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IL1B interleukin 1, beta [Homo sapiens (human)]

Gene Symbol IL1B
Entrez Gene ID 3553
Full Name interleukin 1, beta
Synonyms IL-1, IL1-BETA, IL1F2
General protein information
Preferred Names
interleukin-1 beta
Names
interleukin-1 beta
IL-1 beta
catabolin
preinterleukin 1 beta
pro-interleukin-1-beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14

Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

147720

Disorder Html: {Gastric cancer risk after H. pylori infection}, 137215 (3)





The following IL1B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu36205 XM_006712496 PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu25334 NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.3
$309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu36205
Accession Version XM_006712496.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_006712559.1
CDS507..1082
Misc Feature(1)639..1067(+)
Misc Feature(2)645..1055(+)
Misc Feature(3)660..1010(+)
Translation
Position Chain Variation Link
3 3 a, g dbSNP:556698777
17 17 c, g, t dbSNP:533327440
25 25 a, g dbSNP:755035830
28 28 a, c dbSNP:370988408
36 36 c, t dbSNP:766271872
37 37 a, g dbSNP:762704392
43 43 a, g dbSNP:376289593
47 47 c, t dbSNP:369312177
50 50 c, t dbSNP:764829099
57 57 c, t dbSNP:761463780
63 63 c, t dbSNP:137872663
65 65 a, g dbSNP:763810887
92 92 c, g dbSNP:760315164
107 107 a, t dbSNP:200223008
113 113 a, c dbSNP:766796135
115 115 c, t dbSNP:569468521
118 118 g, t dbSNP:755758115
121 121 g, t dbSNP:373677368
132 132 a, g dbSNP:767111055
135 135 a, c dbSNP:373127037
139 139 a, t dbSNP:369824057
152 152 a, g dbSNP:758962139
153 153 c, t dbSNP:140794289
154 154 a, g dbSNP:140821206
156 156 a, c, t dbSNP:143589371
160 160 a, c dbSNP:529396429
165 165 a, g dbSNP:760831358
167 167 a, g dbSNP:775562734
174 174 c, t dbSNP:538083388
175 175 a, g dbSNP:568715066
186 186 c, t dbSNP:16062
198 198 c, t dbSNP:770945985
201 201 a, g dbSNP:749096227
203 203 a, g dbSNP:200278471
208 208 a, g dbSNP:755957216
209 209 c, t dbSNP:371093341
210 210 a, g dbSNP:780676196
237 237 a, g dbSNP:754564004
243 243 a, g dbSNP:750985322
249 249 a, g dbSNP:62157449
269 269 g, t dbSNP:376341819
279 279 c, t dbSNP:373172825
280 280 a, g dbSNP:371339015
282 282 c, t dbSNP:531916859
290 290 c, t dbSNP:200401035
294 294 c, t dbSNP:772164980
302 302 -, t dbSNP:774777265
306 306 a, c dbSNP:759687974
320 320 c, g dbSNP:376739961
326 326 c, t dbSNP:771002814
327 327 a, c dbSNP:749292149
331 331 a, g dbSNP:777845999
332 332 c, t dbSNP:373431213
347 347 c, t dbSNP:190212930
351 351 g, t dbSNP:780918036
355 355 c, t dbSNP:201641509
369 369 a, g dbSNP:551595771
384 384 a, g dbSNP:762344697
418 418 c, t dbSNP:531892312
430 430 c, g dbSNP:563094943
437 437 a, t dbSNP:543306451
466 466 a, c dbSNP:529645738
480 480 a, t dbSNP:373108742
504 504 a, t dbSNP:559871123
533 533 a, c dbSNP:774838456
549 549 a, c dbSNP:769400829
