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IL1B cDNA ORF clone, Homo sapiens (human)

Gene Symbol IL1B
Entrez Gene ID 3553
Full Name interleukin 1, beta
Synonyms IL-1, IL1-BETA, IL1F2
General protein information
Preferred Names
interleukin-1 beta
Names
interleukin-1 beta
IL-1 beta
catabolin
preinterleukin 1 beta
pro-interleukin-1-beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14

Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

147720

Disorder Html: {Gastric cancer risk after H. pylori infection}, 137215 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006712496 XP_006712559 interleukin-1 beta isoform X1
NM_000576 NP_000567 interleukin-1 beta proprotein

KEGG
hsa04060 Cytokine-cytokine receptor interaction
hsa04210 Apoptosis
hsa04010 MAPK signaling pathway
hsa04640 Hematopoietic cell lineage
hsa04940 Type I diabetes mellitus
hsa04620 Toll-like receptor signaling pathway
hsa05010 Alzheimer's disease
hsa05332 Graft-versus-host disease
hsa05020 Prion diseases
hsa04621 NOD-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa05142 Chagas disease (American trypanosomiasis)
hsa05140 Leishmaniasis
hsa05146 Amoebiasis
hsa05144 Malaria
hsa04380 Osteoclast differentiation
hsa05323 Rheumatoid arthritis
hsa05143 African trypanosomiasis
hsa05162 Measles
hsa05152 Tuberculosis
hsa05133 Pertussis
hsa05164 Influenza A
hsa05132 Salmonella infection
hsa05168 Herpes simplex infection
hsa05134 Legionellosis
hsa04064 NF-kappa B signaling pathway
hsa04750 Inflammatory mediator regulation of TRP channels
hsa05321 Inflammatory bowel disease (IBD)
hsa04668 TNF signaling pathway
hsa04932 Non-alcoholic fatty liver disease (NAFLD)
Reactome
R-HSA-168256 Immune System
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-448706 Interleukin-1 processing
R-HSA-446652 Interleukin-1 signaling
R-HSA-449147 Signaling by Interleukins
Pathway Interaction Database
il27pathway IL27-mediated signaling events
il1pathway IL1-mediated signaling events
il12_2pathway IL12-mediated signaling events
ifngpathway IFN-gamma pathway
il23pathway IL23-mediated signaling events
anthraxpathway Cellular roles of Anthrax toxin
WikiPathways
WP382 MAPK signaling pathway
WP289 Myometrial Relaxation and Contraction Pathways
WP1433 NOD pathway
WP530 Cytokines and Inflammatory Response
WP615 Senescence and Autophagy
WP15 Selenium Pathway
WP727 Monoamine Transport
WP75 Toll-like receptor signaling pathway
WP69 TCR Signaling Pathway
WP706 SIDS Susceptibility Pathways
WP195 IL-1 Signaling Pathway
WP619 Type II interferon signaling (IFNG)
WP2059 Alzheimers Disease
WP2431 Spinal Cord Injury
WP1449 Regulation of toll-like receptor signaling pathway
WP1455 Serotonin Transporter Activity


Homo sapiens (human) IL1B NP_000567.1
Pan troglodytes (chimpanzee) IL1B XP_001147075.1
Macaca mulatta (Rhesus monkey) IL1B NP_001036221.1
Canis lupus familiaris (dog) IL1B NP_001033060.1
Bos taurus (cattle) IL1B NP_776518.1
Mus musculus (house mouse) Il1b NP_032387.1
Rattus norvegicus (Norway rat) Il1b NP_113700.2
Xenopus (Silurana) tropicalis (western clawed frog) il1b XP_002932618.1

Component

ID Name Evidence
GO:0005576 extracellular region EXP
GO:0005576 extracellular region NAS
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IMP
GO:0005829 cytosol TAS
GO:0030141 stored secretory granule IEA
GO:0031982 vesicle IEA

