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APP amyloid beta (A4) precursor protein [Homo sapiens (human)]

Gene Symbol APP
Entrez Gene ID 351
Full Name amyloid beta (A4) precursor protein
Synonyms AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
General protein information
Preferred Names
amyloid beta A4 protein
Names
amyloid beta A4 protein
preA4
protease nexin-II
peptidase nexin-II
beta-amyloid peptide
alzheimer disease amyloid protein
cerebral vascular amyloid peptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q21.3

Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. lac of sum
Disorder MIM:

104760

Disorder Html: Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic





The following APP gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APP gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27229 NM_001204301 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price
OHu27130 NM_001136016 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price
OHu27184 NM_001136131 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$440.3
$629
OHu27406 NM_001136130 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price
OHu27126 NM_001136129 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 Quote Price
OHu27259 NM_000484 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$391.3
$559
OHu26762 NM_201413 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.3
$379
OHu26689 NM_201414 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$489.3
$699
OHu27201 NM_001204302 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price
OHu27287 NM_001204303 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27229
Accession Version NM_001204301.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2259bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform h precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AK294534.1, AK312326.1, Y00264.1 and BM876312.1. Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (h, also known as L-APP752) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: PMID: 1429732 Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGG TTCTGGGTTG
ACAAATATCA AGACGGAGGA GATCTCTGAA GTGAAGATGG ATGCAGAATT CCGACATGAC
TCAGGATATG AAGTTCATCA TCAAAAATTG GTGTTCTTTG CAGAAGATGT GGGTTCAAAC
AAAGGTGCAA TCATTGGACT CATGGTGGGC GGTGTTGTCA TAGCGACAGT GATCGTCATC
ACCTTGGTGA TGCTGAAGAA GAAACAGTAC ACATCCATTC ATCATGGTGT GGTGGAGGTT
GACGCCGCTG TCACCCCAGA GGAGCGCCAC CTGTCCAAGA TGCAGCAGAA CGGCTACGAA
AATCCAACCT ACAAGTTCTT TGAGCAGATG CAGAACTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001191230.1
CDS201..2459
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)594..764(+)
Misc Feature(5)1083..1226(+)
Misc Feature(6)1095..1115(+)
Misc Feature(7)1293..1847(+)
Misc Feature(8)2160..2285(+)
Misc Feature(9)2289..2444(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1233
Gene:APP
Gene Synonym:
Exon (8)1234..1290
Gene:APP
Gene Synonym:
Exon (9)1291..1424
Gene:APP
Gene Synonym:
Exon (10)1425..1499
Gene:APP
Gene Synonym:
Exon (11)1500..1658
Gene:APP
Gene Synonym:
Exon (12)1659..1787
Gene:APP
Gene Synonym:
Exon (13)1788..1887
Gene:APP
Gene Synonym:
Exon (14)1888..2109
Gene:APP
Gene Synonym:
Exon (15)2110..2210
Gene:APP
Gene Synonym:
Exon (16)2211..2357
Gene:APP
Gene Synonym:
Exon (17)2358..3579
Gene:APP
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:200621906
2 2 a, g dbSNP:761755102
20 20 a, g dbSNP:558863815
30 30 a, c dbSNP:199610454
31 31 c, t dbSNP:538664273
34 34 c, t dbSNP:751341076
41 41 c, t dbSNP:145958140
45 45 c, g dbSNP:45476095
53 53 c, t dbSNP:536423638
66 66 a, c dbSNP:567551375
78 78 c, g dbSNP:200990709
90 90 c, g dbSNP:459543
107 107 c, t dbSNP:201528959
130 130 c, t dbSNP:531158286
152 152 c, t dbSNP:779238120
157 157 c, t dbSNP:200289921
177 177 c, g dbSNP:199527632
186 186 c, g dbSNP:754084577
187 187 c, g dbSNP:201509588
190 190 g, t dbSNP:200339053
219 219 c, g dbSNP:767211549
233 233 c, t dbSNP:754674097
242 242 c, g dbSNP:751156099
246 246 c, t dbSNP:202070273
249 249 a, g dbSNP:762505107
258 258 a, g dbSNP:140350218
263 263 a, c dbSNP:765279960
264 264 a, t dbSNP:761648158
265 265 c, g dbSNP:776525030
277 277 c, g dbSNP:763852444
289 289 c, g dbSNP:55979514
296 296 a, c dbSNP:760410401
311 311 c, t dbSNP:55850639
317 317 a, c dbSNP:540353454
319 319 a, g dbSNP:772213572
326 326 c, t dbSNP:745974049
330 330 c, t dbSNP:774281569
333 333 a, c dbSNP:771509390
341 341 c, t dbSNP:200069013
352 352 a, g dbSNP:749737592
353 353 g, t dbSNP:529782627
361 361 c, t dbSNP:56111408
371 371 a, g dbSNP:770316027
374 374 c, g dbSNP:748459651
376 376 c, t dbSNP:779869655
382 382 c, t dbSNP:11549661
383 383 c, g dbSNP:757977578
386 386 c, t dbSNP:201970902
387 387 a, g dbSNP:779329120
388 388 c, t dbSNP:200648330
396 396 a, g dbSNP:778250646
408 408 a, c dbSNP:11549662
412 412 a, g dbSNP:757264249
421 421 a, t dbSNP:753737986
426 426 a, c, g dbSNP:151188448
432 432 c, t dbSNP:770493889
440 440 g, t dbSNP:762382518
443 443 -, gatcac dbSNP:781218975
451 451 a, g dbSNP:777179682
456 456 a, g dbSNP:768921158
471 471 c, t dbSNP:747355134
498 498 c, t dbSNP:200347552
499 499 a, c, g dbSNP:199741007
502 502 a, g dbSNP:532382285
505 505 a, g dbSNP:777260127
512 512 a, g dbSNP:370274393
527 527 c, g dbSNP:748106962
530 530 a, c dbSNP:202145222
536 536 c, g dbSNP:781145038
551 551 c, t dbSNP:201537751
555 555 g, t dbSNP:754736666
559 559 c, g dbSNP:759854517
575 575 c, t dbSNP:142154215
578 578 c, t dbSNP:200826437
584 584 c, t dbSNP:148699407
585 585 a, g, t dbSNP:563647959
595 595 a, c dbSNP:761373193
601 601 a, g dbSNP:576712021
602 602 a, g dbSNP:768518732
616 616 a, t dbSNP:746947550
617 617 a, g dbSNP:779803206
619 619 c, g dbSNP:772020679
621 621 a, g dbSNP:200086074
622 622 a, t dbSNP:745588837
625 625 a, g dbSNP:779288025
626 626 c, t dbSNP:201724614
627 627 a, g dbSNP:200541360
629 629 c, t dbSNP:774664312
632 632 c, t dbSNP:199520480
633 633 a, g dbSNP:201573490
646 646 a, g dbSNP:200857049
653 653 c, t dbSNP:41276552
654 654 a, g dbSNP:756629390
656 656 c, t dbSNP:199591984
657 657 a, g dbSNP:201454946
659 659 c, t dbSNP:766601977
662 662 c, t dbSNP:200398369
671 671 a, g dbSNP:778848481
673 673 a, g dbSNP:771319862
678 678 a, g dbSNP:375376201
682 682 a, g dbSNP:200892475
685 685 a, g dbSNP:200117824
687 687 a, t dbSNP:749504313
689 689 c, t dbSNP:777809878
696 696 c, t dbSNP:201885206
704 704 c, t dbSNP:752661056
705 705 a, g dbSNP:201102339
710 710 a, g dbSNP:372642708
713 713 a, g dbSNP:751958426
722 722 c, t dbSNP:199905579
723 723 a, g dbSNP:201817335
733 733 a, t dbSNP:758637653
738 738 c, t dbSNP:753562272
739 739 a, g, t dbSNP:200898059
744 744 a, g dbSNP:202108340
745 745 c, t dbSNP:771317418
752 752 g, t dbSNP:760249418
762 762 c, t dbSNP:199744129
764 764 a, g dbSNP:775129285
767 767 c, g dbSNP:767631864
774 774 a, g dbSNP:759517529
781 781 a, g dbSNP:201460828
792 792 c, t dbSNP:145081708
802 802 c, t dbSNP:149995579
803 803 a, g dbSNP:368927918
817 817 c, t dbSNP:376138420
818 818 a, g dbSNP:201022619
824 824 c, g dbSNP:748325243
832 832 c, g dbSNP:781215285
834 834 a, g dbSNP:755525590
850 850 a, c dbSNP:747532838
853 853 a, c, g dbSNP:201250681
859 859 c, g dbSNP:200283638
862 862 a, g dbSNP:746717165
872 872 a, g, t dbSNP:200543884
874 874 c, t dbSNP:746313873
878 878 a, g dbSNP:779117377
882 882 a, g dbSNP:755841034
893 893 a, g dbSNP:752421353
904 904 c, t dbSNP:139819006
910 910 g, t dbSNP:201093867
911 911 a, g dbSNP:770301922
918 918 a, g dbSNP:751100831
921 921 a, g dbSNP:766405770
922 922 -, aag dbSNP:755788810
924 924 -, aag dbSNP:754150568
925 925 c, t dbSNP:762765836
926 926 c, t dbSNP:200270161
927 927 a, g dbSNP:750279232
935 935 -, cgaggacga dbSNP:756282934
935 935 c, t dbSNP:201941279
936 936 a, g dbSNP:147485129
941 941 c, t dbSNP:148832151
942 942 a, g dbSNP:200103591
943 943 a, g dbSNP:768813608
945 945 c, g dbSNP:760805196
952 952 a, g dbSNP:775431597
960 960 a, g dbSNP:532114068
964 964 a, g dbSNP:746341405
981 981 c, t dbSNP:201732035
984 984 c, t dbSNP:779428437
986 986 c, t dbSNP:140941257
987 987 a, g dbSNP:201094604
988 988 a, c dbSNP:781049584
993 993 a, g dbSNP:754672142
994 994 c, t dbSNP:751120313
1006 1006 c, t dbSNP:779407819
1012 1012 c, g dbSNP:757873970
1019 1019 -, gcc dbSNP:750896095
1020 1020 a, g dbSNP:200159151
1025 1025 a, c, t dbSNP:765151011
1026 1026 a, g, t dbSNP:202198008
1028 1028 -, cccc dbSNP:147067229
1028 1028 a, c, g dbSNP:777163427
1029 1029 a, c dbSNP:149353279
1031 1031 -, caccaccac dbSNP:768084853
1034 1034 -, caccac dbSNP:762288013
1037 1037 -, cac dbSNP:764406483
1039 1039 -, cac dbSNP:527890624
1043 1043 a, g dbSNP:775689062
1047 1047 c, g dbSNP:772069024
1056 1056 a, g dbSNP:200620364
1061 1061 g, t dbSNP:759620674
1070 1070 g, t dbSNP:755866188
1076 1076 c, t dbSNP:752479913
1077 1077 g, t dbSNP:767698341
1085 1085 c, t dbSNP:199890425
1086 1086 a, g dbSNP:751737009
1090 1090 c, t dbSNP:557227002
1091 1091 a, g, t dbSNP:773857944
1094 1094 a, g dbSNP:765778316
1096 1096 c, t dbSNP:202074408
1097 1097 a, c, g dbSNP:201294669
1101 1101 c, t dbSNP:771666332
1102 1102 a, g dbSNP:539326715
1107 1107 a, g dbSNP:773947319
1110 1110 a, g dbSNP:200539466
1117 1117 a, g, t dbSNP:202218688
1128 1128 a, g dbSNP:777701309
1131 1131 a, g dbSNP:769757835
1133 1133 g, t dbSNP:373259666
1140 1140 a, g dbSNP:747933636
1148 1148 c, t dbSNP:781018195
1149 1149 g, t dbSNP:754679397
1150 1150 a, c dbSNP:751861230
1163 1163 c, t dbSNP:150676543
