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HEXA hexosaminidase A (alpha polypeptide) [Homo sapiens (human)]

Gene Symbol HEXA
Entrez Gene ID 3073
Full Name hexosaminidase A (alpha polypeptide)
Synonyms TSD
General protein information
Preferred Names
beta-hexosaminidase subunit alpha
Names
beta-hexosaminidase subunit alpha
hexosaminidase subunit A
beta-N-acetylhexosaminidase subunit alpha
N-acetyl-beta-glucosaminidase subunit alpha
NP_000511.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q24.1

Summary This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009]. lac of sum
Disorder MIM:

606869

Disorder Html: Tay-Sachs disease, 272800 (3); GM2-gangliosidosis, several forms,
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu18820 NM_000520 Homo sapiens hexosaminidase A (alpha polypeptide) (HEXA), mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu18820D
Sequence Information ORF Nucleotide Sequence (Length: 1590bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product beta-hexosaminidase subunit alpha preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC356933.1, BC018927.2 and AC009690.17. This sequence is a reference standard in the RefSeqGene project. On May 30, 2008 this sequence version replaced gi:119395761. Summary: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M13520.1, CR627386.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGACAAGCT CCAGGCTTTG GTTTTCGCTG CTGCTGGCGG CAGCGTTCGC AGGACGGGCG 
ACGGCCCTCT GGCCCTGGCC TCAGAACTTC CAAACCTCCG ACCAGCGCTA CGTCCTTTAC
CCGAACAACT TTCAATTCCA GTACGATGTC AGCTCGGCCG CGCAGCCCGG CTGCTCAGTC
CTCGACGAGG CCTTCCAGCG CTATCGTGAC CTGCTTTTCG GTTCCGGGTC TTGGCCCCGT
CCTTACCTCA CAGGGAAACG GCATACACTG GAGAAGAATG TGTTGGTTGT CTCTGTAGTC
ACACCTGGAT GTAACCAGCT TCCTACTTTG GAGTCAGTGG AGAATTATAC CCTGACCATA
AATGATGACC AGTGTTTACT CCTCTCTGAG ACTGTCTGGG GAGCTCTCCG AGGTCTGGAG
ACTTTTAGCC AGCTTGTTTG GAAATCTGCT GAGGGCACAT TCTTTATCAA CAAGACTGAG
ATTGAGGACT TTCCCCGCTT TCCTCACCGG GGCTTGCTGT TGGATACATC TCGCCATTAC
CTGCCACTCT CTAGCATCCT GGACACTCTG GATGTCATGG CGTACAATAA ATTGAACGTG
TTCCACTGGC ATCTGGTAGA TGATCCTTCC TTCCCATATG AGAGCTTCAC TTTTCCAGAG
CTCATGAGAA AGGGGTCCTA CAACCCTGTC ACCCACATCT ACACAGCACA GGATGTGAAG
GAGGTCATTG AATACGCACG GCTCCGGGGT ATCCGTGTGC TTGCAGAGTT TGACACTCCT
GGCCACACTT TGTCCTGGGG ACCAGGTATC CCTGGATTAC TGACTCCTTG CTACTCTGGG
TCTGAGCCCT CTGGCACCTT TGGACCAGTG AATCCCAGTC TCAATAATAC CTATGAGTTC
ATGAGCACAT TCTTCTTAGA AGTCAGCTCT GTCTTCCCAG ATTTTTATCT TCATCTTGGA
GGAGATGAGG TTGATTTCAC CTGCTGGAAG TCCAACCCAG AGATCCAGGA CTTTATGAGG
