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CXCL8 chemokine (C-X-C motif) ligand 8 [Homo sapiens (human)]

Gene Symbol CXCL8
Entrez Gene ID 3576
Full Name chemokine (C-X-C motif) ligand 8
Synonyms GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1
General protein information
Preferred Names
interleukin-8
Names
interleukin-8
emoctakin
T-cell chemotactic factor
neutrophil-activating peptide 1
chemokine (C-X-C motif) ligand 8
beta-thromboglobulin-like protein
granulocyte chemotactic protein 1
tumor necrosis factor-induced gene 1
alveolar macrophage chemotactic factor I
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
small inducible cytokine subfamily B, member 8
lymphocyte derived neutrophil activating peptide
lung giant cell carcinoma-derived chemotactic protein
beta endothelial cell-derived neutrophil activating peptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q13-q21

Summary The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

146930

Disorder Html:





The following CXCL8 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL8 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20145 NM_000584 Homo sapiens chemokine (C-X-C motif) ligand 8 (CXCL8), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu20145
Accession Version NM_000584.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-8 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG497712.1 and BC013615.1. This sequence is a reference standard in the RefSeqGene project. On Feb 25, 2011 this sequence version replaced gi:28610153. Summary: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M26383.1, AK131067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGACTTCCA AGCTGGCCGT GGCTCTCTTG GCAGCCTTCC TGATTTCTGC AGCTCTGTGT 
GAAGGTGCAG TTTTGCCAAG GAGTGCTAAA GAACTTAGAT GTCAGTGCAT AAAGACATAC
TCCAAACCTT TCCACCCCAA ATTTATCAAA GAACTGAGAG TGATTGAGAG TGGACCACAC
TGCGCCAACA CAGAAATTAT TGTAAAGCTT TCTGATGGAA GAGAGCTCTG TCTGGACCCC
AAGGAAAACT GGGTGCAGAG GGTTGTGGAG AAGTTTTTGA AGAGGGCTGA GAATTCATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000575.1
CDS154..453
Misc Feature(1)58..60(+)
Misc Feature(2)232..237(+)
Misc Feature(3)232..234(+)
Misc Feature(4)232..234(+)
Misc Feature(5)235..240(+)
Misc Feature(6)235..237(+)
Misc Feature(7)244..435(+)
Misc Feature(8)244..414(+)
Misc Feature(9)244..252(+)
Misc Feature(10)247..432(+)
Misc Feature(11)247..378(+)
Misc Feature(12)250..261(+)
Misc Feature(13)256..300(+)
Misc Feature(14)262..381(+)
Misc Feature(15)286..435(+)
Misc Feature(16)292..378(+)
Misc Feature(17)298..432(+)
Misc Feature(18)325..333(+)
Misc Feature(19)325..333(+)
Misc Feature(20)364..372(+)
Exon (1)1..217
Gene:CXCL8
Gene Synonym:
Exon (2)218..353
Gene:CXCL8
Gene Synonym:
Exon (3)354..437
Gene:CXCL8
Gene Synonym:
Exon (4)438..1705
Gene:CXCL8
Gene Synonym:
Translation
Position Chain Variation Link
5 5 a, g dbSNP:201529644
9 9 a, c dbSNP:200170390