Function

ID Name Evidence
GO:0005125 cytokine activity IDA
GO:0005125 cytokine activity IMP
GO:0005149 interleukin-1 receptor binding NAS
GO:0005515 protein binding IPI
GO:0008083 growth factor activity IEA
GO:0019904 protein domain specific binding IPI

Process

ID Name Evidence
GO:0000187 activation of MAPK activity IDA
GO:0001666 response to hypoxia IEA
GO:0001934 positive regulation of protein phosphorylation IDA
GO:0001934 positive regulation of protein phosphorylation NAS
GO:0002439 chronic inflammatory response to antigenic stimulus IEA
GO:0002711 positive regulation of T cell mediated immunity IC
GO:0006915 apoptosis TAS
GO:0006916 anti-apoptosis IDA
GO:0006954 inflammatory response IDA
GO:0006954 inflammatory response NAS
GO:0006955 immune response IEA
GO:0007165 signal transduction TAS
GO:0007204 elevation of cytosolic calcium ion concentration IEA
GO:0007267 cell-cell signaling TAS
GO:0007566 embryo implantation TAS
GO:0007568 aging IEA
GO:0007584 response to nutrient IEA
GO:0007613 memory IEA
GO:0008285 negative regulation of cell proliferation IDA
GO:0009408 response to heat IEA
GO:0010193 response to ozone IEA
GO:0010243 response to organic nitrogen IEA
GO:0010332 response to gamma radiation IEA
GO:0010575 positive regulation vascular endothelial growth factor production ISS
GO:0010829 negative regulation of glucose transport ISS
GO:0014050 negative regulation of glutamate secretion IEA
GO:0014070 response to organic cyclic compound IEA
GO:0014805 smooth muscle adaptation NAS
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0030593 neutrophil chemotaxis IEA
GO:0030728 ovulation IEA
GO:0030730 sequestering of triglyceride IDA
GO:0031622 positive regulation of fever generation ISS
GO:0032308 positive regulation of prostaglandin secretion ISS
GO:0032355 response to estradiol stimulus IEA
GO:0032496 response to lipopolysaccharide IEA
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
GO:0032729 positive regulation of interferon-gamma production IDA
GO:0032755 positive regulation of interleukin-6 production TAS
GO:0032757 positive regulation of interleukin-8 production IDA
GO:0032874 positive regulation of stress-activated MAPK cascade IEA
GO:0033129 positive regulation of histone phosphorylation NAS
GO:0033198 response to ATP IEA
GO:0033280 response to vitamin D IEA
GO:0033591 response to L-ascorbic acid IEA
GO:0034116 positive regulation of heterotypic cell-cell adhesion NAS
GO:0035066 positive regulation of histone acetylation NAS
GO:0035176 social behavior IEA
GO:0035505 positive regulation of myosin light chain kinase activity IDA
GO:0035690 cellular response to drug IDA
GO:0042060 wound healing IEA
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042346 positive regulation of NF-kappaB import into nucleus IDA
GO:0043065 positive regulation of apoptosis IEA
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade IDA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEA
GO:0043278 response to morphine IEA
GO:0043407 negative regulation of MAP kinase activity ISS
GO:0043507 positive regulation of JUN kinase activity IEA
GO:0045080 positive regulation of chemokine biosynthetic process IEA
GO:0045086 positive regulation of interleukin-2 biosynthetic process IMP
GO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
