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HSPA1A heat shock 70kDa protein 1A [Homo sapiens (human)]

Gene Symbol HSPA1A
Entrez Gene ID 3303
Full Name heat shock 70kDa protein 1A
Synonyms HEL-S-103, HSP70-1, HSP70-1A, HSP70.1, HSP70I, HSP72, HSPA1
General protein information
Preferred Names
heat shock 70 kDa protein 1A/1B
Names
heat shock 70 kDa protein 1A/1B
HSP70-1/HSP70-2
HSP70.1/HSP70.2
heat shock 70kD protein 1A
heat shock-induced protein
heat shock 70 kDa protein 1/2
dnaK-type molecular chaperone HSP70-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

140550

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu15193 NM_005345 Homo sapiens heat shock 70kDa protein 1A (HSPA1A), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu15193D
Sequence Information ORF Nucleotide Sequence (Length: 1926bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 06-APR-2014
Organism Homo sapiens (human)
Product heat shock 70 kDa protein 1A/1B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA486842.1, AK225692.1, DA256622.1, AK096017.1 and BC002453.2. On Jul 15, 2008 this sequence version replaced gi:26787973. Summary: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC
AAGATCAGCG AGGCGGACAA GAAGAAGGTG CTGGACAAGT GTCAAGAGGT CATCTCGTGG
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGG
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCCACCAT TGAGGAGGTA
GATTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_005336.3
CDS244..2169
Misc Feature(1)244..2076(+)
Misc Feature(2)247..249(+)
Misc Feature(3)259..1386(+)
Misc Feature(4)271..1341(+)
Misc Feature(5)310..1269(+)
Misc Feature(6)340..1125(+)
Misc Feature(7)565..567(+)
Misc Feature(8)697..1218(+)
Misc Feature(9)979..981(+)
Misc Feature(10)1285..1287(+)
Misc Feature(11)1924..1926(+)
Misc Feature(12)2134..2136(+)
Misc Feature(13)2140..2142(+)
Misc Feature(14)2149..2151(+)
Exon (1)1..2429
Gene:HSPA1A
Gene Synonym:
Translation
Position Chain Variation Link
17 17 a, g dbSNP:533953045
18 18 a, c dbSNP:189634153
36 36 c, t dbSNP:759024509
44 44 a, g dbSNP:574264572
46 46 a, t dbSNP:544785546
49 49 g, t dbSNP:563124166
53 53 a, g dbSNP:34397183
59 59 g, t dbSNP:545956390
62 62 c, t dbSNP:771768145
86 86 a, c dbSNP:33934112
114 114 c, g dbSNP:34201669
116 116 c, t dbSNP:546281054
121 121 a, g dbSNP:561977200
147 147 c, t dbSNP:11557922
174 174 c, g dbSNP:35551252
180 180 a, g dbSNP:11576009
195 195 c, t dbSNP:779472283
203 203 c, g dbSNP:749808292
204 204 c, g dbSNP:755567698
207 207 a, g dbSNP:201753050
216 216 a, c dbSNP:41269725
216 216 a, c, t dbSNP:570952225
217 217 c, g, t dbSNP:1043618
217 217 -, g dbSNP:761312038
218 218 a, c, g dbSNP:373368529
222 222 c, t dbSNP:776798711
223 223 -, ga dbSNP:771614502
223 223 c, g dbSNP:200771637
225 225 a, c dbSNP:764128104
226 226 -, agag dbSNP:773181962
226 226 -, ag dbSNP:760554980
