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APOA1 apolipoprotein A-I [Homo sapiens (human)]

Gene Symbol APOA1
Entrez Gene ID 335
Full Name apolipoprotein A-I
Synonyms
General protein information
Preferred Names
apolipoprotein A-I
Names
apolipoprotein A-I
apo-AI
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23-q24

Summary This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

107680

Disorder Html: ApoA-I and apoC-III deficiency, combined (3);





The following APOA1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOA1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27099 XM_005271539 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$199
OHu27099 XM_005271540 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$199
OHu27099 NM_000039 Homo sapiens apolipoprotein A-I (APOA1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27099
Accession Version XM_005271539.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu27099D_COA.pdf (pdf)
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product apolipoprotein A-I isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_033899.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530398066. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005271596.1
CDS110..913
Misc Feature(1)383..883(+)
Translation
Position Chain Variation Link
29 29 a, g dbSNP:563005045
34 34 c, t dbSNP:543422728
98 98 c, t dbSNP:781068686
99 99 a, g dbSNP:199729971
118 118 c, t dbSNP:141383703
121 121 a, g dbSNP:368534370
136 136 c, t dbSNP:758732160
137 137 a, g dbSNP:750125257
139 139 a, g dbSNP:762675498
150 150 c, t dbSNP:778560581
151 151 a, g dbSNP:760255146
164 164 c, t dbSNP:371084971
165 165 c, g dbSNP:777407596
166 166 a, g, t dbSNP:571564084
176 176 c, t dbSNP:387906570
188 188 a, c, t dbSNP:200213347
189 189 a, c, g dbSNP:121912720
191 191 c, t dbSNP:751415951
192 192 c, g dbSNP:121912721
193 193 c, t dbSNP:369066087
194 194 -, c dbSNP:753348565
196 196 c, g dbSNP:751028421
197 197 a, g dbSNP:147246779
199 199 c, t dbSNP:563067047
200 200 c, g dbSNP:764283540
210 210 g, t dbSNP:28929476
217 217 a, g dbSNP:775510323
221 221 -, c dbSNP:768017979
221 221 c, t dbSNP:745889664
223 223 c, g dbSNP:772574430
225 225 c, t dbSNP:746314593
227 227 a, g dbSNP:774753857
229 229 g, t dbSNP:771194289
230 230 g, t dbSNP:201148448
236 236 a, c, g dbSNP:373545875
241 241 a, t dbSNP:755740688
247 247 c, t dbSNP:747688781
254 254 a, c dbSNP:780794079
255 255 g, t dbSNP:755026583
256 256 c, t dbSNP:757974682
257 257 a, c, g dbSNP:28931574
262 262 a, g dbSNP:758106382
267 267 a, g dbSNP:750185173
271 271 c, g dbSNP:193922099
275 275 c, t dbSNP:121912725
277 277 a, g dbSNP:760886281
285 285 g, t dbSNP:775559386
287 287 c, g, t dbSNP:199759119
289 289 c, t dbSNP:774804784
290 290 a, g dbSNP:12718465
292 292 c, t dbSNP:5071
294 294 g, t dbSNP:17407917
295 295 a, g dbSNP:763248522
297 297 -, g dbSNP:759977217
304 304 a, g dbSNP:773584936
307 307 a, g dbSNP:540974091
310 310 a, c dbSNP:746552681
319 319 -, cct dbSNP:770007065
320 320 c, g dbSNP:779553097
322 322 g, t dbSNP:565203809
329 329 c, t dbSNP:121912726
337 337 c, t dbSNP:771919707
343 343 c, t dbSNP:745802908
346 346 c, t dbSNP:375453486
350 350 g, t dbSNP:777403379
351 351 a, t dbSNP:757011774
360 360 g, t dbSNP:121912724
361 361 g, t dbSNP:752962410
364 364 a, c dbSNP:757902962
370 370 g, t dbSNP:143796163
373 373 c, g dbSNP:755152208
376 376 a, c dbSNP:751593786
379 379 g, t dbSNP:752390257
384 384 c, t dbSNP:766422306
388 388 a, g dbSNP:763439449
393 393 a, t dbSNP:138407155
396 396 a, g dbSNP:576348564
397 397 g, t dbSNP:201320308
405 405 c, t dbSNP:372520221