GO:0045429 positive regulation of nitric oxide biosynthetic process IDA
GO:0045766 positive regulation of angiogenesis ISS
GO:0045833 negative regulation of lipid metabolic process ISS
GO:0045840 positive regulation of mitosis IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:0046330 positive regulation of JNK cascade IEA
GO:0046627 negative regulation of insulin receptor signaling pathway ISS
GO:0046827 positive regulation of protein export from nucleus NAS
GO:0050796 regulation of insulin secretion IDA
GO:0050900 leukocyte migration IEA
GO:0050995 negative regulation of lipid catabolic process IDA
GO:0050996 positive regulation of lipid catabolic process ISS
GO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
GO:0051384 response to glucocorticoid stimulus IEA
GO:0051781 positive regulation of cell division IEA
GO:0060355 positive regulation of cell adhesion molecule production NAS
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity IDA
GO:0070164 negative regulation of adiponectin secretion ISS
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
GO:0071260 cellular response to mechanical stimulus IEP
GO:0071310 cellular response to organic substance IDA
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IDA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu36205 XM_006712496 PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu25334
NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $154.50
$309.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu36205
Accession Version XM_006712496.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_006712559.1
CDS507..1082
Misc Feature(1)639..1067(+)
Misc Feature(2)645..1055(+)
Misc Feature(3)660..1010(+)
Translation
Position Chain Variation Link
3 3 a, g dbSNP:556698777
17 17 c, g, t dbSNP:533327440
25 25 a, g dbSNP:755035830
28 28 a, c dbSNP:370988408
36 36 c, t dbSNP:766271872
37 37 a, g dbSNP:762704392
43 43 a, g dbSNP:376289593
47 47 c, t dbSNP:369312177
50 50 c, t dbSNP:764829099
57 57 c, t dbSNP:761463780
63 63 c, t dbSNP:137872663
65 65 a, g dbSNP:763810887
92 92 c, g dbSNP:760315164
107 107 a, t dbSNP:200223008
113 113 a, c dbSNP:766796135
115 115 c, t dbSNP:569468521
118 118 g, t dbSNP:755758115
121 121 g, t dbSNP:373677368
132 132 a, g dbSNP:767111055
135 135 a, c dbSNP:373127037
139 139 a, t dbSNP:369824057
152 152 a, g dbSNP:758962139
153 153 c, t dbSNP:140794289
154 154 a, g dbSNP:140821206
156 156 a, c, t dbSNP:143589371
160 160 a, c dbSNP:529396429
165 165 a, g dbSNP:760831358
167 167 a, g dbSNP:775562734
174 174 c, t dbSNP:538083388
175 175 a, g dbSNP:568715066
186 186 c, t dbSNP:16062
198 198 c, t dbSNP:770945985
201 201 a, g dbSNP:749096227
203 203 a, g dbSNP:200278471
208 208 a, g dbSNP:755957216
209 209 c, t dbSNP:371093341
210 210 a, g dbSNP:780676196
237 237 a, g dbSNP:754564004
243 243 a, g dbSNP:750985322
249 249 a, g dbSNP:62157449
269 269 g, t dbSNP:376341819
279 279 c, t dbSNP:373172825
280 280 a, g dbSNP:371339015
282 282 c, t dbSNP:531916859
290 290 c, t dbSNP:200401035
294 294 c, t dbSNP:772164980
302 302 -, t dbSNP:774777265
306 306 a, c dbSNP:759687974
320 320 c, g dbSNP:376739961
326 326 c, t dbSNP:771002814
327 327 a, c dbSNP:749292149
331 331 a, g dbSNP:777845999
332 332 c, t dbSNP:373431213
347 347 c, t dbSNP:190212930