26 26 c, g dbSNP:200985494
31 31 c, g dbSNP:745972404
46 46 c, t dbSNP:201952119
47 47 a, g dbSNP:200094083
56 56 c, t dbSNP:556828071
103 103 a, g dbSNP:753062658
110 110 c, t dbSNP:757928567
118 118 a, g dbSNP:777538708
125 125 c, t dbSNP:201217708
126 126 a, g dbSNP:2227537
133 133 a, g, t dbSNP:56002960
135 135 c, t dbSNP:769861207
137 137 -, t dbSNP:757213702
141 141 a, g dbSNP:779939265
148 148 g, t dbSNP:749155774
152 152 a, c dbSNP:200141723
153 153 c, t dbSNP:2227538
154 154 a, g dbSNP:572157399
162 162 c, t dbSNP:760653250
164 164 a, c dbSNP:202071309
167 167 a, t dbSNP:563959935
169 169 g, t dbSNP:200602609
171 171 c, g, t dbSNP:1803205
176 176 a, c dbSNP:202202182
178 178 c, t dbSNP:564043731
180 180 a, c dbSNP:753044518
183 183 a, g dbSNP:763440988
194 194 a, t dbSNP:200254616
216 216 a, c dbSNP:763622469
217 217 a, g dbSNP:751273843
226 226 c, t dbSNP:150567416
228 228 a, g dbSNP:201644683
229 229 a, c dbSNP:767339386
235 235 a, c dbSNP:199855020
241 241 a, t dbSNP:755727808
243 243 a, g dbSNP:766401225
244 244 a, g, t dbSNP:188378669
245 245 a, c dbSNP:138567132
256 256 a, c, g dbSNP:149273289
270 270 a, g dbSNP:372900552
271 271 c, t dbSNP:745916337
273 273 c, t dbSNP:769909977
274 274 a, t dbSNP:144469788
275 275 a, c dbSNP:749738011
276 276 -, aa dbSNP:779962012
281 281 a, c dbSNP:200107073
287 287 a, g dbSNP:139503118
288 288 c, t dbSNP:202194050
301 301 a, g dbSNP:774766411
303 303 a, g dbSNP:200090643
312 312 a, g dbSNP:145018121
315 315 a, g dbSNP:369065964
317 317 a, c, t dbSNP:202114642
328 328 c, t dbSNP:373821605
329 329 c, t dbSNP:765951700
336 336 a, c, t dbSNP:147544998
337 337 a, g, t dbSNP:140214046
343 343 a, c dbSNP:758228010
344 344 c, g dbSNP:142957504
360 360 a, c, g, t dbSNP:759032011
362 362 c, t dbSNP:762899923
369 369 c, t dbSNP:371104442
375 375 a, g dbSNP:199638674
377 377 -, ct dbSNP:768729285
378 378 c, g dbSNP:751369405
384 384 a, t dbSNP:536774132
388 388 -, a dbSNP:780925576
402 402 a, c dbSNP:373408845
404 404 -, g dbSNP:747764679
405 405 a, g dbSNP:780209935
413 413 a, g dbSNP:753921688
414 414 a, c, g dbSNP:756294837
416 416 a, c, t dbSNP:779068762
420 420 a, g dbSNP:370518457
431 431 a, t dbSNP:200662278
434 434 a, g dbSNP:185040023
435 435 a, g dbSNP:772706294
438 438 a, g dbSNP:778788011
440 440 c, t dbSNP:200005090
441 441 c, t dbSNP:758964660
447 447 c, t dbSNP:200831742
451 451 -, a dbSNP:201169323
452 452 a, t dbSNP:201643630
459 459 a, t dbSNP:778494518
461 461 c, t dbSNP:747349727
465 465 c, t dbSNP:757613710
468 468 c, t dbSNP:111499831
469 469 g, t dbSNP:745472151
472 472 g, t dbSNP:769492733
495 495 c, g dbSNP:202131481
496 496 -, a dbSNP:772969245
499 499 c, t dbSNP:774968097
515 515 c, t dbSNP:201064770
528 528 c, t dbSNP:181891593
533 533 a, g dbSNP:202212802
541 541 a, t dbSNP:200157654
569 569 a, g dbSNP:570175045
571 571 a, g dbSNP:537113120
591 591 a, t dbSNP:200772595