226 226 a, c dbSNP:374251722
227 227 c, g dbSNP:761688385
233 233 a, g dbSNP:376057829
235 235 a, g dbSNP:750079842
236 236 a, g dbSNP:755705482
237 237 a, c dbSNP:2242667
240 240 c, g, t dbSNP:374399750
241 241 c, g dbSNP:779524645
248 248 c, t dbSNP:748557276
261 261 a, g dbSNP:758825405
264 264 c, g dbSNP:778220828
265 265 c, g dbSNP:747251905
270 270 a, c, g dbSNP:771342261
274 274 c, t dbSNP:746006724
278 278 a, g dbSNP:769712470
279 279 c, t dbSNP:774374754
289 289 c, t dbSNP:200520712
290 290 a, c dbSNP:367576856
291 291 c, g dbSNP:767312593
294 294 c, t dbSNP:773049398
295 295 a, g dbSNP:202172229
301 301 g, t dbSNP:766060629
302 302 g, t dbSNP:753411347
304 304 a, t dbSNP:368507842
308 308 a, g dbSNP:764614987
318 318 a, g dbSNP:753256218
326 326 g, t dbSNP:758776902
327 327 a, c dbSNP:778415099
330 330 c, t dbSNP:752008493
331 331 a, g dbSNP:199499427
349 349 c, t dbSNP:757670500
352 352 a, g dbSNP:781585045
356 356 c, g dbSNP:746034999
357 357 c, t dbSNP:769919328
362 362 a, g dbSNP:779938408
377 377 c, g, t dbSNP:749373372
378 378 a, g dbSNP:773102740
384 384 c, g, t dbSNP:760514487
385 385 a, g dbSNP:201204185
408 408 c, t dbSNP:368717500
411 411 c, g dbSNP:759046329
412 412 a, c dbSNP:764821183
415 415 c, t dbSNP:752211354
422 422 c, t dbSNP:762517250
428 428 -, c dbSNP:766129354
432 432 a, g dbSNP:764742888
435 435 a, g dbSNP:752061501
450 450 c, g dbSNP:757725542
453 453 a, g dbSNP:534159834
456 456 c, g dbSNP:750670211
457 457 c, t dbSNP:756347651
458 458 a, g dbSNP:780318868
460 460 c, t dbSNP:749367757
465 465 c, t dbSNP:1043620
465 465 c, t dbSNP:28491949
469 469 c, t dbSNP:777711495
471 471 c, t dbSNP:746911355
483 483 c, t dbSNP:770719538
489 489 g, t dbSNP:776233825
510 510 c, t dbSNP:567948268
530 530 a, g dbSNP:759366790
534 534 c, t dbSNP:769403730
553 553 c, g dbSNP:775181598
573 573 c, g dbSNP:562047
573 573 c, g dbSNP:17856061
591 591 c, t dbSNP:12190359
591 591 c, t dbSNP:145154321
613 613 c, t dbSNP:556781423
822 822 c, g dbSNP:113843823
1296 1296 a, g dbSNP:1061581
1639 1639 c, t dbSNP:578191843
1739 1739 a, g dbSNP:762351513
1740 1740 c, g dbSNP:768054024
1788 1788 a, c, g dbSNP:750819847
1794 1794 c, t dbSNP:766558978
1795 1795 a, g dbSNP:754012082
1823 1823 c, t dbSNP:755082889
1826 1826 -, g dbSNP:753585612
1828 1828 a, g dbSNP:778899955
1850 1850 c, t dbSNP:746965839
1853 1853 -, c dbSNP:759458392
1853 1853 c, t dbSNP:757246842
1878 1878 c, g, t dbSNP:781188477
1897 1897 a, c, g dbSNP:769578848
1899 1899 c, t dbSNP:748880673
1900 1900 a, g dbSNP:768292679
1903 1903 a, g dbSNP:774061665
1911 1911 -, g dbSNP:765552470
1912 1912 a, g dbSNP:761403622
1917 1917 c, g dbSNP:371873691
1918 1918 a, g dbSNP:144685460
1926 1926 -, atcagc dbSNP:753007938
1926 1926 a, g dbSNP:760960640
1932 1932 c, t dbSNP:374175801
1936 1936 g, t dbSNP:147878843
