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CXCL3 chemokine (C-X-C motif) ligand 3 [Homo sapiens (human)]

Gene Symbol CXCL3
Entrez Gene ID 2921
Full Name chemokine (C-X-C motif) ligand 3
Synonyms CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
General protein information
Preferred Names
C-X-C motif chemokine 3
Names
C-X-C motif chemokine 3
GRO-gamma
MIP2-beta
MGSA gamma
GRO3 oncogene
GRO-gamma(1-73)
growth-regulated protein gamma
macrophage inflammatory protein 2-beta
melanoma growth stimulatory activity gamma
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

139111

Disorder Html:





The following CXCL3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu03827 NM_002090 Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu03827
Accession Version NM_002090.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-X-C motif chemokine 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM828712.1, BC065743.1 and AW079760.1. On Oct 15, 2004 this sequence version replaced gi:4504156. Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: CN263767.1, BC065743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA
CTGAACAAGG GGAGCACCAA CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002081.2
CDS163..486
Misc Feature(1)280..468(+)
Misc Feature(2)280..447(+)
Misc Feature(3)280..288(+)
Misc Feature(4)283..465(+)
Misc Feature(5)283..411(+)
Misc Feature(6)286..297(+)
Misc Feature(7)292..333(+)
Misc Feature(8)298..414(+)
Misc Feature(9)319..468(+)
Misc Feature(10)325..411(+)
Misc Feature(11)331..465(+)
Misc Feature(12)358..366(+)
Misc Feature(13)358..366(+)
Misc Feature(14)397..405(+)
Exon (1)1..262
Gene:CXCL3
Gene Synonym:
Exon (2)263..386
Gene:CXCL3
Gene Synonym:
Exon (3)387..470
Gene:CXCL3
Gene Synonym:
Exon (4)471..1159
Gene:CXCL3
Gene Synonym:
Translation
Position Chain Variation Link
31 31 a, c dbSNP:201152033
49 49 c, t dbSNP:566891033
79 79 a, g dbSNP:200492242
87 87 a, c dbSNP:199782009
91 91 c, t dbSNP:201480179
103 103 a, g dbSNP:555095760
113 113 a, g dbSNP:200362235
129 129 c, t dbSNP:201936501
149 149 g, t dbSNP:568243232
167 167 a, c dbSNP:550117892
170 170 a, g dbSNP:352043
172 172 c, g dbSNP:200464221
173 173 c, g dbSNP:570431901
195 195 a, c dbSNP:182216932
207 207 c, t dbSNP:751227846
211 211 a, c, t dbSNP:189466801
213 213 g, t dbSNP:559863732
215 215 a, t dbSNP:765601099
219 219 g, t dbSNP:199829667
253 253 c, t dbSNP:776634963
260 260 c, t dbSNP:766477754
266 266 c, g, t dbSNP:767580060
270 270 c, t dbSNP:559192926
271 271 a, g dbSNP:200553995
272 272 c, t dbSNP:764966050
273 273 a, g dbSNP:759336580
275 275 c, t dbSNP:776438863
285 285 a, g dbSNP:770935452
287 287 g, t dbSNP:760681177
288 288 a, c dbSNP:772927599
290 290 a, g dbSNP:771679590
291 291 a, c dbSNP:747806816
297 297 c, t dbSNP:199499790
306 306 a, c dbSNP:139655860
310 310 a, c dbSNP:768904602
315 315 a, c dbSNP:200899993
325 325 a, c dbSNP:749604366
326 326 a, g dbSNP:780382958
334 334 c, t dbSNP:756681082
335 335 a, g dbSNP:372884271
337 337 a, t dbSNP:750896756
344 344 a, g dbSNP:369343727
345 345 c, g, t dbSNP:376832730
346 346 a, g dbSNP:751763259
348 348 a, g dbSNP:764311707
350 350 a, g dbSNP:759263459
352 352 a, g, t dbSNP:200035503
353 353 c, t dbSNP:200604462
354 354 a, c dbSNP:760736689
356 356 c, t dbSNP:773263184
357 357 c, t dbSNP:199744046
358 358 a, g dbSNP:771736648
359 359 a, g dbSNP:180805941
359 359 -, g dbSNP:764083321
363 363 c, t dbSNP:773884964
370 370 c, g dbSNP:200228799
372 372 c, g dbSNP:768409602
