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IL2RA interleukin 2 receptor, alpha [Homo sapiens (human)]

Gene Symbol IL2RA
Entrez Gene ID 3559
Full Name interleukin 2 receptor, alpha
Synonyms CD25, IDDM10, IL2R, TCGFR, p55
General protein information
Preferred Names
interleukin-2 receptor subunit alpha
Names
interleukin-2 receptor subunit alpha
p55
IL2-RA
IL-2-RA
TAC antigen
IL-2R subunit alpha
IL-2 receptor subunit alpha
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10p15-p14

Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. lac of sum
Disorder MIM:

147730

Disorder Html: Interleukin-2 receptor, alpha chain, deficiency of, 606367 (3);





The following IL2RA gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RA gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu58389 NM_001308243 Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu21222 NM_000417 Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.3
$309
OHu43745 NM_001308242 Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu58389
Accession Version NM_001308243.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 05-MAY-2015
Organism Homo sapiens (human)
Product interleukin-2 receptor subunit alpha isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD701954.1, CR996090.1, X01057.1 and AL137186.18. Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. Transcript Variant: This variant (3) lacks two in-frame exons in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR986327.1, CR996090.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGATT TTCAAATACA GACAGAAATG GCTGCAACCA TGGAGACGTC CATATTTACA
ACAGAGTACC AGGTAGCAGT GGCCGGCTGT GTTTTCCTGC TGATCAGCGT CCTCCTCCTG
AGTGGGCTCA CCTGGCAGCG GAGACAGAGG AAGAGTAGAA GAACAATCTA G
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001295172.1
CDS220..750
Misc Feature(1)148..150(+)
Exon (1)1..283
Gene:IL2RA
Gene Synonym:
Exon (2)284..475
Gene:IL2RA
Gene Synonym:
Exon (3)476..586
Gene:IL2RA
Gene Synonym:
Exon (4)587..658
Gene:IL2RA
Gene Synonym:
Exon (5)659..725
Gene:IL2RA
Gene Synonym:
Exon (6)726..2928
Gene:IL2RA
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_001308243
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001308243