1938 1938 a, c, g dbSNP:506770
1938 1938 c, g dbSNP:33998554
1943 1943 a, g dbSNP:752811220
1948 1948 a, g dbSNP:758495885
1949 1949 a, t dbSNP:781009367
1950 1950 a, g dbSNP:745755836
1953 1953 g, t dbSNP:541340
1957 1957 a, g dbSNP:779947748
1962 1962 a, g dbSNP:191385827
1972 1972 a, g dbSNP:768464421
1979 1979 c, t dbSNP:774143469
1985 1985 c, t dbSNP:747719061
1989 1989 c, t dbSNP:771552351
1998 1998 c, g, t dbSNP:773596627
2004 2004 c, t dbSNP:766673421
2005 2005 a, g dbSNP:777027010
2013 2013 c, g, t dbSNP:199729109
2018 2018 c, t dbSNP:540214133
2028 2028 -, c dbSNP:35075242
2031 2031 a, g dbSNP:762950219
2033 2033 a, c dbSNP:764197379
2034 2034 c, g dbSNP:750353273
2037 2037 -, c dbSNP:758529299
2038 2038 c, t dbSNP:756128298
2040 2040 a, g dbSNP:780109763
2046 2046 a, g dbSNP:753754553
2047 2047 a, g dbSNP:754807027
2050 2050 g, t dbSNP:778721578
2055 2055 a, c dbSNP:747768908
2056 2056 c, t dbSNP:771512819
2057 2057 c, g dbSNP:777286374
2059 2059 a, c dbSNP:746476471
2060 2060 c, t dbSNP:771505399
2061 2061 c, g dbSNP:777114966
2067 2067 c, t dbSNP:765239235
2068 2068 a, g dbSNP:759946698
2071 2071 c, t dbSNP:561574210
2086 2086 a, g dbSNP:775724932
2087 2087 a, g dbSNP:763188460
2092 2092 a, c dbSNP:764202242
2095 2095 a, g dbSNP:751703293
2096 2096 a, g dbSNP:761795494
2097 2097 c, g dbSNP:766482400
2098 2098 c, t dbSNP:753771041
2101 2101 a, g dbSNP:754825210
2103 2103 c, g dbSNP:778809676
2104 2104 a, g dbSNP:752313605
2105 2105 g, t dbSNP:758117058
2107 2107 a, t dbSNP:777256711
2109 2109 c, t dbSNP:746592204
2110 2110 a, g dbSNP:770410665
2129 2129 g, t dbSNP:781669728
2141 2141 c, t dbSNP:529162552
2148 2148 a, c, g, t dbSNP:508603
2149 2149 a, g dbSNP:775974928
2155 2155 -, gag dbSNP:777736210
2163 2163 a, c, g, t dbSNP:508633
2164 2164 g, t dbSNP:768990311
2173 2173 -, c dbSNP:752068654
2182 2182 c, g dbSNP:774424456
2185 2185 g, t dbSNP:761966416
2194 2194 c, t dbSNP:562455991
2199 2199 c, t dbSNP:199732319
2213 2213 -, tt dbSNP:757711628
2225 2225 a, g dbSNP:532931636
2254 2254 c, t dbSNP:376942723
2264 2264 a, g dbSNP:551174012
2307 2307 c, t dbSNP:566619820
2308 2308 a, g dbSNP:368938912
2309 2309 a, g dbSNP:527830727
2319 2319 a, g dbSNP:750583276
2329 2329 a, c dbSNP:549339651
2356 2356 c, t dbSNP:758541631
2385 2385 -, t dbSNP:41269729
2404 2404 -, a dbSNP:34629121

Target ORF information:

RefSeq Version NM_005345
Organism Homo sapiens (human)
Definition Homo sapiens heat shock 70kDa protein 1A (HSPA1A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_005345

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC
AAGATCAGCG AGGCGGACAA GAAGAAGGTG CTGGACAAGT GTCAAGAGGT CATCTCGTGG
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGG
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCCACCAT TGAGGAGGTA
GATTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.