AAGAAAGGCT TCGGTGAGGA CTTCAAGCAG CTGGAGTCCT TCTACATCCA GACGCTGCTG
GACATCGTCT CTTCTTATGG CAAGGGCTAT GTGGTGTGGC AGGAGGTGTT TGATAATAAA
GTAAAGATTC AGCCAGACAC AATCATACAG GTGTGGCGAG AGGATATTCC AGTGAACTAT
ATGAAGGAGC TGGAACTGGT CACCAAGGCC GGCTTCCGGG CCCTTCTCTC TGCCCCCTGG
TACCTGAACC GTATATCCTA TGGCCCTGAC TGGAAGGATT TCTACATAGT GGAACCCCTG
GCATTTGAAG GTACCCCTGA GCAGAAGGCT CTGGTGATTG GTGGAGAGGC TTGTATGTGG
GGAGAATATG TGGACAACAC AAACCTGGTC CCCAGGCTCT GGCCCAGAGC AGGGGCTGTT
GCCGAAAGGC TGTGGAGCAA CAAGTTGACA TCTGACCTGA CATTTGCCTA TGAACGTTTG
TCACACTTCC GCTGTGAATT GCTGAGGCGA GGTGTCCAGG CCCAACCCCT CAATGTAGGC
TTCTGTGAGC AGGAGTTTGA ACAGACCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000511.2
CDS208..1797
Misc Feature(1)121..123(+)
Misc Feature(2)274..642(+)
Misc Feature(3)706..1740(+)
Misc Feature(4)739..1593(+)
Misc Feature(5)1474..1479(+)
Exon (1)1..460
Gene:HEXA
Gene Synonym:
Exon (2)461..553
Gene:HEXA
Gene Synonym:
Exon (3)554..619
Gene:HEXA
Gene Synonym:
Exon (4)620..666
Gene:HEXA
Gene Synonym:
Exon (5)667..777
Gene:HEXA
Gene Synonym:
Exon (6)778..879
Gene:HEXA
Gene Synonym:
Exon (7)880..1012
Gene:HEXA
Gene Synonym:
Exon (8)1013..1193
Gene:HEXA
Gene Synonym:
Exon (9)1194..1280
Gene:HEXA
Gene Synonym:
Exon (10)1281..1353
Gene:HEXA
Gene Synonym:
Exon (11)1354..1537
Gene:HEXA
Gene Synonym:
Exon (12)1538..1628
Gene:HEXA
Gene Synonym:
Exon (13)1629..1733
Gene:HEXA
Gene Synonym:
Exon (14)1734..2437
Gene:HEXA
Gene Synonym:
Translation
Position Chain Variation Link
5 5 c, g dbSNP:553454133
24 24 c, g dbSNP:538205976
41 41 a, g dbSNP:77707876
47 47 a, g dbSNP:558965607
68 68 a, g dbSNP:537784407
72 72 a, g dbSNP:561320483
82 82 c, g dbSNP:373306215
83 83 c, t dbSNP:548737963
140 140 c, g, t dbSNP:530323079
145 145 c, g dbSNP:566140471
149 149 a, g dbSNP:147174351
150 150 c, t dbSNP:755843421
157 157 a, g dbSNP:760641793
159 159 c, t dbSNP:143551545
162 162 g, t dbSNP:779029124
164 164 a, g dbSNP:772981154
170 170 a, c dbSNP:370312523
175 175 c, g dbSNP:761538590
176 176 a, c, t dbSNP:768292244
178 178 c, g dbSNP:748806533
180 180 c, t dbSNP:775040628
182 182 c, t dbSNP:771384167
187 187 g, t dbSNP:747583524
191 191 c, g, t dbSNP:758847344
192 192 a, g dbSNP:199585195
196 196 c, g dbSNP:779349017
199 199 c, t dbSNP:755241190
201 201 -, gcgggcca dbSNP:759154405
202 202 c, t dbSNP:753916320
204 204 a, g dbSNP:766510036
208 208 a, c, g dbSNP:121907965
209 209 c, t dbSNP:786204721
215 215 a, c, g dbSNP:374524755
216 216 c, t dbSNP:1800428
217 217 c, t dbSNP:146938346
218 218 c, t dbSNP:762634101
219 219 c, t dbSNP:774967373
227 227 a, g dbSNP:751546658
