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APP cDNA ORF clone, Homo sapiens (human)

Gene Symbol APP
Entrez Gene ID 351
Full Name amyloid beta (A4) precursor protein
Synonyms AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
General protein information
Preferred Names
amyloid beta A4 protein
Names
amyloid beta A4 protein
preA4
protease nexin-II
peptidase nexin-II
beta-amyloid peptide
alzheimer disease amyloid protein
cerebral vascular amyloid peptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q21.3

Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]. lac of sum
Disorder MIM:

104760

Disorder Html: Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic

mRNA and Protein(s)

mRNA Protein Name
NM_001204301 NP_001191230 amyloid beta A4 protein isoform h precursor
NM_001136016 NP_001129488 amyloid beta A4 protein isoform d
NM_001136131 NP_001129603 amyloid beta A4 protein isoform g
NM_001136130 NP_001129602 amyloid beta A4 protein isoform f precursor
NM_001136129 NP_001129601 amyloid beta A4 protein isoform e precursor
NM_000484 NP_000475 amyloid beta A4 protein isoform a precursor
NM_201413 NP_958816 amyloid beta A4 protein isoform b precursor
NM_201414 NP_958817 amyloid beta A4 protein isoform c precursor
NM_001204302 NP_001191231 amyloid beta A4 protein isoform i precursor
NM_001204303 NP_001191232 amyloid beta A4 protein isoform j precursor



Homo sapiens (human) APP NP_000475.1
Pan troglodytes (chimpanzee) APP NP_001013036.1
Macaca mulatta (Rhesus monkey) APP XP_002803216.1
Canis lupus familiaris (dog) APP NP_001006601.1
Bos taurus (cattle) APP NP_001070264.1
Mus musculus (house mouse) App NP_001185752.1
Rattus norvegicus (Norway rat) App NP_062161.1
Gallus gallus (chicken) APP NP_989639.1
Danio rerio (zebrafish) appb NP_690842.1
Caenorhabditis elegans apl-1 NP_508870.3
Xenopus (Silurana) tropicalis (western clawed frog) app NP_001005698.1


Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27229 NM_001204301 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00
OHu27130 NM_001136016 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $629.30
$899.00
OHu27184
NM_001136131 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$314.50-$440.30
$629.00
OHu27406 NM_001136130 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $503.30
$719.00
OHu27126 NM_001136129 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu27259
NM_000484 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
OHu26762
NM_201413 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu26689
NM_201414 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$349.50-$489.30
$699.00
OHu27201 NM_001204302 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00
OHu27287 NM_001204303 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27229
Clone ID Related Accession (Same CDS sequence) NM_001204301
Accession Version NM_001204301.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2259bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform h precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AK294534.1, AK312326.1, Y00264.1 and BM876312.1. Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (h, also known as L-APP752) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: PMID: 1429732 Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGG TTCTGGGTTG
ACAAATATCA AGACGGAGGA GATCTCTGAA GTGAAGATGG ATGCAGAATT CCGACATGAC
TCAGGATATG AAGTTCATCA TCAAAAATTG GTGTTCTTTG CAGAAGATGT GGGTTCAAAC
AAAGGTGCAA TCATTGGACT CATGGTGGGC GGTGTTGTCA TAGCGACAGT GATCGTCATC
ACCTTGGTGA TGCTGAAGAA GAAACAGTAC ACATCCATTC ATCATGGTGT GGTGGAGGTT
GACGCCGCTG TCACCCCAGA GGAGCGCCAC CTGTCCAAGA TGCAGCAGAA CGGCTACGAA
AATCCAACCT ACAAGTTCTT TGAGCAGATG CAGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191230.1
CDS201..2459
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)594..764(+)
Misc Feature(5)1083..1226(+)
Misc Feature(6)1095..1115(+)
Misc Feature(7)1293..1847(+)
Misc Feature(8)2160..2285(+)
Misc Feature(9)2289..2444(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1233
Gene:APP
Gene Synonym:
Exon (8)1234..1290
Gene:APP
Gene Synonym:
Exon (9)1291..1424
Gene:APP
Gene Synonym:
Exon (10)1425..1499
Gene:APP
Gene Synonym:
Exon (11)1500..1658
Gene:APP
Gene Synonym:
Exon (12)1659..1787
Gene:APP
Gene Synonym:
Exon (13)1788..1887
Gene:APP
Gene Synonym:
Exon (14)1888..2109
Gene:APP
Gene Synonym:
Exon (15)2110..2210
Gene:APP
Gene Synonym:
Exon (16)2211..2357
Gene:APP
Gene Synonym:
Exon (17)2358..3579
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001204301
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204301

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGG TTCTGGGTTG
ACAAATATCA AGACGGAGGA GATCTCTGAA GTGAAGATGG ATGCAGAATT CCGACATGAC
TCAGGATATG AAGTTCATCA TCAAAAATTG GTGTTCTTTG CAGAAGATGT GGGTTCAAAC
AAAGGTGCAA TCATTGGACT CATGGTGGGC GGTGTTGTCA TAGCGACAGT GATCGTCATC
ACCTTGGTGA TGCTGAAGAA GAAACAGTAC ACATCCATTC ATCATGGTGT GGTGGAGGTT
GACGCCGCTG TCACCCCAGA GGAGCGCCAC CTGTCCAAGA TGCAGCAGAA CGGCTACGAA
AATCCAACCT ACAAGTTCTT TGAGCAGATG CAGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27130
Clone ID Related Accession (Same CDS sequence) NM_001136016
Accession Version NM_001136016.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2241bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311717.1, AK295621.1, Y00264.1 and BM876312.1. On Feb 24, 2011 this sequence version replaced gi:209915568. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK295621.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGACCAAT TAGAGGACTT GTTGGTTCTG TTTATCAACT ATGTACCCAC TGATGGTAAT 
GCTGGCCTGC TGGCTGAACC CCAGATTGCC ATGTTCTGTG GCAGACTGAA CATGCACATG
AATGTCCAGA ATGGGAAGTG GGATTCAGAT CCATCAGGGA CCAAAACCTG CATTGATACC
AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA GTCTACCCTG AACTGCAGAT CACCAATGTG
GTAGAAGCCA ACCAACCAGT GACCATCCAG AACTGGTGCA AGCGGGGCCG CAAGCAGTGC
AAGACCCATC CCCACTTTGT GATTCCCTAC CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT
GCCCTTCTCG TTCCTGACAA GTGCAAATTC TTACACCAGG AGAGGATGGA TGTTTGCGAA
ACTCATCTTC ACTGGCACAC CGTCGCCAAA GAGACATGCA GTGAGAAGAG TACCAACTTG
CATGACTACG GCATGTTGCT GCCCTGCGGA ATTGACAAGT TCCGAGGGGT AGAGTTTGTG
TGTTGCCCAC TGGCTGAAGA AAGTGACAAT GTGGATTCTG CTGATGCGGA GGAGGATGAC
TCGGATGTCT GGTGGGGCGG AGCAGACACA GACTATGCAG ATGGGAGTGA AGACAAAGTA
GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT GAGGTGGAAG AAGAAGAAGC CGATGATGAC
GAGGACGATG AGGATGGTGA TGAGGTAGAG GAAGAGGCTG AGGAACCCTA CGAAGAAGCC
ACAGAGAGAA CCACCAGCAT TGCCACCACC ACCACCACCA CCACAGAGTC TGTGGAAGAG
GTGGTTCGAG AGGTGTGCTC TGAACAAGCC GAGACGGGGC CGTGCCGAGC AATGATCTCC
CGCTGGTACT TTGATGTGAC TGAAGGGAAG TGTGCCCCAT TCTTTTACGG CGGATGTGGC
GGCAACCGGA ACAACTTTGA CACAGAAGAG TACTGCATGG CCGTGTGTGG CAGCGCCATT
CCTACAACAG CAGCCAGTAC CCCTGATGCC GTTGACAAGT ATCTCGAGAC ACCTGGGGAT
GAGAATGAAC ATGCCCATTT CCAGAAAGCC AAAGAGAGGC TTGAGGCCAA GCACCGAGAG
AGAATGTCCC AGGTCATGAG AGAATGGGAA GAGGCAGAAC GTCAAGCAAA GAACTTGCCT
AAAGCTGATA AGAAGGCAGT TATCCAGCAT TTCCAGGAGA AAGTGGAATC TTTGGAACAG
GAAGCAGCCA ACGAGAGACA GCAGCTGGTG GAGACACACA TGGCCAGAGT GGAAGCCATG
CTCAATGACC GCCGCCGCCT GGCCCTGGAG AACTACATCA CCGCTCTGCA GGCTGTTCCT
CCTCGGCCTC GTCACGTGTT CAATATGCTA AAGAAGTATG TCCGCGCAGA ACAGAAGGAC
AGACAGCACA CCCTAAAGCA TTTCGAGCAT GTGCGCATGG TGGATCCCAA GAAAGCCGCT
CAGATCCGGT CCCAGGTTAT GACACACCTC CGTGTGATTT ATGAGCGCAT GAATCAGTCT
CTCTCCCTGC TCTACAACGT GCCTGCAGTG GCCGAGGAGA TTCAGGATGA AGTTGATGAG
CTGCTTCAGA AAGAGCAAAA CTATTCAGAT GACGTCTTGG CCAACATGAT TAGTGAACCA
AGGATCAGTT ACGGAAACGA TGCTCTCATG CCATCTTTGA CCGAAACGAA AACCACCGTG
GAGCTCCTTC CCGTGAATGG AGAGTTCAGC CTGGACGATC TCCAGCCGTG GCATTCTTTT
GGGGCTGACT CTGTGCCAGC CAACACAGAA AACGAAGTTG AGCCTGTTGA TGCCCGCCCT
GCTGCCGACC GAGGACTGAC CACTCGACCA GGTTCTGGGT TGACAAATAT CAAGACGGAG
GAGATCTCTG AAGTGAAGAT GGATGCAGAA TTCCGACATG ACTCAGGATA TGAAGTTCAT
CATCAAAAAT TGGTGTTCTT TGCAGAAGAT GTGGGTTCAA ACAAAGGTGC AATCATTGGA
CTCATGGTGG GCGGTGTTGT CATAGCGACA GTGATCGTCA TCACCTTGGT GATGCTGAAG
AAGAAACAGT ACACATCCAT TCATCATGGT GTGGTGGAGG TTGACGCCGC TGTCACCCCA
GAGGAGCGCC ACCTGTCCAA GATGCAGCAG AACGGCTACG AAAATCCAAC CTACAAGTTC
TTTGAGCAGA TGCAGAACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001129488.1
CDS197..2437
Misc Feature(1)167..169(+)
Misc Feature(2)251..745(+)
Misc Feature(3)269..574(+)
Misc Feature(4)575..745(+)
Misc Feature(5)1064..1207(+)
Misc Feature(6)1076..1096(+)
Misc Feature(7)1217..1771(+)
Misc Feature(8)2138..2263(+)
Misc Feature(9)2267..2422(+)
Exon (1)1..238
Gene:APP
Gene Synonym:
Exon (2)239..406
Gene:APP
Gene Synonym:
Exon (3)407..536
Gene:APP
Gene Synonym:
Exon (4)537..649
Gene:APP
Gene Synonym:
Exon (5)650..843
Gene:APP
Gene Synonym:
Exon (6)844..1046
Gene:APP
Gene Synonym:
Exon (7)1047..1214
Gene:APP
Gene Synonym:
Exon (8)1215..1348
Gene:APP
Gene Synonym:
Exon (9)1349..1423
Gene:APP
Gene Synonym:
Exon (10)1424..1582
Gene:APP
Gene Synonym:
Exon (11)1583..1711
Gene:APP
Gene Synonym:
Exon (12)1712..1811
Gene:APP
Gene Synonym:
Exon (13)1812..2033
Gene:APP
Gene Synonym:
Exon (14)2034..2087
Gene:APP
Gene Synonym:
Exon (15)2088..2188
Gene:APP
Gene Synonym:
Exon (16)2189..2335
Gene:APP
Gene Synonym:
Exon (17)2336..3557
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001136016
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136016