1166 1166 c, t dbSNP:200016837
1167 1167 a, g dbSNP:750513875
1169 1169 a, t dbSNP:765734593
1175 1175 c, t dbSNP:201622977
1176 1176 a, g dbSNP:754207226
1177 1177 -, g dbSNP:141526793
1182 1182 c, t dbSNP:200978018
1183 1183 a, g dbSNP:370414043
1195 1195 a, g dbSNP:773998162
1197 1197 a, g dbSNP:770513095
1204 1204 a, c dbSNP:762508225
1208 1208 c, t dbSNP:772676633
1212 1212 a, g dbSNP:200074159
1216 1216 c, t dbSNP:373234317
1217 1217 c, t dbSNP:201462552
1218 1218 a, g dbSNP:768499633
1221 1221 g, t dbSNP:746740645
1224 1224 a, g dbSNP:200727285
1226 1226 c, t dbSNP:199824159
1229 1229 c, t dbSNP:750575150
1230 1230 a, g dbSNP:201045185
1232 1232 c, t dbSNP:757238147
1235 1235 g, t dbSNP:201715311
1240 1240 a, g dbSNP:761439332
1241 1241 a, g dbSNP:775998020
1244 1244 g, t dbSNP:764164301
1250 1250 c, g dbSNP:200438411
1257 1257 a, t dbSNP:775522161
1266 1266 c, g, t dbSNP:201792381
1275 1275 -, c dbSNP:770887864
1275 1275 c, g, t dbSNP:200772442
1282 1282 c, g dbSNP:771045093
1288 1288 a, t dbSNP:200154785
1290 1290 c, t dbSNP:749453173
1296 1296 a, g dbSNP:748168213
1297 1297 c, t dbSNP:781704759
1298 1298 a, g dbSNP:769143039
1311 1311 a, g dbSNP:747438691
1322 1322 c, t dbSNP:780257087
1323 1323 a, g dbSNP:141331202
1337 1337 c, g, t dbSNP:199526286
1338 1338 a, g dbSNP:755703063
1344 1344 -, c dbSNP:34725003
1344 1344 c, g dbSNP:752243493
1357 1357 a, g dbSNP:767629922
1358 1358 c, t dbSNP:759363264
1391 1391 a, g dbSNP:751421017
1395 1395 g, t dbSNP:766116984
1397 1397 a, g dbSNP:762740679
1408 1408 a, g dbSNP:773436278
1410 1410 c, g dbSNP:201668897
1413 1413 a, g dbSNP:761943676
1415 1415 a, g dbSNP:201739783
1421 1421 c, t dbSNP:370000560
1447 1447 c, t dbSNP:372702043
1448 1448 a, g dbSNP:556540232
1449 1449 c, g dbSNP:543363868
1453 1453 a, g dbSNP:200487832
1456 1456 a, g dbSNP:760743322
1460 1460 a, g dbSNP:775879328
1469 1469 a, g dbSNP:772622879
1479 1479 a, g dbSNP:746303118
1486 1486 a, g dbSNP:188433801
1491 1491 c, g dbSNP:141941701
1505 1505 c, t dbSNP:148180403
1508 1508 c, g dbSNP:199713404
1512 1512 a, g dbSNP:556451971
1525 1525 c, t dbSNP:749605439
1544 1544 c, t dbSNP:776204745
1545 1545 a, g dbSNP:539339652
1550 1550 a, g dbSNP:746537655
1562 1562 a, g dbSNP:201958273
1564 1564 a, t dbSNP:779589968
1579 1579 a, g dbSNP:757851929
1580 1580 a, g dbSNP:745834578
1591 1591 c, t dbSNP:778758780
1595 1595 c, t dbSNP:571652623
1597 1597 a, g dbSNP:753657231
1603 1603 a, g dbSNP:746164396
1604 1604 c, t dbSNP:756328684
1605 1605 c, t dbSNP:200548072
1606 1606 a, g dbSNP:199549173
1608 1608 c, t dbSNP:201227886
1609 1609 a, g dbSNP:182162117
1615 1615 c, g dbSNP:199641588
1616 1616 c, t dbSNP:201377759
1628 1628 c, t dbSNP:750523528
1634 1634 c, t dbSNP:200601478
1635 1635 g, t dbSNP:143794560
1639 1639 c, t dbSNP:773595106
1650 1650 c, t dbSNP:768238394
1654 1654 c, t dbSNP:369990738
1656 1656 a, c, t dbSNP:201085152
1657 1657 a, g dbSNP:200268317
1658 1658 a, g dbSNP:202013285
1663 1663 a, g dbSNP:200587958
1675 1675 a, g dbSNP:769638062
1682 1682 a, g dbSNP:199630906
1686 1686 a, c dbSNP:201384815
1687 1687 a, g dbSNP:200735206
1688 1688 g, t dbSNP:781627408
1691 1691 c, t dbSNP:755218930
1696 1696 a, g dbSNP:751737465
1697 1697 c, t dbSNP:199681584
1698 1698 a, g dbSNP:201547994
1700 1700 a, g dbSNP:758366057
1701 1701 a, g dbSNP:45588932
1706 1706 a, c, g dbSNP:765603155
1723 1723 c, t dbSNP:757700322
1730 1730 a, c, g dbSNP:767201930
1741 1741 a, g dbSNP:759171608
1744 1744 c, t dbSNP:773945115
1746 1746 c, t dbSNP:765907080
1747 1747 a, g, t dbSNP:773257494
1766 1766 a, g dbSNP:200663376
1769 1769 c, t dbSNP:769612624
1770 1770 a, g, t dbSNP:199521746
1780 1780 a, g dbSNP:201466202
1782 1782 c, t dbSNP:113145702
1784 1784 c, g, t dbSNP:200335109
1788 1788 a, g dbSNP:778188860
1803 1803 c, t dbSNP:756487053
1804 1804 a, g dbSNP:753052785
1812 1812 c, t dbSNP:779792929
1814 1814 c, t dbSNP:45537238
1818 1818 c, t dbSNP:200500889
1841 1841 a, g dbSNP:199860711
1846 1846 a, g dbSNP:750040087
1850 1850 c, t dbSNP:201877705
1851 1851 a, g dbSNP:761339914
1853 1853 a, g dbSNP:753839018
1865 1865 c, t dbSNP:200846684
1866 1866 a, g dbSNP:760615902
1877 1877 c, g dbSNP:576776689
1880 1880 a, t dbSNP:201031674
1883 1883 a, c dbSNP:553447317
1884 1884 a, g dbSNP:199586073
1889 1889 c, t dbSNP:137865262
1890 1890 c, g dbSNP:200521782
1891 1891 a, t dbSNP:771132182
1900 1900 a, g dbSNP:763057681
1913 1913 c, t dbSNP:773251655
1922 1922 c, t dbSNP:201794320
1925 1925 c, t dbSNP:748630651
1926 1926 a, g dbSNP:200769792
1938 1938 a, g dbSNP:533667466
1946 1946 c, t dbSNP:201221707
1948 1948 a, g dbSNP:778495527
1949 1949 a, c dbSNP:756941168
1950 1950 c, t dbSNP:748858141
1951 1951 c, g dbSNP:145371658
1965 1965 a, g dbSNP:755645885
1970 1970 c, t dbSNP:200150248
1971 1971 a, g dbSNP:201874897
1975 1975 c, t dbSNP:754790092
1976 1976 a, t dbSNP:201264568
1977 1977 c, t dbSNP:751367779
1979 1979 c, t dbSNP:766634145
1981 1981 a, t dbSNP:763182419
1987 1987 a, c dbSNP:199905452
1989 1989 g, t dbSNP:773379255
1990 1990 g, t dbSNP:765301301
1994 1994 c, t dbSNP:201817181
1995 1995 a, g dbSNP:140304729
1999 1999 c, t dbSNP:200088099
2000 2000 a, g dbSNP:138434918
2001 2001 a, g dbSNP:201724379
2009 2009 c, t dbSNP:150151009
2010 2010 a, g dbSNP:199887707
2013 2013 c, g dbSNP:374799888
2014 2014 a, g dbSNP:748980864
2015 2015 a, c, g dbSNP:755596937
2020 2020 c, t dbSNP:747684890
2024 2024 c, t dbSNP:781060683
2025 2025 a, g, t dbSNP:541374184
2027 2027 c, g dbSNP:201858248
2032 2032 c, g dbSNP:758117754
2033 2033 a, g dbSNP:200922667
2040 2040 a, g dbSNP:112263157
2043 2043 c, t dbSNP:761864553
2046 2046 a, g dbSNP:776739799
2048 2048 c, t dbSNP:764559840
2049 2049 a, g dbSNP:201479601
2054 2054 c, g, t dbSNP:200539821
2059 2059 c, t dbSNP:759926843
2060 2060 a, g dbSNP:773060369
2065 2065 a, t dbSNP:769486659
2067 2067 c, t dbSNP:199761619
2072 2072 g, t dbSNP:780774625
2081 2081 c, t dbSNP:201160106
2105 2105 c, t dbSNP:768007693
2117 2117 a, g dbSNP:141559720
2124 2124 a, c dbSNP:770773038
2126 2126 c, t dbSNP:749152147
2128 2128 c, t dbSNP:201104127
2134 2134 c, t dbSNP:200260102
2135 2135 c, g dbSNP:564935101
2138 2138 -, gga dbSNP:759980555
2139 2139 -, gag dbSNP:770382861
2139 2139 a, g dbSNP:201945946
2141 2141 c, g dbSNP:63750363
2142 2142 a, t dbSNP:200084346
2143 2143 c, t dbSNP:747052680
2144 2144 c, g, t dbSNP:147868600
2152 2152 c, t dbSNP:758809412
2153 2153 a, g dbSNP:144605371
2156 2156 ga, tc dbSNP:281865161
2156 2156 a, g, t dbSNP:371425292
2157 2157 a, t dbSNP:572842823
2163 2163 a, g dbSNP:63750847
2164 2164 c, t dbSNP:193922916
2166 2166 c, g dbSNP:752361848
2169 2169 a, t dbSNP:767144744
2173 2173 a, g dbSNP:559207950
2174 2174 a, g dbSNP:751006015
2176 2176 a, g dbSNP:63749953
2178 2178 a, g dbSNP:63750064
2185 2185 a, c, g, t dbSNP:148754993
2193 2193 a, g dbSNP:762823452
2195 2195 a, t dbSNP:773165294
2200 2200 a, g dbSNP:769722329
2207 2207 a, g dbSNP:199820754
2211 2211 a, g dbSNP:776543778
2216 2216 a, c dbSNP:201724975
2221 2221 c, g dbSNP:63750671
2223 2223 a, c, g dbSNP:63750579
2224 2224 a, g dbSNP:63751039
2225 2225 a, t dbSNP:768446605
2226 2226 a, g dbSNP:63749810
2250 2250 a, g dbSNP:760838173
2253 2253 a, g dbSNP:775713536
2259 2259 c, g dbSNP:63750921
2261 2261 c, t dbSNP:200388443
2265 2265 a, g dbSNP:745948082
2270 2270 c, t dbSNP:148888161
2271 2271 a, g, t dbSNP:201269325
2272 2272 g, t dbSNP:544705359
2274 2274 a, g dbSNP:200446085
2279 2279 a, c dbSNP:116650065
2283 2283 a, g dbSNP:63750066
2284 2284 c, t dbSNP:1800557
2285 2285 a, g dbSNP:749919142
2286 2286 a, g dbSNP:63750643
2287 2287 c, t dbSNP:63750973
2289 2289 a, g dbSNP:63750734
2290 2290 c, t dbSNP:63750868
2291 2291 a, g dbSNP:63750627
2292 2292 a, g dbSNP:63750399
2293 2293 c, t dbSNP:63750851
2294 2294 a, c, t dbSNP:145564988
2295 2295 a, c, g, t dbSNP:63750264
2296 2296 g, t dbSNP:63749964
2314 2314 c, t dbSNP:63751122
2318 2318 c, g dbSNP:63750151
2336 2336 c, g, t dbSNP:201020743
2354 2354 a, g dbSNP:573613532
2358 2358 a, g dbSNP:756759593
2363 2363 c, t dbSNP:145277462
2364 2364 a, g dbSNP:764079929
2366 2366 c, t dbSNP:201411134
2367 2367 a, g dbSNP:755929839
2368 2368 -, ctg dbSNP:759157514
2386 2386 a, g dbSNP:200396597
2397 2397 a, g dbSNP:551326329
2405 2405 a, g dbSNP:752508182
2408 2408 a, g dbSNP:767682190
2411 2411 c, t dbSNP:142218254
2417 2417 c, t dbSNP:774518756
2427 2427 a, g dbSNP:766455623
2429 2429 c, t dbSNP:762965666
2431 2431 a, g dbSNP:373482247
2432 2432 c, t dbSNP:139004544
2442 2442 g, t dbSNP:78280744
2444 2444 a, g dbSNP:770299479
2460 2460 a, c dbSNP:748508166
2461 2461 c, t dbSNP:777073624
2462 2462 c, t dbSNP:769101415
2464 2464 c, t dbSNP:745519536
2465 2465 c, t dbSNP:376555983
2466 2466 a, g, t dbSNP:201922766
2468 2468 a, c dbSNP:777613745
2470 2470 c, t dbSNP:201602257
2472 2472 c, g dbSNP:756058120
2477 2477 c, t dbSNP:201729239
2484 2484 a, g dbSNP:781075094
2491 2491 a, g dbSNP:754705572
2499 2499 c, t dbSNP:751797026
2503 2503 g, t dbSNP:200487986
2504 2504 c, t dbSNP:372670815
2505 2505 c, t dbSNP:763057188
2507 2507 c, t dbSNP:750491084
2508 2508 a, g dbSNP:765178974
2555 2555 c, g dbSNP:202204121
2557 2557 a, g dbSNP:200773744
2567 2567 g, t dbSNP:200154864
2598 2598 a, g dbSNP:531663676
2614 2614 c, t dbSNP:113174916
2630 2630 c, t dbSNP:201876780
2636 2636 -, c dbSNP:780350314
2637 2637 a, g dbSNP:200917677
2653 2653 a, c dbSNP:199977643
2657 2657 c, t dbSNP:201644219
2659 2659 c, g dbSNP:201380777
