The following MACC1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MACC1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||Documents for ORF clone product in dufault vector
||ORF Nucleotide Sequence (Length: 2559bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||metastasis-associated in colon cancer protein 1
||VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK131400.1, AJ313524.1, AC007001.2 and CB240872.1.
On Sep 25, 2007 this sequence version replaced gi:47271497.
Summary: MACC1 is a key regulator of the hepatocyte growth factor
(HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway,
which is involved in cellular growth, epithelial-mesenchymal
transition, angiogenesis, cell motility, invasiveness, and
metastasis. Expression of MACC1 in colon cancer (MIM 114500)
specimens is an independent prognostic indicator for metastasis
formation and metastasis-free survival (Stein et al., 2009 [PubMed
19098908]).[supplied by OMIM, Mar 2009].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK131400.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.