233 233 c, g dbSNP:769370282
239 239 c, t dbSNP:141120074
245 245 c, t dbSNP:145666272
255 255 c, t dbSNP:772706192
259 259 c, g dbSNP:748584487
260 260 a, g dbSNP:371133961
263 263 c, g dbSNP:755197781
266 266 c, t dbSNP:749545037
269 269 c, t dbSNP:780078337
271 271 a, g dbSNP:756218457
272 272 c, t dbSNP:750498339
274 274 c, t dbSNP:767500499
276 276 c, g dbSNP:143554538
285 285 a, g dbSNP:121907964
289 289 c, t dbSNP:751393950
292 292 a, g dbSNP:763909810
298 298 c, g dbSNP:556872918
309 309 c, t dbSNP:377310315
311 311 a, c dbSNP:140868947
312 312 a, g dbSNP:542366960
316 316 a, t dbSNP:759157781
320 320 a, t dbSNP:776271078
323 323 g, t dbSNP:121907979
325 325 c, t dbSNP:772757495
327 327 c, t dbSNP:762382202
328 328 c, g dbSNP:774947508
330 330 a, g dbSNP:769075910
341 341 a, c dbSNP:144089645
342 342 a, c, g dbSNP:375574405
346 346 c, t dbSNP:745996955
347 347 -, a dbSNP:773982691
355 355 c, g, t dbSNP:757285705
367 367 g, t dbSNP:751522577
375 375 c, t dbSNP:777515618
380 380 a, g, t dbSNP:387906949
383 383 c, t dbSNP:146577256
393 393 c, t dbSNP:765001944
394 394 a, g dbSNP:759092928
404 404 a, g dbSNP:753442808
408 408 a, c dbSNP:766020311
409 409 g, t dbSNP:760202948
418 418 c, t dbSNP:775000497
440 440 a, g dbSNP:769035623
444 444 c, t dbSNP:763428989
448 448 c, g dbSNP:144231599
457 457 a, g dbSNP:775695266
466 466 c, t dbSNP:573269641
467 467 a, g dbSNP:766966378
478 478 a, g dbSNP:756740656
479 479 a, t dbSNP:753159773
492 492 c, g dbSNP:765667778
498 498 c, g, t dbSNP:776967919
504 504 a, c dbSNP:766640260
519 519 g, t dbSNP:760781092
523 523 c, t dbSNP:773446161
525 525 c, g dbSNP:772070778
534 534 c, t dbSNP:11551324
547 547 c, g dbSNP:748190164
552 552 g, t dbSNP:774220090
568 568 a, g dbSNP:774546637
574 574 a, g dbSNP:768750119
587 587 g, t dbSNP:121907975
600 600 g, t dbSNP:763015329
616 616 c, t dbSNP:121907962
617 617 a, g dbSNP:769724246
629 629 c, t dbSNP:754367847
647 647 c, g dbSNP:780484989
662 662 g, t dbSNP:375727994
663 663 c, t dbSNP:750784687
665 665 c, t dbSNP:767677756
671 671 g, t dbSNP:758618617
679 679 a, g dbSNP:752813753
689 689 c, t dbSNP:765136263
703 703 c, t dbSNP:759487463
704 704 a, g dbSNP:398123442
715 715 c, t dbSNP:121907972
716 716 a, g dbSNP:121907957
717 717 c, g dbSNP:760406474
724 724 c, t dbSNP:200743199
726 726 a, g dbSNP:771696420
738 738 g, t dbSNP:747703708
739 739 c, t dbSNP:121907953
740 740 a, c, g, t dbSNP:28941770
741 741 c, t dbSNP:75174831
742 742 c, t dbSNP:781493030
743 743 a, c, t dbSNP:747372270
745 745 c, t dbSNP:28941771