2722 2722 a, g dbSNP:200058308
2723 2723 a, t dbSNP:201729905
2730 2730 c, g dbSNP:568756389
2733 2733 a, g dbSNP:200591716
2748 2748 c, t dbSNP:199534609
2749 2749 c, t dbSNP:201853089
2772 2772 c, t dbSNP:755797592
2792 2792 c, t dbSNP:532876832
2794 2794 c, t dbSNP:551830226
2830 2830 c, t dbSNP:200736438
2831 2831 a, g dbSNP:187940037
2838 2838 g, t dbSNP:201377891
2846 2846 c, g dbSNP:200600383
2863 2863 a, t dbSNP:199765959
2866 2866 -, g dbSNP:532399598
2869 2869 c, t dbSNP:558948870
2870 2870 a, g dbSNP:150007519
2873 2873 a, g dbSNP:200262591
2893 2893 a, g dbSNP:201624429
2895 2895 c, g dbSNP:573263845
2910 2910 c, t dbSNP:200980048
2913 2913 a, g dbSNP:200492624
2919 2919 a, g dbSNP:202194773
2921 2921 a, g dbSNP:200981079
2933 2933 c, t dbSNP:182834675
2948 2948 a, g dbSNP:199862130
2973 2973 a, t dbSNP:201887246
3017 3017 c, t dbSNP:191651536
3036 3036 -, aa dbSNP:754292576
3042 3042 a, t dbSNP:201034704
3049 3049 a, c, t dbSNP:45455403
3050 3050 a, g dbSNP:748281356
3062 3062 a, g dbSNP:139278773
3077 3077 a, g dbSNP:201008117
3083 3083 a, g dbSNP:199680232
3109 3109 c, t dbSNP:11549660
3122 3122 c, t dbSNP:572356515
3136 3136 c, g, t dbSNP:201961275
3154 3154 c, t dbSNP:200665110
3161 3161 a, c dbSNP:199549432
3162 3162 a, g dbSNP:776885449
3176 3176 c, g, t dbSNP:186409009
3178 3178 c, t dbSNP:200286647
3180 3180 g, t dbSNP:199700901
3181 3181 c, g dbSNP:768025228
3183 3183 c, t dbSNP:146774213
3193 3193 c, g dbSNP:200603813
3194 3194 a, g dbSNP:202132811
3197 3197 c, t dbSNP:201621005
3206 3206 c, g dbSNP:200259364
3207 3207 g, t dbSNP:201942871
3216 3216 c, t dbSNP:537547227
3235 3235 a, c dbSNP:183019783
3237 3237 a, g dbSNP:200089634
3251 3251 a, g dbSNP:202057479
3253 3253 c, t dbSNP:200985813
3255 3255 a, g dbSNP:528792746
3256 3256 c, t dbSNP:199885985
3276 3276 c, t dbSNP:201885383
3277 3277 a, c dbSNP:200853376
3282 3282 a, c dbSNP:566047180
3283 3283 a, g dbSNP:199963586
3292 3292 a, c, g dbSNP:3200120
3296 3296 c, t dbSNP:201382660
3303 3303 c, t dbSNP:549234553
3312 3312 a, t dbSNP:200692470
3317 3317 a, t dbSNP:199762023
3322 3322 a, c dbSNP:201611727
3327 3327 c, t dbSNP:190880668
3343 3343 g, t dbSNP:543194262
3358 3358 a, c dbSNP:199500588
3363 3363 a, t dbSNP:201539056
3367 3367 a, c dbSNP:200379862
3369 3369 a, g dbSNP:533043229
3372 3372 c, g dbSNP:202081585
3373 3373 a, g dbSNP:736479
3384 3384 g, t dbSNP:200452592
3396 3396 a, g dbSNP:1059461
3417 3417 a, t dbSNP:780567142
3421 3421 a, t dbSNP:572241749
3424 3424 c, g dbSNP:202141287
3426 3426 a, g dbSNP:45541739
3450 3450 a, c dbSNP:542107566
3451 3451 -, aga dbSNP:780586892
3453 3453 -, a dbSNP:35871145
3456 3456 a, c dbSNP:573994403
3472 3472 c, t dbSNP:199902897
3474 3474 g, t dbSNP:202108412
3483 3483 a, g dbSNP:201019734
3489 3489 c, g dbSNP:200053802
3508 3508 g, t dbSNP:201471700
3517 3517 a, g dbSNP:1059478
3518 3518 a, g dbSNP:200544221
3520 3520 a, g dbSNP:199913244
3522 3522 a, g dbSNP:758913449
3535 3535 a, g dbSNP:376822208
3562 3562 g, t dbSNP:201838604
3577 3577 a, g dbSNP:112973660

Target ORF information:

RefSeq Version NM_001204301
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204301

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGG TTCTGGGTTG
ACAAATATCA AGACGGAGGA GATCTCTGAA GTGAAGATGG ATGCAGAATT CCGACATGAC
TCAGGATATG AAGTTCATCA TCAAAAATTG GTGTTCTTTG CAGAAGATGT GGGTTCAAAC
AAAGGTGCAA TCATTGGACT CATGGTGGGC GGTGTTGTCA TAGCGACAGT GATCGTCATC
ACCTTGGTGA TGCTGAAGAA GAAACAGTAC ACATCCATTC ATCATGGTGT GGTGGAGGTT
GACGCCGCTG TCACCCCAGA GGAGCGCCAC CTGTCCAAGA TGCAGCAGAA CGGCTACGAA
AATCCAACCT ACAAGTTCTT TGAGCAGATG CAGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27130
Accession Version NM_001136016.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2241bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311717.1, AK295621.1, Y00264.1 and BM876312.1. On Feb 24, 2011 this sequence version replaced gi:209915568. Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK295621.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGACCAAT TAGAGGACTT GTTGGTTCTG TTTATCAACT ATGTACCCAC TGATGGTAAT 
GCTGGCCTGC TGGCTGAACC CCAGATTGCC ATGTTCTGTG GCAGACTGAA CATGCACATG
AATGTCCAGA ATGGGAAGTG GGATTCAGAT CCATCAGGGA CCAAAACCTG CATTGATACC
AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA GTCTACCCTG AACTGCAGAT CACCAATGTG
GTAGAAGCCA ACCAACCAGT GACCATCCAG AACTGGTGCA AGCGGGGCCG CAAGCAGTGC
AAGACCCATC CCCACTTTGT GATTCCCTAC CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT
GCCCTTCTCG TTCCTGACAA GTGCAAATTC TTACACCAGG AGAGGATGGA TGTTTGCGAA
ACTCATCTTC ACTGGCACAC CGTCGCCAAA GAGACATGCA GTGAGAAGAG TACCAACTTG
CATGACTACG GCATGTTGCT GCCCTGCGGA ATTGACAAGT TCCGAGGGGT AGAGTTTGTG
TGTTGCCCAC TGGCTGAAGA AAGTGACAAT GTGGATTCTG CTGATGCGGA GGAGGATGAC
TCGGATGTCT GGTGGGGCGG AGCAGACACA GACTATGCAG ATGGGAGTGA AGACAAAGTA
GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT GAGGTGGAAG AAGAAGAAGC CGATGATGAC
GAGGACGATG AGGATGGTGA TGAGGTAGAG GAAGAGGCTG AGGAACCCTA CGAAGAAGCC
ACAGAGAGAA CCACCAGCAT TGCCACCACC ACCACCACCA CCACAGAGTC TGTGGAAGAG
GTGGTTCGAG AGGTGTGCTC TGAACAAGCC GAGACGGGGC CGTGCCGAGC AATGATCTCC
CGCTGGTACT TTGATGTGAC TGAAGGGAAG TGTGCCCCAT TCTTTTACGG CGGATGTGGC
GGCAACCGGA ACAACTTTGA CACAGAAGAG TACTGCATGG CCGTGTGTGG CAGCGCCATT
CCTACAACAG CAGCCAGTAC CCCTGATGCC GTTGACAAGT ATCTCGAGAC ACCTGGGGAT
GAGAATGAAC ATGCCCATTT CCAGAAAGCC AAAGAGAGGC TTGAGGCCAA GCACCGAGAG
AGAATGTCCC AGGTCATGAG AGAATGGGAA GAGGCAGAAC GTCAAGCAAA GAACTTGCCT
AAAGCTGATA AGAAGGCAGT TATCCAGCAT TTCCAGGAGA AAGTGGAATC TTTGGAACAG
GAAGCAGCCA ACGAGAGACA GCAGCTGGTG GAGACACACA TGGCCAGAGT GGAAGCCATG
CTCAATGACC GCCGCCGCCT GGCCCTGGAG AACTACATCA CCGCTCTGCA GGCTGTTCCT
CCTCGGCCTC GTCACGTGTT CAATATGCTA AAGAAGTATG TCCGCGCAGA ACAGAAGGAC
AGACAGCACA CCCTAAAGCA TTTCGAGCAT GTGCGCATGG TGGATCCCAA GAAAGCCGCT
CAGATCCGGT CCCAGGTTAT GACACACCTC CGTGTGATTT ATGAGCGCAT GAATCAGTCT
CTCTCCCTGC TCTACAACGT GCCTGCAGTG GCCGAGGAGA TTCAGGATGA AGTTGATGAG
CTGCTTCAGA AAGAGCAAAA CTATTCAGAT GACGTCTTGG CCAACATGAT TAGTGAACCA
AGGATCAGTT ACGGAAACGA TGCTCTCATG CCATCTTTGA CCGAAACGAA AACCACCGTG
GAGCTCCTTC CCGTGAATGG AGAGTTCAGC CTGGACGATC TCCAGCCGTG GCATTCTTTT
GGGGCTGACT CTGTGCCAGC CAACACAGAA AACGAAGTTG AGCCTGTTGA TGCCCGCCCT
GCTGCCGACC GAGGACTGAC CACTCGACCA GGTTCTGGGT TGACAAATAT CAAGACGGAG
GAGATCTCTG AAGTGAAGAT GGATGCAGAA TTCCGACATG ACTCAGGATA TGAAGTTCAT
CATCAAAAAT TGGTGTTCTT TGCAGAAGAT GTGGGTTCAA ACAAAGGTGC AATCATTGGA
CTCATGGTGG GCGGTGTTGT CATAGCGACA GTGATCGTCA TCACCTTGGT GATGCTGAAG
AAGAAACAGT ACACATCCAT TCATCATGGT GTGGTGGAGG TTGACGCCGC TGTCACCCCA
GAGGAGCGCC ACCTGTCCAA GATGCAGCAG AACGGCTACG AAAATCCAAC CTACAAGTTC
TTTGAGCAGA TGCAGAACTA G
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001129488.1
CDS197..2437
Misc Feature(1)167..169(+)
Misc Feature(2)251..745(+)
Misc Feature(3)269..574(+)
Misc Feature(4)575..745(+)
Misc Feature(5)1064..1207(+)
Misc Feature(6)1076..1096(+)
Misc Feature(7)1217..1771(+)
Misc Feature(8)2138..2263(+)
Misc Feature(9)2267..2422(+)
Exon (1)1..238
Gene:APP
Gene Synonym:
Exon (2)239..406
Gene:APP
Gene Synonym:
Exon (3)407..536
Gene:APP
Gene Synonym:
Exon (4)537..649
Gene:APP
Gene Synonym:
Exon (5)650..843
Gene:APP
Gene Synonym:
Exon (6)844..1046
Gene:APP
Gene Synonym:
Exon (7)1047..1214
Gene:APP
Gene Synonym:
Exon (8)1215..1348
Gene:APP
Gene Synonym:
Exon (9)1349..1423
Gene:APP
Gene Synonym:
Exon (10)1424..1582
Gene:APP
Gene Synonym:
Exon (11)1583..1711
Gene:APP
Gene Synonym:
Exon (12)1712..1811
Gene:APP
Gene Synonym:
Exon (13)1812..2033
Gene:APP
Gene Synonym:
Exon (14)2034..2087
Gene:APP
Gene Synonym:
Exon (15)2088..2188
Gene:APP
Gene Synonym:
Exon (16)2189..2335
Gene:APP
Gene Synonym:
Exon (17)2336..3557
Gene:APP
Gene Synonym:
Translation
Position Chain Variation Link
5 5 a, g dbSNP:577251761
36 36 c, g dbSNP:553972189
40 40 a, g dbSNP:540398667
50 50 g, t dbSNP:751137807
80 80 -, g dbSNP:543106337
98 98 c, t dbSNP:574808556
101 101 c, t dbSNP:552645762
115 115 a, c dbSNP:755709901
126 126 c, g dbSNP:9305282
135 135 g, t dbSNP:141051331
155 155 c, t dbSNP:575238981
164 164 c, t dbSNP:548862636
166 166 a, g dbSNP:779533146
173 173 -, g dbSNP:774950166
218 218 c, t dbSNP:553146391
230 230 a, t dbSNP:758076300
239 239 a, g dbSNP:140350218
244 244 a, c dbSNP:765279960
245 245 a, t dbSNP:761648158
246 246 c, g dbSNP:776525030
258 258 c, g dbSNP:763852444
270 270 c, g dbSNP:55979514
277 277 a, c dbSNP:760410401
292 292 c, t dbSNP:55850639
298 298 a, c dbSNP:540353454
300 300 a, g dbSNP:772213572
307 307 c, t dbSNP:745974049
311 311 c, t dbSNP:774281569
314 314 a, c dbSNP:771509390
322 322 c, t dbSNP:200069013
333 333 a, g dbSNP:749737592
334 334 g, t dbSNP:529782627
342 342 c, t dbSNP:56111408
352 352 a, g dbSNP:770316027
355 355 c, g dbSNP:748459651
357 357 c, t dbSNP:779869655
363 363 c, t dbSNP:11549661
364 364 c, g dbSNP:757977578
367 367 c, t dbSNP:201970902
368 368 a, g dbSNP:779329120
369 369 c, t dbSNP:200648330
377 377 a, g dbSNP:778250646
389 389 a, c dbSNP:11549662
393 393 a, g dbSNP:757264249
402 402 a, t dbSNP:753737986
407 407 a, c, g dbSNP:151188448
413 413 c, t dbSNP:770493889
421 421 g, t dbSNP:762382518
424 424 -, gatcac dbSNP:781218975
432 432 a, g dbSNP:777179682
437 437 a, g dbSNP:768921158
452 452 c, t dbSNP:747355134
479 479 c, t dbSNP:200347552
480 480 a, c, g dbSNP:199741007
483 483 a, g dbSNP:532382285
486 486 a, g dbSNP:777260127
493 493 a, g dbSNP:370274393
508 508 c, g dbSNP:748106962
511 511 a, c dbSNP:202145222
517 517 c, g dbSNP:781145038
532 532 c, t dbSNP:201537751
536 536 g, t dbSNP:754736666