351 351 g, t dbSNP:780918036
355 355 c, t dbSNP:201641509
369 369 a, g dbSNP:551595771
384 384 a, g dbSNP:762344697
418 418 c, t dbSNP:531892312
430 430 c, g dbSNP:563094943
437 437 a, t dbSNP:543306451
466 466 a, c dbSNP:529645738
480 480 a, t dbSNP:373108742
504 504 a, t dbSNP:559871123
533 533 a, c dbSNP:774838456
549 549 a, c dbSNP:769400829
565 565 c, t dbSNP:745499901
575 575 a, g dbSNP:752959492
578 578 g, t dbSNP:767816421
586 586 c, t dbSNP:373103547
587 587 c, t dbSNP:1143634
588 588 a, g dbSNP:139843362
590 590 c, t dbSNP:766629497
593 593 a, g dbSNP:148588074
597 597 a, g dbSNP:773330409
599 599 c, t dbSNP:769804231
602 602 a, c, t dbSNP:141525769
603 603 a, g dbSNP:201772036
606 606 a, g dbSNP:372265184
608 608 a, t dbSNP:779679002
613 613 c, t dbSNP:571556428
614 614 g, t dbSNP:745362909
615 615 c, t dbSNP:778278424
617 617 c, t dbSNP:756541790
620 620 c, t dbSNP:753113614
633 633 c, t dbSNP:767825199
636 636 c, g dbSNP:755362270
640 640 a, g dbSNP:751767196
646 646 c, t dbSNP:766684369
647 647 a, g dbSNP:551821803
651 651 c, t dbSNP:200498551
652 652 a, g dbSNP:765269921
672 672 c, t dbSNP:200789364
673 673 a, t dbSNP:761597173
675 675 a, g dbSNP:776618633
695 695 a, c dbSNP:144640380
704 704 g, t dbSNP:746790289
711 711 c, t dbSNP:775174784
714 714 a, c dbSNP:771667570
722 722 a, g dbSNP:745418043
727 727 c, t dbSNP:778331869
730 730 a, g dbSNP:756774985
740 740 g, t dbSNP:771720874
757 757 c, t dbSNP:375479974
759 759 g, t dbSNP:78226748
764 764 a, c dbSNP:773984279
774 774 a, g dbSNP:770384688
806 806 c, t dbSNP:267598837
809 809 g, t dbSNP:774783730
812 812 a, c, g dbSNP:747380647
827 827 c, g dbSNP:192715508
830 830 c, g dbSNP:758822761
834 834 a, c, g, t dbSNP:144433180
848 848 c, t dbSNP:753907701
855 855 a, g dbSNP:763972631
862 862 a, g dbSNP:760543225
876 876 a, g dbSNP:751326922
902 902 a, g dbSNP:138009692
913 913 a, g, t dbSNP:772717932
923 923 c, t dbSNP:764879783
926 926 a, c dbSNP:761403727
931 931 c, t dbSNP:776195456
942 942 a, g dbSNP:772647095
963 963 g, t dbSNP:746237682
965 965 a, c, t dbSNP:140343610
968 968 a, g dbSNP:771077544
977 977 c, t dbSNP:749569629
984 984 a, g dbSNP:553523253
987 987 a, g, t dbSNP:146219183
989 989 c, t dbSNP:200794209
1014 1014 a, g dbSNP:781114719
1030 1030 c, t dbSNP:754871430
1037 1037 a, c, t dbSNP:368729538
1038 1038 a, g dbSNP:758098043
1039 1039 g, t dbSNP:539539347
1052 1052 c, t dbSNP:750156794
1053 1053 a, g dbSNP:764969583
1055 1055 c, t dbSNP:761420279
1079 1079 c, t dbSNP:776211846
1081 1081 a, g dbSNP:147880290
1092 1092 c, t dbSNP:760036789
1096 1096 c, t dbSNP:774695305
1100 1100 a, g dbSNP:771362330
1105 1105 c, g dbSNP:367691903
1107 1107 a, g dbSNP:749606925
1112 1112 a, g dbSNP:773501040
1115 1115 g, t dbSNP:769939971
1143 1143 a, g dbSNP:188964071
1168 1168 c, t dbSNP:570717396
1183 1183 a, c dbSNP:10176689
1204 1204 a, t dbSNP:763169464
1279 1279 c, t dbSNP:771537638
1366 1366 c, t dbSNP:537366413
1373 1373 c, t dbSNP:567700928
1377 1377 a, g dbSNP:547808878
1419 1419 -, c dbSNP:755240753
1421 1421 c, t dbSNP:528183322
1498 1498 g, t dbSNP:15610
1542 1542 -, caatt dbSNP:144284916
1556 1556 a, g dbSNP:565675977
1561 1561 c, g dbSNP:142194680
1587 1587 c, g dbSNP:1071676
1597 1597 a, t dbSNP:768605724
1613 1613 c, t dbSNP:533906112
1627 1627 c, t dbSNP:749231749