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGATT TTCAAATACA GACAGAAATG GCTGCAACCA TGGAGACGTC CATATTTACA
ACAGAGTACC AGGTAGCAGT GGCCGGCTGT GTTTTCCTGC TGATCAGCGT CCTCCTCCTG
AGTGGGCTCA CCTGGCAGCG GAGACAGAGG AAGAGTAGAA GAACAATCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21222
Accession Version NM_000417.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 819bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 05-MAY-2015
Organism Homo sapiens (human)
Product interleukin-2 receptor subunit alpha isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL157395.17, X01057.1 and AL137186.18. On Nov 28, 2009 this sequence version replaced gi:4557666. Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X01057.1, AK223313.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGGTC ACTGCAGGGA ACCTCCACCA TGGGAAAATG AAGCCACAGA GAGAATTTAT
CATTTCGTGG TGGGGCAGAT GGTTTATTAT CAGTGCGTCC AGGGATACAG GGCTCTACAC
AGAGGTCCTG CTGAGAGCGT CTGCAAAATG ACCCACGGGA AGACAAGGTG GACCCAGCCC
CAGCTCATAT GCACAGGTGA AATGGAGACC AGTCAGTTTC CAGGTGAAGA GAAGCCTCAG
GCAAGCCCCG AAGGCCGTCC TGAGAGTGAG ACTTCCTGCC TCGTCACAAC AACAGATTTT
CAAATACAGA CAGAAATGGC TGCAACCATG GAGACGTCCA TATTTACAAC AGAGTACCAG
GTAGCAGTGG CCGGCTGTGT TTTCCTGCTG ATCAGCGTCC TCCTCCTGAG TGGGCTCACC
TGGCAGCGGA GACAGAGGAA GAGTAGAAGA ACAATCTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000408.1
CDS220..1038
Misc Feature(1)148..150(+)
Misc Feature(2)289..420(+)
Misc Feature(3)295..453(+)
Misc Feature(4)364..459(+)
Misc Feature(5)370..465(+)
Misc Feature(6)592..771(+)
Misc Feature(7)592..723(+)
Misc Feature(8)619..678(+)
Misc Feature(9)673..771(+)
Misc Feature(10)940..996(+)
Misc Feature(11)1021..1023(+)
Misc Feature(12)1030..1032(+)
Exon (1)1..283
Gene:IL2RA
Gene Synonym:
Exon (2)284..475
Gene:IL2RA
Gene Synonym:
Exon (3)476..586
Gene:IL2RA
Gene Synonym:
Exon (4)587..802
Gene:IL2RA
Gene Synonym:
Exon (5)803..874
Gene:IL2RA
Gene Synonym:
Exon (6)875..946
Gene:IL2RA
Gene Synonym:
Exon (7)947..1013
Gene:IL2RA
Gene Synonym:
Exon (8)1014..3216
Gene:IL2RA
Gene Synonym:
Translation
Position Chain Variation Link
14 14 c, t dbSNP:757996923
43 43 a, g dbSNP:543871712
61 61 a, t dbSNP:766745489
84 84 g, t dbSNP:576484330
87 87 g, t dbSNP:555068563
103 103 c, t dbSNP:561243975
115 115 c, t dbSNP:572610951
127 127 g, t dbSNP:72650659
131 131 c, g dbSNP:74162091
151 151 a, c dbSNP:554029632
152 152 g, t dbSNP:539210850
169 169 c, g dbSNP:763417993
170 170 a, g dbSNP:775868491
174 174 a, g dbSNP:75830636
180 180 c, t dbSNP:760443523
183 183 c, t dbSNP:772713585
188 188 c, t dbSNP:771622922
190 190 c, t dbSNP:747610624
197 197 a, g dbSNP:778855179
199 199 c, t dbSNP:768519633
201 201 g, t dbSNP:144690178
214 214 a, g dbSNP:779962326
220 220 a, g dbSNP:755829547
251 251 c, t dbSNP:750706858
259 259 a, c dbSNP:781222262
264 264 a, g dbSNP:74162092
265 265 c, g dbSNP:751620727
275 275 g, t dbSNP:764712311
283 283 a, g dbSNP:267602536
286 286 c, g dbSNP:751819134
292 292 a, g dbSNP:201995749
294 294 c, t dbSNP:547040700
295 295 a, c, g dbSNP:55868253
303 303 a, g dbSNP:2228150
305 305 c, t dbSNP:148505161
310 310 a, c dbSNP:372125213
317 317 a, t dbSNP:761518137
319 319 a, g dbSNP:773957702
323 323 c, t dbSNP:763638163
336 336 a, g dbSNP:146345652
344 344 a, g dbSNP:142016545
359 359 c, t dbSNP:769549397
361 361 a, g dbSNP:745686694
370 370 c, t dbSNP:755535751
387 387 c, t dbSNP:776627670
399 399 c, t dbSNP:74162093
400 400 a, g dbSNP:201617475
402 402 c, g dbSNP:760943292
411 411 c, t dbSNP:778122850
412 412 a, g dbSNP:372359952
420 420 c, t dbSNP:758530738
423 423 a, g dbSNP:563759672
424 424 a, g dbSNP:779481535
429 429 c, t dbSNP:755493932
431 431 c, g, t dbSNP:766766658
440 440 c, t dbSNP:756444069
441 441 a, g dbSNP:751234465
444 444 c, t dbSNP:372481445