540 540 c, g dbSNP:759854517
556 556 c, t dbSNP:142154215
559 559 c, t dbSNP:200826437
565 565 c, t dbSNP:148699407
566 566 a, g, t dbSNP:563647959
576 576 a, c dbSNP:761373193
582 582 a, g dbSNP:576712021
583 583 a, g dbSNP:768518732
597 597 a, t dbSNP:746947550
598 598 a, g dbSNP:779803206
600 600 c, g dbSNP:772020679
602 602 a, g dbSNP:200086074
603 603 a, t dbSNP:745588837
606 606 a, g dbSNP:779288025
607 607 c, t dbSNP:201724614
608 608 a, g dbSNP:200541360
610 610 c, t dbSNP:774664312
613 613 c, t dbSNP:199520480
614 614 a, g dbSNP:201573490
627 627 a, g dbSNP:200857049
634 634 c, t dbSNP:41276552
635 635 a, g dbSNP:756629390
637 637 c, t dbSNP:199591984
638 638 a, g dbSNP:201454946
640 640 c, t dbSNP:766601977
643 643 c, t dbSNP:200398369
652 652 a, g dbSNP:778848481
654 654 a, g dbSNP:771319862
659 659 a, g dbSNP:375376201
663 663 a, g dbSNP:200892475
666 666 a, g dbSNP:200117824
668 668 a, t dbSNP:749504313
670 670 c, t dbSNP:777809878
677 677 c, t dbSNP:201885206
685 685 c, t dbSNP:752661056
686 686 a, g dbSNP:201102339
691 691 a, g dbSNP:372642708
694 694 a, g dbSNP:751958426
703 703 c, t dbSNP:199905579
704 704 a, g dbSNP:201817335
714 714 a, t dbSNP:758637653
719 719 c, t dbSNP:753562272
720 720 a, g, t dbSNP:200898059
725 725 a, g dbSNP:202108340
726 726 c, t dbSNP:771317418
733 733 g, t dbSNP:760249418
743 743 c, t dbSNP:199744129
745 745 a, g dbSNP:775129285
748 748 c, g dbSNP:767631864
755 755 a, g dbSNP:759517529
762 762 a, g dbSNP:201460828
773 773 c, t dbSNP:145081708
783 783 c, t dbSNP:149995579
784 784 a, g dbSNP:368927918
798 798 c, t dbSNP:376138420
799 799 a, g dbSNP:201022619
805 805 c, g dbSNP:748325243
813 813 c, g dbSNP:781215285
815 815 a, g dbSNP:755525590
831 831 a, c dbSNP:747532838
834 834 a, c, g dbSNP:201250681
840 840 c, g dbSNP:200283638
843 843 a, g dbSNP:746717165
853 853 a, g, t dbSNP:200543884
855 855 c, t dbSNP:746313873
859 859 a, g dbSNP:779117377
863 863 a, g dbSNP:755841034
874 874 a, g dbSNP:752421353
885 885 c, t dbSNP:139819006
891 891 g, t dbSNP:201093867
892 892 a, g dbSNP:770301922
899 899 a, g dbSNP:751100831
902 902 a, g dbSNP:766405770
903 903 -, aag dbSNP:755788810
905 905 -, aag dbSNP:754150568
906 906 c, t dbSNP:762765836
907 907 c, t dbSNP:200270161
908 908 a, g dbSNP:750279232
916 916 -, cgaggacga dbSNP:756282934
916 916 c, t dbSNP:201941279
917 917 a, g dbSNP:147485129
922 922 c, t dbSNP:148832151
923 923 a, g dbSNP:200103591
924 924 a, g dbSNP:768813608
926 926 c, g dbSNP:760805196
933 933 a, g dbSNP:775431597
941 941 a, g dbSNP:532114068
945 945 a, g dbSNP:746341405
962 962 c, t dbSNP:201732035
965 965 c, t dbSNP:779428437
967 967 c, t dbSNP:140941257
968 968 a, g dbSNP:201094604
969 969 a, c dbSNP:781049584
974 974 a, g dbSNP:754672142
975 975 c, t dbSNP:751120313
987 987 c, t dbSNP:779407819
993 993 c, g dbSNP:757873970
1000 1000 -, gcc dbSNP:750896095
1001 1001 a, g dbSNP:200159151
1006 1006 a, c, t dbSNP:765151011
1007 1007 a, g, t dbSNP:202198008
1009 1009 -, cccc dbSNP:147067229
1009 1009 a, c, g dbSNP:777163427
1010 1010 a, c dbSNP:149353279
1012 1012 -, caccaccac dbSNP:768084853
1015 1015 -, caccac dbSNP:762288013
1018 1018 -, cac dbSNP:764406483
1020 1020 -, cac dbSNP:527890624
1024 1024 a, g dbSNP:775689062
1028 1028 c, g dbSNP:772069024
1037 1037 a, g dbSNP:200620364
1042 1042 g, t dbSNP:759620674
1051 1051 g, t dbSNP:755866188
1057 1057 c, t dbSNP:752479913
1058 1058 g, t dbSNP:767698341
1066 1066 c, t dbSNP:199890425
1067 1067 a, g dbSNP:751737009
1071 1071 c, t dbSNP:557227002
1072 1072 a, g, t dbSNP:773857944
1075 1075 a, g dbSNP:765778316
1077 1077 c, t dbSNP:202074408
1078 1078 a, c, g dbSNP:201294669
1082 1082 c, t dbSNP:771666332
1083 1083 a, g dbSNP:539326715
1088 1088 a, g dbSNP:773947319
1091 1091 a, g dbSNP:200539466
1098 1098 a, g, t dbSNP:202218688
1109 1109 a, g dbSNP:777701309
1112 1112 a, g dbSNP:769757835
1114 1114 g, t dbSNP:373259666
1121 1121 a, g dbSNP:747933636
1129 1129 c, t dbSNP:781018195
1130 1130 g, t dbSNP:754679397
1131 1131 a, c dbSNP:751861230
1144 1144 c, t dbSNP:150676543
1147 1147 c, t dbSNP:200016837
1148 1148 a, g dbSNP:750513875
1150 1150 a, t dbSNP:765734593
1156 1156 c, t dbSNP:201622977
1157 1157 a, g dbSNP:754207226
1158 1158 -, g dbSNP:141526793
1163 1163 c, t dbSNP:200978018
1164 1164 a, g dbSNP:370414043
1176 1176 a, g dbSNP:773998162
1178 1178 a, g dbSNP:770513095
1185 1185 a, c dbSNP:762508225
1189 1189 c, t dbSNP:772676633
1193 1193 a, g dbSNP:200074159
1197 1197 c, t dbSNP:373234317
1198 1198 c, t dbSNP:201462552
1199 1199 a, g dbSNP:768499633
1202 1202 g, t dbSNP:746740645
1205 1205 a, g dbSNP:200727285
1207 1207 c, t dbSNP:199824159
1210 1210 c, t dbSNP:750575150
1211 1211 a, g dbSNP:201045185
1213 1213 c, t dbSNP:757238147
1220 1220 a, g dbSNP:748168213
1221 1221 c, t dbSNP:781704759
1222 1222 a, g dbSNP:769143039
1235 1235 a, g dbSNP:747438691
1246 1246 c, t dbSNP:780257087
1247 1247 a, g dbSNP:141331202
1261 1261 c, g, t dbSNP:199526286
1262 1262 a, g dbSNP:755703063
1268 1268 -, c dbSNP:34725003
1268 1268 c, g dbSNP:752243493
1281 1281 a, g dbSNP:767629922
1282 1282 c, t dbSNP:759363264
1315 1315 a, g dbSNP:751421017
1319 1319 g, t dbSNP:766116984
1321 1321 a, g dbSNP:762740679
1332 1332 a, g dbSNP:773436278
1334 1334 c, g dbSNP:201668897
1337 1337 a, g dbSNP:761943676
1339 1339 a, g dbSNP:201739783
1345 1345 c, t dbSNP:370000560
1371 1371 c, t dbSNP:372702043
1372 1372 a, g dbSNP:556540232
1373 1373 c, g dbSNP:543363868
1377 1377 a, g dbSNP:200487832
1380 1380 a, g dbSNP:760743322
1384 1384 a, g dbSNP:775879328
1393 1393 a, g dbSNP:772622879
1403 1403 a, g dbSNP:746303118
1410 1410 a, g dbSNP:188433801
1415 1415 c, g dbSNP:141941701
1429 1429 c, t dbSNP:148180403
1432 1432 c, g dbSNP:199713404
1436 1436 a, g dbSNP:556451971
1449 1449 c, t dbSNP:749605439
1468 1468 c, t dbSNP:776204745
1469 1469 a, g dbSNP:539339652
1474 1474 a, g dbSNP:746537655
1486 1486 a, g dbSNP:201958273
1488 1488 a, t dbSNP:779589968
1503 1503 a, g dbSNP:757851929
1504 1504 a, g dbSNP:745834578
1515 1515 c, t dbSNP:778758780
1519 1519 c, t dbSNP:571652623
1521 1521 a, g dbSNP:753657231
1527 1527 a, g dbSNP:746164396
1528 1528 c, t dbSNP:756328684
1529 1529 c, t dbSNP:200548072
1530 1530 a, g dbSNP:199549173
1532 1532 c, t dbSNP:201227886
1533 1533 a, g dbSNP:182162117
1539 1539 c, g dbSNP:199641588
1540 1540 c, t dbSNP:201377759
1552 1552 c, t dbSNP:750523528
1558 1558 c, t dbSNP:200601478
1559 1559 g, t dbSNP:143794560
1563 1563 c, t dbSNP:773595106
1574 1574 c, t dbSNP:768238394
1578 1578 c, t dbSNP:369990738
1580 1580 a, c, t dbSNP:201085152
1581 1581 a, g dbSNP:200268317
1582 1582 a, g dbSNP:202013285
1587 1587 a, g dbSNP:200587958
1599 1599 a, g dbSNP:769638062
1606 1606 a, g dbSNP:199630906
1610 1610 a, c dbSNP:201384815
1611 1611 a, g dbSNP:200735206
1612 1612 g, t dbSNP:781627408
1615 1615 c, t dbSNP:755218930
1620 1620 a, g dbSNP:751737465
1621 1621 c, t dbSNP:199681584
1622 1622 a, g dbSNP:201547994
1624 1624 a, g dbSNP:758366057
1625 1625 a, g dbSNP:45588932
1630 1630 a, c, g dbSNP:765603155
1647 1647 c, t dbSNP:757700322
1654 1654 a, c, g dbSNP:767201930
1665 1665 a, g dbSNP:759171608
1668 1668 c, t dbSNP:773945115
1670 1670 c, t dbSNP:765907080
1671 1671 a, g, t dbSNP:773257494
1690 1690 a, g dbSNP:200663376
1693 1693 c, t dbSNP:769612624
1694 1694 a, g, t dbSNP:199521746
1704 1704 a, g dbSNP:201466202
1706 1706 c, t dbSNP:113145702
1708 1708 c, g, t dbSNP:200335109
1712 1712 a, g dbSNP:778188860
1727 1727 c, t dbSNP:756487053
1728 1728 a, g dbSNP:753052785
1736 1736 c, t dbSNP:779792929
1738 1738 c, t dbSNP:45537238
1742 1742 c, t dbSNP:200500889
1765 1765 a, g dbSNP:199860711
1770 1770 a, g dbSNP:750040087
1774 1774 c, t dbSNP:201877705
1775 1775 a, g dbSNP:761339914
1777 1777 a, g dbSNP:753839018
1789 1789 c, t dbSNP:200846684
1790 1790 a, g dbSNP:760615902
1801 1801 c, g dbSNP:576776689
1804 1804 a, t dbSNP:201031674
1807 1807 a, c dbSNP:553447317
1808 1808 a, g dbSNP:199586073
1813 1813 c, t dbSNP:137865262
1814 1814 c, g dbSNP:200521782
1815 1815 a, t dbSNP:771132182
1824 1824 a, g dbSNP:763057681
1837 1837 c, t dbSNP:773251655
1846 1846 c, t dbSNP:201794320
1849 1849 c, t dbSNP:748630651
1850 1850 a, g dbSNP:200769792
1862 1862 a, g dbSNP:533667466
1870 1870 c, t dbSNP:201221707
1872 1872 a, g dbSNP:778495527
1873 1873 a, c dbSNP:756941168
1874 1874 c, t dbSNP:748858141
1875 1875 c, g dbSNP:145371658
1889 1889 a, g dbSNP:755645885
1894 1894 c, t dbSNP:200150248
1895 1895 a, g dbSNP:201874897
1899 1899 c, t dbSNP:754790092
1900 1900 a, t dbSNP:201264568
1901 1901 c, t dbSNP:751367779
1903 1903 c, t dbSNP:766634145
1905 1905 a, t dbSNP:763182419
1911 1911 a, c dbSNP:199905452
1913 1913 g, t dbSNP:773379255
1914 1914 g, t dbSNP:765301301
1918 1918 c, t dbSNP:201817181
1919 1919 a, g dbSNP:140304729
1923 1923 c, t dbSNP:200088099
1924 1924 a, g dbSNP:138434918
1925 1925 a, g dbSNP:201724379
1933 1933 c, t dbSNP:150151009
1934 1934 a, g dbSNP:199887707
1937 1937 c, g dbSNP:374799888
1938 1938 a, g dbSNP:748980864
1939 1939 a, c, g dbSNP:755596937
1944 1944 c, t dbSNP:747684890
1948 1948 c, t dbSNP:781060683
1949 1949 a, g, t dbSNP:541374184
1951 1951 c, g dbSNP:201858248
1956 1956 c, g dbSNP:758117754
1957 1957 a, g dbSNP:200922667
1964 1964 a, g dbSNP:112263157
1967 1967 c, t dbSNP:761864553
1970 1970 a, g dbSNP:776739799
1972 1972 c, t dbSNP:764559840
1973 1973 a, g dbSNP:201479601
1978 1978 c, g, t dbSNP:200539821
1983 1983 c, t dbSNP:759926843
