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HTT cDNA ORF clone, Homo sapiens (human)

Gene Symbol HTT
Entrez Gene ID 3064
Full Name huntingtin
Synonyms HD, IT15
General protein information
Preferred Names
huntingtin
Names
huntingtin
huntington disease protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16.3

Summary Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

613004

Disorder Html: Huntington disease, 143100 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_002111 NP_002102 huntingtin



Homo sapiens (human) HTT NP_002102.4
Pan troglodytes (chimpanzee) HTT XP_517080.4
Canis lupus familiaris (dog) HTT XP_536221.2
Bos taurus (cattle) HTT XP_002688476.1
Mus musculus (house mouse) Htt NP_034544.1
Rattus norvegicus (Norway rat) Htt NP_077333.2
Gallus gallus (chicken) HTT XP_420822.3
Danio rerio (zebrafish) htt NP_571093.1
Xenopus (Silurana) tropicalis (western clawed frog) htt NP_001007904.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HTT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23699 NM_002111 Homo sapiens huntingtin (HTT), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $1721.30
$2459.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23699
Clone ID Related Accession (Same CDS sequence) NM_002111
Accession Version NM_002111.7 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 9435bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product huntingtin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390059.10, L12392.1 and BC014028.2. On Feb 26, 2014 this sequence version replaced gi:90903230. Sequence Note: This RefSeq was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly except in the CAG repeat region. The reference genome has a repeat region encoding 21 glutamines while the RefSeq has a repeat region (nt 197-265) encoding 23. Neither repeat region is associated with Huntington's Disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## regulatory uORF :: PMID: 12466534 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: L12392.1, AB016794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
6841
6901
6961
7021
7081
7141
7201
7261
7321
7381
7441
7501
7561
7621
7681
7741
7801
7861
7921
7981
8041
8101
8161
8221
8281
8341
8401
8461
8521
8581
8641
8701
8761
8821
8881
8941
9001
9061
9121
9181
9241
9301
9361
9421
ATGGCGACCC TGGAAAAGCT GATGAAGGCC TTCGAGTCCC TCAAGTCCTT CCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAACAG
CCGCCACCGC CGCCGCCGCC GCCGCCGCCT CCTCAGCTTC CTCAGCCGCC GCCGCAGGCA
CAGCCGCTGC TGCCTCAGCC GCAGCCGCCC CCGCCGCCGC CCCCGCCGCC ACCCGGCCCG
GCTGTGGCTG AGGAGCCGCT GCACCGACCA AAGAAAGAAC TTTCAGCTAC CAAGAAAGAC
CGTGTGAATC ATTGTCTGAC AATATGTGAA AACATAGTGG CACAGTCTGT CAGAAATTCT
CCAGAATTTC AGAAACTTCT GGGCATCGCT ATGGAACTTT TTCTGCTGTG CAGTGATGAC
GCAGAGTCAG ATGTCAGGAT GGTGGCTGAC GAATGCCTCA ACAAAGTTAT CAAAGCTTTG
ATGGATTCTA ATCTTCCAAG GTTACAGCTC GAGCTCTATA AGGAAATTAA AAAGAATGGT
GCCCCTCGGA GTTTGCGTGC TGCCCTGTGG AGGTTTGCTG AGCTGGCTCA CCTGGTTCGG
CCTCAGAAAT GCAGGCCTTA CCTGGTGAAC CTTCTGCCGT GCCTGACTCG AACAAGCAAG
AGACCCGAAG AATCAGTCCA GGAGACCTTG GCTGCAGCTG TTCCCAAAAT TATGGCTTCT
TTTGGCAATT TTGCAAATGA CAATGAAATT AAGGTTTTGT TAAAGGCCTT CATAGCGAAC
CTGAAGTCAA GCTCCCCCAC CATTCGGCGG ACAGCGGCTG GATCAGCAGT GAGCATCTGC
CAGCACTCAA GAAGGACACA ATATTTCTAT AGTTGGCTAC TAAATGTGCT CTTAGGCTTA
CTCGTTCCTG TCGAGGATGA ACACTCCACT CTGCTGATTC TTGGCGTGCT GCTCACCCTG
AGGTATTTGG TGCCCTTGCT GCAGCAGCAG GTCAAGGACA CAAGCCTGAA AGGCAGCTTC
GGAGTGACAA GGAAAGAAAT GGAAGTCTCT CCTTCTGCAG AGCAGCTTGT CCAGGTTTAT
GAACTGACGT TACATCATAC ACAGCACCAA GACCACAATG TTGTGACCGG AGCCCTGGAG
CTGTTGCAGC AGCTCTTCAG AACGCCTCCA CCCGAGCTTC TGCAAACCCT GACCGCAGTC
GGGGGCATTG GGCAGCTCAC CGCTGCTAAG GAGGAGTCTG GTGGCCGAAG CCGTAGTGGG
AGTATTGTGG AACTTATAGC TGGAGGGGGT TCCTCATGCA GCCCTGTCCT TTCAAGAAAA
CAAAAAGGCA AAGTGCTCTT AGGAGAAGAA GAAGCCTTGG AGGATGACTC TGAATCGAGA
TCGGATGTCA GCAGCTCTGC CTTAACAGCC TCAGTGAAGG ATGAGATCAG TGGAGAGCTG
GCTGCTTCTT CAGGGGTTTC CACTCCAGGG TCAGCAGGTC ATGACATCAT CACAGAACAG
CCACGGTCAC AGCACACACT GCAGGCGGAC TCAGTGGATC TGGCCAGCTG TGACTTGACA
AGCTCTGCCA CTGATGGGGA TGAGGAGGAT ATCTTGAGCC ACAGCTCCAG CCAGGTCAGC
GCCGTCCCAT CTGACCCTGC CATGGACCTG AATGATGGGA CCCAGGCCTC GTCGCCCATC
AGCGACAGCT CCCAGACCAC CACCGAAGGG CCTGATTCAG CTGTTACCCC TTCAGACAGT