378 378 c, t dbSNP:748888221
379 379 a, g dbSNP:202147554
381 381 a, g dbSNP:770120324
393 393 a, c, t dbSNP:755983685
394 394 c, t dbSNP:750297189
405 405 a, g dbSNP:767207918
406 406 a, c dbSNP:757258068
408 408 g, t dbSNP:751429690
409 409 a, g dbSNP:763680466
412 412 g, t dbSNP:149422615
413 413 c, t dbSNP:775129846
415 415 c, t dbSNP:764813946
427 427 a, g dbSNP:759175981
428 428 c, t dbSNP:201940372
434 434 c, t dbSNP:771173483
437 437 a, t dbSNP:761297973
442 442 a, c dbSNP:773545719
453 453 a, c dbSNP:201123855
459 459 g, t dbSNP:748177839
462 462 a, g dbSNP:779120236
463 463 c, t dbSNP:769062676
464 464 c, t dbSNP:749486824
468 468 a, c, t dbSNP:779165994
471 471 a, g dbSNP:780096891
472 472 a, g dbSNP:770763315
474 474 a, g, t dbSNP:201340451
476 476 a, g dbSNP:758397992
481 481 a, g dbSNP:199913594
483 483 a, c dbSNP:778446314
485 485 a, g dbSNP:547742552
490 490 a, c, g dbSNP:368197936
499 499 a, c dbSNP:201571220
504 504 c, g dbSNP:200741239
506 506 g, t dbSNP:200096542
511 511 a, g dbSNP:535834853
513 513 a, c, t dbSNP:371129154
514 514 a, g, t dbSNP:201732413
520 520 c, t dbSNP:775795288
521 521 c, t dbSNP:185155671
522 522 a, g dbSNP:199810402
523 523 a, c dbSNP:746100992
524 524 c, t dbSNP:374315451
529 529 c, t dbSNP:201781698
534 534 a, g dbSNP:200611108
540 540 a, g dbSNP:199509809
551 551 c, t dbSNP:201483390
561 561 a, g dbSNP:200565678
571 571 a, c dbSNP:199753671
596 596 a, g dbSNP:565439920
597 597 a, g dbSNP:151083701
608 608 c, g dbSNP:201421057
618 618 c, t dbSNP:200262907
621 621 a, t dbSNP:528751164
632 632 c, t dbSNP:201879346
633 633 a, g dbSNP:200886112
639 639 a, t dbSNP:200253429
654 654 a, g dbSNP:746872412
689 689 a, g dbSNP:201791349
690 690 c, t dbSNP:201127219
713 713 a, g dbSNP:200151056
715 715 c, g dbSNP:202015979
748 748 a, c dbSNP:201055105
749 749 a, g dbSNP:199876137
759 759 a, g dbSNP:201862278
791 791 c, t dbSNP:112785228
800 800 c, g dbSNP:192662858
801 801 a, g dbSNP:13150258
819 819 c, g dbSNP:749418897
854 854 g, t dbSNP:543086648
868 868 c, t dbSNP:199743689
873 873 a, t dbSNP:201735236
891 891 a, g dbSNP:200716830
898 898 a, g dbSNP:199778175
904 904 a, g dbSNP:538109513
925 925 a, t dbSNP:201623624
927 927 a, c dbSNP:200320368
937 937 -, t dbSNP:551729161
937 937 a, t dbSNP:199517714
938 938 a, t dbSNP:1051754
946 946 a, g dbSNP:113503574
956 956 g, t dbSNP:200396970
968 968 a, g dbSNP:201824210
983 983 c, t dbSNP:201068516
1000 1000 g, t dbSNP:200245948
1002 1002 c, t dbSNP:202150150
1008 1008 c, t dbSNP:201223860
1019 1019 c, t dbSNP:199936057
1025 1025 a, t dbSNP:201745827
1041 1041 a, g dbSNP:545469277
1049 1049 c, t dbSNP:200931739
1053 1053 a, g dbSNP:200113321
1071 1071 a, g dbSNP:570194772
1073 1073 c, t dbSNP:202023964
1074 1074 a, g dbSNP:200666836
1077 1077 c, t dbSNP:199844400
1078 1078 c, t dbSNP:370395758
1084 1084 c, g dbSNP:558671963
1085 1085 c, t dbSNP:182282902
1097 1097 g, t dbSNP:201853929
1116 1116 c, t dbSNP:200713242
1117 1117 a, g dbSNP:199783720
1118 1118 g, t dbSNP:201123122
1124 1124 a, c dbSNP:200490707
1126 1126 a, g dbSNP:199742726
1137 1137 a, t dbSNP:201654645
1138 1138 a, g dbSNP:200326371
1140 1140 a, g dbSNP:202111634
1142 1142 a, g dbSNP:201368914
1144 1144 g, t dbSNP:200470736
1150 1150 c, t dbSNP:202123605
1151 1151 -, a, g dbSNP:374617274

Target ORF information:

RefSeq Version NM_002090
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002090

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.