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGACCAAT TAGAGGACTT GTTGGTTCTG TTTATCAACT ATGTACCCAC TGATGGTAAT 
GCTGGCCTGC TGGCTGAACC CCAGATTGCC ATGTTCTGTG GCAGACTGAA CATGCACATG
AATGTCCAGA ATGGGAAGTG GGATTCAGAT CCATCAGGGA CCAAAACCTG CATTGATACC
AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA GTCTACCCTG AACTGCAGAT CACCAATGTG
GTAGAAGCCA ACCAACCAGT GACCATCCAG AACTGGTGCA AGCGGGGCCG CAAGCAGTGC
AAGACCCATC CCCACTTTGT GATTCCCTAC CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT
GCCCTTCTCG TTCCTGACAA GTGCAAATTC TTACACCAGG AGAGGATGGA TGTTTGCGAA
ACTCATCTTC ACTGGCACAC CGTCGCCAAA GAGACATGCA GTGAGAAGAG TACCAACTTG
CATGACTACG GCATGTTGCT GCCCTGCGGA ATTGACAAGT TCCGAGGGGT AGAGTTTGTG
TGTTGCCCAC TGGCTGAAGA AAGTGACAAT GTGGATTCTG CTGATGCGGA GGAGGATGAC
TCGGATGTCT GGTGGGGCGG AGCAGACACA GACTATGCAG ATGGGAGTGA AGACAAAGTA
GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT GAGGTGGAAG AAGAAGAAGC CGATGATGAC
GAGGACGATG AGGATGGTGA TGAGGTAGAG GAAGAGGCTG AGGAACCCTA CGAAGAAGCC
ACAGAGAGAA CCACCAGCAT TGCCACCACC ACCACCACCA CCACAGAGTC TGTGGAAGAG
GTGGTTCGAG AGGTGTGCTC TGAACAAGCC GAGACGGGGC CGTGCCGAGC AATGATCTCC
CGCTGGTACT TTGATGTGAC TGAAGGGAAG TGTGCCCCAT TCTTTTACGG CGGATGTGGC
GGCAACCGGA ACAACTTTGA CACAGAAGAG TACTGCATGG CCGTGTGTGG CAGCGCCATT
CCTACAACAG CAGCCAGTAC CCCTGATGCC GTTGACAAGT ATCTCGAGAC ACCTGGGGAT
GAGAATGAAC ATGCCCATTT CCAGAAAGCC AAAGAGAGGC TTGAGGCCAA GCACCGAGAG
AGAATGTCCC AGGTCATGAG AGAATGGGAA GAGGCAGAAC GTCAAGCAAA GAACTTGCCT
AAAGCTGATA AGAAGGCAGT TATCCAGCAT TTCCAGGAGA AAGTGGAATC TTTGGAACAG
GAAGCAGCCA ACGAGAGACA GCAGCTGGTG GAGACACACA TGGCCAGAGT GGAAGCCATG
CTCAATGACC GCCGCCGCCT GGCCCTGGAG AACTACATCA CCGCTCTGCA GGCTGTTCCT
CCTCGGCCTC GTCACGTGTT CAATATGCTA AAGAAGTATG TCCGCGCAGA ACAGAAGGAC
AGACAGCACA CCCTAAAGCA TTTCGAGCAT GTGCGCATGG TGGATCCCAA GAAAGCCGCT
CAGATCCGGT CCCAGGTTAT GACACACCTC CGTGTGATTT ATGAGCGCAT GAATCAGTCT
CTCTCCCTGC TCTACAACGT GCCTGCAGTG GCCGAGGAGA TTCAGGATGA AGTTGATGAG
CTGCTTCAGA AAGAGCAAAA CTATTCAGAT GACGTCTTGG CCAACATGAT TAGTGAACCA
AGGATCAGTT ACGGAAACGA TGCTCTCATG CCATCTTTGA CCGAAACGAA AACCACCGTG
GAGCTCCTTC CCGTGAATGG AGAGTTCAGC CTGGACGATC TCCAGCCGTG GCATTCTTTT
GGGGCTGACT CTGTGCCAGC CAACACAGAA AACGAAGTTG AGCCTGTTGA TGCCCGCCCT
GCTGCCGACC GAGGACTGAC CACTCGACCA GGTTCTGGGT TGACAAATAT CAAGACGGAG
GAGATCTCTG AAGTGAAGAT GGATGCAGAA TTCCGACATG ACTCAGGATA TGAAGTTCAT
CATCAAAAAT TGGTGTTCTT TGCAGAAGAT GTGGGTTCAA ACAAAGGTGC AATCATTGGA
CTCATGGTGG GCGGTGTTGT CATAGCGACA GTGATCGTCA TCACCTTGGT GATGCTGAAG
AAGAAACAGT ACACATCCAT TCATCATGGT GTGGTGGAGG TTGACGCCGC TGTCACCCCA
GAGGAGCGCC ACCTGTCCAA GATGCAGCAG AACGGCTACG AAAATCCAAC CTACAAGTTC
TTTGAGCAGA TGCAGAACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27184
Clone ID Related Accession (Same CDS sequence) NM_001136131
Accession Version NM_001136131.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1983bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform g
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK296229.1, Y00264.1 and BM876312.1. On Feb 24, 2011 this sequence version replaced gi:209915574. Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK296229.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTGTG GCAGACTGAA CATGCACATG AATGTCCAGA ATGGGAAGTG GGATTCAGAT 
CCATCAGGGA CCAAAACCTG CATTGATACC AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA
GTCTACCCTG AACTGCAGAT CACCAATGTG GTAGAAGCCA ACCAACCAGT GACCATCCAG
AACTGGTGCA AGCGGGGCCG CAAGCAGTGC AAGACCCATC CCCACTTTGT GATTCCCTAC
CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT GCCCTTCTCG TTCCTGACAA GTGCAAATTC
TTACACCAGG AGAGGATGGA TGTTTGCGAA ACTCATCTTC ACTGGCACAC CGTCGCCAAA
GAGACATGCA GTGAGAAGAG TACCAACTTG CATGACTACG GCATGTTGCT GCCCTGCGGA
ATTGACAAGT TCCGAGGGGT AGAGTTTGTG TGTTGCCCAC TGGCTGAAGA AAGTGACAAT
GTGGATTCTG CTGATGCGGA GGAGGATGAC TCGGATGTCT GGTGGGGCGG AGCAGACACA
GACTATGCAG ATGGGAGTGA AGACAAAGTA GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT
GAGGTGGAAG AAGAAGAAGC CGATGATGAC GAGGACGATG AGGATGGTGA TGAGGTAGAG
GAAGAGGCTG AGGAACCCTA CGAAGAAGCC ACAGAGAGAA CCACCAGCAT TGCCACCACC
ACCACCACCA CCACAGAGTC TGTGGAAGAG GTGGTTCGAG TTCCTACAAC AGCAGCCAGT
ACCCCTGATG CCGTTGACAA GTATCTCGAG ACACCTGGGG ATGAGAATGA ACATGCCCAT
TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC AAGCACCGAG AGAGAATGTC CCAGGTCATG
AGAGAATGGG AAGAGGCAGA ACGTCAAGCA AAGAACTTGC CTAAAGCTGA TAAGAAGGCA
GTTATCCAGC ATTTCCAGGA GAAAGTGGAA TCTTTGGAAC AGGAAGCAGC CAACGAGAGA
CAGCAGCTGG TGGAGACACA CATGGCCAGA GTGGAAGCCA TGCTCAATGA CCGCCGCCGC
CTGGCCCTGG AGAACTACAT CACCGCTCTG CAGGCTGTTC CTCCTCGGCC TCGTCACGTG
TTCAATATGC TAAAGAAGTA TGTCCGCGCA GAACAGAAGG ACAGACAGCA CACCCTAAAG
CATTTCGAGC ATGTGCGCAT GGTGGATCCC AAGAAAGCCG CTCAGATCCG GTCCCAGGTT
ATGACACACC TCCGTGTGAT TTATGAGCGC ATGAATCAGT CTCTCTCCCT GCTCTACAAC
GTGCCTGCAG TGGCCGAGGA GATTCAGGAT GAAGTTGATG AGCTGCTTCA GAAAGAGCAA
AACTATTCAG ATGACGTCTT GGCCAACATG ATTAGTGAAC CAAGGATCAG TTACGGAAAC
GATGCTCTCA TGCCATCTTT GACCGAAACG AAAACCACCG TGGAGCTCCT TCCCGTGAAT
GGAGAGTTCA GCCTGGACGA TCTCCAGCCG TGGCATTCTT TTGGGGCTGA CTCTGTGCCA
GCCAACACAG AAAACGAAGT TGAGCCTGTT GATGCCCGCC CTGCTGCCGA CCGAGGACTG
ACCACTCGAC CAGGTTCTGG GTTGACAAAT ATCAAGACGG AGGAGATCTC TGAAGTGAAG
ATGGATGCAG AATTCCGACA TGACTCAGGA TATGAAGTTC ATCATCAAAA ATTGGTGTTC
TTTGCAGAAG ATGTGGGTTC AAACAAAGGT GCAATCATTG GACTCATGGT GGGCGGTGTT
GTCATAGCGA CAGTGATCGT CATCACCTTG GTGATGCTGA AGAAGAAACA GTACACATCC
ATTCATCATG GTGTGGTGGA GGTTGACGCC GCTGTCACCC CAGAGGAGCG CCACCTGTCC
AAGATGCAGC AGAACGGCTA CGAAAATCCA ACCTACAAGT TCTTTGAGCA GATGCAGAAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001129603.1
CDS193..2175
Misc Feature(1)67..69(+)
Misc Feature(2)193..651(+)
Misc Feature(3)193..480(+)
Misc Feature(4)481..651(+)
Misc Feature(5)955..1509(+)
Misc Feature(6)1876..2001(+)
Misc Feature(7)2005..2160(+)
Exon (1)1..144
Gene:APP
Gene Synonym:
Exon (2)145..312
Gene:APP
Gene Synonym:
Exon (3)313..442
Gene:APP
Gene Synonym:
Exon (4)443..555
Gene:APP
Gene Synonym:
Exon (5)556..749
Gene:APP
Gene Synonym:
Exon (6)750..952
Gene:APP
Gene Synonym:
Exon (7)953..1086
Gene:APP
Gene Synonym:
Exon (8)1087..1161
Gene:APP
Gene Synonym:
Exon (9)1162..1320
Gene:APP
Gene Synonym:
Exon (10)1321..1449
Gene:APP
Gene Synonym:
Exon (11)1450..1549
Gene:APP
Gene Synonym:
Exon (12)1550..1771
Gene:APP
Gene Synonym:
Exon (13)1772..1825
Gene:APP
Gene Synonym:
Exon (14)1826..1926
Gene:APP
Gene Synonym:
Exon (15)1927..2073
Gene:APP
Gene Synonym:
Exon (16)2074..3295
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001136131
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136131