410 410 a, g dbSNP:143723530
411 411 a, g dbSNP:17145083
419 419 a, g dbSNP:763847275
421 421 g, t dbSNP:760348365
424 424 c, t dbSNP:148950234
431 431 c, t dbSNP:121912723
433 433 a, g dbSNP:2727787
436 436 a, g dbSNP:113733249
439 439 c, g dbSNP:745829293
448 448 c, g, t dbSNP:150243849
450 450 c, t dbSNP:28931575
465 465 c, t dbSNP:749111893
471 471 c, t dbSNP:777476426
472 472 a, g dbSNP:755205186
481 481 c, g dbSNP:747252682
484 484 g, t dbSNP:780038655
485 485 c, g dbSNP:5077
486 486 a, g dbSNP:758483455
498 498 a, g dbSNP:367866651
500 500 -, aag dbSNP:532489785
500 500 a, t dbSNP:121912716
501 501 a, t dbSNP:4882
510 510 a, g dbSNP:765880276
513 513 a, g dbSNP:757776512
516 516 g, t dbSNP:754271246
526 526 a, c dbSNP:764542484
527 527 c, t dbSNP:760468591
529 529 c, t dbSNP:775173438
534 534 a, g dbSNP:766981019
543 543 c, t dbSNP:373953986
544 544 c, g dbSNP:759104683
545 545 a, c, g, t dbSNP:544524212
562 562 a, g dbSNP:773694724
563 563 a, g dbSNP:574061789
586 586 a, c dbSNP:749164883
587 587 a, c, g dbSNP:121912718
589 589 g, t dbSNP:769548576
592 592 g, t dbSNP:747245248
594 594 a, c dbSNP:780347391
597 597 a, g dbSNP:758509542
601 601 a, c, g dbSNP:141429250
603 603 g, t dbSNP:779081481
607 607 a, c dbSNP:757899657
609 609 c, g dbSNP:121912719
611 611 c, g dbSNP:764591376
616 616 a, c, g dbSNP:370526470
617 617 a, g dbSNP:752951478
627 627 c, g dbSNP:387906571
635 635 a, g, t dbSNP:146623682
636 636 c, t dbSNP:751082973
641 641 -, gc dbSNP:781350389
648 648 a, t dbSNP:121912727
658 658 a, g dbSNP:765859780
660 660 c, g, t dbSNP:5078
664 664 c, g dbSNP:143182884
668 668 c, t dbSNP:1052925
671 671 g, t dbSNP:140770089
673 673 c, g dbSNP:558064576
675 675 c, g dbSNP:121912722
683 683 a, g dbSNP:201218000
685 685 c, g dbSNP:772355721
686 686 a, g dbSNP:746067683
691 691 c, g dbSNP:779203966
696 696 a, c dbSNP:771101090
698 698 c, t dbSNP:28931573
699 699 c, g dbSNP:121912728
702 702 c, t dbSNP:121912729
704 704 a, c, g dbSNP:121912730
706 706 c, g dbSNP:778443432
710 710 a, c dbSNP:756535387
711 711 a, g dbSNP:753109330
720 720 c, t dbSNP:781353714
726 726 a, g dbSNP:754715451
727 727 a, g dbSNP:5079
730 730 g, t dbSNP:751207751
743 743 a, g dbSNP:367638050
746 746 c, g dbSNP:762475205
751 751 c, g, t dbSNP:375529707
754 754 a, g dbSNP:199797843
757 757 c, t dbSNP:776551437
760 760 c, t dbSNP:372930229
761 761 c, g dbSNP:1053223
767 767 c, g dbSNP:759880182
771 771 c, g dbSNP:200394039
773 773 a, g dbSNP:121912717
775 775 a, g dbSNP:749406849
779 779 c, t dbSNP:14081
782 782 a, g dbSNP:777929592
787 787 c, g, t dbSNP:748589835
793 793 a, c dbSNP:781667498
794 794 a, g dbSNP:755277427
808 808 c, t dbSNP:536011950
815 815 a, g dbSNP:779713741
822 822 -, tcc dbSNP:768847919
822 822 c, t dbSNP:757980533
829 829 a, g dbSNP:773009729
833 833 a, c dbSNP:368503162
835 835 c, g dbSNP:567268961
836 836 c, g dbSNP:757288749
841 841 c, g dbSNP:5080
844 844 c, g dbSNP:763996092
858 858 a, g dbSNP:555795338
861 861 a, t dbSNP:760566805
870 870 g, t dbSNP:775381241
875 875 a, g dbSNP:766709243
890 890 a, g dbSNP:143430381
903 903 a, g dbSNP:761951364
905 905 -, aca dbSNP:747014491
908 908 c, t dbSNP:763209676
909 909 a, c dbSNP:773399124
916 916 c, t dbSNP:374998745
921 921 a, g dbSNP:748728104
928 928 c, t dbSNP:777027692
930 930 c, t dbSNP:370532459
932 932 a, c, g, t dbSNP:187335584
933 933 c, g, t dbSNP:374923795
935 935 -, t dbSNP:778143140
937 937 c, g dbSNP:531513949
940 940 a, g dbSNP:370384954
959 959 c, t dbSNP:763966714
960 960 c, t dbSNP:377370544
961 961 a, c dbSNP:752550293
963 963 a, g dbSNP:767406908
968 968 a, g dbSNP:3178226