746 746 a, c dbSNP:200513831
747 747 c, g, t dbSNP:121907969
752 752 c, t dbSNP:148511084
755 755 a, t dbSNP:185797496
765 765 c, t dbSNP:144652159
771 771 c, t dbSNP:754966985
773 773 c, g dbSNP:753831831
781 781 c, g dbSNP:387906310
784 784 a, g dbSNP:748427632
788 788 c, t dbSNP:778947516
789 789 a, c, g dbSNP:112614306
794 794 a, g dbSNP:753862880
797 797 a, c dbSNP:121907973
804 804 c, t dbSNP:756010672
805 805 a, g dbSNP:1800429
808 808 c, t dbSNP:770313582
810 810 c, g dbSNP:767318868
812 812 a, g dbSNP:761536872
818 818 a, g dbSNP:121907976
823 823 a, g dbSNP:543071358
828 828 c, t dbSNP:763649208
834 834 g, t dbSNP:762581234
836 836 c, t dbSNP:121907961
839 839 c, t dbSNP:121907974
843 843 a, g dbSNP:774842392
849 849 c, g dbSNP:139948663
857 857 c, t dbSNP:761297135
858 858 g, t dbSNP:773807075
864 864 a, g dbSNP:772581459
871 871 a, c, g, t dbSNP:768751360
875 875 a, g dbSNP:749422284
879 879 a, g dbSNP:780134593
884 884 c, t dbSNP:769866128
899 899 c, t dbSNP:745941151
912 912 a, g dbSNP:781164103
913 913 a, g dbSNP:757119445
916 916 c, t dbSNP:150675340
919 919 a, g dbSNP:746861846
925 925 -, t dbSNP:587779407
926 926 -, a dbSNP:747291156
942 942 c, t dbSNP:777460475
943 943 a, g dbSNP:758166013
946 946 c, t dbSNP:121907970
948 948 a, g dbSNP:76873846
952 952 c, t dbSNP:138058578
954 954 a, g dbSNP:77405894
956 956 a, g, t dbSNP:121907959
961 961 c, t dbSNP:566580738
962 962 a, g dbSNP:762255098
964 964 g, t dbSNP:774868739
966 966 a, g dbSNP:117513345
970 970 a, g, t dbSNP:533004263
971 971 c, g dbSNP:370576428
979 979 c, g dbSNP:121907971
982 982 a, g dbSNP:745997044
983 983 a, c dbSNP:776660720
998 998 c, t dbSNP:771004345
1002 1002 c, t dbSNP:746942625
1012 1012 a, g dbSNP:121907954
1033 1033 c, t dbSNP:773093433
1040 1040 a, t dbSNP:772036483
1043 1043 c, g dbSNP:148199798
1047 1047 a, g dbSNP:778823870
1062 1062 c, t dbSNP:768518776
1065 1065 c, t dbSNP:748958444
1078 1078 a, c dbSNP:779688204
1083 1083 c, t dbSNP:143009489
1085 1085 g, t dbSNP:1054374
1091 1091 a, g dbSNP:199578185
1095 1095 c, t dbSNP:752260651
1103 1103 a, c dbSNP:778191188
1108 1108 a, c dbSNP:758871181
1109 1109 g, t dbSNP:121907977
1113 1113 c, t dbSNP:765612435
1114 1114 a, t dbSNP:759837903
1116 1116 -, a dbSNP:758406312
1117 1117 -, ttc dbSNP:121907960
1122 1122 -, ctt dbSNP:778155650
1136 1136 -, ct dbSNP:751248523
1153 1153 c, t dbSNP:754013071
1154 1154 -, a dbSNP:786204515
1160 1160 a, t dbSNP:766622566
1164 1164 c, t dbSNP:373799508
1168 1168 a, g dbSNP:556877212
1171 1171 g, t dbSNP:772180415
1179 1179 a, c, t dbSNP:28942072