455 455 a, g dbSNP:763695218
459 459 c, t dbSNP:41306826
461 461 a, g dbSNP:762527969
465 465 c, t dbSNP:774803573
482 482 a, c, g dbSNP:139340259
490 490 a, g dbSNP:753853235
491 491 -, t dbSNP:36065822
491 491 c, t dbSNP:72650666
492 492 a, g dbSNP:41290331
498 498 a, g dbSNP:773086693
499 499 a, g dbSNP:771893707
500 500 a, t dbSNP:761978980
501 501 a, g dbSNP:774606930
516 516 a, t dbSNP:201105599
519 519 a, g dbSNP:200838485
524 524 a, g dbSNP:749326313
527 527 a, t dbSNP:780542426
531 531 a, g dbSNP:770226758
551 551 a, g dbSNP:56054476
556 556 a, g dbSNP:781478336
557 557 g, t dbSNP:76029930
561 561 a, g dbSNP:376596128
566 566 c, t dbSNP:74162095
567 567 a, g dbSNP:752342176
575 575 c, t dbSNP:138645280
576 576 a, g dbSNP:150164762
583 583 c, g dbSNP:753336611
601 601 a, c dbSNP:747351412
603 603 c, t dbSNP:773687056
604 604 a, c dbSNP:772563186
610 610 c, g, t dbSNP:779802160
612 612 g, t dbSNP:755713136
623 623 c, g dbSNP:745306282
629 629 a, g dbSNP:781005101
630 630 a, g dbSNP:546465474
636 636 g, t dbSNP:751445826
640 640 c, t dbSNP:267602533
644 644 -, t dbSNP:766504939
645 645 c, t dbSNP:763915787
647 647 c, t dbSNP:763312995
655 655 a, c dbSNP:141655051
658 658 a, t dbSNP:147975326
660 660 g, t dbSNP:575199237
672 672 a, g, t dbSNP:765403608
675 675 c, t dbSNP:377104035
676 676 a, g dbSNP:201188114
678 678 c, g dbSNP:766358118
687 687 c, t dbSNP:761314426
689 689 a, g dbSNP:562347103
697 697 c, t dbSNP:773829518
698 698 a, g dbSNP:772585400
699 699 a, c, t dbSNP:775282989
703 703 a, g dbSNP:146966522
704 704 a, g dbSNP:141246728
706 706 c, t dbSNP:780819738
714 714 c, g, t dbSNP:776347887
717 717 c, t dbSNP:747017654
718 718 a, g dbSNP:147791171
733 733 c, t dbSNP:372508950
735 735 c, t dbSNP:2228149
736 736 a, g dbSNP:752423140
746 746 a, g dbSNP:55841382
766 766 a, g dbSNP:746647595
767 767 c, t dbSNP:754005049
776 776 a, c, g dbSNP:368304698
777 777 c, t dbSNP:750997079
778 778 a, g dbSNP:768065888
781 781 a, g dbSNP:149181289
791 791 c, g dbSNP:774912787
793 793 c, g dbSNP:768898568
798 798 a, t dbSNP:376008631
804 804 c, t dbSNP:570897174
814 814 a, c dbSNP:752079992
818 818 a, c dbSNP:764567613
825 825 c, t dbSNP:763179568
828 828 a, c, t dbSNP:760357500
829 829 a, g dbSNP:370516220
832 832 a, g dbSNP:772770506
833 833 a, g dbSNP:771569456
836 836 a, g, t dbSNP:774136663
841 841 a, g dbSNP:768524031
843 843 c, g dbSNP:367926771
847 847 a, g dbSNP:780335134
861 861 c, t dbSNP:756459089
862 862 a, g dbSNP:145428184
867 867 a, g dbSNP:781460451
868 868 a, g dbSNP:757389911
870 870 a, g dbSNP:373337461
871 871 -, aca dbSNP:769164022
878 878 c, t dbSNP:572336497
884 884 c, t dbSNP:750102384
887 887 -, a dbSNP:746007785
888 888 a, g dbSNP:539966138
902 902 c, t dbSNP:767085799
910 910 c, g dbSNP:150060415
912 912 a, g dbSNP:139266750
914 914 c, t dbSNP:763651926
915 915 a, g dbSNP:762837534
916 916 c, t dbSNP:201522266
919 919 a, g dbSNP:375756091
921 921 a, c dbSNP:769176990
928 928 a, g dbSNP:769734470
930 930 a, g dbSNP:11256354
934 934 c, t dbSNP:776999325
936 936 a, c dbSNP:138764230
940 940 c, g dbSNP:773200576
948 948 a, g dbSNP:74162100
949 949 a, g dbSNP:748222977
951 951 c, t dbSNP:779403244
952 952 a, g dbSNP:769206097
964 964 c, t dbSNP:749789593
970 970 a, g dbSNP:780433925
972 972 c, t dbSNP:12722698
974 974 c, g dbSNP:751192304
975 975 a, c, t dbSNP:113428577
976 976 a, g dbSNP:143550766
978 978 a, c dbSNP:752198531
979 979 c, t dbSNP:764826745
987 987 a, g dbSNP:755034813
992 992 a, g dbSNP:753797918
996 996 a, c dbSNP:554680869
1006 1006 c, t dbSNP:140088691
1007 1007 a, g dbSNP:536344946
1014 1014 a, g dbSNP:767207934
1019 1019 -, aga dbSNP:757598971
1023 1023 c, t dbSNP:762059830
1025 1025 a, g dbSNP:774531130