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTGTG GCAGACTGAA CATGCACATG AATGTCCAGA ATGGGAAGTG GGATTCAGAT 
CCATCAGGGA CCAAAACCTG CATTGATACC AAGGAAGGCA TCCTGCAGTA TTGCCAAGAA
GTCTACCCTG AACTGCAGAT CACCAATGTG GTAGAAGCCA ACCAACCAGT GACCATCCAG
AACTGGTGCA AGCGGGGCCG CAAGCAGTGC AAGACCCATC CCCACTTTGT GATTCCCTAC
CGCTGCTTAG TTGGTGAGTT TGTAAGTGAT GCCCTTCTCG TTCCTGACAA GTGCAAATTC
TTACACCAGG AGAGGATGGA TGTTTGCGAA ACTCATCTTC ACTGGCACAC CGTCGCCAAA
GAGACATGCA GTGAGAAGAG TACCAACTTG CATGACTACG GCATGTTGCT GCCCTGCGGA
ATTGACAAGT TCCGAGGGGT AGAGTTTGTG TGTTGCCCAC TGGCTGAAGA AAGTGACAAT
GTGGATTCTG CTGATGCGGA GGAGGATGAC TCGGATGTCT GGTGGGGCGG AGCAGACACA
GACTATGCAG ATGGGAGTGA AGACAAAGTA GTAGAAGTAG CAGAGGAGGA AGAAGTGGCT
GAGGTGGAAG AAGAAGAAGC CGATGATGAC GAGGACGATG AGGATGGTGA TGAGGTAGAG
GAAGAGGCTG AGGAACCCTA CGAAGAAGCC ACAGAGAGAA CCACCAGCAT TGCCACCACC
ACCACCACCA CCACAGAGTC TGTGGAAGAG GTGGTTCGAG TTCCTACAAC AGCAGCCAGT
ACCCCTGATG CCGTTGACAA GTATCTCGAG ACACCTGGGG ATGAGAATGA ACATGCCCAT
TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC AAGCACCGAG AGAGAATGTC CCAGGTCATG
AGAGAATGGG AAGAGGCAGA ACGTCAAGCA AAGAACTTGC CTAAAGCTGA TAAGAAGGCA
GTTATCCAGC ATTTCCAGGA GAAAGTGGAA TCTTTGGAAC AGGAAGCAGC CAACGAGAGA
CAGCAGCTGG TGGAGACACA CATGGCCAGA GTGGAAGCCA TGCTCAATGA CCGCCGCCGC
CTGGCCCTGG AGAACTACAT CACCGCTCTG CAGGCTGTTC CTCCTCGGCC TCGTCACGTG
TTCAATATGC TAAAGAAGTA TGTCCGCGCA GAACAGAAGG ACAGACAGCA CACCCTAAAG
CATTTCGAGC ATGTGCGCAT GGTGGATCCC AAGAAAGCCG CTCAGATCCG GTCCCAGGTT
ATGACACACC TCCGTGTGAT TTATGAGCGC ATGAATCAGT CTCTCTCCCT GCTCTACAAC
GTGCCTGCAG TGGCCGAGGA GATTCAGGAT GAAGTTGATG AGCTGCTTCA GAAAGAGCAA
AACTATTCAG ATGACGTCTT GGCCAACATG ATTAGTGAAC CAAGGATCAG TTACGGAAAC
GATGCTCTCA TGCCATCTTT GACCGAAACG AAAACCACCG TGGAGCTCCT TCCCGTGAAT
GGAGAGTTCA GCCTGGACGA TCTCCAGCCG TGGCATTCTT TTGGGGCTGA CTCTGTGCCA
GCCAACACAG AAAACGAAGT TGAGCCTGTT GATGCCCGCC CTGCTGCCGA CCGAGGACTG
ACCACTCGAC CAGGTTCTGG GTTGACAAAT ATCAAGACGG AGGAGATCTC TGAAGTGAAG
ATGGATGCAG AATTCCGACA TGACTCAGGA TATGAAGTTC ATCATCAAAA ATTGGTGTTC
TTTGCAGAAG ATGTGGGTTC AAACAAAGGT GCAATCATTG GACTCATGGT GGGCGGTGTT
GTCATAGCGA CAGTGATCGT CATCACCTTG GTGATGCTGA AGAAGAAACA GTACACATCC
ATTCATCATG GTGTGGTGGA GGTTGACGCC GCTGTCACCC CAGAGGAGCG CCACCTGTCC
AAGATGCAGC AGAACGGCTA CGAAAATCCA ACCTACAAGT TCTTTGAGCA GATGCAGAAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27406
Clone ID Related Accession (Same CDS sequence) NM_001136130
Accession Version NM_001136130.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2145bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform f precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AK294534.1, BC065523.1, BC065529.1 and BM876312.1. On Apr 29, 2009 this sequence version replaced gi:209915572. Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK294534.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTC 
TACCCTGAAC TGCAGATCAC CAATGTGGTA GAAGCCAACC AACCAGTGAC CATCCAGAAC
TGGTGCAAGC GGGGCCGCAA GCAGTGCAAG ACCCATCCCC ACTTTGTGAT TCCCTACCGC
TGCTTAGTTG GTGAGTTTGT AAGTGATGCC CTTCTCGTTC CTGACAAGTG CAAATTCTTA
CACCAGGAGA GGATGGATGT TTGCGAAACT CATCTTCACT GGCACACCGT CGCCAAAGAG
ACATGCAGTG AGAAGAGTAC CAACTTGCAT GACTACGGCA TGTTGCTGCC CTGCGGAATT
GACAAGTTCC GAGGGGTAGA GTTTGTGTGT TGCCCACTGG CTGAAGAAAG TGACAATGTG
GATTCTGCTG ATGCGGAGGA GGATGACTCG GATGTCTGGT GGGGCGGAGC AGACACAGAC
TATGCAGATG GGAGTGAAGA CAAAGTAGTA GAAGTAGCAG AGGAGGAAGA AGTGGCTGAG
GTGGAAGAAG AAGAAGCCGA TGATGACGAG GACGATGAGG ATGGTGATGA GGTAGAGGAA
GAGGCTGAGG AACCCTACGA AGAAGCCACA GAGAGAACCA CCAGCATTGC CACCACCACC
ACCACCACCA CAGAGTCTGT GGAAGAGGTG GTTCGAGAGG TGTGCTCTGA ACAAGCCGAG
ACGGGGCCGT GCCGAGCAAT GATCTCCCGC TGGTACTTTG ATGTGACTGA AGGGAAGTGT
GCCCCATTCT TTTACGGCGG ATGTGGCGGC AACCGGAACA ACTTTGACAC AGAAGAGTAC
TGCATGGCCG TGTGTGGCAG CGCCATGTCC CAAAGTTTAC TCAAGACTAC CCAGGAACCT
CTTGCCCGAG ATCCTGTTAA ACTTCCTACA ACAGCAGCCA GTACCCCTGA TGCCGTTGAC
AAGTATCTCG AGACACCTGG GGATGAGAAT GAACATGCCC ATTTCCAGAA AGCCAAAGAG
AGGCTTGAGG CCAAGCACCG AGAGAGAATG TCCCAGGTCA TGAGAGAATG GGAAGAGGCA
GAACGTCAAG CAAAGAACTT GCCTAAAGCT GATAAGAAGG CAGTTATCCA GCATTTCCAG
GAGAAAGTGG AATCTTTGGA ACAGGAAGCA GCCAACGAGA GACAGCAGCT GGTGGAGACA
CACATGGCCA GAGTGGAAGC CATGCTCAAT GACCGCCGCC GCCTGGCCCT GGAGAACTAC
ATCACCGCTC TGCAGGCTGT TCCTCCTCGG CCTCGTCACG TGTTCAATAT GCTAAAGAAG
TATGTCCGCG CAGAACAGAA GGACAGACAG CACACCCTAA AGCATTTCGA GCATGTGCGC
ATGGTGGATC CCAAGAAAGC CGCTCAGATC CGGTCCCAGG TTATGACACA CCTCCGTGTG
ATTTATGAGC GCATGAATCA GTCTCTCTCC CTGCTCTACA ACGTGCCTGC AGTGGCCGAG
GAGATTCAGG ATGAAGTTGA TGAGCTGCTT CAGAAAGAGC AAAACTATTC AGATGACGTC
TTGGCCAACA TGATTAGTGA ACCAAGGATC AGTTACGGAA ACGATGCTCT CATGCCATCT
TTGACCGAAA CGAAAACCAC CGTGGAGCTC CTTCCCGTGA ATGGAGAGTT CAGCCTGGAC
GATCTCCAGC CGTGGCATTC TTTTGGGGCT GACTCTGTGC CAGCCAACAC AGAAAACGAA
GTTGAGCCTG TTGATGCCCG CCCTGCTGCC GACCGAGGAC TGACCACTCG ACCAGGTTCT
GGGTTGACAA ATATCAAGAC GGAGGAGATC TCTGAAGTGA AGATGGATGC AGAATTCCGA
CATGACTCAG GATATGAAGT TCATCATCAA AAATTGGTGT TCTTTGCAGA AGATGTGGGT
TCAAACAAAG GTGCAATCAT TGGACTCATG GTGGGCGGTG TTGTCATAGC GACAGTGATC
GTCATCACCT TGGTGATGCT GAAGAAGAAA CAGTACACAT CCATTCATCA TGGTGTGGTG
GAGGTTGACG CCGCTGTCAC CCCAGAGGAG CGCCACCTGT CCAAGATGCA GCAGAACGGC
TACGAAAATC CAACCTACAA GTTCTTTGAG CAGATGCAGA ACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001129602.1
CDS201..2345
Misc Feature(1)24..26(+)
Misc Feature(2)255..425(+)
Misc Feature(3)426..596(+)
Misc Feature(4)915..1058(+)
Misc Feature(5)927..947(+)
Misc Feature(6)1125..1679(+)
Misc Feature(7)2046..2171(+)
Misc Feature(8)2175..2330(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..387
Gene:APP
Gene Synonym:
Exon (3)388..500
Gene:APP
Gene Synonym:
Exon (4)501..694
Gene:APP
Gene Synonym:
Exon (5)695..897
Gene:APP
Gene Synonym:
Exon (6)898..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1122
Gene:APP
Gene Synonym:
Exon (8)1123..1256
Gene:APP
Gene Synonym:
Exon (9)1257..1331
Gene:APP
Gene Synonym:
Exon (10)1332..1490
Gene:APP
Gene Synonym:
Exon (11)1491..1619
Gene:APP
Gene Synonym:
Exon (12)1620..1719
Gene:APP
Gene Synonym:
Exon (13)1720..1941
Gene:APP
Gene Synonym:
Exon (14)1942..1995
Gene:APP
Gene Synonym:
Exon (15)1996..2096
Gene:APP
Gene Synonym:
Exon (16)2097..2243
Gene:APP
Gene Synonym:
Exon (17)2244..3465
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001136130
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136130