1184 1184 -, t dbSNP:756040251
1190 1190 a, g dbSNP:761861041
1194 1194 a, g dbSNP:121907967
1196 1196 a, g dbSNP:750575614
1208 1208 a, g dbSNP:767713828
1221 1221 c, t dbSNP:149121118
1235 1235 c, g, t dbSNP:191330716
1239 1239 c, t dbSNP:762704131
1240 1240 a, g dbSNP:775322979
1246 1246 a, g, t dbSNP:745555933
1249 1249 g, t dbSNP:574497871
1253 1253 a, g dbSNP:770433168
1254 1254 a, g dbSNP:746518979
1276 1276 c, t dbSNP:779456035
1280 1280 c, t dbSNP:552505619
1291 1291 a, g dbSNP:771447407
1293 1293 c, t dbSNP:749828204
1294 1294 a, g, t dbSNP:557550173
1295 1295 a, t dbSNP:746202567
1298 1298 c, g dbSNP:781611898
1299 1299 c, t dbSNP:757519934
1302 1302 a, t dbSNP:368349228
1307 1307 a, g dbSNP:751790384
1310 1310 a, g dbSNP:764291005
1311 1311 a, g dbSNP:535530869
1313 1313 -, gg dbSNP:774076315
1314 1314 c, t dbSNP:140337137
1318 1318 a, g dbSNP:765082947
1321 1321 g, t dbSNP:759434633
1323 1323 a, g dbSNP:753609749
1330 1330 -, g dbSNP:766138785
1331 1331 a, g dbSNP:199954138
1334 1334 g, t dbSNP:78532913
1336 1336 g, t dbSNP:760355218
1339 1339 g, t dbSNP:772807186
1340 1340 a, g, t dbSNP:761220941
1342 1342 a, g dbSNP:776119987
1343 1343 a, g dbSNP:770176144
1349 1349 a, t dbSNP:746272701
1350 1350 a, g dbSNP:781712951
1361 1361 a, c dbSNP:768164612
1371 1371 c, g dbSNP:760153692
1372 1372 a, g dbSNP:777212186
1373 1373 c, t dbSNP:146714642
1375 1375 -, c dbSNP:772879726
1380 1380 a, c, g dbSNP:575836910
1383 1383 a, g dbSNP:267606862
1384 1384 c, t dbSNP:121907963
1385 1385 a, g dbSNP:370266293
1389 1389 a, g dbSNP:777737367
1390 1390 -, g dbSNP:770303210
1396 1396 a, c, t dbSNP:778878211
1399 1399 g, t dbSNP:755007226
1402 1402 a, g dbSNP:1800430
1403 1403 a, g, t dbSNP:755973971
1423 1423 c, t dbSNP:140482769
1433 1433 a, g dbSNP:752583618
1436 1436 c, t dbSNP:151251788
1437 1437 c, t dbSNP:751185874
1438 1438 a, g dbSNP:575121167
1444 1444 c, t dbSNP:762494949
1445 1445 a, c, g dbSNP:766988109
1455 1455 c, t dbSNP:369978649
1460 1460 c, g dbSNP:201471936
1463 1463 c, g dbSNP:772431056
1467 1467 c, g dbSNP:121907958
1471 1471 c, g dbSNP:774562271
1473 1473 g, t dbSNP:373023700
1478 1478 a, g dbSNP:535095877
1482 1482 a, g dbSNP:749368995
1484 1484 -, tatc dbSNP:387906309
1485 1485 c, t dbSNP:780010367
1487 1487 a, g dbSNP:756026917
1497 1497 c, g dbSNP:745772223
1503 1503 a, g, t dbSNP:757010519
1509 1509 c, g dbSNP:202173526
1512 1512 c, t dbSNP:587779406
1513 1513 a, g dbSNP:1800431
1514 1514 -, ta dbSNP:777042785
1514 1514 c, t dbSNP:758048549
1526 1526 c, t dbSNP:752223090