1984 1984 a, g dbSNP:773060369
1989 1989 a, t dbSNP:769486659
1991 1991 c, t dbSNP:199761619
1996 1996 g, t dbSNP:780774625
2005 2005 c, t dbSNP:201160106
2029 2029 c, t dbSNP:768007693
2040 2040 c, t dbSNP:771964280
2044 2044 c, t dbSNP:745710188
2050 2050 c, t dbSNP:778792696
2052 2052 a, g dbSNP:151010236
2062 2062 c, t dbSNP:145273675
2063 2063 a, g dbSNP:368159818
2065 2065 a, c, t dbSNP:201038323
2066 2066 c, g dbSNP:768182065
2067 2067 a, g dbSNP:765412723
2077 2077 c, t dbSNP:760100945
2080 2080 c, t dbSNP:199932473
2081 2081 a, c, g dbSNP:370979414
2095 2095 a, g dbSNP:141559720
2102 2102 a, c dbSNP:770773038
2104 2104 c, t dbSNP:749152147
2106 2106 c, t dbSNP:201104127
2112 2112 c, t dbSNP:200260102
2113 2113 c, g dbSNP:564935101
2116 2116 -, gga dbSNP:759980555
2117 2117 -, gag dbSNP:770382861
2117 2117 a, g dbSNP:201945946
2119 2119 c, g dbSNP:63750363
2120 2120 a, t dbSNP:200084346
2121 2121 c, t dbSNP:747052680
2122 2122 c, g, t dbSNP:147868600
2130 2130 c, t dbSNP:758809412
2131 2131 a, g dbSNP:144605371
2134 2134 ga, tc dbSNP:281865161
2134 2134 a, g, t dbSNP:371425292
2135 2135 a, t dbSNP:572842823
2141 2141 a, g dbSNP:63750847
2142 2142 c, t dbSNP:193922916
2144 2144 c, g dbSNP:752361848
2147 2147 a, t dbSNP:767144744
2151 2151 a, g dbSNP:559207950
2152 2152 a, g dbSNP:751006015
2154 2154 a, g dbSNP:63749953
2156 2156 a, g dbSNP:63750064
2163 2163 a, c, g, t dbSNP:148754993
2171 2171 a, g dbSNP:762823452
2173 2173 a, t dbSNP:773165294
2178 2178 a, g dbSNP:769722329
2185 2185 a, g dbSNP:199820754
2189 2189 a, g dbSNP:776543778
2194 2194 a, c dbSNP:201724975
2199 2199 c, g dbSNP:63750671
2201 2201 a, c, g dbSNP:63750579
2202 2202 a, g dbSNP:63751039
2203 2203 a, t dbSNP:768446605
2204 2204 a, g dbSNP:63749810
2228 2228 a, g dbSNP:760838173
2231 2231 a, g dbSNP:775713536
2237 2237 c, g dbSNP:63750921
2239 2239 c, t dbSNP:200388443
2243 2243 a, g dbSNP:745948082
2248 2248 c, t dbSNP:148888161
2249 2249 a, g, t dbSNP:201269325
2250 2250 g, t dbSNP:544705359
2252 2252 a, g dbSNP:200446085
2257 2257 a, c dbSNP:116650065
2261 2261 a, g dbSNP:63750066
2262 2262 c, t dbSNP:1800557
2263 2263 a, g dbSNP:749919142
2264 2264 a, g dbSNP:63750643
2265 2265 c, t dbSNP:63750973
2267 2267 a, g dbSNP:63750734
2268 2268 c, t dbSNP:63750868
2269 2269 a, g dbSNP:63750627
2270 2270 a, g dbSNP:63750399
2271 2271 c, t dbSNP:63750851
2272 2272 a, c, t dbSNP:145564988
2273 2273 a, c, g, t dbSNP:63750264
2274 2274 g, t dbSNP:63749964
2292 2292 c, t dbSNP:63751122
2296 2296 c, g dbSNP:63750151
2314 2314 c, g, t dbSNP:201020743
2332 2332 a, g dbSNP:573613532
2336 2336 a, g dbSNP:756759593
2341 2341 c, t dbSNP:145277462
2342 2342 a, g dbSNP:764079929
2344 2344 c, t dbSNP:201411134
2345 2345 a, g dbSNP:755929839
2346 2346 -, ctg dbSNP:759157514
2364 2364 a, g dbSNP:200396597
2375 2375 a, g dbSNP:551326329
2383 2383 a, g dbSNP:752508182
2386 2386 a, g dbSNP:767682190
2389 2389 c, t dbSNP:142218254
2395 2395 c, t dbSNP:774518756
2405 2405 a, g dbSNP:766455623
2407 2407 c, t dbSNP:762965666
2409 2409 a, g dbSNP:373482247
2410 2410 c, t dbSNP:139004544
2420 2420 g, t dbSNP:78280744
2422 2422 a, g dbSNP:770299479
2438 2438 a, c dbSNP:748508166
2439 2439 c, t dbSNP:777073624
2440 2440 c, t dbSNP:769101415
2442 2442 c, t dbSNP:745519536
2443 2443 c, t dbSNP:376555983
2444 2444 a, g, t dbSNP:201922766
2446 2446 a, c dbSNP:777613745
2448 2448 c, t dbSNP:201602257
2450 2450 c, g dbSNP:756058120
2455 2455 c, t dbSNP:201729239
2462 2462 a, g dbSNP:781075094
2469 2469 a, g dbSNP:754705572
2477 2477 c, t dbSNP:751797026
2481 2481 g, t dbSNP:200487986
2482 2482 c, t dbSNP:372670815
2483 2483 c, t dbSNP:763057188
2485 2485 c, t dbSNP:750491084
2486 2486 a, g dbSNP:765178974
2533 2533 c, g dbSNP:202204121
2535 2535 a, g dbSNP:200773744
2545 2545 g, t dbSNP:200154864
2576 2576 a, g dbSNP:531663676
2592 2592 c, t dbSNP:113174916
2608 2608 c, t dbSNP:201876780
2614 2614 -, c dbSNP:780350314
2615 2615 a, g dbSNP:200917677
2631 2631 a, c dbSNP:199977643
2635 2635 c, t dbSNP:201644219
2637 2637 c, g dbSNP:201380777
2700 2700 a, g dbSNP:200058308
2701 2701 a, t dbSNP:201729905
2708 2708 c, g dbSNP:568756389
2711 2711 a, g dbSNP:200591716
2726 2726 c, t dbSNP:199534609
2727 2727 c, t dbSNP:201853089
2750 2750 c, t dbSNP:755797592
2770 2770 c, t dbSNP:532876832
2772 2772 c, t dbSNP:551830226
2808 2808 c, t dbSNP:200736438
2809 2809 a, g dbSNP:187940037
2816 2816 g, t dbSNP:201377891
2824 2824 c, g dbSNP:200600383
2841 2841 a, t dbSNP:199765959
2844 2844 -, g dbSNP:532399598
2847 2847 c, t dbSNP:558948870
2848 2848 a, g dbSNP:150007519
2851 2851 a, g dbSNP:200262591
2871 2871 a, g dbSNP:201624429
2873 2873 c, g dbSNP:573263845
2888 2888 c, t dbSNP:200980048
2891 2891 a, g dbSNP:200492624
2897 2897 a, g dbSNP:202194773
2899 2899 a, g dbSNP:200981079
2911 2911 c, t dbSNP:182834675
2926 2926 a, g dbSNP:199862130
2951 2951 a, t dbSNP:201887246
2995 2995 c, t dbSNP:191651536
3014 3014 -, aa dbSNP:754292576
3020 3020 a, t dbSNP:201034704
3027 3027 a, c, t dbSNP:45455403
3028 3028 a, g dbSNP:748281356
3040 3040 a, g dbSNP:139278773
3055 3055 a, g dbSNP:201008117
3061 3061 a, g dbSNP:199680232
3087 3087 c, t dbSNP:11549660
3100 3100 c, t dbSNP:572356515
3114 3114 c, g, t dbSNP:201961275
3132 3132 c, t dbSNP:200665110
3139 3139 a, c dbSNP:199549432
3140 3140 a, g dbSNP:776885449
3154 3154 c, g, t dbSNP:186409009
3156 3156 c, t dbSNP:200286647
3158 3158 g, t dbSNP:199700901
3159 3159 c, g dbSNP:768025228
3161 3161 c, t dbSNP:146774213
3171 3171 c, g dbSNP:200603813
3172 3172 a, g dbSNP:202132811
3175 3175 c, t dbSNP:201621005
3184 3184 c, g dbSNP:200259364
3185 3185 g, t dbSNP:201942871
3194 3194 c, t dbSNP:537547227
3213 3213 a, c dbSNP:183019783
3215 3215 a, g dbSNP:200089634
3229 3229 a, g dbSNP:202057479
3231 3231 c, t dbSNP:200985813
3233 3233 a, g dbSNP:528792746
3234 3234 c, t dbSNP:199885985
3254 3254 c, t dbSNP:201885383
3255 3255 a, c dbSNP:200853376
3260 3260 a, c dbSNP:566047180
3261 3261 a, g dbSNP:199963586
3270 3270 a, c, g dbSNP:3200120
3274 3274 c, t dbSNP:201382660
3281 3281 c, t dbSNP:549234553
3290 3290 a, t dbSNP:200692470
3295 3295 a, t dbSNP:199762023
3300 3300 a, c dbSNP:201611727
3305 3305 c, t dbSNP:190880668
3321 3321 g, t dbSNP:543194262
3336 3336 a, c dbSNP:199500588
3341 3341 a, t dbSNP:201539056
3345 3345 a, c dbSNP:200379862
3347 3347 a, g dbSNP:533043229
3350 3350 c, g dbSNP:202081585
3351 3351 a, g dbSNP:736479
3362 3362 g, t dbSNP:200452592
3374 3374 a, g dbSNP:1059461
3395 3395 a, t dbSNP:780567142
3399 3399 a, t dbSNP:572241749
3402 3402 c, g dbSNP:202141287
3404 3404 a, g dbSNP:45541739
3428 3428 a, c dbSNP:542107566
3429 3429 -, aga dbSNP:780586892
3431 3431 -, a dbSNP:35871145
3434 3434 a, c dbSNP:573994403
3450 3450 c, t dbSNP:199902897
3452 3452 g, t dbSNP:202108412
3461 3461 a, g dbSNP:201019734
3467 3467 c, g dbSNP:200053802
3486 3486 g, t dbSNP:201471700
3495 3495 a, g dbSNP:1059478
3496 3496 a, g dbSNP:200544221
3498 3498 a, g dbSNP:199913244
3500 3500 a, g dbSNP:758913449
3513 3513 a, g dbSNP:376822208
3540 3540 g, t dbSNP:201838604
3555 3555 a, g dbSNP:112973660

Target ORF information:

RefSeq Version NM_001136016
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136016

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGACCAAT TAGAGGACTT GTTGGTTCTG TTTATCAACT ATGTACCCAC TGATGGTAAT 
GCTGGCCTGC TGGCTGAACC CCAGATTGCC ATGTTCTGTG GCAGACTGAA CATGCACATG
AATGTCCAGA ATGGGAAGTG GGATTCAGAT CCATCAGGGA CCAAAACCTG CATTGATACC
AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA GTCTACCCTG AACTGCAGAT CACCAATGTG
GTAGAAGCCA ACCAACCAGT GACCATCCAG AACTGGTGCA AGCGGGGCCG CAAGCAGTGC
AAGACCCATC CCCACTTTGT GATTCCCTAC CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT
GCCCTTCTCG TTCCTGACAA GTGCAAATTC TTACACCAGG AGAGGATGGA TGTTTGCGAA
ACTCATCTTC ACTGGCACAC CGTCGCCAAA GAGACATGCA GTGAGAAGAG TACCAACTTG
CATGACTACG GCATGTTGCT GCCCTGCGGA ATTGACAAGT TCCGAGGGGT AGAGTTTGTG
TGTTGCCCAC TGGCTGAAGA AAGTGACAAT GTGGATTCTG CTGATGCGGA GGAGGATGAC
TCGGATGTCT GGTGGGGCGG AGCAGACACA GACTATGCAG ATGGGAGTGA AGACAAAGTA
GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT GAGGTGGAAG AAGAAGAAGC CGATGATGAC
GAGGACGATG AGGATGGTGA TGAGGTAGAG GAAGAGGCTG AGGAACCCTA CGAAGAAGCC
ACAGAGAGAA CCACCAGCAT TGCCACCACC ACCACCACCA CCACAGAGTC TGTGGAAGAG
GTGGTTCGAG AGGTGTGCTC TGAACAAGCC GAGACGGGGC CGTGCCGAGC AATGATCTCC
CGCTGGTACT TTGATGTGAC TGAAGGGAAG TGTGCCCCAT TCTTTTACGG CGGATGTGGC
GGCAACCGGA ACAACTTTGA CACAGAAGAG TACTGCATGG CCGTGTGTGG CAGCGCCATT
CCTACAACAG CAGCCAGTAC CCCTGATGCC GTTGACAAGT ATCTCGAGAC ACCTGGGGAT
GAGAATGAAC ATGCCCATTT CCAGAAAGCC AAAGAGAGGC TTGAGGCCAA GCACCGAGAG
AGAATGTCCC AGGTCATGAG AGAATGGGAA GAGGCAGAAC GTCAAGCAAA GAACTTGCCT
AAAGCTGATA AGAAGGCAGT TATCCAGCAT TTCCAGGAGA AAGTGGAATC TTTGGAACAG
GAAGCAGCCA ACGAGAGACA GCAGCTGGTG GAGACACACA TGGCCAGAGT GGAAGCCATG
CTCAATGACC GCCGCCGCCT GGCCCTGGAG AACTACATCA CCGCTCTGCA GGCTGTTCCT
CCTCGGCCTC GTCACGTGTT CAATATGCTA AAGAAGTATG TCCGCGCAGA ACAGAAGGAC
AGACAGCACA CCCTAAAGCA TTTCGAGCAT GTGCGCATGG TGGATCCCAA GAAAGCCGCT
CAGATCCGGT CCCAGGTTAT GACACACCTC CGTGTGATTT ATGAGCGCAT GAATCAGTCT
CTCTCCCTGC TCTACAACGT GCCTGCAGTG GCCGAGGAGA TTCAGGATGA AGTTGATGAG
CTGCTTCAGA AAGAGCAAAA CTATTCAGAT GACGTCTTGG CCAACATGAT TAGTGAACCA
AGGATCAGTT ACGGAAACGA TGCTCTCATG CCATCTTTGA CCGAAACGAA AACCACCGTG
GAGCTCCTTC CCGTGAATGG AGAGTTCAGC CTGGACGATC TCCAGCCGTG GCATTCTTTT
GGGGCTGACT CTGTGCCAGC CAACACAGAA AACGAAGTTG AGCCTGTTGA TGCCCGCCCT
GCTGCCGACC GAGGACTGAC CACTCGACCA GGTTCTGGGT TGACAAATAT CAAGACGGAG