TCTGAAATTG TGTTAGACGG TACCGACAAC CAGTATTTGG GCCTGCAGAT TGGACAGCCC
CAGGATGAAG ATGAGGAAGC CACAGGTATT CTTCCTGATG AAGCCTCGGA GGCCTTCAGG
AACTCTTCCA TGGCCCTTCA ACAGGCACAT TTATTGAAAA ACATGAGTCA CTGCAGGCAG
CCTTCTGACA GCAGTGTTGA TAAATTTGTG TTGAGAGATG AAGCTACTGA ACCGGGTGAT
CAAGAAAACA AGCCTTGCCG CATCAAAGGT GACATTGGAC AGTCCACTGA TGATGACTCT
GCACCTCTTG TCCATTGTGT CCGCCTTTTA TCTGCTTCGT TTTTGCTAAC AGGGGGAAAA
AATGTGCTGG TTCCGGACAG GGATGTGAGG GTCAGCGTGA AGGCCCTGGC CCTCAGCTGT
GTGGGAGCAG CTGTGGCCCT CCACCCGGAA TCTTTCTTCA GCAAACTCTA TAAAGTTCCT
CTTGACACCA CGGAATACCC TGAGGAACAG TATGTCTCAG ACATCTTGAA CTACATCGAT
CATGGAGACC CACAGGTTCG AGGAGCCACT GCCATTCTCT GTGGGACCCT CATCTGCTCC
ATCCTCAGCA GGTCCCGCTT CCACGTGGGA GATTGGATGG GCACCATTAG AACCCTCACA
GGAAATACAT TTTCTTTGGC GGATTGCATT CCTTTGCTGC GGAAAACACT GAAGGATGAG
TCTTCTGTTA CTTGCAAGTT AGCTTGTACA GCTGTGAGGA ACTGTGTCAT GAGTCTCTGC
AGCAGCAGCT ACAGTGAGTT AGGACTGCAG CTGATCATCG ATGTGCTGAC TCTGAGGAAC
AGTTCCTATT GGCTGGTGAG GACAGAGCTT CTGGAAACCC TTGCAGAGAT TGACTTCAGG
CTGGTGAGCT TTTTGGAGGC AAAAGCAGAA AACTTACACA GAGGGGCTCA TCATTATACA
GGGCTTTTAA AACTGCAAGA ACGAGTGCTC AATAATGTTG TCATCCATTT GCTTGGAGAT
GAAGACCCCA GGGTGCGACA TGTTGCCGCA GCATCACTAA TTAGGCTTGT CCCAAAGCTG
TTTTATAAAT GTGACCAAGG ACAAGCTGAT CCAGTAGTGG CCGTGGCAAG AGATCAAAGC
AGTGTTTACC TGAAACTTCT CATGCATGAG ACGCAGCCTC CATCTCATTT CTCCGTCAGC
ACAATAACCA GAATATATAG AGGCTATAAC CTACTACCAA GCATAACAGA CGTCACTATG
GAAAATAACC TTTCAAGAGT TATTGCAGCA GTTTCTCATG AACTAATCAC ATCAACCACC
AGAGCACTCA CATTTGGATG CTGTGAAGCT TTGTGTCTTC TTTCCACTGC CTTCCCAGTT
TGCATTTGGA GTTTAGGTTG GCACTGTGGA GTGCCTCCAC TGAGTGCCTC AGATGAGTCT
AGGAAGAGCT GTACCGTTGG GATGGCCACA ATGATTCTGA CCCTGCTCTC GTCAGCTTGG
TTCCCATTGG ATCTCTCAGC CCATCAAGAT GCTTTGATTT TGGCCGGAAA CTTGCTTGCA
GCCAGTGCTC CCAAATCTCT GAGAAGTTCA TGGGCCTCTG AAGAAGAAGC CAACCCAGCA
GCCACCAAGC AAGAGGAGGT CTGGCCAGCC CTGGGGGACC GGGCCCTGGT GCCCATGGTG
GAGCAGCTCT TCTCTCACCT GCTGAAGGTG ATTAACATTT GTGCCCACGT CCTGGATGAC
GTGGCTCCTG GACCCGCAAT AAAGGCAGCC TTGCCTTCTC TAACAAACCC CCCTTCTCTA
AGTCCCATCC GACGAAAGGG GAAGGAGAAA GAACCAGGAG AACAAGCATC TGTACCGTTG
AGTCCCAAGA AAGGCAGTGA GGCCAGTGCA GCTTCTAGAC AATCTGATAC CTCAGGTCCT
GTTACAACAA GTAAATCCTC ATCACTGGGG AGTTTCTATC ATCTTCCTTC ATACCTCAAA
CTGCATGATG TCCTGAAAGC TACACACGCT AACTACAAGG TCACGCTGGA TCTTCAGAAC
AGCACGGAAA AGTTTGGAGG GTTTCTCCGC TCAGCCTTGG ATGTTCTTTC TCAGATACTA
GAGCTGGCCA CACTGCAGGA CATTGGGAAG TGTGTTGAAG AGATCCTAGG ATACCTGAAA
TCCTGCTTTA GTCGAGAACC AATGATGGCA ACTGTTTGTG TTCAACAATT GTTGAAGACT
CTCTTTGGCA CAAACTTGGC CTCCCAGTTT GATGGCTTAT CTTCCAACCC CAGCAAGTCA
CAAGGCCGAG CACAGCGCCT TGGCTCCTCC AGTGTGAGGC CAGGCTTGTA CCACTACTGC
TTCATGGCCC CGTACACCCA CTTCACCCAG GCCCTCGCTG ACGCCAGCCT GAGGAACATG
GTGCAGGCGG AGCAGGAGAA CGACACCTCG GGATGGTTTG ATGTCCTCCA GAAAGTGTCT
ACCCAGTTGA AGACAAACCT CACGAGTGTC ACAAAGAACC GTGCAGATAA GAATGCTATT
CATAATCACA TTCGTTTGTT TGAACCTCTT GTTATAAAAG CTTTAAAACA GTACACGACT
ACAACATGTG TGCAGTTACA GAAGCAGGTT TTAGATTTGC TGGCGCAGCT GGTTCAGTTA
CGGGTTAATT ACTGTCTTCT GGATTCAGAT CAGGTGTTTA TTGGCTTTGT ATTGAAACAG
TTTGAATACA TTGAAGTGGG CCAGTTCAGG GAATCAGAGG CAATCATTCC AAACATCTTT
TTCTTCTTGG TATTACTATC TTATGAACGC TATCATTCAA AACAGATCAT TGGAATTCCT
AAAATCATTC AGCTCTGTGA TGGCATCATG GCCAGTGGAA GGAAGGCTGT GACACATGCC
ATACCGGCTC TGCAGCCCAT AGTCCACGAC CTCTTTGTAT TAAGAGGAAC AAATAAAGCT
GATGCAGGAA AAGAGCTTGA AACCCAAAAA GAGGTGGTGG TGTCAATGTT ACTGAGACTC
ATCCAGTACC ATCAGGTGTT GGAGATGTTC ATTCTTGTCC TGCAGCAGTG CCACAAGGAG
AATGAAGACA AGTGGAAGCG ACTGTCTCGA CAGATAGCTG ACATCATCCT CCCAATGTTA
GCCAAACAGC AGATGCACAT TGACTCTCAT GAAGCCCTTG GAGTGTTAAA TACATTATTT
GAGATTTTGG CCCCTTCCTC CCTCCGTCCG GTAGACATGC TTTTACGGAG TATGTTCGTC
ACTCCAAACA CAATGGCGTC CGTGAGCACT GTTCAACTGT GGATATCGGG AATTCTGGCC
ATTTTGAGGG TTCTGATTTC CCAGTCAACT GAAGATATTG TTCTTTCTCG TATTCAGGAG
CTCTCCTTCT CTCCGTATTT AATCTCCTGT ACAGTAATTA ATAGGTTAAG AGATGGGGAC
AGTACTTCAA CGCTAGAAGA ACACAGTGAA GGGAAACAAA TAAAGAATTT GCCAGAAGAA
ACATTTTCAA GGTTTCTATT ACAACTGGTT GGTATTCTTT TAGAAGACAT TGTTACAAAA
CAGCTGAAGG TGGAAATGAG TGAGCAGCAA CATACTTTCT ATTGCCAGGA ACTAGGCACA
CTGCTAATGT GTCTGATCCA CATCTTCAAG TCTGGAATGT TCCGGAGAAT CACAGCAGCT
GCCACTAGGC TGTTCCGCAG TGATGGCTGT GGCGGCAGTT TCTACACCCT GGACAGCTTG
AACTTGCGGG CTCGTTCCAT GATCACCACC CACCCGGCCC TGGTGCTGCT CTGGTGTCAG
ATACTGCTGC TTGTCAACCA CACCGACTAC CGCTGGTGGG CAGAAGTGCA GCAGACCCCG
