The following HBB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 444bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||hemoglobin subunit beta
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from L48217.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 11, 2003 this sequence version replaced gi:13788565.
Summary: The alpha (HBA) and beta (HBB) loci determine the
structure of the 2 types of polypeptide chains in adult hemoglobin,
Hb A. The normal adult hemoglobin tetramer consists of two alpha
chains and two beta chains. Mutant beta globin causes sickle cell
anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced
amounts of detectable beta globin causes beta-plus-thalassemia. The
order of the genes in the beta-globin cluster is 5'-epsilon --
gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: V00497.1, BU659180.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.