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MACC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MACC1
Entrez Gene ID 346389
Full Name metastasis associated in colon cancer 1
Synonyms 7A5, SH3BP4L
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p21.1

Summary MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]. lac of sum
Disorder MIM:

612646


mRNA and Protein(s)

mRNA Protein Name
NM_182762 NP_877439 metastasis-associated in colon cancer protein 1


Homo sapiens (human) MACC1 NP_877439.3
Pan troglodytes (chimpanzee) MACC1 XP_003318388.1
Canis lupus familiaris (dog) MACC1 XP_005628662.1
Bos taurus (cattle) MACC1 XP_002686732.1
Mus musculus (house mouse) Macc1 NP_001156608.1
Rattus norvegicus (Norway rat) Macc1 NP_001178704.1
Gallus gallus (chicken) MACC1 XP_418705.4
Danio rerio (zebrafish) macc1 NP_001186695.1
Xenopus (Silurana) tropicalis (western clawed frog) macc1 XP_002933345.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MACC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MACC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20050 NM_182762 Homo sapiens metastasis associated in colon cancer 1 (MACC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $475.30
$679.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20050
Clone ID Related Accession (Same CDS sequence) NM_182762
Accession Version NM_182762.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2559bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product metastasis-associated in colon cancer protein 1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK131400.1, AJ313524.1, AC007001.2 and CB240872.1. On Sep 25, 2007 this sequence version replaced gi:47271497. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131400.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
ATGCTAATCA CTGAAAGAAA ACATTTTCGG TCAGGAAGAA TTGCACAAAG TATGTCTGAA 
GCAAATTTGA TTGACATGGA AGCTGGAAAA CTCTCAAAAA GTTGCAATAT TACAGAATGC
CAGGACCCAG ACTTGCTTCA CAATTGGCCG GATGCTTTCA CCCTTCGTGG TAATAATGCT
TCCAAAGTTG CAAATCCATT CTGGAATCAA CTGTCTGCTT CTAACCCATT TTTGGATGAC
ATAACTCAAC TAAGAAATAA CAGGAAGAGA AATAATATTT CCATCTTAAA GGAAGATCCT
TTTCTTTTCT GTAGAGAAAT AGAAAATGGA AATTCTTTTG ATTCCTCCGG TGATGAACTT
GATGTGCATC AGTTACTTAG GCAGACTTCC TCAAGAAATT CTGGAAGATC TAAAAGTGTT
TCAGAACTTC TGGACATTTT AGACGACACA GCACATGCCC ATCAGAGTAT ACATAACTCT
GACCAGATCC TACTACACGA CTTAGAGTGG CTTAAAAATG ATCGGGAGGC TTATAAAATG
GCTTGGTTAA GTCAACGCCA GCTGGCCCGC TCCTGCCTTG ATTTGAATAC AATTAGTCAG
AGCCCTGGAT GGGCCCAGAC ACAACTTGCG GAGGTCACCA TAGCTTGCAA AGTAAACCAT
CAAGGAGGGT CAGTACAATT ACCTGAATCA GACATCACTG TTCATGTGCC CCAAGGTCAT
GTGGCTGTGG GAGAATTCCA AGAGGTGTCT CTAAGGGCTT TCCTTGATCC GCCACACATG