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTC 
TACCCTGAAC TGCAGATCAC CAATGTGGTA GAAGCCAACC AACCAGTGAC CATCCAGAAC
TGGTGCAAGC GGGGCCGCAA GCAGTGCAAG ACCCATCCCC ACTTTGTGAT TCCCTACCGC
TGCTTAGTTG GTGAGTTTGT AAGTGATGCC CTTCTCGTTC CTGACAAGTG CAAATTCTTA
CACCAGGAGA GGATGGATGT TTGCGAAACT CATCTTCACT GGCACACCGT CGCCAAAGAG
ACATGCAGTG AGAAGAGTAC CAACTTGCAT GACTACGGCA TGTTGCTGCC CTGCGGAATT
GACAAGTTCC GAGGGGTAGA GTTTGTGTGT TGCCCACTGG CTGAAGAAAG TGACAATGTG
GATTCTGCTG ATGCGGAGGA GGATGACTCG GATGTCTGGT GGGGCGGAGC AGACACAGAC
TATGCAGATG GGAGTGAAGA CAAAGTAGTA GAAGTAGCAG AGGAGGAAGA AGTGGCTGAG
GTGGAAGAAG AAGAAGCCGA TGATGACGAG GACGATGAGG ATGGTGATGA GGTAGAGGAA
GAGGCTGAGG AACCCTACGA AGAAGCCACA GAGAGAACCA CCAGCATTGC CACCACCACC
ACCACCACCA CAGAGTCTGT GGAAGAGGTG GTTCGAGAGG TGTGCTCTGA ACAAGCCGAG
ACGGGGCCGT GCCGAGCAAT GATCTCCCGC TGGTACTTTG ATGTGACTGA AGGGAAGTGT
GCCCCATTCT TTTACGGCGG ATGTGGCGGC AACCGGAACA ACTTTGACAC AGAAGAGTAC
TGCATGGCCG TGTGTGGCAG CGCCATGTCC CAAAGTTTAC TCAAGACTAC CCAGGAACCT
CTTGCCCGAG ATCCTGTTAA ACTTCCTACA ACAGCAGCCA GTACCCCTGA TGCCGTTGAC
AAGTATCTCG AGACACCTGG GGATGAGAAT GAACATGCCC ATTTCCAGAA AGCCAAAGAG
AGGCTTGAGG CCAAGCACCG AGAGAGAATG TCCCAGGTCA TGAGAGAATG GGAAGAGGCA
GAACGTCAAG CAAAGAACTT GCCTAAAGCT GATAAGAAGG CAGTTATCCA GCATTTCCAG
GAGAAAGTGG AATCTTTGGA ACAGGAAGCA GCCAACGAGA GACAGCAGCT GGTGGAGACA
CACATGGCCA GAGTGGAAGC CATGCTCAAT GACCGCCGCC GCCTGGCCCT GGAGAACTAC
ATCACCGCTC TGCAGGCTGT TCCTCCTCGG CCTCGTCACG TGTTCAATAT GCTAAAGAAG
TATGTCCGCG CAGAACAGAA GGACAGACAG CACACCCTAA AGCATTTCGA GCATGTGCGC
ATGGTGGATC CCAAGAAAGC CGCTCAGATC CGGTCCCAGG TTATGACACA CCTCCGTGTG
ATTTATGAGC GCATGAATCA GTCTCTCTCC CTGCTCTACA ACGTGCCTGC AGTGGCCGAG
GAGATTCAGG ATGAAGTTGA TGAGCTGCTT CAGAAAGAGC AAAACTATTC AGATGACGTC
TTGGCCAACA TGATTAGTGA ACCAAGGATC AGTTACGGAA ACGATGCTCT CATGCCATCT
TTGACCGAAA CGAAAACCAC CGTGGAGCTC CTTCCCGTGA ATGGAGAGTT CAGCCTGGAC
GATCTCCAGC CGTGGCATTC TTTTGGGGCT GACTCTGTGC CAGCCAACAC AGAAAACGAA
GTTGAGCCTG TTGATGCCCG CCCTGCTGCC GACCGAGGAC TGACCACTCG ACCAGGTTCT
GGGTTGACAA ATATCAAGAC GGAGGAGATC TCTGAAGTGA AGATGGATGC AGAATTCCGA
CATGACTCAG GATATGAAGT TCATCATCAA AAATTGGTGT TCTTTGCAGA AGATGTGGGT
TCAAACAAAG GTGCAATCAT TGGACTCATG GTGGGCGGTG TTGTCATAGC GACAGTGATC
GTCATCACCT TGGTGATGCT GAAGAAGAAA CAGTACACAT CCATTCATCA TGGTGTGGTG
GAGGTTGACG CCGCTGTCAC CCCAGAGGAG CGCCACCTGT CCAAGATGCA GCAGAACGGC
TACGAAAATC CAACCTACAA GTTCTTTGAG CAGATGCAGA ACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27126
Clone ID Related Accession (Same CDS sequence) NM_001136129
Accession Version NM_001136129.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1920bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform e precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AF282245.1, BC065529.1 and BM876312.1. On Apr 29, 2009 this sequence version replaced gi:209915569. Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AF282245.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTC 
TACCCTGAAC TGCAGATCAC CAATGTGGTA GAAGCCAACC AACCAGTGAC CATCCAGAAC
TGGTGCAAGC GGGGCCGCAA GCAGTGCAAG ACCCATCCCC ACTTTGTGAT TCCCTACCGC
TGCTTAGTTG GTGAGTTTGT AAGTGATGCC CTTCTCGTTC CTGACAAGTG CAAATTCTTA
CACCAGGAGA GGATGGATGT TTGCGAAACT CATCTTCACT GGCACACCGT CGCCAAAGAG
ACATGCAGTG AGAAGAGTAC CAACTTGCAT GACTACGGCA TGTTGCTGCC CTGCGGAATT
GACAAGTTCC GAGGGGTAGA GTTTGTGTGT TGCCCACTGG CTGAAGAAAG TGACAATGTG
GATTCTGCTG ATGCGGAGGA GGATGACTCG GATGTCTGGT GGGGCGGAGC AGACACAGAC
TATGCAGATG GGAGTGAAGA CAAAGTAGTA GAAGTAGCAG AGGAGGAAGA AGTGGCTGAG
GTGGAAGAAG AAGAAGCCGA TGATGACGAG GACGATGAGG ATGGTGATGA GGTAGAGGAA
GAGGCTGAGG AACCCTACGA AGAAGCCACA GAGAGAACCA CCAGCATTGC CACCACCACC
ACCACCACCA CAGAGTCTGT GGAAGAGGTG GTTCGAGTTC CTACAACAGC AGCCAGTACC
CCTGATGCCG TTGACAAGTA TCTCGAGACA CCTGGGGATG AGAATGAACA TGCCCATTTC
CAGAAAGCCA AAGAGAGGCT TGAGGCCAAG CACCGAGAGA GAATGTCCCA GGTCATGAGA
GAATGGGAAG AGGCAGAACG TCAAGCAAAG AACTTGCCTA AAGCTGATAA GAAGGCAGTT
ATCCAGCATT TCCAGGAGAA AGTGGAATCT TTGGAACAGG AAGCAGCCAA CGAGAGACAG
CAGCTGGTGG AGACACACAT GGCCAGAGTG GAAGCCATGC TCAATGACCG CCGCCGCCTG
GCCCTGGAGA ACTACATCAC CGCTCTGCAG GCTGTTCCTC CTCGGCCTCG TCACGTGTTC
AATATGCTAA AGAAGTATGT CCGCGCAGAA CAGAAGGACA GACAGCACAC CCTAAAGCAT
TTCGAGCATG TGCGCATGGT GGATCCCAAG AAAGCCGCTC AGATCCGGTC CCAGGTTATG
ACACACCTCC GTGTGATTTA TGAGCGCATG AATCAGTCTC TCTCCCTGCT CTACAACGTG
CCTGCAGTGG CCGAGGAGAT TCAGGATGAA GTTGATGAGC TGCTTCAGAA AGAGCAAAAC
TATTCAGATG ACGTCTTGGC CAACATGATT AGTGAACCAA GGATCAGTTA CGGAAACGAT
GCTCTCATGC CATCTTTGAC CGAAACGAAA ACCACCGTGG AGCTCCTTCC CGTGAATGGA
GAGTTCAGCC TGGACGATCT CCAGCCGTGG CATTCTTTTG GGGCTGACTC TGTGCCAGCC
AACACAGAAA ACGAAGTTGA GCCTGTTGAT GCCCGCCCTG CTGCCGACCG AGGACTGACC
ACTCGACCAG GTTCTGGGTT GACAAATATC AAGACGGAGG AGATCTCTGA AGTGAAGATG
GATGCAGAAT TCCGACATGA CTCAGGATAT GAAGTTCATC ATCAAAAATT GGTGTTCTTT
GCAGAAGATG TGGGTTCAAA CAAAGGTGCA ATCATTGGAC TCATGGTGGG CGGTGTTGTC
ATAGCGACAG TGATCGTCAT CACCTTGGTG ATGCTGAAGA AGAAACAGTA CACATCCATT
CATCATGGTG TGGTGGAGGT TGACGCCGCT GTCACCCCAG AGGAGCGCCA CCTGTCCAAG
ATGCAGCAGA ACGGCTACGA AAATCCAACC TACAAGTTCT TTGAGCAGAT GCAGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001129601.1
CDS201..2120
Misc Feature(1)24..26(+)
Misc Feature(2)255..425(+)
Misc Feature(3)426..596(+)
Misc Feature(4)900..1454(+)
Misc Feature(5)1821..1946(+)
Misc Feature(6)1950..2105(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..387
Gene:APP
Gene Synonym:
Exon (3)388..500
Gene:APP
Gene Synonym:
Exon (4)501..694
Gene:APP
Gene Synonym:
Exon (5)695..897
Gene:APP
Gene Synonym:
Exon (6)898..1031
Gene:APP
Gene Synonym:
Exon (7)1032..1106
Gene:APP
Gene Synonym:
Exon (8)1107..1265
Gene:APP
Gene Synonym:
Exon (9)1266..1394
Gene:APP
Gene Synonym:
Exon (10)1395..1494
Gene:APP
Gene Synonym:
Exon (11)1495..1716
Gene:APP
Gene Synonym:
Exon (12)1717..1770
Gene:APP
Gene Synonym:
Exon (13)1771..1871
Gene:APP
Gene Synonym:
Exon (14)1872..2018
Gene:APP
Gene Synonym:
Exon (15)2019..3240
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001136129
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001136129