1538 1538 c, g dbSNP:754440146
1543 1543 c, t dbSNP:750903859
1545 1545 c, t dbSNP:34085965
1546 1546 a, g dbSNP:758066266
1553 1553 a, g dbSNP:751934469
1558 1558 c, g dbSNP:28940871
1566 1566 c, t dbSNP:113941121
1567 1567 a, g dbSNP:121907978
1581 1581 c, t dbSNP:764396757
1582 1582 a, g, t dbSNP:547192168
1589 1589 a, g dbSNP:375019490
1599 1599 a, g dbSNP:759649066
1600 1600 a, g dbSNP:750727201
1604 1604 a, g dbSNP:200936836
1606 1606 a, g dbSNP:765590079
1607 1607 c, g dbSNP:746828145
1612 1612 c, g dbSNP:777731446
1617 1617 c, g dbSNP:771951380
1623 1623 c, g dbSNP:369117208
1628 1628 g, t dbSNP:762374961
1629 1629 c, g dbSNP:121907981
1631 1631 c, g dbSNP:758829206
1642 1642 a, g dbSNP:145012038
1645 1645 a, g dbSNP:370638338
1646 1646 c, t dbSNP:376929315
1650 1650 c, t dbSNP:140091006
1651 1651 a, g dbSNP:121907952
1655 1655 a, g dbSNP:766483588
1657 1657 a, c dbSNP:760775455
1660 1660 c, t dbSNP:121907968
1668 1668 a, c dbSNP:773338562
1681 1681 c, g dbSNP:767554113
1682 1682 a, g dbSNP:761736583
1684 1684 c, t dbSNP:774313739
1694 1694 c, g dbSNP:373781108
1697 1697 a, g dbSNP:147502219
1702 1702 c, t dbSNP:121907966
1703 1703 a, g dbSNP:121907956
1717 1717 c, t dbSNP:28942071
1718 1718 a, g, t dbSNP:121907955
1724 1724 a, g dbSNP:778293061
1725 1725 a, c, g, t dbSNP:4777502
1735 1735 c, t dbSNP:786204585
1736 1736 a, g dbSNP:745432499
1738 1738 a, g dbSNP:776140080
1740 1740 g, t dbSNP:761249905
1752 1752 a, g dbSNP:369398952
1753 1753 a, c dbSNP:748656870
1757 1757 c, t dbSNP:779228289
1758 1758 c, g dbSNP:769119115
1761 1761 c, t dbSNP:749609063
1798 1798 c, g dbSNP:780359821
1809 1809 c, t dbSNP:532797279
1810 1810 a, g dbSNP:750636737
1814 1814 a, g dbSNP:781430079
1815 1815 g, t dbSNP:757357289
1816 1816 g, t dbSNP:751574516
1826 1826 c, g dbSNP:763935887
1837 1837 a, g dbSNP:762847297
1839 1839 a, g dbSNP:752413673
1842 1842 a, g dbSNP:764962743
1846 1846 c, t dbSNP:759216964
1873 1873 a, g dbSNP:558918292
1876 1876 -, c dbSNP:751432099
1876 1876 c, t dbSNP:181233715
1878 1878 a, g dbSNP:531838039
1891 1891 g, t dbSNP:759741558
1908 1908 a, g dbSNP:561029456
1930 1930 a, g dbSNP:775801706
1936 1936 c, t dbSNP:375308096
1953 1953 c, t dbSNP:527803610
1971 1971 a, g dbSNP:751716928
1979 1979 -, t dbSNP:34300017
1980 1980 a, g dbSNP:1054432
2017 2017 -, a dbSNP:563352066
2045 2045 a, c dbSNP:766460302
2065 2065 c, g dbSNP:763246017
2066 2066 c, t dbSNP:560068788
2090 2090 a, g dbSNP:545085202
2115 2115 g, t dbSNP:139968433
2152 2152 c, g dbSNP:188399769
2164 2164 c, t dbSNP:184059814