AAAAGACACA GTCTGTCCAG CACAAAGTTA CTTAGTCCCC AGATGTCTGG AGAAGAGGAG
GATTCTGACT TGGCAGCCAA ACTTGGAATG TGCAATAGAG AAATAGTACG AAGAGGGGCT
CTCATTCTCT TCTGTGATTA TGTCTGTCAG AACCTCCATG ACTCCGAGCA CTTAACGTGG
CTCATTGTAA ATCACATTCA AGATCTGATC AGCCTTTCCC ACGAGCCTCC AGTACAGGAC
TTCATCAGTG CCGTTCATCG GAACTCTGCT GCCAGCGGCC TGTTCATCCA GGCAATTCAG
TCTCGTTGTG AAAACCTTTC AACTCCAACC ATGCTGAAGA AAACTCTTCA GTGCTTGGAG
GGGATCCATC TCAGCCAGTC GGGAGCTGTG CTCACGCTGT ATGTGGACAG GCTTCTGTGC
ACCCCTTTCC GTGTGCTGGC TCGCATGGTC GACATCCTTG CTTGTCGCCG GGTAGAAATG
CTTCTGGCTG CAAATTTACA GAGCAGCATG GCCCAGTTGC CAATGGAAGA ACTCAACAGA
ATCCAGGAAT ACCTTCAGAG CAGCGGGCTC GCTCAGAGAC ACCAAAGGCT CTATTCCCTG
CTGGACAGGT TTCGTCTCTC CACCATGCAA GACTCACTTA GTCCCTCTCC TCCAGTCTCT
TCCCACCCGC TGGACGGGGA TGGGCACGTG TCACTGGAAA CAGTGAGTCC GGACAAAGAC
TGGTACGTTC ATCTTGTCAA ATCCCAGTGT TGGACCAGGT CAGATTCTGC ACTGCTGGAA
GGTGCAGAGC TGGTGAATCG GATTCCTGCT GAAGATATGA ATGCCTTCAT GATGAACTCG
GAGTTCAACC TAAGCCTGCT AGCTCCATGC TTAAGCCTAG GGATGAGTGA AATTTCTGGT
GGCCAGAAGA GTGCCCTTTT TGAAGCAGCC CGTGAGGTGA CTCTGGCCCG TGTGAGCGGC
ACCGTGCAGC AGCTCCCTGC TGTCCATCAT GTCTTCCAGC CCGAGCTGCC TGCAGAGCCG
GCGGCCTACT GGAGCAAGTT GAATGATCTG TTTGGGGATG CTGCACTGTA TCAGTCCCTG
CCCACTCTGG CCCGGGCCCT GGCACAGTAC CTGGTGGTGG TCTCCAAACT GCCCAGTCAT
TTGCACCTTC CTCCTGAGAA AGAGAAGGAC ATTGTGAAAT TCGTGGTGGC AACCCTTGAG
GCCCTGTCCT GGCATTTGAT CCATGAGCAG ATCCCGCTGA GTCTGGATCT CCAGGCAGGG
CTGGACTGCT GCTGCCTGGC CCTGCAGCTG CCTGGCCTCT GGAGCGTGGT CTCCTCCACA
GAGTTTGTGA CCCACGCCTG CTCCCTCATC TACTGTGTGC ACTTCATCCT GGAGGCCGTT
GCAGTGCAGC CTGGAGAGCA GCTTCTTAGT CCAGAAAGAA GGACAAATAC CCCAAAAGCC
ATCAGCGAGG AGGAGGAGGA AGTAGATCCA AACACACAGA ATCCTAAGTA TATCACTGCA
GCCTGTGAGA TGGTGGCAGA AATGGTGGAG TCTCTGCAGT CGGTGTTGGC CTTGGGTCAT
AAAAGGAATA GCGGCGTGCC GGCGTTTCTC ACGCCATTGC TAAGGAACAT CATCATCAGC
CTGGCCCGCC TGCCCCTTGT CAACAGCTAC ACACGTGTGC CCCCACTGGT GTGGAAGCTT
GGATGGTCAC CCAAACCGGG AGGGGATTTT GGCACAGCAT TCCCTGAGAT CCCCGTGGAG
TTCCTCCAGG AAAAGGAAGT CTTTAAGGAG TTCATCTACC GCATCAACAC ACTAGGCTGG
ACCAGTCGTA CTCAGTTTGA AGAAACTTGG GCCACCCTCC TTGGTGTCCT GGTGACGCAG
CCCCTCGTGA TGGAGCAGGA GGAGAGCCCA CCAGAAGAAG ACACAGAGAG GACCCAGATC
AACGTCCTGG CCGTGCAGGC CATCACCTCA CTGGTGCTCA GTGCAATGAC TGTGCCTGTG
GCCGGCAACC CAGCTGTAAG CTGCTTGGAG CAGCAGCCCC GGAACAAGCC TCTGAAAGCT
CTCGACACCA GGTTTGGGAG GAAGCTGAGC ATTATCAGAG GGATTGTGGA GCAAGAGATT
CAAGCAATGG TTTCAAAGAG AGAGAATATT GCCACCCATC ATTTATATCA GGCATGGGAT
CCTGTCCCTT CTCTGTCTCC GGCTACTACA GGTGCCCTCA TCAGCCACGA GAAGCTGCTG
CTACAGATCA ACCCCGAGCG GGAGCTGGGG AGCATGAGCT ACAAACTCGG CCAGGTGTCC
ATACACTCCG TGTGGCTGGG GAACAGCATC ACACCCCTGA GGGAGGAGGA ATGGGACGAG
GAAGAGGAGG AGGAGGCCGA CGCCCCTGCA CCTTCGTCAC CACCCACGTC TCCAGTCAAC
TCCAGGAAAC ACCGGGCTGG AGTTGACATC CACTCCTGTT CGCAGTTTTT GCTTGAGTTG
TACAGCCGCT GGATCCTGCC GTCCAGCTCA GCCAGGAGGA CCCCGGCCAT CCTGATCAGT
GAGGTGGTCA GATCCCTTCT AGTGGTCTCA GACTTGTTCA CCGAGCGCAA CCAGTTTGAG
CTGATGTATG TGACGCTGAC AGAACTGCGA AGGGTGCACC CTTCAGAAGA CGAGATCCTC
GCTCAGTACC TGGTGCCTGC CACCTGCAAG GCAGCTGCCG TCCTTGGGAT GGACAAGGCC
GTGGCGGAGC CTGTCAGCCG CCTGCTGGAG AGCACGCTCA GGAGCAGCCA CCTGCCCAGC
AGGGTTGGAG CCCTGCACGG CGTCCTCTAT GTGCTGGAGT GCGACCTGCT GGACGACACT
GCCAAGCAGC TCATCCCGGT CATCAGCGAC TATCTCCTCT CCAACCTGAA AGGGATCGCC
CACTGCGTGA ACATTCACAG CCAGCAGCAC GTACTGGTCA TGTGTGCCAC TGCGTTTTAC
CTCATTGAGA ACTATCCTCT GGACGTAGGG CCGGAATTTT CAGCATCAAT AATACAGATG
TGTGGGGTGA TGCTGTCTGG AAGTGAGGAG TCCACCCCCT CCATCATTTA CCACTGTGCC
CTCAGAGGCC TGGAGCGCCT CCTGCTCTCT GAGCAGCTCT CCCGCCTGGA TGCAGAATCG
CTGGTCAAGC TGAGTGTGGA CAGAGTGAAC GTGCACAGCC CGCACCGGGC CATGGCGGCT
CTGGGCCTGA TGCTCACCTG CATGTACACA GGAAAGGAGA AAGTCAGTCC GGGTAGAACT
TCAGACCCTA ATCCTGCAGC CCCCGACAGC GAGTCAGTGA TTGTTGCTAT GGAGCGGGTA
TCTGTTCTTT TTGATAGGAT CAGGAAAGGC TTTCCTTGTG AAGCCAGAGT GGTGGCCAGG
ATCCTGCCCC AGTTTCTAGA CGACTTCTTC CCACCCCAGG ACATCATGAA CAAAGTCATC
GGAGAGTTTC TGTCCAACCA GCAGCCATAC CCCCAGTTCA TGGCCACCGT GGTGTATAAG
GTGTTTCAGA CTCTGCACAG CACCGGGCAG TCGTCCATGG TCCGGGACTG GGTCATGCTG
TCCCTCTCCA ACTTCACGCA GAGGGCCCCG GTCGCCATGG CCACGTGGAG CCTCTCCTGC
TTCTTTGTCA GCGCGTCCAC CAGCCCGTGG GTCGCGGCGA TCCTCCCACA TGTCATCAGC
AGGATGGGCA AGCTGGAGCA GGTGGACGTG AACCTTTTCT GCCTGGTCGC CACAGACTTC
TACAGACACC AGATAGAGGA GGAGCTCGAC CGCAGGGCCT TCCAGTCTGT GCTTGAGGTG
GTTGCAGCCC CAGGAAGCCC ATATCACCGG CTGCTGACTT GTTTACGAAA TGTCCACAAG
