCL1
Gene Synonym:
Exon (3)304..387
Gene:CXCL1
Gene Synonym:
Exon (4)388..1169
Gene:CXCL1
Gene Synonym:
Translation
Position Chain Variation Link
16 16 a, g dbSNP:201096356
20 20 a, g dbSNP:543932397
23 23 c, g dbSNP:202228146
34 34 a, g dbSNP:750209843
40 40 c, g dbSNP:755816985
42 42 g, t dbSNP:11547681
45 45 a, c dbSNP:752846210
46 46 c, g dbSNP:201103048
54 54 a, g dbSNP:201839321
55 55 a, c dbSNP:747160402
67 67 c, t dbSNP:771399946
75 75 g, t dbSNP:781601333
87 87 a, g, t dbSNP:200382055
88 88 c, t dbSNP:770014238
91 91 c, t dbSNP:775928119
92 92 a, g dbSNP:762637615
94 94 g, t dbSNP:768482831
95 95 c, t dbSNP:773966205
105 105 c, t dbSNP:761456939
106 106 c, t dbSNP:767076337
109 109 c, t dbSNP:201063147
110 110 a, g dbSNP:760662270
112 112 a, c dbSNP:766026812
118 118 a, c dbSNP:199632051
119 119 a, c dbSNP:758617785
120 120 g, t dbSNP:778012847
128 128 a, c dbSNP:751619422
129 129 g, t dbSNP:541081060
130 130 a, g dbSNP:201090116
131 131 a, g dbSNP:746294684
136 136 a, g dbSNP:2071425
139 139 -, ctgctc dbSNP:762193840
139 139 a, g dbSNP:529847960
140 140 c, t dbSNP:375785063
141 141 c, t dbSNP:780555004
149 149 a, c, t dbSNP:13104984
157 157 a, g dbSNP:199791199
161 161 g, t dbSNP:200543208
162 162 c, t dbSNP:531055521
163 163 c, t dbSNP:771412777
164 164 a, g dbSNP:772788390
168 168 a, g dbSNP:760514000
171 171 a, g dbSNP:548620036
172 172 a, c dbSNP:776382593
173 173 a, g dbSNP:759378371
174 174 c, t dbSNP:765043445
183 183 -, c dbSNP:773440951
185 185 c, t dbSNP:374657089
188 188 c, g dbSNP:754028324
190 190 a, g dbSNP:760115155
192 192 c, t dbSNP:201091698
203 203 c, g dbSNP:752979975
209 209 c, t dbSNP:758743363
223 223 a, c, t dbSNP:181868085
227 227 a, c dbSNP:200234866
229 229 g, t dbSNP:780671066
230 230 a, g dbSNP:745452423
238 238 a, c dbSNP:769691514
240 240 c, t dbSNP:779990786
244 244 g, t dbSNP:749211456
245 245 a, g dbSNP:768428003
249 249 c, t dbSNP:201545979
252 252 a, g dbSNP:760965523
253 253 a, g dbSNP:200728596
256 256 c, t dbSNP:199681383
259 259 a, g dbSNP:200474746
262 262 c, g dbSNP:201293315
263 263 a, c, g, t dbSNP:186092967
270 270 a, c, g dbSNP:751931366
271 271 c, t dbSNP:767200282
272 272 a, c, t dbSNP:201878466
274 274 c, t dbSNP:779431090
281 281 c, g dbSNP:749188314
282 282 a, g dbSNP:754924062
285 285 a, g dbSNP:778764212
288 288 c, t dbSNP:145342393
292 292 a, g dbSNP:377357456
297 297 a, t dbSNP:190901425
302 302 a, c dbSNP:199785807
303 303 c, t dbSNP:746126781
310 310 a, c, t dbSNP:199795990
313 313 c, g dbSNP:780191003
320 320 c, g dbSNP:200169557
322 322 a, g, t dbSNP:768549135
323 323 a, c, t dbSNP:201545716
324 324 a, g dbSNP:773534431
327 327 a, t dbSNP:760994074
340 340 a, t dbSNP:199676312
347 347 a, t dbSNP:771347748
355 355 a, g dbSNP:776106343
370 370 c, g dbSNP:759232302
371 371 a, g dbSNP:201003859
373 373 a, g dbSNP:752313297
377 377 a, g dbSNP:201361001
383 383 a, g dbSNP:762980706
385 385 a, c, t dbSNP:549189473
386 386 a, g dbSNP:199517728
389 389 a, g dbSNP:748982870
397 397 c, t dbSNP:768218800
400 400 c, t dbSNP:773967165
406 406 a, c dbSNP:373235955
408 408 -, a dbSNP:766774591
412 412 a, g dbSNP:767526268
413 413 a, g dbSNP:200352624
417 417 a, g dbSNP:568899629
418 418 g, t dbSNP:199722074
421 421 a, c, g dbSNP:766192146
422 422 a, c dbSNP:758632016
426 426 c, t dbSNP:764068835
427 427 c, t dbSNP:751730223
435 435 a, g dbSNP:369856007
436 436 c, t dbSNP:781747461
438 438 c, t dbSNP:746403404
449 449 c, g dbSNP:756509914
503 503 -, g dbSNP:34849214
522 522 c, t dbSNP:772601219
531 531 a, g dbSNP:377299803
569 569 a, g dbSNP:548540699
583 583 a, g dbSNP:148368837
596 596 a, g dbSNP:533992459
627 627 a, c dbSNP:553150230
674 674 c, t dbSNP:578065961
696 696 a, t dbSNP:538778784
714 714 c, t dbSNP:757128461
745 745 c, t dbSNP:762690344
751 751 c, t dbSNP:766192794
785 785 c, t dbSNP:113554285
795 795 -, g dbSNP:375408676
799 799 a, g dbSNP:371415385
801 801 a, g dbSNP:200339008
841 841 attcccttctt, gaatgtatgtgca dbSNP:386676045
841 841 -, ga dbSNP:566583028
853 853 -, ccttctt dbSNP:373569191
853 853 a, g dbSNP:112791438
863 863 c, t dbSNP:111913680
864 864 g, t dbSNP:116303802
951 951 c, g dbSNP:556105521
1038 1038 a, g dbSNP:542911276
1055 1055 c, t dbSNP:1957068
1065 1065 g, t dbSNP:573316994
1112 1112 c, g dbSNP:540839136
1133 1133 a, c dbSNP:544472543
1148 1148 a, c dbSNP:183378609
1162 1162 a, g dbSNP:532221985
1164 1164 c, t dbSNP:111301726
1167 1167 a, c dbSNP:562459448

Target ORF information:

RefSeq Version NM_001511
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001511

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCGCG CTGCTCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG AGTGGCACTG 
CTGCTCCTGC TCCTGGTAGC CGCTGGCCGG CGCGCAGCAG GAGCGTCCGT GGCCACTGAA
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC CCAAGAACAT CCAAAGTGTG
AACGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGCGGAAAG CTTGCCTCAA TCCTGCATCC CCCATAGTTA AGAAAATCAT CGAAAAGATG
CTGAACAGTG ACAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.