565 565 c, t dbSNP:745499901
575 575 a, g dbSNP:752959492
578 578 g, t dbSNP:767816421
586 586 c, t dbSNP:373103547
587 587 c, t dbSNP:1143634
588 588 a, g dbSNP:139843362
590 590 c, t dbSNP:766629497
593 593 a, g dbSNP:148588074
597 597 a, g dbSNP:773330409
599 599 c, t dbSNP:769804231
602 602 a, c, t dbSNP:141525769
603 603 a, g dbSNP:201772036
606 606 a, g dbSNP:372265184
608 608 a, t dbSNP:779679002
613 613 c, t dbSNP:571556428
614 614 g, t dbSNP:745362909
615 615 c, t dbSNP:778278424
617 617 c, t dbSNP:756541790
620 620 c, t dbSNP:753113614
633 633 c, t dbSNP:767825199
636 636 c, g dbSNP:755362270
640 640 a, g dbSNP:751767196
646 646 c, t dbSNP:766684369
647 647 a, g dbSNP:551821803
651 651 c, t dbSNP:200498551
652 652 a, g dbSNP:765269921
672 672 c, t dbSNP:200789364
673 673 a, t dbSNP:761597173
675 675 a, g dbSNP:776618633
695 695 a, c dbSNP:144640380
704 704 g, t dbSNP:746790289
711 711 c, t dbSNP:775174784
714 714 a, c dbSNP:771667570
722 722 a, g dbSNP:745418043
727 727 c, t dbSNP:778331869
730 730 a, g dbSNP:756774985
740 740 g, t dbSNP:771720874
757 757 c, t dbSNP:375479974
759 759 g, t dbSNP:78226748
764 764 a, c dbSNP:773984279
774 774 a, g dbSNP:770384688
806 806 c, t dbSNP:267598837
809 809 g, t dbSNP:774783730
812 812 a, c, g dbSNP:747380647
827 827 c, g dbSNP:192715508
830 830 c, g dbSNP:758822761
834 834 a, c, g, t dbSNP:144433180
848 848 c, t dbSNP:753907701
855 855 a, g dbSNP:763972631
862 862 a, g dbSNP:760543225
876 876 a, g dbSNP:751326922
902 902 a, g dbSNP:138009692
913 913 a, g, t dbSNP:772717932
923 923 c, t dbSNP:764879783
926 926 a, c dbSNP:761403727
931 931 c, t dbSNP:776195456
942 942 a, g dbSNP:772647095
963 963 g, t dbSNP:746237682
965 965 a, c, t dbSNP:140343610
968 968 a, g dbSNP:771077544
977 977 c, t dbSNP:749569629
984 984 a, g dbSNP:553523253
987 987 a, g, t dbSNP:146219183
989 989 c, t dbSNP:200794209
1014 1014 a, g dbSNP:781114719
1030 1030 c, t dbSNP:754871430
1037 1037 a, c, t dbSNP:368729538
1038 1038 a, g dbSNP:758098043
1039 1039 g, t dbSNP:539539347
1052 1052 c, t dbSNP:750156794
1053 1053 a, g dbSNP:764969583
1055 1055 c, t dbSNP:761420279
1079 1079 c, t dbSNP:776211846
1081 1081 a, g dbSNP:147880290
1092 1092 c, t dbSNP:760036789
1096 1096 c, t dbSNP:774695305
1100 1100 a, g dbSNP:771362330
1105 1105 c, g dbSNP:367691903
1107 1107 a, g dbSNP:749606925
1112 1112 a, g dbSNP:773501040
1115 1115 g, t dbSNP:769939971
1143 1143 a, g dbSNP:188964071
1168 1168 c, t dbSNP:570717396
1183 1183 a, c dbSNP:10176689
1204 1204 a, t dbSNP:763169464
1279 1279 c, t dbSNP:771537638
1366 1366 c, t dbSNP:537366413
1373 1373 c, t dbSNP:567700928
1377 1377 a, g dbSNP:547808878
1419 1419 -, c dbSNP:755240753
1421 1421 c, t dbSNP:528183322
1498 1498 g, t dbSNP:15610
1542 1542 -, caatt dbSNP:144284916
1556 1556 a, g dbSNP:565675977
1561 1561 c, g dbSNP:142194680
1587 1587 c, g dbSNP:1071676
1597 1597 a, t dbSNP:768605724
1613 1613 c, t dbSNP:533906112
1627 1627 c, t dbSNP:749231749

