The following GSC2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSC2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 618bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||homeobox protein goosecoid-2
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U96402.1.
Summary: Goosecoidlike (GSCL), a homeodomain-containing gene,
resides in the critical region for VCFS/DGS on 22q11.
Velocardiofacial syndrome (VCFS) is a developmental disorder
characterized by conotruncal heart defects, craniofacial anomalies,
and learning disabilities. VCFS is phenotypically related to
DiGeorge syndrome (DGS) and both syndromes are associated with
hemizygous 22q11 deletions. Because many of the tissues and
structures affected in VCFS/DGS derive from the pharyngeal arches
of the developing embryo, it is believed that haploinsufficiency of
a gene involved in embryonic development may be responsible for its
etiology. The gene is expressed in a limited number of adult
tissues, as well as in early human development. [provided by
RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from genomic sequence
data because no single transcript was available for the full length
of the gene. The extent of this transcript is supported by
RNAseq introns :: mixed/partial sample support SAMEA1968968,