GTCACCACCT GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002102.4
CDS317..9751
Misc Feature(1)172..172(+)
Misc Feature(2)182..182(+)
Misc Feature(3)192..257(+)
Misc Feature(4)323..355(+)
Misc Feature(5)341..343(+)
Misc Feature(6)368..436(+)
Misc Feature(7)848..850(+)
Misc Feature(8)932..1045(+)
Misc Feature(9)1022..1024(+)
Misc Feature(10)1058..1171(+)
Misc Feature(11)1268..1402(+)
Misc Feature(12)1349..1351(+)
Misc Feature(13)1553..1555(+)
Misc Feature(14)1577..1579(+)
Misc Feature(15)1607..1609(+)
Misc Feature(16)1616..1618(+)
Misc Feature(17)1616..1618(+)
Misc Feature(18)1646..1648(+)
Misc Feature(19)1853..1858(+)
Misc Feature(20)1853..1855(+)
Misc Feature(21)1904..1909(+)
Misc Feature(22)1970..1975(+)
Misc Feature(23)1970..1972(+)
Misc Feature(24)2072..2074(+)
Misc Feature(25)2081..2086(+)
Misc Feature(26)2726..2839(+)
Misc Feature(27)3026..3142(+)
Misc Feature(28)3857..3859(+)
Misc Feature(29)3857..3859(+)
Misc Feature(30)3905..3907(+)
Misc Feature(31)3917..3919(+)
Misc Feature(32)3917..3919(+)
Misc Feature(33)4853..4981(+)
Misc Feature(34)5930..5932(+)
Misc Feature(35)5942..5944(+)
Misc Feature(36)6542..6544(+)
Misc Feature(37)7505..7534(+)
Misc Feature(38)8273..8275(+)
Exon (1)1..585
Gene:HTT
Gene Synonym:
Exon (2)586..669
Gene:HTT
Gene Synonym:
Exon (3)670..790
Gene:HTT
Gene Synonym:
Exon (4)791..850
Gene:HTT
Gene Synonym:
Exon (5)851..930
Gene:HTT
Gene Synonym:
Exon (6)931..1069
Gene:HTT
Gene Synonym:
Exon (7)1070..1211
Gene:HTT
Gene Synonym:
Exon (8)1212..1390
Gene:HTT
Gene Synonym:
Exon (9)1391..1595
Gene:HTT
Gene Synonym:
Exon (10)1596..1643
Gene:HTT
Gene Synonym:
Exon (11)1644..1724
Gene:HTT
Gene Synonym:
Exon (12)1725..2065
Gene:HTT
Gene Synonym:
Exon (13)2066..2189
Gene:HTT
Gene Synonym:
Exon (14)2190..2308
Gene:HTT
Gene Synonym:
Exon (15)2309..2420
Gene:HTT
Gene Synonym:
Exon (16)2421..2558
Gene:HTT
Gene Synonym:
Exon (17)2559..2717
Gene:HTT
Gene Synonym:
Exon (18)2718..2815
Gene:HTT
Gene Synonym:
Exon (19)2816..2955
Gene:HTT
Gene Synonym:
Exon (20)2956..3019
Gene:HTT
Gene Synonym:
Exon (21)3020..3120
Gene:HTT
Gene Synonym:
Exon (22)3121..3267
Gene:HTT
Gene Synonym:
Exon (23)3268..3388
Gene:HTT
Gene Synonym:
Exon (24)3389..3465
Gene:HTT
Gene Synonym:
Exon (25)3466..3617
Gene:HTT
Gene Synonym:
Exon (26)3618..3820
Gene:HTT
Gene Synonym:
Exon (27)3821..3947
Gene:HTT
Gene Synonym:
Exon (28)3948..4075
Gene:HTT
Gene Synonym:
Exon (29)4076..4186
Gene:HTT
Gene Synonym:
Exon (30)4187..4264
Gene:HTT
Gene Synonym:
Exon (31)4265..4488
Gene:HTT
Gene Synonym:
Exon (32)4489..4567
Gene:HTT
Gene Synonym:
Exon (33)4568..4729
Gene:HTT
Gene Synonym:
Exon (34)4730..4785
Gene:HTT
Gene Synonym:
Exon (35)4786..4934
Gene:HTT
Gene Synonym:
Exon (36)4935..5071
Gene:HTT
Gene Synonym:
Exon (37)5072..5188
Gene:HTT
Gene Synonym:
Exon (38)5189..5311
Gene:HTT
Gene Synonym:
Exon (39)5312..5547
Gene:HTT
Gene Synonym:
Exon (40)5548..5690
Gene:HTT
Gene Synonym:
Exon (41)5691..5898
Gene:HTT
Gene Synonym:
Exon (42)5899..6040
Gene:HTT
Gene Synonym:
Exon (43)6041..6220
Gene:HTT
Gene Synonym:
Exon (44)6221..6397
Gene:HTT
Gene Synonym:
Exon (45)6398..6474
Gene:HTT
Gene Synonym:
Exon (46)6475..6613
Gene:HTT
Gene Synonym:
Exon (47)6614..6736
Gene:HTT
Gene Synonym:
Exon (48)6737..6950
Gene:HTT
Gene Synonym:
Exon (49)6951..7096
Gene:HTT
Gene Synonym:
Exon (50)7097..7274
Gene:HTT
Gene Synonym:
Exon (51)7275..7376
Gene:HTT
Gene Synonym:
Exon (52)7377..7564
Gene:HTT
Gene Synonym:
Exon (53)7565..7691
Gene:HTT
Gene Synonym:
Exon (54)7692..7792
Gene:HTT
Gene Synonym:
Exon (55)7793..7947
Gene:HTT
Gene Synonym:
Exon (56)7948..8087
Gene:HTT
Gene Synonym:
Exon (57)8088..8170
Gene:HTT
Gene Synonym:
Exon (58)8171..8301
Gene:HTT
Gene Synonym:
Exon (59)8302..8431
Gene:HTT
Gene Synonym:
Exon (60)8432..8587
Gene:HTT
Gene Synonym:
Exon (61)8588..8778
Gene:HTT
Gene Synonym:
Exon (62)8779..8893
Gene:HTT
Gene Synonym:
Exon (63)8894..9107
Gene:HTT
Gene Synonym:
Exon (64)9108..9213
Gene:HTT
Gene Synonym:
Exon (65)9214..9376
Gene:HTT
Gene Synonym:
Exon (66)9377..9537
Gene:HTT
Gene Synonym:
Exon (67)9538..13652
Gene:HTT
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002111
Organism Homo sapiens (human)
Definition Homo sapiens huntingtin (HTT), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002111