Target ORF information:

RefSeq Version XM_006712496
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006712496

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25334
Accession Version NM_000576.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta proprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M15330.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2003 this sequence version replaced gi:10835144. Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008678.1, K02770.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000567.1
CDS88..897
Misc Feature(1)88..396(+)
Misc Feature(2)166..168(+)
Misc Feature(3)166..168(+)
Misc Feature(4)433..435(+)
Misc Feature(5)433..435(+)
Misc Feature(6)445..447(+)
Misc Feature(7)454..882(+)
Misc Feature(8)460..870(+)
Misc Feature(9)475..825(+)
Misc Feature(10)508..510(+)
Exon (1)1..72
Gene:IL1B
Gene Synonym:
Exon (2)73..134
Gene:IL1B
Gene Synonym:
Exon (3)135..186
Gene:IL1B
Gene Synonym:
Exon (4)187..388
Gene:IL1B
Gene Synonym:
Exon (5)389..553
Gene:IL1B
Gene Synonym:
Exon (6)554..684
Gene:IL1B
Gene Synonym:
Exon (7)685..1498
Gene:IL1B
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, c dbSNP:561088583
20 20 a, c dbSNP:1133555
26 26 a, t dbSNP:115403599
39 39 c, g dbSNP:781566483
40 40 g, t dbSNP:1799916
49 49 c, t dbSNP:1133558
75 75 a, g dbSNP:556698777
89 89 c, g, t dbSNP:533327440
97 97 a, g dbSNP:755035830
100 100 a, c dbSNP:370988408
108 108 c, t dbSNP:766271872
109 109 a, g dbSNP:762704392
115 115 a, g dbSNP:376289593
119 119 c, t dbSNP:369312177
122 122 c, t dbSNP:764829099
129 129 c, t dbSNP:761463780
135 135 c, t dbSNP:137872663
137 137 a, g dbSNP:763810887
164 164 c, g dbSNP:760315164
179 179 a, t dbSNP:200223008
185 185 a, c dbSNP:766796135
187 187 c, t dbSNP:569468521
190 190 g, t dbSNP:755758115
193 193 g, t dbSNP:373677368
204 204 a, g dbSNP:767111055
207 207 a, c dbSNP:373127037
211 211 a, t dbSNP:369824057
224 224 a, g dbSNP:758962139
225 225 c, t dbSNP:140794289
226 226 a, g dbSNP:140821206
228 228 a, c, t dbSNP:143589371
232 232 a, c dbSNP:529396429
237 237 a, g dbSNP:760831358
239 239 a, g dbSNP:775562734
246 246 c, t dbSNP:538083388
247 247 a, g dbSNP:568715066
258 258 c, t dbSNP:16062
270 270 c, t dbSNP:770945985
273 273 a, g dbSNP:749096227
275 275 a, g dbSNP:200278471
280 280 a, g dbSNP:755957216
281 281 c, t dbSNP:371093341
282 282 a, g dbSNP:780676196
309 309 a, g dbSNP:754564004
315 315 a, g dbSNP:750985322
321 321 a, g dbSNP:62157449
341 341 g, t dbSNP:376341819
351 351 c, t dbSNP:373172825
352 352 a, g dbSNP:371339015
354 354 c, t dbSNP:531916859
362 362 c, t dbSNP:200401035
366 366 c, t dbSNP:772164980
374 374 -, t dbSNP:774777265
378 378 a, c dbSNP:759687974
390 390 a, g dbSNP:752959492
393 393 g, t dbSNP:767816421
401 401 c, t dbSNP:373103547
402 402 c, t dbSNP:1143634
403 403 a, g dbSNP:139843362
405 405 c, t dbSNP:766629497
408 408 a, g dbSNP:148588074