Target ORF information:

RefSeq Version XM_006712496
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006712496

ORF Insert Sequence:

1
61
121
181
241
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361
421
481
541
ATGGCTACTG ACATTTGCAA CTCCCTCACT CTTTCTCAGG GGCCTTTCAC TTACATTGTC 
ACCAGAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT
GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT
CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC
TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC
AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG
GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC
AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC
AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT
ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25334
Accession Version NM_000576.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-1 beta proprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M15330.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2003 this sequence version replaced gi:10835144. Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008678.1, K02770.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000567.1
CDS88..897
Misc Feature(1)88..396(+)
Misc Feature(2)166..168(+)
Misc Feature(3)166..168(+)
Misc Feature(4)433..435(+)
Misc Feature(5)433..435(+)
Misc Feature(6)445..447(+)
Misc Feature(7)454..882(+)
Misc Feature(8)460..870(+)
Misc Feature(9)475..825(+)
Misc Feature(10)508..510(+)
Exon (1)1..72
Gene:IL1B
Gene Synonym:
Exon (2)73..134
Gene:IL1B
Gene Synonym:
Exon (3)135..186
Gene:IL1B
Gene Synonym:
Exon (4)187..388
Gene:IL1B
Gene Synonym:
Exon (5)389..553
Gene:IL1B
Gene Synonym:
Exon (6)554..684
Gene:IL1B
Gene Synonym:
Exon (7)685..1498
Gene:IL1B
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, c dbSNP:561088583
20 20 a, c dbSNP:1133555
26 26 a, t dbSNP:115403599
39 39 c, g dbSNP:781566483
40 40 g, t dbSNP:1799916
49 49 c, t dbSNP:1133558
75 75 a, g dbSNP:556698777
89 89 c, g, t dbSNP:533327440
97 97 a, g dbSNP:755035830
100 100 a, c dbSNP:370988408
108 108 c, t dbSNP:766271872
109 109 a, g dbSNP:762704392
115 115 a, g dbSNP:376289593
119 119 c, t dbSNP:369312177
122 122 c, t dbSNP:764829099
129 129 c, t dbSNP:761463780
135 135 c, t dbSNP:137872663
137 137 a, g dbSNP:763810887
164 164 c, g dbSNP:760315164
179 179 a, t dbSNP:200223008
185 185 a, c dbSNP:766796135
187 187 c, t dbSNP:569468521
190 190 g, t dbSNP:755758115
193 193 g, t dbSNP:373677368
204 204 a, g dbSNP:767111055
207 207 a, c dbSNP:373127037
211 211 a, t dbSNP:369824057
224 224 a, g dbSNP:758962139
225 225 c, t dbSNP:140794289
226 226 a, g dbSNP:140821206
228 228 a, c, t dbSNP:143589371
232 232 a, c dbSNP:529396429
237 237 a, g dbSNP:760831358
239 239 a, g dbSNP:775562734
246 246 c, t dbSNP:538083388
247 247 a, g dbSNP:568715066
258 258 c, t dbSNP:16062
270 270 c, t dbSNP:770945985
273 273 a, g dbSNP:749096227
275 275 a, g dbSNP:200278471
280 280 a, g dbSNP:755957216
281 281 c, t dbSNP:371093341
282 282 a, g dbSNP:780676196
309 309 a, g dbSNP:754564004
315 315 a, g dbSNP:750985322
321 321 a, g dbSNP:62157449
341 341 g, t dbSNP:376341819
351 351 c, t dbSNP:373172825
352 352 a, g dbSNP:371339015
354 354 c, t dbSNP:531916859
362 362 c, t dbSNP:200401035
