||ORF Nucleotide Sequence (Length: 822bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||HLA class II histocompatibility antigen, DO beta chain precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM152694.1, BC006097.1 and
This sequence is a reference standard in the RefSeqGene project.
On Nov 24, 2006 this sequence version replaced gi:18641377.
Summary: HLA-DOB belongs to the HLA class II beta chain paralogues.
This class II molecule is a heterodimer consisting of an alpha
(DOA) and a beta chain (DOB), both anchored in the membrane. It is
located in intracellular vesicles. DO suppresses peptide loading of
MHC class II molecules by inhibiting HLA-DM. Class II molecules are
expressed in antigen presenting cells (APC: B lymphocytes,
dendritic cells, macrophages). The beta chain is approximately
26-28 kDa and its gene contains 6 exons. Exon one encodes the
leader peptide, exons 2 and 3 encode the two extracellular domains,
exon 4 encodes the transmembrane domain and exon 5 encodes the
cytoplasmic tail. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC006097.1, AY645723.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.