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HIST2H2AB cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST2H2AB
Entrez Gene ID 317772
Full Name histone cluster 2, H2ab
Synonyms H2AB
General protein information
Preferred Names
histone H2A type 2-B
Names
histone H2A type 2-B
histone 2, H2ab
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

615014

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_175065 NP_778235 histone H2A type 2-B

KEGG
hsa05322 Systemic lupus erythematosus
hsa05034 Alcoholism
Reactome
R-HSA-4839726 Chromatin organization
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214858 RMTs methylate histone arginines


Homo sapiens (human) HIST2H2AB NP_778235.1
Pan troglodytes (chimpanzee) LOC746557 XP_001166488.1
Macaca mulatta (Rhesus monkey) HIST2H2AB XP_001096734.1
Canis lupus familiaris (dog) LOC100855609 XP_003639665.1
Bos taurus (cattle) HIST2H2AB XP_002686098.1
Mus musculus (house mouse) Hist2h2ab NP_835585.3
Rattus norvegicus (Norway rat) Hist2h2ab NP_001104811.1
Danio rerio (zebrafish) zgc:101846 NP_001005967.1
Danio rerio (zebrafish) zgc:173652 NP_001096634.1
Danio rerio (zebrafish) LOC565202 XP_693579.2
Danio rerio (zebrafish) LOC559220 XP_005163276.1
Danio rerio (zebrafish) LOC100000574 XP_001334871.1
Danio rerio (zebrafish) LOC100004510 XP_001337024.1
Danio rerio (zebrafish) LOC100001004 XP_001335390.1
Danio rerio (zebrafish) LOC100151041 XP_001920286.4
Danio rerio (zebrafish) zgc:114037 NP_001026996.1
Danio rerio (zebrafish) zgc:110434 XP_005168861.1
Danio rerio (zebrafish) LOC100004768 XP_001338956.1
Danio rerio (zebrafish) si:ch211-113a14.7 XP_005163251.1
Danio rerio (zebrafish) LOC100536331 XP_005163253.1
Danio rerio (zebrafish) LOC100334621 XP_003201515.1
Danio rerio (zebrafish) si:ch211-113a14.19 XP_689030.3
Danio rerio (zebrafish) LOC100334934 XP_002666988.1
Danio rerio (zebrafish) LOC570115 XP_698647.2
Danio rerio (zebrafish) zgc:195633 NP_001136058.1
Danio rerio (zebrafish) si:ch211-113a14.16 XP_688798.1
Drosophila melanogaster (fruit fly) His2A:CG33853 NP_001027366.1
Drosophila melanogaster (fruit fly) His2A:CG33859 NP_001027376.1
Drosophila melanogaster (fruit fly) His2A:CG33856 NP_001027371.1
Arabidopsis thaliana (thale cress) HTA13 NP_188703.1
Arabidopsis thaliana (thale cress) HTA10 NP_175517.1
Arabidopsis thaliana (thale cress) RAT5 NP_200275.1
Arabidopsis thaliana (thale cress) HTA2 NP_194453.1
Xenopus (Silurana) tropicalis (western clawed frog) hist1h2aj NP_001004821.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100497456 XP_002942896.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC101730761 XP_004919903.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487067 XP_002942196.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100491383 XP_004920491.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100494316 XP_002944390.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731295 XP_004919909.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101730817 XP_004913914.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492975 XP_002942386.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100496752 XP_004919336.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101732908 XP_004917038.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101733656 XP_004917046.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100496440 XP_002942346.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100495988 XP_002942343.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101734285 XP_004917055.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101734557 XP_004917059.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100495625 XP_004917049.1
Xenopus (Silurana) tropicalis (western clawed frog) hist1h2ah NP_001120117.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731908 XP_004919470.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100497241 XP_002943147.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100496919 XP_004919471.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101733262 XP_004917645.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487632 XP_002940905.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100488074 XP_002943225.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100493706 XP_002945549.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731897 XP_004913865.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485081 XP_002940826.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100496089 XP_002943318.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487588 XP_002943222.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100496244 XP_002943319.1
Xenopus (Silurana) tropicalis (western clawed frog) hist1h2ad NP_001025503.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101730371 XP_004914345.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100495187 XP_002943526.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485548 XP_002940829.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101730347 XP_004913908.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101735276 XP_004913905.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101734842 XP_004913902.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100489065 XP_004913895.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101733880 XP_004913892.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101733986 XP_004913893.1
Xenopus (Silurana) tropicalis (western clawed frog) hist2h2ab NP_001025496.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100488903 XP_004913875.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101732823 XP_004912080.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100497614 XP_004919929.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487526 XP_002940841.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492873 XP_002944658.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101735111 XP_004915675.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101734900 XP_004919083.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492813 XP_002942385.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100486008 XP_004919104.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101732059 XP_004919109.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731006 XP_004919327.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485854 XP_002941404.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100488021 XP_002942202.2