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTC 
TACCCTGAAC TGCAGATCAC CAATGTGGTA GAAGCCAACC AACCAGTGAC CATCCAGAAC
TGGTGCAAGC GGGGCCGCAA GCAGTGCAAG ACCCATCCCC ACTTTGTGAT TCCCTACCGC
TGCTTAGTTG GTGAGTTTGT AAGTGATGCC CTTCTCGTTC CTGACAAGTG CAAATTCTTA
CACCAGGAGA GGATGGATGT TTGCGAAACT CATCTTCACT GGCACACCGT CGCCAAAGAG
ACATGCAGTG AGAAGAGTAC CAACTTGCAT GACTACGGCA TGTTGCTGCC CTGCGGAATT
GACAAGTTCC GAGGGGTAGA GTTTGTGTGT TGCCCACTGG CTGAAGAAAG TGACAATGTG
GATTCTGCTG ATGCGGAGGA GGATGACTCG GATGTCTGGT GGGGCGGAGC AGACACAGAC
TATGCAGATG GGAGTGAAGA CAAAGTAGTA GAAGTAGCAG AGGAGGAAGA AGTGGCTGAG
GTGGAAGAAG AAGAAGCCGA TGATGACGAG GACGATGAGG ATGGTGATGA GGTAGAGGAA
GAGGCTGAGG AACCCTACGA AGAAGCCACA GAGAGAACCA CCAGCATTGC CACCACCACC
ACCACCACCA CAGAGTCTGT GGAAGAGGTG GTTCGAGTTC CTACAACAGC AGCCAGTACC
CCTGATGCCG TTGACAAGTA TCTCGAGACA CCTGGGGATG AGAATGAACA TGCCCATTTC
CAGAAAGCCA AAGAGAGGCT TGAGGCCAAG CACCGAGAGA GAATGTCCCA GGTCATGAGA
GAATGGGAAG AGGCAGAACG TCAAGCAAAG AACTTGCCTA AAGCTGATAA GAAGGCAGTT
ATCCAGCATT TCCAGGAGAA AGTGGAATCT TTGGAACAGG AAGCAGCCAA CGAGAGACAG
CAGCTGGTGG AGACACACAT GGCCAGAGTG GAAGCCATGC TCAATGACCG CCGCCGCCTG
GCCCTGGAGA ACTACATCAC CGCTCTGCAG GCTGTTCCTC CTCGGCCTCG TCACGTGTTC
AATATGCTAA AGAAGTATGT CCGCGCAGAA CAGAAGGACA GACAGCACAC CCTAAAGCAT
TTCGAGCATG TGCGCATGGT GGATCCCAAG AAAGCCGCTC AGATCCGGTC CCAGGTTATG
ACACACCTCC GTGTGATTTA TGAGCGCATG AATCAGTCTC TCTCCCTGCT CTACAACGTG
CCTGCAGTGG CCGAGGAGAT TCAGGATGAA GTTGATGAGC TGCTTCAGAA AGAGCAAAAC
TATTCAGATG ACGTCTTGGC CAACATGATT AGTGAACCAA GGATCAGTTA CGGAAACGAT
GCTCTCATGC CATCTTTGAC CGAAACGAAA ACCACCGTGG AGCTCCTTCC CGTGAATGGA
GAGTTCAGCC TGGACGATCT CCAGCCGTGG CATTCTTTTG GGGCTGACTC TGTGCCAGCC
AACACAGAAA ACGAAGTTGA GCCTGTTGAT GCCCGCCCTG CTGCCGACCG AGGACTGACC
ACTCGACCAG GTTCTGGGTT GACAAATATC AAGACGGAGG AGATCTCTGA AGTGAAGATG
GATGCAGAAT TCCGACATGA CTCAGGATAT GAAGTTCATC ATCAAAAATT GGTGTTCTTT
GCAGAAGATG TGGGTTCAAA CAAAGGTGCA ATCATTGGAC TCATGGTGGG CGGTGTTGTC
ATAGCGACAG TGATCGTCAT CACCTTGGTG ATGCTGAAGA AGAAACAGTA CACATCCATT
CATCATGGTG TGGTGGAGGT TGACGCCGCT GTCACCCCAG AGGAGCGCCA CCTGTCCAAG
ATGCAGCAGA ACGGCTACGA AAATCCAACC TACAAGTTCT TTGAGCAGAT GCAGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27259
Clone ID Related Accession (Same CDS sequence) NM_000484
Accession Version NM_000484.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2313bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform a precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, AK312326.1, BC065529.1 and BM876312.1. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2009 this sequence version replaced gi:41406053. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as PreA4 770). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AK312326.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGT TGAGCCTGTT
GATGCCCGCC CTGCTGCCGA CCGAGGACTG ACCACTCGAC CAGGTTCTGG GTTGACAAAT
ATCAAGACGG AGGAGATCTC TGAAGTGAAG ATGGATGCAG AATTCCGACA TGACTCAGGA
TATGAAGTTC ATCATCAAAA ATTGGTGTTC TTTGCAGAAG ATGTGGGTTC AAACAAAGGT
GCAATCATTG GACTCATGGT GGGCGGTGTT GTCATAGCGA CAGTGATCGT CATCACCTTG
GTGATGCTGA AGAAGAAACA GTACACATCC ATTCATCATG GTGTGGTGGA GGTTGACGCC
GCTGTCACCC CAGAGGAGCG CCACCTGTCC AAGATGCAGC AGAACGGCTA CGAAAATCCA
ACCTACAAGT TCTTTGAGCA GATGCAGAAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000475.1
CDS201..2513
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)486..530(+)
Misc Feature(5)594..764(+)
Misc Feature(6)630..632(+)
Misc Feature(7)741..764(+)
Misc Feature(8)792..794(+)
Misc Feature(9)816..818(+)
Misc Feature(10)1083..1226(+)
Misc Feature(11)1095..1115(+)
Misc Feature(12)1101..1106(+)
Misc Feature(13)1293..1847(+)
Misc Feature(14)1371..1469(+)
Misc Feature(15)1671..1766(+)
Misc Feature(16)1767..1820(+)
Misc Feature(17)2202..2204(+)
Misc Feature(18)2211..2216(+)
Misc Feature(19)2214..2339(+)
Misc Feature(20)2214..2219(+)
Misc Feature(21)2214..2216(+)
Misc Feature(22)2214..2216(+)
Misc Feature(23)2220..2222(+)
Misc Feature(24)2259..2264(+)
Misc Feature(25)2268..2273(+)
Misc Feature(26)2268..2270(+)
Misc Feature(27)2268..2270(+)
Misc Feature(28)2271..2273(+)
Misc Feature(29)2271..2273(+)
Misc Feature(30)2298..2369(+)
Misc Feature(31)2310..2312(+)
Misc Feature(32)2313..2315(+)
Misc Feature(33)2316..2318(+)
Misc Feature(34)2331..2336(+)
Misc Feature(35)2337..2342(+)
Misc Feature(36)2337..2339(+)
Misc Feature(37)2340..2342(+)
Misc Feature(38)2343..2498(+)
Misc Feature(39)2355..2357(+)
Misc Feature(40)2358..2363(+)
Misc Feature(41)2358..2360(+)
Misc Feature(42)2370..2402(+)
Misc Feature(43)2394..2453(+)
Misc Feature(44)2415..2420(+)
Misc Feature(45)2415..2417(+)
Misc Feature(46)2427..2429(+)
Misc Feature(47)2427..2429(+)
Misc Feature(48)2427..2429(+)
Misc Feature(49)2469..2471(+)
Misc Feature(50)2469..2471(+)
Misc Feature(51)2475..2486(+)
Misc Feature(52)2484..2486(+)
Misc Feature(53)2490..2492(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1233
Gene:APP
Gene Synonym:
Exon (8)1234..1290
Gene:APP
Gene Synonym:
Exon (9)1291..1424
Gene:APP
Gene Synonym:
Exon (10)1425..1499
Gene:APP
Gene Synonym:
Exon (11)1500..1658
Gene:APP
Gene Synonym:
Exon (12)1659..1787
Gene:APP
Gene Synonym:
Exon (13)1788..1887
Gene:APP
Gene Synonym:
Exon (14)1888..2109
Gene:APP
Gene Synonym:
Exon (15)2110..2163
Gene:APP
Gene Synonym:
Exon (16)2164..2264
Gene:APP
Gene Synonym:
Exon (17)2265..2411
Gene:APP
Gene Synonym:
Exon (18)2412..3633
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000484
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000484

