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ERAS ES cell expressed Ras [Homo sapiens (human)]

Gene Symbol ERAS
Entrez Gene ID 3266
Full Name ES cell expressed Ras
Synonyms HRAS2, HRASP
General protein information
Preferred Names
GTPase ERas
Names
GTPase ERas
E-Ras
small GTPase protein E-Ras
embryonic stem cell-expressed Ras
v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2
v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.23

Summary This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]. lac of sum
Disorder MIM:

300437

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu07581 NM_181532 Homo sapiens ES cell expressed Ras (ERAS), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu07581D
Sequence Information ORF Nucleotide Sequence (Length: 702bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product GTPase ERas precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY043532.1 and BC101642.1. On Dec 5, 2012 this sequence version replaced gi:31581555. Summary: This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY043532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCTGC CAACAAAGCC TGGCACCTTC GACCTGGGCC TGGCCACATG GAGCCCTTCC 
TTCCAGGGGG AAACCCACCG GGCTCAGGCA CGCCGCAGGG ATGTTGGCAG GCAGCTGCCT
GAGTACAAGG CTGTGGTGGT GGGCGCCAGT GGCGTGGGCA AGAGTGCGCT GACCATCCAG
CTGAACCACC AGTGCTTCGT GGAGGACCAC GACCCCACCA TCCAGGATTC CTACTGGAAG
GAGTTGACCC TGGACAGTGG GGACTGCATT CTGAATGTGC TGGACACAGC AGGGCAGGCC
ATCCATAGGG CCCTGCGTGA CCAGTGCCTG GCTGTCTGTG ATGGTGTGCT GGGCGTCTTC
GCTCTCGATG ACCCCTCGTC TCTGATCCAG CTGCAGCAGA TATGGGCCAC CTGGGGCCCT
CACCCCGCCC AGCCCCTTGT CCTCGTGGGC AACAAGTGTG ACCTTGTGAC CACTGCTGGA
GATGCTCATG CCGCTGCTGC AGCCCTCGCA CACAGCTGGG GGGCCCACTT CGTGGAGACC
TCGGCCAAAA CACGGCAAGG CGTGGAGGAG GCCTTTTCCC TGCTGGTCCA TGAGATCCAG
AGGGTCCAGG AGGCCATGGC GAAGGAGCCC ATGGCAAGGT CCTGTAGGGA GAAGACCCGG
CACCAGAAGG CCACCTGCCA CTGTGGCTGC TCTGTGGCCTT GA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_853510.1
CDS81..782
Misc Feature(1)201..746(+)
Misc Feature(2)204..683(+)
Misc Feature(3)222..245(+)
Misc Feature(4)225..491(+)
Misc Feature(5)228..626(+)
Misc Feature(6)243..629(+)
Misc Feature(7)267..647(+)
Misc Feature(8)288..314(+)
Misc Feature(9)291..314(+)
Misc Feature(10)297..299(+)
Misc Feature(11)363..374(+)
Misc Feature(12)369..425(+)
Misc Feature(13)531..542(+)
Misc Feature(14)567..617(+)
Misc Feature(15)621..629(+)
Exon (1)1..37
Gene:ERAS
Gene Synonym:
Exon (2)38..826
Gene:ERAS
Gene Synonym:
Translation
Position Chain Variation Link
173 173 c, t dbSNP:111320229
573 573 a, g dbSNP:199842596

Target ORF information:

RefSeq Version NM_181532
Organism Homo sapiens (human)
Definition Homo sapiens ES cell expressed Ras (ERAS), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_181532

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCTGC CAACAAAGCC TGGCACCTTC GACCTGGGCC TGGCCACATG GAGCCCTTCC 
TTCCAGGGGG AAACCCACCG GGCTCAGGCA CGCCGCAGGG ATGTTGGCAG GCAGCTGCCT
GAGTACAAGG CTGTGGTGGT GGGCGCCAGT GGCGTGGGCA AGAGTGCGCT GACCATCCAG
CTGAACCACC AGTGCTTCGT GGAGGACCAC GACCCCACCA TCCAGGATTC CTACTGGAAG
GAGTTGACCC TGGACAGTGG GGACTGCATT CTGAATGTGC TGGACACAGC AGGGCAGGCC
ATCCATAGGG CCCTGCGTGA CCAGTGCCTG GCTGTCTGTG ATGGTGTGCT GGGCGTCTTC
GCTCTCGATG ACCCCTCGTC TCTGATCCAG CTGCAGCAGA TATGGGCCAC CTGGGGCCCT
CACCCCGCCC AGCCCCTTGT CCTCGTGGGC AACAAGTGTG ACCTTGTGAC CACTGCTGGA
GATGCTCATG CCGCTGCTGC AGCCCTCGCA CACAGCTGGG GGGCCCACTT CGTGGAGACC
TCGGCCAAAA CACGGCAAGG CGTGGAGGAG GCCTTTTCCC TGCTGGTCCA TGAGATCCAG
AGGGTCCAGG AGGCCATGGC GAAGGAGCCC ATGGCAAGGT CCTGTAGGGA GAAGACCCGG
CACCAGAAGG CCACCTGCCA CTGTGGCTGC TCTGTGGCCTT GA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.