366 366 c, t dbSNP:772164980
374 374 -, t dbSNP:774777265
378 378 a, c dbSNP:759687974
390 390 a, g dbSNP:752959492
393 393 g, t dbSNP:767816421
401 401 c, t dbSNP:373103547
402 402 c, t dbSNP:1143634
403 403 a, g dbSNP:139843362
405 405 c, t dbSNP:766629497
408 408 a, g dbSNP:148588074
412 412 a, g dbSNP:773330409
414 414 c, t dbSNP:769804231
417 417 a, c, t dbSNP:141525769
418 418 a, g dbSNP:201772036
421 421 a, g dbSNP:372265184
423 423 a, t dbSNP:779679002
428 428 c, t dbSNP:571556428
429 429 g, t dbSNP:745362909
430 430 c, t dbSNP:778278424
432 432 c, t dbSNP:756541790
435 435 c, t dbSNP:753113614
448 448 c, t dbSNP:767825199
451 451 c, g dbSNP:755362270
455 455 a, g dbSNP:751767196
461 461 c, t dbSNP:766684369
462 462 a, g dbSNP:551821803
466 466 c, t dbSNP:200498551
467 467 a, g dbSNP:765269921
487 487 c, t dbSNP:200789364
488 488 a, t dbSNP:761597173
490 490 a, g dbSNP:776618633
510 510 a, c dbSNP:144640380
519 519 g, t dbSNP:746790289
526 526 c, t dbSNP:775174784
529 529 a, c dbSNP:771667570
537 537 a, g dbSNP:745418043
542 542 c, t dbSNP:778331869
545 545 a, g dbSNP:756774985
555 555 g, t dbSNP:771720874
572 572 c, t dbSNP:375479974
574 574 g, t dbSNP:78226748
579 579 a, c dbSNP:773984279
589 589 a, g dbSNP:770384688
621 621 c, t dbSNP:267598837
624 624 g, t dbSNP:774783730
627 627 a, c, g dbSNP:747380647
642 642 c, g dbSNP:192715508
645 645 c, g dbSNP:758822761
649 649 a, c, g, t dbSNP:144433180
663 663 c, t dbSNP:753907701
670 670 a, g dbSNP:763972631
677 677 a, g dbSNP:760543225
691 691 a, g dbSNP:751326922
717 717 a, g dbSNP:138009692
728 728 a, g, t dbSNP:772717932
738 738 c, t dbSNP:764879783
741 741 a, c dbSNP:761403727
746 746 c, t dbSNP:776195456
757 757 a, g dbSNP:772647095
778 778 g, t dbSNP:746237682
780 780 a, c, t dbSNP:140343610
783 783 a, g dbSNP:771077544
792 792 c, t dbSNP:749569629
799 799 a, g dbSNP:553523253
802 802 a, g, t dbSNP:146219183
804 804 c, t dbSNP:200794209
829 829 a, g dbSNP:781114719
845 845 c, t dbSNP:754871430
852 852 a, c, t dbSNP:368729538
853 853 a, g dbSNP:758098043
854 854 g, t dbSNP:539539347
867 867 c, t dbSNP:750156794
868 868 a, g dbSNP:764969583
870 870 c, t dbSNP:761420279
894 894 c, t dbSNP:776211846
896 896 a, g dbSNP:147880290
907 907 c, t dbSNP:760036789
911 911 c, t dbSNP:774695305
915 915 a, g dbSNP:771362330
920 920 c, g dbSNP:367691903
922 922 a, g dbSNP:749606925
927 927 a, g dbSNP:773501040
930 930 g, t dbSNP:769939971
958 958 a, g dbSNP:188964071
983 983 c, t dbSNP:570717396
998 998 a, c dbSNP:10176689
1019 1019 a, t dbSNP:763169464
1094 1094 c, t dbSNP:771537638
1181 1181 c, t dbSNP:537366413
1188 1188 c, t dbSNP:567700928
1192 1192 a, g dbSNP:547808878
1234 1234 -, c dbSNP:755240753
1236 1236 c, t dbSNP:528183322
1313 1313 g, t dbSNP:15610
1357 1357 -, caatt dbSNP:144284916
1371 1371 a, g dbSNP:565675977
1376 1376 c, g dbSNP:142194680
1402 1402 c, g dbSNP:1071676
1412 1412 a, t dbSNP:768605724
1428 1428 c, t dbSNP:533906112
1442 1442 c, t dbSNP:749231749

Target ORF information:

RefSeq Version NM_000576
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 1, beta (IL1B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000576

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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