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
6841
6901
6961
7021
7081
7141
7201
7261
7321
7381
7441
7501
7561
7621
7681
7741
7801
7861
7921
7981
8041
8101
8161
8221
8281
8341
8401
8461
8521
8581
8641
8701
8761
8821
8881
8941
9001
9061
9121
9181
9241
9301
9361
9421
ATGGCGACCC TGGAAAAGCT GATGAAGGCC TTCGAGTCCC TCAAGTCCTT CCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAACAG
CCGCCACCGC CGCCGCCGCC GCCGCCGCCT CCTCAGCTTC CTCAGCCGCC GCCGCAGGCA
CAGCCGCTGC TGCCTCAGCC GCAGCCGCCC CCGCCGCCGC CCCCGCCGCC ACCCGGCCCG
GCTGTGGCTG AGGAGCCGCT GCACCGACCA AAGAAAGAAC TTTCAGCTAC CAAGAAAGAC
CGTGTGAATC ATTGTCTGAC AATATGTGAA AACATAGTGG CACAGTCTGT CAGAAATTCT
CCAGAATTTC AGAAACTTCT GGGCATCGCT ATGGAACTTT TTCTGCTGTG CAGTGATGAC
GCAGAGTCAG ATGTCAGGAT GGTGGCTGAC GAATGCCTCA ACAAAGTTAT CAAAGCTTTG
ATGGATTCTA ATCTTCCAAG GTTACAGCTC GAGCTCTATA AGGAAATTAA AAAGAATGGT
GCCCCTCGGA GTTTGCGTGC TGCCCTGTGG AGGTTTGCTG AGCTGGCTCA CCTGGTTCGG
CCTCAGAAAT GCAGGCCTTA CCTGGTGAAC CTTCTGCCGT GCCTGACTCG AACAAGCAAG
AGACCCGAAG AATCAGTCCA GGAGACCTTG GCTGCAGCTG TTCCCAAAAT TATGGCTTCT
TTTGGCAATT TTGCAAATGA CAATGAAATT AAGGTTTTGT TAAAGGCCTT CATAGCGAAC
CTGAAGTCAA GCTCCCCCAC CATTCGGCGG ACAGCGGCTG GATCAGCAGT GAGCATCTGC
CAGCACTCAA GAAGGACACA ATATTTCTAT AGTTGGCTAC TAAATGTGCT CTTAGGCTTA
CTCGTTCCTG TCGAGGATGA ACACTCCACT CTGCTGATTC TTGGCGTGCT GCTCACCCTG
AGGTATTTGG TGCCCTTGCT GCAGCAGCAG GTCAAGGACA CAAGCCTGAA AGGCAGCTTC
GGAGTGACAA GGAAAGAAAT GGAAGTCTCT CCTTCTGCAG AGCAGCTTGT CCAGGTTTAT
GAACTGACGT TACATCATAC ACAGCACCAA GACCACAATG TTGTGACCGG AGCCCTGGAG
CTGTTGCAGC AGCTCTTCAG AACGCCTCCA CCCGAGCTTC TGCAAACCCT GACCGCAGTC
GGGGGCATTG GGCAGCTCAC CGCTGCTAAG GAGGAGTCTG GTGGCCGAAG CCGTAGTGGG
AGTATTGTGG AACTTATAGC TGGAGGGGGT TCCTCATGCA GCCCTGTCCT TTCAAGAAAA
CAAAAAGGCA AAGTGCTCTT AGGAGAAGAA GAAGCCTTGG AGGATGACTC TGAATCGAGA
TCGGATGTCA GCAGCTCTGC CTTAACAGCC TCAGTGAAGG ATGAGATCAG TGGAGAGCTG
GCTGCTTCTT CAGGGGTTTC CACTCCAGGG TCAGCAGGTC ATGACATCAT CACAGAACAG
CCACGGTCAC AGCACACACT GCAGGCGGAC TCAGTGGATC TGGCCAGCTG TGACTTGACA
AGCTCTGCCA CTGATGGGGA TGAGGAGGAT ATCTTGAGCC ACAGCTCCAG CCAGGTCAGC
GCCGTCCCAT CTGACCCTGC CATGGACCTG AATGATGGGA CCCAGGCCTC GTCGCCCATC
AGCGACAGCT CCCAGACCAC CACCGAAGGG CCTGATTCAG CTGTTACCCC TTCAGACAGT
TCTGAAATTG TGTTAGACGG TACCGACAAC CAGTATTTGG GCCTGCAGAT TGGACAGCCC
CAGGATGAAG ATGAGGAAGC CACAGGTATT CTTCCTGATG AAGCCTCGGA GGCCTTCAGG
AACTCTTCCA TGGCCCTTCA ACAGGCACAT TTATTGAAAA ACATGAGTCA CTGCAGGCAG
CCTTCTGACA GCAGTGTTGA TAAATTTGTG TTGAGAGATG AAGCTACTGA ACCGGGTGAT
CAAGAAAACA AGCCTTGCCG CATCAAAGGT GACATTGGAC AGTCCACTGA TGATGACTCT
GCACCTCTTG TCCATTGTGT CCGCCTTTTA TCTGCTTCGT TTTTGCTAAC AGGGGGAAAA
AATGTGCTGG TTCCGGACAG GGATGTGAGG GTCAGCGTGA AGGCCCTGGC CCTCAGCTGT
GTGGGAGCAG CTGTGGCCCT CCACCCGGAA TCTTTCTTCA GCAAACTCTA TAAAGTTCCT
CTTGACACCA CGGAATACCC TGAGGAACAG TATGTCTCAG ACATCTTGAA CTACATCGAT
CATGGAGACC CACAGGTTCG AGGAGCCACT GCCATTCTCT GTGGGACCCT CATCTGCTCC
ATCCTCAGCA GGTCCCGCTT CCACGTGGGA GATTGGATGG GCACCATTAG AACCCTCACA
GGAAATACAT TTTCTTTGGC GGATTGCATT CCTTTGCTGC GGAAAACACT GAAGGATGAG
TCTTCTGTTA CTTGCAAGTT AGCTTGTACA GCTGTGAGGA ACTGTGTCAT GAGTCTCTGC
AGCAGCAGCT ACAGTGAGTT AGGACTGCAG CTGATCATCG ATGTGCTGAC TCTGAGGAAC
AGTTCCTATT GGCTGGTGAG GACAGAGCTT CTGGAAACCC TTGCAGAGAT TGACTTCAGG
CTGGTGAGCT TTTTGGAGGC AAAAGCAGAA AACTTACACA GAGGGGCTCA TCATTATACA
GGGCTTTTAA AACTGCAAGA ACGAGTGCTC AATAATGTTG TCATCCATTT GCTTGGAGAT
GAAGACCCCA GGGTGCGACA TGTTGCCGCA GCATCACTAA TTAGGCTTGT CCCAAAGCTG
TTTTATAAAT GTGACCAAGG ACAAGCTGAT CCAGTAGTGG CCGTGGCAAG AGATCAAAGC
AGTGTTTACC TGAAACTTCT CATGCATGAG ACGCAGCCTC CATCTCATTT CTCCGTCAGC
ACAATAACCA GAATATATAG AGGCTATAAC CTACTACCAA GCATAACAGA CGTCACTATG
GAAAATAACC TTTCAAGAGT TATTGCAGCA GTTTCTCATG AACTAATCAC ATCAACCACC