1031 1031 a, c, g dbSNP:762979594
1032 1032 a, g dbSNP:775980513
1034 1034 c, t dbSNP:12722712
1042 1042 -, a dbSNP:752490211
1051 1051 a, g dbSNP:746347754
1067 1067 a, c, g dbSNP:769795224
1074 1074 c, t dbSNP:372312640
1075 1075 a, g dbSNP:747854116
1084 1084 a, c dbSNP:778662335
1088 1088 a, c dbSNP:575663406
1093 1093 c, t dbSNP:12722713
1099 1099 a, g dbSNP:547047548
1108 1108 a, g dbSNP:12722600
1137 1137 a, g dbSNP:753838977
1142 1142 a, g dbSNP:749452297
1145 1145 c, t dbSNP:12722714
1161 1161 a, g dbSNP:549892288
1187 1187 c, g dbSNP:531582979
1204 1204 a, g dbSNP:560898947
1221 1221 a, c dbSNP:542942584
1240 1240 a, g dbSNP:572213760
1243 1243 c, t dbSNP:367718232
1247 1247 c, t dbSNP:535911457
1277 1277 a, g dbSNP:559720581
1312 1312 a, g dbSNP:185829590
1343 1343 c, g dbSNP:756213567
1352 1352 a, g dbSNP:751588150
1361 1361 g, t dbSNP:12722715
1420 1420 -, c dbSNP:34686279
1433 1433 g, t dbSNP:574873827
1482 1482 a, t dbSNP:12722601
1491 1491 c, t dbSNP:768574986
1499 1499 c, g dbSNP:181357994
1509 1509 a, g dbSNP:553112485
1516 1516 c, g dbSNP:188613092
1526 1526 a, c, t dbSNP:576607759
1554 1554 c, t dbSNP:554828895
1620 1620 a, c dbSNP:56206280
1637 1637 c, g dbSNP:541601070
1643 1643 c, t dbSNP:536972453
1647 1647 a, g dbSNP:764877940
1714 1714 a, c dbSNP:566194606
1715 1715 a, g dbSNP:12719919
1744 1744 g, t dbSNP:76471890
1745 1745 c, g dbSNP:75779793
1747 1747 a, c dbSNP:76242406
1790 1790 a, g dbSNP:41290329
1805 1805 c, t dbSNP:143416542
1824 1824 c, t dbSNP:549930913
1876 1876 a, c dbSNP:531419003
1923 1923 a, g dbSNP:760142892
1926 1926 c, t dbSNP:12722716
1927 1927 a, g dbSNP:147669116
1967 1967 c, t dbSNP:775924333
1991 1991 c, t dbSNP:12722717
2001 2001 a, c dbSNP:527589024
2004 2004 a, g dbSNP:759899126
2007 2007 a, g dbSNP:12722602
2024 2024 a, c dbSNP:544896196
2046 2046 a, g dbSNP:34164172
2062 2062 a, g dbSNP:12722718
2064 2064 a, g, t dbSNP:28360484
2079 2079 c, t dbSNP:141524746
2080 2080 a, g dbSNP:542812308
2082 2082 c, t dbSNP:572589682
2085 2085 c, t dbSNP:781076912
2099 2099 c, t dbSNP:55885853
2107 2107 c, t dbSNP:149796519
2113 2113 a, c dbSNP:571299400
2123 2123 a, g dbSNP:374118462
2138 2138 g, t dbSNP:537968636
2158 2158 c, t dbSNP:745755601
2196 2196 -, aatta dbSNP:543983290
2214 2214 a, g dbSNP:567205124
2224 2224 c, t dbSNP:12722603
2272 2272 c, t dbSNP:370765858
2288 2288 g, t dbSNP:527536271
2299 2299 a, t dbSNP:115247277
2305 2305 a, g dbSNP:1570538
2315 2315 a, g dbSNP:533020456
2353 2353 a, g dbSNP:529774081
2362 2362 g, t dbSNP:151183621
2370 2370 a, g dbSNP:763727948
2381 2381 a, c dbSNP:12722719
2411 2411 a, c dbSNP:755674960
2416 2416 a, g dbSNP:555259758
2427 2427 -, g dbSNP:774337279
2466 2466 a, g dbSNP:143496123
2497 2497 a, c dbSNP:752262905
2499 2499 c, t dbSNP:12244380
2566 2566 a, g dbSNP:760118576
2572 2572 -, tg dbSNP:71390108
2575 2575 -, gt dbSNP:148885460
2587 2587 c, t dbSNP:12722604
2627 2627 c, t dbSNP:766898254
2637 2637 a, g dbSNP:763406166
2657 2657 a, g dbSNP:773626989
2678 2678 c, t dbSNP:770156563
2687 2687 c, t dbSNP:184686521
2710 2710 a, t dbSNP:12722605
2740 2740 c, t dbSNP:12722606
2810 2810 a, c dbSNP:74973937
2815 2815 a, g dbSNP:542143897
2842 2842 g, t dbSNP:556200257
2854 2854 a, g dbSNP:537404393
2865 2865 g, t dbSNP:546491159
2918 2918 c, g dbSNP:12722607
3012 3012 c, t dbSNP:12722720
3013 3013 a, g dbSNP:555221196
3032 3032 g, t dbSNP:12722608
3040 3040 c, g dbSNP:192145132
3071 3071 a, g dbSNP:761805503
3076 3076 c, t dbSNP:551131164
3077 3077 a, g dbSNP:539350013
3089 3089 a, g dbSNP:573034970
3093 3093 c, t dbSNP:561032746
3103 3103 a, g dbSNP:550450134
3138 3138 c, t dbSNP:531654198
3146 3146 g, t dbSNP:74895246
3169 3169 a, g dbSNP:549245031
3182 3182 g, t dbSNP:757107768

