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IFNA6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol IFNA6
Entrez Gene ID 3443
Full Name interferon, alpha 6
Synonyms IFN-alphaK
General protein information
Preferred Names
interferon alpha-6
Names
interferon alpha-6
leIF K
IFN-alpha-6
interferon alpha-K
interferon alpha-54
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p22

Summary lac of sum
Disorder MIM:

147566


mRNA and Protein(s)

mRNA Protein Name
NM_021002 NP_066282 interferon alpha-6 precursor

KEGG
hsa04060 Cytokine-cytokine receptor interaction
hsa04650 Natural killer cell mediated cytotoxicity
hsa04140 Regulation of autophagy
hsa04630 Jak-STAT signaling pathway
hsa04620 Toll-like receptor signaling pathway
hsa05320 Autoimmune thyroid disease
hsa04622 RIG-I-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa05160 Hepatitis C
hsa05162 Measles
hsa05152 Tuberculosis
hsa05164 Influenza A
hsa05168 Herpes simplex infection
hsa04151 PI3K-Akt signaling pathway
hsa05161 Hepatitis B
Reactome
R-HSA-168256 Immune System
R-HSA-168249 Innate Immune System
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-913531 Interferon Signaling
R-HSA-109582 Hemostasis
R-HSA-912694 Regulation of IFNA signaling
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
WikiPathways
WP75 Toll-like receptor signaling pathway
WP1449 Regulation of toll-like receptor signaling pathway


Homo sapiens (human) IFNA6 NP_066282.1
Pan troglodytes (chimpanzee) IFNA6 XP_528566.1
Macaca mulatta (Rhesus monkey) LOC710707 XP_001099374.1

Component

ID Name Evidence
GO:0005575 cellular_component ND
GO:0005576 extracellular region EXP
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IEA

Function

ID Name Evidence
GO:0005125 cytokine activity IEA
GO:0005126 cytokine receptor binding NAS

Process

ID Name Evidence
GO:0006952 defense response IEA
GO:0007596 blood coagulation TAS
GO:0009615 response to virus NAS
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0060337 type I interferon-mediated signaling pathway TAS
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IFNA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu32296
NM_021002 Homo sapiens interferon, alpha 6 (IFNA6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu32296
Accession Version NM_021002.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-FEB-2014
Organism Homo sapiens (human)
Product interferon alpha-6 precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL353732.14. On Mar 24, 2010 this sequence version replaced gi:11128014. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069471.1 [ECO:0000345] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCTTTGC CTTTTGCTTT ACTGATGGCC CTGGTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTCTGGACT GTGATCTGCC TCAGACCCAC AGCCTGGGTC ACAGGAGGAC CATGATGCTC
CTGGCACAAA TGAGGAGAAT CTCTCTTTTC TCCTGTCTGA AGGACAGACA TGACTTCAGA
TTTCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTGAAGCCAT CTCTGTCCTC
CATGAGGTGA TTCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGTTGCTTGG
GATGAGAGGC TTCTAGACAA ACTCTATACT GAACTTTACC AGCAGCTGAA TGACCTGGAA
GCCTGTGTGA TGCAGGAGGT GTGGGTGGGA GGGACTCCCC TGATGAATGA GGACTCCATC
CTGGCTGTGA GAAAATACTT CCAAAGAATC ACTCTCTACC TGACAGAGAA AAAGTACAGC
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTC ATCAAGAAAC
TTGCAAGAAA GGTTAAGGAG GAAGGAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_066282.1
CDS1..570
Misc Feature(1)76..534(+)
Misc Feature(2)82..363(+)
Misc Feature(3)157..480(+)
Misc Feature(4)301..303(+)
Exon (1)1..570
Gene:IFNA6
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:199909475
7 7 c, t dbSNP:751594218
8 8 -, t dbSNP:759427612
30 30 c, g dbSNP:763898270
42 42 c, t dbSNP:762661508
48 48 c, t dbSNP:752908789
50 50 a, c dbSNP:765365156
53 53 c, t dbSNP:759825676
56 56 a, g dbSNP:776665055
65 65 c, t dbSNP:150008995
66 66 c, g dbSNP:761125708
69 69 c, g dbSNP:773621151
84 84 a, g dbSNP:114283047
86 86 c, t dbSNP:748471373
101 101 a, c dbSNP:779388589
102 102 c, t dbSNP:769565797
105 105 g, t dbSNP:773491904
112 112 a, g, t dbSNP:780824980
116 116 c, t dbSNP:763506434
134 134 a, g dbSNP:751449334
139 139 a, c, g dbSNP:190705153
141 141 c, t dbSNP:752430395
143 143 c, t dbSNP:765124284
145 145 c, t dbSNP:759736076
146 146 c, t dbSNP:61736254
150 150 a, c, t dbSNP:144160887
152 152 c, g dbSNP:375617147
156 156 c, t dbSNP:61736255
162 162 a, g dbSNP:573657270
169 169 c, t dbSNP:560117253
170 170 a, g dbSNP:372927228
173 173 -, acttca dbSNP:776617474
175 175 c, t dbSNP:774548087
177 177 c, t dbSNP:200999463
178 178 a, g dbSNP:201824804
179 179 a, g dbSNP:781021241
180 180 a, g dbSNP:557998847
186 186 c, t dbSNP:61736257
187 187 a, c, t dbSNP:370196139
188 188 a, c dbSNP:748170034
194 194 a, g dbSNP:778632414
201 201 c, t dbSNP:754801756
203 203 g, t dbSNP:753990267
211 211 c, t dbSNP:766599103
216 216 g, t dbSNP:756382547
218 218 a, c dbSNP:750461778
220 220 c, g dbSNP:767675202
223 223 c, g dbSNP:762204032
224 224 a, c dbSNP:774942376
227 227 a, c dbSNP:764511820
229 229 a, g dbSNP:763424513
240 240 c, t dbSNP:753337075
247 247 g, t dbSNP:141284622
252 252 c, t dbSNP:770702683
253 253 a, c, t dbSNP:112773436
260 260 a, c, t dbSNP:189717919
262 262 c, t dbSNP:369385528
266 266 a, t dbSNP:747999082
267 267 c, t dbSNP:2988573
270 270 c, t dbSNP:754707601
280 280 a, g dbSNP:776294975
283 283 a, g dbSNP:186416653
284 284 a, g dbSNP:76096785
285 285 c, t dbSNP:375649668
292 292 a, g dbSNP:147415542
298 298 c, t dbSNP:570503239
303 303 -, t dbSNP:770677886
306 306 a, g dbSNP:757387079
308 308 a, g dbSNP:752045218
310 310 c, t dbSNP:142796435
325 325 a, t dbSNP:763624127
326 326 a, t dbSNP:775965956
330 330 g, t dbSNP:765747625
346 346 c, t dbSNP:531897763
354 354 c, t dbSNP:772951080
355 355 c, t dbSNP:771419152
365 365 c, g dbSNP:747703612
367 367 a, g dbSNP:773906390
383 383 a, g dbSNP:768572559
384 384 a, g dbSNP:749260722
385 385 a, g dbSNP:137921767
387 387 a, g dbSNP:771878044
389 389 a, c, g dbSNP:372401225
392 392 g, t dbSNP:781479577
393 393 -, g dbSNP:746726590
398 398 c, t dbSNP:757480310
399 399 c, g dbSNP:370092473
400 400 c, t dbSNP:61736258
402 402 a, g dbSNP:758952540
411 411 a, g dbSNP:141102746
416 416 -, tgagaaaata dbSNP:777410972
416 416 c, g dbSNP:753282137
418 418 a, t dbSNP:765482737
424 424 a, g dbSNP:759952915
435 435 a, g dbSNP:749989935
445 445 a, t dbSNP:767180943
446 446 g, t dbSNP:549218066
452 452 a, c, t dbSNP:560876373
454 454 c, g dbSNP:560453521
457 457 c, t dbSNP:751973648
464 464 a, c dbSNP:202179791
471 471 a, g dbSNP:769407762
474 474 a, c, g dbSNP:780917224
483 483 c, t dbSNP:771153703
487 487 g, t dbSNP:747286229
489 489 a, c dbSNP:777952151
490 490 c, t dbSNP:758585517
497 497 c, g, t dbSNP:138969995
505 505 a, g dbSNP:779491725
509 509 a, c dbSNP:150269404
521 521 c, g dbSNP:200866459
529 529 c, t dbSNP:766691699
535 535 a, g dbSNP:761429957
544 544 a, c dbSNP:370874088
550 550 -, a dbSNP:771498771
552 552 g, t dbSNP:577977593
555 555 a, g dbSNP:777793304
565 565 a, g dbSNP:762454870
567 567 a, g dbSNP:141069504
569 569 a, g dbSNP:769767761