AGAGCACTCA CATTTGGATG CTGTGAAGCT TTGTGTCTTC TTTCCACTGC CTTCCCAGTT
TGCATTTGGA GTTTAGGTTG GCACTGTGGA GTGCCTCCAC TGAGTGCCTC AGATGAGTCT
AGGAAGAGCT GTACCGTTGG GATGGCCACA ATGATTCTGA CCCTGCTCTC GTCAGCTTGG
TTCCCATTGG ATCTCTCAGC CCATCAAGAT GCTTTGATTT TGGCCGGAAA CTTGCTTGCA
GCCAGTGCTC CCAAATCTCT GAGAAGTTCA TGGGCCTCTG AAGAAGAAGC CAACCCAGCA
GCCACCAAGC AAGAGGAGGT CTGGCCAGCC CTGGGGGACC GGGCCCTGGT GCCCATGGTG
GAGCAGCTCT TCTCTCACCT GCTGAAGGTG ATTAACATTT GTGCCCACGT CCTGGATGAC
GTGGCTCCTG GACCCGCAAT AAAGGCAGCC TTGCCTTCTC TAACAAACCC CCCTTCTCTA
AGTCCCATCC GACGAAAGGG GAAGGAGAAA GAACCAGGAG AACAAGCATC TGTACCGTTG
AGTCCCAAGA AAGGCAGTGA GGCCAGTGCA GCTTCTAGAC AATCTGATAC CTCAGGTCCT
GTTACAACAA GTAAATCCTC ATCACTGGGG AGTTTCTATC ATCTTCCTTC ATACCTCAAA
CTGCATGATG TCCTGAAAGC TACACACGCT AACTACAAGG TCACGCTGGA TCTTCAGAAC
AGCACGGAAA AGTTTGGAGG GTTTCTCCGC TCAGCCTTGG ATGTTCTTTC TCAGATACTA
GAGCTGGCCA CACTGCAGGA CATTGGGAAG TGTGTTGAAG AGATCCTAGG ATACCTGAAA
TCCTGCTTTA GTCGAGAACC AATGATGGCA ACTGTTTGTG TTCAACAATT GTTGAAGACT
CTCTTTGGCA CAAACTTGGC CTCCCAGTTT GATGGCTTAT CTTCCAACCC CAGCAAGTCA
CAAGGCCGAG CACAGCGCCT TGGCTCCTCC AGTGTGAGGC CAGGCTTGTA CCACTACTGC
TTCATGGCCC CGTACACCCA CTTCACCCAG GCCCTCGCTG ACGCCAGCCT GAGGAACATG
GTGCAGGCGG AGCAGGAGAA CGACACCTCG GGATGGTTTG ATGTCCTCCA GAAAGTGTCT
ACCCAGTTGA AGACAAACCT CACGAGTGTC ACAAAGAACC GTGCAGATAA GAATGCTATT
CATAATCACA TTCGTTTGTT TGAACCTCTT GTTATAAAAG CTTTAAAACA GTACACGACT
ACAACATGTG TGCAGTTACA GAAGCAGGTT TTAGATTTGC TGGCGCAGCT GGTTCAGTTA
CGGGTTAATT ACTGTCTTCT GGATTCAGAT CAGGTGTTTA TTGGCTTTGT ATTGAAACAG
TTTGAATACA TTGAAGTGGG CCAGTTCAGG GAATCAGAGG CAATCATTCC AAACATCTTT
TTCTTCTTGG TATTACTATC TTATGAACGC TATCATTCAA AACAGATCAT TGGAATTCCT
AAAATCATTC AGCTCTGTGA TGGCATCATG GCCAGTGGAA GGAAGGCTGT GACACATGCC
ATACCGGCTC TGCAGCCCAT AGTCCACGAC CTCTTTGTAT TAAGAGGAAC AAATAAAGCT
GATGCAGGAA AAGAGCTTGA AACCCAAAAA GAGGTGGTGG TGTCAATGTT ACTGAGACTC
ATCCAGTACC ATCAGGTGTT GGAGATGTTC ATTCTTGTCC TGCAGCAGTG CCACAAGGAG
AATGAAGACA AGTGGAAGCG ACTGTCTCGA CAGATAGCTG ACATCATCCT CCCAATGTTA
GCCAAACAGC AGATGCACAT TGACTCTCAT GAAGCCCTTG GAGTGTTAAA TACATTATTT
GAGATTTTGG CCCCTTCCTC CCTCCGTCCG GTAGACATGC TTTTACGGAG TATGTTCGTC
ACTCCAAACA CAATGGCGTC CGTGAGCACT GTTCAACTGT GGATATCGGG AATTCTGGCC
ATTTTGAGGG TTCTGATTTC CCAGTCAACT GAAGATATTG TTCTTTCTCG TATTCAGGAG
CTCTCCTTCT CTCCGTATTT AATCTCCTGT ACAGTAATTA ATAGGTTAAG AGATGGGGAC
AGTACTTCAA CGCTAGAAGA ACACAGTGAA GGGAAACAAA TAAAGAATTT GCCAGAAGAA
ACATTTTCAA GGTTTCTATT ACAACTGGTT GGTATTCTTT TAGAAGACAT TGTTACAAAA
CAGCTGAAGG TGGAAATGAG TGAGCAGCAA CATACTTTCT ATTGCCAGGA ACTAGGCACA
CTGCTAATGT GTCTGATCCA CATCTTCAAG TCTGGAATGT TCCGGAGAAT CACAGCAGCT
GCCACTAGGC TGTTCCGCAG TGATGGCTGT GGCGGCAGTT TCTACACCCT GGACAGCTTG
AACTTGCGGG CTCGTTCCAT GATCACCACC CACCCGGCCC TGGTGCTGCT CTGGTGTCAG
ATACTGCTGC TTGTCAACCA CACCGACTAC CGCTGGTGGG CAGAAGTGCA GCAGACCCCG
AAAAGACACA GTCTGTCCAG CACAAAGTTA CTTAGTCCCC AGATGTCTGG AGAAGAGGAG
GATTCTGACT TGGCAGCCAA ACTTGGAATG TGCAATAGAG AAATAGTACG AAGAGGGGCT
CTCATTCTCT TCTGTGATTA TGTCTGTCAG AACCTCCATG ACTCCGAGCA CTTAACGTGG
CTCATTGTAA ATCACATTCA AGATCTGATC AGCCTTTCCC ACGAGCCTCC AGTACAGGAC
TTCATCAGTG CCGTTCATCG GAACTCTGCT GCCAGCGGCC TGTTCATCCA GGCAATTCAG
TCTCGTTGTG AAAACCTTTC AACTCCAACC ATGCTGAAGA AAACTCTTCA GTGCTTGGAG
GGGATCCATC TCAGCCAGTC GGGAGCTGTG CTCACGCTGT ATGTGGACAG GCTTCTGTGC
ACCCCTTTCC GTGTGCTGGC TCGCATGGTC GACATCCTTG CTTGTCGCCG GGTAGAAATG
CTTCTGGCTG CAAATTTACA GAGCAGCATG GCCCAGTTGC CAATGGAAGA ACTCAACAGA
ATCCAGGAAT ACCTTCAGAG CAGCGGGCTC GCTCAGAGAC ACCAAAGGCT CTATTCCCTG
CTGGACAGGT TTCGTCTCTC CACCATGCAA GACTCACTTA GTCCCTCTCC TCCAGTCTCT
TCCCACCCGC TGGACGGGGA TGGGCACGTG TCACTGGAAA CAGTGAGTCC GGACAAAGAC
TGGTACGTTC ATCTTGTCAA ATCCCAGTGT TGGACCAGGT CAGATTCTGC ACTGCTGGAA
