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IL1B cDNA ORF clone, Homo sapiens (human)

Gene Symbol IL1B
Entrez Gene ID 3553
Full Name interleukin 1, beta
Synonyms IL-1, IL1-BETA, IL1F2
General protein information
Preferred Names
interleukin-1 beta
Names
interleukin-1 beta
IL-1 beta
catabolin
preinterleukin 1 beta
pro-interleukin-1-beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14

Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

147720

Disorder Html: {Gastric cancer risk after H. pylori infection}, 137215 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006712496 XP_006712559 interleukin-1 beta isoform X1
NM_000576 NP_000567 interleukin-1 beta proprotein



Homo sapiens (human) IL1B NP_000567.1
Pan troglodytes (chimpanzee) IL1B XP_001147075.1
Macaca mulatta (Rhesus monkey) IL1B NP_001036221.1
Canis lupus familiaris (dog) IL1B NP_001033060.1
Bos taurus (cattle) IL1B NP_776518.1
Mus musculus (house mouse) Il1b NP_032387.1
Rattus norvegicus (Norway rat) Il1b NP_113700.2
Xenopus (Silurana) tropicalis (western clawed frog) il1b XP_002932618.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu36205 XM_006712496 PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu25334
NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu36205
Clone ID Related Accession (Same CDS sequence) XM_006712496
Accession Version XM_006712496.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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181
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481
541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006712559.1
CDS507..1082
Misc Feature(1)639..1067(+)
Misc Feature(2)645..1055(+)
Misc Feature(3)660..1010(+)
Translation

Target ORF information:

RefSeq Version XM_006712496
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006712496

ORF Insert Sequence:

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61
121
181
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541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25334
Clone ID Related Accession (Same CDS sequence) NM_000576
Accession Version NM_000576.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta proprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M15330.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2003 this sequence version replaced gi:10835144. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008678.1, K02770.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

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ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000567.1
CDS88..897
Misc Feature(1)88..396(+)
Misc Feature(2)166..168(+)
Misc Feature(3)166..168(+)
Misc Feature(4)433..435(+)
Misc Feature(5)433..435(+)
Misc Feature(6)445..447(+)
Misc Feature(7)454..882(+)
Misc Feature(8)460..870(+)
Misc Feature(9)475..825(+)
Misc Feature(10)508..510(+)
Exon (1)1..72
Gene:IL1B
Gene Synonym:
Exon (2)73..134
Gene:IL1B
Gene Synonym:
Exon (3)135..186
Gene:IL1B
Gene Synonym:
Exon (4)187..388
Gene:IL1B
Gene Synonym:
Exon (5)389..553
Gene:IL1B
Gene Synonym:
Exon (6)554..684
Gene:IL1B
Gene Synonym:
Exon (7)685..1498
Gene:IL1B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000576
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 1, beta (IL1B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000576

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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