Target ORF information:

RefSeq Version XM_005271539
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005271539

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27099
Accession Version XM_005271540.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu27099D_COA.pdf (pdf)
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product apolipoprotein A-I isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_033899.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005271597.1
CDS75..878
Misc Feature(1)348..848(+)
Translation
Position Chain Variation Link
44 44 c, t dbSNP:5069
45 45 a, g dbSNP:1799837
63 63 c, t dbSNP:781068686
64 64 a, g dbSNP:199729971
83 83 c, t dbSNP:141383703
86 86 a, g dbSNP:368534370
101 101 c, t dbSNP:758732160
102 102 a, g dbSNP:750125257
104 104 a, g dbSNP:762675498
115 115 c, t dbSNP:778560581
116 116 a, g dbSNP:760255146
129 129 c, t dbSNP:371084971
130 130 c, g dbSNP:777407596
131 131 a, g, t dbSNP:571564084
141 141 c, t dbSNP:387906570
153 153 a, c, t dbSNP:200213347
154 154 a, c, g dbSNP:121912720
156 156 c, t dbSNP:751415951
157 157 c, g dbSNP:121912721
158 158 c, t dbSNP:369066087
159 159 -, c dbSNP:753348565
161 161 c, g dbSNP:751028421
162 162 a, g dbSNP:147246779
164 164 c, t dbSNP:563067047
165 165 c, g dbSNP:764283540
175 175 g, t dbSNP:28929476
182 182 a, g dbSNP:775510323
186 186 -, c dbSNP:768017979
186 186 c, t dbSNP:745889664
188 188 c, g dbSNP:772574430
190 190 c, t dbSNP:746314593
192 192 a, g dbSNP:774753857
194 194 g, t dbSNP:771194289
195 195 g, t dbSNP:201148448
201 201 a, c, g dbSNP:373545875
206 206 a, t dbSNP:755740688
212 212 c, t dbSNP:747688781
219 219 a, c dbSNP:780794079
220 220 g, t dbSNP:755026583
221 221 c, t dbSNP:757974682
222 222 a, c, g dbSNP:28931574
227 227 a, g dbSNP:758106382
232 232 a, g dbSNP:750185173
236 236 c, g dbSNP:193922099
240 240 c, t dbSNP:121912725
242 242 a, g dbSNP:760886281
250 250 g, t dbSNP:775559386
252 252 c, g, t dbSNP:199759119
254 254 c, t dbSNP:774804784
255 255 a, g dbSNP:12718465
257 257 c, t dbSNP:5071
259 259 g, t dbSNP:17407917
260 260 a, g dbSNP:763248522
262 262 -, g dbSNP:759977217
269 269 a, g dbSNP:773584936
272 272 a, g dbSNP:540974091
275 275 a, c dbSNP:746552681
284 284 -, cct dbSNP:770007065
285 285 c, g dbSNP:779553097
287 287 g, t dbSNP:565203809
294 294 c, t dbSNP:121912726
302 302 c, t dbSNP:771919707
308 308 c, t dbSNP:745802908
311 311 c, t dbSNP:375453486
315 315 g, t dbSNP:777403379
316 316 a, t dbSNP:757011774
325 325 g, t dbSNP:121912724
326 326 g, t dbSNP:752962410
329 329 a, c dbSNP:757902962
335 335 g, t dbSNP:143796163
338 338 c, g dbSNP:755152208
341 341 a, c dbSNP:751593786
344 344 g, t dbSNP:752390257
349 349 c, t dbSNP:766422306
353 353 a, g dbSNP:763439449
358 358 a, t dbSNP:138407155
361 361 a, g dbSNP:576348564
362 362 g, t dbSNP:201320308
370 370 c, t dbSNP:372520221
375 375 a, g dbSNP:143723530
376 376 a, g dbSNP:17145083
384 384 a, g dbSNP:763847275
386 386 g, t dbSNP:760348365
389 389 c, t dbSNP:148950234
396 396 c, t dbSNP:121912723
398 398 a, g dbSNP:2727787
401 401 a, g dbSNP:113733249
404 404 c, g dbSNP:745829293
413 413 c, g, t dbSNP:150243849
415 415 c, t dbSNP:28931575
430 430 c, t dbSNP:749111893
436 436 c, t dbSNP:777476426