Target ORF information:

RefSeq Version NM_000417
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000417

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGGTC ACTGCAGGGA ACCTCCACCA TGGGAAAATG AAGCCACAGA GAGAATTTAT
CATTTCGTGG TGGGGCAGAT GGTTTATTAT CAGTGCGTCC AGGGATACAG GGCTCTACAC
AGAGGTCCTG CTGAGAGCGT CTGCAAAATG ACCCACGGGA AGACAAGGTG GACCCAGCCC
CAGCTCATAT GCACAGGTGA AATGGAGACC AGTCAGTTTC CAGGTGAAGA GAAGCCTCAG
GCAAGCCCCG AAGGCCGTCC TGAGAGTGAG ACTTCCTGCC TCGTCACAAC AACAGATTTT
CAAATACAGA CAGAAATGGC TGCAACCATG GAGACGTCCA TATTTACAAC AGAGTACCAG
GTAGCAGTGG CCGGCTGTGT TTTCCTGCTG ATCAGCGTCC TCCTCCTGAG TGGGCTCACC
TGGCAGCGGA GACAGAGGAA GAGTAGAAGA ACAATCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu43745
Accession Version NM_001308242.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 603bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-MAY-2015
Organism Homo sapiens (human)
Product interleukin-2 receptor subunit alpha isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD701954.1, K03122.1, X01057.1 and AL137186.18. On Apr 28, 2015 this sequence version replaced gi:530392147. Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K03122.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGGTG AAGAGAAGCC TCAGGCAAGC CCCGAAGGCC GTCCTGAGAG TGAGACTTCC
TGCCTCGTCA CAACAACAGA TTTTCAAATA CAGACAGAAA TGGCTGCAAC CATGGAGACG
TCCATATTTA CAACAGAGTA CCAGGTAGCA GTGGCCGGCT GTGTTTTCCT GCTGATCAGC
GTCCTCCTCC TGAGTGGGCT CACCTGGCAG CGGAGACAGA GGAAGAGTAG AAGAACAATC
TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001295171.1
CDS220..822
Misc Feature(1)148..150(+)
Misc Feature(2)295..453(+)
Exon (1)1..283
Gene:IL2RA
Gene Synonym:
Exon (2)284..475
Gene:IL2RA
Gene Synonym:
Exon (3)476..586
Gene:IL2RA
Gene Synonym:
Exon (4)587..658
Gene:IL2RA
Gene Synonym:
Exon (5)659..730
Gene:IL2RA
Gene Synonym:
Exon (6)731..797
Gene:IL2RA
Gene Synonym:
Exon (7)798..3000
Gene:IL2RA
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_001308242
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001308242

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGATTCAT ACCTGCTGAT GTGGGGACTG CTCACGTTCA TCATGGTGCC TGGCTGCCAG 
GCAGAGCTCT GTGACGATGA CCCGCCAGAG ATCCCACACG CCACATTCAA AGCCATGGCC
TACAAGGAAG GAACCATGTT GAACTGTGAA TGCAAGAGAG GTTTCCGCAG AATAAAAAGC
GGGTCACTCT ATATGCTCTG TACAGGAAAC TCTAGCCACT CGTCCTGGGA CAACCAATGT
CAATGCACAA GCTCTGCCAC TCGGAACACA ACGAAACAAG TGACACCTCA ACCTGAAGAA
CAGAAAGAAA GGAAAACCAC AGAAATGCAA AGTCCAATGC AGCCAGTGGA CCAAGCGAGC
CTTCCAGGTG AAGAGAAGCC TCAGGCAAGC CCCGAAGGCC GTCCTGAGAG TGAGACTTCC
TGCCTCGTCA CAACAACAGA TTTTCAAATA CAGACAGAAA TGGCTGCAAC CATGGAGACG
TCCATATTTA CAACAGAGTA CCAGGTAGCA GTGGCCGGCT GTGTTTTCCT GCTGATCAGC
GTCCTCCTCC TGAGTGGGCT CACCTGGCAG CGGAGACAGA GGAAGAGTAG AAGAACAATC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.