GAGATCTCTG AAGTGAAGAT GGATGCAGAA TTCCGACATG ACTCAGGATA TGAAGTTCAT
CATCAAAAAT TGGTGTTCTT TGCAGAAGAT GTGGGTTCAA ACAAAGGTGC AATCATTGGA
CTCATGGTGG GCGGTGTTGT CATAGCGACA GTGATCGTCA TCACCTTGGT GATGCTGAAG
AAGAAACAGT ACACATCCAT TCATCATGGT GTGGTGGAGG TTGACGCCGC TGTCACCCCA
GAGGAGCGCC ACCTGTCCAA GATGCAGCAG AACGGCTACG AAAATCCAAC CTACAAGTTC
TTTGAGCAGA TGCAGAACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27184
Accession Version NM_001136131.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1983bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform g
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK296229.1, Y00264.1 and BM876312.1. On Feb 24, 2011 this sequence version replaced gi:209915574. Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK296229.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTGTG GCAGACTGAA CATGCACATG AATGTCCAGA ATGGGAAGTG GGATTCAGAT 
CCATCAGGGA CCAAAACCTG CATTGATACC AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA
GTCTACCCTG AACTGCAGAT CACCAATGTG GTAGAAGCCA ACCAACCAGT GACCATCCAG
AACTGGTGCA AGCGGGGCCG CAAGCAGTGC AAGACCCATC CCCACTTTGT GATTCCCTAC
CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT GCCCTTCTCG TTCCTGACAA GTGCAAATTC
TTACACCAGG AGAGGATGGA TGTTTGCGAA ACTCATCTTC ACTGGCACAC CGTCGCCAAA
GAGACATGCA GTGAGAAGAG TACCAACTTG CATGACTACG GCATGTTGCT GCCCTGCGGA
ATTGACAAGT TCCGAGGGGT AGAGTTTGTG TGTTGCCCAC TGGCTGAAGA AAGTGACAAT
GTGGATTCTG CTGATGCGGA GGAGGATGAC TCGGATGTCT GGTGGGGCGG AGCAGACACA
GACTATGCAG ATGGGAGTGA AGACAAAGTA GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT
GAGGTGGAAG AAGAAGAAGC CGATGATGAC GAGGACGATG AGGATGGTGA TGAGGTAGAG
GAAGAGGCTG AGGAACCCTA CGAAGAAGCC ACAGAGAGAA CCACCAGCAT TGCCACCACC
ACCACCACCA CCACAGAGTC TGTGGAAGAG GTGGTTCGAG TTCCTACAAC AGCAGCCAGT
ACCCCTGATG CCGTTGACAA GTATCTCGAG ACACCTGGGG ATGAGAATGA ACATGCCCAT
TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC AAGCACCGAG AGAGAATGTC CCAGGTCATG
AGAGAATGGG AAGAGGCAGA ACGTCAAGCA AAGAACTTGC CTAAAGCTGA TAAGAAGGCA
GTTATCCAGC ATTTCCAGGA GAAAGTGGAA TCTTTGGAAC AGGAAGCAGC CAACGAGAGA
CAGCAGCTGG TGGAGACACA CATGGCCAGA GTGGAAGCCA TGCTCAATGA CCGCCGCCGC
CTGGCCCTGG AGAACTACAT CACCGCTCTG CAGGCTGTTC CTCCTCGGCC TCGTCACGTG
TTCAATATGC TAAAGAAGTA TGTCCGCGCA GAACAGAAGG ACAGACAGCA CACCCTAAAG
CATTTCGAGC ATGTGCGCAT GGTGGATCCC AAGAAAGCCG CTCAGATCCG GTCCCAGGTT
ATGACACACC TCCGTGTGAT TTATGAGCGC ATGAATCAGT CTCTCTCCCT GCTCTACAAC
GTGCCTGCAG TGGCCGAGGA GATTCAGGAT GAAGTTGATG AGCTGCTTCA GAAAGAGCAA
AACTATTCAG ATGACGTCTT GGCCAACATG ATTAGTGAAC CAAGGATCAG TTACGGAAAC
GATGCTCTCA TGCCATCTTT GACCGAAACG AAAACCACCG TGGAGCTCCT TCCCGTGAAT
GGAGAGTTCA GCCTGGACGA TCTCCAGCCG TGGCATTCTT TTGGGGCTGA CTCTGTGCCA
GCCAACACAG AAAACGAAGT TGAGCCTGTT GATGCCCGCC CTGCTGCCGA CCGAGGACTG
ACCACTCGAC CAGGTTCTGG GTTGACAAAT ATCAAGACGG AGGAGATCTC TGAAGTGAAG
ATGGATGCAG AATTCCGACA TGACTCAGGA TATGAAGTTC ATCATCAAAA ATTGGTGTTC
TTTGCAGAAG ATGTGGGTTC AAACAAAGGT GCAATCATTG GACTCATGGT GGGCGGTGTT
GTCATAGCGA CAGTGATCGT CATCACCTTG GTGATGCTGA AGAAGAAACA GTACACATCC
ATTCATCATG GTGTGGTGGA GGTTGACGCC GCTGTCACCC CAGAGGAGCG CCACCTGTCC
AAGATGCAGC AGAACGGCTA CGAAAATCCA ACCTACAAGT TCTTTGAGCA GATGCAGAAC
TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001129603.1
CDS193..2175
Misc Feature(1)67..69(+)
Misc Feature(2)193..651(+)
Misc Feature(3)193..480(+)
Misc Feature(4)481..651(+)
Misc Feature(5)955..1509(+)
Misc Feature(6)1876..2001(+)
Misc Feature(7)2005..2160(+)
Exon (1)1..144
Gene:APP
Gene Synonym:
Exon (2)145..312
Gene:APP
Gene Synonym:
Exon (3)313..442
Gene:APP
Gene Synonym:
Exon (4)443..555
Gene:APP
Gene Synonym:
Exon (5)556..749
Gene:APP
Gene Synonym:
Exon (6)750..952
Gene:APP
Gene Synonym:
Exon (7)953..1086
Gene:APP
Gene Synonym:
Exon (8)1087..1161
Gene:APP
Gene Synonym:
Exon (9)1162..1320
Gene:APP
Gene Synonym:
Exon (10)1321..1449
Gene:APP
Gene Synonym:
Exon (11)1450..1549
Gene:APP
Gene Synonym:
Exon (12)1550..1771
Gene:APP
Gene Synonym:
Exon (13)1772..1825
Gene:APP
Gene Synonym:
Exon (14)1826..1926
Gene:APP
Gene Synonym:
Exon (15)1927..2073
Gene:APP
Gene Synonym:
Exon (16)2074..3295
Gene:APP
Gene Synonym:
Translation
Position Chain Variation Link
55 55 g, t dbSNP:565848312
145 145 a, g dbSNP:140350218
150 150 a, c dbSNP:765279960
151 151 a, t dbSNP:761648158
152 152 c, g dbSNP:776525030
164 164 c, g dbSNP:763852444
176 176 c, g dbSNP:55979514
183 183 a, c dbSNP:760410401
198 198 c, t dbSNP:55850639
204 204 a, c dbSNP:540353454
206 206 a, g dbSNP:772213572
213 213 c, t dbSNP:745974049
217 217 c, t dbSNP:774281569
220 220 a, c dbSNP:771509390
228 228 c, t dbSNP:200069013
239 239 a, g dbSNP:749737592
240 240 g, t dbSNP:529782627
248 248 c, t dbSNP:56111408
258 258 a, g dbSNP:770316027
261 261 c, g dbSNP:748459651
263 263 c, t dbSNP:779869655
269 269 c, t dbSNP:11549661
270 270 c, g dbSNP:757977578
273 273 c, t dbSNP:201970902
274 274 a, g dbSNP:779329120
275 275 c, t dbSNP:200648330
283 283 a, g dbSNP:778250646
295 295 a, c dbSNP:11549662
299 299 a, g dbSNP:757264249
308 308 a, t dbSNP:753737986
313 313 a, c, g dbSNP:151188448
319 319 c, t dbSNP:770493889
327 327 g, t dbSNP:762382518
330 330 -, gatcac dbSNP:781218975
338 338 a, g dbSNP:777179682
343 343 a, g dbSNP:768921158
358 358 c, t dbSNP:747355134
385 385 c, t dbSNP:200347552
386 386 a, c, g dbSNP:199741007
389 389 a, g dbSNP:532382285
392 392 a, g dbSNP:777260127
399 399 a, g dbSNP:370274393
414 414 c, g dbSNP:748106962
417 417 a, c dbSNP:202145222
423 423 c, g dbSNP:781145038
438 438 c, t dbSNP:201537751
442 442 g, t dbSNP:754736666
446 446 c, g dbSNP:759854517
462 462 c, t dbSNP:142154215
465 465 c, t dbSNP:200826437
471 471 c, t dbSNP:148699407
472 472 a, g, t dbSNP:563647959
482 482 a, c dbSNP:761373193
488 488 a, g dbSNP:576712021
489 489 a, g dbSNP:768518732
503 503 a, t dbSNP:746947550
504 504 a, g dbSNP:779803206
506 506 c, g dbSNP:772020679
508 508 a, g dbSNP:200086074
509 509 a, t dbSNP:745588837
512 512 a, g dbSNP:779288025
513 513 c, t dbSNP:201724614
514 514 a, g dbSNP:200541360
516 516 c, t dbSNP:774664312
519 519 c, t dbSNP:199520480
520 520 a, g dbSNP:201573490
533 533 a, g dbSNP:200857049
540 540 c, t dbSNP:41276552
541 541 a, g dbSNP:756629390
543 543 c, t dbSNP:199591984
544 544 a, g dbSNP:201454946
546 546 c, t dbSNP:766601977
549 549 c, t dbSNP:200398369
558 558 a, g dbSNP:778848481
560 560 a, g dbSNP:771319862
565 565 a, g dbSNP:375376201
569 569 a, g dbSNP:200892475
572 572 a, g dbSNP:200117824
574 574 a, t dbSNP:749504313
576 576 c, t dbSNP:777809878
583 583 c, t dbSNP:201885206
591 591 c, t dbSNP:752661056
592 592 a, g dbSNP:201102339
597 597 a, g dbSNP:372642708
600 600 a, g dbSNP:751958426
609 609 c, t dbSNP:199905579
610 610 a, g dbSNP:201817335
620 620 a, t dbSNP:758637653
625 625 c, t dbSNP:753562272
626 626 a, g, t dbSNP:200898059
631 631 a, g dbSNP:202108340
632 632 c, t dbSNP:771317418
639 639 g, t dbSNP:760249418
649 649 c, t dbSNP:199744129
651 651 a, g dbSNP:775129285
654 654 c, g dbSNP:767631864
661 661 a, g dbSNP:759517529
668 668 a, g dbSNP:201460828
679 679 c, t dbSNP:145081708
689 689 c, t dbSNP:149995579
690 690 a, g dbSNP:368927918
704 704 c, t dbSNP:376138420
705 705 a, g dbSNP:201022619
711 711 c, g dbSNP:748325243
719 719 c, g dbSNP:781215285
721 721 a, g dbSNP:755525590
737 737 a, c dbSNP:747532838
740 740 a, c, g dbSNP:201250681
746 746 c, g dbSNP:200283638
749 749 a, g dbSNP:746717165
759 759 a, g, t dbSNP:200543884
761 761 c, t dbSNP:746313873
765 765 a, g dbSNP:779117377
769 769 a, g dbSNP:755841034
780 780 a, g dbSNP:752421353
791 791 c, t dbSNP:139819006
797 797 g, t dbSNP:201093867
798 798 a, g dbSNP:770301922
805 805 a, g dbSNP:751100831
808 808 a, g dbSNP:766405770
809 809 -, aag dbSNP:755788810
811 811 -, aag dbSNP:754150568
812 812 c, t dbSNP:762765836
813 813 c, t dbSNP:200270161
814 814 a, g dbSNP:750279232
822 822 -, cgaggacga dbSNP:756282934
822 822 c, t dbSNP:201941279
823 823 a, g dbSNP:147485129
828 828 c, t dbSNP:148832151
829 829 a, g dbSNP:200103591
830 830 a, g dbSNP:768813608
832 832 c, g dbSNP:760805196
839 839 a, g dbSNP:775431597
847 847 a, g dbSNP:532114068
851 851 a, g dbSNP:746341405
868 868 c, t dbSNP:201732035
871 871 c, t dbSNP:779428437
873 873 c, t dbSNP:140941257
874 874 a, g dbSNP:201094604
875 875 a, c dbSNP:781049584
880 880 a, g dbSNP:754672142
881 881 c, t dbSNP:751120313
893 893 c, t dbSNP:779407819
899 899 c, g dbSNP:757873970
906 906 -, gcc dbSNP:750896095
907 907 a, g dbSNP:200159151
912 912 a, c, t dbSNP:765151011
913 913 a, g, t dbSNP:202198008
915 915 -, cccc dbSNP:147067229
915 915 a, c, g dbSNP:777163427
916 916 a, c dbSNP:149353279
918 918 -, caccaccac dbSNP:768084853
921 921 -, caccac dbSNP:762288013
924 924 -, cac dbSNP:764406483
926 926 -, cac dbSNP:527890624
930 930 a, g dbSNP:775689062
934 934 c, g dbSNP:772069024
943 943 a, g dbSNP:200620364
948 948 g, t dbSNP:759620674
958 958 a, g dbSNP:748168213
959 959 c, t dbSNP:781704759
960 960 a, g dbSNP:769143039
973 973 a, g dbSNP:747438691
984 984 c, t dbSNP:780257087
985 985 a, g dbSNP:141331202
999 999 c, g, t dbSNP:199526286
1000 1000 a, g dbSNP:755703063
1006 1006 -, c dbSNP:34725003
1006 1006 c, g dbSNP:752243493
1019 1019 a, g dbSNP:767629922
1020 1020 c, t dbSNP:759363264
1053 1053 a, g dbSNP:751421017
1057 1057 g, t dbSNP:766116984
1059 1059 a, g dbSNP:762740679
1070 1070 a, g dbSNP:773436278
1072 1072 c, g dbSNP:201668897
1075 1075 a, g dbSNP:761943676
1077 1077 a, g dbSNP:201739783
1083 1083 c, t dbSNP:370000560
1109 1109 c, t dbSNP:372702043
1110 1110 a, g dbSNP:556540232
1111 1111 c, g dbSNP:543363868