Component

ID Name Evidence
GO:0000786 nucleosome IEA
GO:0005634 nucleus IEA
GO:0005694 chromosome IEA

Function

ID Name Evidence
GO:0003677 DNA binding IEA

Process

ID Name Evidence
GO:0006334 nucleosome assembly IEA

The following HIST2H2AB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST2H2AB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu14009 NM_175065 Homo sapiens histone cluster 2, H2ab (HIST2H2AB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu14009
Accession Version NM_175065.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 393bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H2A type 2-B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY131972.1. On Mar 25, 2003 this sequence version replaced gi:28195393. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGTCAGGAC GCGGAAAGCA GGGAGGCAAG GCCCGCGCTA AGGCCAAGTC GCGCTCGTCC 
CGCGCTGGTC TCCAGTTCCC GGTGGGGCGA GTGCACCGCT TGCTGCGCAA AGGCAACTAC
GCGGAGCGGG TCGGGGCAGG CGCCCCGGTG TACCTGGCGG CGGTCCTCGA GTACCTGACC
GCGGAAATTC TGGAGCTGGC GGGCAACGCG GCTCGGGACA ACAAGAAGAC GCGCATCATC
CCTCGCCATC TGCAACTAGC CGTGAGGAAT GACGAAGAGC TCAACAAGTT ACTCGGGGGT
GTCACCATTG CCCAGGGCGG CGTCTTGCCC AATATCCAGG CTGTCCTGTT GCCCAAGAAA
ACGGAGAGTC ACAAGCCTGG CAAGAACAAG TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_778235.1
CDS1..393
Misc Feature(1)1..390(+)
Misc Feature(2)4..6(+)
Misc Feature(3)4..6(+)
Misc Feature(4)10..12(+)
Misc Feature(5)10..12(+)
Misc Feature(6)16..360(+)
Misc Feature(7)16..30(+)
Misc Feature(8)16..18(+)
Misc Feature(9)88..234(+)
Misc Feature(10)109..111(+)
Misc Feature(11)115..126(+)
Misc Feature(12)154..192(+)
Misc Feature(13)313..315(+)
Misc Feature(14)355..357(+)
Misc Feature(15)358..360(+)
Misc Feature(16)358..360(+)
Misc Feature(17)361..363(+)
Misc Feature(18)367..369(+)
Exon (1)1..448
Gene:HIST2H2AB
Gene Synonym:
Translation
Position Chain Variation Link
137 137 a, c, t dbSNP:200774928
311 311 c, t dbSNP:745933110
394 394 -, ttaa dbSNP:781752502
408 408 a, t dbSNP:12118591

Target ORF information:

RefSeq Version NM_175065
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 2, H2ab (HIST2H2AB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_175065

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTCAGGAC GCGGAAAGCA GGGAGGCAAG GCCCGCGCTA AGGCCAAGTC GCGCTCGTCC 
CGCGCTGGTC TCCAGTTCCC GGTGGGGCGA GTGCACCGCT TGCTGCGCAA AGGCAACTAC
GCGGAGCGGG TCGGGGCAGG CGCCCCGGTG TACCTGGCGG CGGTCCTCGA GTACCTGACC
GCGGAAATTC TGGAGCTGGC GGGCAACGCG GCTCGGGACA ACAAGAAGAC GCGCATCATC
CCTCGCCATC TGCAACTAGC CGTGAGGAAT GACGAAGAGC TCAACAAGTT ACTCGGGGGT
GTCACCATTG CCCAGGGCGG CGTCTTGCCC AATATCCAGG CTGTCCTGTT GCCCAAGAAA
ACGGAGAGTC ACAAGCCTGG CAAGAACAAG TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants
Neurotox Res 27 (1), 84-97 (2015)
Sadakierska-Chudy A, Kostrzewa RM and Filip M.


book

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
Proteomics 13 (10-11), 1667-1671 (2013)
Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T and Drake RR.


book

Proteomic characterization of the human sperm nucleus
Proteomics 11 (13), 2714-2726 (2011)
de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.


book

Large-scale proteomics and phosphoproteomics of urinary exosomes
J. Am. Soc. Nephrol. 20 (2), 363-379 (2009)
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS and Knepper MA.


book

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A
Genes Dev. 20 (10), 1343-1352 (2006)
Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W and Dantuma NP.


book

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter
EMBO J. 22 (24), 6550-6561 (2003)
Lusic M, Marcello A, Cereseto A and Giacca M.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
Virology 289 (2), 312-326 (2001)
Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P and Kashanchi F.


book

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones
Virology 277 (2), 278-295 (2000)
Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG and Kashanchi F.


book

Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter
Mol. Cell. Biol. 18 (5), 2535-2544 (1998)
El Kharroubi A, Piras G, Zensen R and Martin MA.


 
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