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATGTCCCA AAGTTTACTC AAGACTACCC AGGAACCTCT TGCCCGAGAT
CCTGTTAAAC TTCCTACAAC AGCAGCCAGT ACCCCTGATG CCGTTGACAA GTATCTCGAG
ACACCTGGGG ATGAGAATGA ACATGCCCAT TTCCAGAAAG CCAAAGAGAG GCTTGAGGCC
AAGCACCGAG AGAGAATGTC CCAGGTCATG AGAGAATGGG AAGAGGCAGA ACGTCAAGCA
AAGAACTTGC CTAAAGCTGA TAAGAAGGCA GTTATCCAGC ATTTCCAGGA GAAAGTGGAA
TCTTTGGAAC AGGAAGCAGC CAACGAGAGA CAGCAGCTGG TGGAGACACA CATGGCCAGA
GTGGAAGCCA TGCTCAATGA CCGCCGCCGC CTGGCCCTGG AGAACTACAT CACCGCTCTG
CAGGCTGTTC CTCCTCGGCC TCGTCACGTG TTCAATATGC TAAAGAAGTA TGTCCGCGCA
GAACAGAAGG ACAGACAGCA CACCCTAAAG CATTTCGAGC ATGTGCGCAT GGTGGATCCC
AAGAAAGCCG CTCAGATCCG GTCCCAGGTT ATGACACACC TCCGTGTGAT TTATGAGCGC
ATGAATCAGT CTCTCTCCCT GCTCTACAAC GTGCCTGCAG TGGCCGAGGA GATTCAGGAT
GAAGTTGATG AGCTGCTTCA GAAAGAGCAA AACTATTCAG ATGACGTCTT GGCCAACATG
ATTAGTGAAC CAAGGATCAG TTACGGAAAC GATGCTCTCA TGCCATCTTT GACCGAAACG
AAAACCACCG TGGAGCTCCT TCCCGTGAAT GGAGAGTTCA GCCTGGACGA TCTCCAGCCG
TGGCATTCTT TTGGGGCTGA CTCTGTGCCA GCCAACACAG AAAACGAAGT TGAGCCTGTT
GATGCCCGCC CTGCTGCCGA CCGAGGACTG ACCACTCGAC CAGGTTCTGG GTTGACAAAT
ATCAAGACGG AGGAGATCTC TGAAGTGAAG ATGGATGCAG AATTCCGACA TGACTCAGGA
TATGAAGTTC ATCATCAAAA ATTGGTGTTC TTTGCAGAAG ATGTGGGTTC AAACAAAGGT
GCAATCATTG GACTCATGGT GGGCGGTGTT GTCATAGCGA CAGTGATCGT CATCACCTTG
GTGATGCTGA AGAAGAAACA GTACACATCC ATTCATCATG GTGTGGTGGA GGTTGACGCC
GCTGTCACCC CAGAGGAGCG CCACCTGTCC AAGATGCAGC AGAACGGCTA CGAAAATCCA
ACCTACAAGT TCTTTGAGCA GATGCAGAAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26762
Clone ID Related Accession (Same CDS sequence) NM_201413
Accession Version NM_201413.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2256bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform b precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, BC065529.1 and BM876312.1. On Apr 29, 2009 this sequence version replaced gi:41406054. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as PreA4 751) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC065529.1, X06989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATTCCTAC AACAGCAGCC AGTACCCCTG ATGCCGTTGA CAAGTATCTC
GAGACACCTG GGGATGAGAA TGAACATGCC CATTTCCAGA AAGCCAAAGA GAGGCTTGAG
GCCAAGCACC GAGAGAGAAT GTCCCAGGTC ATGAGAGAAT GGGAAGAGGC AGAACGTCAA
GCAAAGAACT TGCCTAAAGC TGATAAGAAG GCAGTTATCC AGCATTTCCA GGAGAAAGTG
GAATCTTTGG AACAGGAAGC AGCCAACGAG AGACAGCAGC TGGTGGAGAC ACACATGGCC
AGAGTGGAAG CCATGCTCAA TGACCGCCGC CGCCTGGCCC TGGAGAACTA CATCACCGCT
CTGCAGGCTG TTCCTCCTCG GCCTCGTCAC GTGTTCAATA TGCTAAAGAA GTATGTCCGC
GCAGAACAGA AGGACAGACA GCACACCCTA AAGCATTTCG AGCATGTGCG CATGGTGGAT
CCCAAGAAAG CCGCTCAGAT CCGGTCCCAG GTTATGACAC ACCTCCGTGT GATTTATGAG
CGCATGAATC AGTCTCTCTC CCTGCTCTAC AACGTGCCTG CAGTGGCCGA GGAGATTCAG
GATGAAGTTG ATGAGCTGCT TCAGAAAGAG CAAAACTATT CAGATGACGT CTTGGCCAAC
ATGATTAGTG AACCAAGGAT CAGTTACGGA AACGATGCTC TCATGCCATC TTTGACCGAA
ACGAAAACCA CCGTGGAGCT CCTTCCCGTG AATGGAGAGT TCAGCCTGGA CGATCTCCAG
CCGTGGCATT CTTTTGGGGC TGACTCTGTG CCAGCCAACA CAGAAAACGA AGTTGAGCCT
GTTGATGCCC GCCCTGCTGC CGACCGAGGA CTGACCACTC GACCAGGTTC TGGGTTGACA
AATATCAAGA CGGAGGAGAT CTCTGAAGTG AAGATGGATG CAGAATTCCG ACATGACTCA
GGATATGAAG TTCATCATCA AAAATTGGTG TTCTTTGCAG AAGATGTGGG TTCAAACAAA
GGTGCAATCA TTGGACTCAT GGTGGGCGGT GTTGTCATAG CGACAGTGAT CGTCATCACC
TTGGTGATGC TGAAGAAGAA ACAGTACACA TCCATTCATC ATGGTGTGGT GGAGGTTGAC
GCCGCTGTCA CCCCAGAGGA GCGCCACCTG TCCAAGATGC AGCAGAACGG CTACGAAAAT
CCAACCTACA AGTTCTTTGA GCAGATGCAG AACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_958816.1
CDS201..2456
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)594..764(+)
Misc Feature(5)1083..1226(+)
Misc Feature(6)1095..1115(+)
Misc Feature(7)1236..1790(+)
Misc Feature(8)2145..2147(+)
Misc Feature(9)2157..2282(+)
Misc Feature(10)2157..2159(+)
Misc Feature(11)2157..2159(+)
Misc Feature(12)2163..2165(+)
Misc Feature(13)2211..2213(+)
Misc Feature(14)2214..2216(+)
Misc Feature(15)2214..2216(+)
Misc Feature(16)2256..2258(+)
Misc Feature(17)2280..2282(+)
Misc Feature(18)2283..2285(+)
Misc Feature(19)2286..2441(+)
Misc Feature(20)2298..2300(+)
Misc Feature(21)2301..2303(+)
Misc Feature(22)2358..2360(+)
Misc Feature(23)2358..2360(+)
Misc Feature(24)2370..2372(+)
Misc Feature(25)2370..2372(+)
Misc Feature(26)2412..2414(+)
Misc Feature(27)2427..2429(+)
Misc Feature(28)2433..2435(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1233
Gene:APP
Gene Synonym:
Exon (8)1234..1367
Gene:APP
Gene Synonym:
Exon (9)1368..1442
Gene:APP
Gene Synonym:
Exon (10)1443..1601
Gene:APP
Gene Synonym:
Exon (11)1602..1730
Gene:APP
Gene Synonym:
Exon (12)1731..1830
Gene:APP
Gene Synonym:
Exon (13)1831..2052
Gene:APP
Gene Synonym:
Exon (14)2053..2106
Gene:APP
Gene Synonym:
Exon (15)2107..2207
Gene:APP
Gene Synonym:
Exon (16)2208..2354
Gene:APP
Gene Synonym:
Exon (17)2355..3576
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_201413
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_201413

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATTCCTAC AACAGCAGCC AGTACCCCTG ATGCCGTTGA CAAGTATCTC
GAGACACCTG GGGATGAGAA TGAACATGCC CATTTCCAGA AAGCCAAAGA GAGGCTTGAG
GCCAAGCACC GAGAGAGAAT GTCCCAGGTC ATGAGAGAAT GGGAAGAGGC AGAACGTCAA
GCAAAGAACT TGCCTAAAGC TGATAAGAAG GCAGTTATCC AGCATTTCCA GGAGAAAGTG
GAATCTTTGG AACAGGAAGC AGCCAACGAG AGACAGCAGC TGGTGGAGAC ACACATGGCC
AGAGTGGAAG CCATGCTCAA TGACCGCCGC CGCCTGGCCC TGGAGAACTA CATCACCGCT
CTGCAGGCTG TTCCTCCTCG GCCTCGTCAC GTGTTCAATA TGCTAAAGAA GTATGTCCGC
GCAGAACAGA AGGACAGACA GCACACCCTA AAGCATTTCG AGCATGTGCG CATGGTGGAT
CCCAAGAAAG CCGCTCAGAT CCGGTCCCAG GTTATGACAC ACCTCCGTGT GATTTATGAG
CGCATGAATC AGTCTCTCTC CCTGCTCTAC AACGTGCCTG CAGTGGCCGA GGAGATTCAG
GATGAAGTTG ATGAGCTGCT TCAGAAAGAG CAAAACTATT CAGATGACGT CTTGGCCAAC
ATGATTAGTG AACCAAGGAT CAGTTACGGA AACGATGCTC TCATGCCATC TTTGACCGAA
ACGAAAACCA CCGTGGAGCT CCTTCCCGTG AATGGAGAGT TCAGCCTGGA CGATCTCCAG
CCGTGGCATT CTTTTGGGGC TGACTCTGTG CCAGCCAACA CAGAAAACGA AGTTGAGCCT
GTTGATGCCC GCCCTGCTGC CGACCGAGGA CTGACCACTC GACCAGGTTC TGGGTTGACA
AATATCAAGA CGGAGGAGAT CTCTGAAGTG AAGATGGATG CAGAATTCCG ACATGACTCA
GGATATGAAG TTCATCATCA AAAATTGGTG TTCTTTGCAG AAGATGTGGG TTCAAACAAA
GGTGCAATCA TTGGACTCAT GGTGGGCGGT GTTGTCATAG CGACAGTGAT CGTCATCACC
TTGGTGATGC TGAAGAAGAA ACAGTACACA TCCATTCATC ATGGTGTGGT GGAGGTTGAC
GCCGCTGTCA CCCCAGAGGA GCGCCACCTG TCCAAGATGC AGCAGAACGG CTACGAAAAT
CCAACCTACA AGTTCTTTGA GCAGATGCAG AACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26689
Clone ID Related Accession (Same CDS sequence) NM_201414
Accession Version NM_201414.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2088bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform c precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, Y00264.1 and BM876312.1. On Apr 29, 2009 this sequence version replaced gi:41406056. Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as PreA4 695) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: Y00264.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGTTCCT ACAACAGCAG CCAGTACCCC TGATGCCGTT
GACAAGTATC TCGAGACACC TGGGGATGAG AATGAACATG CCCATTTCCA GAAAGCCAAA
GAGAGGCTTG AGGCCAAGCA CCGAGAGAGA ATGTCCCAGG TCATGAGAGA ATGGGAAGAG
GCAGAACGTC AAGCAAAGAA CTTGCCTAAA GCTGATAAGA AGGCAGTTAT CCAGCATTTC
CAGGAGAAAG TGGAATCTTT GGAACAGGAA GCAGCCAACG AGAGACAGCA GCTGGTGGAG
ACACACATGG CCAGAGTGGA AGCCATGCTC AATGACCGCC GCCGCCTGGC CCTGGAGAAC
TACATCACCG CTCTGCAGGC TGTTCCTCCT CGGCCTCGTC ACGTGTTCAA TATGCTAAAG
AAGTATGTCC GCGCAGAACA GAAGGACAGA CAGCACACCC TAAAGCATTT CGAGCATGTG
CGCATGGTGG ATCCCAAGAA AGCCGCTCAG ATCCGGTCCC AGGTTATGAC ACACCTCCGT
GTGATTTATG AGCGCATGAA TCAGTCTCTC TCCCTGCTCT ACAACGTGCC TGCAGTGGCC
GAGGAGATTC AGGATGAAGT TGATGAGCTG CTTCAGAAAG AGCAAAACTA TTCAGATGAC
GTCTTGGCCA ACATGATTAG TGAACCAAGG ATCAGTTACG GAAACGATGC TCTCATGCCA
TCTTTGACCG AAACGAAAAC CACCGTGGAG CTCCTTCCCG TGAATGGAGA GTTCAGCCTG
GACGATCTCC AGCCGTGGCA TTCTTTTGGG GCTGACTCTG TGCCAGCCAA CACAGAAAAC
GAAGTTGAGC CTGTTGATGC CCGCCCTGCT GCCGACCGAG GACTGACCAC TCGACCAGGT
TCTGGGTTGA CAAATATCAA GACGGAGGAG ATCTCTGAAG TGAAGATGGA TGCAGAATTC
CGACATGACT CAGGATATGA AGTTCATCAT CAAAAATTGG TGTTCTTTGC AGAAGATGTG
GGTTCAAACA AAGGTGCAAT CATTGGACTC ATGGTGGGCG GTGTTGTCAT AGCGACAGTG
ATCGTCATCA CCTTGGTGAT GCTGAAGAAG AAACAGTACA CATCCATTCA TCATGGTGTG
GTGGAGGTTG ACGCCGCTGT CACCCCAGAG GAGCGCCACC TGTCCAAGAT GCAGCAGAAC
GGCTACGAAA ATCCAACCTA CAAGTTCTTT GAGCAGATGC AGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_958817.1
CDS201..2288
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)486..530(+)
Misc Feature(5)594..764(+)
Misc Feature(6)630..632(+)
Misc Feature(7)741..764(+)
Misc Feature(8)792..794(+)
Misc Feature(9)816..818(+)
Misc Feature(10)1068..1622(+)
Misc Feature(11)1977..1979(+)
Misc Feature(12)1989..2114(+)
Misc Feature(13)1989..1991(+)
Misc Feature(14)1989..1991(+)
Misc Feature(15)1995..1997(+)
Misc Feature(16)2043..2045(+)
Misc Feature(17)2043..2045(+)
Misc Feature(18)2046..2048(+)
Misc Feature(19)2046..2048(+)
Misc Feature(20)2088..2090(+)
Misc Feature(21)2112..2114(+)
Misc Feature(22)2115..2117(+)
Misc Feature(23)2118..2273(+)
Misc Feature(24)2130..2132(+)
Misc Feature(25)2133..2135(+)
Misc Feature(26)2190..2192(+)
Misc Feature(27)2190..2192(+)
Misc Feature(28)2202..2204(+)
Misc Feature(29)2202..2204(+)
Misc Feature(30)2202..2204(+)
Misc Feature(31)2244..2246(+)
Misc Feature(32)2259..2261(+)
Misc Feature(33)2265..2267(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1199
Gene:APP
Gene Synonym:
Exon (8)1200..1274
Gene:APP
Gene Synonym:
Exon (9)1275..1433
Gene:APP
Gene Synonym:
Exon (10)1434..1562
Gene:APP
Gene Synonym:
Exon (11)1563..1662
Gene:APP
Gene Synonym:
Exon (12)1663..1884
Gene:APP
Gene Synonym:
Exon (13)1885..1938
Gene:APP
Gene Synonym:
Exon (14)1939..2039
Gene:APP
Gene Synonym:
Exon (15)2040..2186
Gene:APP
Gene Synonym:
Exon (16)2187..3408
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_201414
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_201414