1115 1115 a, g dbSNP:200487832
1118 1118 a, g dbSNP:760743322
1122 1122 a, g dbSNP:775879328
1131 1131 a, g dbSNP:772622879
1141 1141 a, g dbSNP:746303118
1148 1148 a, g dbSNP:188433801
1153 1153 c, g dbSNP:141941701
1167 1167 c, t dbSNP:148180403
1170 1170 c, g dbSNP:199713404
1174 1174 a, g dbSNP:556451971
1187 1187 c, t dbSNP:749605439
1206 1206 c, t dbSNP:776204745
1207 1207 a, g dbSNP:539339652
1212 1212 a, g dbSNP:746537655
1224 1224 a, g dbSNP:201958273
1226 1226 a, t dbSNP:779589968
1241 1241 a, g dbSNP:757851929
1242 1242 a, g dbSNP:745834578
1253 1253 c, t dbSNP:778758780
1257 1257 c, t dbSNP:571652623
1259 1259 a, g dbSNP:753657231
1265 1265 a, g dbSNP:746164396
1266 1266 c, t dbSNP:756328684
1267 1267 c, t dbSNP:200548072
1268 1268 a, g dbSNP:199549173
1270 1270 c, t dbSNP:201227886
1271 1271 a, g dbSNP:182162117
1277 1277 c, g dbSNP:199641588
1278 1278 c, t dbSNP:201377759
1290 1290 c, t dbSNP:750523528
1296 1296 c, t dbSNP:200601478
1297 1297 g, t dbSNP:143794560
1301 1301 c, t dbSNP:773595106
1312 1312 c, t dbSNP:768238394
1316 1316 c, t dbSNP:369990738
1318 1318 a, c, t dbSNP:201085152
1319 1319 a, g dbSNP:200268317
1320 1320 a, g dbSNP:202013285
1325 1325 a, g dbSNP:200587958
1337 1337 a, g dbSNP:769638062
1344 1344 a, g dbSNP:199630906
1348 1348 a, c dbSNP:201384815
1349 1349 a, g dbSNP:200735206
1350 1350 g, t dbSNP:781627408
1353 1353 c, t dbSNP:755218930
1358 1358 a, g dbSNP:751737465
1359 1359 c, t dbSNP:199681584
1360 1360 a, g dbSNP:201547994
1362 1362 a, g dbSNP:758366057
1363 1363 a, g dbSNP:45588932
1368 1368 a, c, g dbSNP:765603155
1385 1385 c, t dbSNP:757700322
1392 1392 a, c, g dbSNP:767201930
1403 1403 a, g dbSNP:759171608
1406 1406 c, t dbSNP:773945115
1408 1408 c, t dbSNP:765907080
1409 1409 a, g, t dbSNP:773257494
1428 1428 a, g dbSNP:200663376
1431 1431 c, t dbSNP:769612624
1432 1432 a, g, t dbSNP:199521746
1442 1442 a, g dbSNP:201466202
1444 1444 c, t dbSNP:113145702
1446 1446 c, g, t dbSNP:200335109
1450 1450 a, g dbSNP:778188860
1465 1465 c, t dbSNP:756487053
1466 1466 a, g dbSNP:753052785
1474 1474 c, t dbSNP:779792929
1476 1476 c, t dbSNP:45537238
1480 1480 c, t dbSNP:200500889
1503 1503 a, g dbSNP:199860711
1508 1508 a, g dbSNP:750040087
1512 1512 c, t dbSNP:201877705
1513 1513 a, g dbSNP:761339914
1515 1515 a, g dbSNP:753839018
1527 1527 c, t dbSNP:200846684
1528 1528 a, g dbSNP:760615902
1539 1539 c, g dbSNP:576776689
1542 1542 a, t dbSNP:201031674
1545 1545 a, c dbSNP:553447317
1546 1546 a, g dbSNP:199586073
1551 1551 c, t dbSNP:137865262
1552 1552 c, g dbSNP:200521782
1553 1553 a, t dbSNP:771132182
1562 1562 a, g dbSNP:763057681
1575 1575 c, t dbSNP:773251655
1584 1584 c, t dbSNP:201794320
1587 1587 c, t dbSNP:748630651
1588 1588 a, g dbSNP:200769792
1600 1600 a, g dbSNP:533667466
1608 1608 c, t dbSNP:201221707
1610 1610 a, g dbSNP:778495527
1611 1611 a, c dbSNP:756941168
1612 1612 c, t dbSNP:748858141
1613 1613 c, g dbSNP:145371658
1627 1627 a, g dbSNP:755645885
1632 1632 c, t dbSNP:200150248
1633 1633 a, g dbSNP:201874897
1637 1637 c, t dbSNP:754790092
1638 1638 a, t dbSNP:201264568
1639 1639 c, t dbSNP:751367779
1641 1641 c, t dbSNP:766634145
1643 1643 a, t dbSNP:763182419
1649 1649 a, c dbSNP:199905452
1651 1651 g, t dbSNP:773379255
1652 1652 g, t dbSNP:765301301
1656 1656 c, t dbSNP:201817181
1657 1657 a, g dbSNP:140304729
1661 1661 c, t dbSNP:200088099
1662 1662 a, g dbSNP:138434918
1663 1663 a, g dbSNP:201724379
1671 1671 c, t dbSNP:150151009
1672 1672 a, g dbSNP:199887707
1675 1675 c, g dbSNP:374799888
1676 1676 a, g dbSNP:748980864
1677 1677 a, c, g dbSNP:755596937
1682 1682 c, t dbSNP:747684890
1686 1686 c, t dbSNP:781060683
1687 1687 a, g, t dbSNP:541374184
1689 1689 c, g dbSNP:201858248
1694 1694 c, g dbSNP:758117754
1695 1695 a, g dbSNP:200922667
1702 1702 a, g dbSNP:112263157
1705 1705 c, t dbSNP:761864553
1708 1708 a, g dbSNP:776739799
1710 1710 c, t dbSNP:764559840
1711 1711 a, g dbSNP:201479601
1716 1716 c, g, t dbSNP:200539821
1721 1721 c, t dbSNP:759926843
1722 1722 a, g dbSNP:773060369
1727 1727 a, t dbSNP:769486659
1729 1729 c, t dbSNP:199761619
1734 1734 g, t dbSNP:780774625
1743 1743 c, t dbSNP:201160106
1767 1767 c, t dbSNP:768007693
1778 1778 c, t dbSNP:771964280
1782 1782 c, t dbSNP:745710188
1788 1788 c, t dbSNP:778792696
1790 1790 a, g dbSNP:151010236
1800 1800 c, t dbSNP:145273675
1801 1801 a, g dbSNP:368159818
1803 1803 a, c, t dbSNP:201038323
1804 1804 c, g dbSNP:768182065
1805 1805 a, g dbSNP:765412723
1815 1815 c, t dbSNP:760100945
1818 1818 c, t dbSNP:199932473
1819 1819 a, c, g dbSNP:370979414
1833 1833 a, g dbSNP:141559720
1840 1840 a, c dbSNP:770773038
1842 1842 c, t dbSNP:749152147
1844 1844 c, t dbSNP:201104127
1850 1850 c, t dbSNP:200260102
1851 1851 c, g dbSNP:564935101
1854 1854 -, gga dbSNP:759980555
1855 1855 -, gag dbSNP:770382861
1855 1855 a, g dbSNP:201945946
1857 1857 c, g dbSNP:63750363
1858 1858 a, t dbSNP:200084346
1859 1859 c, t dbSNP:747052680
1860 1860 c, g, t dbSNP:147868600
1868 1868 c, t dbSNP:758809412
1869 1869 a, g dbSNP:144605371
1872 1872 ga, tc dbSNP:281865161
1872 1872 a, g, t dbSNP:371425292
1873 1873 a, t dbSNP:572842823
1879 1879 a, g dbSNP:63750847
1880 1880 c, t dbSNP:193922916
1882 1882 c, g dbSNP:752361848
1885 1885 a, t dbSNP:767144744
1889 1889 a, g dbSNP:559207950
1890 1890 a, g dbSNP:751006015
1892 1892 a, g dbSNP:63749953
1894 1894 a, g dbSNP:63750064
1901 1901 a, c, g, t dbSNP:148754993
1909 1909 a, g dbSNP:762823452
1911 1911 a, t dbSNP:773165294
1916 1916 a, g dbSNP:769722329
1923 1923 a, g dbSNP:199820754
1927 1927 a, g dbSNP:776543778
1932 1932 a, c dbSNP:201724975
1937 1937 c, g dbSNP:63750671
1939 1939 a, c, g dbSNP:63750579
1940 1940 a, g dbSNP:63751039
1941 1941 a, t dbSNP:768446605
1942 1942 a, g dbSNP:63749810
1966 1966 a, g dbSNP:760838173
1969 1969 a, g dbSNP:775713536
1975 1975 c, g dbSNP:63750921
1977 1977 c, t dbSNP:200388443
1981 1981 a, g dbSNP:745948082
1986 1986 c, t dbSNP:148888161
1987 1987 a, g, t dbSNP:201269325
1988 1988 g, t dbSNP:544705359
1990 1990 a, g dbSNP:200446085
1995 1995 a, c dbSNP:116650065
1999 1999 a, g dbSNP:63750066
2000 2000 c, t dbSNP:1800557
2001 2001 a, g dbSNP:749919142
2002 2002 a, g dbSNP:63750643
2003 2003 c, t dbSNP:63750973
2005 2005 a, g dbSNP:63750734
2006 2006 c, t dbSNP:63750868
2007 2007 a, g dbSNP:63750627
2008 2008 a, g dbSNP:63750399
2009 2009 c, t dbSNP:63750851
2010 2010 a, c, t dbSNP:145564988
2011 2011 a, c, g, t dbSNP:63750264
2012 2012 g, t dbSNP:63749964
2030 2030 c, t dbSNP:63751122
2034 2034 c, g dbSNP:63750151
2052 2052 c, g, t dbSNP:201020743
2070 2070 a, g dbSNP:573613532
2074 2074 a, g dbSNP:756759593
2079 2079 c, t dbSNP:145277462
2080 2080 a, g dbSNP:764079929
2082 2082 c, t dbSNP:201411134
2083 2083 a, g dbSNP:755929839
2084 2084 -, ctg dbSNP:759157514
2102 2102 a, g dbSNP:200396597
2113 2113 a, g dbSNP:551326329
2121 2121 a, g dbSNP:752508182
2124 2124 a, g dbSNP:767682190
2127 2127 c, t dbSNP:142218254
2133 2133 c, t dbSNP:774518756
2143 2143 a, g dbSNP:766455623
2145 2145 c, t dbSNP:762965666
2147 2147 a, g dbSNP:373482247
2148 2148 c, t dbSNP:139004544
2158 2158 g, t dbSNP:78280744
2160 2160 a, g dbSNP:770299479
2176 2176 a, c dbSNP:748508166
2177 2177 c, t dbSNP:777073624
2178 2178 c, t dbSNP:769101415
2180 2180 c, t dbSNP:745519536
2181 2181 c, t dbSNP:376555983
2182 2182 a, g, t dbSNP:201922766
2184 2184 a, c dbSNP:777613745
2186 2186 c, t dbSNP:201602257
2188 2188 c, g dbSNP:756058120
2193 2193 c, t dbSNP:201729239
2200 2200 a, g dbSNP:781075094
2207 2207 a, g dbSNP:754705572
2215 2215 c, t dbSNP:751797026
2219 2219 g, t dbSNP:200487986
2220 2220 c, t dbSNP:372670815
2221 2221 c, t dbSNP:763057188
2223 2223 c, t dbSNP:750491084
2224 2224 a, g dbSNP:765178974
2271 2271 c, g dbSNP:202204121
2273 2273 a, g dbSNP:200773744
2283 2283 g, t dbSNP:200154864
2314 2314 a, g dbSNP:531663676
2330 2330 c, t dbSNP:113174916
2346 2346 c, t dbSNP:201876780
2352 2352 -, c dbSNP:780350314
2353 2353 a, g dbSNP:200917677
2369 2369 a, c dbSNP:199977643
2373 2373 c, t dbSNP:201644219
2375 2375 c, g dbSNP:201380777
2438 2438 a, g dbSNP:200058308
2439 2439 a, t dbSNP:201729905
2446 2446 c, g dbSNP:568756389
2449 2449 a, g dbSNP:200591716
2464 2464 c, t dbSNP:199534609
2465 2465 c, t dbSNP:201853089
2488 2488 c, t dbSNP:755797592
2508 2508 c, t dbSNP:532876832
2510 2510 c, t dbSNP:551830226
2546 2546 c, t dbSNP:200736438
2547 2547 a, g dbSNP:187940037
2554 2554 g, t dbSNP:201377891
2562 2562 c, g dbSNP:200600383
2579 2579 a, t dbSNP:199765959
2582 2582 -, g dbSNP:532399598
2585 2585 c, t dbSNP:558948870
2586 2586 a, g dbSNP:150007519
2589 2589 a, g dbSNP:200262591
2609 2609 a, g dbSNP:201624429
2611 2611 c, g dbSNP:573263845
2626 2626 c, t dbSNP:200980048
2629 2629 a, g dbSNP:200492624
2635 2635 a, g dbSNP:202194773
2637 2637 a, g dbSNP:200981079
2649 2649 c, t dbSNP:182834675
2664 2664 a, g dbSNP:199862130
2689 2689 a, t dbSNP:201887246
2733 2733 c, t dbSNP:191651536
2752 2752 -, aa dbSNP:754292576
2758 2758 a, t dbSNP:201034704
2765 2765 a, c, t dbSNP:45455403
2766 2766 a, g dbSNP:748281356
2778 2778 a, g dbSNP:139278773
2793 2793 a, g dbSNP:201008117
2799 2799 a, g dbSNP:199680232
2825 2825 c, t dbSNP:11549660
2838 2838 c, t dbSNP:572356515
2852 2852 c, g, t dbSNP:201961275
2870 2870 c, t dbSNP:200665110
2877 2877 a, c dbSNP:199549432
2878 2878 a, g dbSNP:776885449
2892 2892 c, g, t dbSNP:186409009
2894 2894 c, t dbSNP:200286647
2896 2896 g, t dbSNP:199700901