2172 2172 c, t dbSNP:768562754
2177 2177 a, g dbSNP:760592453
2197 2197 a, g dbSNP:573845046
2200 2200 c, t dbSNP:775453371
2221 2221 a, c dbSNP:555620598
2233 2233 c, t dbSNP:112626309
2234 2234 a, g dbSNP:560253606
2312 2312 a, g dbSNP:3087652
2335 2335 c, t dbSNP:778510381
2346 2346 c, g dbSNP:60288568
2366 2366 c, t dbSNP:770433545
2372 2372 a, g dbSNP:76075374
2386 2386 g, t dbSNP:11629508
2407 2407 a, t dbSNP:550241078
2427 2427 a, g dbSNP:35949555
2428 2428 c, t dbSNP:747982224

Target ORF information:

RefSeq Version NM_000520
Organism Homo sapiens (human)
Definition Homo sapiens hexosaminidase A (alpha polypeptide) (HEXA), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_000520

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGACAAGCT CCAGGCTTTG GTTTTCGCTG CTGCTGGCGG CAGCGTTCGC AGGACGGGCG 
ACGGCCCTCT GGCCCTGGCC TCAGAACTTC CAAACCTCCG ACCAGCGCTA CGTCCTTTAC
CCGAACAACT TTCAATTCCA GTACGATGTC AGCTCGGCCG CGCAGCCCGG CTGCTCAGTC
CTCGACGAGG CCTTCCAGCG CTATCGTGAC CTGCTTTTCG GTTCCGGGTC TTGGCCCCGT
CCTTACCTCA CAGGGAAACG GCATACACTG GAGAAGAATG TGTTGGTTGT CTCTGTAGTC
ACACCTGGAT GTAACCAGCT TCCTACTTTG GAGTCAGTGG AGAATTATAC CCTGACCATA
AATGATGACC AGTGTTTACT CCTCTCTGAG ACTGTCTGGG GAGCTCTCCG AGGTCTGGAG
ACTTTTAGCC AGCTTGTTTG GAAATCTGCT GAGGGCACAT TCTTTATCAA CAAGACTGAG
ATTGAGGACT TTCCCCGCTT TCCTCACCGG GGCTTGCTGT TGGATACATC TCGCCATTAC
CTGCCACTCT CTAGCATCCT GGACACTCTG GATGTCATGG CGTACAATAA ATTGAACGTG
TTCCACTGGC ATCTGGTAGA TGATCCTTCC TTCCCATATG AGAGCTTCAC TTTTCCAGAG
CTCATGAGAA AGGGGTCCTA CAACCCTGTC ACCCACATCT ACACAGCACA GGATGTGAAG
GAGGTCATTG AATACGCACG GCTCCGGGGT ATCCGTGTGC TTGCAGAGTT TGACACTCCT
GGCCACACTT TGTCCTGGGG ACCAGGTATC CCTGGATTAC TGACTCCTTG CTACTCTGGG
TCTGAGCCCT CTGGCACCTT TGGACCAGTG AATCCCAGTC TCAATAATAC CTATGAGTTC
ATGAGCACAT TCTTCTTAGA AGTCAGCTCT GTCTTCCCAG ATTTTTATCT TCATCTTGGA
GGAGATGAGG TTGATTTCAC CTGCTGGAAG TCCAACCCAG AGATCCAGGA CTTTATGAGG
AAGAAAGGCT TCGGTGAGGA CTTCAAGCAG CTGGAGTCCT TCTACATCCA GACGCTGCTG
GACATCGTCT CTTCTTATGG CAAGGGCTAT GTGGTGTGGC AGGAGGTGTT TGATAATAAA
GTAAAGATTC AGCCAGACAC AATCATACAG GTGTGGCGAG AGGATATTCC AGTGAACTAT
ATGAAGGAGC TGGAACTGGT CACCAAGGCC GGCTTCCGGG CCCTTCTCTC TGCCCCCTGG
TACCTGAACC GTATATCCTA TGGCCCTGAC TGGAAGGATT TCTACATAGT GGAACCCCTG
GCATTTGAAG GTACCCCTGA GCAGAAGGCT CTGGTGATTG GTGGAGAGGC TTGTATGTGG
GGAGAATATG TGGACAACAC AAACCTGGTC CCCAGGCTCT GGCCCAGAGC AGGGGCTGTT
GCCGAAAGGC TGTGGAGCAA CAAGTTGACA TCTGACCTGA CATTTGCCTA TGAACGTTTG
TCACACTTCC GCTGTGAATT GCTGAGGCGA GGTGTCCAGG CCCAACCCCT CAATGTAGGC
TTCTGTGAGC AGGAGTTTGA ACAGACCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.