GGTGCAGAGC TGGTGAATCG GATTCCTGCT GAAGATATGA ATGCCTTCAT GATGAACTCG
GAGTTCAACC TAAGCCTGCT AGCTCCATGC TTAAGCCTAG GGATGAGTGA AATTTCTGGT
GGCCAGAAGA GTGCCCTTTT TGAAGCAGCC CGTGAGGTGA CTCTGGCCCG TGTGAGCGGC
ACCGTGCAGC AGCTCCCTGC TGTCCATCAT GTCTTCCAGC CCGAGCTGCC TGCAGAGCCG
GCGGCCTACT GGAGCAAGTT GAATGATCTG TTTGGGGATG CTGCACTGTA TCAGTCCCTG
CCCACTCTGG CCCGGGCCCT GGCACAGTAC CTGGTGGTGG TCTCCAAACT GCCCAGTCAT
TTGCACCTTC CTCCTGAGAA AGAGAAGGAC ATTGTGAAAT TCGTGGTGGC AACCCTTGAG
GCCCTGTCCT GGCATTTGAT CCATGAGCAG ATCCCGCTGA GTCTGGATCT CCAGGCAGGG
CTGGACTGCT GCTGCCTGGC CCTGCAGCTG CCTGGCCTCT GGAGCGTGGT CTCCTCCACA
GAGTTTGTGA CCCACGCCTG CTCCCTCATC TACTGTGTGC ACTTCATCCT GGAGGCCGTT
GCAGTGCAGC CTGGAGAGCA GCTTCTTAGT CCAGAAAGAA GGACAAATAC CCCAAAAGCC
ATCAGCGAGG AGGAGGAGGA AGTAGATCCA AACACACAGA ATCCTAAGTA TATCACTGCA
GCCTGTGAGA TGGTGGCAGA AATGGTGGAG TCTCTGCAGT CGGTGTTGGC CTTGGGTCAT
AAAAGGAATA GCGGCGTGCC GGCGTTTCTC ACGCCATTGC TAAGGAACAT CATCATCAGC
CTGGCCCGCC TGCCCCTTGT CAACAGCTAC ACACGTGTGC CCCCACTGGT GTGGAAGCTT
GGATGGTCAC CCAAACCGGG AGGGGATTTT GGCACAGCAT TCCCTGAGAT CCCCGTGGAG
TTCCTCCAGG AAAAGGAAGT CTTTAAGGAG TTCATCTACC GCATCAACAC ACTAGGCTGG
ACCAGTCGTA CTCAGTTTGA AGAAACTTGG GCCACCCTCC TTGGTGTCCT GGTGACGCAG
CCCCTCGTGA TGGAGCAGGA GGAGAGCCCA CCAGAAGAAG ACACAGAGAG GACCCAGATC
AACGTCCTGG CCGTGCAGGC CATCACCTCA CTGGTGCTCA GTGCAATGAC TGTGCCTGTG
GCCGGCAACC CAGCTGTAAG CTGCTTGGAG CAGCAGCCCC GGAACAAGCC TCTGAAAGCT
CTCGACACCA GGTTTGGGAG GAAGCTGAGC ATTATCAGAG GGATTGTGGA GCAAGAGATT
CAAGCAATGG TTTCAAAGAG AGAGAATATT GCCACCCATC ATTTATATCA GGCATGGGAT
CCTGTCCCTT CTCTGTCTCC GGCTACTACA GGTGCCCTCA TCAGCCACGA GAAGCTGCTG
CTACAGATCA ACCCCGAGCG GGAGCTGGGG AGCATGAGCT ACAAACTCGG CCAGGTGTCC
ATACACTCCG TGTGGCTGGG GAACAGCATC ACACCCCTGA GGGAGGAGGA ATGGGACGAG
GAAGAGGAGG AGGAGGCCGA CGCCCCTGCA CCTTCGTCAC CACCCACGTC TCCAGTCAAC
TCCAGGAAAC ACCGGGCTGG AGTTGACATC CACTCCTGTT CGCAGTTTTT GCTTGAGTTG
TACAGCCGCT GGATCCTGCC GTCCAGCTCA GCCAGGAGGA CCCCGGCCAT CCTGATCAGT
GAGGTGGTCA GATCCCTTCT AGTGGTCTCA GACTTGTTCA CCGAGCGCAA CCAGTTTGAG
CTGATGTATG TGACGCTGAC AGAACTGCGA AGGGTGCACC CTTCAGAAGA CGAGATCCTC
GCTCAGTACC TGGTGCCTGC CACCTGCAAG GCAGCTGCCG TCCTTGGGAT GGACAAGGCC
GTGGCGGAGC CTGTCAGCCG CCTGCTGGAG AGCACGCTCA GGAGCAGCCA CCTGCCCAGC
AGGGTTGGAG CCCTGCACGG CGTCCTCTAT GTGCTGGAGT GCGACCTGCT GGACGACACT
GCCAAGCAGC TCATCCCGGT CATCAGCGAC TATCTCCTCT CCAACCTGAA AGGGATCGCC
CACTGCGTGA ACATTCACAG CCAGCAGCAC GTACTGGTCA TGTGTGCCAC TGCGTTTTAC
CTCATTGAGA ACTATCCTCT GGACGTAGGG CCGGAATTTT CAGCATCAAT AATACAGATG
TGTGGGGTGA TGCTGTCTGG AAGTGAGGAG TCCACCCCCT CCATCATTTA CCACTGTGCC
CTCAGAGGCC TGGAGCGCCT CCTGCTCTCT GAGCAGCTCT CCCGCCTGGA TGCAGAATCG
CTGGTCAAGC TGAGTGTGGA CAGAGTGAAC GTGCACAGCC CGCACCGGGC CATGGCGGCT
CTGGGCCTGA TGCTCACCTG CATGTACACA GGAAAGGAGA AAGTCAGTCC GGGTAGAACT
TCAGACCCTA ATCCTGCAGC CCCCGACAGC GAGTCAGTGA TTGTTGCTAT GGAGCGGGTA
TCTGTTCTTT TTGATAGGAT CAGGAAAGGC TTTCCTTGTG AAGCCAGAGT GGTGGCCAGG
ATCCTGCCCC AGTTTCTAGA CGACTTCTTC CCACCCCAGG ACATCATGAA CAAAGTCATC
GGAGAGTTTC TGTCCAACCA GCAGCCATAC CCCCAGTTCA TGGCCACCGT GGTGTATAAG
GTGTTTCAGA CTCTGCACAG CACCGGGCAG TCGTCCATGG TCCGGGACTG GGTCATGCTG
TCCCTCTCCA ACTTCACGCA GAGGGCCCCG GTCGCCATGG CCACGTGGAG CCTCTCCTGC
TTCTTTGTCA GCGCGTCCAC CAGCCCGTGG GTCGCGGCGA TCCTCCCACA TGTCATCAGC
AGGATGGGCA AGCTGGAGCA GGTGGACGTG AACCTTTTCT GCCTGGTCGC CACAGACTTC
TACAGACACC AGATAGAGGA GGAGCTCGAC CGCAGGGCCT TCCAGTCTGT GCTTGAGGTG
GTTGCAGCCC CAGGAAGCCC ATATCACCGG CTGCTGACTT GTTTACGAAA TGTCCACAAG
GTCACCACCT GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1
Proc. Natl. Acad. Sci. U.S.A. 111 (33), 12085-12090 (2014)
Kayatekin C, Matlack KE, Hesse WR, Guan Y, Chakrabortee S, Russ J, Wanker EE, Shah JV and Lindquist S.