437 437 a, g dbSNP:755205186
446 446 c, g dbSNP:747252682
449 449 g, t dbSNP:780038655
450 450 c, g dbSNP:5077
451 451 a, g dbSNP:758483455
463 463 a, g dbSNP:367866651
465 465 -, aag dbSNP:532489785
465 465 a, t dbSNP:121912716
466 466 a, t dbSNP:4882
475 475 a, g dbSNP:765880276
478 478 a, g dbSNP:757776512
481 481 g, t dbSNP:754271246
491 491 a, c dbSNP:764542484
492 492 c, t dbSNP:760468591
494 494 c, t dbSNP:775173438
499 499 a, g dbSNP:766981019
508 508 c, t dbSNP:373953986
509 509 c, g dbSNP:759104683
510 510 a, c, g, t dbSNP:544524212
527 527 a, g dbSNP:773694724
528 528 a, g dbSNP:574061789
551 551 a, c dbSNP:749164883
552 552 a, c, g dbSNP:121912718
554 554 g, t dbSNP:769548576
557 557 g, t dbSNP:747245248
559 559 a, c dbSNP:780347391
562 562 a, g dbSNP:758509542
566 566 a, c, g dbSNP:141429250
568 568 g, t dbSNP:779081481
572 572 a, c dbSNP:757899657
574 574 c, g dbSNP:121912719
576 576 c, g dbSNP:764591376
581 581 a, c, g dbSNP:370526470
582 582 a, g dbSNP:752951478
592 592 c, g dbSNP:387906571
600 600 a, g, t dbSNP:146623682
601 601 c, t dbSNP:751082973
606 606 -, gc dbSNP:781350389
613 613 a, t dbSNP:121912727
623 623 a, g dbSNP:765859780
625 625 c, g, t dbSNP:5078
629 629 c, g dbSNP:143182884
633 633 c, t dbSNP:1052925
636 636 g, t dbSNP:140770089
638 638 c, g dbSNP:558064576
640 640 c, g dbSNP:121912722
648 648 a, g dbSNP:201218000
650 650 c, g dbSNP:772355721
651 651 a, g dbSNP:746067683
656 656 c, g dbSNP:779203966
661 661 a, c dbSNP:771101090
663 663 c, t dbSNP:28931573
664 664 c, g dbSNP:121912728
667 667 c, t dbSNP:121912729
669 669 a, c, g dbSNP:121912730
671 671 c, g dbSNP:778443432
675 675 a, c dbSNP:756535387
676 676 a, g dbSNP:753109330
685 685 c, t dbSNP:781353714
691 691 a, g dbSNP:754715451
692 692 a, g dbSNP:5079
695 695 g, t dbSNP:751207751
708 708 a, g dbSNP:367638050
711 711 c, g dbSNP:762475205
716 716 c, g, t dbSNP:375529707
719 719 a, g dbSNP:199797843
722 722 c, t dbSNP:776551437
725 725 c, t dbSNP:372930229
726 726 c, g dbSNP:1053223
732 732 c, g dbSNP:759880182
736 736 c, g dbSNP:200394039
738 738 a, g dbSNP:121912717
740 740 a, g dbSNP:749406849
744 744 c, t dbSNP:14081
747 747 a, g dbSNP:777929592
752 752 c, g, t dbSNP:748589835
758 758 a, c dbSNP:781667498
759 759 a, g dbSNP:755277427
773 773 c, t dbSNP:536011950
780 780 a, g dbSNP:779713741
787 787 -, tcc dbSNP:768847919
787 787 c, t dbSNP:757980533
794 794 a, g dbSNP:773009729
798 798 a, c dbSNP:368503162
800 800 c, g dbSNP:567268961
801 801 c, g dbSNP:757288749
806 806 c, g dbSNP:5080
809 809 c, g dbSNP:763996092
823 823 a, g dbSNP:555795338
826 826 a, t dbSNP:760566805
835 835 g, t dbSNP:775381241
840 840 a, g dbSNP:766709243
855 855 a, g dbSNP:143430381
868 868 a, g dbSNP:761951364
870 870 -, aca dbSNP:747014491
873 873 c, t dbSNP:763209676
874 874 a, c dbSNP:773399124
881 881 c, t dbSNP:374998745
886 886 a, g dbSNP:748728104
893 893 c, t dbSNP:777027692
895 895 c, t dbSNP:370532459
897 897 a, c, g, t dbSNP:187335584
898 898 c, g, t dbSNP:374923795
900 900 -, t dbSNP:778143140
902 902 c, g dbSNP:531513949
905 905 a, g dbSNP:370384954
924 924 c, t dbSNP:763966714
925 925 c, t dbSNP:377370544
926 926 a, c dbSNP:752550293
928 928 a, g dbSNP:767406908
933 933 a, g dbSNP:3178226