602 602 a, g dbSNP:186487125
624 624 c, g dbSNP:201795267
663 663 g, t dbSNP:200332241
669 669 a, t dbSNP:566873633
683 683 a, g dbSNP:191013479
684 684 a, g dbSNP:111708033
685 685 a, t dbSNP:12420
688 688 a, t dbSNP:201232993
696 696 a, g dbSNP:16849942
702 702 a, g dbSNP:3181685
708 708 a, g dbSNP:202111883
711 711 g, t dbSNP:200298685
717 717 c, t dbSNP:201402794
730 730 c, t dbSNP:199733277
731 731 g, t dbSNP:115993429
752 752 a, c dbSNP:201293456
757 757 a, c dbSNP:199653977
760 760 c, g dbSNP:569988644
766 766 a, g dbSNP:200660960
768 768 c, t dbSNP:202005234
771 771 c, g dbSNP:11733933
780 780 c, t dbSNP:181377418
784 784 c, g dbSNP:201465564
792 792 g, t dbSNP:544877836
798 798 a, g dbSNP:200087373
870 870 a, g dbSNP:201019582
884 884 g, t dbSNP:201581203
895 895 a, g dbSNP:2227544
937 937 g, t dbSNP:201056346
967 967 g, t dbSNP:202210907
969 969 a, g dbSNP:200553398
988 988 a, g dbSNP:201094311
992 992 -, a dbSNP:35607711
999 999 a, c dbSNP:2227545
1003 1003 a, g dbSNP:71532822
1016 1016 c, t dbSNP:562046158
1026 1026 c, t dbSNP:200386331
1047 1047 c, g, t dbSNP:201400317
1062 1062 a, c dbSNP:199798685
1105 1105 -, tta dbSNP:373408246
1105 1105 c, t dbSNP:200292642
1114 1114 a, g dbSNP:201432677
1134 1134 a, c dbSNP:199716768
1160 1160 c, t dbSNP:574225906
1183 1183 g, t dbSNP:541422171
1194 1194 a, c dbSNP:559811934
1195 1195 c, t dbSNP:2227550
1218 1218 g, t dbSNP:201379863
1241 1241 c, t dbSNP:34915905
1259 1259 a, g dbSNP:2227546
1265 1265 c, t dbSNP:201526399
1274 1274 a, c, g dbSNP:71534297
1281 1281 a, t dbSNP:200726942
1290 1290 a, t dbSNP:201695611
1294 1294 c, t dbSNP:200116851
1317 1317 a, t dbSNP:1126647
1336 1336 c, g dbSNP:202137237
1353 1353 a, t dbSNP:199842999
1371 1371 c, t dbSNP:200968841
1376 1376 c, t dbSNP:202126985
1379 1379 c, t dbSNP:200549660
1395 1395 c, t dbSNP:201486099
1407 1407 a, t dbSNP:202034714
1419 1419 a, g dbSNP:200380296
1423 1423 g, t dbSNP:201155499
1424 1424 a, g dbSNP:199840031
1428 1428 g, t dbSNP:11545234
1485 1485 c, g, t dbSNP:200462525
1495 1495 a, t dbSNP:201137776
1530 1530 a, g dbSNP:199713665
1555 1555 c, t dbSNP:200908958
1564 1564 a, c dbSNP:183164466
1583 1583 a, g dbSNP:187944565
1619 1619 c, t dbSNP:201880994
1626 1626 a, t dbSNP:199812157
1671 1671 c, t dbSNP:2227548

Target ORF information:

RefSeq Version NM_000584
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 8 (CXCL8), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000584

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCCA AGCTGGCCGT GGCTCTCTTG GCAGCCTTCC TGATTTCTGC AGCTCTGTGT 
GAAGGTGCAG TTTTGCCAAG GAGTGCTAAA GAACTTAGAT GTCAGTGCAT AAAGACATAC
TCCAAACCTT TCCACCCCAA ATTTATCAAA GAACTGAGAG TGATTGAGAG TGGACCACAC
TGCGCCAACA CAGAAATTAT TGTAAAGCTT TCTGATGGAA GAGAGCTCTG TCTGGACCCC
AAGGAAAACT GGGTGCAGAG GGTTGTGGAG AAGTTTTTGA AGAGGGCTGA GAATTCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.