book

Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons
Nat. Neurosci. 17 (8), 1064-1072 (2014)
Pecho-Vrieseling E, Rieker C, Fuchs S, Bleckmann D, Esposito MS, Botta P, Goldstein C, Bernhard M, Galimberti I, Muller M, Luthi A, Arber S, Bouwmeester T, van der Putten H and Di Giorgio FP.


book

Inhibition of mitochondrial protein import by mutant huntingtin
Nat. Neurosci. 17 (6), 822-831 (2014)
Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH and Friedlander RM.


book

Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain
J Huntingtons Dis 2 (4), 491-500 (2013)
Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD and Aronin N.


book

An upstream open reading frame impedes translation of the huntingtin gene
Nucleic Acids Res. 30 (23), 5110-5119 (2002)
Lee J, Park EH, Couture G, Harvey I, Garneau P and Pelletier J.


book

A huntingtin-associated protein enriched in brain with implications for pathology
Nature 378 (6555), 398-402 (1995)
Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH and Ross CA.


book

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8710-8714 (1995)
Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ and Hersch SM.


book

Huntington Disease
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Warby,S.C., Graham,R.K. and Hayden,M.R.


book

Dystonia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Klein,C., Marras,C. and Munchau,A.


book

The Huntington's disease candidate region exhibits many different haplotypes
Nat. Genet. 1 (2), 99-103 (1992)
MacDonald ME, Novelletto A, Lin C, Tagle D, Barnes G, Bates G, Taylor S, Allitto B, Altherr M and Myers R.


 
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