Target ORF information:

RefSeq Version XM_005271540
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005271540

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27099
Accession Version NM_000039.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu27099D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product apolipoprotein A-I preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X02162.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02162.1, BC110286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000030.1
CDS39..842
Misc Feature(1)240..839(+)
Misc Feature(2)312..812(+)
Misc Feature(3)366..368(+)
Misc Feature(4)444..446(+)
Exon (1)1..18
Gene:APOA1
Gene Synonym:
Exon (2)19..81
Gene:APOA1
Gene Synonym:
Exon (3)82..238
Gene:APOA1
Gene Synonym:
Exon (4)239..897
Gene:APOA1
Gene Synonym:
Translation
Position Chain Variation Link
4 4 a, g dbSNP:563005045
9 9 c, t dbSNP:543422728
27 27 c, t dbSNP:781068686
28 28 a, g dbSNP:199729971
47 47 c, t dbSNP:141383703
50 50 a, g dbSNP:368534370
65 65 c, t dbSNP:758732160
66 66 a, g dbSNP:750125257
68 68 a, g dbSNP:762675498
79 79 c, t dbSNP:778560581
80 80 a, g dbSNP:760255146
93 93 c, t dbSNP:371084971
94 94 c, g dbSNP:777407596
95 95 a, g, t dbSNP:571564084
105 105 c, t dbSNP:387906570
117 117 a, c, t dbSNP:200213347
118 118 a, c, g dbSNP:121912720
120 120 c, t dbSNP:751415951
121 121 c, g dbSNP:121912721
122 122 c, t dbSNP:369066087
123 123 -, c dbSNP:753348565
125 125 c, g dbSNP:751028421
126 126 a, g dbSNP:147246779
128 128 c, t dbSNP:563067047
129 129 c, g dbSNP:764283540
139 139 g, t dbSNP:28929476
146 146 a, g dbSNP:775510323
150 150 -, c dbSNP:768017979
150 150 c, t dbSNP:745889664
152 152 c, g dbSNP:772574430
154 154 c, t dbSNP:746314593
156 156 a, g dbSNP:774753857
158 158 g, t dbSNP:771194289
159 159 g, t dbSNP:201148448
165 165 a, c, g dbSNP:373545875
170 170 a, t dbSNP:755740688
176 176 c, t dbSNP:747688781
183 183 a, c dbSNP:780794079
184 184 g, t dbSNP:755026583
185 185 c, t dbSNP:757974682
186 186 a, c, g dbSNP:28931574
191 191 a, g dbSNP:758106382
196 196 a, g dbSNP:750185173
200 200 c, g dbSNP:193922099
204 204 c, t dbSNP:121912725
206 206 a, g dbSNP:760886281
214 214 g, t dbSNP:775559386
216 216 c, g, t dbSNP:199759119
218 218 c, t dbSNP:774804784
219 219 a, g dbSNP:12718465
221 221 c, t dbSNP:5071
223 223 g, t dbSNP:17407917
224 224 a, g dbSNP:763248522
226 226 -, g dbSNP:759977217
233 233 a, g dbSNP:773584936
236 236 a, g dbSNP:540974091
239 239 a, c dbSNP:746552681
248 248 -, cct dbSNP:770007065
249 249 c, g dbSNP:779553097
251 251 g, t dbSNP:565203809
258 258 c, t dbSNP:121912726
266 266 c, t dbSNP:771919707
272 272 c, t dbSNP:745802908
275 275 c, t dbSNP:375453486
279 279 g, t dbSNP:777403379
280 280 a, t dbSNP:757011774
289 289 g, t dbSNP:121912724
290 290 g, t dbSNP:752962410
293 293 a, c dbSNP:757902962
299 299 g, t dbSNP:143796163
302 302 c, g dbSNP:755152208
305 305 a, c dbSNP:751593786
308 308 g, t dbSNP:752390257
313 313 c, t dbSNP:766422306
317 317 a, g dbSNP:763439449
322 322 a, t dbSNP:138407155
325 325 a, g dbSNP:576348564
326 326 g, t dbSNP:201320308
334 334 c, t dbSNP:372520221
339 339 a, g dbSNP:143723530
340 340 a, g dbSNP:17145083
348 348 a, g dbSNP:763847275
350 350 g, t dbSNP:760348365
353 353 c, t dbSNP:148950234
360 360 c, t dbSNP:121912723
362 362 a, g dbSNP:2727787
365 365 a, g dbSNP:113733249