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGTTCCT ACAACAGCAG CCAGTACCCC TGATGCCGTT
GACAAGTATC TCGAGACACC TGGGGATGAG AATGAACATG CCCATTTCCA GAAAGCCAAA
GAGAGGCTTG AGGCCAAGCA CCGAGAGAGA ATGTCCCAGG TCATGAGAGA ATGGGAAGAG
GCAGAACGTC AAGCAAAGAA CTTGCCTAAA GCTGATAAGA AGGCAGTTAT CCAGCATTTC
CAGGAGAAAG TGGAATCTTT GGAACAGGAA GCAGCCAACG AGAGACAGCA GCTGGTGGAG
ACACACATGG CCAGAGTGGA AGCCATGCTC AATGACCGCC GCCGCCTGGC CCTGGAGAAC
TACATCACCG CTCTGCAGGC TGTTCCTCCT CGGCCTCGTC ACGTGTTCAA TATGCTAAAG
AAGTATGTCC GCGCAGAACA GAAGGACAGA CAGCACACCC TAAAGCATTT CGAGCATGTG
CGCATGGTGG ATCCCAAGAA AGCCGCTCAG ATCCGGTCCC AGGTTATGAC ACACCTCCGT
GTGATTTATG AGCGCATGAA TCAGTCTCTC TCCCTGCTCT ACAACGTGCC TGCAGTGGCC
GAGGAGATTC AGGATGAAGT TGATGAGCTG CTTCAGAAAG AGCAAAACTA TTCAGATGAC
GTCTTGGCCA ACATGATTAG TGAACCAAGG ATCAGTTACG GAAACGATGC TCTCATGCCA
TCTTTGACCG AAACGAAAAC CACCGTGGAG CTCCTTCCCG TGAATGGAGA GTTCAGCCTG
GACGATCTCC AGCCGTGGCA TTCTTTTGGG GCTGACTCTG TGCCAGCCAA CACAGAAAAC
GAAGTTGAGC CTGTTGATGC CCGCCCTGCT GCCGACCGAG GACTGACCAC TCGACCAGGT
TCTGGGTTGA CAAATATCAA GACGGAGGAG ATCTCTGAAG TGAAGATGGA TGCAGAATTC
CGACATGACT CAGGATATGA AGTTCATCAT CAAAAATTGG TGTTCTTTGC AGAAGATGTG
GGTTCAAACA AAGGTGCAAT CATTGGACTC ATGGTGGGCG GTGTTGTCAT AGCGACAGTG
ATCGTCATCA CCTTGGTGAT GCTGAAGAAG AAACAGTACA CATCCATTCA TCATGGTGTG
GTGGAGGTTG ACGCCGCTGT CACCCCAGAG GAGCGCCACC TGTCCAAGAT GCAGCAGAAC
GGCTACGAAA ATCCAACCTA CAAGTTCTTT GAGCAGATGC AGAACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27201
Clone ID Related Accession (Same CDS sequence) NM_001204302
Accession Version NM_001204302.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2202bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 25-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform i precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, X06989.1, Y00264.1 and BM876312.1. Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (i, also known as L-APP733) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 1429732 Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATTCCTAC AACAGCAGCC AGTACCCCTG ATGCCGTTGA CAAGTATCTC
GAGACACCTG GGGATGAGAA TGAACATGCC CATTTCCAGA AAGCCAAAGA GAGGCTTGAG
GCCAAGCACC GAGAGAGAAT GTCCCAGGTC ATGAGAGAAT GGGAAGAGGC AGAACGTCAA
GCAAAGAACT TGCCTAAAGC TGATAAGAAG GCAGTTATCC AGCATTTCCA GGAGAAAGTG
GAATCTTTGG AACAGGAAGC AGCCAACGAG AGACAGCAGC TGGTGGAGAC ACACATGGCC
AGAGTGGAAG CCATGCTCAA TGACCGCCGC CGCCTGGCCC TGGAGAACTA CATCACCGCT
CTGCAGGCTG TTCCTCCTCG GCCTCGTCAC GTGTTCAATA TGCTAAAGAA GTATGTCCGC
GCAGAACAGA AGGACAGACA GCACACCCTA AAGCATTTCG AGCATGTGCG CATGGTGGAT
CCCAAGAAAG CCGCTCAGAT CCGGTCCCAG GTTATGACAC ACCTCCGTGT GATTTATGAG
CGCATGAATC AGTCTCTCTC CCTGCTCTAC AACGTGCCTG CAGTGGCCGA GGAGATTCAG
GATGAAGTTG ATGAGCTGCT TCAGAAAGAG CAAAACTATT CAGATGACGT CTTGGCCAAC
ATGATTAGTG AACCAAGGAT CAGTTACGGA AACGATGCTC TCATGCCATC TTTGACCGAA
ACGAAAACCA CCGTGGAGCT CCTTCCCGTG AATGGAGAGT TCAGCCTGGA CGATCTCCAG
CCGTGGCATT CTTTTGGGGC TGACTCTGTG CCAGCCAACA CAGAAAACGA AGGTTCTGGG
TTGACAAATA TCAAGACGGA GGAGATCTCT GAAGTGAAGA TGGATGCAGA ATTCCGACAT
GACTCAGGAT ATGAAGTTCA TCATCAAAAA TTGGTGTTCT TTGCAGAAGA TGTGGGTTCA
AACAAAGGTG CAATCATTGG ACTCATGGTG GGCGGTGTTG TCATAGCGAC AGTGATCGTC
ATCACCTTGG TGATGCTGAA GAAGAAACAG TACACATCCA TTCATCATGG TGTGGTGGAG
GTTGACGCCG CTGTCACCCC AGAGGAGCGC CACCTGTCCA AGATGCAGCA GAACGGCTAC
GAAAATCCAA CCTACAAGTT CTTTGAGCAG ATGCAGAACT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191231.1
CDS201..2402
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)594..764(+)
Misc Feature(5)1083..1226(+)
Misc Feature(6)1095..1115(+)
Misc Feature(7)1236..1790(+)
Misc Feature(8)2103..2228(+)
Misc Feature(9)2232..2387(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1233
Gene:APP
Gene Synonym:
Exon (8)1234..1367
Gene:APP
Gene Synonym:
Exon (9)1368..1442
Gene:APP
Gene Synonym:
Exon (10)1443..1601
Gene:APP
Gene Synonym:
Exon (11)1602..1730
Gene:APP
Gene Synonym:
Exon (12)1731..1830
Gene:APP
Gene Synonym:
Exon (13)1831..2052
Gene:APP
Gene Synonym:
Exon (14)2053..2153
Gene:APP
Gene Synonym:
Exon (15)2154..2300
Gene:APP
Gene Synonym:
Exon (16)2301..3522
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001204302
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 9, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204302