CTTAACCATG ATCTTTCGTG CACTGTGAGC CCGTTGTTGG AAATCATGTT AGGCAACCTC
AATACAATGG AAGCCCTTTT GCTGGAGATG AAAATTGGGG CTGAAGTAAG AAAGGATCCT
TTCAGCCAAG TCATGACAGA AATGGTGTGT TTACACAGCT TGGGTAAAGA AGGCCCTTTT
AAAGTTTTAA GCAACTGCTA CATTTATAAA GACACCATCC AAGTCAAGCT AATCGACTTG
AGTCAGGTAA TGTATCTAGT GGTTGCTGCA CAAGCTAAAG CTCTTCCGTC ACCAGCTGCC
ACCATTTGGG ATTATATCCA CAAAACCACC TCAATTGGAA TTTATGGACC CAAATATATC
CATCCCAGTT TTACTGTTGT TTTAACAGTT TGTGGACACA ATTATATGCC AGGACAGCTT
ACAATTTCTG ATATTAAGAA GGGTGGAAAA AACATATCTC CAGTTGTGTT TCAGCTCTGG
GGGAAGCAGT CATTTTTACT TGACAAGCCA CAAGATTTAA GTATTTCTAT TTTTTCCTGT
GATCCTGATT TTGAAGTAAA GACAGAAGGA GAAAGGAAAG AAATTAAACA AAAGCAGTTG
GAAGCAGGTG AAGTAGTTCA TCAACAATTT TTATTTTCTT TAGTTGAGCA CAGAGAGATG
CACTTGTTTG ATTTTTGTGT TCAAGTGGAG CCTCCCAATG GTGAACCAGT TGCACAGTTC
TCTATCACTA CTCCTGATCC AACCCCAAAC CTAAAAAGAC TCTCGAATCT GCCAGGCTAT
TTGCAGAAGA AGGAGGAAAT CAAGTCTGCT CCTTTATCAC CAAAAATTCT TGTTAAATAT
CCTACATTTC AAGATAAAAC ATTGAACTTT AGCAACTATG GGGTAACCCT GAAGGCAGTG
CTAAGACAAA GCAAGATTGA TTACTTCCTT GAATATTTCA AAGGGGACAC AATAGCTCTC
CTCGGGGAAG GTAAGGTAAA AGCTATTGGT CAGTCCAAAG TGAAAGAATG GTATGTAGGA
GTCCTCAGAG GTAAGATTGG ACTTGTACAC TGCAAAAATG TCAAGGTGAT TTCAAAGGAG
CAAGTAATGT TTATGTCAGA TAGTGTCTTT ACAACCAGAA ATCTTCTTGA ACAGATTGTC
CTGCCTTTAA AAAAATTGAC TTATATCTAC TCAGTTGTAT TAACCTTGGT GTCAGAAAAA
GTTTATGATT GGAAAGTTTT AGCTGATGTC CTGGGTTACT CACATCTGTC CCTGGAAGAT
TTTGATCAAA TTCAAGCAGA CAAAGAATCA GAGAAAGTTT CTTATGTTAT AAAGAAGTTA
AAGGAAGATT GCCACACAGA GAGAAATACA AGGAAGTTTC TGTATGAACT TATTGTGGCT
CTTCTGAAAA TGGATTGCCA AGAGTTAGTC GCACGTCTCA TCCAAGAAGC TGCTGTTCTG
ACTTCAGCTG TCAAGCTTGG AAAAGGCTGG AGGGAACTAG CTGAAAAGTT AGTACGACTC
ACAAAGCAAC AAATGGAGGC ATATGAAATT CCTCATCGAG GAAACACTGG AGATGTTGCT
GTTGAGATGA TGTGGAAACC TGCCTATGAT TTTCTGTATA CCTGGAGTGC TCACTATGGA
AATAACTACA GAGATGTGTT ACAAGACCTT CAGTCAGCTT TGGACAGAAT GAAAAACCCT
GTGACTAAAC ACTGGAGAGA ATTAACTGGA GTTTTAATAC TAGTAAATTC TTTGGAGGTT
TTGAGAGTAA CTGCATTCTC CACTTCTGAG GAAGTATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_877439.3
CDS310..2868
Misc Feature(1)262..264(+)
Misc Feature(2)2365..>2601(+)
Misc Feature(3)2536..2763(+)
Exon (1)1..92
Gene:MACC1
Gene Synonym:
Exon (2)93..157
Gene:MACC1
Gene Synonym:
Exon (3)158..301
Gene:MACC1
Gene Synonym:
Exon (4)302..424
Gene:MACC1
Gene Synonym:
Exon (5)425..2466
Gene:MACC1
Gene Synonym:
Exon (6)2467..2655
Gene:MACC1
Gene Synonym:
Exon (7)2656..9159
Gene:MACC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_182762
Organism Homo sapiens (human)
Definition Homo sapiens metastasis associated in colon cancer 1 (MACC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_182762