368 368 c, g dbSNP:745829293
377 377 c, g, t dbSNP:150243849
379 379 c, t dbSNP:28931575
394 394 c, t dbSNP:749111893
400 400 c, t dbSNP:777476426
401 401 a, g dbSNP:755205186
410 410 c, g dbSNP:747252682
413 413 g, t dbSNP:780038655
414 414 c, g dbSNP:5077
415 415 a, g dbSNP:758483455
427 427 a, g dbSNP:367866651
429 429 -, aag dbSNP:532489785
429 429 a, t dbSNP:121912716
430 430 a, t dbSNP:4882
439 439 a, g dbSNP:765880276
442 442 a, g dbSNP:757776512
445 445 g, t dbSNP:754271246
455 455 a, c dbSNP:764542484
456 456 c, t dbSNP:760468591
458 458 c, t dbSNP:775173438
463 463 a, g dbSNP:766981019
472 472 c, t dbSNP:373953986
473 473 c, g dbSNP:759104683
474 474 a, c, g, t dbSNP:544524212
491 491 a, g dbSNP:773694724
492 492 a, g dbSNP:574061789
515 515 a, c dbSNP:749164883
516 516 a, c, g dbSNP:121912718
518 518 g, t dbSNP:769548576
521 521 g, t dbSNP:747245248
523 523 a, c dbSNP:780347391
526 526 a, g dbSNP:758509542
530 530 a, c, g dbSNP:141429250
532 532 g, t dbSNP:779081481
536 536 a, c dbSNP:757899657
538 538 c, g dbSNP:121912719
540 540 c, g dbSNP:764591376
545 545 a, c, g dbSNP:370526470
546 546 a, g dbSNP:752951478
556 556 c, g dbSNP:387906571
564 564 a, g, t dbSNP:146623682
565 565 c, t dbSNP:751082973
570 570 -, gc dbSNP:781350389
577 577 a, t dbSNP:121912727
587 587 a, g dbSNP:765859780
589 589 c, g, t dbSNP:5078
593 593 c, g dbSNP:143182884
597 597 c, t dbSNP:1052925
600 600 g, t dbSNP:140770089
602 602 c, g dbSNP:558064576
604 604 c, g dbSNP:121912722
612 612 a, g dbSNP:201218000
614 614 c, g dbSNP:772355721
615 615 a, g dbSNP:746067683
620 620 c, g dbSNP:779203966
625 625 a, c dbSNP:771101090
627 627 c, t dbSNP:28931573
628 628 c, g dbSNP:121912728
631 631 c, t dbSNP:121912729
633 633 a, c, g dbSNP:121912730
635 635 c, g dbSNP:778443432
639 639 a, c dbSNP:756535387
640 640 a, g dbSNP:753109330
649 649 c, t dbSNP:781353714
655 655 a, g dbSNP:754715451
656 656 a, g dbSNP:5079
659 659 g, t dbSNP:751207751
672 672 a, g dbSNP:367638050
675 675 c, g dbSNP:762475205
680 680 c, g, t dbSNP:375529707
683 683 a, g dbSNP:199797843
686 686 c, t dbSNP:776551437
689 689 c, t dbSNP:372930229
690 690 c, g dbSNP:1053223
696 696 c, g dbSNP:759880182
700 700 c, g dbSNP:200394039
702 702 a, g dbSNP:121912717
704 704 a, g dbSNP:749406849
708 708 c, t dbSNP:14081
711 711 a, g dbSNP:777929592
716 716 c, g, t dbSNP:748589835
722 722 a, c dbSNP:781667498
723 723 a, g dbSNP:755277427
737 737 c, t dbSNP:536011950
744 744 a, g dbSNP:779713741
751 751 -, tcc dbSNP:768847919
751 751 c, t dbSNP:757980533
758 758 a, g dbSNP:773009729
762 762 a, c dbSNP:368503162
764 764 c, g dbSNP:567268961
765 765 c, g dbSNP:757288749
770 770 c, g dbSNP:5080
773 773 c, g dbSNP:763996092
787 787 a, g dbSNP:555795338
790 790 a, t dbSNP:760566805
799 799 g, t dbSNP:775381241
804 804 a, g dbSNP:766709243
819 819 a, g dbSNP:143430381
832 832 a, g dbSNP:761951364
834 834 -, aca dbSNP:747014491
837 837 c, t dbSNP:763209676
838 838 a, c dbSNP:773399124
845 845 c, t dbSNP:374998745
850 850 a, g dbSNP:748728104
857 857 c, t dbSNP:777027692
859 859 c, t dbSNP:370532459
861 861 a, c, g, t dbSNP:187335584
862 862 c, g, t dbSNP:374923795
864 864 -, t dbSNP:778143140
866 866 c, g dbSNP:531513949
869 869 a, g dbSNP:370384954
888 888 c, t dbSNP:763966714
889 889 c, t dbSNP:377370544
890 890 a, c dbSNP:752550293
892 892 a, g dbSNP:767406908
897 897 a, g dbSNP:3178226