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGAGGTG TGCTCTGAAC AAGCCGAGAC GGGGCCGTGC
CGAGCAATGA TCTCCCGCTG GTACTTTGAT GTGACTGAAG GGAAGTGTGC CCCATTCTTT
TACGGCGGAT GTGGCGGCAA CCGGAACAAC TTTGACACAG AAGAGTACTG CATGGCCGTG
TGTGGCAGCG CCATTCCTAC AACAGCAGCC AGTACCCCTG ATGCCGTTGA CAAGTATCTC
GAGACACCTG GGGATGAGAA TGAACATGCC CATTTCCAGA AAGCCAAAGA GAGGCTTGAG
GCCAAGCACC GAGAGAGAAT GTCCCAGGTC ATGAGAGAAT GGGAAGAGGC AGAACGTCAA
GCAAAGAACT TGCCTAAAGC TGATAAGAAG GCAGTTATCC AGCATTTCCA GGAGAAAGTG
GAATCTTTGG AACAGGAAGC AGCCAACGAG AGACAGCAGC TGGTGGAGAC ACACATGGCC
AGAGTGGAAG CCATGCTCAA TGACCGCCGC CGCCTGGCCC TGGAGAACTA CATCACCGCT
CTGCAGGCTG TTCCTCCTCG GCCTCGTCAC GTGTTCAATA TGCTAAAGAA GTATGTCCGC
GCAGAACAGA AGGACAGACA GCACACCCTA AAGCATTTCG AGCATGTGCG CATGGTGGAT
CCCAAGAAAG CCGCTCAGAT CCGGTCCCAG GTTATGACAC ACCTCCGTGT GATTTATGAG
CGCATGAATC AGTCTCTCTC CCTGCTCTAC AACGTGCCTG CAGTGGCCGA GGAGATTCAG
GATGAAGTTG ATGAGCTGCT TCAGAAAGAG CAAAACTATT CAGATGACGT CTTGGCCAAC
ATGATTAGTG AACCAAGGAT CAGTTACGGA AACGATGCTC TCATGCCATC TTTGACCGAA
ACGAAAACCA CCGTGGAGCT CCTTCCCGTG AATGGAGAGT TCAGCCTGGA CGATCTCCAG
CCGTGGCATT CTTTTGGGGC TGACTCTGTG CCAGCCAACA CAGAAAACGA AGGTTCTGGG
TTGACAAATA TCAAGACGGA GGAGATCTCT GAAGTGAAGA TGGATGCAGA ATTCCGACAT
GACTCAGGAT ATGAAGTTCA TCATCAAAAA TTGGTGTTCT TTGCAGAAGA TGTGGGTTCA
AACAAAGGTG CAATCATTGG ACTCATGGTG GGCGGTGTTG TCATAGCGAC AGTGATCGTC
ATCACCTTGG TGATGCTGAA GAAGAAACAG TACACATCCA TTCATCATGG TGTGGTGGAG
GTTGACGCCG CTGTCACCCC AGAGGAGCGC CACCTGTCCA AGATGCAGCA GAACGGCTAC
GAAAATCCAA CCTACAAGTT CTTTGAGCAG ATGCAGAACT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27287
Clone ID Related Accession (Same CDS sequence) NM_001204303
Accession Version NM_001204303.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2034bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 25-MAR-2015
Organism Homo sapiens (human)
Product amyloid beta A4 protein isoform j precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559391.1, Y00264.1 and BM876312.1. Transcript Variant: This variant (10) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (j, also known as L-APP677) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 1429732 Protein has antimicrobial activity :: PMID: 20209079 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGTTCCT ACAACAGCAG CCAGTACCCC TGATGCCGTT
GACAAGTATC TCGAGACACC TGGGGATGAG AATGAACATG CCCATTTCCA GAAAGCCAAA
GAGAGGCTTG AGGCCAAGCA CCGAGAGAGA ATGTCCCAGG TCATGAGAGA ATGGGAAGAG
GCAGAACGTC AAGCAAAGAA CTTGCCTAAA GCTGATAAGA AGGCAGTTAT CCAGCATTTC
CAGGAGAAAG TGGAATCTTT GGAACAGGAA GCAGCCAACG AGAGACAGCA GCTGGTGGAG
ACACACATGG CCAGAGTGGA AGCCATGCTC AATGACCGCC GCCGCCTGGC CCTGGAGAAC
TACATCACCG CTCTGCAGGC TGTTCCTCCT CGGCCTCGTC ACGTGTTCAA TATGCTAAAG
AAGTATGTCC GCGCAGAACA GAAGGACAGA CAGCACACCC TAAAGCATTT CGAGCATGTG
CGCATGGTGG ATCCCAAGAA AGCCGCTCAG ATCCGGTCCC AGGTTATGAC ACACCTCCGT
GTGATTTATG AGCGCATGAA TCAGTCTCTC TCCCTGCTCT ACAACGTGCC TGCAGTGGCC
GAGGAGATTC AGGATGAAGT TGATGAGCTG CTTCAGAAAG AGCAAAACTA TTCAGATGAC
GTCTTGGCCA ACATGATTAG TGAACCAAGG ATCAGTTACG GAAACGATGC TCTCATGCCA
TCTTTGACCG AAACGAAAAC CACCGTGGAG CTCCTTCCCG TGAATGGAGA GTTCAGCCTG
GACGATCTCC AGCCGTGGCA TTCTTTTGGG GCTGACTCTG TGCCAGCCAA CACAGAAAAC
GAAGGTTCTG GGTTGACAAA TATCAAGACG GAGGAGATCT CTGAAGTGAA GATGGATGCA
GAATTCCGAC ATGACTCAGG ATATGAAGTT CATCATCAAA AATTGGTGTT CTTTGCAGAA
GATGTGGGTT CAAACAAAGG TGCAATCATT GGACTCATGG TGGGCGGTGT TGTCATAGCG
ACAGTGATCG TCATCACCTT GGTGATGCTG AAGAAGAAAC AGTACACATC CATTCATCAT
GGTGTGGTGG AGGTTGACGC CGCTGTCACC CCAGAGGAGC GCCACCTGTC CAAGATGCAG
CAGAACGGCT ACGAAAATCC AACCTACAAG TTCTTTGAGC AGATGCAGAA CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191232.1
CDS201..2234
Misc Feature(1)24..26(+)
Misc Feature(2)270..764(+)
Misc Feature(3)288..593(+)
Misc Feature(4)486..530(+)
Misc Feature(5)594..764(+)
Misc Feature(6)630..632(+)
Misc Feature(7)741..764(+)
Misc Feature(8)792..794(+)
Misc Feature(9)816..818(+)
Misc Feature(10)1068..1622(+)
Misc Feature(11)1935..2060(+)
Misc Feature(12)2064..2219(+)
Exon (1)1..257
Gene:APP
Gene Synonym:
Exon (2)258..425
Gene:APP
Gene Synonym:
Exon (3)426..555
Gene:APP
Gene Synonym:
Exon (4)556..668
Gene:APP
Gene Synonym:
Exon (5)669..862
Gene:APP
Gene Synonym:
Exon (6)863..1065
Gene:APP
Gene Synonym:
Exon (7)1066..1199
Gene:APP
Gene Synonym:
Exon (8)1200..1274
Gene:APP
Gene Synonym:
Exon (9)1275..1433
Gene:APP
Gene Synonym:
Exon (10)1434..1562
Gene:APP
Gene Synonym:
Exon (11)1563..1662
Gene:APP
Gene Synonym:
Exon (12)1663..1884
Gene:APP
Gene Synonym:
Exon (13)1885..1985
Gene:APP
Gene Synonym:
Exon (14)1986..2132
Gene:APP
Gene Synonym:
Exon (15)2133..3354
Gene:APP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001204303
Organism Homo sapiens (human)
Definition Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 10, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204303

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGCTGCCCG GTTTGGCACT GCTCCTGCTG GCCGCCTGGA CGGCTCGGGC GCTGGAGGTA 
CCCACTGATG GTAATGCTGG CCTGCTGGCT GAACCCCAGA TTGCCATGTT CTGTGGCAGA
CTGAACATGC ACATGAATGT CCAGAATGGG AAGTGGGATT CAGATCCATC AGGGACCAAA
ACCTGCATTG ATACCAAGGA AGGCATCCTG CAGTATTGCC AAGAAGTCTA CCCTGAACTG
CAGATCACCA ATGTGGTAGA AGCCAACCAA CCAGTGACCA TCCAGAACTG GTGCAAGCGG
GGCCGCAAGC AGTGCAAGAC CCATCCCCAC TTTGTGATTC CCTACCGCTG CTTAGTTGGT
GAGTTTGTAA GTGATGCCCT TCTCGTTCCT GACAAGTGCA AATTCTTACA CCAGGAGAGG
ATGGATGTTT GCGAAACTCA TCTTCACTGG CACACCGTCG CCAAAGAGAC ATGCAGTGAG
AAGAGTACCA ACTTGCATGA CTACGGCATG TTGCTGCCCT GCGGAATTGA CAAGTTCCGA
GGGGTAGAGT TTGTGTGTTG CCCACTGGCT GAAGAAAGTG ACAATGTGGA TTCTGCTGAT
GCGGAGGAGG ATGACTCGGA TGTCTGGTGG GGCGGAGCAG ACACAGACTA TGCAGATGGG
AGTGAAGACA AAGTAGTAGA AGTAGCAGAG GAGGAAGAAG TGGCTGAGGT GGAAGAAGAA
GAAGCCGATG ATGACGAGGA CGATGAGGAT GGTGATGAGG TAGAGGAAGA GGCTGAGGAA
CCCTACGAAG AAGCCACAGA GAGAACCACC AGCATTGCCA CCACCACCAC CACCACCACA
GAGTCTGTGG AAGAGGTGGT TCGAGTTCCT ACAACAGCAG CCAGTACCCC TGATGCCGTT
GACAAGTATC TCGAGACACC TGGGGATGAG AATGAACATG CCCATTTCCA GAAAGCCAAA
GAGAGGCTTG AGGCCAAGCA CCGAGAGAGA ATGTCCCAGG TCATGAGAGA ATGGGAAGAG
GCAGAACGTC AAGCAAAGAA CTTGCCTAAA GCTGATAAGA AGGCAGTTAT CCAGCATTTC
CAGGAGAAAG TGGAATCTTT GGAACAGGAA GCAGCCAACG AGAGACAGCA GCTGGTGGAG
ACACACATGG CCAGAGTGGA AGCCATGCTC AATGACCGCC GCCGCCTGGC CCTGGAGAAC
TACATCACCG CTCTGCAGGC TGTTCCTCCT CGGCCTCGTC ACGTGTTCAA TATGCTAAAG
AAGTATGTCC GCGCAGAACA GAAGGACAGA CAGCACACCC TAAAGCATTT CGAGCATGTG
CGCATGGTGG ATCCCAAGAA AGCCGCTCAG ATCCGGTCCC AGGTTATGAC ACACCTCCGT
GTGATTTATG AGCGCATGAA TCAGTCTCTC TCCCTGCTCT ACAACGTGCC TGCAGTGGCC
GAGGAGATTC AGGATGAAGT TGATGAGCTG CTTCAGAAAG AGCAAAACTA TTCAGATGAC
GTCTTGGCCA ACATGATTAG TGAACCAAGG ATCAGTTACG GAAACGATGC TCTCATGCCA
TCTTTGACCG AAACGAAAAC CACCGTGGAG CTCCTTCCCG TGAATGGAGA GTTCAGCCTG
GACGATCTCC AGCCGTGGCA TTCTTTTGGG GCTGACTCTG TGCCAGCCAA CACAGAAAAC
GAAGGTTCTG GGTTGACAAA TATCAAGACG GAGGAGATCT CTGAAGTGAA GATGGATGCA
GAATTCCGAC ATGACTCAGG ATATGAAGTT CATCATCAAA AATTGGTGTT CTTTGCAGAA
GATGTGGGTT CAAACAAAGG TGCAATCATT GGACTCATGG TGGGCGGTGT TGTCATAGCG
ACAGTGATCG TCATCACCTT GGTGATGCTG AAGAAGAAAC AGTACACATC CATTCATCAT
GGTGTGGTGG AGGTTGACGC CGCTGTCACC CCAGAGGAGC GCCACCTGTC CAAGATGCAG
CAGAACGGCT ACGAAAATCC AACCTACAAG TTCTTTGAGC AGATGCAGAA CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Interaction of Alzheimer's beta-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation
Biochemistry 53 (28), 4489-4502 (2014)
Di Scala C, Chahinian H, Yahi N, Garmy N and Fantini J.


book

Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers
JAMA Neurol 71 (7), 855-862 (2014)
Kester MI, Goos JD, Teunissen CE, Benedictus MR, Bouwman FH, Wattjes MP, Barkhof F, Scheltens P and van der Flier WM.


book

Gene-environment interactions: lifetime cognitive activity, APOE genotype, and beta-amyloid burden
J. Neurosci. 34 (25), 8612-8617 (2014)
Wirth M, Villeneuve S, La Joie R, Marks SM and Jagust WJ.


book

Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain
BMC Neurosci 15, 74 (2014)
Spears W, Furgerson M, Sweetnam JM, Evans P, Gearing M, Fechheimer M and Furukawa R.


book

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide
PLoS ONE 5 (3), E9505 (2010)
Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE and Moir RD.


book

Early-Onset Familial Alzheimer Disease
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bird,T.D.


book

Alzheimer Disease Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bird,T.D.


book

Schizophrenia scepticism
Nat. Genet. 2 (1), 12 (1992)
Mant,R., Asherson,P., Gill,M., McGuffin,P., Owen,M., Wert,S.E., Gregory,R.J., Smith,A.E., Cohn,J.A., Wilson,J.M. et al.


book

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
Nat. Genet. 1 (5), 345-347 (1992)
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B and Lannfelt L.


book

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
Nat. Genet. 1 (3), 218-221 (1992)
Hendriks L, van Duijn CM, Cras P, Cruts M, Van Hul W, van Harskamp F, Warren A, McInnis MG, Antonarakis SE and Martin JJ.


 
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