412 412 a, g dbSNP:773330409
414 414 c, t dbSNP:769804231
417 417 a, c, t dbSNP:141525769
418 418 a, g dbSNP:201772036
421 421 a, g dbSNP:372265184
423 423 a, t dbSNP:779679002
428 428 c, t dbSNP:571556428
429 429 g, t dbSNP:745362909
430 430 c, t dbSNP:778278424
432 432 c, t dbSNP:756541790
435 435 c, t dbSNP:753113614
448 448 c, t dbSNP:767825199
451 451 c, g dbSNP:755362270
455 455 a, g dbSNP:751767196
461 461 c, t dbSNP:766684369
462 462 a, g dbSNP:551821803
466 466 c, t dbSNP:200498551
467 467 a, g dbSNP:765269921
487 487 c, t dbSNP:200789364
488 488 a, t dbSNP:761597173
490 490 a, g dbSNP:776618633
510 510 a, c dbSNP:144640380
519 519 g, t dbSNP:746790289
526 526 c, t dbSNP:775174784
529 529 a, c dbSNP:771667570
537 537 a, g dbSNP:745418043
542 542 c, t dbSNP:778331869
545 545 a, g dbSNP:756774985
555 555 g, t dbSNP:771720874
572 572 c, t dbSNP:375479974
574 574 g, t dbSNP:78226748
579 579 a, c dbSNP:773984279
589 589 a, g dbSNP:770384688
621 621 c, t dbSNP:267598837
624 624 g, t dbSNP:774783730
627 627 a, c, g dbSNP:747380647
642 642 c, g dbSNP:192715508
645 645 c, g dbSNP:758822761
649 649 a, c, g, t dbSNP:144433180
663 663 c, t dbSNP:753907701
670 670 a, g dbSNP:763972631
677 677 a, g dbSNP:760543225
691 691 a, g dbSNP:751326922
717 717 a, g dbSNP:138009692
728 728 a, g, t dbSNP:772717932
738 738 c, t dbSNP:764879783
741 741 a, c dbSNP:761403727
746 746 c, t dbSNP:776195456
757 757 a, g dbSNP:772647095
778 778 g, t dbSNP:746237682
780 780 a, c, t dbSNP:140343610
783 783 a, g dbSNP:771077544
792 792 c, t dbSNP:749569629
799 799 a, g dbSNP:553523253
802 802 a, g, t dbSNP:146219183
804 804 c, t dbSNP:200794209
829 829 a, g dbSNP:781114719
845 845 c, t dbSNP:754871430
852 852 a, c, t dbSNP:368729538
853 853 a, g dbSNP:758098043
854 854 g, t dbSNP:539539347
867 867 c, t dbSNP:750156794
868 868 a, g dbSNP:764969583
870 870 c, t dbSNP:761420279
894 894 c, t dbSNP:776211846
896 896 a, g dbSNP:147880290
907 907 c, t dbSNP:760036789
911 911 c, t dbSNP:774695305
915 915 a, g dbSNP:771362330
920 920 c, g dbSNP:367691903
922 922 a, g dbSNP:749606925
927 927 a, g dbSNP:773501040
930 930 g, t dbSNP:769939971
958 958 a, g dbSNP:188964071
983 983 c, t dbSNP:570717396
998 998 a, c dbSNP:10176689
1019 1019 a, t dbSNP:763169464
1094 1094 c, t dbSNP:771537638
1181 1181 c, t dbSNP:537366413
1188 1188 c, t dbSNP:567700928
1192 1192 a, g dbSNP:547808878
1234 1234 -, c dbSNP:755240753
1236 1236 c, t dbSNP:528183322
1313 1313 g, t dbSNP:15610
1357 1357 -, caatt dbSNP:144284916
1371 1371 a, g dbSNP:565675977
1376 1376 c, g dbSNP:142194680
1402 1402 c, g dbSNP:1071676
1412 1412 a, t dbSNP:768605724
1428 1428 c, t dbSNP:533906112
1442 1442 c, t dbSNP:749231749

Target ORF information:

RefSeq Version NM_000576
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 1, beta (IL1B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000576

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.