Target ORF information:

RefSeq Version NM_000039
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein A-I (APOA1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000039

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAAAGCTG CGGTGCTGAC CTTGGCCGTG CTCTTCCTGA CGGGGAGCCA GGCTCGGCAT 
TTCTGGCAGC AAGATGAACC CCCCCAGAGC CCCTGGGATC GAGTGAAGGA CCTGGCCACT
GTGTACGTGG ATGTGCTCAA AGACAGCGGC AGAGACTATG TGTCCCAGTT TGAAGGCTCC
GCCTTGGGAA AACAGCTAAA CCTAAAGCTC CTTGACAACT GGGACAGCGT GACCTCCACC
TTCAGCAAGC TGCGCGAACA GCTCGGCCCT GTGACCCAGG AGTTCTGGGA TAACCTGGAA
AAGGAGACAG AGGGCCTGAG GCAGGAGATG AGCAAGGATC TGGAGGAGGT GAAGGCCAAG
GTGCAGCCCT ACCTGGACGA CTTCCAGAAG AAGTGGCAGG AGGAGATGGA GCTCTACCGC
CAGAAGGTGG AGCCGCTGCG CGCAGAGCTC CAAGAGGGCG CGCGCCAGAA GCTGCACGAG
CTGCAAGAGA AGCTGAGCCC ACTGGGCGAG GAGATGCGCG ACCGCGCGCG CGCCCATGTG
GACGCGCTGC GCACGCATCT GGCCCCCTAC AGCGACGAGC TGCGCCAGCG CTTGGCCGCG
CGCCTTGAGG CTCTCAAGGA GAACGGCGGC GCCAGACTGG CCGAGTACCA CGCCAAGGCC
ACCGAGCATC TGAGCACGCT CAGCGAGAAG GCCAAGCCCG CGCTCGAGGA CCTCCGCCAA
GGCCTGCTGC CCGTGCTGGA GAGCTTCAAG GTCAGCTTCC TGAGCGCTCT CGAGGAGTAC
ACTAAGAAGC TCAACACCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.