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
ATGCTAATCA CTGAAAGAAA ACATTTTCGG TCAGGAAGAA TTGCACAAAG TATGTCTGAA 
GCAAATTTGA TTGACATGGA AGCTGGAAAA CTCTCAAAAA GTTGCAATAT TACAGAATGC
CAGGACCCAG ACTTGCTTCA CAATTGGCCG GATGCTTTCA CCCTTCGTGG TAATAATGCT
TCCAAAGTTG CAAATCCATT CTGGAATCAA CTGTCTGCTT CTAACCCATT TTTGGATGAC
ATAACTCAAC TAAGAAATAA CAGGAAGAGA AATAATATTT CCATCTTAAA GGAAGATCCT
TTTCTTTTCT GTAGAGAAAT AGAAAATGGA AATTCTTTTG ATTCCTCCGG TGATGAACTT
GATGTGCATC AGTTACTTAG GCAGACTTCC TCAAGAAATT CTGGAAGATC TAAAAGTGTT
TCAGAACTTC TGGACATTTT AGACGACACA GCACATGCCC ATCAGAGTAT ACATAACTCT
GACCAGATCC TACTACACGA CTTAGAGTGG CTTAAAAATG ATCGGGAGGC TTATAAAATG
GCTTGGTTAA GTCAACGCCA GCTGGCCCGC TCCTGCCTTG ATTTGAATAC AATTAGTCAG
AGCCCTGGAT GGGCCCAGAC ACAACTTGCG GAGGTCACCA TAGCTTGCAA AGTAAACCAT
CAAGGAGGGT CAGTACAATT ACCTGAATCA GACATCACTG TTCATGTGCC CCAAGGTCAT
GTGGCTGTGG GAGAATTCCA AGAGGTGTCT CTAAGGGCTT TCCTTGATCC GCCACACATG
CTTAACCATG ATCTTTCGTG CACTGTGAGC CCGTTGTTGG AAATCATGTT AGGCAACCTC
AATACAATGG AAGCCCTTTT GCTGGAGATG AAAATTGGGG CTGAAGTAAG AAAGGATCCT
TTCAGCCAAG TCATGACAGA AATGGTGTGT TTACACAGCT TGGGTAAAGA AGGCCCTTTT
AAAGTTTTAA GCAACTGCTA CATTTATAAA GACACCATCC AAGTCAAGCT AATCGACTTG
AGTCAGGTAA TGTATCTAGT GGTTGCTGCA CAAGCTAAAG CTCTTCCGTC ACCAGCTGCC
ACCATTTGGG ATTATATCCA CAAAACCACC TCAATTGGAA TTTATGGACC CAAATATATC
CATCCCAGTT TTACTGTTGT TTTAACAGTT TGTGGACACA ATTATATGCC AGGACAGCTT
ACAATTTCTG ATATTAAGAA GGGTGGAAAA AACATATCTC CAGTTGTGTT TCAGCTCTGG
GGGAAGCAGT CATTTTTACT TGACAAGCCA CAAGATTTAA GTATTTCTAT TTTTTCCTGT
GATCCTGATT TTGAAGTAAA GACAGAAGGA GAAAGGAAAG AAATTAAACA AAAGCAGTTG
GAAGCAGGTG AAGTAGTTCA TCAACAATTT TTATTTTCTT TAGTTGAGCA CAGAGAGATG
CACTTGTTTG ATTTTTGTGT TCAAGTGGAG CCTCCCAATG GTGAACCAGT TGCACAGTTC
TCTATCACTA CTCCTGATCC AACCCCAAAC CTAAAAAGAC TCTCGAATCT GCCAGGCTAT
TTGCAGAAGA AGGAGGAAAT CAAGTCTGCT CCTTTATCAC CAAAAATTCT TGTTAAATAT
CCTACATTTC AAGATAAAAC ATTGAACTTT AGCAACTATG GGGTAACCCT GAAGGCAGTG
CTAAGACAAA GCAAGATTGA TTACTTCCTT GAATATTTCA AAGGGGACAC AATAGCTCTC
CTCGGGGAAG GTAAGGTAAA AGCTATTGGT CAGTCCAAAG TGAAAGAATG GTATGTAGGA
GTCCTCAGAG GTAAGATTGG ACTTGTACAC TGCAAAAATG TCAAGGTGAT TTCAAAGGAG
CAAGTAATGT TTATGTCAGA TAGTGTCTTT ACAACCAGAA ATCTTCTTGA ACAGATTGTC
CTGCCTTTAA AAAAATTGAC TTATATCTAC TCAGTTGTAT TAACCTTGGT GTCAGAAAAA
GTTTATGATT GGAAAGTTTT AGCTGATGTC CTGGGTTACT CACATCTGTC CCTGGAAGAT
TTTGATCAAA TTCAAGCAGA CAAAGAATCA GAGAAAGTTT CTTATGTTAT AAAGAAGTTA
AAGGAAGATT GCCACACAGA GAGAAATACA AGGAAGTTTC TGTATGAACT TATTGTGGCT
CTTCTGAAAA TGGATTGCCA AGAGTTAGTC GCACGTCTCA TCCAAGAAGC TGCTGTTCTG
ACTTCAGCTG TCAAGCTTGG AAAAGGCTGG AGGGAACTAG CTGAAAAGTT AGTACGACTC
ACAAAGCAAC AAATGGAGGC ATATGAAATT CCTCATCGAG GAAACACTGG AGATGTTGCT
GTTGAGATGA TGTGGAAACC TGCCTATGAT TTTCTGTATA CCTGGAGTGC TCACTATGGA
AATAACTACA GAGATGTGTT ACAAGACCTT CAGTCAGCTT TGGACAGAAT GAAAAACCCT
GTGACTAAAC ACTGGAGAGA ATTAACTGGA GTTTTAATAC TAGTAAATTC TTTGGAGGTT
TTGAGAGTAA CTGCATTCTC CACTTCTGAG GAAGTATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