2897 2897 c, g dbSNP:768025228
2899 2899 c, t dbSNP:146774213
2909 2909 c, g dbSNP:200603813
2910 2910 a, g dbSNP:202132811
2913 2913 c, t dbSNP:201621005
2922 2922 c, g dbSNP:200259364
2923 2923 g, t dbSNP:201942871
2932 2932 c, t dbSNP:537547227
2951 2951 a, c dbSNP:183019783
2953 2953 a, g dbSNP:200089634
2967 2967 a, g dbSNP:202057479
2969 2969 c, t dbSNP:200985813
2971 2971 a, g dbSNP:528792746
2972 2972 c, t dbSNP:199885985
2992 2992 c, t dbSNP:201885383
2993 2993 a, c dbSNP:200853376
2998 2998 a, c dbSNP:566047180
2999 2999 a, g dbSNP:199963586
3008 3008 a, c, g dbSNP:3200120
3012 3012 c, t dbSNP:201382660
3019 3019 c, t dbSNP:549234553
3028 3028 a, t dbSNP:200692470
3033 3033 a, t dbSNP:199762023
3038 3038 a, c dbSNP:201611727
3043 3043 c, t dbSNP:190880668
3059 3059 g, t dbSNP:543194262
3074 3074 a, c dbSNP:199500588
3079 3079 a, t dbSNP:201539056
3083 3083 a, c dbSNP:200379862
3085 3085 a, g dbSNP:533043229
3088 3088 c, g dbSNP:202081585
3089 3089 a, g dbSNP:736479
3100 3100 g, t dbSNP:200452592
3112 3112 a, g dbSNP:1059461
3133 3133 a, t dbSNP:780567142
3137 3137 a, t dbSNP:572241749
3140 3140 c, g dbSNP:202141287
3142 3142 a, g dbSNP:45541739
3166 3166 a, c dbSNP:542107566
3167 3167 -, aga dbSNP:780586892
3169 3169 -, a dbSNP:35871145
3172 3172 a, c dbSNP:573994403
3188 3188 c, t dbSNP:199902897
3190 3190 g, t dbSNP:202108412
3199 3199 a, g dbSNP:201019734
3205 3205 c, g dbSNP:200053802
3224 3224 g, t dbSNP:201471700
3233 3233 a, g dbSNP:1059478
3234 3234 a, g dbSNP:200544221
3236 3236 a, g dbSNP:199913244
3238 3238 a, g dbSNP:758913449
3251 3251 a, g dbSNP:376822208
3278 3278 g, t dbSNP:201838604
3293 3293 a, g dbSNP:112973660

Target ORF information:

RefSeq Version NM_001136131
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136131

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTGTG GCAGACTGAA CATGCACATG AATGTCCAGA ATGGGAAGTG GGATTCAGAT 
CCATCAGGGA CCAAAACCTG CATTGATACC AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA
GTCTACCCTG AACTGCAGAT CACCAATGTG GTAGAAGCCA ACCAACCAGT GACCATCCAG
AACTGGTGCA AGCGGGGCCG CAAGCAGTGC AAGACCCATC CCCACTTTGT GATTCCCTAC
CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT GCCCTTCTCG TTCCTGACAA GTGCAAATTC
TTACACCAGG AGAGGATGGA TGTTTGCGAA ACTCATCTTC ACTGGCACAC CGTCGCCAAA
GAGACATGCA GTGAGAAGAG TACCAACTTG CATGACTACG GCATGTTGCT GCCCTGCGGA
ATTGACAAGT TCCGAGGGGT AGAGTTTGTG TGTTGCCCAC TGGCTGAAGA AAGTGACAAT
GTGGATTCTG CTGATGCGGA GGAGGATGAC TCGGATGTCT GGTGGGGCGG AGCAGACACA
GACTATGCAG ATGGGAGTGA AGACAAAGTA GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT
GAGGTGGAAG AAGAAGAAGC CGATGATGAC GAGGACGATG AGGATGGTGA TGAGGTAGAG
GAAGAGGCTG AGGAACCCTA CGAAGAAGCC ACAGAGAGAA CCACCAGCAT TGCCACCACC
ACCACCACCA CCACAGAGTC TGTGGAAGAG GTGGTTCGAG TTCCTACAAC AGCAGCCAGT
ACCCCTGATG CCGTTGACAA GTATCTCGAG ACACCTGGGG ATGAGAATGA ACATGCCCAT
TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC AAGCACCGAG AGAGAATGTC CCAGGTCATG
AGAGAATGGG AAGAGGCAGA ACGTCAAGCA AAGAACTTGC CTAAAGCTGA TAAGAAGGCA
GTTATCCAGC ATTTCCAGGA GAAAGTGGAA TCTTTGGAAC AGGAAGCAGC CAACGAGAGA
CAGCAGCTGG TGGAGACACA CATGGCCAGA GTGGAAGCCA TGCTCAATGA CCGCCGCCGC
CTGGCCCTGG AGAACTACAT CACCGCTCTG CAGGCTGTTC CTCCTCGGCC TCGTCACGTG
TTCAATATGC TAAAGAAGTA TGTCCGCGCA GAACAGAAGG ACAGACAGCA CACCCTAAAG
CATTTCGAGC ATGTGCGCAT GGTGGATCCC AAGAAAGCCG CTCAGATCCG GTCCCAGGTT
ATGACACACC TCCGTGTGAT TTATGAGCGC ATGAATCAGT CTCTCTCCCT GCTCTACAAC
GTGCCTGCAG TGGCCGAGGA GATTCAGGAT GAAGTTGATG AGCTGCTTCA GAAAGAGCAA
AACTATTCAG ATGACGTCTT GGCCAACATG ATTAGTGAAC CAAGGATCAG TTACGGAAAC
GATGCTCTCA TGCCATCTTT GACCGAAACG AAAACCACCG TGGAGCTCCT TCCCGTGAAT
GGAGAGTTCA GCCTGGACGA TCTCCAGCCG TGGCATTCTT TTGGGGCTGA CTCTGTGCCA
GCCAACACAG AAAACGAAGT TGAGCCTGTT GATGCCCGCC CTGCTGCCGA CCGAGGACTG
ACCACTCGAC CAGGTTCTGG GTTGACAAAT ATCAAGACGG AGGAGATCTC TGAAGTGAAG
ATGGATGCAG AATTCCGACA TGACTCAGGA TATGAAGTTC ATCATCAAAA ATTGGTGTTC
TTTGCAGAAG ATGTGGGTTC AAACAAAGGT GCAATCATTG GACTCATGGT GGGCGGTGTT
GTCATAGCGA CAGTGATCGT CATCACCTTG GTGATGCTGA AGAAGAAACA GTACACATCC
ATTCATCATG GTGTGGTGGA GGTTGACGCC GCTGTCACCC CAGAGGAGCG CCACCTGTCC
AAGATGCAGC AGAACGGCTA CGAAAATCCA ACCTACAAGT TCTTTGAGCA GATGCAGAAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27406
Accession Version NM_001136130.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2145bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform f precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AK294534.1, BC065523.1, BC065529.1 and BM876312.1. On Apr 29, 2009 this sequence version replaced gi:209915572. Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK294534.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTC 
TACCCTGAAC TGCAGATCAC CAATGTGGTA GAAGCCAACC AACCAGTGAC CATCCAGAAC
TGGTGCAAGC GGGGCCGCAA GCAGTGCAAG ACCCATCCCC ACTTTGTGAT TCCCTACCGC
TGCTTAGTTG GTGAGTTTGT AAGTGATGCC CTTCTCGTTC CTGACAAGTG CAAATTCTTA
CACCAGGAGA GGATGGATGT TTGCGAAACT CATCTTCACT GGCACACCGT CGCCAAAGAG
ACATGCAGTG AGAAGAGTAC CAACTTGCAT GACTACGGCA TGTTGCTGCC CTGCGGAATT
GACAAGTTCC GAGGGGTAGA GTTTGTGTGT TGCCCACTGG CTGAAGAAAG TGACAATGTG
GATTCTGCTG ATGCGGAGGA GGATGACTCG GATGTCTGGT GGGGCGGAGC AGACACAGAC
TATGCAGATG GGAGTGAAGA CAAAGTAGTA GAAGTAGCAG AGGAGGAAGA AGTGGCTGAG
GTGGAAGAAG AAGAAGCCGA TGATGACGAG GACGATGAGG ATGGTGATGA GGTAGAGGAA
GAGGCTGAGG AACCCTACGA AGAAGCCACA GAGAGAACCA CCAGCATTGC CACCACCACC
ACCACCACCA CAGAGTCTGT GGAAGAGGTG GTTCGAGAGG TGTGCTCTGA ACAAGCCGAG
ACGGGGCCGT GCCGAGCAAT GATCTCCCGC TGGTACTTTG ATGTGACTGA AGGGAAGTGT
GCCCCATTCT TTTACGGCGG ATGTGGCGGC AACCGGAACA ACTTTGACAC AGAAGAGTAC
TGCATGGCCG TGTGTGGCAG CGCCATGTCC CAAAGTTTAC TCAAGACTAC CCAGGAACCT
CTTGCCCGAG ATCCTGTTAA ACTTCCTACA ACAGCAGCCA GTACCCCTGA TGCCGTTGAC
AAGTATCTCG AGACACCTGG GGATGAGAAT GAACATGCCC ATTTCCAGAA AGCCAAAGAG
AGGCTTGAGG CCAAGCACCG AGAGAGAATG TCCCAGGTCA TGAGAGAATG GGAAGAGGCA
GAACGTCAAG CAAAGAACTT GCCTAAAGCT GATAAGAAGG CAGTTATCCA GCATTTCCAG
GAGAAAGTGG AATCTTTGGA ACAGGAAGCA GCCAACGAGA GACAGCAGCT GGTGGAGACA
CACATGGCCA GAGTGGAAGC CATGCTCAAT GACCGCCGCC GCCTGGCCCT GGAGAACTAC
ATCACCGCTC TGCAGGCTGT TCCTCCTCGG CCTCGTCACG TGTTCAATAT GCTAAAGAAG
TATGTCCGCG CAGAACAGAA GGACAGACAG CACACCCTAA AGCATTTCGA GCATGTGCGC
ATGGTGGATC CCAAGAAAGC CGCTCAGATC CGGTCCCAGG TTATGACACA CCTCCGTGTG
ATTTATGAGC GCATGAATCA GTCTCTCTCC CTGCTCTACA ACGTGCCTGC AGTGGCCGAG
GAGATTCAGG ATGAAGTTGA TGAGCTGCTT CAGAAAGAGC AAAACTATTC AGATGACGTC
TTGGCCAACA TGATTAGTGA ACCAAGGATC AGTTACGGAA ACGATGCTCT CATGCCATCT
TTGACCGAAA CGAAAACCAC CGTGGAGCTC CTTCCCGTGA ATGGAGAGTT CAGCCTGGAC
GATCTCCAGC CGTGGCATTC TTTTGGGGCT GACTCTGTGC CAGCCAACAC AGAAAACGAA
GTTGAGCCTG TTGATGCCCG CCCTGCTGCC GACCGAGGAC TGACCACTCG ACCAGGTTCT
GGGTTGACAA ATATCAAGAC GGAGGAGATC TCTGAAGTGA AGATGGATGC AGAATTCCGA
CATGACTCAG GATATGAAGT TCATCATCAA AAATTGGTGT TCTTTGCAGA AGATGTGGGT
TCAAACAAAG GTGCAATCAT TGGACTCATG GTGGGCGGTG TTGTCATAGC GACAGTGATC
GTCATCACCT TGGTGATGCT GAAGAAGAAA CAGTACACAT CCATTCATCA TGGTGTGGTG
GAGGTTGACG CCGCTGTCAC CCCAGAGGAG CGCCACCTGT CCAAGATGCA GCAGAACGGC
TACGAAAATC CAACCTACAA GTTCTTTGAG CAGATGCAGA ACTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001129602.1
CDS201..2345
Misc Feature(1)24..26(+)
Misc Feature(2)255..425(+)
Misc Feature(3)426..596(+)
Misc Feature(4)915..1058(+)
Misc Feature(5)927..947(+)
Misc Feature(6)1125..1679(+)
Misc Feature(7)2046..2171(+)
Misc Feature(8)2175..2330(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..387
Gene:APP
Gene Synonym:
Exon (3)388..500
Gene:APP
Gene Synonym:
Exon (4)501..694
Gene:APP
Gene Synonym:
Exon (5)695..897
Gene:APP
Gene Synonym:
Exon (6)898..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1122
Gene:APP
Gene Synonym:
Exon (8)1123..1256
Gene:APP
Gene Synonym:
Exon (9)1257..1331
Gene:APP
Gene Synonym:
Exon (10)1332..1490
Gene:APP
Gene Synonym:
Exon (11)1491..1619
Gene:APP
Gene Synonym:
Exon (12)1620..1719
Gene:APP
Gene Synonym:
Exon (13)1720..1941
Gene:APP
Gene Synonym:
Exon (14)1942..1995
Gene:APP
Gene Synonym:
Exon (15)1996..2096
Gene:APP
Gene Synonym:
Exon (16)2097..2243
Gene:APP
Gene Synonym:
Exon (17)2244..3465
Gene:APP
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:200621906
2 2 a, g dbSNP:761755102
20 20 a, g dbSNP:558863815
30 30 a, c dbSNP:199610454
31 31 c, t dbSNP:538664273
34 34 c, t dbSNP:751341076
41 41 c, t dbSNP:145958140
45 45 c, g dbSNP:45476095
53 53 c, t dbSNP:536423638
66 66 a, c dbSNP:567551375
78 78 c, g dbSNP:200990709
90 90 c, g dbSNP:459543
107 107 c, t dbSNP:201528959
130 130 c, t dbSNP:531158286
152 152 c, t dbSNP:779238120
157 157 c, t dbSNP:200289921
177 177 c, g dbSNP:199527632
186 186 c, g dbSNP:754084577
187 187 c, g dbSNP:201509588
190 190 g, t dbSNP:200339053
219 219 c, g dbSNP:767211549
233 233 c, t dbSNP:754674097
242 242 c, g dbSNP:751156099
246 246 c, t dbSNP:202070273
249 249 a, g dbSNP:762505107
258 258 a, c, g dbSNP:151188448
264 264 c, t dbSNP:770493889
272 272 g, t dbSNP:762382518
275 275 -, gatcac dbSNP:781218975
283 283 a, g dbSNP:777179682
288 288 a, g dbSNP:768921158
303 303 c, t dbSNP:747355134
330 330 c, t dbSNP:200347552
331 331 a, c, g dbSNP:199741007
334 334 a, g dbSNP:532382285
337 337 a, g dbSNP:777260127
344 344 a, g dbSNP:370274393
359 359 c, g dbSNP:748106962
362 362 a, c dbSNP:202145222
368 368 c, g dbSNP:781145038
383 383 c, t dbSNP:201537751
387 387 g, t dbSNP:754736666
391 391 c, g dbSNP:759854517
407 407 c, t dbSNP:142154215
410 410 c, t dbSNP:200826437
416 416 c, t dbSNP:148699407
417 417 a, g, t dbSNP:563647959
427 427 a, c dbSNP:761373193
433 433 a, g dbSNP:576712021
434 434 a, g dbSNP:768518732
448 448 a, t dbSNP:746947550
449 449 a, g dbSNP:779803206
451 451