Target ORF information:

RefSeq Version NM_021002
Organism Homo sapiens (human)
Definition Homo sapiens interferon, alpha 6 (IFNA6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021002

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCTTTGC CTTTTGCTTT ACTGATGGCC CTGGTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTCTGGACT GTGATCTGCC TCAGACCCAC AGCCTGGGTC ACAGGAGGAC CATGATGCTC
CTGGCACAAA TGAGGAGAAT CTCTCTTTTC TCCTGTCTGA AGGACAGACA TGACTTCAGA
TTTCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTGAAGCCAT CTCTGTCCTC
CATGAGGTGA TTCAGCAGAC CTTCAACCTC TTCAGCACAA AGGACTCATC TGTTGCTTGG
GATGAGAGGC TTCTAGACAA ACTCTATACT GAACTTTACC AGCAGCTGAA TGACCTGGAA
GCCTGTGTGA TGCAGGAGGT GTGGGTGGGA GGGACTCCCC TGATGAATGA GGACTCCATC
CTGGCTGTGA GAAAATACTT CCAAAGAATC ACTCTCTACC TGACAGAGAA AAAGTACAGC
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTC ATCAAGAAAC
TTGCAAGAAA GGTTAAGGAG GAAGGAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
Fam. Cancer 9 (4), 625-633 (2010)
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA and Goldstein AM.


book

Dengue hemorrhagic fever is associated with polymorphisms in JAK1
Eur. J. Hum. Genet. 18 (11), 1221-1227 (2010)
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG and Teixeira MG.


book

Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls
Pediatr. Pulmonol. 45 (6), 608-613 (2010)
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL and Janssen R.


book

Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus
J. Infect. Dis. 201 (9), 1371-1380 (2010)
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL and Thio CL.


book

New genetic associations detected in a host response study to hepatitis B vaccine
Genes Immun. 11 (3), 232-238 (2010)
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML and Seielstad M.


book

Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes
Biochem. J. 329 (PT 2), 295-302 (1998)
Nyman TA, Tolo H, Parkkinen J and Kalkkinen N.


book

Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest
Mol. Cell. Biol. 16 (7), 3934-3944 (1996)
Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI and Kimchi A.


book

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
Cell 76 (5), 821-828 (1994)
Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D and Darnell JE Jr.


book

Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
Genomics 14 (2), 437-443 (1992)
Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM and Diaz MO.


book

Structural relationship of human interferon alpha genes and pseudogenes
J. Mol. Biol. 185 (2), 227-260 (1985)
Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R., Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.


 
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