High expression of MACC1 predicts poor prognosis in patients with osteosarcoma
Tumour Biol. 35 (2), 1343-1350 (2014)
Zhang K, Zhang Y, Zhu H, Xue N, Liu J, Shan C and Zhu Q.


book

Overexpression of MACC1 protein and its clinical implications in patients with glioma
Tumour Biol. 35 (1), 815-819 (2014)
Yang T, Kong B, Kuang YQ, Cheng L, Gu JW, Zhang JH, Shu HF, Yu SX, He WQ, Xing XM and Huang HD.


book

MACC1 is related to colorectal cancer initiation and early-stage invasive growth
Am. J. Clin. Pathol. 140 (5), 701-707 (2013)
Ren B, Zakharov V, Yang Q, McMahon L, Yu J and Cao W.


book

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases
Ann. Surg. 257 (6), 1089-1095 (2013)
Isella C, Mellano A, Galimi F, Petti C, Capussotti L, De Simone M, Bertotti A, Medico E and Muratore A.


book

MACC1 as a prognostic biomarker for early-stage and AFP-normal hepatocellular carcinoma
PLoS ONE 8 (5), E64235 (2013)
Xie C, Wu J, Yun J, Lai J, Yuan Y, Gao Z, Li M, Li J and Song L.


book

MACC1 - more than metastasis? Facts and predictions about a novel gene
J. Mol. Med. 88 (1), 11-18 (2010)
Stein U, Dahlmann M and Walther W.


book

MACC1 controls Met: what a difference an Sp1 site makes
Cell Cycle 8 (15), 2467-2469 (2009)
Stein,U., Smith,J., Walther,W. and Arlt,F.


book

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Nat. Med. 15 (1), 59-67 (2009)
Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W and Schlag PM.


book

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
BMC Immunol. 10, 53 (2009)
Voss M, Lettau M and Janssen O.


book

Unexpected domain composition of MACC1 links MET signaling and apoptosis
Acta Biochim. Pol. 56 (2), 317-323 (2009)
Kokoszynska K, Krynski J, Rychlewski L and Wyrwicz LS.


 
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